(Z)-9-Octadecenoic acid 1,2,3-propanetriyl ester.
An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. It is produced by glands on the tongue and by the pancreas and initiates the digestion of dietary fats. (From Dorland, 27th ed) EC 3.1.1.3.
Colloids formed by the combination of two immiscible liquids such as oil and water. Lipid-in-water emulsions are usually liquid, like milk or lotion. Water-in-lipid emulsions tend to be creams. The formation of emulsions may be aided by amphiphatic molecules that surround one component of the system to form MICELLES.
Blocking of a blood vessel by fat deposits in the circulation. It is often seen after fractures of large bones or after administration of CORTICOSTEROIDS.
Triglycerides are the most common type of fat in the body, stored in fat cells and used as energy; they are measured in blood tests to assess heart disease risk, with high levels often resulting from dietary habits, obesity, physical inactivity, smoking, and alcohol consumption.
Scandium. An element of the rare earth family of metals. It has the atomic symbol Sc, atomic number 21, and atomic weight 45.
Colipase I and II, consisting of 94-95 and 84-85 amino acid residues, respectively, have been isolated from porcine pancreas. Their role is to prevent the inhibitory effect of bile salts on the lipase-catalyzed intraduodenal hydrolysis of dietary long-chain triglycerides.
An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. The enzyme hydrolyzes triacylglycerols in chylomicrons, very-low-density lipoproteins, low-density lipoproteins, and diacylglycerols. It occurs on capillary endothelial surfaces, especially in mammary, muscle, and adipose tissue. Genetic deficiency of the enzyme causes familial hyperlipoproteinemia Type I. (Dorland, 27th ed) EC 3.1.1.34.
A 9-kDa protein component of VERY-LOW-DENSITY LIPOPROTEINS. It contains a cofactor for LIPOPROTEIN LIPASE and activates several triacylglycerol lipases. The association of Apo C-II with plasma CHYLOMICRONS; VLDL, and HIGH-DENSITY LIPOPROTEINS is reversible and changes rapidly as a function of triglyceride metabolism. Clinically, Apo C-II deficiency is similar to lipoprotein lipase deficiency (HYPERLIPOPROTEINEMIA TYPE I) and is therefore called hyperlipoproteinemia type IB.
Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a choline moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and choline and 2 moles of fatty acids.
A group of fatty acids that contain 18 carbon atoms and a double bond at the omega 9 carbon.
The interstitial fluid that is in the LYMPHATIC SYSTEM.
A class of lipoproteins that carry dietary CHOLESTEROL and TRIGLYCERIDES from the SMALL INTESTINE to the tissues. Their density (0.93-1.006 g/ml) is the same as that of VERY-LOW-DENSITY LIPOPROTEINS.
The selectively permeable barrier, in the EYE, formed by the nonpigmented layer of the EPITHELIUM of the CILIARY BODY, and the ENDOTHELIUM of the BLOOD VESSELS of the IRIS. TIGHT JUNCTIONS joining adjacent cells keep the barrier between cells continuous.
Enzymes which catalyze the hydrolysis of carboxylic acid esters with the formation of an alcohol and a carboxylic acid anion.
Uptake of substances through the lining of the INTESTINES.
An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed)
Salts and esters of the 18-carbon saturated, monocarboxylic acid--stearic acid.
Fatty acid esters of cholesterol which constitute about two-thirds of the cholesterol in the plasma. The accumulation of cholesterol esters in the arterial intima is a characteristic feature of atherosclerosis.
The metabolic process of breaking down LIPIDS to release FREE FATTY ACIDS, the major oxidative fuel for the body. Lipolysis may involve dietary lipids in the DIGESTIVE TRACT, circulating lipids in the BLOOD, and stored lipids in the ADIPOSE TISSUE or the LIVER. A number of enzymes are involved in such lipid hydrolysis, such as LIPASE and LIPOPROTEIN LIPASE from various tissues.

Oxidation of medium-chain acyl-CoA esters by extracts of Aspergillus niger: enzymology and characterization of intermediates by HPLC. (1/302)

The activities of beta-oxidation enzymes were measured in extracts of glucose- and triolein-grown cells of Aspergillus niger. Growth on triolein stimulated increased enzyme activity, especially for acyl-CoA dehydrogenase. No acyl-CoA oxidase activity was detected. HPLC analysis after incubation of triolein-grown cell extracts with decanoyl-CoA showed that beta-oxidation was limited to one cycle. Octanoyl-CoA accumulated as the decanoyl-CoA was oxidized. Beta-oxidation enzymes in isolated mitochondrial fractions were also studied. The results are discussed in the context of methyl ketone production by fungi.  (+info)

Pancreatic lipase/colipase-mediated triacylglycerol hydrolysis is required for cholesterol transport from lipid emulsions to intestinal cells. (2/302)

