A condition resulting from the excessive retention of water with sodium depletion.
Deficiency of sodium in the blood; salt depletion. (Dorland, 27th ed)
Books designed to give factual information or instructions.
The consumption of liquids.
Members of a religious denomination founded in the United States during the late 19th century in which active evangelism is practiced, the imminent approach of the millennium is preached, and war and organized government authority in matters of conscience are strongly opposed (from American Heritage Dictionary of the English Language, 4th ed). Jehovah's Witnesses generally refuse blood transfusions and other blood-based treatments based on religious belief.
Physiological changes that occur in bodies after death.
The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.
Individuals licensed to practice medicine.
Postmortem examination of the body.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
The abrupt cessation of all vital bodily functions, manifested by the permanent loss of total cerebral, respiratory, and cardiovascular functions.
Refers to the whole process of grieving and mourning and is associated with a deep sense of loss and sadness.
Physicians appointed to investigate all cases of sudden or violent death.
The application of pathology to questions of law.
Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.

Association between preference for sweets and excessive alcohol intake: a review of animal and human studies. (1/53)

This report reviews a series of studies demonstrating a relationship between the consumption of sweets and alcohol consumption. There is consistent evidence linking the consumption of sweets to alcohol intake in both animals and humans, and there are indications that this relationship may be at least partially genetic in nature. Alcohol-preferring rats have a tendency to consume sucrose and saccharin solutions far beyond the limits of their normal fluid intake and this has been proposed to be a model of the clinical phenomenon known as loss of control. Furthermore, rats and mice, genetically bred to prefer alcohol, tend to choose more concentrated sweet solutions, compared to animals which do not prefer alcohol. Similar tendencies to prefer ultra-sweet solutions have been noted in studies of alcoholic subjects, with most alcoholics preferring sweeter sucrose solutions than do controls. Evidence also exists that those alcoholics who prefer sweeter solutions may represent a familial form of alcoholism. Finally, consumption of sweets and/or sweet solutions may significantly suppress alcohol intake in both animals and in alcoholics. Carbohydrate structure and sweet taste may contribute to this effect through different physiological mechanisms involving serotonergic, opioid, and dopaminergic functions. The possibility that there is concordance between sweet liking and alcohol consumption and/or alcoholism has theoretical, biological, and diagnostic/practical implications.  (+info)

Renomedullary and intestinal hyaluronan content during body water excess: a study in rats and gerbils. (2/53)

Our previous studies in rats have suggested a role for renomedullary hyaluronan (HA) in water homeostasis. The gerbil is known for its unique ability to conserve water. In the present study renal papillary and intestinal HA were compared between groups of anaesthetized gerbils and rats before and after up to 6 h of I.V. water loading. Baseline papillary HA in gerbils was only 37 % of that in the rat. Water loading in rats increased the papillary HA content. Elevation was maximal (+27 %, P < 0.05) after 2 h of water loading and then declined to control levels after 6 h of water loading (+3 %, n.s.). In contrast, the gerbil responded with a decreased papillary HA content during water loading. The depression was maximal after 2 h (-49 %, P < 0.05) and was still 41 % below the control values after 6 h (P < 0.05). The urine flow rate increased rapidly in the rat and its maximum, 21 times above the control level (P < 0.05), occurred at the HA peak, i.e. after 2 h of water loading while in the gerbil, the urine flow rate increased slowly and slightly and was only six times above control values after 6 h of water loading (P < 0.05). The HA content along the intestine was similar in the two species: lowest in the duodenum and jejunum and highest in the distal colon. To conclude, in the rat, the elevation of papillary interstitial HA during acute water loading would counteract water reabsorption by changing the physico-chemical characteristics of the interstitial matrix favouring rapid water diuresis. This would work as a complement to the powerful regulation by ADH. The gerbil has a diametrically different regulation of papillary HA turnover during water loading. The decreased papillary HA level during water loading and the slow and small diuretic response may represent a genetic difference in adaptation to enhance the ability to conserve water in an arid environment.  (+info)

Further characterization of the natriuretic factor derived from kidney tissue of volume-expanded rats. Effects on short-circuit current and sodium-potassium-adenosine triphosphatase activity. (3/53)

