Slow Virus Diseases
Pulmonary Adenomatosis, Ovine
Marburg Virus Disease
Ross River virus
Hemorrhagic Fevers, Viral
Alphavirus Infections
Creutzfeldt--Jakob disease. (1/23)
The laboratory transmission to animals of an apparently degenerative disease of the nervous system, Creutzfeldt-Jakob disease (CJD), is now well established. Important questions arising from this observation are the possibility of natural transmission or infectivity and the existence of other similarly transmissible diseases. Epidemiological studies have revealed some possible clusters of CJD and also an association with previous craniotomy, but there is no definite evidence of natural infection. A few instances have been reported of experimental CJD in animals following inoculation with material from Alzheimer's disease, but apart from this there is so far no evidence of transmission of any other form of degenerative nervous disease. (+info)Effects of 5-bromodeoxyuridine and 5-iododeoxyuridine on a latent herpes simplex virus infection. (2/23)
A latent herpes simplex virus infection was established in rabbit kidney cells. Treatment of the cells with 5-bromo-2-deoxyuridine after the latent infection was established had no effect on the rate of virus recovery but did extend the latent period before active virus growth resumed. In contrast to this, treatment of cells with 5-bromo-2-deoxyuridine or 5-iodo-2-deoxyuridine prior to infection with virus increased the subsequent rate of virus recovery. (+info)Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene. (3/23)
BACKGROUND: We previously described two members of a family affected by an apparently genetically determined fatal disease characterized clinically by progressive insomnia, dysautonomia, and motor signs and characterized pathologically by severe atrophy of the anterior ventral and mediodorsal thalamic nuclei. Five other family members who died of this disease, which we termed "fatal familial insomnia," had broader neuropathologic changes suggesting that fatal familial insomnia could be a prion disease. METHODS: We used antibodies to prion protein (PrP) to perform dot and Western blot analyses, with and without proteinase K, on brain tissue obtained at autopsy from two patients with fatal familial insomnia, three patients with sporadic Creutzfeldt-Jakob disease, and six control subjects. The coding region of the PrP gene was amplified and sequenced in the samples from the two patients with fatal familial insomnia. Restriction-enzyme analysis was carried out with amplified PrP DNA from 33 members of the kindred. RESULTS: Protease-resistant PrP was found in both patients with fatal familial insomnia, but the size and number of protease-resistant fragments differed from those in Creutzfeldt-Jakob disease. In the family with fatal familial insomnia, all 4 affected members and 11 of the 29 unaffected members had a point mutation in PrP codon 178 that results in the substitution of asparagine for aspartic acid and elimination of the Tth111 I restriction site. Linkage analysis showed a close relation between the point mutation and the disease (maximal lod score, 3.4 when theta was zero). CONCLUSIONS: Fatal familial insomnia is a prion disease with a mutation in codon 178 of the PrP gene, but the disease phenotype seems to differ from that of previously described kindreds with the same point mutation. (+info)Persistent or slow viral infections and related diseases. (4/23)
The discovery of persistent transmissible agents by veterinarians has led to striking advances in the infectious cause of neuropathies of human beings. There is evidence for persisting infection in congenital rubella and the herpes group of viruses including cytomegalovirus infections. Hepatitis types A and B are candidates for inclusion in the category of persisting viral infections. The rubeola or measles virus is established as a persistent virus which causes elevated antibodies in the serum and cerebrospinal fluid of many patients with severe demyelinating disease such as subacute sclerosing panencephalitis and multiple sclerosis. Elevated antibodies against vaccinia virus have been found in the cerebrospinal fluid of some patients with multiple sclerosis and neuromyelitis optica, a rare form of multiple sclerosis. (+info)Morphological and virological investigations of cell strains cultured from the brain in Jakob-Creutzfeldt disease and subacute sclerosing panencephalitis. (5/23)
Cell strains were established in culture from fragments of the brain from 2 cases each of Jakob-Creutzfeldt (JC) disease and subacute sclerosing panencephalitis (SSPE). After about 12 weeks strains from the former spontaneously formed persistent heaped up nodules of cells which appeared to produce reticulin-like fibrils as well as confluent sheets of rounded and spindle, fibroblast-like cells. Similar sheets of cells were obtained from the cases of SSPE but the only nodules formed were smaller and ephemeral. Attempts to detect virus in all 4 strains were made by inoculation of supernatant fluids into cultures of other laboratory cells, haemadsorption, co-cultivation, electron microscopy and immunofluorescence, and testing for interferon production. No evidence was found by any of these methods of the persistent presence of virus in the strains. Immunofluorescence revealed a probable anti-glial cell IgM autoantibody in one case of JC disease. Morphologically some cells resembled astrocytes and others fibroblasts. Those from JC disease contained more vacuoles and redundant membranes than did those from the cases of SSPE, features that are particularly striking in brain cells in human and animal cases of the spongiform encephalopathies. (+info)Epidemiological and experimental studies on a new incident of transmissible mink encephalopathy. (6/23)
Epidemiological investigation of a new incident of transmissible mink encephalopathy (TME) in Stetsonville, Wisconsin, U.S.A. in 1985 revealed that the mink rancher had never fed sheep products to his mink but did feed them large amounts of products from fallen or sick dairy cattle. To investigate the possibility that this occurrence of TME may have resulted from exposure to infected cattle, two Holstein bull calves were injected intracerebrally with mink brain from the Stetsonville ranch. Each bull developed a fatal spongiform encephalopathy 18 and 19 months after inoculation, respectively, and both bovine brains passaged back into mink were highly pathogenic by either intracerebral or oral inoculation. These results suggest the presence of a previously unrecognized scrapie-like infection in cattle in the United States. (+info)Pathogenesis of the slow disease of the central nervous system associated with WM 1504 E virus. I. Relationship of strain susceptibility and replication to disease. (7/23)
Inbred mouse strains vary considerably in their susceptibility to the chronic neurologic disease caused by WM 1504 E virus. Although all strains inoculated with the virus showed evidence of viral replication, those strains destined to develop chronic disease showed consistently higher titers of viral antigen in their sera and also in their tissues, particularly in the central nervous system, than did resistant strains. Studies of hybrids made by mating susceptible C57BR/cdJ and resistant C57BL/6J strains indicated that resistance is dominant and not sex linked. The major areas of injury included neurons in the anterior horn of the spinal cord, the dentate nucleus of the cerebellum, and other nuclei in the brain stem. Involvement of oligodendrocytes with associated primary demyelination was also noted. Tissue damage accompanied intense gliosis but was without leukocyte infiltration. Immunopathologic studies and parabiotic experiments suggested that tissue injury was likely due to primary direct viral effects. Further, thymus-insufficient nude mice developed this chronic neurologic disease. (+info)Virus mutation during 'slow infection': temporal development and characterization of mutants of visna virus recovered from sheep. (8/23)
Visna virus could be recovered from peripheral blood leukocytes of sheep for years after intracerebral inoculation. Viruses recovered from sheep prior to and several months after development of antibody were antigenically identical to the parental strain used for inoculation. Subsequently, mutant viruses which were not neutralized by the animals' sera were obtained. Longitudinal studies of leukocyte viruses collected from two infected sheep showed that more than one strain of virus could co-exist in the animal. Virus neutralization tests using sequentially collected sera and the viruses recovered from leukocytes revealed a sequential development of antibody to parental and then to each strain of mutant virus. Characterization of two of the mutant viruses showed that they were antigenically stable, virulent in cell culture and when inoculated into new sheep, elicited antibodies which cross reacted with the parental virus from which they were derived. This continuous mutation of Visna virus in persistently infected sheep may be a mechanism for the production of chronic disease. (+info)Slow virus diseases, also known as persistent viral infections or chronic viral infections, are characterized by a lengthy incubation period and a slow progression of symptoms. These viruses can remain dormant in the body for extended periods, sometimes even years, before they start causing damage to cells and tissues.