This study tested the hypothesis that dietary cholesterol uptake by intestinal cells is dependent on the structure and composition of the lipid carriers in the extracellular milieu. In in vivo experiments with female C57BL/6 mice, cholesterol absorption from phospholipid/triacylglycerol emulsions was significantly reduced by administration of tetrahydrolipstatin, an inhibitor of pancreatic lipase. This inhibitor had no effect on the absorption of cholesterol from phospholipid vesicles. The importance of pancreatic-lipase-mediated triacylglycerol hydrolysis for cholesterol transport from emulsions to intestinal cells was confirmed by in vitro experiments with rat IEC-6 intestinal cells. Cellular uptake of cholesterol from emulsions with a phospholipid/triacylglycerol molar ratio of <0.3 could be stimulated by pancreatic lipase/colipase hydrolysis of the core neutral lipids. However, pancreatic lipase/colipase was ineffective in hydrolysing triacylglycerols in emulsions with a phospholipid/triacylglycerol molar ratio of >0.3. Phospholipase A2-mediated hydrolysis of the surface phospholipids was necessary prior to triacylglycerol hydrolysis in these phospholipid-rich emulsions and to the stimulation of cholesterol transport from these particles to IEC-6 cells. The data also revealed that minimal triacylglycerol hydrolysis was sufficient to significantly increase cholesterol transport from lipid emulsions to the intestinal cells. Thus the products of triacylglycerol hydrolysis, namely monoacylglycerol and non-esterified fatty acids, are key determinants in mediating cholesterol transport from lipid emulsions to intestinal cells. Taken together, these results support the hypothesis that remodelling of the surface and core components of lipid carriers is necessary prior to absorption of dietary cholesterol from the gastrointestinal tract.  (+info)

Preventing neurodegeneration in the Drosophila mutant bubblegum. (3/302)

The Drosophila melanogaster recessive mutant bubblegum (bgm) exhibits adult neurodegeneration, with marked dilation of photoreceptor axons. The bubblegum mutant shows elevated levels of very long chain fatty acids (VLCFAs), as seen in the human disease adrenoleukodystrophy (ALD). In ALD, the excess can be lowered by dietary treatment with "Lorenzo's oil," a mixture of unsaturated fatty acids. Feeding the fly mutant one of the components, glyceryl trioleate oil, blocked the accumulation of excess VLCFAs as well as development of the pathology. Mutant flies thus provide a potential model system for studying mechanisms of neurodegenerative disease and screening drugs for treatment.  (+info)

The movement of an unemulsified oil test meal and aqueous- and oil-phase markers through the intestine of normal and bile-diverted rats. (4/302)

An unemulsified oil test meal containing aqueous- and oil-phase markers (PEG and 3-H labelled triether) was fed to control and bile fustula rats. PEG moved ahead of the lipid phase in all groups, and was of limited value as a marker for the test meal. Triether was an excellent marker for studies of gastric emptying. An unexpectedly high correlation was seen between the triether and the test meal and its digestion products in the intestine. The results suggest that triether is a valid marker for following the movement of lipid through the bowel under the conditions of this study. Triether/fat ratios indicated that fat absorption occurred largely from the upper small bowel in control animals and from the lower small bowel in the absence of bile. Bile diversion resulted in more rapid gastric emptying initially, but very slow gastric emptying of the last part of the oil test meal. Intestinal transit of test meal or either marker was not significantly affected by bile diversion. No evidence for a direct effect of bile diversion on gastrointestinal motility was found.  (+info)

Progression of abnormalities in adrenomyeloneuropathy and neurologically asymptomatic X-linked adrenoleukodystrophy despite treatment with "Lorenzo's oil". (5/302)

OBJECTIVES: X-linked adrenoleukodystrophy (X-ALD) is an inherited disorder of peroxisomal fatty acid oxidation, biochemically characterised by the accumulation of saturated very long chain fatty acids (VLCFAs), particularly hexacosanoic acid (C26:0). Dietary treatment with a 4:1 mixture of glyceroltrioleate and glyceroltrierucate ("Lorenzo's oil") normalises plasma VLCFA concentrations, but neither ameliorates nor arrests the rapid progression of neurological symptoms in the cerebral variants of X-ALD. The efficacy of "Lorenzo's oil" in the milder phenotypes of X-ALD was assessed, as this has been much less investigated. METHODS: Twenty two patients who were treated with "Lorenzo's oil" for at least 12 months for a median period of 2.5 (range 1.0-6.0) years were studied. Two had asymptomatic ALD, four the "Addison only" variant, 13 adrenomyeloneuropathy (AMN), and three were symptomatic female carriers. RESULTS: The plasma C26:0 concentration normalised or near normalised in 19 patients (86%), in the three others it decreased significantly. Nevertheless, disability as measured with the extended disability status scale score increased mildly (0.5 (95% confidence interval (95% CI) 0.25-1.0)) in the 16 patients with neurological symptoms. Furthermore, one "Addison only" patient and one patient with AMN developed cerebral demyelination, and another "Addison only" patient developed AMN. Adrenocortical insufficiency evolved in one patient with AMN, and hypogonadism in one patient with asymptomatic ALD and two patients with AMN. Nerve conduction, evoked potential studies (SEP, BAEP, VEP), and abnormalities on cerebral MRI did not improve. On the other hand, side effects were often noted-namely, mild increases in liver enzymes (55%), thrombocytopenia (55%), gastrointestinal complaints (14%), and gingivitis (14%). We also found a mild decrease in haemoglobin concentration and leucocyte count. CONCLUSIONS: The data suggest that treatment with "Lorenzo's oil" neither improved neurological or endocrine function nor arrested progression of the disease. Furthermore, the oil often induced adverse effects. Therefore, it is advocated that "Lorenzo's oil" should not be prescribed routinely to patients with X-ALD who already have neurological deficits.  (+info)

