Sequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.Peptide Nucleic Acids: DNA analogs containing neutral amide backbone linkages composed of aminoethyl glycine units instead of the usual phosphodiester linkage of deoxyribose groups. Peptide nucleic acids have high biological stability and higher affinity for complementary DNA or RNA sequences than analogous DNA oligomers.Sequence Homology, Nucleic Acid: The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Nucleic Acid Hybridization: Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)Nucleic Acid Conformation: The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Sequence Homology: The degree of similarity between sequences. Studies of AMINO ACID SEQUENCE HOMOLOGY and NUCLEIC ACID SEQUENCE HOMOLOGY provide useful information about the genetic relatedness of genes, gene products, and species.Nucleic Acid Probes: Nucleic acid which complements a specific mRNA or DNA molecule, or fragment thereof; used for hybridization studies in order to identify microorganisms and for genetic studies.Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.Nucleic Acid Amplification Techniques: Laboratory techniques that involve the in-vitro synthesis of many copies of DNA or RNA from one original template.RNA: A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)Nucleic Acid Denaturation: Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Genes: A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.DNA, Complementary: Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.DNA Restriction Enzymes: Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1.DNA, Bacterial: Deoxyribonucleic acid that makes up the genetic material of bacteria.Plasmids: Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Oligonucleotides: Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)Restriction Mapping: Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.DNA, Viral: Deoxyribonucleic acid that makes up the genetic material of viruses.Genes, Bacterial: The functional hereditary units of BACTERIA.Protein Structure, Tertiary: The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Structural Homology, Protein: The degree of 3-dimensional shape similarity between proteins. It can be an indication of distant AMINO ACID SEQUENCE HOMOLOGY and used for rational DRUG DESIGN.Bacterial Proteins: Proteins found in any species of bacterium.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.RNA, Viral: Ribonucleic acid that makes up the genetic material of viruses.src Homology Domains: Regions of AMINO ACID SEQUENCE similarity in the SRC-FAMILY TYROSINE KINASES that fold into specific functional tertiary structures. The SH1 domain is a CATALYTIC DOMAIN. SH2 and SH3 domains are protein interaction domains. SH2 usually binds PHOSPHOTYROSINE-containing proteins and SH3 interacts with CYTOSKELETAL PROTEINS.Protein Conformation: The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Molecular Weight: The sum of the weight of all the atoms in a molecule.Open Reading Frames: A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).Recombinant Proteins: Proteins prepared by recombinant DNA technology.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.DNA Primers: Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Gene Library: A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.Conserved Sequence: A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. AMINO ACID MOTIFS are often composed of conserved sequences.Repetitive Sequences, Nucleic Acid: Sequences of DNA or RNA that occur in multiple copies. There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. Variations may be direct repeats, those occurring in the same direction, or inverted repeats, those opposite to each other in direction. TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted (INVERTED REPEAT SEQUENCES).Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.Kinetics: The rate dynamics in chemical or physical systems.Multigene Family: A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)Viral Proteins: Proteins found in any species of virus.Genes, Viral: The functional hereditary units of VIRUSES.Oligonucleotide Probes: Synthetic or natural oligonucleotides used in hybridization studies in order to identify and study specific nucleic acid fragments, e.g., DNA segments near or within a specific gene locus or gene. The probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the probe include the radioisotope labels 32P and 125I and the chemical label biotin.DNA Probes: Species- or subspecies-specific DNA (including COMPLEMENTARY DNA; conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32P and 125I and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Oligodeoxyribonucleotides: A group of deoxyribonucleotides (up to 12) in which the phosphate residues of each deoxyribonucleotide act as bridges in forming diester linkages between the deoxyribose moieties.Chromosome Mapping: Any method used for determining the location of and relative distances between genes on a chromosome.Blotting, Southern: A method (first developed by E.M. Southern) for detection of DNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.DNA, Single-Stranded: A single chain of deoxyribonucleotides that occurs in some bacteria and viruses. It usually exists as a covalently closed circle.Recombinant Fusion Proteins: Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.Protein Structure, Secondary: The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.Peptide Fragments: Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.RNA, Bacterial: Ribonucleic acid in bacteria having regulatory and catalytic roles as well as involvement in protein synthesis.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Blotting, Northern: Detection of RNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.Self-Sustained Sequence Replication: An isothermal in-vitro nucleotide amplification process. The process involves the concomitant action of a RNA-DIRECTED DNA POLYMERASE, a ribonuclease (RIBONUCLEASES), and DNA-DIRECTED RNA POLYMERASES to synthesize large quantities of sequence-specific RNA and DNA molecules.Biological Evolution: The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.Saccharomyces cerevisiae: A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Crystallography, X-Ray: The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Nucleic Acid Heteroduplexes: Double-stranded nucleic acid molecules (DNA-DNA or DNA-RNA) which contain regions of nucleotide mismatches (non-complementary). In vivo, these heteroduplexes can result from mutation or genetic recombination; in vitro, they are formed by nucleic acid hybridization. Electron microscopic analysis of the resulting heteroduplexes facilitates the mapping of regions of base sequence homology of nucleic acids.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Nucleic Acid Renaturation: The reformation of all, or part of, the native conformation of a nucleic acid molecule after the molecule has undergone denaturation.Plant Proteins: Proteins found in plants (flowers, herbs, shrubs, trees, etc.). The concept does not include proteins found in vegetables for which VEGETABLE PROTEINS is available.Plants: Multicellular, eukaryotic life forms of kingdom Plantae (sensu lato), comprising the VIRIDIPLANTAE; RHODOPHYTA; and GLAUCOPHYTA; all of which acquired chloroplasts by direct endosymbiosis of CYANOBACTERIA. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (MERISTEMS); cellulose within cells providing rigidity; the absence of organs of locomotion; absence of nervous and sensory systems; and an alternation of haploid and diploid generations.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.RNA, Ribosomal: The most abundant form of RNA. Together with proteins, it forms the ribosomes, playing a structural role and also a role in ribosomal binding of mRNA and tRNAs. Individual chains are conventionally designated by their sedimentation coefficients. In eukaryotes, four large chains exist, synthesized in the nucleolus and constituting about 50% of the ribosome. (Dorland, 28th ed)Ribonucleases: Enzymes that catalyze the hydrolysis of ester bonds within RNA. EC 3.1.-.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)DNA, Recombinant: Biologically active DNA which has been formed by the in vitro joining of segments of DNA from different sources. It includes the recombination joint or edge of a heteroduplex region where two recombining DNA molecules are connected.Macromolecular Substances: Compounds and molecular complexes that consist of very large numbers of atoms and are generally over 500 kDa in size. In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure.Amino Acids: Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.Genetic Complementation Test: A test used to determine whether or not complementation (compensation in the form of dominance) will occur in a cell with a given mutant phenotype when another mutant genome, encoding the same mutant phenotype, is introduced into that cell.Mutagenesis, Site-Directed: Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.Protein Biosynthesis: The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS.Temperature: The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.Nucleotides: The monomeric units from which DNA or RNA polymers are constructed. They consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group. (From King & Stansfield, A Dictionary of Genetics, 4th ed)Software: Sequential operating programs and data which instruct the functioning of a digital computer.Fungal Proteins: Proteins found in any species of fungus.Retroviridae: Family of RNA viruses that infects birds and mammals and encodes the enzyme reverse transcriptase. The family contains seven genera: DELTARETROVIRUS; LENTIVIRUS; RETROVIRUSES TYPE B, MAMMALIAN; ALPHARETROVIRUS; GAMMARETROVIRUS; RETROVIRUSES TYPE D; and SPUMAVIRUS. A key feature of retrovirus biology is the synthesis of a DNA copy of the genome which is integrated into cellular DNA. After integration it is sometimes not expressed but maintained in a latent state (PROVIRUSES).HeLa Cells: The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.DNA Transposable Elements: Discrete segments of DNA which can excise and reintegrate to another site in the genome. Most are inactive, i.e., have not been found to exist outside the integrated state. DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom.Genes, Fungal: The functional hereditary units of FUNGI.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Circular Dichroism: A change from planar to elliptic polarization when an initially plane-polarized light wave traverses an optically active medium. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Recombination, Genetic: Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Amino Acid Motifs: Commonly observed structural components of proteins formed by simple combinations of adjacent secondary structures. A commonly observed structure may be composed of a CONSERVED SEQUENCE which can be represented by a CONSENSUS SEQUENCE.Sequence Analysis: A multistage process that includes the determination of a sequence (protein, carbohydrate, etc.), its fragmentation and analysis, and the interpretation of the resulting sequence information.Cross Reactions: Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.RNA-Binding Proteins: Proteins that bind to RNA molecules. Included here are RIBONUCLEOPROTEINS and other proteins whose function is to bind specifically to RNA.Sequence Analysis, Protein: A process that includes the determination of AMINO ACID SEQUENCE of a protein (or peptide, oligopeptide or peptide fragment) and the information analysis of the sequence.Aptamers, Nucleotide: Nucleotide sequences, generated by iterative rounds of SELEX APTAMER TECHNIQUE, that bind to a target molecule specifically and with high affinity.Poly A: A group of adenine ribonucleotides in which the phosphate residues of each adenine ribonucleotide act as bridges in forming diester linkages between the ribose moieties.Trypsin: A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4.Base Composition: The relative amounts of the PURINES and PYRIMIDINES in a nucleic acid.GuanineConsensus Sequence: A theoretical representative nucleotide or amino acid sequence in which each nucleotide or amino acid is the one which occurs most frequently at that site in the different sequences which occur in nature. The phrase also refers to an actual sequence which approximates the theoretical consensus. A known CONSERVED SEQUENCE set is represented by a consensus sequence. Commonly observed supersecondary protein structures (AMINO ACID MOTIFS) are often formed by conserved sequences.Chickens: Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Escherichia coli Proteins: Proteins obtained from ESCHERICHIA COLI.ComputersChromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Plant Viruses: Viruses parasitic on plants higher than bacteria.Base Pairing: Pairing of purine and pyrimidine bases by HYDROGEN BONDING in double-stranded DNA or RNA.Cyanogen Bromide: Cyanogen bromide (CNBr). A compound used in molecular biology to digest some proteins and as a coupling reagent for phosphoroamidate or pyrophosphate internucleotide bonds in DNA duplexes.Codon: A set of three nucleotides in a protein coding sequence that specifies individual amino acids or a termination signal (CODON, TERMINATOR). Most codons are universal, but some organisms do not produce the transfer RNAs (RNA, TRANSFER) complementary to all codons. These codons are referred to as unassigned codons (CODONS, NONSENSE).Nuclear Proteins: Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.Evolution, Molecular: The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.Catalysis: The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.COS Cells: CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). They are used for transfection and cloning. (The CV-1 cell line was derived from the kidney of an adult male African green monkey (CERCOPITHECUS AETHIOPS).)Genome, Viral: The complete genetic complement contained in a DNA or RNA molecule in a virus.Dimerization: The process by which two molecules of the same chemical composition form a condensation product or polymer.Operon: In bacteria, a group of metabolically related genes, with a common promoter, whose transcription into a single polycistronic MESSENGER RNA is under the control of an OPERATOR REGION.Thermodynamics: A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)Saccharomyces cerevisiae Proteins: Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.Nucleotide Mapping: Two-dimensional separation and analysis of nucleotides.Cricetinae: A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Catalytic Domain: The region of an enzyme that interacts with its substrate to cause the enzymatic reaction.Computational Biology: A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.Ligands: A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)Sequence Deletion: Deletion of sequences of nucleic acids from the genetic material of an individual.Oligoribonucleotides: A group of ribonucleotides (up to 12) in which the phosphate residues of each ribonucleotide act as bridges in forming diester linkages between the ribose moieties.