The term "slow virus" is somewhat misleading because it does not necessarily mean that the virus itself is slow-replicating. Instead, it refers to the fact that the disease progression is slow and can take a long time to manifest symptoms. The immune system may have difficulty recognizing and eliminating these viruses, allowing them to persist in the body and cause ongoing damage over time.
Examples of slow virus diseases include:
1. Progressive multifocal leukoencephalopathy (PML): A rare and serious brain infection caused by the JC virus that primarily affects people with weakened immune systems, such as those with HIV/AIDS or those taking immunosuppressive drugs.
2. Subacute sclerosing panencephalitis (SSPE): A progressive neurological disorder caused by a measles virus infection that has become persistent in the brain. It primarily affects children and young adults who had measles during their early childhood.
3. Kuru: A rare, fatal degenerative neurological disorder that was once prevalent among the Fore people of Papua New Guinea. It is caused by an infectious protein called a prion, which can be transmitted through cannibalistic practices.
4. Creutzfeldt-Jakob disease (CJD): A rare and fatal brain disorder caused by prions. There are several types of CJD, including sporadic, hereditary, and acquired forms. The acquired form is a slow virus disease that can be transmitted through contaminated surgical instruments or dura mater grafts.
5. Human T-lymphotropic virus type 1 (HTLV-1) infection: A retrovirus that can cause adult T-cell leukemia/lymphoma and a progressive neurological disorder called HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).
6. Progressive multifocal leukoencephalopathy (PML): A rare, often fatal demyelinating disease of the central nervous system caused by the JC polyomavirus. It primarily affects individuals with weakened immune systems, such as those with HIV/AIDS or those receiving immunosuppressive therapy for organ transplantation.
I'm sorry for any confusion, but "Viruses, Unclassified" is not a recognized medical or scientific category. Generally, viruses are classified based on various characteristics such as genome structure, mode of replication, host range, and symptoms they cause. The International Committee on Taxonomy of Viruses (ICTV) is the organization responsible for the formal classification of viruses.
If you have any specific questions about certain unclassified viral entities or phenomena, I'd be happy to help if I can! Please provide more context so I can give a more accurate and helpful response.
Pulmonary Adenomatosis, Ovine, also known as Jaagsiekte or ovine pulmonary carcinoma, is a contagious and fatal disease that affects the lungs of sheep. It is caused by a retrovirus called jaagsiekte sheep retrovirus (JSRV). The virus infects the cells in the lung tissue leading to the formation of tumors known as adenomatosis.
The disease is characterized by progressive respiratory distress, weight loss, and eventual death. It is transmitted through the respiratory route, and infected animals can shed the virus in their saliva, nasal secretions, and feces. The disease has a long incubation period, which can range from several months to years, making it difficult to control.
There is no effective treatment for pulmonary adenomatosis, ovine, and infected animals are usually euthanized to prevent the spread of the virus. Prevention measures include quarantine and testing of new sheep before introducing them into a flock, as well as reducing stress and maintaining good nutrition and overall health in the flock.
Marburg Virus Disease (MVD) is an acute and often fatal viral hemorrhagic fever illness caused by the Marburg virus, a member of the filovirus family. It's a highly infectious disease that can be transmitted from human to human through direct contact with infected bodily fluids, tissues, or indirectly through contaminated surfaces and materials.
The incubation period for MVD ranges from 2 to 21 days, after which symptoms such as fever, chills, headache, muscle aches, severe malaise, and progressive weakness appear. Around the fifth day of illness, a maculopapular rash may occur, followed by diarrhea, nausea, vomiting, abdominal pain, and non-bloody stools. In some cases, patients may develop severe bleeding disorders, shock, liver failure, and multi-organ dysfunction, which can lead to death in 24-48 hours.
Currently, there are no approved vaccines or antiviral treatments for MVD, but supportive care is crucial for managing the symptoms of the disease. Preventive measures such as avoiding contact with infected individuals and their bodily fluids, wearing protective clothing, and practicing good hygiene can help prevent the spread of the virus.
Viral diseases are illnesses caused by the infection and replication of viruses in host organisms. These infectious agents are obligate parasites, meaning they rely on the cells of other living organisms to survive and reproduce. Viruses can infect various types of hosts, including animals, plants, and microorganisms, causing a wide range of diseases with varying symptoms and severity.
Once a virus enters a host cell, it takes over the cell's machinery to produce new viral particles, often leading to cell damage or death. The immune system recognizes the viral components as foreign and mounts an immune response to eliminate the infection. This response can result in inflammation, fever, and other symptoms associated with viral diseases.
Examples of well-known viral diseases include:
1. Influenza (flu) - caused by influenza A, B, or C viruses
2. Common cold - usually caused by rhinoviruses or coronaviruses
3. HIV/AIDS - caused by human immunodeficiency virus (HIV)
4. Measles - caused by measles morbillivirus
5. Hepatitis B and C - caused by hepatitis B virus (HBV) and hepatitis C virus (HCV), respectively
6. Herpes simplex - caused by herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2)
7. Chickenpox and shingles - both caused by varicella-zoster virus (VZV)
8. Rabies - caused by rabies lyssavirus
9. Ebola - caused by ebolaviruses
10. COVID-19 - caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Prevention and treatment strategies for viral diseases may include vaccination, antiviral medications, and supportive care to manage symptoms while the immune system fights off the infection.
Ross River virus (RRV) is an infectious disease caused by the Ross River virus, which is a type of alphavirus. It is transmitted to humans through the bite of infected mosquitoes, primarily Aedes vigilax, Culex annulirostris, and Culex australicus in Australia.
RRV is endemic to Australia, Papua New Guinea, and some islands in the Pacific Ocean. The symptoms of RRV include fever, rash, joint pain and swelling, muscle aches, fatigue, and headache, which can last for several weeks to months. In severe cases, it can lead to chronic arthritis and other long-term complications.