Effect of increasing lipid loads on the ability of the endoplasmic reticulum to transport lipid to the Golgi. (6/302)

We have previously shown (Mansbach, C. M. and P. J. Nevin, 1998. J. Lipid Res. 39: 963;-968) that after the development of a mass steady state with respect to triacylglycerol absorption in rats, the introduction of radiolabeled trioleoylglycerol, while maintaining the input rate of trioleoylglycerol constant at 135 micromol/h, was followed by a slow (60 min) achievement of a radiolabel steady state in the intestinal endoplasmic reticulum (ER). We hypothesized that this was due to the large input load and that the time to steady state would be shorter at lower lipid loads. Rats were infused intraduodenally with 22.5, 45, 90, or 135 micromol trioleoylglycerol/h for 6 h to obtain a mass steady state in the intestine. [(3)H]trioleoylglycerol was added to the infusate and the ER and Golgi were isolated from the proximal intestine after 5;-60 min of radiolabel infusion. The time required to reach a radiolabel steady state in the ER lengthened from 10 min at the 22.5 micromol/h infusion rate to 60 min at the 135 micromol/h rate. Similar data were obtained for the Golgi. Incubation of the ER with lipase reduced the ER;-triacylglycerol amount by 43% and increased its specific activity by 73%. The amount of [(3)H]TG-dpm in the ER was not reduced unless taurocholate, 10 mm, and colipase were added. We conclude that as the rate of triacylglycerol infusion is increased, TG movement from the ER to the Golgi progressively lengthens until finally all the triacylglycerol infused cannot be transported. A portion of this triacylglycerol is disposed on the cytoplasmic face of the ER and thus able to be attacked by lipase whereas another fraction is sequestered in the ER lumen and immune to lipase attack unless the ER membrane is solubilized.  (+info)

Utilization of very low density lipoprotein by rat heart: the effect of endotoxin. (7/302)

The effect of endotoxin on myocardial utilization of very low density lipoprotein (VLDL) triacylglycerol (TAG) was studied. VLDL was prepared by rat liver perfusion and tested as substrate in the isolated working rat heart. Both liver and heart donor rats were pretreated in vivo with endotoxin or vehicle (control). VLDL-TAG synthesized by endotoxin-pretreated livers was assimilated and oxidized at an increased rate by hearts compared with control VLDL-TAG, regardless of the cardiac endotoxic status, with increased cardiac mechanical performance (cardiac output, hydraulic work). There was no change in incorporation of labeled VLDL lipids into myocardial tissue lipids. Lipoprotein lipase (LPL) activity was increased in endotoxin-pretreated hearts, and after perfusion with "endotoxic" VLDL, there was a tendency for translocation of LPL from tissue-residual to heparin-releasable compartments, but these changes were modest. Analysis of the VLDL composition showed that endotoxin-pretreated livers produced apolipoprotein (apo)-B48 VLDL with decreased particle size (and hence TAG content), but apo-B100 VLDL was unchanged. Oleate content of VLDL was increased, but there was no difference in apo-C or apo-E content. These results suggest that VLDL-TAG produced during sepsis/endotoxinemia may be destined for utilization by the heart as energy substrate. However, the mechanism for its increased efficacy is uncertain.  (+info)

Screening of environmental DNA libraries for the presence of genes conferring lipolytic activity on Escherichia coli. (8/302)

Environmental DNA libraries prepared from three different soil samples were screened for genes conferring lipolytic activity on Escherichia coli clones. Screening on triolein agar revealed 1 positive clone out of 730,000 clones, and screening on tributyrin agar revealed 3 positive clones out of 286,000 E. coli clones. Substrate specificity analysis revealed that one recombinant strain harbored a lipase and the other three contained esterases. The genes responsible for the lipolytic activity were identified and characterized.  (+info)

Triolein is a type of triglyceride, which is a kind of fat molecule. More specifically, triolein is the triglyceride formed from three molecules of oleic acid, a common monounsaturated fatty acid. It is often used in scientific research and studies involving lipid metabolism, and it can be found in various vegetable oils and animal fats.

Lipase is an enzyme that is produced by the pancreas and found in the digestive system of most organisms. Its primary function is to catalyze the hydrolysis of fats (triglycerides) into smaller molecules, such as fatty acids and glycerol, which can then be absorbed by the intestines and utilized for energy or stored for later use.

