A methylsulfonyl analog of CHLORAMPHENICOL. It is an antibiotic and immunosuppressive agent.
An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea.
An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)
Acute, localized autoinoculable infectious disease usually acquired through sexual contact. Caused by HAEMOPHILUS DUCREYI, it occurs endemically almost worldwide, especially in tropical and subtropical countries and more commonly in seaports and urban areas than in rural areas.
A species of gram-negative, aerobic bacteria primarily found in purulent venereal discharges. It is the causative agent of GONORRHEA.
Group of diseases mediated by the deposition of large soluble complexes of antigen and antibody with resultant damage to tissue. Besides SERUM SICKNESS and the ARTHUS REACTION, evidence supports a pathogenic role for immune complexes in many other IMMUNE SYSTEM DISEASES including GLOMERULONEPHRITIS, systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC) and POLYARTERITIS NODOSA.
Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879.
A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.
Substances that reduce the growth or reproduction of BACTERIA.

A comparison of florfenicol and tilmicosin for the treatment of undifferentiated fever in feedlot calves in western Canada. (1/106)

A field trial was performed under commercial feedlot conditions in western Canada to compare the efficacy of florfenicol and tilmicosin for the treatment of undifferentiated fever (UF) in calves that received metaphylactic tilmicosin upon arrival at the feedlot. One thousand and eighty recently weaned, auction market derived, crossbred beef calves suffering from UF were allocated to one of 2 experimental groups as follows: florfenicol, which was intramuscular (i.m.) florfenicol administered at the rate of 20 mg/kg body weight (BW) at the time of allocation (Day 0) and again 48 h later, or tilmicosin, which was subcutaneous (s.c.) tilmicosin administered once at the rate of 10 mg/kg BW on day 0. Five hundred and forty-four animals were allocated to the florfenicol group and 536 animals were allocated to the tilmicosin group. The chronicity, wastage, overall mortality, and bovine respiratory disease (BRD) mortality rates were significantly (P < 0.05) lower in the florfenicol group than in the tilmicosin group. There were no significant (P > or = 0.05) differences in first UF relapse, second UF relapse, hemophilosis mortality, or miscellaneous mortality rates between the florfenicol and tilmicosin groups. Average daily gain (ADG) from arrival at the feedlot to the time of implanting and ADG from allocation to the time of implanting were significantly (P < 0.05) lower in the florfenicol group as compared with the tilmicosin group. There were no significant (P > or = 0.05) differences in arrival weight, allocation weight, implanting weight, or ADG from arrival to allocation between the experimental groups. In the economic analysis, there was an advantage of $18.83 CDN per animal in the florfenicol group. The results of this study indicate that florfenicol is superior to tilmicosin for the treatment of UF because of lower chronicity, wastage, overall mortality, and BRD mortality rates. However, interpretation of these observations must take into consideration the fact that these calves received meta-phylactic tilmicosin upon arrival at the feedlot, which is a standard, cost-effective, management procedure utilized by feedlots in western Canada.  (+info)

Detection of multidrug-resistant Salmonella enterica serotype typhimurium DT104 based on a gene which confers cross-resistance to florfenicol and chloramphenicol. (2/106)

Salmonella enterica serotype typhimurium (S. typhimurium) DT104 (DT104) first emerged as a major pathogen in Europe and is characterized by its pentadrug-resistant pattern. It has also been associated with outbreaks in the United States. The organism typically carries resistance to ampicillin, chloramphenicol, streptomycin, sulfonamides, and tetracycline. The mechanism of chloramphenicol resistance in DT104 was determined by producing antibiotic-resistant Escherichia coli host strain clones from DT104 DNA. DNA from chloramphenicol-resistant clones was sequenced, and probes specific for the genes floS. typhimurium (floSt), int, invA, and spvC were produced for colony blot hybridizations. One hundred nine Salmonella isolates, including 44 multidrug-resistant DT104 isolates, were tested to evaluate the specificities of the probes. The gene floSt, reported in this study, confers chloramphenicol and florfenicol resistance on S. typhimurium DT104. Florfenicol resistance is unique to S. typhimurium DT104 and multidrug-resistant S. typhimurium isolates with the same drug resistance profile among all isolates evaluated. Of 44 DT104 isolates tested, 98% were detected based on phenotypic florfenicol resistance and 100% had the floSt-positive genotype. Resistances to florfenicol and chloramphenicol are conferred by the gene floSt, described in this paper. Presumptive identification of S. typhimurium DT104 can be made rapidly based on the presence of the floSt gene or its resulting phenotype.  (+info)