There is no specific treatment for RRV, and management typically involves relieving symptoms with rest, fluids, and pain relief medications. Preventive measures include avoiding mosquito bites by using insect repellent, wearing protective clothing, and staying indoors during peak mosquito activity hours.
**Hemorrhagic fevers, viral** are a group of severe, potentially fatal illnesses caused by viruses that affect the body's ability to regulate its blood vessels and clotting abilities. These viruses belong to several different families including *Filoviridae* (e.g., Ebola, Marburg), *Arenaviridae* (e.g., Lassa, Machupo), *Bunyaviridae* (e.g., Hantavirus, Crimean-Congo hemorrhagic fever virus) and *Flaviviridae* (e.g., Dengue, Yellow Fever).
The initial symptoms are non-specific and include sudden onset of fever, fatigue, muscle aches, joint pains, headache, and vomiting. As the disease progresses, it may lead to capillary leakage, internal and external bleeding, and multi-organ failure resulting in shock and death in severe cases.
The transmission of these viruses can occur through various means depending on the specific virus. For example, some are transmitted via contact with infected animals or their urine/feces (e.g., Hantavirus), others through insect vectors like ticks (Crimean-Congo hemorrhagic fever) or mosquitoes (Dengue, Yellow Fever), and yet others through direct contact with infected body fluids (Ebola, Marburg).
There are no specific treatments for most viral hemorrhagic fevers. However, some experimental antiviral drugs have shown promise in treating certain types of the disease. Supportive care, such as maintaining blood pressure, replacing lost fluids and electrolytes, and managing pain, is critical to improving outcomes. Prevention measures include avoiding areas where the viruses are common, using personal protective equipment when caring for infected individuals or handling potentially contaminated materials, and controlling insect vectors.
Sources: Centers for Disease Control and Prevention (CDC), World Health Organization (WHO).
Alphavirus infections refer to a group of diseases caused by viruses belonging to the Alphavirus genus of the Togaviridae family. These viruses are transmitted to humans through the bite of infected mosquitoes, and can cause a range of symptoms depending on the specific virus and the individual's immune response.
Some of the more common alphaviruses that cause human disease include:
* Chikungunya virus (CHIKV): This virus is transmitted by Aedes mosquitoes and can cause a fever, rash, and severe joint pain. While most people recover from CHIKV infection within a few weeks, some may experience long-term joint pain and inflammation.
* Eastern equine encephalitis virus (EEEV): This virus is transmitted by mosquitoes that feed on both birds and mammals, including humans. EEEV can cause severe neurological symptoms such as fever, headache, seizures, and coma. It has a high mortality rate of up to 30-50% in infected individuals.
* Western equine encephalitis virus (WEEV): This virus is also transmitted by mosquitoes that feed on both birds and mammals. WEEV can cause mild flu-like symptoms or more severe neurological symptoms such as fever, headache, and seizures. It has a lower mortality rate than EEEV but can still cause significant illness.
* Venezuelan equine encephalitis virus (VEEV): This virus is transmitted by mosquitoes that feed on horses and other mammals, including humans. VEEV can cause mild flu-like symptoms or more severe neurological symptoms such as fever, headache, and seizures. It is considered a potential bioterrorism agent due to its ability to cause severe illness and death in large populations.
There are no specific treatments for alphavirus infections other than supportive care to manage symptoms. Prevention measures include avoiding mosquito bites through the use of insect repellent, wearing long sleeves and pants, and staying indoors during peak mosquito hours. Public health efforts also focus on reducing mosquito populations through environmental controls such as eliminating standing water and using insecticides.
Respiratory Syncytial Virus (RSV) infections refer to the clinical illnesses caused by the Respiratory Syncytial Virus. RSV is a highly contagious virus that spreads through respiratory droplets, contact with infected surfaces, or direct contact with infected people. It primarily infects the respiratory tract, causing inflammation and damage to the cells lining the airways.
RSV infections can lead to a range of respiratory illnesses, from mild, cold-like symptoms to more severe conditions such as bronchiolitis (inflammation of the small airways in the lungs) and pneumonia (infection of the lung tissue). The severity of the infection tends to depend on factors like age, overall health status, and presence of underlying medical conditions.
In infants and young children, RSV is a leading cause of bronchiolitis and pneumonia, often resulting in hospitalization. In older adults, people with weakened immune systems, and those with chronic heart or lung conditions, RSV infections can also be severe and potentially life-threatening.
Symptoms of RSV infection may include runny nose, cough, sneezing, fever, wheezing, and difficulty breathing. Treatment typically focuses on managing symptoms and providing supportive care, although hospitalization and more aggressive interventions may be necessary in severe cases or for high-risk individuals. Preventive measures such as hand hygiene, wearing masks, and avoiding close contact with infected individuals can help reduce the spread of RSV.