In medical terms, lipase levels in the blood are often measured to diagnose or monitor conditions that affect the pancreas, such as pancreatitis (inflammation of the pancreas), pancreatic cancer, or cystic fibrosis. Elevated lipase levels may indicate damage to the pancreas and its ability to produce digestive enzymes.

An emulsion is a type of stable mixture of two immiscible liquids, such as oil and water, which are normally unable to mix together uniformly. In an emulsion, one liquid (the dispersed phase) is broken down into small droplets and distributed throughout the other liquid (the continuous phase), creating a stable, cloudy mixture.

In medical terms, emulsions can be used in various pharmaceutical and cosmetic applications. For example, certain medications may be formulated as oil-in-water or water-in-oil emulsions to improve their absorption, stability, or palatability. Similarly, some skincare products and makeup removers contain emulsifiers that help create stable mixtures of water and oils, allowing for effective cleansing and moisturizing.

Emulsions can also occur naturally in the body, such as in the digestion of fats. The bile salts produced by the liver help to form small droplets of dietary lipids (oil) within the watery environment of the small intestine, allowing for efficient absorption and metabolism of these nutrients.

Fat embolism is a medical condition that occurs when fat globules enter the bloodstream and block small blood vessels (arterioles and capillaries) in various tissues and organs. This can lead to inflammation, tissue damage, and potentially life-threatening complications.

Fat embolism typically occurs as a result of trauma, such as long bone fractures or orthopedic surgeries, where fat cells from the marrow of the broken bone enter the bloodstream. It can also occur in other conditions that cause fat to be released into the circulation, such as pancreatitis, decompression sickness, and certain medical procedures like liposuction.

Symptoms of fat embolism may include respiratory distress, fever, confusion, petechial rash (small purple or red spots on the skin), and a decrease in oxygen levels. In severe cases, it can lead to acute respiratory distress syndrome (ARDS) and even death. Treatment typically involves supportive care, such as oxygen therapy, mechanical ventilation, and medications to manage symptoms and prevent complications.

Triglycerides are the most common type of fat in the body, and they're found in the food we eat. They're carried in the bloodstream to provide energy to the cells in our body. High levels of triglycerides in the blood can increase the risk of heart disease, especially in combination with other risk factors such as high LDL (bad) cholesterol, low HDL (good) cholesterol, and high blood pressure.

It's important to note that while triglycerides are a type of fat, they should not be confused with cholesterol, which is a waxy substance found in the cells of our body. Both triglycerides and cholesterol are important for maintaining good health, but high levels of either can increase the risk of heart disease.

Triglyceride levels are measured through a blood test called a lipid panel or lipid profile. A normal triglyceride level is less than 150 mg/dL. Borderline-high levels range from 150 to 199 mg/dL, high levels range from 200 to 499 mg/dL, and very high levels are 500 mg/dL or higher.

Elevated triglycerides can be caused by various factors such as obesity, physical inactivity, excessive alcohol consumption, smoking, and certain medical conditions like diabetes, hypothyroidism, and kidney disease. Medications such as beta-blockers, steroids, and diuretics can also raise triglyceride levels.

Lifestyle changes such as losing weight, exercising regularly, eating a healthy diet low in saturated and trans fats, avoiding excessive alcohol consumption, and quitting smoking can help lower triglyceride levels. In some cases, medication may be necessary to reduce triglycerides to recommended levels.

I'm sorry for any confusion, but "Scandium" is not a medical term. It is a chemical element with the symbol Sc and atomic number 21. It is a silvery-white metal that is soft, workable, and highly resistant to corrosion. In medicine, scandium and its compounds are not used in therapy or diagnosis.

Colipases are small protein enzymes that activate and work together with pancreatic lipases to digest dietary fats in the small intestine. They are produced by the pancreas and secreted into the duodenum as part of the pancreatic juice. Colipases help to stabilize and orient the lipase enzyme on the surface of fat droplets, allowing it to efficiently hydrolyze triacylglycerols into monoacylglycerols, free fatty acids, and glycerol. This process is crucial for the absorption of dietary fats in the human body.

Lipoprotein lipase (LPL) is an enzyme that plays a crucial role in the metabolism of lipids. It is responsible for breaking down triglycerides, which are the main constituent of dietary fats and chylomicrons, into fatty acids and glycerol. These products are then taken up by cells for energy production or storage.

LPL is synthesized in various tissues, including muscle and fat, where it is attached to the inner lining of blood vessels (endothelium). The enzyme is activated when it comes into contact with lipoprotein particles, such as chylomicrons and very-low-density lipoproteins (VLDL), which transport triglycerides in the bloodstream.

Deficiencies or mutations in LPL can lead to various metabolic disorders, including hypertriglyceridemia, a condition characterized by high levels of triglycerides in the blood. Conversely, overexpression of LPL has been associated with increased risk of atherosclerosis due to excessive uptake of fatty acids by macrophages and their conversion into foam cells, which contribute to plaque formation in the arteries.

