"Anti-HIV Agents That Selectively Target Retroviral Nucleocapsid Protein Zinc Fingers without Affecting Cellular Zinc Finger ... 2-Diamine That Chelates Zinc Ions from Retroviral Nucleocapsid Zinc Fingers". Antimicrobial Agents and Chemotherapy. 54 (4): ... Musah, Rabi Ann (2004). "The HIV-1 Nucleocapsid Zinc Finger Protein as a Target of Antiretroviral Therapy" (PDF). Current ... "Biophysical Characterization of Zinc Ejection from HIV Nucleocapsid Protein by Anti-HIV 2,2'-Dithiobis[benzamides] and ...

It is now standard of care in the United States to begin anti-retroviral treatment upon discovery of HIV positive status. HIV ... Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. May 4, 2006. (available for download ... Due to the nature of the virus the drugs used to treat HIV are called antiretroviral medicines, and the course of treatment is ... Complete List of Donor Screening Assays for Infectious Agents and HIV Diagnostic Assays. US Food & Drug Administration. ...

... is indicated in combination with other antiretroviral agents for the treatment of HIV-1-infected patients. Though ... WO 1994014436, Kempf DJ, Norbeck DW, Sham HL, Zhao C, Sowin TJ, Reno DS, Haight AR, Cooper AJ, "Retroviral protease inhibiting ... When administered at the initially tested higher doses effective for anti-HIV therapy, the side effects of ritonavir are those ... Ritonavir, sold under the brand name Norvir, is an antiretroviral medication used along with other medications to treat HIV/ ...

As a result, lamivudine was identified as a less toxic agent to mitochondria DNA than other retroviral drugs. Lamivudine was ... Lamivudine (Epivir) is indicated in combination with other antiretroviral agents for the treatment of HIV‑1 infection. ... A better explanation of the data is that lamivudine continues to have a partial anti-viral effect even in the presence of the ... Lamivudine, commonly called 3TC, is an antiretroviral medication used to prevent and treat HIV/AIDS. It is also used to treat ...

Has Favorable Anti-Human Immunodeficiency Virus Interactions with Other Antiretrovirals In Vitro". Antimicrobial Agents and ... In the pivotal trial of leronlimab in combination with standard anti-retroviral therapies in HIV-infected treatment-experienced ... "Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 1: discovery and initial structure-activity relationships for ... "Neutralizing antibody and anti-retroviral drug sensitivities of HIV-1 isolates resistant to small molecule CCR5 inhibitors". ...

HIV in proviral latency is nearly impossible to target with antiretroviral drugs. Several classes of latency reversing agents ( ... In a notable event, this actually happened during gene therapy through the use of retroviral vectors at the Necker Hospital in ... This latent reservoir of HIV may explain the inability of antiretroviral treatment to cure HIV infection. Viruses portal Slow ... November 1997). "Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy". Science. 278 ( ...

... immunologic function can be restored by treatment with highly active anti-retroviral therapy. In kidney transplant recipients ... Other agents that have been proposed to target polyomavirus BK, such as cidofovir, fluoroquinolones, leflunomide, and statins ... Also, some of these agents may cause severe long-lasting side effects.[citation needed] Huang, Gang; Chen, Li-Zhong; Qiu, Jiang ... Antimicrobial Agents and Chemotherapy. 41 (3): 587-93. doi:10.1128/AAC.41.3.587. PMC 163756. PMID 9055998. Gabardi, S.; Waikar ...

He championed for combination anti-retroviral therapy instead of single therapy, which turned HIV from absolute terminal ... The most promising neutralizing agent is a bispecific monoclonal antibody that entered a first-in-human clinical trial in 2019 ... His group was the first to demonstrate protective efficacy of a long-acting antiretroviral drug as pre-exposure prophylaxis in ... Before 1996, AZT and other early 1990s antiretroviral medication were prescribed in single therapy, which still did not prevent ...

... who spread misinformation about HIV tests and even alleged of anti-retroviral therapy to be the causative agent of AIDS; the ... Some of Null's productions portrayed those patients as the real heroes, who rejected anti-retroviral therapy in favor of his ... Discussing Null's anti-vaccination efforts, Harriet Hall deems Null to have a bad track record for scientific credibility. ... Null holds strong anti-vaccination views and rejects the scientific consensus on topics such as water fluoridation, genetically ...