Boiled homogenates of kidneys from volume-expanded and hydropenic rats were subjected to column chromatography. The fraction eluting within the range of partition coefficients (Kav) 0.76-0.89 (fraction III) was lyophilized and the effects of this semipurified preparation were assessed on short-circuit current (SCC) across isolated frog skin, on rat kidney cortex Na-K-ATPase activity, and on sodium excretion by the rat in vivo. At a dose of 500 mug/ml, fraction III from expanded rat kidney inhibited SCC by 21 +/- 5% (P less than 0.01), whereas the same fraction from hydropenic rat kidney produced an insignificant change in SCC of 2 +/- 8 %. In a dose-response study, 50, 150, 500, and 1,500 mug/ml of fraction III from expanded rat kidney inhibited SCC by 4, 8, 19, and 28%, respectively; 500, 1,000 and 1,500 mug/ml inhibited Na-K-ATPase activity by 11, 22, and 49%, respectively. An identical study with fraction III from hydropenic animals showed no significant effect in either assay. Also, fractions from expanded and hydropenic rats, eluted after fraction III (fractions IV and V), had no effect on SCC or Na-K-ATPase activity. Fraction III also produced significant natriuresis in vivo at a dose of 500 mug/ml, confirming our observations that a natriuretic principle may be recovered from the kidneys of volume-expanded rats. We suggest that this natriuretic principle may act by reducing active sodium transport via inhibition of Na-K-ATPase.  (+info)

Early diagnosis of central pontine myelinolysis with diffusion-weighted imaging. (4/53)

Central pontine myelinolysis (CPM) occurs in the setting of rapidly corrected hyponatremia, especially in chronically debilitated patients. Conventional CT and MR imaging findings lag the clinical manifestations of CPM. We present a case in which restricted diffusion was identified within the central pons by using MR diffusion-weighted imaging within 24 hours of onset of patient tetraplegia and before findings were conspicuous with conventional MR imaging sequences (T1, T2, and fluid-attenuated inversion recovery).  (+info)

Urinary excretion half life of trichloroacetic acid as a biomarker of exposure to chlorinated drinking water disinfection by-products. (5/53)

AIMS: To measure accurately urinary elimination half life of trichloroacetic acid (TCAA). METHODS: A longitudinal pilot exposure/intervention study measured the elimination half life of TCAA in urine. Beverage consumption was limited to a public water supply and bottled water of known TCAA concentration, and ingestion volume was managed. The five participants limited fluid consumption to only the water provided. Consumption journals were kept by each participant and their daily first morning urine (FMU) samples were analysed for TCAA and creatinine. TCAA elimination half life curves were generated from a two week washout period using TCAA-free bottled water. RESULTS: Individual elimination half lives ranged from 2.1 to 6.3 days, for single compartment exponential decay, the model which fit the data. CONCLUSION: Urinary TCAA is persistent enough to be viable as a biomarker of medium term (days) exposure to drinking water TCAA ingestion within a range of realistic concentrations.  (+info)

The dipsomania of great distance: water intoxication in an Ironman triathlete. (6/53)

Of 371 athletes (62% of all finishers) whose weights were measured before and after the 226 km South African Ironman Triathlon, the athlete who gained the most weight (3.6 kg) during the race was the only competitor to develop symptomatic hyponatraemia. During recovery, he excreted an excess of 4.6 litres of urine. This case report again confirms that symptomatic hyponatraemia is caused by considerable fluid overload independent of appreciable NaCl losses. Hence prevention of the condition requires that athletes be warned not to drink excessively large volumes of fluid (dipsomania) during very prolonged exercise. This case report also shows that there is a delayed diuresis in this condition and that it is not caused by renal failure.  (+info)

In vivo measurement of brain extracellular space diffusion by cortical surface photobleaching. (7/53)