Apolipoprotein C-II (ApoC-II) is a type of apolipoprotein, which are proteins that bind to lipids to form lipoprotein complexes. ApoC-II is a component of several lipoproteins, including very low-density lipoproteins (VLDL) and chylomicrons, which are responsible for the transport of fat molecules, such as triglycerides and cholesterol, in the bloodstream.

ApoC-II plays a crucial role in the activation of lipoprotein lipase, an enzyme that breaks down triglycerides in VLDL and chylomicrons into fatty acids, which can then be taken up by cells for energy production or storage. Therefore, ApoC-II deficiency can lead to hypertriglyceridemia, a condition characterized by high levels of triglycerides in the blood.

In addition to its role in lipid metabolism, ApoC-II has been implicated in the development and progression of atherosclerosis, a chronic inflammatory disease that affects the arteries and can lead to serious cardiovascular complications, such as heart attack and stroke.

Phosphatidylcholines (PtdCho) are a type of phospholipids that are essential components of cell membranes in living organisms. They are composed of a hydrophilic head group, which contains a choline moiety, and two hydrophobic fatty acid chains. Phosphatidylcholines are crucial for maintaining the structural integrity and function of cell membranes, and they also serve as important precursors for the synthesis of signaling molecules such as acetylcholine. They can be found in various tissues and biological fluids, including blood, and are abundant in foods such as soybeans, eggs, and meat. Phosphatidylcholines have been studied for their potential health benefits, including their role in maintaining healthy lipid metabolism and reducing the risk of cardiovascular disease.

Oleic acid is a monounsaturated fatty acid that is commonly found in various natural oils such as olive oil, sunflower oil, and grapeseed oil. Its chemical formula is cis-9-octadecenoic acid, and it is a colorless liquid at room temperature. Oleic acid is an important component of human diet and has been shown to have potential health benefits, including reducing the risk of heart disease and improving immune function. It is also used in the manufacture of soaps, cosmetics, and other personal care products.

Lymph is a colorless, transparent fluid that circulates throughout the lymphatic system, which is a part of the immune and circulatory systems. It consists of white blood cells called lymphocytes, proteins, lipids, glucose, electrolytes, hormones, and waste products. Lymph plays an essential role in maintaining fluid balance, absorbing fats from the digestive tract, and defending the body against infection by transporting immune cells to various tissues and organs. It is collected from tissues through lymph capillaries and flows through increasingly larger lymphatic vessels, ultimately returning to the bloodstream via the subclavian veins in the chest region.

Chylomicrons are a type of lipoprotein that are responsible for carrying dietary lipids, such as triglycerides and cholesterol, from the intestines to other parts of the body through the lymphatic system and bloodstream. They are the largest lipoproteins and are composed of an outer layer of phospholipids, free cholesterol, and apolipoproteins, which surrounds a core of triglycerides and cholesteryl esters. Chylomicrons are produced in the intestinal mucosa after a meal containing fat, and their production is stimulated by the hormone cholecystokinin. Once in the bloodstream, chylomicrons interact with other lipoproteins and enzymes to deliver their lipid cargo to various tissues, including muscle and adipose tissue, where they are used for energy or stored for later use.

The blood-aqueous barrier (BAB) is a specialized structure in the eye that helps regulate the exchange of nutrients, oxygen, and waste products between the bloodstream and the anterior chamber of the eye. It is composed of two main components: the nonpigmented epithelial cells of the ciliary body and the endothelial cells of the iris vasculature.

The nonpigmented epithelial cells of the ciliary body form a tight junction that separates the anterior chamber from the ciliary blood vessels, while the endothelial cells lining the iris blood vessels also have tight junctions that restrict the movement of molecules between the blood and the anterior chamber.

The BAB helps maintain the homeostasis of the anterior chamber by controlling the entry of immune cells and preventing the passage of large molecules, toxins, and pathogens from the bloodstream into the eye. Dysfunction of the BAB can lead to various ocular diseases such as uveitis, glaucoma, and age-related macular degeneration.

Carboxylic ester hydrolases are a class of enzymes that catalyze the hydrolysis of ester bonds in carboxylic acid esters, producing alcohols and carboxylates. This group includes several subclasses of enzymes such as esterases, lipases, and thioesterases. These enzymes play important roles in various biological processes, including metabolism, detoxification, and signal transduction. They are widely used in industrial applications, such as the production of biodiesel, pharmaceuticals, and food ingredients.

Intestinal absorption refers to the process by which the small intestine absorbs water, nutrients, and electrolytes from food into the bloodstream. This is a critical part of the digestive process, allowing the body to utilize the nutrients it needs and eliminate waste products. The inner wall of the small intestine contains tiny finger-like projections called villi, which increase the surface area for absorption. Nutrients are absorbed into the bloodstream through the walls of the capillaries in these villi, and then transported to other parts of the body for use or storage.