Slow virus
Cypovirus
Björn Sigurðsson
Margrét Guðnadóttir
National Institutes of Health
Paget's disease of bone
Neurovirology
Progressive multifocal leukoencephalopathy
Subacute sclerosing panencephalitis
Progressive rubella panencephalitis
Neurotropic virus
Tick-borne encephalitis
Hirano body
Asao Hirano
Cassava brown streak virus disease
GB virus C
Batten disease
Stress in early childhood
Julius Youngner
Zidovudine
Swedish government response to the COVID-19 pandemic
Taq polymerase
Psittacine beak and feather disease
Slow bee paralysis virus
2015-16 Zika virus epidemic
FightAIDS@Home
World Community Grid
Viral load monitoring for HIV
Heiko Braak
Temporal network
Slow Viruses And Chronic Disease: The Contribution Of Epidemiology
Slow virus - Wikipedia
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Investment Property
Animal Viruses: Their Transmission and the Diseases They Produce Archives - FutureLearn
Infections18
- Bacteria, fungi, and viruses can all cause infections of the penis. (medicalnewstoday.com)
- The adenovirus is a common human virus, responsible for an estimated 10 percent of respiratory infections in children and a frequent cause of diarrhea. (survivingmesothelioma.com)
- If domestic transmission were stopped, infections may still continue if people catch the virus while traveling internationally, he said. (fox5atlanta.com)
- Monkeypox is endemic in parts of Africa, where people have been infected through bites from rodents or small animals, but it wasn't considered a disease that spreads easily among people until May, when infections emerged in Europe and the U.S. (fox5atlanta.com)
- Cytotoxic T cells are an important component of the immune system, but when faced with serious infections or advanced cancer, they are often unable to proliferate in large enough quantities to fight the disease. (innovationtoronto.com)
- With most infections, vaccines buy the body more time to clear the infection on its own before disease occurs. (healthline.com)
- YOU are your best defense against viruses and other infections. (katdesignstudio.com)
- Non-polio enteroviruses are very common viruses, causing 10 to 15 million infections in the U.S. each year, according to the Centers for Disease Control and Prevention (CDC). (katdesignstudio.com)
- Immunity to influenza virus infections, as in the case of any other viral infections, has two essential components that act in a sequential and coordinated way. (futurelearn.com)
- Future work will identify the most effective ways to test for the virus in order to clear infections from the flock and investigate cheap and practical methods to control the disease, such as keeping ewes of different age-groups in separate pens when housed. (ed.ac.uk)
- It is likely that SARS-CoV-2 will establish as an endemic virus of humans, which has the potential to lead to reverse zoonotic infections in animals that live close to humans. (gla.ac.uk)
- There have been sporadic reports of infections in pet cats in COVID-households, which demonstrates that cats are susceptible to SARS-CoV-2 infection and could act as virus reservoirs. (gla.ac.uk)
- Recently cat-to-human transmission was reported, demonstrating that a successful cross-species jump of SARS-CoV-2 into cats has the potential to expand the host range of the virus and generate an additional source of infections for humans and other species. (gla.ac.uk)
- SYDNEY (Reuters) - More than 150 Australian economists on Monday warned the government against easing social distancing rules aimed at halting the spread of the new coronavirus even as the rate of infections slowed to a multi-week low. (metro.us)
- Australia's three most populated states on Monday recorded just seven new coronavirus infections in the last 24 hours, stoking hopes that Canberra could even eradicate the virus. (metro.us)
- common virus that can cause serious lung infections) in children less than 24 months old who are at high risk for getting RSV. (medlineplus.gov)
- If your child has an RSV infection, he should still continue to receive his scheduled palivizumab injections to help prevent serious disease from new RSV infections. (medlineplus.gov)
- The HIV-1 gag and env genes amplified from blood plasma samples of a unique cohort of acute HIV-1 infections are analyzed in this project with the aim to assess virus adaptations during acute HIV-1 infection and how these relates to the replicative capacity of the virus. (lu.se)
Subacute sclerosing pane2
- Examples of slow virus diseases include HIV/AIDS, caused by the HIV virus, subacute sclerosing panencephalitis, the rare result of a measles virus infection, and Paget's disease of bone (osteitis deformans), which may be associated with paramyxoviruses, especially the measles virus and the human respiratory syncytial virus. (wikipedia.org)
- Conventional viruses produce slow virus diseases such as SUBACUTE SCLEROSING PANENCEPHALITIS , progressive multifocal leukoencephalopathy ( LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL ), and AIDS . (nih.gov)
Coronavirus5
- You can help slow the spread of coronavirus through practical steps! (katdesignstudio.com)
- COVID-19, the disease caused by the novel coronavirus , has rapidly spread and reached the stage of pandemic . (cnet.com)
- Those are high priority for the health care workers that are taking care of people who have coronavirus disease," Fauci said. (cnet.com)
- Coronavirus disease 2019 (COVID-19) is a worldwide public health emergency. (who.int)
- The cause of the disease named coronavirus disease 2019 (COVID-19) was a new virus strain called severe acute respiratory coronavirus 2 (SARS-CoV-2) (2). (who.int)
Infection20
- Infection by VMV and CAEV can lead to Visna/Maedi (VM) and Caprine Arthritis-Encephalitis (CAE) respectively, slow progressive inflammatory diseases primarily affecting the lungs, nervous system, joints and mammary glands. (mdpi.com)
- Previous research suggests that HIV-2 infection protects against subsequent HIV-1 infection and, in cases of dual infection, slows the rate of HIV-1 disease progression. (medscape.com)
- As of May 5, using an updated case definition of fever plus cough or sore throat for a suspected case and real-time reverse transcription--polymerase chain reaction (rRT-PCR) or viral culture for a laboratory-confirmed case, Mexico had identified 11,932 suspected cases and 949* cases of laboratory-confirmed novel influenza A (H1N1) virus infection, including 42 patients who died. (cdc.gov)
- After recognition of the first cases of infection with the novel influenza A (H1N1) virus, CDC and state health departments initiated enhanced surveillance measures to identify additional cases. (cdc.gov)
- It is caused by infection with Ebola virus. (katdesignstudio.com)
- A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. (rush.edu)
- The most common symptoms are chronic respiratory disease and hardening of the udder, which only become evident some years after infection. (ed.ac.uk)
- Doctors and scientists have sequenced the genome of the virus and tracked its mutations , they studied the way it attacks the human body, and they found ways to fight off infection and help the immune system battle the illness. (bgr.com)
- Although the initial infection was isolated to only 59 people, this COVID-19-causing virus quickly spread to other areas and countries ( Hubbard, 2021 ), prompting the World Health Organization to declare COVID-19 a pandemic in March 2020. (frontiersin.org)
- PORTLAND, Ore. , April 15, 2014 /PRNewswire/ -- Banfield Pet Hospital®, the world's largest veterinary practice, released its State of Pet Health™ 2014 Report today, revealing a staggering 48 percent increase in the prevalence of feline immunodeficiency virus (FIV) infection in cats and a 21 percent increase in the prevalence of infection with the bacterium that causes Lyme disease in dogs. (prnewswire.com)
- and feline immunodeficiency virus (FIV) infection, feline leukemia virus (FeLV), upper respiratory infection and ear mites for cats. (prnewswire.com)
- Infectious Diseases in Cats, Areas of Potential Infection - Banfield Pet Hospital's State of Pet Health(TM) 2014 Report focuses on infectious diseases that can threaten the overall health of pets. (prnewswire.com)