Molecular diffusion in the brain extracellular space (ECS) is an important determinant of neural function. We developed a brain surface photobleaching method to measure the diffusion of fluorescently labeled macromolecules in the ECS of the cerebral cortex. The ECS in mouse brain was labeled by exposure of the intact dura to fluorescein-dextrans (M(r) 4, 70, and 500 kDa). Fluorescein-dextran diffusion, detected by fluorescence recovery after laser-induced cortical photobleaching using confocal optics, was slowed approximately threefold in the brain ECS relative to solution. Cytotoxic brain edema (produced by water intoxication) or seizure activity (produced by convulsants) slowed diffusion by >10-fold and created dead-space microdomains in which free diffusion was prevented. The hindrance to diffusion was greater for the larger fluorescein-dextrans. Interestingly, slowed ECS diffusion preceded electroencephalographic seizure activity. In contrast to the slowed diffusion produced by brain edema and seizure activity, diffusion in the ECS was faster in mice lacking aquaporin-4 (AQP4), an astroglial water channel that facilitates fluid movement between cells and the ECS. Our results establish a minimally invasive method to quantify diffusion in the brain ECS in vivo, revealing stimulus-induced changes in molecular diffusion in the ECS with unprecedented spatial and temporal resolution. The in vivo mouse data provide evidence for: (1) dead-space ECS microdomains after brain swelling; (2) slowed molecular diffusion in the ECS as an early predictor of impending seizure activity; and (3) a novel role for AQP4 as a regulator of brain ECS.  (+info)

Crisis management during anaesthesia: water intoxication. (8/53)

BACKGROUND: Irrigation of closed body spaces may lead to substantial perioperative fluid and electrolyte shifts. A syndrome occurring during transurethral resection of prostate (TURP), and a similar syndrome described in women undergoing transcervical endometrial ablation (TCEA) are both characterised by a spectrum of symptoms which may range from asymptomatic hyponatraemia to convulsions, coma, and death. Such potentially serious consequences require prompt recognition and appropriate management of this "water intoxication" syndrome. OBJECTIVES: To examine the role of a previously described core algorithm "COVER ABCD-A SWIFT CHECK", supplemented by a specific sub-algorithm for water intoxication, in the management of this syndrome occurring in association with anaesthesia. METHODS: The potential performance of this structured approach for each of the relevant incidents among the first 4000 reported to the Australian Incident Monitoring Study (AIMS) was compared with the actual management as reported by the anaesthetists involved. RESULTS: From the first 4000 incidents reported to AIMS, 10 reports of water intoxication were identified, two from endometrial ablations under general anaesthesia and eight from male urological procedures under spinal anaesthesia. The "core" crisis management algorithm detected a problem in seven cases; however, it was deficient in dealing with neurological presentations. Diagnosis of the cause of the incident would have required a specific water intoxication sub-algorithm in eight cases and a hypotension algorithm in a further two cases. Corrective strategies also required a specific sub-algorithm in eight cases, while the hypotension and cardiac arrest sub-algorithms were required in conjunction with the water intoxication sub-algorithm in the remaining two. CONCLUSION: This relatively uncommon problem is managed poorly using the "core" crisis management sub-algorithm and requires a simple specific sub-algorithm for water intoxication.  (+info)

Medical Definition of Water Intoxication:

Water intoxication, also known as hyponatremia, is a condition that occurs when an individual consumes water in such large quantities that the body's electrolyte balance is disrupted. This results in an abnormally low sodium level in the blood (hyponatremia), which can cause symptoms ranging from mild to severe, including nausea, headache, confusion, seizures, coma, and even death in extreme cases. It's important to note that water intoxication is rare and typically only occurs in situations where large amounts of water are consumed in a short period of time, such as during endurance sports or when someone is trying to intentionally harm themselves.

Hyponatremia is a condition characterized by abnormally low sodium levels in the blood, specifically levels less than 135 mEq/L. Sodium is an essential electrolyte that helps regulate water balance in and around your cells and plays a crucial role in nerve and muscle function. Hyponatremia can occur due to various reasons, including certain medical conditions, medications, or excessive water intake leading to dilution of sodium in the body. Symptoms may range from mild, such as nausea, confusion, and headache, to severe, like seizures, coma, or even death in extreme cases. It's essential to seek medical attention if you suspect hyponatremia, as prompt diagnosis and treatment are vital for a favorable outcome.

I'm sorry for any confusion, but "Manuals as Topic" is not a recognized medical term or concept. A manual typically refers to a book or guide that provides instructions or information about a particular subject or task. In a medical context, manuals may include clinical practice guidelines, procedural manuals, policy manuals, or training manuals that provide guidance for healthcare professionals in diagnosing, treating, and managing various medical conditions or situations. However, "Manuals as Topic" is too broad and does not refer to a specific medical concept. If you have a more specific question about a particular type of medical manual, I'd be happy to help!

