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... Home - The Cancer Genome Atlas - Cancer Genome - TCGA. About Cancer Genomics. What is Cancer Genomics. Cancers Selected for Study. TCGA in Action. News and Events. TCGA In The News. Multimedia Library. About TCGA. Program Overview. Compassion and Curiosity. William Kim, M.D., is motivated by two things: compassion and curiosity. Learn More. TCGA study of genetic drivers of melanoma. A comprehensive analysis of the genome of cutaneous melanoma has provided new insights into the roles of frequently mutated cancer genes and other genomic alterations that drive the development of this disease. Learn More. Cancers Selected for Study. The Cancer Genome Atlas researchers are mapping the genetic changes in 20 cancers. Find out which cancers have been selected for study, the criteria for selection and the scientific questions being asked about each cancer. Learn More. Program Overview. Explore how The Cancer Genome Atlas works, the components of the TCGA Research Network and TCGA's place in the cancer genomics fie...
*  Celline expression of FOSL2 in TIME - HPA004817 - The Human Protein Atlas
... Class Enzymes CD markers Blood group antigen proteins Nuclear receptors Transporters Ribosomal proteins G-protein coupled receptors Voltage-gated ion channels Predicted membrane proteins Predicted secreted proteins Plasma proteins Transcription factors Mitochondrial proteins RNA polymerase related proteins RAS pathway related proteins Citric acid cycle related proteins Cytoskeleton related proteins Cancer-related genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Potential drug targets Mapped to UniProt SWISS-PROT Protein evidence Kim et al 2014 Protein evidence Ezkurdia et al 2014. Tissue Any Adrenal gland Appendix Bone marrow Breast Bronchus Cerebellum Cerebral cortex Cervix, uterine Colon Duodenum Endometrium 1 Endometrium 2 Epididymis Esophagus Fallopian tube Gallbladder Heart muscle Hippocampus Kidney Lateral ventricle Liver Lung Lymph node Nasopharynx Oral mucosa Ovary Pancreas Parathyroid gland Placenta Prostate Rectum Salivary gland Seminal vesicle Skeleta...
*  Homemade Serenity: Why Don't You Make Valentines Day Votives?
... Homemade Serenity: Why Don't You Make Valentines Day Votives. Why Don't You Make Valentines Day Votives. I LOVE Valentine's Day. Liquid starch is just that. We took white craft tissue paper and tore it into small squares. He then painted a small amount of liquid starch right over the top of the tissue paper. Simple Mama. Simple Mama. : Reply Delete. Reply Delete. Reply Delete. Simple Mama. Reply Delete. Reply Delete. Simple Mama. February 13, 2011 at 1:13 PM Thanks. : Reply Delete. Reply Delete. Reply Delete. ~ May Reply Delete. January 5, 2012 at 5:03 PM I just discovered your blog as I was adding to a list of Valentine's Day craft ideas for kids. I even added this votive idea to this list: Valentine's Day Craft Ideas for Kids Reply Delete. Reply Delete. January 17, 2012 at 2:05 PM Put out the email at school today for my co-teachers to start saving glass jars. : just read your blog, they look wonderful : would love ...
*  LASIK Eye Surgery in Ogden UT | Country Hills Eye Center
... LASIK Eye Surgery in Ogden UT. Country Hills Eye Center. 1 888 EYE-CNTR 1 801 399-1149 Complimentary Wi-Fi Country Hills Eye Center is helping Haiti. LASIK. Contact Lenses. Cataract Surgery. ~ CHEC Facebook ~ Patient Portal New Patient Portal. Choose Us for Premier LASIK Surgery in Ogden, UT. Laser procedures have made significant improvements in the treatment of eye disorders, so many patients no longer have to depend on glasses and contact lenses for vision correction. At Country Hills Eye Center, we are pleased to be a part of this ever-evolving industry. Our LASIK eye surgery procedures in Ogden, UT are helping people lead more active and convenient lives. What is LASIK. The surgeon uses a laser to create a flap. What Conditions Can LASIK Treat. Lasik provides the opportunity of clear sight to countless numbers of people unable to live the lives they want due to vision abnormalities. LASIK can treat the following:. The surgeon will apply an anesthetic “eye drop” to ensure a painless process. The vast ...
*  DSpace at IIT Bombay: Browsing DSpace
tensiometry of tissues using Langmuir films PREETHA, A ; ... dspace at iit bombay browsing dspace search dspace advanced search home browse communities collections issue date author title subject sign on to receive email updates my dspace authorized users edit profile help about dspace dspace at iit bombay browsing by author preetha a jump to a b c d e f g h i j k l m n o p q r s t u v w x y z or enter first few letters sort by issue date submit date title in order ascending descending results page authors record all showing results to of issue date title author s comparison of paclitaxel penetration in normal and cancerous cervical model monolayer membranes preetha a huilgol ..., A&starts_with=Y
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different types of tissues with high spatial resolution. Because...[show_abstracts]=0&tx_sevenpack_pi1[show_keywords]=0&tx_sevenpack_pi1[export]=bibtex
*  South Carolina State University
... South Carolina State University. Skip to Main Content. South Carolina State University A-Z Index. Virtual Tour. Search Search Input:. About SC State. Give to SC State. Home SC State University gives you the facts on the H1N1 flu and tips to stay healthy. SC State University gives you the facts on the H1N1 flu and tips to stay healthy. 2009 H1N1, referred to as swine flu early on, is a new influenza virus causing illness in people. This new virus was first detected in people in the United States in April, 2009. This virus is spreading from person-to-person worldwide, probably in much the same way that regular seasonal influenza viruses spread. Symptoms of H1N1 The symptoms of novel H1N1 flu virus in people are similar to the symptoms of seasonal flu and include fever, cough, sore throat, runny or stuffy nose, body aches, headache, chills, and fatigue. A significant number of people who have been infected with novel H1N1 flu virus also have reported diarrhea and vomiting. People at higher risk of serious co...
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... QSpace at Queen's University: Browsing QSpace. Queen's University - Utility Bar. Text Only Version. Skip to Navigation. Library Services for Students with Disabilities. Web Standards and Accessibility Guide. Queen's University. QSpace. Queen's University. Search QSpace:. Home. About QSpace. Search QSpace. Browse. How to Submit. My Account. Help. Feedback. QSpace at Queen's University. Browsing by Subject Obesity. Jump to: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z. or enter first few letters:. . Sort by: issue date submit date title In order: Ascending Descending Results/Page 5 10 15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 90 95 100 Authors/Record: All 1 5 10 15 20 25 30 35 40 45 50. Showing results 1 to 6 of 6. Preview Issue Date Title Author s. 6-Jun-2013. THE ACUTE IMPACT OF A SINGLE DOSE OF RESVERATROL ON INSULIN SENSITIVITY, WHOLE BODY FAT OXIDATION, AND INTRACELLULAR SIGNALING IN SKELETAL MUSCLE AND ADIPOSE TISSUE IN OVERWEIGHT AND OBESE MEN. WILLIAMS, CAMERON. 3-Oct-2015. ADDITION OF...