- The risk of reverse zoonosis and the potential for the establishment of cats as a reservoir for SARS-CoV-2 is unknown, warranting the investigation of the susceptibility of cats to SARS-CoV-2 infection and their capacity to transmit the virus to cats and other species as the pandemic progresses. (gla.ac.uk)
- Dawson, M., Venables, C. and Jenkins, C.E. (1985): Experimental infection of a natural case of Sheep Pulmonary Adenomatosis with Maedi-Visna Virus. (siftdesk.org)
- When an influenza pandemic emerges, temporary school closures and antiviral treatment may slow virus spread, reduce the overall disease burden, and provide time for vaccine development, distribution, and administration while keeping a larger portion of the general population infection free. (cdc.gov)
- The high rate of virus spread have led to high rates of infection and mortality (8). (who.int)
- It has been suggested that different virological and immunological events during the very early stages of HIV infection may determine the rate of the future disease course of the individual patient. (lu.se)
- The detailed underlying mechanisms that determine differences in disease progression and clinical presentation of acute HIV infection (AHI) are largely unknown. (lu.se)
- The main goal of this project is to dissect the relationship between HIV-1 viral diversity, evolutionary dynamics, innate immune responses, and acute retroviral syndrome during acute HIV-1 infection, and how they contribute to disease pathogenesis during the acute and chronic stages of infection. (lu.se)
- Interestingly, the disease progression rate can vary considerably between individuals (with time to AIDS ranging between months to decades), and the immune specificity against HIV infection has been suggested to only explain about 22% of the most reliable predictor of when AIDS will develop? (lu.se)
Pandemic8
- In spite of pandemic fatigue , now is not the time to let up on safety measures that prevent transmission of the virus. (msmagazine.com)
- On April 29, WHO raised the level of pandemic alert from phase 4 to phase 5, indicating that human-to-human spread of the virus had occurred in at least two countries in one WHO region. (cdc.gov)
- Swine play a very important role as reservoirs for the diversity and pandemic threats of influenza A viruses. (futurelearn.com)
- The country has added a ban of gatherings of more than two people in a bid to slow the pandemic. (cnet.com)
- Dr. Redd says if a virus like that were to emerge today, "it would be a terrible event, and unfortunately, because flu is so unpredictable, there's no way to know whether the next flu pandemic will be as bad as 1918. (cdc.gov)
- When considering the impact of a pandemic today, Dr. Redd emphasizes that there are key differences in society and science today, compared to 1918, which would impact the spread of disease. (cdc.gov)
- To provide robust assessments of layered pandemic intervention strategies, the Centers for Disease Control and Prevention (CDC) funded a network of academic groups to build a framework for the development and comparison of multiple pandemic influenza models. (cdc.gov)
- Given the severity of the pandemic and lack of effective treatments, efforts were made to slow the spread of the disease to allow time to produce and administer effective vaccines and/or treatment (8,9). (who.int)
20201
- 2020). "Slow Viruses & Prions. (wikipedia.org)
Measles6
- Bone biopsies in patients with Paget disease have demonstrated antigens from several different Paramyxoviridae viruses, including measles virus and respiratory syncytial virus, located within osteoclasts. (medscape.com)
- Measles is a serious respiratory disease that is spread easily through coughing and sneezing. (katdesignstudio.com)
- It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (rush.edu)
- Measles is perhaps the most contagious infectious viral disease, with a basic reproduction number (R 0 ) estimated at between 12 and 18. (gla.ac.uk)
- Exiting through epithelial cells of the upper respiratory tract, measles virus is transmitted primarily through aerosols. (gla.ac.uk)
- To this end, we have developed measles virus pseudotypes with which virus neutralisation can be measured rapidly, safely and with high sensitivity. (gla.ac.uk)
Virology1
- Blake Wiedenheft is a researcher at Montana State University who launched his virology lab (which studies viruses) with help from. (medlineplus.gov)
Sexually Transmit1
- If you can avoid smoking, drinking too much alcohol, recreational drug use, and sexually transmitted diseases, you will probably find your HIV easier to control. (aids.org)
Chronic8
- Chronic wasting disease (CWD) of deer and elk is a widespread health concern because its potential for cross-species transmission is undetermined. (cdc.gov)
- Chronic wasting disease (CWD) is an emerging infectious disease first recognized in the 1960s. (cdc.gov)
- Here, we combined optimized prion amplification procedures with a statistical method that accounts for false positive and false negative errors to test deer saliva for chronic wasting disease (CWD) prions. (iowawhitetail.com)
- The mechanism of the chronic disease is different in both cases. (futurelearn.com)
- Chronic diseases are a real problem, especially if there are no clinical signs and the animal is left undiagnosed. (futurelearn.com)
- A collaboration between scientists in Scotland and The Netherlands has found that a lack of 'social distancing' between sheep is almost exclusively responsible for the spread of the virus that causes the chronic viral disease maedi-visna. (ed.ac.uk)
- About half the patients (48.3%) had a history of chronic disease. (who.int)
- Diabetes (16.2%), high blood pressure (14.8%) and cardiovascular disease (12.4%) were the most prevalent chronic diseases among patients who were confirmed positive for COVID-19. (who.int)
Immunity4
- Scientists have discovered a protein that plays a central role in promoting immunity to viruses and cancer, opening the door to new therapies. (innovationtoronto.com)
- That has been the case especially in some Hasidic neighborhoods of Brooklyn, where life largely returned to normal as early as May and June as many in these communities, including some doctors, believed they had achieved a level of herd immunity - meaning a large enough percentage of the community had acquired immunity after recovering from the virus to significantly slow the transmission of disease. (jta.org)
- In addition, mucosal immunity may prevent disease spread by limiting viral shedding. (ondrugdelivery.com)
- Once a large number of the population has acquired immunity via a vaccine or by surviving the disease, the spread of the virus will be slowed down significantly, and it could ultimately disappear. (bgr.com)
Mutate1
- When viruses mutate, as they frequently do, thwarting the action of drugs, the mutations typically occur in these sidechains. (news-medical.net)
Centers for Dis8
- U.S. Centers for Disease Control and Prevention. (wikipedia.org)
- The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
- The disease's spread is slowing but the virus is so widespread that elimination is unlikely, the Centers for Disease Control and Prevention said. (fox5atlanta.com)
- We continue to work with the Centers for Disease Control and Prevention (CDS) and the Tennessee Department of Health (TDH) to continue to provide a safe environment for all patients in our community. (katdesignstudio.com)
- This helps account for the slow response to the virus from the National Institutes of Health and the Centers for Disease Control. (usasurvival.org)
- Workers from the United States Centers for Disease Control (CDC) were ordered to leave the most high risk areas as a result. (telegraph.co.uk)
- This group has the highest death and hospitalization rates from the virus, Centers for Disease Control and Prevention data shows. (rollcall.com)
- Shipped to the Centers for Disease Control and Prevention for testing on a live virus, the prototype proved to be 1,000 times more effective than the original compound in inhibiting 3CLpro. (news-medical.net)
AIDS2