... but it can help slow HIV disease progression in people not taking anti-retroviral therapy (ART). This finding emphasizes the ... Aciclovir trials show that this agent has no role in preventing HIV transmission, ... they risk causing resistance to antiviral agents, and (in 1% to 10% of cases) can cause unpleasant side effects. Aciclovir ...

They are highly effective against HIV and have, since the 1990s, been a key component of anti-retroviral therapies for HIV/AIDS ... In 1985, HIV was identified as the causative agent of acquired immune deficiency syndrome (AIDS) and its complete genome was ... Antiretroviral drug Reverse transcriptase inhibitor Integrase inhibitor Entry inhibitor Discovery and development of non- ... De Clercq, E. (2009) Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV. International Journal of ...

6,319,711 Levo-monosaccharide in a nucleoside analog for use as an anti-retroviral agent, US Patent #6,090,602 Method and ...

... and promising prophylactic in vivo antiretroviral activity in Hu-PBL-SCID mice as well as therapeutic anti-retroviral activity ... Unlike available antiretroviral agents that disrupt a specific step in the life cycle of HIV, stampidine has the potential to ... Uckun FM, Cahn P, Qazi S, D'Cruz O (April 2012). "Stampidine as a promising antiretroviral drug candidate for pre-exposure ... Stampidine is an experimental nucleoside reverse transcriptase inhibitor (NRTI) with anti-HIV activity. It is a derivative of ...

Alternative agents can be used instead of the preferred agents. These alternative agents may be used due to allergies, ... Kong C, Neoh HM, Nathan S (March 2016). "Targeting Staphylococcus aureus Toxins: A Potential form of Anti-Virulence Therapy". ... Opportunistic infections caused by feline leukemia virus and feline immunodeficiency virus retroviral infections can be treated ... The alternative agents are listed in the table below. Treatment depends on the type of opportunistic infection, but usually ...

HIV Antiretroviral Agents in Development IntegraseBookFull Archived 2009-09-24 at the Wayback Machine (PDF) integrase+ ... Since integration is a vital step in retroviral replication, blocking it can halt further spread of the virus. Integrase ... USA (2014). "Antiretroviral Therapy: Current Drugs". Infectious Disease Clinics of North America. Ncbi.nlm.nih.gov. 28 (3): 371 ... Integrase inhibitors (INIs) are a class of antiretroviral drug designed to block the action of integrase, a viral enzyme that ...

... antimitotic agent - antineoplastic - antineoplastic antibiotic - antioxidant - antiparasitic - antiretroviral therapy - ... retroviral vector - retrovirus - RevM10 gene - rhabdoid tumor - rhabdomyosarcoma - rhizoxin - ribavirin - ribonucleotide ... anti-CEA antibody - anti-idiotype vaccine - anti-inflammatory - antiandrogen - antiandrogen therapy - anti-angiogenesis - ... alkylating agent - ALL - all-trans retinoic acid - allogeneic - allogeneic bone marrow transplantation - allogeneic stem cell ...

This compound had been prepared in 1964 as a potential anti-cancer agent but was shown to be ineffective. In 1974 zidovudine ... "Retroviral reverse transcriptases (other than those of HIV-1 and murine leukemia virus): A comparison of their molecular and ... Six NRTI agents and one NtRTI have followed. The NRTIs and the NtRTI are analogues of endogenous 2´-deoxy-nucleoside and ... The 3' carbon of the ribose ring of 2'-deoxycytidine has been replaced by a sulfur atom because it had greater anti-HIV ...

He argued that it is an "illusion to think that monotherapy with any antiretroviral agent will have a major and lasting impact ... He found that a baby's chance of contracting HIV falls to less than 1% if they receive anti-retroviral drugs while being nursed ... Lange, Joep (1995). "Combination Antiretroviral Therapy". Drugs. 49 (Supplement 1): 32-37. doi:10.2165/00003495-199500491-00008 ...

Pope, Michael Thor; Müller, Achim (1994). Polyoxometalates: From Platonic Solids to Anti-Retroviral Activity. Springer. ISBN ... "Transition-metal-substituted polyoxometalate derivatives as functional anti-amyloid agents for Alzheimer's disease". Nature ... Pope, Michael; Müller, Achim (1994). Polyoxometalates: From Platonic Solids to Anti-Retroviral Activity - Springer. Topics in ...