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Hot Temperature: Presence of warmth or heat or a temperature notably higher than an accustomed norm.Cell Nucleus: Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Viruses: Minute infectious agents whose genomes are composed of DNA or RNA, but not both. They are characterized by a lack of independent metabolism and the inability to replicate outside living host cells.Bacteria: One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.Hydrolysis: The process of cleaving a chemical compound by the addition of a molecule of water.DNA, Fungal: Deoxyribonucleic acid that makes up the genetic material of fungi.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Mutagenesis: Process of generating a genetic MUTATION. It may occur spontaneously or be induced by MUTAGENS.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.PhosphoproteinsRNA Probes: RNA, usually prepared by transcription from cloned DNA, which complements a specific mRNA or DNA and is generally used for studies of virus genes, distribution of specific RNA in tissues and cells, integration of viral DNA into genomes, transcription, etc. Whereas DNA PROBES are preferred for use at a more macroscopic level for detection of the presence of DNA/RNA from specific species or subspecies, RNA probes are preferred for genetic studies. Conventional labels for the RNA probe include radioisotope labels 32P and 125I and the chemical label biotin. RNA probes may be further divided by category into plus-sense RNA probes, minus-sense RNA probes, and antisense RNA probes.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Oligonucleotides, Antisense: Short fragments of DNA or RNA that are used to alter the function of target RNAs or DNAs to which they hybridize.Polyribonucleotides: A group of 13 or more ribonucleotides in which the phosphate residues of each ribonucleotide act as bridges in forming diester linkages between the ribose moieties.RNA, Transfer: The small RNA molecules, 73-80 nucleotides long, that function during translation (TRANSLATION, GENETIC) to align AMINO ACIDS at the RIBOSOMES in a sequence determined by the mRNA (RNA, MESSENGER). There are about 30 different transfer RNAs. Each recognizes a specific CODON set on the mRNA through its own ANTICODON and as aminoacyl tRNAs (RNA, TRANSFER, AMINO ACYL), each carries a specific amino acid to the ribosome to add to the elongating peptide chains.PolynucleotidesDNA, Catalytic: Molecules of DNA that possess enzymatic activity.Tissue Distribution: Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.In Situ Hybridization: A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.Chemistry: A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.Organ Specificity: Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.Drosophila melanogaster: A species of fruit fly much used in genetics because of the large size of its chromosomes.Bacteriophages: Viruses whose hosts are bacterial cells.G-Quadruplexes: Higher-order DNA and RNA structures formed from guanine-rich sequences. They are formed around a core of at least 2 stacked tetrads of hydrogen-bonded GUANINE bases. They can be formed from one two or four separate strands of DNA (or RNA) and can display a wide variety of topologies, which are a consequence of various combinations of strand direction, length, and sequence. (From Nucleic Acids Res. 2006;34(19):5402-15)Hydrogen Bonding: A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Models, Chemical: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.Electrophoresis, Agar Gel: Electrophoresis in which agar or agarose gel is used as the diffusion medium.Microscopy, Electron: Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.Fluorescent Dyes: Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Introns: Sequences of DNA in the genes that are located between the EXONS. They are transcribed along with the exons but are removed from the primary gene transcript by RNA SPLICING to leave mature RNA. Some introns code for separate genes.Chemical Phenomena: The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.RNA, Double-Stranded: RNA consisting of two strands as opposed to the more prevalent single-stranded RNA. Most of the double-stranded segments are formed from transcription of DNA by intramolecular base-pairing of inverted complementary sequences separated by a single-stranded loop. Some double-stranded segments of RNA are normal in all organisms.RNA-Directed DNA Polymerase: An enzyme that synthesizes DNA on an RNA template. It is encoded by the pol gene of retroviruses and by certain retrovirus-like elements. EC 2.7.7.49.Intercalating Agents: Agents that are capable of inserting themselves between the successive bases in DNA, thus kinking, uncoiling or otherwise deforming it and therefore preventing its proper functioning. They are used in the study of DNA.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Endopeptidases: A subclass of PEPTIDE HYDROLASES that catalyze the internal cleavage of PEPTIDES or PROTEINS.Spectrophotometry, Ultraviolet: Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Genomic Library: A form of GENE LIBRARY containing the complete DNA sequences present in the genome of a given organism. It contrasts with a cDNA library which contains only sequences utilized in protein coding (lacking introns).Molecular Diagnostic Techniques: MOLECULAR BIOLOGY techniques used in the diagnosis of disease.Gene Expression Regulation, Bacterial: Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.Nucleosides: Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King & Stansfield, A Dictionary of Genetics, 4th ed)RNA Viruses: Viruses whose genetic material is RNA.Protein Folding: Processes involved in the formation of TERTIARY PROTEIN STRUCTURE.DNA, Ribosomal: DNA sequences encoding RIBOSOMAL RNA and the segments of DNA separating the individual ribosomal RNA genes, referred to as RIBOSOMAL SPACER DNA.Bacillus subtilis: A species of gram-positive bacteria that is a common soil and water saprophyte.Databases, Nucleic Acid: Databases containing information about NUCLEIC ACIDS such as BASE SEQUENCE; SNPS; NUCLEIC ACID CONFORMATION; and other properties. Information about the DNA fragments kept in a GENE LIBRARY or GENOMIC LIBRARY is often maintained in DNA databases.Glycoproteins: Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.Genes, Regulator: Genes which regulate or circumscribe the activity of other genes; specifically, genes which code for PROTEINS or RNAs which have GENE EXPRESSION REGULATION functions.Serine Endopeptidases: Any member of the group of ENDOPEPTIDASES containing at the active site a serine residue involved in catalysis.Exons: The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA.Swine: Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).Immobilized Nucleic Acids: DNA or RNA bound to a substrate thereby having fixed positions.Blood Proteins: Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.Epitopes: Sites on an antigen that interact with specific antibodies.

*  The crystal structure of APOBEC-2 and implications for APOBEC enzymes ::...
Extensive sequence homology among APOBEC family members allows us to test Apo2 structure-based ... by the lack of 3-dimensional structures of APOBEC proteins that deaminate large nucleic acid ... which deaminate free cytidine/cytosine bases which share considerable sequence homology with ... family of cytidine deaminases that modify genes by deaminating cytosines in mRNA coding sequences ......
http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/39667/rec/20
*  http://ufdc.ufl.edu/UFE0022901/00001
Nucleic Acids Res. 26, 2050-2057. Schwer, B., Shuman, S., 2006. Ge netic analysis of poxvirus mR NA ... Homology between RNA polymerases of poxviruses, prokaryotes, and eukaryotes: nucleotide sequence ... The vaccinia virus D5 protein, which is required for DNA replication, is a nucleic acid-independent ... The sequence of D1R in the WR strain was found to be identical to the previously published sequence ......
http://ufdc.ufl.edu/UFE0022901/00001
*  Overexpression of activin A in stage IV colorectal cancer | Gut
... amino acid sequence homology whereas inhibin α shares 27% and 23% amino acid homology with inhibin ... The Genius 3 non-radioactive nucleic acid detection kit was used for immunological detection.28-31 ... Each composite primer had the target gene primer sequence attached to a short stretch of sequence ... Genius 3 non-radioactive nucleic acid detection kit, and Genius 4 RNA and random primed labelling ......
http://gut.bmj.com/content/49/3/409
*  Plus it
TEM7R EST sequences were identified by homology to TEM7 using tBLASTn of the National Center for ... DIG Nucleic Acid Detection kit) containing purified, nonspecific rabbit immunoglobulins (DAKO). For ... 1) ⇓ . In addition, amino acids 164-230 bear weak homology to a Sushi/SCR/CCP domain. ... 1) ⇓ . The 300-amino acid region containing the LRRs shares homology with the membrane glycoprotein ......
http://cancerres.aacrjournals.org/content/61/18/6649
*  Domain assignment for YHR214C-B from Saccharomyces cerevisiae SGD
nucleic acid binding transcription factor activity. 1.532. 7.01. Protein sequence. External link(s) ... "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent ... Identical sequences. O13535 4932.YHR214C-B YR154 YHR214C-B YHR214C-B YHR214C-B ... Sequence length. 1793. Comment. YHR214C-B SGDID:S000003534, Chr VIII from 549346-547931,547929- ......
http://supfam.org/SUPERFAMILY/cgi-bin/gene.cgi?genome=sc&seqid=YHR214C-B
*  Domain assignment for YDR034C-D from Saccharomyces cerevisiae SGD
nucleic acid binding transcription factor activity. 1.532. 7.01. Protein sequence. External link(s) ... "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent ... Identical sequences. Q12472 YDR034C-D 4932.YDR034C-D YR114 YDR034C-D YDR034C-D ... Sequence length. 1770. Comment. YDR034C-D SGDID:S000007345, Chr IV from 519354-518062,518060-514041 ......
http://supfam.org/SUPERFAMILY/cgi-bin/gene.cgi?genome=sc&seqid=YDR034C-D
*  The 13-kD FK506 Binding Protein, FKBP13, Interacts with a Novel Homologue of...
... and then DNA sequenced. The plasmid encoded a 129-amino acid (aa) peptide with sequence homology to ... nucleic acid identity (7, 56). ... amino acid(s). ala. alanine. arg. arginine. β-gal ... as the query sequence (47). Mouse expressed sequence tag (EST) clone with EMBL/GenBank/DDBJ ... expressed sequence tag. FKBP. FK506 binding protein. GAL4(DB). GAL4 DNA-binding domain. GAL4(TA). ......
http://jcb.rupress.org/content/141/1/143
*  Anti-BetaGamma (MPS-Phosducin-like protein C terminus) - ANA24177 - 0.5 mg -...
The PhLP shares amino acid sequence homology with phosphoducin, a phosphoprotein expressed in the ... Nucleic Acid Stains * Protein Stains * Blood Products * Instruments & Consumables * Automated Cell ... This is a membrane-permeable phosphoducin-like anti-βγ peptide, whose membrane-permeable sequence ( ......
http://bioscience.co.uk/product~58285
*  Getting The Mooney Treatment - The Loom
... amino acids, nucleic acids, sugars, etc) floating around and the first bacteria. ... No necessary signs of evolution such as homologies or excaptations had been detected. Too late now. ... Humans have four parallel sequences of very similar Hox genes as they are more complex organisms. ... From consistent and clear evidence that is provided by gene sequencing, it is found that particular ......
http://scienceblogs.com/loom/2006/11/13/getting-the-mooney-treatment/
*  Cheap and Free Domain Name Registration
... DEDICATED SERVERS When you want to smoke the competition, GlowHost Managed Dedicated Servers are how you get it done. Cheap and Free Domain Name Registration. Web Hosting Features Domain Name Registration. Cheap and Free Domain Name Registration Cheap Domain Registration from $1.99. Get your domain registration from as little as $1.99 when you order any non-domain product from our domain registration partner, InstaPro.net. FREE Domain Name Registration. More about free domain names ... GlowHost Domain Name Registration Services. Get your FREE Domain now. Why are you giving away free domain names. We believe that if you choose GlowHost as your web hosting provider, you will be so happy with the features and service that we provide, that you will have no reason to switch to another provider for your hosting and domain name needs. Learn more about free domain names. Bulk Domain Name Registration Bulk domain name registration is right for individuals who want to register 2 or more domains at a time. Bulk Dom...
https://glowhost.com/web-hosting-features/domain_registration.html
*  A1 domain
a domain a domain redirect list of a genes proteins or receptors...