Effects of thiamphenicol and chloramphenicol in inhibiting Neisseria gonorrhoeae isolates. (3/106)

Thiamphenicol was compared with penicillin, tetracycline, and chloramphenicol for its ability to inhibit 530 isolates of Neisseria gonorrhoeae, including 13 penicillinase-producing isolates. Thiamphenicol proved to be as active as chloramphenicol in inhibiting all of the isolates.  (+info)

Evolution of chloramphenicol resistance, with emergence of cross-resistance to florfenicol, in bovine Salmonella Typhimurium strains implicates definitive phage type (DT) 104. (4/106)

The prevalence of resistance to florfenicol, a phenicol drug newly introduced in veterinary therapy, was determined in 86 chloramphenicol-resistant Salmonella Typhimurium isolates from cattle collected during 1985-1995. All were highly resistant to chloramphenicol (MICs > or = 128 mg/L) and 38 were simultaneously resistant to florfenicol (MICs >16 mg/L) and to beta-lactam agents, spectinomycin, streptomycin, sulphonamides and tetracyclines. The isolates susceptible to florfenicol harboured the chloramphenicol acetyl transferase gene, cat of type I. All the florfenicol-resistant isolates harboured the floR resistance gene and the characteristic multiple resistance genetic locus, previously characterised in a S. Typhimurium DT104 strain and identified by a multiplex PCR. Plasmid profiles and ribotype patterns were determined for all the isolates. The florfenicol-resistant isolates were grouped into the same ribotyping pattern and presented similar plasmid profiles, whereas the florfenicol-susceptible isolates showed a wider genetic diversity that is usual for S. Typhimurium. Thus, the florfenicol-resistant isolates could represent a clonal cluster, closely related to, if not of DT104 phage type, which appeared in 1989 and is now predominant within chloramphenicol-resistant S. Typhimurium. The multiplex PCR provided a useful tool to survey further evolution of multiresistant S. Typhimurium strains.  (+info)

Detection of florfenicol resistance genes in Escherichia coli isolated from sick chickens. (5/106)

Florfenicol is an antibiotic approved for veterinary use in cattle in the United States in 1996. Although this drug is not used in poultry, we have detected resistance to florfenicol in clinical isolates of avian Escherichia coli. Molecular typing demonstrated that the florfenicol resistance gene, flo, was independently acquired and is plasmid encoded.  (+info)

Occurrence of a Salmonella enterica serovar typhimurium DT104-like antibiotic resistance gene cluster including the floR gene in S. enterica serovar agona. (6/106)

Recently a chromosomal locus possibly specific for Salmonella enterica serovar Typhimurium DT104 has been reported that contains a multiple antibiotic resistance gene cluster. Evidence is provided that Salmonella enterica serovar Agona strains isolated from poultry harbor a similar gene cluster including the newly described floR gene, conferring cross-resistance to chloramphenicol and florfenicol.  (+info)

Antibacterial effect of chloramphenicol, thiamphenicol and florfenicol against aquatic animal bacteria. (7/106)