- Protease inhibitors, a class of drugs capable of disrupting enzymes that digest proteins, have been successfully used to thwart the human immunodeficiency virus, which causes AIDS. (news-medical.net)
- The test means that you are infected with the virus that causes AIDS, the human immunodeficiency virus (HIV). (aids.org)
Vaccines11
- Vaccines prompt your body to create antibodies that recognize a specific virus. (msmagazine.com)
- Most vaccines are made with killed or weakened viruses. (healthline.com)
- Most vaccines are prophylactic, which means they prevent a person from getting a disease. (healthline.com)
- Therapeutic vaccines, on the other hand, are used to increase the body's immune response to fight disease that the person already has. (healthline.com)
- Live vector vaccines use non-HIV viruses to carry HIV genes into the body to trigger an immune response. (healthline.com)
- Globally there is growing recognition that such products could support efficient long-term management of the SARS-CoV-2 virus, as evidenced by remarks from the White House Summit in the US on next-generation vaccines. (ondrugdelivery.com)
- The executive director till July of the Translational Health Sciences and Technology Institute, a public health research institute under the ministry of science and technology, when COVID-19 arrived in India Dr Kang's expertise was in evidence as she worked on indigenous solutions via vaccines and drugs and offered advice on public health policy for the disease, including apparently insisting that the private sector be roped in for testing. (rediff.com)
- Dr Kang discusses with Vaihayasi Pande Daniel/ Rediff.com vaccines, rural spread of COVID-19 and encourages every individual to look at personal actions, in this virus-governed climate, through a risk versus benefit prism. (rediff.com)
- All of these mitigation measures helped slow the spread of the virus and the efficient rollout of vaccines has accelerated the decline in disease. (rollcall.com)
- Researchers are already trialing several drugs that can speed up the recovery of patients as well, and they're devising several vaccines that can help eradicate the disease in the coming years. (bgr.com)
- We have the ability to detect flu viruses, and the ability to make vaccines to prevent flu. (cdc.gov)
Influenza Virus1
- CDC must remain vigilant in our preparation, but also in our ability to adapt and respond to the ever evolving influenza virus. (cdc.gov)
Retroviruses6
- The video names several retroviruses which produce important diseases in animals. (futurelearn.com)
- The replication process determines why retroviruses induce slow progressive diseases. (futurelearn.com)
- Certain single-strand, (+) sense RNA viruses termed retroviruses use a very different method of replication. (msdmanuals.com)
- Examples of retroviruses are the human immunodeficiency viruses and the human T-cell leukemia viruses. (msdmanuals.com)
- Because RNA transcription does not involve the same error-checking mechanisms as DNA transcription, RNA viruses, particularly retroviruses, are particularly prone to mutation. (msdmanuals.com)
- the genome of RNA viruses ranges from 3.5 kilobases (some retroviruses) to 27 kilobases (some reoviruses), and the genome of DNA viruses ranges from 5 kilobases (some parvoviruses) to 280 kilobases (some poxviruses). (msdmanuals.com)
Replication6
- This may be due to the slow replication rates some of these agents exhibit, preexisting immunosuppression (as in the cases of JC virus and BK virus), or, in the case of prions, the identity of the agent involved. (wikipedia.org)
- A prototype drug created by researchers at the University of Illinois at Chicago shows promise in slowing replication of the virus responsible for severe acute respiratory syndrome, or SARS. (news-medical.net)
- Data from SARS patients indicate that replication of the virus peaks 10 days after the onset of fever," said Michael Johnson, director of the Center for Pharmaceutical Biotechnology in the UIC College of Pharmacy and the study's principal investigator. (news-medical.net)
- Viral replication occurs in the upper and lower respiratory tract and shed infectious virus can be detected in nasal washes, oropharyngeal and rectal swabs, and viral RNA is detectable in faeces and occasionally urine. (gla.ac.uk)
- Some viruses have an outer envelope consisting of protein and lipid, surrounding a protein capsid complex with genomic RNA or DNA and sometimes enzymes needed for the first steps of viral replication. (msdmanuals.com)
- Classification of viruses is principally according to their genome sequence taking into consideration nature and structure of their genome and their method of replication, but not according to the diseases they cause (see International Committee on Taxonomy of Viruses (ICTV), 2021 release ). (msdmanuals.com)
Antibodies2
- It produces HIV antibodies, but they only slow the disease. (healthline.com)
- Development of an Enzyme-Linked Immunosorbent Assay Based on Fusion VP2332-452 Antigen for Detecting Antibodies against Aleutian Mink Disease Virus. (nih.gov)
Prion5
- JC virus & BK virus only cause disease in immunocompromised patients Was once thought to be due to a slow virus but is now known to be the result of Prion disease. (wikipedia.org)
- Because lymphoid tissues are important in the pathogenesis of some transmissible spongiform encephalopathies such as sheep scrapie, we investigated whether CWD-affected elk and deer differ in distribution or quantity of disease-associated prion protein (PrPres) in lymphoid tissues. (cdc.gov)
- CWD, like other TSE diseases, is characterized by the accumulation in neural tissues of an abnormal disease-associated prion protein designated PrPres ( 1 ), PrP Sc ( 2 ), or PrP d ( 3 ). (cdc.gov)
- They are now called PRION DISEASES . (nih.gov)
- This approach enabled us to discriminate shedding of prions in saliva and detection of prions in saliva -- a distinction crucial to understanding the role of prion shedding in disease transmission and for diagnosis. (iowawhitetail.com)
Paget16
- Paget disease is a localized disorder of bone remodeling that typically begins with excessive bone resorption followed by an increase in bone formation. (medscape.com)
- [ 3 ] Paget disease, as the condition came to be known, is the second most common bone disorder (after osteoporosis) in elderly persons. (medscape.com)
- Paget disease may involve a single bone but is more frequently multifocal. (medscape.com)
- After onset, Paget disease does not spread from bone to bone, but it may become progressively worse at preexisting sites. (medscape.com)
- Although the etiology of Paget disease is unknown, both genetic and environmental contributors have been suggested. (medscape.com)
- Ethnic and geographic clustering of Paget disease is well described. (medscape.com)
- In the United States, most, although not all, individuals with Paget disease are white. (medscape.com)
- A familial link for Paget disease was first reported by Pick in 1883, who described a father-daughter pair with Paget disease. (medscape.com)
- This was followed shortly thereafter with a sibling case of Paget disease described by Lunn in 1885. (medscape.com)
- Approximately 40% of persons with Paget disease report a family history of the disease, although the true prevalence of the disease is likely higher. (medscape.com)
- Some studies suggest a genetic linkage for Paget disease located on chromosome arm 18q. (medscape.com)
- This has not been demonstrated in most families with Paget disease, however, which suggests genetic heterogeneity. (medscape.com)
- An environmental trigger for Paget disease has long been considered but never proven. (medscape.com)
- Measurement of serum alkaline phosphatase-in some cases, bone-specific alkaline phosphatase (BSAP)-along with several urinary markers, can be useful in the diagnosis of Paget disease. (medscape.com)
- Three phases of Paget disease have been described: lytic, mixed lytic and blastic, and sclerotic. (medscape.com)
- Paget disease begins with the lytic phase, in which normal bone is resorbed by osteoclasts that are more numerous, are larger, and have many more nuclei (up to 100) than normal osteoclasts (5-10 nuclei). (medscape.com)