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(1/22) Polyploidy and cancer; the desoxypentosenucleic acid content of nuclei of normal, precancerous, and neoplastic rat tissues.

The average desoxypentosenucleic acid content of individual nuclei was determined for various normal and tumor tissues, and for livers showing precancerous changes, in the rat. With certain exceptions attributable to polyploidy, the values were practically indistinguishable from each other and from values reported for cell nuclei of other mammals. The amount of this nucleic acid in diploid cells of the rat appears to be a constant, nearly equal to 6 x 10(-6) micrograms. Findings of increased concentrations of this nucleic acid in tissues showing preneoplastic or neoplastic changes therefore confirm histological observations of increased cellularity and polyploidy in such tissues.  (+info)

(2/22) Tissue culture studies. VI. The effect of medium constituents on nucleic acids and uptake of p32.

The effect of horse serum alone, and of embryo extract alone, was compared with that of "complete medium" on the content and synthesis of ribo- and desoxyribonucleic acids and uptake of tracer P(32) by chick heart cultures in vitro. The factors mentioned are influenced by embryo extract in a manner similar to the effect in complete medium. Horse serum produced little synthesis of nucleic acids or uptake of tracer, giving only slightly more effect than Tyrode's solution alone. Cutting the tissue into smaller pieces caused considerably greater synthetic effects, and retarded necrosis of the implant.  (+info)

(3/22) Hereditary osteopetrosis of the rabbit. IV. Pathologic observations; general features.