Oleic acid is a monounsaturated fatty acid that is commonly found in various natural oils such as olive oil, sunflower oil, and peanut oil. Its chemical formula is cis-9-octadecenoic acid, and it is a colorless liquid at room temperature with a slight odor. Oleic acid is an important component of human diet and has been shown to have various health benefits, including reducing the risk of heart disease and improving immune function. It is also used in the manufacture of soaps, cosmetics, and other industrial products.

Stearates are salts or esters of stearic acid, a saturated fatty acid with 18 carbons. In a medical context, stearates are often used as excipients in pharmaceutical and nutritional supplement formulations. They act as lubricants, helping to improve the flow properties of powders and facilitating the manufacturing process. Common examples include magnesium stearate and calcium stearate. However, it is important to note that there has been some controversy regarding the use of stearates in nutritional supplements, with concerns that they may reduce the bioavailability of certain active ingredients.

Cholesteryl esters are formed when cholesterol, a type of lipid (fat) that is important for the normal functioning of the body, becomes combined with fatty acids through a process called esterification. This results in a compound that is more hydrophobic (water-repelling) than cholesterol itself, which allows it to be stored more efficiently in the body.

Cholesteryl esters are found naturally in foods such as animal fats and oils, and they are also produced by the liver and other cells in the body. They play an important role in the structure and function of cell membranes, and they are also precursors to the synthesis of steroid hormones, bile acids, and vitamin D.

However, high levels of cholesteryl esters in the blood can contribute to the development of atherosclerosis, a condition characterized by the buildup of plaque in the arteries, which can increase the risk of heart disease and stroke. Cholesteryl esters are typically measured as part of a lipid profile, along with other markers such as total cholesterol, HDL cholesterol, and triglycerides.

Lipolysis is the process by which fat cells (adipocytes) break down stored triglycerides into glycerol and free fatty acids. This process occurs when the body needs to use stored fat as a source of energy, such as during fasting, exercise, or in response to certain hormonal signals. The breakdown products of lipolysis can be used directly by cells for energy production or can be released into the bloodstream and transported to other tissues for use. Lipolysis is regulated by several hormones, including adrenaline (epinephrine), noradrenaline (norepinephrine), cortisol, glucagon, and growth hormone, which act on lipases, enzymes that mediate the breakdown of triglycerides.