The minimum inhibitory concentration (MIC) was measured to evaluate the antibacterial activities of chloramphenicol (CP), thiamphenicol (TP) and florfenicol (FFC) against the aquatic bacterial isolates from soft-shell turtles, fish and shellfish. Amoxicillin (AMPC), oxytetracycline (OTC) and oxolinic acid (OA) were included to compare with above protein synthesis inhibitors. The results showed that the order of MIC range of the isolates from soft-shell turtles for tested drugs was OA>FFC, CP>TP> AMPC, OTC. The percentage of the resistant strains indicated that OA was the lowest (7.14%) and OTC was the highest (85.07%). The order of antibacterial activity against the isolates from fish was OA>FFC>CP>AMPC>OTC>TP. The percentage of the resistant strains revealed that OA (13.64%) and OTC (80.91%) were the lowest and the highest, respectively. For the isolates from shellfish, the order of antimicrobial activity was OA>CP, FFC>AMPC, OTC, TP. TP showed the greatest percentage of the resistant strains (58.7%), but that of OA was the lowest (4.35%). The most common resistant patterns of the isolates from turtles, fish and shellfish were AMPC-OTC, CP-TP-AMPC-OTC, and FFC-CP-TP-AMPC-OTC, respectively. There were partially-complete resistance of the resistant isolates among CP, TP and FFC. The findings indicated that previous treatment might affect the choice of drug to use for aquatic bacterial diseases.  (+info)

Thiamphenicol in the treatment of chancroid. A study of 1,128 cases. (8/106)

Thiamphenicol, an aminic derivate of hydrocarbilsulfonil propandiol, was used for the treatment of 1,171 chancroid bearing patients. Each patient was medicated with 5.0 g of granulated thiamphenicol, orally, in a single dose, and was reevaluated 3, 7 and 10 days after the treatment. Ten patients (0.89%) did not respond to the proposed treatment. 133 patients presented healed ulcers after 3 days of treatment, 976 patients healed chancres on the seventh day after the treatment, and 39 patients took 10 days to present healed chancres. The results of this study indicate that the rate of patients that were cured, the low incidence of side effects, and the practicality of administration make of thiamphenicol an excellent choice for the treatment of chancroid.  (+info)

Thiamphenicol is an antibiotic that belongs to the class of medications called amphenicols. It works by preventing the growth of bacteria. Thiamphenicol is used to treat various infections caused by bacteria. This medication may also be used to prevent bacterial endocarditis (inflammation of the lining of the heart and valves) in people having certain dental or surgical procedures.

Please note that this definition is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. If you have any questions about your medication, always consult with your healthcare provider.

Spectinomycin is an antibiotic that belongs to the aminoglycoside family. It works by binding to the 30S subunit of the bacterial ribosome, thereby inhibiting protein synthesis and leading to bacterial cell death. Spectinomycin is primarily used to treat infections caused by susceptible strains of Gram-negative and Gram-positive bacteria, including gonorrhea, penicillin-resistant streptococci, and some anaerobes. It is administered parenterally (usually intramuscularly) and has a relatively narrow spectrum of activity compared to other aminoglycosides. Spectinomycin is not commonly used in many countries due to the availability of alternative antibiotics with broader spectra and fewer side effects.

Chloramphenicol is an antibiotic medication that is used to treat a variety of bacterial infections. It works by inhibiting the ability of bacteria to synthesize proteins, which essential for their growth and survival. This helps to stop the spread of the infection and allows the body's immune system to clear the bacteria from the body.

Chloramphenicol is a broad-spectrum antibiotic, which means that it is effective against many different types of bacteria. It is often used to treat serious infections that have not responded to other antibiotics. However, because of its potential for serious side effects, including bone marrow suppression and gray baby syndrome, chloramphenicol is usually reserved for use in cases where other antibiotics are not effective or are contraindicated.

Chloramphenicol can be given by mouth, injection, or applied directly to the skin in the form of an ointment or cream. It is important to take or use chloramphenicol exactly as directed by a healthcare provider, and to complete the full course of treatment even if symptoms improve before all of the medication has been taken. This helps to ensure that the infection is fully treated and reduces the risk of antibiotic resistance.