The results of postmortem examination of cases of hereditary osteopetrosis of the rabbit together with histologic observations on organs and tissues other than the skeleton have been described. The principal findings were, first, those associated with the characteristic progressive anemia of the disease, such as extramedullary foci of hemopoietic tissue, lymphoid hyperplasia, and the occurrence of hemosiderin in the liver, spleen, and lymph nodes. There was a widespread tissue distribution of intense phosphatase staining and of fine calcium deposition, as would be expected in the circumstances of the profound skeletal abnormality (3). In advanced cases with established growth retardation, malnutrition, and deterioration, the tissues generally showed a decreased glycogen content. The large amount of parathyroid tissue found in both early and late cases suggested a state of hyperparathyroidism. Low serum calcium, high serum phosphorus and phosphatase levels (2), and a predominately osteoblastic reaction (3) were suggestive of hypoparathyroidism. The possibility that an involvement of the parathyroid glands was a basic or primary condition of the disease is discussed. Evidence of a disturbance of other endocrine glands was shown by the predominately acidophilic staining reaction of the colloid of the thyroid, an enlargement of the adrenals in which both cortex and medulla participated, and the tendency toward a basophilia of the anterior lobe of the pituitary. It was pointed out that before an explanation of the part played by the parathyroid glands in this disease could be made, other data, including particularly embryological studies, must be available. Similarly, an interpretation of other endocrine gland changes must await additional information.  (+info)

(4/22) A method for rapid measurement of intrarenal and other tissue pressures.

A rapid method for measuring tissue pressures has been designed. A pressure of 250 mm. Hg is imposed on a manometer. Then the system is allowed to discharge into a needle cannula inserted in the tissue. The manometer forces out fluid (about 10 until the pressure within it is the same as that within the tissue. Records of the pressure changes are made. Each observation takes about a minute. The method gives results that are closely comparable with other reports of tissue pressures. With this method, the pressure in the following organs of dogs was found to be: kidney, 26 mm. Hg, cerebral cortex, 0 to 5 mm., muscle, 1 to 10 mm., spleen, S to 16 mm., subcutaneous tissue, 0 to 3 mm., and liver -2 to 14 mm. The reliability of the method was tested on the kidneys of decerebrate dogs. Measurements were found to be the same within narrow limits over a period of an hour; they were the same when taken simultaneously in different regions of the same kidney or in opposite kidneys. They were independent of the volume of fluid forced into the tissue. Similar pressures were observed with 1 or 5 or 10 holes bored in the shaft of the cannulating needle. The intrarenal pressure was also measured by inserting a needle cannula into the tissue and then allowing the pressure to reach equilibrium passively with a manometer. This method gave similar results. The intrarenal pressure has now found to be the same when measured by three different technics.  (+info)

(5/22) Conversion of plasma protein to tissue protein without evidence of protein breakdown; results of giving plasma protein labeled with carbon 14 parenterally to dogs.

Labeled plasma proteins obtained from donor dogs, previously fed epsilon-C(14)-dl-lysine, have been given intravenously to recipient dogs. The disappearance of labeled globulin from the plasma at a rate considerably faster than albumin has been confirmed. Evidence suggesting that the mass of protein in solution in the extravascular, extracellular fluid is approximately equal to the plasma proteins in circulation has been derived from a study of the dilution of labeled plasma protein by repeated injections of non-labeled plasma protein. In a period of 7 days the transfer of C(14) from plasma to tissue proteins amounted to between 30 and 40 per cent of the activity in the labeled plasma protein injected intravenously. The conversion was accompanied by a very small loss of activity in the urine and expired air and the activity remained in the lysine residue of the liver and probably of other tissues. The data presented favor the view that plasma proteins are utilized in the body economy after partial catabolism within the cell area and provide no evidence of complete breakdown to the amino acid level.  (+info)

(6/22) Experiments on the role of potassium in the blocking of neuromuscular transmission by curare and other drugs.

1. Experiments with perfused frog muscles and with isolated frog muscles immersed in Ringer's solution have failed to show any effect of curare in liberating potassium from muscle tissue. This makes it difficult to suppose that the paralytic effect of curare can be attributed to cation exchange between curare and K whereby a labile potassium compound needed for stimulation is removed from the neuromuscular junction. 2. Similar negative results were obtained with dihydro-beta-erythroidine and myanesin. 3. A small liberation of K from perfused muscle does result from treatment with acetylcholine. This is probably due to the contracture of the muscle since the effect is largely eliminated by previous treatment of the muscle with curare. The amount of potassium lost in this way from perfused muscles is too small to detect when muscles are analyzed after immersion in Ringer's solution with and without acetylcholine. It is concluded that there is no significant cation exchange between acetylcholine and K in muscle, but only a small loss of K due to the contracture produced by the acetylcholine.  (+info)

(7/22) Studies on isolated cell components.