... is also known as glyceryl trioleate and is one of the two components of Lorenzo's oil. The oxidation of triolein is ... Triolein is a symmetrical triglyceride derived from glycerol and three units of the unsaturated fatty acid oleic acid. Most ...
Relationship to cholesteryl oleate and triolein hydrolase activities". Biochim. Biophys. Acta. 794 (3): 419-27. doi:10.1016/ ...
The example below shows the reaction of triolein with ozone and ethylene glycol. Air oxidation, (autoxidation), the chemistry ...
Thus, if olive oil were pure triolein, it would solidify in a properly set refrigerator. However, olive oil is a complex ... triolein) has a melting point of 5 ˚C, which is slightly above the high end of proper refrigerator temperature. ...
... is also formed during deep frying of corn oil, cottonseed oil, trilinolein, and triolein. Butan-1-ol is one of the " ...
3S,5R,6E,8E)-Deca-6,8-dien-1,3,5-triol, ein neues Stoffwechselprodukt vonStreptomyces fimbriatus (MILLARDet BURR 1926)". ...
SPMDs can accumulate contaminants from the water column because of triolein (glyceryl trioleate) comprising the lipid membrane ...
SPMDs are composed of sealed plastic tubing filled with triolein, in which nonpolar organics are very soluble and which serves ... For example, the SPMD sampler uses a semipermeable membrane and triolein (a triglyceride), both of which mimic toxicant uptake ...
... and triolein to reproduce the chewy, gelatinous texture of shark fins. However, some of these imitations absorb the broth more ...
Those subjects with high CD36 expression were eight times more sensitive to certain fats (oleic acid and triolein) than the ...
For instance, triolein, a triglyceride occurring in many fats and oils, has three oleic acid residues esterified to a molecule ...
... triolein hydrolase, tween-hydrolyzing esterase, amano CE, cacordase, triglyceridase, triacylglycerol ester hydrolase, amano P, ...
... triolein MeSH D10.251.122.572 - octanoic acids MeSH D10.251.175.200 - decanoates MeSH D10.251.220.700 - phytanic acid MeSH ... triolein MeSH D10.390.470.025 - acidic glycosphingolipids MeSH D10.390.470.025.060 - antigens, cd15 MeSH D10.390.470.025.475 - ...
Triolein is also known as glyceryl trioleate and is one of the two components of Lorenzos oil. The oxidation of triolein is ... Triolein is a symmetrical triglyceride derived from glycerol and three units of the unsaturated fatty acid oleic acid. Most ...
"Triolein" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject Headings ... This graph shows the total number of publications written about "Triolein" by people in UAMS Profiles by year, and whether " ... Below are the most recent publications written about "Triolein" by people in Profiles over the past ten years. ...
All you need to know about Triolein, its properties and its uses in skin care and cosmetics ... Glycerol trioleate also is known as triolein, is a monoacid triglyceride. It comes as a clear pale-yellow viscous liquid. It is ...
Dive into the research topics of Mathematical model for stepwise hydrolysis of triolein using Candida rugosa lipase in ... Mathematical model for stepwise hydrolysis of triolein using Candida rugosa lipase in biphasic oil-water system. ...
13C-triolein, 13C-tripalmitin, 13C-trioctanoin, or 13C-hiolen, for lipase activity; 13C-cholesteryl octanoate, for esterase ...
Standard curve was drawn using different concentrations (1, 2, 5, 10, and 20 mg/mL) of triolein. D. tertiolecta culture (1.5 10 ... was added to 5 mL of triolein and solution mixed and incubated at room temperature for 10 min. ...
... absorption of leucine plus triolein was increased after duodenal administration in GLP-2-treated mice (P , 0.01-0.001). Finally ...
Among the triglycerides tested, triolein was the most effective, with a 50-fold increase in LipL production. A Northern blot ...
Isostearyl Alcohol, Isopropyl Palmitate, Octyldodecanol, Triolein, Octocrylene, Homosalate, Ethylhexyl Salicylate, Butyl ...
2. A yellow oily liquid that occurs naturally in most fats; triolein: Oleic is mainly used as a textile lubricant. 3. The ...
3.996% Triolein:. Proven to deliver instant and long term moisturization. Triolein works in tandem with squalane and glycerine ... Aqua (Water/Eau), Squalane, Triolein, Glycerin, Glyceryl Oleate Citrate, Caprylic/Capric Triglyceride, Magnesium Aluminum ...
are unaffected from elevated concentrations of bilirubin, hemoglobin, and triolein.. HIV 1/2 Elisa Related Kits:. HIV 1,2 Ab/Ag ...
... triolein and tricaprylin). The particles typically consist of ,97% water (with dissolved drug) and 1% to 3% lipids, and are ...
High Pressure Research Raman spectroscopy of triolein under high pressures. *Journal of Physics A: Mathematical and Theoretical ...
This project aims to lay the groundwork for kinetic studies of the catalytic conversion of pure triolein (a model compound of ...
When a [3H]triolein emulsion with either cholylsarcosine or cholyltaurine was infused intraduodenally in biliary fistula rats, ...
However, data from indirect calorimetry and oxidation of [1-14C]-triolein to 14CO2 showed that addition of 5.4% RS to the diet ... In fact, postprandial oxidation of [1-14C]-triolein was 23% greater with the 5.4% RS meal than the 0% meal (p = 0.0062). These ... The 0%, 5.4%, and 10.7% meals contained 50 μCi [1-14C]-triolein with breath samples collected hourly following the meal, and ... It must be noted that the calculation of oxidation of [14C]-triolein via measurement of 14CO2 did not take into account the ...
TRIOLEIN Extraction: Triolein, also known as triolein, is a triglyceride of oleic acid and represents 4-30% of olive oil. It is ... Triolein , Kaolin , Parfum*** , Silybum Marianum Ethyl Ester , Hydrogenated Olive Oil Unsaponifiables , Coco-Caprylate/Caprate ...
45% saturated fatty acid-rich high fat diet (HFD-SFA) with 15% triolein & 10% lard ...