The term "drinking" is commonly used to refer to the consumption of beverages, but in a medical context, it usually refers to the consumption of alcoholic drinks. According to the Merriam-Webster Medical Dictionary, "drinking" is defined as:

1. The act or habit of swallowing liquid (such as water, juice, or alcohol)
2. The ingestion of alcoholic beverages

It's important to note that while moderate drinking may not pose significant health risks for some individuals, excessive or binge drinking can lead to a range of negative health consequences, including addiction, liver disease, heart disease, and increased risk of injury or violence.

I must clarify that "Jehovah's Witnesses" is not a medical term or condition. It is a religious group with specific beliefs and practices, one of which is the refusal of blood transfusions, even in life-threatening situations, due to their interpretation of biblical passages. This can have significant implications for their healthcare and medical decision-making. However, it does not constitute a medical definition.

"Postmortem changes," also known as "autolysis" or "decomposition," refer to the natural biological processes that occur in a deceased body after death. These changes include various chemical, physical, and biological alterations such as livor mortis (pooling of blood), algor mortis (drop in body temperature), rigor mortis (stiffening of muscles), putrefaction (breakdown by microorganisms), and decomposition by insects and other animals. These changes help forensic experts estimate the time since death, known as the postmortem interval.

Tissue and organ procurement is the process of obtaining viable tissues and organs from deceased or living donors for the purpose of transplantation, research, or education. This procedure is performed by trained medical professionals in a sterile environment, adhering to strict medical standards and ethical guidelines. The tissues and organs that can be procured include hearts, lungs, livers, kidneys, pancreases, intestines, corneas, skin, bones, tendons, and heart valves. The process involves a thorough medical evaluation of the donor, as well as consent from the donor or their next of kin. After procurement, the tissues and organs are preserved and transported to recipients in need.

A physician is a healthcare professional who practices medicine, providing medical care and treatment to patients. Physicians may specialize in various fields of medicine, such as internal medicine, surgery, pediatrics, psychiatry, or radiology, among others. They are responsible for diagnosing and treating illnesses, injuries, and disorders; prescribing medications; ordering and interpreting diagnostic tests; providing counseling and education to patients; and collaborating with other healthcare professionals to provide comprehensive care. Physicians may work in a variety of settings, including hospitals, clinics, private practices, and academic medical centers. To become a physician, one must complete a Doctor of Medicine (M.D.) or Doctor of Osteopathic Medicine (D.O.) degree program and pass licensing exams to practice medicine in their state.

An autopsy, also known as a post-mortem examination or obduction, is a medical procedure in which a qualified professional (usually a pathologist) examines a deceased person's body to determine the cause and manner of death. This process may involve various investigative techniques, such as incisions to study internal organs, tissue sampling, microscopic examination, toxicology testing, and other laboratory analyses. The primary purpose of an autopsy is to gather objective evidence about the medical conditions and factors contributing to the individual's demise, which can be essential for legal, insurance, or public health purposes. Additionally, autopsies can provide valuable insights into disease processes and aid in advancing medical knowledge.

Sensitivity and specificity are statistical measures used to describe the performance of a diagnostic test or screening tool in identifying true positive and true negative results.

* Sensitivity refers to the proportion of people who have a particular condition (true positives) who are correctly identified by the test. It is also known as the "true positive rate" or "recall." A highly sensitive test will identify most or all of the people with the condition, but may also produce more false positives.
* Specificity refers to the proportion of people who do not have a particular condition (true negatives) who are correctly identified by the test. It is also known as the "true negative rate." A highly specific test will identify most or all of the people without the condition, but may also produce more false negatives.

In medical testing, both sensitivity and specificity are important considerations when evaluating a diagnostic test. High sensitivity is desirable for screening tests that aim to identify as many cases of a condition as possible, while high specificity is desirable for confirmatory tests that aim to rule out the condition in people who do not have it.

It's worth noting that sensitivity and specificity are often influenced by factors such as the prevalence of the condition in the population being tested, the threshold used to define a positive result, and the reliability and validity of the test itself. Therefore, it's important to consider these factors when interpreting the results of a diagnostic test.

Reproducibility of results in a medical context refers to the ability to obtain consistent and comparable findings when a particular experiment or study is repeated, either by the same researcher or by different researchers, following the same experimental protocol. It is an essential principle in scientific research that helps to ensure the validity and reliability of research findings.