1. The addition of heparin to rat liver, kidney, or brain nuclei has been found to bring about the release of a gel. Chemical analysis and histochemical studies on whole homogenates and isolated nuclei demonstrated that the material released by heparin contained desoxyribonucleic acid (DNA) and protein. The action of heparin on nuclei is interpreted as the result of a combination with the basic proteins of the nucleus with a consequent displacement of DNA. 2. The addition of heparin to a finely divided dilute liver homogenate prepared in a phosphate-sucrose solution at pH 7.1 brings about a marked increase in viscosity which reaches a maximum in 6 to 8 minutes at 23 degrees and then declines. 3. The concentration threshold for the viscosity effect was 0.1 mg. per 100 mg. fresh rat liver, with further increases in viscosity at higher heparin concentrations. Over a period of several hours a marked decrease in response to heparin was observed in homogenates stored at 0 degrees . 4. Fractionation of the homogenate demonstrated that the viscosity increase was due to the presence of the nuclei alone, other components showing no effect. Microscopic observation showed that the increase in viscosity was associated with the appearance of a clear gel around nuclei treated with heparin. 5. Heparin brought about the release of DNA from the nuclei of incubated rat liver, kidney, and brain homogenates. In some instances over half the DNA is found in the supernatant after high speed centrifugation (20 minutes, 21,000 x g). 6. No correlation was found between anticoagulant activity of heparin preparations and their effectiveness in causing an increase in the viscosity of liver homogenates. Desulfated heparin produced none of the results described here for heparin.  (+info)

(8/22) The effect of podophyllotoxin on tissue metabolism and enzyme systems.

Podophyllotoxin, 10(-3) (M), inhibits the respiration in vitro of rat lymph nodes, thymus, kidney, tumor, spleen, liver, brain, testis, and chicken embryo. Lymph node and spleen respiration are most sensitive, and the degree of inhibition increases with time. The injection of podophyllotoxin into tumor-bearing mice (20 mg. per kg.) causes a dramatic reduction in the respiration of tumor slices. Within 6 hours, the respiration approaches zero. Inhibition is evident 2 hours after injection of the drug. Spleen respiration is reduced 50 per cent within 6 hours. Kidney and liver respirations remain within normal limits. Marked reductions in the respiration of spleen, lymph nodes, and thymus glands of normal rats are produced by the injection of 15 mg. per kg. Thymus gland is the most sensitive of these three tissues, and its respiration is reduced 66 per cent 24 hours after injection of the drug. The injection of 0.8 microgram podophyllotoxin into the yolk sac of chicken eggs bearing 5 day embryos has no effect on the respiration of the embryo within 8 hours, although this is a sufficiently toxic dose to kill 80 per cent of the embryos (within 24 hours). Kidney respiration in the presence of acetate, glucose, alanine, and glutamate is inhibited to approximately the same degree as in the absence of added substrate. Succinate and pyruvate oxidation by rat kidney slices appear to be less sensitive. Oxidation of acetate and butyrate by rabbit kidney homogenate is more sensitive to podophyllotoxin than oxidation by rabbit kidney homogenate without added substrate. Glucose oxidation by this preparation is not inhibited by 10(-3)M podophyllotoxin. The anaerobic glycolysis of chicken embryo, rat brain, and rat testis is stimulated by 10(-5) and 10(-6)M podophyllotoxin, and is inhibited by 10(-3)M. The following enzymes are not inhibited by 10(-3)M podophyllotoxin: succinoxidase from pigeon breast muscle, choline, xanthine and tyrosine oxidase from rat liver homogenate, and leucine oxidase from Proteus vulgaris; alkaline and acid phosphatase from dog serum; adenosine triphosphatase from rat liver; choline esterase from rat brain homogenate; ribonucleodepolymerase from spleen mince and thymonucleodepolymerase from dog serum. High concentrations of podophyllotoxin do not influence the viscosity and degree of polymerization of thymonucleic acid.  (+info)

how long before your tissues start dying when blood stop flowing to your arm?

when you sit in a bad position for too long, and blood stop circulating into your arm and you get a numb arm. how long before your tissues and muscles in your arm start dying? im getting this right now and i have a numb arm and i wonder if any muscles in my arm have died.

What, you mean it's asleep?

Let's say you're sitting in a chair and your butt starts to feel tingly. That's because your body weight is cutting off some blood from your artery.

It's no big deal, really. Cells die all the time. What happens first is the nerves shut down, then the rest starts to go.. but it's really nothing to worry about if it's minor. I mean, unless it's turning blue or black anything- who cares?

Basically- you have nothing to worry about. Your arm willl start feeling again in no time.

I run a tissue box factory and i need help finding good tissues?

I was thinking of putting pepper in my tissues that  i sell. i also thought of putting grains in it or just plain sand paper. please give me some ideas of what to put in my tissues?

Maybe cat dander or hamster hair... I'm sure it would work wonders!! Maybe you could even collect some pollen from the pretty spring flowers that are blooming and throw that in there.

What are ALL the ORGANS and TISSUES involved in the respiratory system?