Chancroid is a sexually transmitted infection caused by the bacterium Haemophilus ducreyi. It is characterized by the presence of painful, ulcerating lesions on the genitals. The infection is more common in men than women and is often found in areas with poor sanitation and hygiene. Chancroid is a major cause of genital ulcers in many parts of the world, but it is relatively rare in developed countries.

The primary symptom of chancroid is the development of one or more painful, soft, and easily bleeding ulcers on the genitals within a few days to two weeks after exposure. The ulcers may be accompanied by swelling of the lymph nodes in the groin. In some cases, the ulcers may become covered with a gray or yellowish-white exudate.

Chancroid is diagnosed through the examination of a sample taken from the ulcer. The sample is examined under a microscope for the presence of H. ducreyi bacteria. If the bacteria are not visible, a culture can be grown to confirm the diagnosis.

Treatment for chancroid typically involves the use of antibiotics such as azithromycin or ceftriaxone. It is important to receive treatment promptly to prevent the spread of the infection and to avoid complications such as scarring, difficulty urinating, and infertility.

Prevention measures for chancroid include practicing safe sex, limiting the number of sexual partners, and getting regular STI screenings. If you suspect that you may have chancroid or any other STI, it is important to seek medical attention promptly.

Neisseria gonorrhoeae is a species of gram-negative, aerobic diplococcus that is the etiologic agent of gonorrhea, a sexually transmitted infection. It is commonly found in the mucous membranes of the reproductive tract, including the cervix, urethra, and rectum, as well as the throat and eyes. The bacterium can cause a range of symptoms, including discharge, burning during urination, and, in women, abnormal menstrual bleeding. If left untreated, it can lead to more serious complications, such as pelvic inflammatory disease and infertility. It is important to note that N. gonorrhoeae has developed resistance to many antibiotics over time, making treatment more challenging. A culture or nucleic acid amplification test (NAAT) is used for the diagnosis of this infection.

Immune complex diseases are medical conditions that occur when the immune system produces an abnormal response to certain antigens, leading to the formation and deposition of immune complexes in various tissues and organs. These immune complexes consist of antibodies bound to antigens, which can trigger an inflammatory reaction and damage the surrounding tissue.

Immune complex diseases can be classified into two categories: acute and chronic. Acute immune complex diseases include serum sickness and hypersensitivity vasculitis, while chronic immune complex diseases include systemic lupus erythematosus (SLE), rheumatoid arthritis, and membranoproliferative glomerulonephritis.

The symptoms of immune complex diseases depend on the location and extent of tissue damage. They can range from mild to severe and may include fever, joint pain, skin rashes, kidney dysfunction, and neurological problems. Treatment typically involves medications that suppress the immune system and reduce inflammation, such as corticosteroids, immunosuppressants, and anti-inflammatory drugs.

Gonorrhea is a sexually transmitted infection (STI) caused by the bacterium Neisseria gonorrhoeae, also known as "gono" bacteria. It can infect various parts of the body including the genitals, rectum, and throat. The bacteria are typically transmitted through sexual contact with an infected person.

Symptoms may vary but often include abnormal discharge from the genitals or rectum, painful or burning sensations during urination, and in women, vaginal bleeding between periods. However, many people with gonorrhea do not develop symptoms, making it essential to get tested regularly if you are sexually active with multiple partners or have unprotected sex.

If left untreated, gonorrhea can lead to severe complications such as pelvic inflammatory disease (PID) in women and epididymitis in men, which may result in infertility. In rare cases, it can spread to the bloodstream and cause life-threatening conditions like sepsis.

Gonorrhea is curable with appropriate antibiotic treatment; however, drug-resistant strains of the bacteria have emerged, making accurate diagnosis and effective treatment increasingly challenging. Prevention methods include using condoms during sexual activity and practicing safe sex habits.