A mixture of 45-nm particles labeled with [3H]triolein and [14C]-labeled oleate was used as infusate. After 2 h of infusion, ... Kinetic behavior of TG and FA tracers after a bolus injection of a mixture of rat chylomicrons labeled with [3H]triolein and ... Kinetic behavior of TG and FA tracers after a bolus injection of a mixture of rat chylomicrons labeled with [3H]triolein and ... Chylomicrons and lipid emulsions were labeled with [3H]triolein, injected into mice, and appearance in plasma of [3H]oleic acid ...
Triolein, Maltodextrin, Bisabolol, Xanthan Gum, Cetearyl Alcohol, Myristic Acid, Tetrasodium Glutamate Diacetate, ...
... and triolein, in varying concentrations. Analysts following ASTM D6584 are required to prepare five different multi-component ...
Triolein, Beta-Glucan, Aloe Barbadensis Leaf Juice, Maltodextrin, Xanthan Gum, 1,2-Hexanediol, Acrylates/C10-30 Alkyl Acrylate ... Triolein, Trilinolein, Polyquaternium-10, Methyl Gluceth-20, Sodium Benzotriazolyl Butylphenol Sulfonate, Buteth-3, Tributyl ...
Triolein, Palmitoyl Tripeptide-5, Palmitic Acid, Polygonatum Officinale Rhizome/Root Extract, Arnica Montana (Arnica) Flower ... Triolein, Palmitoyl Tripeptide-5, Palmitic Acid, Polygonatum Officinale Rhizome/Root Extract, Arnica Montana (Arnica) Flower ...
... triolein was greater than that of unchlorinated triolein. Water- soluble chlorination products were readily absorbed, were not ...
Triolein, Cetyl Alcohol, Hydroxymethoxyphenyl Decanone, Tocopherol, BHT, Alpha-Isomethyl Ionone. ...
At 5% intake, triolein, tripalmitin and tristearin had similar effects on Mg absorption and resulted in higher absorption of Mg ... The Mg content of the femur was highest in the groups fed 5% or 25%triolein and lowest in the group fed 25% tripalmitin. ..In ...
Triolein. CAT#: 412695 CAS#: 122-32-7 Triolein, also known as Triolein (18:1 TG), Glycerol trioleate, Glycerol triolein, Oleic ...
  • Triolein is a symmetrical triglyceride derived from glycerol and three units of the unsaturated fatty acid oleic acid. (wikipedia.org)
  • Glycerol trioleate also is known as triolein, is a monoacid triglyceride. (lesielle.com)
  • Triolein is also known as glyceryl trioleate and is one of the two components of Lorenzo's oil. (wikipedia.org)
  • Chylomicrons and lipid emulsions were labeled with [ 3 H]triolein, injected into mice, and appearance in plasma of [ 3 H]oleic acid was estimated, either through a steady-state approach or by compartmental modeling. (diabetesjournals.org)
  • Absorption of the chlorinated compounds was greatly reduced compared to the parent compounds and tissue deposition was generally greatly reduced, although deposition of chlorinated oleic acid in the heart was similar to that of oleic acid and deposition of chlorinated triolein was greater than that of unchlorinated triolein. (inchem.org)
  • The oxidation of triolein is according to the formula: C 57H 104O 6 + 80 O 2 → 57 CO 2 + 52 H 2O This gives a respiratory quotient of 57 / 80 {\displaystyle 57/80} or 0.7125. (wikipedia.org)
  • However, data from indirect calorimetry and oxidation of [1- 14 C]-triolein to 14 CO 2 showed that addition of 5.4% RS to the diet significantly increased fat oxidation. (biomedcentral.com)
  • In fact, postprandial oxidation of [1- 14 C]-triolein was 23% greater with the 5.4% RS meal than the 0% meal (p = 0.0062). (biomedcentral.com)
  • So far, biokinetic studies have been performed on the following radiopharmaceuticals and dosimetric models been produced: Tc-99m MIBI, Tc-99m octreotide, C-14 urea, C-14 triolein, C-14 glucose, C-14 glycocholic acid, I-123 ioflupane and F-18 choline. (lu.se)
  • This project aims to lay the groundwork for kinetic studies of the catalytic conversion of pure triolein (a model compound of the extracted lipid feed) in dodecane to optimize the catalytic process through which algae oil is converted to fuels. (aiche.org)
  • Triolein works in tandem with squalane and glycerine (below), to maintain the skin barrier, increase moisturization and reduce Trans Epidermal Water Loss (TEWL). (mccabespharmacy.com)
  • Our results show that uptake of water in the triolein phase can occur and this can be affected by the presence of lipolytic enzymes. (lu.se)
  • Experimental studies of the biokinetics of 111In-DTPA-D-Phe1-octreotide, 99mTc-MIBI , 14C-triolein, and 14C-urea, and development of dosimetric models. (lu.se)
  • Triolein represents 4-30% of olive oil. (wikipedia.org)
  • Hamsters were catheterized as described above and received an oral gavage of 3 μCi [9,10-3H(N)]triolein mixed with 200 μL olive oil. (medscape.com)
  • Biodiesel is produced through a catalytic transesterification of triacylglycerides (e.g., triolein) with alcohols (e.g., methanol). (chemistryviews.org)
  • This project aims to lay the groundwork for kinetic studies of the catalytic conversion of pure triolein (a model compound of the extracted lipid feed) in dodecane to optimize the catalytic process through which algae oil is converted to fuels. (aiche.org)
  • It was found that in the case of gastric lipase the rates of all three steps of triolein hydrolysis are similar, whereas. (karger.com)
  • Activity can be demonstrated turbidimetrically in an emulsion of triolein and sodium deoxycholate together with porcine pancreatic lipase. (leebio.com)
  • Estimation of assimilation of simultaneously ingested 14C-triolein and 3H-oleic acid as a test of pancreatic digestive function. (nih.gov)
  • Proven to deliver instant and long term moisturization, Triolein works in tandem with the cleanser's glycerine (above), to maintain the skin barrier, increase moisturization and reduce TEWL. (selflessbyhyram.com)
  • Triolein increases moisture levels and also acts as a powerful defense against water loss. (superzero.com)
  • Triolein works in tandem with squalane and glycerine (below), to maintain the skin barrier, increase moisturization and reduce Trans Epidermal Water Loss (TEWL). (selflessbyhyram.com)
  • Information in this record refers to the use of (1-14C)-triolein as a diagnostic agent. (nih.gov)
  • The oxidation of triolein is according to the formula: C 57H 104O 6 + 80 O 2 → 57 CO 2 + 52 H 2O This gives a respiratory quotient of 57 / 80 {\displaystyle 57/80} or 0.7125. (wikipedia.org)