In AIDS patients, perhaps the most important factor with respect to treatment is the use of highly active anti-retroviral ... The most studied chemotherapeutic agent in PCNSL is methotrexate (a folate analogue that interferes with DNA repair). ... Of course, highly active antiretroviral therapy (HAART) is critical for prolonged survival in any AIDS patient, so compliance ... probably due to poor penetration of the agents through the blood brain barrier. Newer treatments, such as high dose ...

"Capravirine - Anti-Retroviral Drug". Drug Development Technology. Retrieved 2019-06-02. "Capravirine - Anti-Retroviral Drug". ... Antiinfective agent stubs). ... Inhibitors in HIV-Infected Patients Who Failed Previous Anti- ...

Scientists are testing whether anti-retroviral lubricants or gels can be applied to aid in the prevention of transmission of ... Additionally, a commonly used numbing agent benzocaine can cause an allergic reaction in those with an allergy to PABA (4- ... 2012). "Is Wetter Better? An Evaluation of Over-the-Counter Personal Lubricants for Safety and Anti-HIV-1 Activity". PLOS ONE. ... Some anal lubricants contain numbing agents to relieve discomfort during anal sex, although it is generally inadvisable as a ...

The many dissemination mechanisms available to HIV contribute to the virus' ongoing replication in spite of anti-retroviral ... A survival strategy for any infectious agent is not to kill its host, but ultimately become a commensal organism. Having ... Viral recombination produces genetic variation that likely contributes to the evolution of resistance to anti-retroviral ... and anti-retroviral drugs. Other medical research areas include the topics of pre-exposure prophylaxis, post-exposure ...

Antimicrobial Agents and Chemotherapy. 53 (4): 1683-1685. doi:10.1128/AAC.01168-08. PMC 2663123. PMID 19223637. (Articles with ... and difficulty confirming the effectiveness of the drug in patients where other retroviral drugs masked key indicators. In ... "Efficacy and tolerability of 10-day monotherapy with apricitabine in antiretroviral-naive, HIV-infected patients". AIDS. 20 (9 ...

... and highly active anti-retroviral therapy used in the treatment of HIV/AIDS. Of these, amoxicillin-clavulanate is the most ... These agents are poorly tolerated but are still used in some resource-poor areas. In high-resource countries, they have been ... anti-viral antibodies (such as the anti-hepatitis B surface antibody or anti-hepatitis A antibody), or viral DNA/RNA. In early ... Screening consists of a blood test that detects the anti-hepitits D virus antibbody. If anti-hepitits D virus antibody is ...

This virus would later be known as HIV-1, the causative agent behind the outbreak. This discovery allowed for the development ... Professor Barré-Sinoussi believes that scientists have made steady progress given the development of antiretroviral treatment ... Unité de Régulation des Infections Rétrovirales) and Professor at the Institut Pasteur in Paris, France. Born in Paris, France ... they concluded the agent causing this new disease may be a retrovirus but it was not HTLV, the only known retrovirus at the ...

Pugach P, Ketas TJ, Michael E, Moore JP (August 2008). "Neutralizing antibody and anti-retroviral drug sensitivities of HIV-1 ... Other agents are under investigation for their ability to interact with the proteins involved in HIV entry and the possibility ... Aplaviroc, an agent similar to maraviroc and vicriroc. Clinical trials were halted in 2005 over concerns about the drug's ... By blocking this step in HIV's replication cycle, such agents slow the progression from HIV infection to AIDS. There are ...

A key component of these activities has been provision of HIV care including anti-retroviral treatment (ARV) through funding ... understanding of the pathogenesis and related host-mediated pathways associated with common and/or dangerous infectious agents ...

Scott nearly died of Stage IV AIDS in 1995 and credited marijuana with his survival until effective anti-retroviral therapies ... Scott had completed all but a few weeks of the two-year training program when, as he recalls, an agent from the Naval ... Queer Nation organized the action to protest the anti-abortion and anti-gay teachings of O'Connor and the Roman Catholic Church ... Scott credited his use of medical cannabis among the reasons he survived long enough to receive the new anti-retrovirals that ...

... of molecular diagnostic tools have enabled physicians and researchers to monitor the efficacy of treatment with anti-retroviral ... First, the catalog of infectious agents has grown to the point that virtually all of the significant infectious agents of the ... When infection attacks the body, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs ... Second, an infectious agent must grow within the human body to cause disease; essentially it must amplify its own nucleic acids ...