Penicillin G is a type of antibiotic that belongs to the class of medications called penicillins. It is a natural antibiotic derived from the Penicillium fungus and is commonly used to treat a variety of bacterial infections. Penicillin G is active against many gram-positive bacteria, as well as some gram-negative bacteria.

Penicillin G is available in various forms, including an injectable solution and a powder for reconstitution into a solution. It works by interfering with the ability of bacteria to form a cell wall, which ultimately leads to bacterial death. Penicillin G is often used to treat serious infections that cannot be treated with other antibiotics, such as endocarditis (inflammation of the inner lining of the heart), pneumonia, and meningitis (inflammation of the membranes surrounding the brain and spinal cord).

It's important to note that Penicillin G is not commonly used for topical or oral treatment due to its poor absorption in the gastrointestinal tract and instability in acidic environments. Additionally, as with all antibiotics, Penicillin G should be used under the guidance of a healthcare professional to ensure appropriate use and to reduce the risk of antibiotic resistance.

Anti-bacterial agents, also known as antibiotics, are a type of medication used to treat infections caused by bacteria. These agents work by either killing the bacteria or inhibiting their growth and reproduction. There are several different classes of anti-bacterial agents, including penicillins, cephalosporins, fluoroquinolones, macrolides, and tetracyclines, among others. Each class of antibiotic has a specific mechanism of action and is used to treat certain types of bacterial infections. It's important to note that anti-bacterial agents are not effective against viral infections, such as the common cold or flu. Misuse and overuse of antibiotics can lead to antibiotic resistance, which is a significant global health concern.