Infectious disease3
- They know their history and the devastating toll that infectious diseases have had," said Laura Hammitt, a Johns Hopkins Bloomberg School of Public Health associate professor and the director of the infectious disease prevention program at the Center for American Indian Health. (rollcall.com)
- The 2014 report highlights the increase in infectious disease observed at Banfield hospitals nationwide," said Jeffrey Klausner , DVM, MS, DACVIM, senior vice president and chief medical officer for Banfield Pet Hospital. (prnewswire.com)
- Right now, over 50 countries around the world are working through the GHSA to improve their ability to prevent, detect, and rapidly respond to infectious disease threats. (cdc.gov)
Spread of the virus8
- Taking often astonishing risks, health workers have administered nearly 20,000 vaccinations, a campaign that had slowed the spread of the virus before September's attack. (telegraph.co.uk)
- It is also useful to make inferences about the spread of the virus around the world, and what type of vaccine may be most effective. (livescience.com)
- I am a bioinformatician who studies the relationships between epidemics and viral evolution, and I am among the many researchers now studying the evolution of SARS-CoV-2 because it can help researchers and public health officials track the spread of the virus over time. (livescience.com)
- This type of information can help public health officials contain the spread of the virus. (livescience.com)
- Scientists from the University of Edinburgh, the Moredun Research Institute and GD Animal Health in The Netherlands found much higher rates of spread of the virus during periods of winter housing than between sheep kept at grass. (ed.ac.uk)
- We feel committed to consistent implementation of the action plan that has been introduced to slow the spread of the virus and the lung disease Covid-19 that can develop as a result. (bega.com)
- According to the Associated Press , Merkel was put into quarantine shortly after a press conference on Sunday where she announced some "new measures to curb the spread of the virus. (cnet.com)
- It works by helping the immune system to slow or stop the spread of the virus in the body. (medlineplus.gov)
Transmission7
- The government of Mexico has instituted several measures to slow disease transmission and reduce mortality, including closure of all schools and avoidance of large public gatherings, distribution of oseltamivir to all health-care units, publication of specific clinical guidelines, and establishment of a call center to educate members of the public who are seeking health-care information. (cdc.gov)
- This week we have learned about viruses which have a clear airborne transmission. (futurelearn.com)
- However, there has been no previous quantitative analysis of virus transmission under farm conditions. (ed.ac.uk)
- Even brief periods of housing allow it to spread, but transmission of the virus is negligible between sheep kept at grass. (ed.ac.uk)
- So although individual sheep never recover from the disease, it could be eliminated from flocks over time by exploiting the fact that transmission of the virus is too slow between grazing sheep to sustain the disease. (ed.ac.uk)
- Maternal transmission (from ewes to lambs) has only a small effect on disease spread. (ed.ac.uk)
- Building scenarios and strategies only on the basis of well-known pathogens risks failing to exploit all possible measures to slow transmission of the COVID-19 virus, reduce disease and save lives. (publicintelligence.net)
Patients7
- Patients infected with both viruses had slower disease progression than those infected with HIV-1 only. (medscape.com)
- Researchers in Japan are enrolling mesothelioma patients into a trial to test whether blocking a growth signaling pathway inside mesothelioma cells could slow down this aggressive cancer or even stop its progression. (survivingmesothelioma.com)
- For patients experiencing inflammation after the virus is gone, an anti-inflammatory therapy would be most appropriate. (medscape.com)
- The influenza strain identified in U.S. patients was genetically similar to viruses isolated from patients in Mexico ( 2 ). (cdc.gov)
- Among patients with confirmed disease for whom data were available, 262 (90%) of 292 reported fever, 249 (84%) of 296 reported cough, 176 (61%) of 290 reported sore throat, 65 (26%) of 249 reported diarrhea, and 54 (24%) of 221 reported vomiting. (cdc.gov)
- This guidance is intended to help clinicians in outpatient settings test for these fungal diseases in patients with CAP to reduce misdiagnoses, unnecessary antibacterial use, and poor outcomes. (cdc.gov)
- Importantly, this implies that up to 78% of the variation in HIV disease progression rate between patients remains to be explained. (lu.se)
Ebola4
- Ebola Virus Disease is a rare and deadly disease that is native to several African countries. (katdesignstudio.com)
- The source of the virus could be a natural epidemic like Ebola, or it could be bioterrorism. (usasurvival.org)
- A two-day suspension of control activities after a similar massacre in the city in late September had devastating consequences, with the number of Ebola cases doubling because aid workers lost track of the spread of the disease. (telegraph.co.uk)
- One such initiative is Nextstrain , an open-source project that provides users real-time reports of the spread of seasonal influenza , Ebola and many other infectious diseases. (livescience.com)
Immunodeficiency2
- Download the State of Pet Health(TM) 2014 Report and discover key findings on a wide range of pet health conditions and diseases such as feline immunodeficiency virus and feline leukemia virus, by visiting stateofpethealth.com. (prnewswire.com)
- Thirty-seven million individuals are currently infected with the human immunodeficiency virus (HIV) worldwide. (lu.se)
Epidemic1
- BSE is considered a "common source" epidemic, meaning that animals contract the disease from a common element in their environment. (wustl.edu)
Maedi Virus1
- Small ruminant lentiviruses (SRLV) are members of the Retrovirus family comprising the closely related Visna/Maedi Virus (VMV) and the Caprine Arthritis-Encephalitis Virus (CAEV), which infect sheep and goats. (mdpi.com)
Significantly2
- They also had a significantly higher mean CD4-cell percentage at the extrapolated time of seroconversion (31% vs. 23%) and a significantly slower increase in CD8-cell percentage over time. (medscape.com)
- Furthermore, their HIV-1 viruses exhibited significantly less genetic diversity over time, which also suggests an attenuating effect of HIV-2 on HIV-1 disease progression. (medscape.com)
Onset4
- The first clinical signs of the disease (onset) has been observed in cattle at an age of 1 year 10 months to 15 years. (wustl.edu)
- Mice inoculated with BSE brain homogenates develop neurological signs of the disease 300 to 450 days later, therefore, indicating a prolonged incubation period before onset. (wustl.edu)
- Diseases of viral origin, characterized by incubation periods of months to years, insidious onset of clinical manifestations, and protracted clinical course. (nih.gov)
- DEATH usually occurs 1-3 years after disease onset. (rush.edu)
Zika2
- it has also undertaken a desk review of the WHO response to the recent outbreak of yellow fever and a three-day field visit to Colombia for Zika virus disease. (who.int)
- From 2015 to 2016, the World Health Organization declared the Zika virus a world health crisis. (medlineplus.gov)
Outbreak3
- Since mid-April 2009, CDC, state and local health authorities in the United States, the World Health Organization (WHO), and health ministries in several countries have been responding to an outbreak of influenza caused by a novel influenza A (H1N1) virus ( 1 ). (cdc.gov)
- One overnight sports camp for boys in Pennsylvania had an outbreak of COVID-19 , sending eight boys back to their home communities on Long Island and several more to Baltimore, where others had contracted the virus after attending weddings or coming into contact with those who did. (jta.org)
