Predicting SA-I mechanoreceptor spike times with a skin-neuron model. (1/36)
(+info)Targeted depletion of Polo-like kinase (Plk) 1 through lentiviral shRNA or a small-molecule inhibitor causes mitotic catastrophe and induction of apoptosis in human melanoma cells. (2/36)
(+info)Do cephalopods communicate using polarized light reflections from their skin? (3/36)
(+info)MicroRNA-mediated control in the skin. (4/36)
(+info)Epithelialization in oral mucous wound healing in terms of energy metabolism. (5/36)
PURPOSE: The purpose of this study was to clarify the "healing capacity" of wounds of the oral mucosa in comparison to those of the skin, and to evaluate the wound healing mechanism of oral mucosa using a cytobiological approach from the aspect of energy metabolism in oral keratinocytes. MATERIALS AND METHODS: Samples of epidermal and oral keratinocytes collected at surgery and of cultured oral keratinocytes were used to analyze (1) by gas chromatography the composition of fatty acids (16:0, 18:2, 20:4) in the cell membranes of keratinocytes, (2) by immunohistochemical staining of GLUT-1 antibody and specific PAS staining the localization of glucose metabolism, and (3) by RT-PCR and Western blotting the expression of GLUT-1 mRNA and of protein in the keratinocytes of the basal and parabasal layers of each epithelial tissue. RESULTS: 1. The % composition of palmitic acid (16:0) was significantly higher in buccal mucosal keratinocytes (27.18+/-3.74%) and in the gingiva (23.00+/-1.40%) than in the epidermis (17.54+/-0.37%). 2. Immunohistochemical staining showed GLUT-1 protein in the skin to be expressed only in the bulge region of hair follicles and in the epidermal basal layer, and observed nearly throughout all epithelial cell layers in the oral mucosa. 3. PAS-positive cells were observed among differentiation-enhanced cells in the upper prickle layer in the oral mucosa. 4. The same results were obtained from RT-PCR and a Western blotting analysis. CONCLUSION: The present study demonstrated definite cytobiological evidence that the oral mucosa surpasses the skin in regard to its wound healing capacity. (+info)Recent advances on skin-resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti-aging and cancer therapies. (6/36)
(+info)Functional coupling between motor and sensory nerves through contraction of sphincters in the pudendal area of the female cat. (7/36)
(+info)Fingertip moisture is optimally modulated during object manipulation. (8/36)
(+info)Skin physiological processes refer to the functions and changes that occur in the skin, which are necessary for its maintenance, repair, and regulation of body homeostasis. These processes include:
1. Barrier Function: The skin forms a physical barrier that protects the body from external factors such as microorganisms, chemicals, and UV radiation. It also helps to prevent water loss from the body.
2. Temperature Regulation: The skin plays a crucial role in regulating body temperature through sweat production and blood flow.
3. Immunological Function: The skin contains immune cells that help to protect the body against infection and disease.
4. Vitamin D Synthesis: The skin is able to synthesize vitamin D when exposed to sunlight.
5. Sensory Perception: The skin contains nerve endings that allow for the perception of touch, pressure, temperature, and pain.
6. Wound Healing: When the skin is injured, a complex series of physiological processes are initiated to repair the damage and restore the barrier function.
7. Excretion: The skin helps to eliminate waste products through sweat.
8. Hydration: The skin maintains hydration by regulating water loss and absorbing moisture from the environment.
9. Pigmentation: The production of melanin in the skin provides protection against UV radiation and determines skin color.
10. Growth and Differentiation: The skin constantly renews itself through a process of cell growth and differentiation, where stem cells in the basal layer divide and differentiate into mature skin cells that migrate to the surface and are eventually shed.
In medical terms, the skin is the largest organ of the human body. It consists of two main layers: the epidermis (outer layer) and dermis (inner layer), as well as accessory structures like hair follicles, sweat glands, and oil glands. The skin plays a crucial role in protecting us from external factors such as bacteria, viruses, and environmental hazards, while also regulating body temperature and enabling the sense of touch.