https://en.wikipedia.org/wiki/A1_domain
*  Molecules | Free Full-Text | Chiral Peptide Nucleic Acids with a Substituent in the N-(2-Aminoethy)g
Chiral Peptide Nucleic Acids with a Substituent in the N- 2-Aminoethy glycine Backbone. Previous Article in Journal Unexpected Behavior of Enaminones: Interesting New Routes to 1,6-Naphthyridines, 2-Oxopyrrolidines and Pyrano naphthyridines Previous Article in Special Issue Oxime-Based Carbonates as Useful Reagents for Both N- Protection and Peptide Coupling. all Erratum Addendum Article Book Review Case Report Comment Commentary Communication Concept Paper Conference Report Correction Creative Data Descriptor Discussion Editorial Essay Interesting Images Letter New Book Received Obituary Opinion Project Report Reply Retraction Review Short Note Technical Note Special Issue. Molecules 2013, 18 1, 287-310; doi: 10.3390/molecules18010287 Review Chiral Peptide Nucleic Acids with a Substituent in the N - 2-Aminoethy glycine Backbone Toru Sugiyama 1, *. 1 Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Meguro-ku, Tokyo 153-8902, Japan. Received: 14 December 2012 ...
http://mdpi.com/1420-3049/18/1/287
*  A rapid coupling protocol for the synthesis of peptide nucleic acids | Swinburne Research Bank
A rapid coupling protocol for the synthesis of peptide nucleic acids. Swinburne Research Bank. Please be patient while the object screen loads. Faculties TAFE. Current Students. My.Swinburne. Search. Study at Swinburne. Business Industry. Swinburne Research Bank. Copyright. Contact. Search Swinburne Research Bank. All items Advanced Search. 1101 Medical Biochemistry and Metabolomics. List of Titles A rapid coupling protocol for the synthesis of peptide nucleic acids. Title A rapid coupling protocol for the synthesis of peptide nucleic acids Author s. Abstract With the current interest in anti-sense and anti-gene technologies, an efficient, fast and less toxic synthesis protocol would be advantageous for the oligomerisation of Peptide Nucleic Acids PNA. In this work, a rapid synthesis protocol has been adapted from an earlier published peptide synthesis method allowing a reduction in cycle time from around 30 min down to 16 min. By utilising quantitative deprotection with 100% TFA, a coupling time of 10 min an...
http://researchbank.swinburne.edu.au/vital/access/manager/Repository/swin:15264?exact=subject.for:"0601 Biochemistry and Cell Biology"&f0=subject:"1101 Medical Biochemistry and Metabolomics"
*  P E Nielsen
2007 Antisense peptide nucleic acids P E Nielsen Center for Biomolecular Recognition, Department for Biochemistry and Genetics, Laboratory B, The Panum Institute, Blegdamsvej 3C, DK 2200 N Copenhagen, Denmark Curr Opin Mol Ther 2:282-7. 2000 Targeting double stranded DNA with peptide nucleic acid PNA P E Nielsen Center for Biomolecular Recognition, Department of Medical Biochemistry and Genetics, The Panum Institute, Blegdamsvej 3, Copenhagen N, DK 2200, Denmark Curr Med Chem 8:545-50. Antisense peptide nucleic acids P E Nielsen Center for Biomolecular Recognition, Department for Biochemistry and Genetics, Laboratory B, The Panum Institute, Blegdamsvej 3C, DK 2200 N Copenhagen, Denmark Curr Opin Mol Ther 2:282-7. Targeting double stranded DNA with peptide nucleic acid PNA P E Nielsen Center for Biomolecular Recognition, Department of Medical Biochemistry and Genetics, The Panum Institute, Blegdamsvej 3, Copenhagen N, DK 2200, Denmark Curr Med Chem 8:545-50. Combined triplex/duplex invasion of double-stranded ...
http://labome.org/expert/denmark/university/nielsen/p-e-nielsen-174352.html
*  Peptide nucleic acid combinatorial libraries and improved methods of synthesis - Isis Pharmaceutical
A method of adding further random peptide nucleic acid units to an amine terminated peptide nucleic acid oligomer on a solid phase synthesis resin comprising the steps of: a treating said amine terminated oligomer on said solid phase synthesis resin with a bifunctional acetyl synthon to react a first reactive site of said bifunctional acetyl synthon with said terminal amine of said oligomer to form a resin bound oligomer having a monofunctional acetyl moiety thereon; b selecting an alkyldiamine synthon having the first of its amino functional groups in the form of a protected amino group and the other of its amino functions groups as a free amine; c treating said resin bound oligomer having said monofunctional acetyl moiety thereon with said alkyldiamine synthon to covalently bond said acetyl moiety and said free amine group of said alkyldiamine synthon forming a resin bound oligomer having an extension thereon where said extension includes a secondary amine and a protected amino group; d dividing said resin ...
http://freepatentsonline.com/5539083.html
*  Peptide nucleic acid
... 'Peptide nucleic acid' 'PNA' is an artificially synthesized polymer similar to DNA or RNA invented by Peter E. Due to their higher binding strength it is not necessary to design long PNA oligomers for use in these roles, which usually require oligonucleotide probes of 20–25 bases. PNA oligomers also show greater specificity in binding to complementary DNAs, with a PNA/DNA base mismatch being more destabilizing than a similar mismatch in a DNA/DNA duplex. Structure PNA binding Delivery PNA world hypothesis Applications See also References Further reading. DNA and RNA have a deoxyribose and ribose sugar backbone, respectively, whereas PNA's backbone is composed of repeating N- 2-aminoethyl -glycine units linked by peptide bond s. PNAs are depicted like peptide s, with the N -terminus at the first left position and the C -terminus at the last right position. 2 PNA binding. Since the backbone of PNA contains no charged phosphate groups, the binding between PNA/DNA strands is stronger than between DNA/DNA str...
https://en.wikipedia.org/wiki/Peptide_nucleic_acid
*  Peptide Nucleic Acids Modified Nano-Biosensor for Early Cancer Diagnosis
... Technical Conferences. Business Conferences. Nano Impact Workshop. Venue / Hotels. Nanotech 2007 Home Program. Sessions. Sunday. Monday. Tuesday. Wednesday. Thursday. Index of Authors. Index of Keywords. Confirmed Speakers. Conferences Symposia. Expo / Sponsors. Sponsors. Media Sponsors. 2007 NSTI Nanotechnology Conference and Trade Show - Nanotech 2007 - 10 th Annual. Program At-a-Glance Sessions Sunday Monday Tuesday Wednesday Thursday Index of Authors Index of Keywords Confirmed Speakers Conferences Symposia. Peptide Nucleic Acids Modified Nano-Biosensor for Early Cancer Diagnosis. Keywords: PNA synthesis, DNA methylation, nano-biosensor, cancer detection. DNA methylation is one of two epigenetic alterations. A distinct set of tumor types has a high level of hypermethylation in the promoter region of tumor suppressor genes. The analysis of the promoter methylation status will be one of the promising strategies for cancer early diagnosis. In order to make robust biosensor surface, we synthesized PNA se...
http://nsti.org/Nanotech2007/showabstract.html?absno=177
*  Search Results
Journals Artificial DNA, PNA XNA 64 less. Sugiyama, Hiroshi Artificial DNA, PNA & XNA 2014;5:e28226. Rozners, Eriks Artificial DNA, PNA & XNA 2013;4 3 :69-76. doi:10.4161/adna.26599 PMCID: PMC3962516 PMID: 24104925 PNA backbone modification; PNA-RNA triple helix; isothermal titration calorimetry; peptide nucleic acid; recognition of double-stranded RNA Related Articles. Artificial DNA, PNA & XNA 2013;4 2 :35-36. doi:10.4161/adna.24680 PMCID: PMC3771995 PMID: 23603781. O’ Driscoll, Aisling Artificial DNA, PNA & XNA 2013;4 2 :37-38. doi:10.4161/adna.25489 PMCID: PMC3771996 PMID: 23912716 synthetic DNA; diagnostics; information; storage; identification Related Articles. Obika, Satoshi Artificial DNA, PNA & XNA 2013;4 2 :39-48. doi:10.4161/adna.25786 PMCID: PMC3771997 PMID: 24044051 2′,4′-BNA/LNA; KODDNA polymerase; Bridged locked nucleic acid aptamer; Capillary electrophoresis-systematic evolution of ligands by exponential enrichment CE-SELEX ; Xeno-nucleic acid XNA Related Articles. Artificial DNA, PNA & XNA 20...
http://pubmedcentralcanada.ca/pmcc/solr/reg?pageSize=25&term=issn:1949-0968&sortby=score desc
*  Patent US6469151 - PNA-DNA chimeric probe arrays and methods of use - Google Patents
... Search Images Maps Play YouTube News Gmail Drive. More. Sign in. Advanced Patent Search. Patents. The invention provides methods, kits, and compositions for ligation of PNA-DNA chimeric probes and oligonucleotides when they are hybridized adjacently to template nucleic acids using ligases and ligation reagents. Structural requirements of the chimeras for ligation include 5 to 15 contiguous PNA monomer... http://www.google.com.au/patents/US6469151?utm source=gb-gplus-share Patent US6469151 - PNA-DNA chimeric probe arrays and methods of use Advanced Patent Search Publication number US6469151 B1. Publication type Grant. Application number US 09/881,557. Publication date 22 Oct 2002. Filing date 14 Jun 2001. Priority date 8 Oct 1999. Fee status Paid. Also published as CA2353801A1,. DE60016947D1,. DE60016947T2,. EP1220953A2,. EP1220953B1,. US6297016,. US20020177133,. WO2001027326A2,. WO2001027326A3. Publication number 09881557, 881557, US 6469151 B1, US 6469151B1, US-B1-6469151, US6469151 B1, US6469151B1. Inv...
http://google.com.au/patents/US6469151?ie=ISO-8859-1
*  RNA targeting with peptide conjugates of oligonucleotides, siRNA and PNA.
... MedLine Citation:. Towards the development of oligonucleotide analogues and siRNA as drugs, one potential alternative to the use of liposomal transfection agents is the covalent conjugation of a cell-penetrating peptide CPP , with the intention of imparting on the oligonucleotide or siRNA an enhanced ability to enter mammalian cells and reach the appropriate RNA target. We have developed robust methods for the chemical synthesis of disulfide-linked conjugates of oligonucleotide analogues, siRNA and peptide nucleic acids PNA with a range of cationic and other CPPs. In a HeLa cell assay with integrated plasmid reporters of Tat-dependent trans-activation at the TAR RNA target in the cell nucleus, we were unable to obtain steric block inhibition of gene expression for conjugates of CPPs with a 12-mer oligonucleotide mixmer of 2'-O-methyl and locked nucleic acids units. By contrast, we were able to obtain some reductions in expression of P38alpha MAP kinase mRNA in HeLa cells using microM concentrations of Pe...
http://biomedsearch.com/nih/RNA-targeting-with-peptide-conjugates/17113327.html
*  NIF | Searching in Literature
NIF. Searching in Literature. SciCrunch relies heavily on JavaScript. Many functions on the site will not work if you continue with JavaScript disabled. Login. Register. NIF LinkOut Portal. About. Add a Resource. Literature. Go. X. Sign In. Log In. X Forgot Password. If you have forgotten your password you can enter your email here and get a temporary password sent to your email. Send. X. Leaving Community. Are you sure you want to leave this community. Leaving the community will revoke any permissions you have been granted in this community. No. Yes. Literature. Home Literature. Nanoparticle-based therapy in an in vivo microRNA-155 miR-155 -dependent mouse model of lymphoma. MicroRNA-155 miR-155 is an oncogenic microRNA that regulates several pathways involved in cell division and immunoregulation. It is overexpressed in numerous cancers, is often correlated with poor prognosis, and is thus a key target for future therapies. In this work we show that overexpression of miR-155 in lymphoid tissues results in d...