In medical research, reproducibility of results is crucial for establishing the effectiveness and safety of new treatments, interventions, or diagnostic tools. It involves conducting well-designed studies with adequate sample sizes, appropriate statistical analyses, and transparent reporting of methods and findings to allow other researchers to replicate the study and confirm or refute the results.

The lack of reproducibility in medical research has become a significant concern in recent years, as several high-profile studies have failed to produce consistent findings when replicated by other researchers. This has led to increased scrutiny of research practices and a call for greater transparency, rigor, and standardization in the conduct and reporting of medical research.

Sudden death is a term used to describe a situation where a person dies abruptly and unexpectedly, often within minutes to hours of the onset of symptoms. It is typically caused by cardiac or respiratory arrest, which can be brought on by various medical conditions such as heart disease, stroke, severe infections, drug overdose, or trauma. In some cases, the exact cause of sudden death may remain unknown even after a thorough post-mortem examination.

It is important to note that sudden death should not be confused with "sudden cardiac death," which specifically refers to deaths caused by the abrupt loss of heart function (cardiac arrest). Sudden cardiac death is often related to underlying heart conditions such as coronary artery disease, cardiomyopathy, or electrical abnormalities in the heart.

Bereavement is the state of loss or grief experienced when a person experiences the death of a loved one, friend, or family member. It is a normal response to the death of someone close and can involve a range of emotions such as sadness, anger, guilt, and anxiety. The grieving process can be different for everyone and can take time to work through. Professional support may be sought to help cope with the loss.

A coroner and medical examiner are officials in the legal system who are responsible for investigating and determining the cause of death in certain cases. While their roles can overlap, there are some differences between them.

A coroner is a public official who is typically appointed or elected to serve in a particular jurisdiction, such as a county or district. The coroner's primary responsibility is to investigate any sudden, unexpected, or suspicious deaths that occur within their jurisdiction. This may include deaths that occur due to violence, accidents, suicide, or unknown causes.

In order to determine the cause of death, the coroner may conduct an autopsy, order toxicology tests, and review medical records and other evidence. The coroner may also hold an inquest, which is a formal hearing in which witnesses are called to testify about the circumstances surrounding the death. Based on the evidence gathered during the investigation, the coroner will make a determination as to the cause and manner of death.

A medical examiner, on the other hand, is a physician who has completed specialized training in forensic pathology. Medical examiners are typically appointed or hired by a government agency, such as a state or county, to perform autopsies and investigate deaths.

Medical examiners are responsible for determining the cause of death in cases where there is a suspicion of foul play, as well as in other circumstances where the cause of death may not be immediately apparent. They may also testify in court as expert witnesses based on their findings.

In some jurisdictions, the roles of coroner and medical examiner are combined, with the official serving as both a public administrator and a trained physician. In other cases, the two roles are separate, with the coroner responsible for administrative functions and the medical examiner responsible for determining the cause of death.

Forensic pathology is a subspecialty of pathology that focuses on determining the cause and manner of death by examining a corpse. It involves applying scientific knowledge and techniques to investigate criminal or suspicious deaths, often in conjunction with law enforcement agencies. A forensic pathologist performs autopsies (postmortem examinations) to evaluate internal and external injuries, diseases, and other conditions that may have contributed to the individual's death. They also collect evidence such as tissue samples, which can be used for toxicological, microbiological, or histological analysis. The information gathered by forensic pathologists is crucial in helping to establish the facts surrounding a person's death and assisting legal proceedings.

The "cause of death" is a medical determination of the disease, injury, or event that directly results in a person's death. This information is typically documented on a death certificate and may be used for public health surveillance, research, and legal purposes. The cause of death is usually determined by a physician based on their clinical judgment and any available medical evidence, such as laboratory test results, autopsy findings, or eyewitness accounts. In some cases, the cause of death may be uncertain or unknown, and the death may be classified as "natural," "accidental," "homicide," or "suicide" based on the available information.

"Terminology as a topic" in the context of medical education and practice refers to the study and use of specialized language and terms within the field of medicine. This includes understanding the meaning, origins, and appropriate usage of medical terminology in order to effectively communicate among healthcare professionals and with patients. It may also involve studying the evolution and cultural significance of medical terminology. The importance of "terminology as a topic" lies in promoting clear and accurate communication, which is essential for providing safe and effective patient care.

No FAQ available that match "water intoxication"

No images available that match "water intoxication"