ALL the organs and the types of tissues involved ONLY.
I cant seem to find all the organs.. Thank you

nose-nasal cavity-pharynx -larynx-trachea-bronchi-lung-bronchus-

Can lack of exercise cause bones and tissues to be painful?

I'm 18 years old and these few days my bones and some of the tissues in my arms and legs are painful usually at night. I'm on vacation from school this past 2 weeks. I'm practically not doing anything compared to my active lifestyle when there are classes.
I'm asking if LACK of exercise can cause bones and surrounding tissues to be painful, not if exercise causes it.

Exercise strengthens the bones. It causes the body to strengthen the insides of the bones, by increasing the webbing connections within them. Exercise definitely increases bone density. The body must have regular weight-bearing exercise, such as walking. When this occurs, more minerals are laid down in the bones, to strengthen them—especially where you need it the most: the bones of the legs, hips, and spine. Conversely, a lack of exercise accelerates the loss of bone mass. It is believed that lack of activity in old age is a factor in the increased levels of bone loss in those years.

Daily exercise outdoors provides vitamin D and stimulates osteoblastic cells. Exercise increases muscle tone, strengthens muscles, prevents disuse atrophy and further demineralization of the bones

NASA research experts say the best activity for maintaining bone mass is gravitational: walking or jogging. When you are not pushing against gravity very much (because you are sitting in a chair or lying in bed), you are tending to lose bony material. Try to walk at least 20 minutes a day out-of-doors.

"Strain changes" are important in building and maintaining bone mass. How often you do it is more important than the intensity when it is done. Try to maintain the bounce of earlier years: keep that spring in your step; put a little strain on your body and muscles every so often. Do this more moderately as you age, but keep it up. 

Bed rest tends to cause a negative calcium balance. Bones placed in plaster casts develop localized osteoporosis, regardless of the diet, hormonal balance, etc. It is called "disuse osteoporosis." Exercise is vital to healthy bones

Go to the site below:

It has been documented that the pain in the bones and tissues might be due to your ongoing growing process. It might also be caused by calcium deficiency.    Take calcium supplements to strengthen the bones.  You also need Vid for cacium to be absorbed properly.   

How can we know if there are still tissues left in the uterus after a miscarriage?

I was 5 wks preggy then had a miscarriage due to blighted ovum. The doc advised to let it all out naturally. I had a bleeding for about 3 weeks with regular check up. After the bleeding will stop, how can I be sure if all tissues had been expelled? Are there symptoms that we can feel?

Usually the doctor follows up and has you go for new bloodwork.  In that way he/she can evaluate you hcG ( a pregnancy hormone)levels to determine if u successfully miscarried. Symptoms of pregnancy will also start to dwindle slowly.  I cant say that there are symptoms to look for as far as being sure that u have expelled the ovum.

how are each of the tissues types important to you?

Suppose you are an athletic trainer, how are each of the tissues types important to you? Your explanation should mention each of the 4 tissues, but have a concentration on connective tissue.

the 4 main types are epithelial tissues, connective tissues, muscle tissues, and nervous tissues...

EPITHELIA: layers of cells that cover organ surfaces such as the surface of the skin, the airways, the reproductive tract, and the inner lining of the digestive tract.... help in secretion and absorbtion

CONNECTIVE:  Connective tissue holds other tissues together such as in the formation of organs, and has the ability to stretch and contract passively. Bone and blood are examples of specialized connective tissues.

MUSCLE:   Muscle tissue functions to produce force and cause motion, either locomotion or movement within internal organs. Muscle tissue is separated into three distinct categories: visceral or smooth muscle, which is found in the inner linings of organs; skeletal muscle, in which is found attached to bone providing for gross movement; and cardiac muscle which is found in the heart, allowing it to contract and pump blood throughout an organism.

NERVOUS:  made up of the Central Nervous System and the Peripheral Nervous System. Comprised of neural and nervous tissue, the CNS and PNS transmit signals from the brain to the body parts (muscles, glands, sense organs) to activate a response.

 Connective tissue's function is primarily to support, anchor, and connect various parts of the body.  It is important for an athletic trainer because that's where most injuries happen... tendons, ligaments, cartilage....

The body has 4 types of tissue that make up the entire body. These tissues specialize, work together, and make?

The body has 4 types of tissue that make up the entire body. These tissues specialize, work together, and make many different processes happen. Describe the differences between these tissues, as well as describe the characteristics that allow each type of tissue to perform that specific function.


Can chemotherapy damage tissues so that they are unable to be used for organ transplants?

I'm just curious as to whether chemotherapy or other treatments for potentially terminal illnesses, like certain cancers, can damage or effect tissues in a way that makes them unfit for transplant.