https://scicrunch.org/22685206/resource/nif-0000-34000
*  Synthese modifizierter Peptidnukleinsäuren und deren Anwendung zur DNA-Analyse - heiDOK
Boll, Iris English Title: Synthesis of modified peptide nucleic acids and their application for DNA analysis. In dieser Arbeit wurde die katalytische Hydrolyse einer Ester-PNA durch ein Cu2+-Komplex-PNA-Konjugat untersucht, die sowohl durch Einzelstrang-DNA als auch durch Doppelstrang-DNA gesteuert werden kann. Translation of abstract English Within this study metal complex functionalized peptide nucleic acids und internally modified peptide nucleic acids were synthesized and their reactions on DNA templates have been investigated. In this study a reaction of catalytic ester-PNA hydrolysis by Cu II complex-PNA conjugates, which is triggered by single-stranded DNA as well as double-stranded DNA as templates, has been investigated. The hydrolysis of an ester-PNA on a single-stranded DNA template catalysed by a copper complex of a catalyst-PNA provides 100 fold kinetic discrimination between DNAs, which are different from each other only at a single nucleotide position. In the presence of a double-stranded DNA t...
http://archiv.ub.uni-heidelberg.de/volltextserver/5738/
*  publications-ttakahashi
18.Takahashi T, Ueno A, Mihara H.: Nucleobase amino acids incorporated into the HIV-1 nucleocapsid protein increased the binding affinity and specificity for a hairpin RNA. 19.Takahashi T, Hamasaki K, Ueno A, Mihara H.: Construction of peptides with nucleobase amino acids: design and synthesis of the nucleobase-conjugated peptides derived from HIV-1 Rev and their binding properties to HIV-1 RRE RNA. 20.Balasundaram G, Takahashi T, Ueno A, Mihara H.: Construction of peptide conjugates with peptide nucleic acids containing an anthracene probe and their interactions with DNA. 21.Kumagai I, Takahashi T, Hamasaki K, Ueno A, Mihara H.: HIV-1 Rev peptides conjugated with peptide nucleic acids and their efficient binding to RRE RNA. 22.Takahashi T, Hamasaki K, Kumagai I, Ueno A, Mihara H.: Design of a nucleobase-conjugated peptide that recognizes HIV-1 RRE IIB RNA with high affinity and specificity. 24.Kumagai I, Takahashi T, Hamasaki K, Ueno A, Mihara H.: Construction of HIV Rev peptides containing peptide nucleic a...
http://asrldu.dept.med.gunma-u.ac.jp/ttakahashi/publications-ttakahashi.html
*  IJMS | Free Full-Text | RNA Interference in Mammalia Cells by RNA-3’-PNA Chimeras | HTML
Keywords: modified siRNA; RNA interference; RNA-PNA chimeras; Peptide Nucleic Acids; RNA. Peptide Nucleic Acids PNAs are oligonucleotide mimics in which the sugar-phosphate backbone has been replaced by a pseudo-peptide backbone. In the present work, we report the synthesis of siRNAs composed of RNA-PNA chimeras, their chemical-physical characterization and the evaluation of their gene silencing activity in cultured mammalian cells, based on their ability to target the firefly luciferase mRNA. Then, the oligomers were combined to form siRNAs in the four possible combinations Table 1 : siRNA A, with unmodified sense and antisense strands; siRNA B, with modified sense strand and unmodified antisense strand; siRNA C, with unmodified sense strand and modified antisense strand; siRNA D, with modified sense and antisense strands. 2.2 Compatibility of RNA-3’-PNA chimeras with the siRNA machinery To verify the compatibility of PNA units into siRNA with the RNAi machinery, we have evaluated the different siRNAs for th...
http://mdpi.com/1422-0067/9/3/299/htm
*  Synthese modifizierter Oligonucleotid-Sonden für den DNA-Nachweis durch katalytische Signalamplif
... ikation - heiDOK. Synthese modifizierter Oligonucleotid-Sonden für den DNA-Nachweis durch katalytische Signalamplifikation. Graf, Nora Julie Charlotte English Title: Synthesis of Modified Oligonucleotide Probes for DNA Detection by Catalytic Signal Amplification. Abstract Die Arbeit behandelt die Synthese Metallkomplex-funktionalisierter Oligonucleotide und Peptidnucleinsäuren PNAs und deren Anwendung als Sonden für den sequenzspezifischen DNA-Nachweis. Für die Nachweisreaktionen, die auf Signalverstärkung beruhen, wurden Konjugate von DNA-Oligonucleotiden mit Metallkomplexen synthetisiert, die bei Hybridisierung mit komplementärer DNA das Metallion CuII, ZnII freisetzen. Das CuII-Ion bzw. Translation of abstract English The thesis covers the synthesis of metal complex functionalized oligonucleotides and peptide nucleic acids PNA and their application for DNA sequence detection, including both metal catalysis on DNA templates and signal cascades with chemical or enzymatic amplification. A nucleic acid tem...
http://archiv.ub.uni-heidelberg.de/volltextserver/6945/
*  Research Resource
... Resource. Programmable self-assembled nanostructures based on sidechain-modified pna for the multivalent display of ligands U.S. Patent Number EP 2569328 A2. Share External Link Disclaimer. Acronym: Not Available. NIDDK Contact:. tao@niddk.nih.gov. Principal Investigator s :. Daniel Appella. Resource Link:. http://www.google.com/patents/EP2569328A2?cl=en. Description:. The invention concerns compositions comprising strands of polynucleotide and strands of PNA, each PNA strand comprising:. i from 2 to 50 nucleobase subunits and. ii one or more gamma substituents. The PNA strands are complementary to at least a portion of at least some of the polynucleotide strands, and the molar ratio of PNA strands to polynucleotide strands being at least 1:1. Certain gamma substituents are capable of effecting attachment of a PNA strand to a cell. The invention also concerns construction of nanostructure platforms and vaccines and use of the inventive compositions in inhibiting disease states in mammals. Click outside o...
http://niddk.nih.gov/pages/RRSplash.aspx?ID=355
*  Xeno nucleic acid
... 'Xeno nucleic acid XNA ' is a synthetic alternative to the natural nucleic acids DNA and RNA as information-storing biopolymer s that differs in the sugar backbone. 1 As of 2011, at least six types of synthetic sugars have been shown to form nucleic acid backbones that can store and retrieve genetic information. Thus the genetic information stored in XNA is “invisible” and therefore useless to natural DNA-based organisms. 2 Background Structure Implications Applications See also References. Now, two of the leading teams studying XNA, synthetic biology professors Philipp Holliger and Vitor Pinheiro, both from the University of Cambridge, managed to create the XNA equivalent of a Ribozyme, enzymes made of DNA or ribonucleic acid; This demonstrates that XNAs not only store hereditary information, but can also serve as enzymes, raising the possibility that life elsewhere could have began with something other than RNA or DNA. A nucleotide is made up of three chemical components: a phosphate, a five-carbon sug...
https://en.wikipedia.org/wiki/Xeno_nucleic_acid
*  Publications - 1999 | Gellman Research Group
Publications - 1999. Gellman Research Group. Skip to main content. Home Research Publications Group Members. Alumni. Publications - 1999. All. 1989. 1990. 1991. 1992. 1993. 1994. 1995. 1996. 1997. 1998. 1999. 2000. 2001. 2002. 2003. 2004. 2005. 2006. 2007. 2008. 2009. 2010. 2011. 2012. 2013. 2014. 2015. 76 "NMR-Based Quantification of β -Sheet Populations in Aqueous Solution Through Use of Reference Peptides for the Folded and Unfolded States," F. A Syud, J. F Espinosa and S. H Gellman J. Am. Chem. Soc. 1999, 121, 11577. . 75 "Non-Hydrogen Bonded Secondary Structures in β -Peptides: Evidence from Circular Dichroism of S -Pyrrolidine-3-Carboxylic Acid Oligomers and S -Nipecotic Acid Oligomers," B. R Huck, J. R Langenhan and S. H Gellman Org. Lett. 1999, 1, 1717. . 74 "Synthesis and Characterization of Helix-Forming β -Peptides: trans -2-aminocyclopentanecarboxylic acid oligomers," D. H Appella, L. A Christianson, D. A Klein, M. R Richards, D. R Powell and S. H Gellman J. Am. Chem. Soc. 1999, 121, 7574. 73 "Syn...
http://gellman.chem.wisc.edu/publications/1999
*  Glycol nucleic acid
... ' Glycol nucleic acid' GNA is a polymer similar to DNA or RNA but differing in the composition of its "backbone". GNA is not known to occur naturally; they are synthesized chemically. The 2,3-dihydroxypropylnucleoside analogues were first prepared by Ueda et al. Soon thereafter it was shown that phosphate-linked oligomers of the analogues do in fact exhibit hypochromicity in the presence of RNA and DNA in solution Seita et al. The preparation of the polymers was later described by Cook et al. 1995, 1999 and Acevedo and Andrews 1996. The GNA-GNA self-pairing described by Zhang and Meggers is however novel, and the specificity of interaction well-demonstrated. DNA and RNA have a deoxyribose and ribose sugar backbone, respectively, whereas GNA's backbone is composed of repeating glycol units linked by phosphodiester bond s. The glycol unit has just three carbon atoms and still shows Watson-Crick base pairing. The Watson-Crick base pairing is much more stable in GNA than its natural counterparts DNA and RNA ...
https://en.wikipedia.org/wiki/Glycol_nucleic_acid
*  Chemical Candidate to Carry Genetic Information in Earliest Life | Answers in Genesis
Chemical Candidate to Carry Genetic Information in Earliest Life. Answers in Genesis. Answers in Genesis. Science. Chemical Candidate to Carry Genetic Information in Earliest Life Forms. Chemical Candidate to Carry Genetic Information in Earliest Life Forms. Science Daily : “ Scientists Discover Possible Building Blocks of Ancient Genetic Systems in Earth's Most Primitive Organisms ” Evolutionary scientists suggest a simple chemical candidate to carry genetic information in the earliest life forms. Evolutionists hypothesize that before DNA evolved, RNA did the job of coding and duplicating information as well as directing construction of simple life forms. “Before RNA-based organisms arose, peptide nucleic acids may have been used to transmit genetic information by the earliest forms of life on earth,” 1 writes a team of American and Swedish scientists who have discovered a potential building block for PNAs in cyanobacteria. This simple molecular building block AEG could hypothetically polymerize to form a co...
https://answersingenesis.org/chemistry/chemical-candidate-carry-genetic-information/
*  Oligomer
2 Dimers, trimers, and tetramer s are, for instance, oligomers composed of two, three and four monomers, respectively. In the context of biochemistry, an oligomer usually refers to a macromolecular complex formed by non-covalent bonding of a few macromolecules like proteins or nucleic acids. In this sense, a homo-oligomer would be formed by few identical molecules and by contrast, a hetero-oligomer would be made of more than one, different, macromolecules. Collagen is an example of a homo-oligomeric protein that is composed of three identical protein chains. In biochemistry, the term oligonucleotide – or, informally, "oligo" - is used for short, single-stranded nucleic acid fragments, such as DNA or RNA, or similar fragments of analogs of nucleic acids such as peptide nucleic acid or Morpholino s. 5 When an oligomer forms as a result of chain transfer the oligomer is called a ' telomer ' and the process telomerization. {{Quote box |title = IUPAC definition |quote = 'Oligomer molecule': A molecule of intermedi...