Thiamphenicol (also known as thiophenicol and dextrosulphenidol) is an antibiotic. It is the methyl-sulfonyl analogue of ... In pigs and rats the drug is excreted both as parent drug and as thiamphenicol glucuronate (FAO, 1997). A. Fisch, A. Bryskier ( ... Unlike chloramphenicol, thiamphenicol is not readily metabolized in cattle, poultry, sheep, or humans, but is predominantly ... Marchese A, Debbia E, Tonoli E, Gualco L, Schito A (2002). "In vitro activity of thiamphenicol against multiresistant ...
Click to view prices and info for Thiamphenicol on TOKU-E.com ... Resistance to Thiamphenicol may be due to decreased cell ... Both thiamphenicol and chloramphenicol work by the same mechanism, however, Thiamphenicol is about 3X as potent. After entering ... Thiamphenicol is a bacteriostatic antibiotic derived from chloramphenicol. Like chloramphenicol, Thiamphenicol is insoluble in ... Thiamphenicol was used for contamination control in hybrid walnut propagation. In addition to other antibiotics used during the ...
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More recently, good results have been reported with norfloxacin and thiamphenicol. The treatment of donovanosis in pregnant ...
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The pharmacokinetics of thiamphenicol in lactating cows por: Mestorino, Olga Nora, et al. Publicado: (1993) ...
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2. Thiamphenicol. Thiamphenicol dia derivative of chloramphenicol. Ny karazany sy ny tanjaky ny bakteria dia mitovy aminny ... Ny Thiamphenicol dia misy fanoherana tanteraka miaraka aminny chloramphenicol ary fanoherana ampahany aminny tetracyclines. ... Fitantanana ny biby fiompy sy akoho amam-borona (kajy aminny thiamphenicol) Dosis: 5-10 mg / kg lanjanny vatana. Ho anny ... Antibiotika izay tsy mahazo ampiasaina aminny vokatra akoho aondrana: chloramphenicol, gentamicin, thiamphenicol, avermycin, ...
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  • Thiamphenicol is a bacteriostatic antibiotic derived from chloramphenicol. (toku-e.com)
  • Like chloramphenicol, Thiamphenicol is insoluble in water but highly soluble in lipids. (toku-e.com)
  • Both thiamphenicol and chloramphenicol work by the same mechanism, however, Thiamphenicol is about 3X as potent. (toku-e.com)
  • Effects of Thiamphenicol and Chloramphenicol in Inhibiting Neisseria Gonorrhoeae Isolates. (toku-e.com)
  • In preliminary studies we also observed that NAC protects bone marrow cells from the growth-inhibitory effects of chloramphenicol and thiamphenicol 16 1 2009 Chloramphenicol Nitroso-chloramphenicol Thiamphenicol N-acetylcysteine. (karger.com)
  • Ny antibiotika Chloramphenicol dia ahitana ny chloramphenicol, thiamphenicol ary florfenicol. (ballyabio.com)
  • Thiamphenicol dia derivative of chloramphenicol. (ballyabio.com)
  • Ny Thiamphenicol dia misy fanoherana tanteraka miaraka amin'ny chloramphenicol ary fanoherana ampahany amin'ny tetracyclines. (ballyabio.com)
  • The method cross-reacts with florfenicol, a drug used to treat bovine respiratory disease, as well as thiamphenicol and the metabolite chloramphenicol glucuronide. (charm.com)
  • Replacement of the p- NO 2 group by a methylsulfonyl (HC 3 -SO 2 ) moiety produces thiamphenicol and a substantial change in biological activity, while modification of the propanediol group by the addition of a fluorine atom produces florfenicol. (veteriankey.com)
  • Both of these are discussed in more detail in Sections Thiamphenicol and Florfenicol. (veteriankey.com)
  • After entering a bacterial cell, Thiamphenicol binds to the 50S ribosomal subunit preventing peptide bond formation. (toku-e.com)
  • Thiamphenicol acetylcysteinate glycinate for inhalation is classified in J01BA52. (whocc.no)
  • Resistance to Thiamphenicol may be due to decreased cell permeability or a mutation in the 50S ribosomal subunit. (toku-e.com)
  • The pharmacokinetics of thiamphenicol in lactating cows por: Mestorino, Olga Nora, et al. (siu.edu.ar)
  • Thiamphenicol is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. (toku-e.com)
  • Thiamphenicol is a broad-spectrum antibiotic commonly used to target bacteria responsible for causing sexually transmitted diseases. (toku-e.com)
  • citation needed] Thiamphenicol is also widely used in Brazil, particularly for the treatment of sexually transmitted infections and pelvic inflammatory disease. (wikipedia.org)
  • Aminoacetic Acid is used as an intermediate of the medicine such as thiamphenicol. (atamanchemicals.com)
  • More recently, good results have been reported with norfloxacin and thiamphenicol. (bmj.com)
  • Inopha is Thiamphenicol API supplier in China. (inopha.net)
  • In cattle, goats and sheep: - Treatment of infections of the claw and hoof such as foot rot, interdigital dermatitis, digital dermatitis caused by micro-organisms susceptible to thiamphenicol. (dechra.co.uk)
  • Thiamphenicol, raw material of antibiotic medicine for the treatment of infectious diseases in cattle, pigs and poultry. (inopha.net)
  • In-vitro antibacterial activity of Sch 25393, a fluorinated analogue of thiamphenicol. (nih.gov)
  • Oral administration of livestock and poultry (calculated by thiamphenicol) Dose: 5-10 mg/kg body weight. (ballyabio.com)
  • Description: Thiamphenicol drug residue ELISA Kit is intended for the quantitative determination of Thiamphenicol drug residue in raw milk, egg, seafood, tissue. (influenza-x.org)
  • 9. UPLC-MS/MS determination of thiamphenicol in human plasma and its application to a pharmacokinetic study. (nih.gov)
  • citation needed] Thiamphenicol is also widely used in Brazil, particularly for the treatment of sexually transmitted infections and pelvic inflammatory disease. (wikipedia.org)
  • In all target species: - Treatment of superficial wound infections caused by micro-organisms susceptible to thiamphenicol. (dechra.co.uk)
  • In pigs and rats the drug is excreted both as parent drug and as thiamphenicol glucuronate (FAO, 1997). (wikipedia.org)

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