- When a deadly disease outbreak hits, this can have devastating consequences. (cdc.gov)
Clinical2
- Medical Microbiology & Immunology: A Guide to Clinical Infectious Diseases (16th ed. (wikipedia.org)
- Clearly, this clinical advantage is critical, not just for SARS-CoV-2 but also for other respiratory viruses that share its method of attack. (ondrugdelivery.com)
Progression1
- Previous studies by us and others have suggested that differences in disease progression rate may be associated with both viral parameters, such as diversity or infecting subtype and host immune responses. (lu.se)
Types of viruses1
- It's so hard to develop a vaccine for HIV because it's different from other types of viruses. (healthline.com)
Prevalent1
- Pan·dem·ic /panˈdemik/ (of a disease) prevalent over a whole country or the world. (visualcapitalist.com)
Occurs1
- The disease occurs in all color types, but mink which are homozygous recessive for the Aleutian gene for light coat color are particularly susceptible. (nih.gov)
Primarily1
- BSE is an afebrile neurological disease that primarily affects mature cattle. (wustl.edu)
Genome4
- Much like our game of telephone, the genome sequence of the SARS-CoV-2 virus changes over time: Mutations occur randomly, and any changes that occur in a given virus will be inherited by all copies of the next generation. (livescience.com)
- Positive-sense RNA viruses possess a single-stranded RNA genome that can serve as messenger RNA (mRNA) that can be directly translated to produce an amino acid sequence. (msdmanuals.com)
- Negative-sense RNA viruses possess a single-stranded negative-sense genome that first must synthesize a complementary positive-sense antigenome, which is then used to make genomic negative-sense RNA. (msdmanuals.com)
- This manageable size together with the current advances in nucleotide sequencing technology means that partial and whole virus genome sequencing will become an essential component in epidemiologic investigations of disease outbreaks. (msdmanuals.com)
Diagnosis1
- It is our responsibility-as a practice and as a dedicated group of professionals who love pets-to provide the best possible preventive care, which leads to early disease diagnosis and management. (prnewswire.com)
Prevalence1
- This difference correlated with the natural prevalence of CWD in these species and suggested that CWD-infected deer may be more likely than elk to transmit the disease to other cervids and have a greater potential to transmit CWD to noncervids. (cdc.gov)
H1N12
- Since recognition of the novel influenza A (H1N1) virus in Mexico and the United States, as of May 6, a total of 21 additional countries had reported cases, with a total of 1,882 confirmed cases worldwide. (cdc.gov)
- This report provides an update of the initial investigations and spread of novel influenza A (H1N1) virus worldwide. (cdc.gov)
Pathogenesis2
- Most TSE researchers believe that PrPres is critical in disease pathogenesis, and some evidence suggests that PrPres may itself be the infectious agent ( 4 ). (cdc.gov)
- In other TSE diseases such as BSE and sporadic CJD, lymphoid tissues appear to play little or no essential role in disease pathogenesis ( 14 , 15 ). (cdc.gov)
Respiratory disease1
- and higher rates of lower respiratory disease as drivers of the COVID-19 disparity between American Indians and the rest of the country. (rollcall.com)
World Health Organ1
- During a discussion on Reddit, he failed to hold China responsible for claiming, through the World Health Organization, that the disease could not be transmitted between humans. (usasurvival.org)
Immune system1
- The immune system, which fights disease, doesn't respond to the HIV virus. (healthline.com)
Human3
- It is a member of the transmissible spongiform encephalopathy (TSE) disease group that includes sheep scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy, and several human diseases, including kuru, Creutzfeldt-Jakob disease (CJD), and variant CJD (vCJD). (cdc.gov)
- Experiments in mice and human cells have shown that the protein promotes the proliferation of cytotoxic T cells, which kill cancer cells and cells infected with viruses. (innovationtoronto.com)
- DNA sequencing is largely used to study human diseases and genetics, but in recent years, sequencing has become a routine part of viral point of care , and as sequencing becomes cheaper and cheaper , viral sequencing will become even more frequent as time progresses. (livescience.com)
Symptoms5
- The time between an animal being infected and becoming infectious is estimated to be about a year, which is consistent with the slow and progressive emergence of symptoms of MV. (ed.ac.uk)
- By administering protease inhibitors early, when feverish symptoms have started, the drugs could reduce the viral load and ameliorate the disease. (news-medical.net)
- No one can predict how long it may take to develop any symptoms of HIV disease. (aids.org)
- Palivizumab injection is not used to treat the symptoms of RSV disease once a child already has it. (medlineplus.gov)
- Talk to your child's healthcare provider about the symptoms of RSV disease. (medlineplus.gov)
Persistence2
- Despite the persistence of disease and pandemics throughout history, there's one consistent trend over time - a gradual reduction in the death rate. (visualcapitalist.com)
- He pointed out that two of the possible disease-driving mechanisms are persistence of the virus and prolonged inflammation that is slow to resolve. (medscape.com)
Rapidly2
- Like HIV, the SARS virus multiplies rapidly, hijacking the machinery of the cells it infects to clone itself over and over again. (news-medical.net)
- HIV is a virus that can multiply rapidly in your body. (aids.org)
Progresses1
- A slow virus disease is a disease that, after an extended period of latency, follows a slow, progressive course spanning months to years, frequently involves the central nervous system, and in most cases progresses to death. (wikipedia.org)
Vaccine4
- A vaccine targets a virus in a particular form. (healthline.com)
- If the virus changes, the vaccine may not work on it anymore. (healthline.com)
- What we are finding is that the SARS-CoV-2 virus appears to be mutating more slowly than the seasonal flu which may allow scientists to develop a vaccine. (livescience.com)
- The fact that so many laboratories have rushed to make a COVID-19 vaccine so quickly is excellent news and can help to make up for the slow start. (bgr.com)
Allergy2
- On the basis of their success, the researchers have received an $8 million grant from the National Institute of Allergy and Infectious Diseases to develop protease inhibitors that would block key enzymes in the SARS virus and hamper its advance. (news-medical.net)
- Also during the briefing, Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, urged people to forgo unnecessary tests and medical procedures, all of which reduce the supply of the personal protective gear needed for doctors and nurses. (cnet.com)
Outbreaks2
- In March and early April 2009, Mexico experienced outbreaks of respiratory illness subsequently confirmed by CDC and Canada to be caused by the novel virus. (cdc.gov)
- Tracking how viruses have changed in a location can also answer questions like, "How many separate outbreaks exist in my community? (livescience.com)
Genetic3
- By screening mice with genetic mutations, the Imperial team discovered a strain of mice that produced 10 times as many cytotoxic T cells when infected with a virus compared with normal mice. (innovationtoronto.com)
- Then, much as we could try to decode how "CAT" became "MAD," scientists can use models on genetic evolution to try to determine the most likely evolutionary history of the virus. (livescience.com)
- either DNA or RNA viruses may have single or double strands of genetic material. (msdmanuals.com)
Typically2
- Viruses are among the smallest microbes, typically ranging from 0.02 to 0.3 micrometer, although several very large viruses up to 1 micrometer in length (megavirus, pandoravirus) have recently been discovered. (msdmanuals.com)
- DNA viruses typically replicate in the host cell nucleus, and RNA viruses typically replicate in the cytoplasm. (msdmanuals.com)