https://en.wikipedia.org/wiki/Oligomer
*  Nucleic Acids ( Read ) | Biology | CK-12 Foundation
Nucleic Acids Read. Biology. CK-12 Foundation meta http-equiv="refresh" content="1; url=/nojavascript/". iframe src="//www.googletagmanager.com/ns.html?id=GTM-WVB47G" height="0" width="0" style="display:none;visibility:hidden" /iframe. Donate. Help. Join. Sign In. Library. Help. Donate. Join. Sign In. Nucleic Acids. Examples: DNA, RNA. Progress. Practice Nucleic Acids Practice. Progress. 0% Practice Now. Biology. Video. Web Links. Real World. Web Links. Real World. Share to Groups. Details. Resources. Published. Nucleic Acids. Nucleic acids. Deoxyribo nucleic acid, or DNA, is the unique blueprints to make the proteins that give you your traits. Half of these blueprints come from your mother, and half from your father. Therefore, every person that has ever lived - except for identical twins - has his or her own unique set of blueprints - or instructions - or DNA. Nucleic Acids A nucleic acid is an organic compound, such as DNA or RNA, that is built of small units called nucleotides. Structure of Nucleic Acids ...
http://ck12.org/biology/Nucleic-Acids/lesson/user:YmFzdGFwcGVyZmVubmVAd3NmY3MuazEyLm5jLnVz/Nucleic-Acids/r1/
*  Panasonic 14mm F2.5 review data at various sites.: Micro Four Thirds Talk Forum: Digital Photography
... Review. Reviews. Sample Images. Videos. Lenses. Forums. Forum index. Micro Four Thirds Talk Change forum Panasonic 14mm F2.5 review data at various sites. Shop cameras lenses ▾. Forum Parent First Previous Next Next unread. jericho77. Panasonic 14mm F2.5 review data at various sites. Aug 5, 2013. Reply to thread Reply with quote. Forum Parent First Previous Next Next unread. Posted by When Panasonic 14mm F2.5 review data at various sites. jericho77. Aug 5, 2013. Re: Panasonic 14mm F2.5 review data at various sites. Aug 5, 2013 3. Re: Panasonic 14mm F2.5 review data at various sites. Aug 5, 2013. Re: Panasonic 14mm F2.5 review data at various sites. Aug 5, 2013. Re: Panasonic 14mm F2.5 review data at various sites. jericho77. Aug 5, 2013. Aug 5, 2013. jericho77. Aug 5, 2013. Re: Panasonic 14mm F2.5 review data at various sites. jericho77. Aug 5, 2013. Re: Panasonic 14mm F2.5 review data at various sites. Aug 5, 2013 1. Re: Panasonic 14mm F2.5 review data at various sites. Alumna Gorp. Aug 5, 2013. ...
http://dpreview.com/forums/post/51930238
*  The genetic basis of a plant-insect coevolutionary key innovation. Proc Natl Acad Sci USA (PDF Downl
Proc Natl Acad Sci USA PDF Download Available. Proc Natl Acad Sci USA. © 2007 by The National Academy of Sciences of the USA www.pnas.org?cgi?doi?10.1073?pnas.0706229104PNAS. fossil calibrated, Bayesian relaxed molecular clock estimation of the Pierinae–Coliadinae divergence. Fossil and molecular data agree that the Brassicales appeared by 90 to 85 Mya, which is much earlier than the parallel evolution of glucosinolates in the Euphorbiaceae 58 Mya 28. In this article, we directly address the timing of the appearance of the glucosinolate-feeding Pierinae, using several independent molecular datasets and various calibration methods to generate a robust estimate of when Pieridae evolved relative to their Brassicales host plants. Pieridae-specific temporal reconstruction used a Bayesian relaxed molecular clock method on EF-1. Current and expected diversity, and divergence estimates for the Coliadinae and Pierinae subfamilies of Pieridae. However, there are significantly more species of Pierinae than expected, eve...
http://researchgate.net/publication/5771953_The_genetic_basis_of_a_plant-insect_coevolutionary_key_innovation._Proc_Natl_Acad_Sci_USA
*  Mystery of bacterial growth and resistance solved: Findings shed light on how bacteria form protecti
... ve biofilms -- ScienceDaily. Your source for the latest research news. Mystery of bacterial growth and resistance solved: Findings shed light on how bacteria form protective biofilms. Date: April 26, 2012 Source: The Scripps Research Institute Summary: Scientists have unraveled a complex chemical pathway that enables bacteria to form clusters called biofilms. Scientists at The Scripps Research Institute have unraveled a complex chemical pathway that enables bacteria to form clusters called biofilms. Past research had also revealed that nitric oxide is involved in influencing bacterial biofilm formation. Nitric Oxide Modulates Bacterial Biofilm Formation through a Multicomponent Cyclic-di-GMP Signaling Network. The Scripps Research Institute. "Mystery of bacterial growth and resistance solved: Findings shed light on how bacteria form protective biofilms." ScienceDaily. The Scripps Research Institute. Mystery of bacterial growth and resistance solved: Findings shed light on how bacteria form protective biof...
http://sciencedaily.com/releases/2012/04/120426135128.htm
*  Mankin Lab - Publications
Browse by year: 2014    2013    2012    2011    2010    2009    2008    2007    2006    2005    2004    2003    2002    2001    2000    1999    1998    1997    1996    1995   . Proc Natl Acad Sci USA 111, 9804-9809. 2014 The general mode of translation inhibition by macrolide antibiotics Proc Natl Acad Sci USA 111, 15958–15963. Top. Top. Top. Proc Natl Acad Sci USA 108, 5931-5932. Proc Natl Acad Sci USA 108, 10496-10501. Vázquez-Laslop, N., Ramu, H., Mankin, A. 2011 Nascent peptide in the ribosome exit tunnel affects functional properties of the A-Site of the peptidyl transferase center Mol Cell 41, 321-330. Top. Proc Natl Acad Sci USA 107, 1983-1988. A., Xiong, L., Mankin, A. H D 2010 Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action Proc Natl Acad Sci USA 107, 17152-...
http://mankinlab.cpb.uic.edu/cgi-bin/publication.cgi
*  GO:1900911 regulation of olefin biosynthetic process
... Services. Research. Training. Industry. About us. QuickGO A fast browser for Gene Ontology terms and annotations. EBI Databases QuickGO GO:1900911 regulation of olefin biosynthetic process. Search for terms by keyword or ID: apoptosis GO:0006915 Search for proteins by name or accession: tropomyosin P06727. Web Services. Dataset. Term Basket. Term Information ID GO:1900911. Name regulation of olefin biosynthetic process. Ontology Biological Process. Definition Any process that modulates the frequency, rate or extent of olefin biosynthetic process. GONUTS GO:1900911 Wiki Page. Synonyms. Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details. Type Synonym. exact regulation of olefin synthesis. exact regulation of olefin biosynthesis. exact regulation of olefin formation. exact regulation of olefin anabolism. Ancestor Chart This chart is interactive; ...
http://ebi.ac.uk/QuickGO/GTerm?id=GO:1900911
*  Albums by Smokey Robinson : Rhapsody
... JavaScript is disabled in your browser settings. rhapsody.com requires JavaScript. Cancel. Free trial. x Music. Apps Devices. Pricing. Sign up. Company Info. Careers. Press Media. Partners. Account. Customer Support. Redeem Coupon. Buy a Gift. 2015 Rhapsody International Inc. ×. Rhapsody App for. Rhapsody International, Inc. Get app. Have the app. Music Apps Devices Pricing Listen Now Try Rhapsody. Sign In. Home. / Music. / Soul/R B. / Motown. / Smokey Robinson. / Facebook. Twitter. Albums by Smokey Robinson. Main Releases. Play. Smokey & Friends. Smokey Robinson. Play. Be Near Me. Smokey Robinson. Play. The Motown Years Live. Smokey Robinson. Play. Ev'ry Man Should Know. Smokey Robinson. Play. The Solo Anthology. Smokey Robinson. Play. The Stripped Mixes. Smokey Robinson. Play. Time Flies When You're Having Fun. Smokey Robinson. Play. Love Songs. Smokey Robinson. Play. Timeless Love. Smokey Robinson. Play. The Definitive Collection. Smokey Robinson. Play. 20th Century Masters: The Millennium Collection....
http://rhapsody.com/artist/smokey-robinson/albums
*  Robinson News | News | News Releases | Robinson Memorial Hospital
-Any- Foundation News Robinson News. Foundation Awards Scholarships Benefitting Employees September 25, 2014 The Robinson Memorial Hospital Foundation is pleased to announce the awarding of 9 scholarships to employees of Robinson Memorial Hospital and Rob... Robinson wins NorthCoast 99 Award 12 years in a row September 4, 2014 Robinson Memorial Hospital again has been named as one of the best 99 places to work in Northeast Ohio by the Employers Resource Council. Osteoporosis event to celebrate healthy aging month September 4, 2014 During Robinson Memorial Hospital’s celebration of healthy aging month, there will be a program on Osteoporosis on Wednesday, September 10 from 6 ... Foundation Awards Student Scholarships July 10, 2014 The Robinson Memorial Hospital Foundation is pleased to announce the award of seven scholarships to children of Robinson Memorial Hospital and Robi... Robinson Wound Care Center Joins Healogics, Inc. to Raise Awareness of Chronic Wounds May 29, 2014 The Robinson Wound Care Center at ...
http://robinsonmemorial.org/main/news-releases/451.aspx?email=1
*  Robinson News | News | News Releases | Robinson Memorial Hospital
-Any- Foundation News Robinson News. Foundation Awards Scholarships Benefitting Employees September 25, 2014 The Robinson Memorial Hospital Foundation is pleased to announce the awarding of 9 scholarships to employees of Robinson Memorial Hospital and Rob... Robinson wins NorthCoast 99 Award 12 years in a row September 4, 2014 Robinson Memorial Hospital again has been named as one of the best 99 places to work in Northeast Ohio by the Employers Resource Council. Osteoporosis event to celebrate healthy aging month September 4, 2014 During Robinson Memorial Hospital’s celebration of healthy aging month, there will be a program on Osteoporosis on Wednesday, September 10 from 6 ... Foundation Awards Student Scholarships July 10, 2014 The Robinson Memorial Hospital Foundation is pleased to announce the award of seven scholarships to children of Robinson Memorial Hospital and Robi... Robinson Wound Care Center Joins Healogics, Inc. to Raise Awareness of Chronic Wounds May 29, 2014 The Robinson Wound Care Center at ...
http://robinsonmemorial.org/main/news-releases/fuchs_appointed_as_general_counsel_16.aspx
*  Robinson News | News | News Releases | Robinson Memorial Hospital
-Any- Foundation News Robinson News. Foundation Awards Scholarships Benefitting Employees September 25, 2014 The Robinson Memorial Hospital Foundation is pleased to announce the awarding of 9 scholarships to employees of Robinson Memorial Hospital and Rob... Robinson wins NorthCoast 99 Award 12 years in a row September 4, 2014 Robinson Memorial Hospital again has been named as one of the best 99 places to work in Northeast Ohio by the Employers Resource Council. Osteoporosis event to celebrate healthy aging month September 4, 2014 During Robinson Memorial Hospital’s celebration of healthy aging month, there will be a program on Osteoporosis on Wednesday, September 10 from 6 ... Foundation Awards Student Scholarships July 10, 2014 The Robinson Memorial Hospital Foundation is pleased to announce the award of seven scholarships to children of Robinson Memorial Hospital and Robi... Robinson Wound Care Center Joins Healogics, Inc. to Raise Awareness of Chronic Wounds May 29, 2014 The Robinson Wound Care Center at ...
http://robinsonmemorial.org/main/news-releases/robinson_memorial_presents_poster_at_the_apic_annu_494.aspx?email=1
*  Robinson Health Center at Aurora | Robinson Memorial Hospital
robinson health center at aurora robinson memorial hospital about us foundation volunteer speaker s bureau press room contact us patients visitors medical services nursing find a doctor locations careers patient portal home locations robinson health center at aurora robinson health center at aurora walden place aurora ohio the robinson health center at aurora offers expert physicians personalized care and the latest in medical technology in one convenient location services and physician practices aurora primary care diagnostic x ray and laboratory services northeast ohio ob gyn robinson rehab center and sport clinic directions view larger map your name your email recipient email your comments word verification visitors patient portal key phone numbers visiting hours wheelchair assistance wi fi at robinson memorial hospital locations robinson memorial hospital robinson medical arts building robinson professional center robinson health center at aurora robinson health center at brimfield robinson health center ...
http://robinsonmemorial.org/Main/Aurora.aspx?email=1
*  Home | Robinson Memorial Hospital
Robinson Memorial Hospital. ABOUT US FOUNDATION VOLUNTEER SPEAKER'S BUREAU PRESS ROOM CONTACT US. Patients Visitors. Medical Services. Nursing. Find a Doctor. Locations. Careers. Patient Portal. Classes Events. Holiday Journeys - Grief Support. Mon, Oct 5, 2015. 2:00 PM - 4:00 PM. Holiday Journeys - Grief Support. Mon, Oct 5, 2015. 6:30 PM - 8:30 PM. Ostomy Support Group. Mon, Oct 5, 2015. 7:00 PM - 9:00 PM. Diabetes Support Group. Tue, Oct 6, 2015. 5:00 PM - 6:00 PM. Tue, Oct 6, 2015. 5:00 PM - 6:30 PM. Robinson In The News Robinson Memorial Hospital is now UH Portage Medical Center. Robinson Health System becomes part of University Hospitals on June 1. Robinson Memorial hosts 21st Annual Nursing Research Day. Robinson Memorial Hospital Foundation Hosts 2015 Robinson Society and Heritage Society Distinguished Giving Recognition. Doctors Receiving Top Scores in Patient Satisfaction Congratulations to the following doctors who rank in the 90th percentile on the Press Ganey Patient Satisfaction Survey. Jessica ...
http://robinsonmemorial.org/Main/Home.aspx
*  Rehabilitation | Robinson Memorial Hospital
Rehabilitation. Robinson Memorial Hospital. ABOUT US FOUNDATION VOLUNTEER SPEAKER'S BUREAU PRESS ROOM CONTACT US. Patients Visitors. Medical Services. Locations. Patient Portal. Medical Services. Rehabilitation. Rehabilitation. The Robinson Rehab Center and Sport Clinic works to rehabilitate each patient to his or her maximum potential and works to provide the patient with the necessary skills to maintain his or her progress. Ongoing communication between the patient, therapist and referring physician is the foundation of the center's rehabilitation programs. View Aquatic Classes. Team of Professionals Each therapist strives to stay on top of the latest technology and treatments and passes this knowledge along to patients. All Robinson Rehab Center and Sport Clinic professionals are licensed or certified by the State of Ohio. The center provides:. Aquatic aerobics, aquatic exercise and water arthritis classes in Ravenna. Locations: Robinson Medical Arts Building. 6847 North Chestnut Street Ravenna, Ohio 44266...
http://robinsonmemorial.org/main/rehabilitation.aspx
*  Shamim Patel - UK address and phone number - 192.com
... People. All People Businesses Places Electoral Roll Directors. Make sure the biggest decision you'll make is also the best. People. AZ-People. Surname - Patel. Your results for Shamim Patel. Filter Search. Search by name and/or location using the search form at the top of the page. Get access to likely ages Find old friends and family Double check names of spouses and children Trace your family tree Find out who your neighbours are Verify people are who they say they are. Make sure the biggest decision you'll make is also the best. Find out more. previous. 110 Results for Shamim Patel. Looking for Shamim Patel. Below are the results from the UK Electoral Roll and Company Director data. You can narrow your search by adding a location above if you wish. Name Address Other Occupants Electoral Roll Director Info Length of Occupancy Neighbours Property Price. 1 Shamim Patel. Age Guide: 40-44. Reading, Berkshire, RG2 Full Address. View. 2 Shamim R Patel. Age Guide: 30-34. Leicester, Leicestershire, LE5 Full Ad...
http://192.com/atoz/people/patel/shamim/
*  Phillip Phillips News, Pictures, and Videos | TMZ.com
Home Celebs Phillip Phillips Phillip Phillips. Idol Managers Claim John Mayer's ex-manager plotted to jack "American Idol" champ Phillip Phillips out from under his contract with the show -- according to a new lawsuit, but the bigger news is Phil is a READ MORE > - 9/21/2015 2:51 PM PDT. Phillip Phillips I Want to be Gone, Gone, Gone From My Idol Contract Phillip Phillips says "American Idol" producers are ruining his career ... American Idol Winner Phillip Phillips Mother Popped for DUI Phillip Phillips' mother Sheryl Phillips -- who appeared on several episodes of "American Idol" during Phillip's championship run last season -- was arrested for DUI earlier today, TMZ has READ MORE > - 964 days ago. Phillip Phillips I LOVE MY FAMILY But ... READ MORE > - 1064 days ago. Phillip Phillips Family Idol Champ s Forcing Us To Sell Pawn Shop Phillip Phillips' family says the singer left them high and dry after winning "American Idol" -- refusing to help them out financially -- and now, they've been forced to sell th...
http://tmz.com/person/phillip-phillips/?adid=cr_featured_saga_13
*  Shadowing | Robinson Memorial Hospital
Shadowing. Robinson Memorial Hospital. ABOUT US FOUNDATION VOLUNTEER SPEAKER'S BUREAU PRESS ROOM CONTACT US. Patients Visitors. Medical Services. Nursing. Find a Doctor. Locations. Careers. Patient Portal. Home. Volunteer. Shadowing. Shadowing. Robinson Memorial Hospital offers several types of opportunities for short-term observational learning experiences for high school, college and adult students pursuing healthcare careers. The process to apply for a shadow experience depends on the age of the applicant. Note: Robinson Memorial Hospital has a mandatory flu vaccination policy for all employees, volunteers, contracted workers and shadow students. Students wanting to shadow at Robinson Memorial must provide proof of receiving a flu vaccine during current flu season - either by a receipt showing the student's name and detail of service from the provider, an insurance benefits explanation or detailed note from a physician. Students can bring their vaccine documentation the morning of their assigned shadow exp...
http://robinsonmemorial.org/Main/Shadowing.aspx
*  [Haskell-cafe] System.Random.Shuffle fix
System.Random.Shuffle fix. System.Random.Shuffle fix friggin friggin frigginfriggins at gmail.com. Previous message: A small display problem using Helium Next message: System.Random.Shuffle fix Messages sorted by:. I was looking for a shuffling algorithm to shuffle mp3-playlists so was very happy to see System.Random.Shuffle: http://hackage.haskell.org/cgi-bin/hackage-scripts/package/random-shuffle-0.0.2 However I get errors,non-exhaustive patterns in function shufleTree or extractTree depending how I call it. Errors are at the bottom. I fixed it but I don't have the math skills to see if I perhaps broke it statistically ... Here is my fix, someone don't remember who, helped me a little : http://hpaste.org/fastcgi/hpaste.fcgi/view?id=2789#a2789 the shuffle at the end is with the fix. *Freet S.shuffle Loading package syb ... linking ... Loading package base-3.0.3.0 ... linking ... Loading package old-locale-1.0.0.1 ... linking ... Loading package old-time-1.0.0.1 ... linking ... Loading package random-1.0.0.1 ...
https://mail.haskell.org/pipermail/haskell-cafe/2009-March/058399.html
*  OriGene - LRRC2 (NM 024512) cDNA Clone
OriGene - LRRC2 NM 024512 cDNA Clone. cDNA Clones TrueORF cDNA Clones H/M/R Viral ORF Clones Destination Vector TrueClone Human TrueClone Mouse Organelle Marker Plasmids MicroRNA Tools Mutant and Variant Clones Plasmid Purification Kits Transfection Reagents Gene Synthesis Service. Home TrueClone LRRC2 Clone. LRRC2 NM 024512 Human cDNA Clone. SC310473 LRRC2 untagged -Human leucine rich repeat containing 2 LRRC2, NM 024512.2, 10ug $680 3 weeks. Reference Data RefSeq: NM 024512.2, NP 078788. Synonyms : leucine-rich repeat-containing 2; leucine rich repeat containing 2. More TrueClone Citations >>. LRRC2 Mouse Clones SKU Description Amount Price Shipping. MC211501 Lrrc2 untagged - Mouse leucine rich repeat containing 2 Lrrc2, 10ug 10 ug $380 3 weeks. MR216368 Lrrc2 Myc-DDK-tagged - Mouse leucine rich repeat containing 2 Lrrc2 10 ug $380 Next day. MG216368 Lrrc2 GFP-tagged - Mouse leucine rich repeat containing 2 Lrrc2, 10ug 10 ug $420 3 weeks. MR216368L1 Lenti ORF clone of Lrrc2 Myc-DDK-tagged - Mouse leucine ri...
http://origene.com/cdna/trueclone/accession/NM_024512/SC310473.aspx
*  JUST LIKE A WOMAN LYRICS - BOB DYLAN
just like a woman lyrics bob dylan sing lyrics bob dylan biography bob dylan albums bob dylan lyrics bob dylan just like a woman lyrics last updated pm sponsored links nobody feels any pain tonight as i stand inside the rain ev rybody knows that baby s got new clothes but lately i see her ribbons and her bows have fallen from her curls she takes just like a woman yes she does she makes love just like a woman yes she does and she aches just like a woman but she breaks just like a little girl queen mary she s my friend yes i believe i ll go see her again nobody has to guess that baby can t be blessed till she finally sees that she s like all the rest with her fog her amphetamine and her pearls she takes just like a woman yes she does she makes love just like a woman yes she does and she aches just like a woman but she breaks just like a little girl it s was raining from the first and i was dying there of thirst so i came in here and your long time curse hurts but what s worse is this pain in here i can t stay i...
http://sing365.com/music/Lyric.nsf/Just-Like-A-Woman-lyrics-Bob-Dylan/659E935998737E48482569690029ABC7
*  Gary Phillips eBooks | epub and pdf downloads | eBookMall
Gary Phillips eBooks. epub and pdf downloads. eBookMall. Search. Sponsored link: What is YOUR Secret Talent. - Take a Free Personality test. Gary Phillips eBooks Epub and PDF format. Gary Phillips eBooks. eBooks found: 15 Occupied Earth: Stories of Aliens, Resistance and Survival at all Costs. Richard Brewer. Gary Phillips Polis Books, October 2015. ISBN: 9781940610528 Format: ePub. List Price: $ 9.99 Our price: $ 7.99. Violent Spring. Gary Phillips mysteriouspress.com, June 2014. ISBN: 9781784087968 Format: ePub. List Price: $ 13.11 Our price: $ 9.99. Perdition, U.S.A. Gary Phillips mysteriouspress.com, June 2014. ISBN: 9781784087975 Format: ePub. List Price: $ 13.11 Our price: $ 9.99. Bad Night Is Falling. Gary Phillips mysteriouspress.com, June 2014. ISBN: 9781784087982 Format: ePub. List Price: $ 13.11 Our price: $ 9.99. Only the Wicked. Gary Phillips mysteriouspress.com, June 2014. ISBN: 9781784087951 Format: ePub. List Price: $ 13.11 Our price: $ 9.99. The Extractors. Gary Phillips Stark Raving Group, M...
http://ebookmall.com/author/gary-phillips
*  "Beyond Stroke" Support Group | Events | Calendar of Events | Robinson Memorial Hospital
beyond stroke support group events calendar of events robinson memorial hospital about us foundation volunteer speaker s bureau press room contact us patients visitors medical services nursing find a doctor locations careers patient portal beyond stroke support group calendar view back to previous page support groups tuesday october pm pm description stroke survivors and caregivers will benefit from information presented by a variety of speakers as well as from sharing and support of their peers for information call jan bahle at location robinson medical arts building rmab n chestnut st ravenna ohio contact healtheducation rmh org phone visitors patient portal key phone numbers visiting hours wheelchair assistance wi fi at robinson memorial hospital locations robinson memorial hospital robinson medical arts building robinson professional center robinson health center at aurora robinson hea...
http://robinsonmemorial.org/Main/Calendar/659.aspx
*  Deposition of Bobby Phillips States That Erwin Cain Sold Cocaine
... Home About Stories. Featured. BOR Featured. User Stories. Deposition of Bobby Phillips States That Erwin Cain Sold Cocaine. Deposition of Bobby Phillips States That Erwin Cain Sold Cocaine 3. By Burnt Orange Report. on October 19, 2010. Bobby Phillips, Jr. Phillips states that he met Erwin Cain in October of 1977, when he was engaged to Erwin's sister, Gloria Cain. Attorney : Did you ever see Mr. Erwin Cain sell drugs. Phillips : Yeah, I've seen him deliver to his brother-in-law, to his brother, and to other people that came by the house when he was there. Attorney : Do you know where Thomas Cain, Jr. Attorney: which brother would that be. Phillips : Erwin. Attorney: Just to clarify, and let me repeat it's your statement that you have seen, in the past, a man you can identify as Erwin Cain use marijuana. Phillips : Yes. Attorney: Have you, and is it your statement also that you have seen him sell marijuana to someone. Phillips : Yeah. Phillips : It was usually just we used to go over to his h...
http://burntorangereport.com/diary/10880/deposition-of-bobby-phillips-states-that-erwin-cain-sold-cocaine
*  Anthony Robinson | dafont.com
Anthony Robinson. dafont.com. English. Fran ais. Espa ol. Deutsch. Italiano. Portugu s Login. Register. Themes New fonts Authors Top Forum FAQ Submit a font Tools. 4 matching requests on the forum Anthony Robinson 1. 2 3. Anthony Robinson. View profile Send a private message http://www.redbubble.com/people/anfa/portfolio 58 fonts - 4,331,510 downloads 2,129 yesterday. Preview. Fonts 10 20 50 100. Show variants. Size Tiny Small Medium Large Sort by Name Popularity Newer first. More options. Only as. Public domain / GPL / OFL. 100% Free. Free for personal use. Donationware. Shareware. Demo. Unknown Only fonts with. Accents. Euro. Newcastle by Anthony Robinson. in Fancy. Decorative 15,200 downloads 4 yesterday. 100% Free - 2 font files Download Donate to author. Static Buzz by Anthony Robinson. in Fancy. Distorted 104,264 downloads 4 yesterday. 100% Free Download Donate to author. Lasso Of Truth by Anthony Robinson. in Gothic. Modern 5,855 downloads 4 yesterday. 100% Free Download Donate to author. Punched by An...
http://dafont.com/anthony-robinson.d2796?page=3
*  Anthony Robinson | dafont.com
Anthony Robinson. dafont.com. English. Fran ais. Espa ol. Deutsch. Italiano. Portugu s Login. Register. Themes New fonts Authors Top Forum FAQ Submit a font Tools. 4 matching requests on the forum Anthony Robinson 1. 2 3. Anthony Robinson. View profile Send a private message http://www.redbubble.com/people/anfa/portfolio 58 fonts - 4,333,980 downloads 2,470 yesterday. Preview. Fonts 10 20 50 100. Show variants. Size Tiny Small Medium Large Sort by Name Popularity Newer first Reinitialize More options. Only as. Public domain / GPL / OFL. 100% Free. Free for personal use. Donationware. Shareware. Demo. Unknown Only fonts with. Accents. Euro. First by Anthony Robinson. in Techno. Sci-fi 12,112 downloads 3 yesterday. 100% Free Download Donate to author. Newcastle by Anthony Robinson. in Fancy. Decorative 15,203 downloads 3 yesterday. 100% Free - 2 font files Download Donate to author. New York Punk by Anthony Robinson. in Fancy. Destroy 20,765 downloads 3 yesterday. 100% Free Download Donate to author. Lasso Of T...
http://dafont.com/anthony-robinson.d2796?page=5&text=AUBURN
*  Phillip Phillips Ringtones Free Download - Ringtone Maker Audiko
... Sublime, Kendrick Lamar, DevilDriver, K. Michelle, Five Finger Death Punch. Mobile apps. Login. JavaScript must be enabled in order for you to use Audiko in standard view. A B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S. T. U. V. W. X. Y. Z. 0...9. Thousands of ringtones on Audiko.net. Here is a chance to download a free Phillip Phillips ringtones for your iPhone or mobile. Specify your favorite line from your favorite award-winning track - Beggin, Get Up Get Down, Unpack Your Heart, or any other track. You may download your ringtone both in the MP3 and m4a formats, supported by both mobile phones and iPhones. Just select a track, and choose free Phillip Phillips ringtones download option. Download Phillip Phillips Ringtones. Top free ringtones. Name. Gone, Gone, Gone. Home. Raging Fire. Alive Again. Face. Get Up Get Down. Searchlight. Volcano. U Got It Bad. We've Got Tonight. Albums. Behind the Light Deluxe Version. Phillip Phillips. Weve Got Tonight American Idol Performance Single. Phillip Phil...
http://audiko.net/ringtone/phillip-phillips
*  Coles Phillips
... 'Clarence Coles Phillips' October 1880June 13, 1927 was an American artist and illustrator who signed his early works 'C. Coles Phillips', but after 1911 worked under the abbreviated name, 'Coles Phillips'. He is known for his stylish images of women and a signature use of negative space in the paintings he created for advertisements and the covers of popular magazines. Early life Career Personal life Notes References External links. Early life. ' ' Michael Schau, Watson-Guptill, 1975, p. Image:Coles Phillips2 Life.jpg The work of Phillips quickly became popular with the 'Life' readers. Schau & Phillips 1975, p. Phillips' use of negative space allowed the viewer to "fill-in" the image; it also reduced printing costs for the magazine, as "the novelty of the technique and the striking design qualities masked the fact that 'Life' was getting by with single color or two-color covers in a day when full-color covers were de rigueur for the better magazines". Phillips worked in watercolor and always painted fro...
https://en.wikipedia.org/wiki/Coles_Phillips
*  Phillip Phillips News, Pictures, and Videos | TMZ.com
Idol Managers Claim John Mayer's ex-manager plotted to jack "American Idol" champ Phillip Phillips out from under his contract with the show -- according to a new lawsuit, but the bigger news is Phil is a READ MORE > - 9/21/2015 2:51 PM PDT. Phillip Phillips I Want to be Gone, Gone, Gone From My Idol Contract Phillip Phillips says "American Idol" producers are ruining his career ... American Idol Winner Phillip Phillips Mother Popped for DUI Phillip Phillips' mother Sheryl Phillips -- who appeared on several episodes of "American Idol" during Phillip's championship run last season -- was arrested for DUI earlier today, TMZ has READ MORE > - 963 days ago. READ MORE > - 1063 days ago. Phillip Phillips Family Idol Champ s Forcing Us To Sell Pawn Shop Phillip Phillips' family says the singer left them high and dry after winning "American Idol" -- refusing to help them out financially -- and now, they've been forced to sell their cherished READ MORE > - 1066 days ago. Phillip Phillips Crooks Smash In Pawn Shop, St...
http://tmz.com/person/phillip-phillips/?adid=cr_featured_saga_14
*  HERBICIDE-TOLERANT PLANTS - BASF AGROCHEMICAL PRODUCTS.B.V.
In addition, enzymes of this embodiment will also comprise one or more of a leucine, threonine, a valine, or alanine at position 1,781 Am, a glycine at position l,785 Am, a proline at position l,786 Am, an asparagine at position 1,811 Am, a proline at position l,824 Am, a cysteine or glycine at position l,999 Am, a cysteine or arginine at position 2,027 ' Am, a glycine at position 2,039 Am, an asparagine at position 2,041 Am, a phenylalanine, isoleucine or leucine at position 2,049 Am, a valine at position 2,059 Am, a leucine at position 2,074 Am, a leucine, isoleucine, methionine or additional valine at position 2,075 Am, a glycine or threonine at position 2,078 Am, a phenylalanine at position 2,079 Am, a glutamic acid at position 2,080 Am, a deletion at position 2,080 Am, a deletion at position 2,081 Am, an arginine, tryptophan, phenylalanine, glycine, histidine, lysine, leucine, serine, threonine, or valine at position 2,088 Am, a glutamic acid at position 2,095 Am, an alanine or serine at position 2,096 A...
http://sumobrain.com/patents/wipo/Herbicide-tolerant-plants/WO2011028836.html
*  Bimolecular fluorescence complementation
This was achieved by dissecting GFP into C- and N-terminal GFP fragments. In addition, this study was the first report of an ' in vivo ' technique, now known as the bimolecular fluorescence complementation BiFC assay, to provide insight into the structural basis of protein complex formation through detection of fluorescence caused by the assembly of fluorescent reporter protein fragments tethered to interacting proteins. Generally, YFP is recommended to serve as the reporter protein, cleaved at residue 155 N-terminal consisting of residues 1–154 and C-terminal consisting of residues 155–238 or residue 173 in particular, as these sets of fragments are highly efficient in their complementation when fused to many interacting proteins and they produce low levels fluorescence when fused to non-interacting proteins. It is suggested that each target protein is fused to both the N- and C-terminal fragments of the fluorescent reporter protein in turn, and that the fragments are fused at each of the N- and C-terminal e...
https://en.wikipedia.org/wiki/Bimolecular_fluorescence_complementation
*  Candice Olson Family Spaces ISBN 9781118276679 PDF epub | Candice Olson ebook | eBookMall
Candice Olson Family Spaces ISBN 9781118276679 PDF epub. Candice Olson ebook. eBookMall. Candice Olson Family Spaces. Candice Olson. Design : Interior Decorating. Digital Book format: ePub Adobe DRM. Buy ePub. List price: $ 19.99 Our price: $ 16.99. Popular TV star Candice Olson shows you how to create your dream family room Everybody wants their home's main living space to meet the needs of the whole family—and look great doing it. Chock full of tips and ideas, Candice Olson Family Spaces features hundreds of full-color, before-and-after photos of Candice's stunning family room makeovers. Explains how good design accommodates all members of the family and their daily activities Designs offer functionality, durability, and comfort without sacrificing style As a busy mother of two, Candice brings valuable insight to what a family really needs from the spaces they share Redecorating—or even just dreaming about decorating—can transform one's outlook on life, and Candice Olson Family Spaces is the catalyst to get...
http://ebookmall.com/ebook/candice-olson-family-spaces/candice-olson/9781118276679
*  Abner Phillips (1737-1813), p.2
Abner Phillips - Surry County, NC There were Phillips in Surry County, NC as early as 1771, according to tax lists. Lewis' Dist.: Abner PHILLIPS, 400 acres, 1 white poll. LEWIS to Abner PHILLIPS, 300 acres on north side of Yadkin River, east side Turkey Creek, for 75. LEWIS to Abner PHILLIPS, 100 acres on north side of Yadkin River at Turkey Creek, for 75. Phillips Dist.: Abner PHILLIPS, 400 acres, 2 white polls. 1790 Census, Surry Co., NC, p.186: ABNER PHILLIPS 3 white males under 16 2 white males over 16 3 white females no slaves Note: Abner's sons Cornelius PHILLIPS and Ephraim PHILLIPS are also listed in the 1790 Census of Surry Co., NC, p.183. 1800 Census, Surry Co., NC: ABNER PHILLIPS. 1810 Census, Surry Co., NC, p.193: ABNER PHILLIPS. In the name of God Amen this tenth day of November in year of our lord 1812 I ABNER PHILLIPS of Surry County State of North Carolina being sick and weak in Body but in perfect mind memory thanks be given to God For the Same Calling unto mind the mortality of my bo...
http://moonzstuff.com/phillips/abner1737_p2.html
*  "Dear Abby" Advice Columnist Pauline Phillips Dead at 94 - Us Weekly
... US Weekly. News. Photos. Style. Beauty. Moms. Body. Entertainment. Subscribe. Give a Gift. Us Weekly. Newsletter. Subscribe. ADVERTISEMENT. "Dear Abby" Advice Columnist Pauline Phillips Dead at 94. Celebrity News. Jan. Tweet. Columnist Abigail Van Buren attends Friends Of Mario Cuomo Fundraiser Dinner on November 30, 1989 at the Sheraton Center in New York City. Newspapers -- and readers -- the world over lost an icon Wednesday, Jan. 16, after "Dear Abby" advice columnist Pauline Phillips died in Minneapolis at the age of 94. Phillips had suffered from Alzheimer's disease for years, but was still dishing out advice to readers as recently as 2002, though her daughter Jeanne took on co-authoring duties in the mid-1990s. PHOTOS: Stars we lost in 2012. Phillips, who wrote under the pen name Abigail Van Buren, shared advice on everything from dating to snoring spouses for more than 40 years to a readership of more than 90 million newspaper readers. "They gave her a bunch of letters, thinking that they would n...
http://usmagazine.com/celebrity-news/news/dear-abby-advice-columnist-pauline-phillips-dead-at-94-2013171
*  Joanna Phillips | UCSF Medical Center
Joanna Phillips. UCSF Medical Center. About UCSF. Find a Doctor. Conditions Treatments. Conditions Treatments A-Z. Patient Education. Doctors. Find a Doctor. Getting to UCSF Medical Center. Careers at UCSF Medical Center. UCSF Medical Group. Home > Doctors > Joanna Phillips. Find a Doctor. Joanna Phillips, M.D. Joanna Phillips is a neuropathologist at UCSF Medical Center who helps diagnose neurologic disease through the examination of central nervous system tissue. As an academic neuropathologist, her goal is to improve the treatment of brain tumors through research and patient care. She completed a pathology residency at the University of Washington in Seattle, followed by a fellowship in neuropathology at UCSF. Phillips is a member of several professional organizations, including the American Society for Investigative Pathology, American Association of Neuropathologists, American Association for Cancer Research and Glycobiology Research and Training Program. Safaee M, Fakurnejad S, Bloch O, Clark AJ, Ivan M...
http://ucsfhealth.org/joanna.phillips
*  SMART: Secondary literature for GLUCA domain
smart secondary literature for gluca domain smart mode normal genomic schultz et al proc natl acad sci usa letunic et al nucleic acids res doi nar gku home setup faq about glossary what s new feedback secondary literature sources for gluca the following references were automatically generated lopez lc frazier ml su cj kumar a saunders gf mammalian pancreatic preproglucagon contains three glucagon related peptides proc natl acad sci u s a display abstract we have isolated cdna clones encoding bovine pancreatic preproglucagon twenty five putative preproglucagon clones were selected by screening clones of a fetal bovine pancreas cdna library with a synthetic oligodeoxynucleotide probe the probe was a mixture of synthetic base dna oligomers constructed to correspond to the six carboxyl terminal amino acids residues of mature glucagon restriction mapping of six of these clones suggested that they represented a single mrna species primary sequence analysis of one clone containing a base pair dna insert revealed tha...
http://smart.embl-heidelberg.de/smart/show_secondary.cgi?domain=GLUCA
*  viruses share common: Topics by Science.gov
... Toggle navigation. Topics by Science.gov Home. Site Map. Index. Alerts. Help. Contact Us. About. Sample records for viruses share common. 1 2. 3. 4. 5. . . To gain insights into the role and specificity of hepaciviral nonstructural protein 2 NS2, which is required for HCV polyprotein processing and particle morphogenesis, we investigated whether NS2 structural and functional features are conserved between HCV and GBV-B. We found that GBV-B NS2, like HCV NS2, has cysteine protease activity responsible for cleavage at the NS2/NS3 junction, and we experimentally confirmed the location of this junction within the viral polyprotein. A model for GBV-B NS2 membrane topology was experimentally established by determining the membrane association properties of NS2 segments fused to green fluorescent protein GFP and their nuclear magnetic resonance structures using synthetic peptides as well as by applying an N-glycosylation scanning approach. Similar glycosylation studies confirmed the HCV NS2 organization. Togeth...
http://science.gov/topicpages/v/viruses share common.html
*  VPR: Andrea Phillips thanks President Obama, military for her husband's rescue
... .  Archive Home .  VPR.net Home . Andrea Phillips thanks President Obama, military for her husband's rescue. 04/13/09 5:42PM By Ross Sneyd.  MP3 .  Download MP3 . AP Photo/Toby Talbot. Andrea Phillips is flanked by her son, Daniel, and daughter, Mariah. Host A day after her husband was rescued from Somali pirates, Andrea Phillips said she wanted to thank friends, officials and especially President Obama for their support during the crisis. In a short news conference in South Burlington today, Phillips also said she had also been able to speak with her husband by telephone. VPR's Ross Sneyd has more. Sneyd Andrea Phillips has had the flu since a day before her husband's capture - and she's just now recovering. Since last week, when it became clear that Richard Phillips had given himself up to the pirates to protect the crew on his Merchant Marine ship, she's stayed out of the spotlight. She said her husband got a laugh out of her condition, knowing that she would be appeari...
http://vpr.net/news_detail/84680/andrea-phillips-thanks-president-obama-military-fo/
*  Protein superfamily
A 'protein superfamily' is the largest grouping clade of proteins for which common ancestry can be inferred see homology. Usually this common ancestry is based on structural alignment. and mechanistic similarity even though no sequence similarity is evident. 2 Superfamilies typically contain several protein families which show sequence similarity within the family. The term 'protein clan' is commonly used for protease superfamilies based on the MEROPS protease classification system. Identification Sequence homology. Structural homology. Mechanistic similarity. Evolutionary significance Examples Protein superfamily resources See also References. Sequence homology. sequence homology. Superfamily members typically show no detectable sequence homology. In the PA clan of protease s, for example, not a single residue is conserved through the superfamily, not even those in the catalytic triad. Conversely, the individual families that make up a superfamily are defined on the basis of their sequence alignment, for exa...
https://en.wikipedia.org/wiki/Protein_superfamily
*  Publications | NEB
FEBS Lett. Proc.Natl.Acad.Sci.USA J Parasitol. Proteins Mol.Cell.Biol. CABIOS Glycobiology Proceeding of the Heartworm Symposium Biotechnology Biochemistry Parasitology Today Science Archaea A Laboratory Manual Parasitology Proc Natl Acad Sci Clinical and Diagnostic Laboratory Immunology Abstracts Of Papers Of The American Chemical Society Accountability in Research Genetic Analysis Biomolecular Engineering Enzymes and Proteins from Hyperthermophilic Microorganisms, Advs.Protein Chemistry Genetics Society of America Nuc.Acids Res. Protein Sci Proc. Nucleic Acids Research BMC Res Notes J Steroid Biochem Mol Biol World J. J Bacteriol Biotechnology Journal Biomedical Optics Express Nucleic Acids Res. Plant Cell Nature Chemistry Methods in Molecular Biology Mol Cell Biol. J Cell Sci BMC Microbiol Protein Cell Gene Ther Appl Microbiol Biotechnol Nat Biotechnol Front Physiol Appl Environ Microbiol Viruses Applications in Plant Sciences G3 Bethesda J Virol Anal Biochem AMB Express PLoS Pathog Curr Opin Chem Biol J B...
https://neb.com/research/publications?page=3&start=30&num=10&sorting=Year&asc=False
*  Publications | NEB
Proc.Natl.Acad.Sci.USA Molecular Paradigms for Eradicating Helmenthic Parasites Exp.Parasitol. Appl.Environ.Microbiol., Trop.Med.Parasitol. Proc.Natl.Acad.Sci.USA J Parasitol. CABIOS Glycobiology Proceeding of the Heartworm Symposium Biotechnology Biochemistry Parasitology Today Science Archaea A Laboratory Manual Parasitology Proc Natl Acad Sci Clinical and Diagnostic Laboratory Immunology Abstracts Of Papers Of The American Chemical Society Accountability in Research Genetic Analysis Biomolecular Engineering Enzymes and Proteins from Hyperthermophilic Microorganisms, Advs.Protein Chemistry Genetics Society of America Nuc.Acids Res. Biochem J. NY Proc.Natl.Acad.Sci. Nucleic Acids Research BMC Res Notes J Steroid Biochem Mol Biol World J. J Bacteriol Biotechnology Journal Biomedical Optics Express Nucleic Acids Res. Plant Cell Nature Chemistry Methods in Molecular Biology Mol Cell Biol. J Cell Sci BMC Microbiol Protein Cell Gene Ther Appl Microbiol Biotechnol Nat Biotechnol Front Physiol Appl Environ Microbio...
https://neb.com/research/publications?num=50&sorting=&asc=False
*  Publications | NEB
FEBS Lett. Proc.Natl.Acad.Sci.USA J Parasitol. CABIOS Glycobiology Proceeding of the Heartworm Symposium Biotechnology Biochemistry Parasitology Today Science Archaea A Laboratory Manual Parasitology Proc Natl Acad Sci Clinical and Diagnostic Laboratory Immunology Abstracts Of Papers Of The American Chemical Society Accountability in Research Genetic Analysis Biomolecular Engineering Enzymes and Proteins from Hyperthermophilic Microorganisms, Advs.Protein Chemistry Genetics Society of America Nuc.Acids Res. Nucleic Acids Research BMC Res Notes J Steroid Biochem Mol Biol World J. J Bacteriol Biotechnology Journal Biomedical Optics Express Nucleic Acids Res. Plant Cell Nature Chemistry Methods in Molecular Biology Mol Cell Biol. J Cell Sci BMC Microbiol Protein Cell Gene Ther Appl Microbiol Biotechnol Nat Biotechnol Front Physiol Appl Environ Microbiol Viruses Applications in Plant Sciences G3 Bethesda J Virol Anal Biochem AMB Express PLoS Pathog Curr Opin Chem Biol J Biol Eng Mol Biol Evol PLoS Genet Biology B...
https://neb.com/sitecore/content/nebsg/home/research/publications?Page=2&sorting=Year
*  Par stability determinant
... notoc the par stability determinant is a bp locus of the pad plasmid which encodes a type i toxin antitoxin system in enterococcus faecalis it was the first such plasmid addiction module to be found in gram positive bacteria the par locus contains two gene s fst which encodes a amino acid toxic protein and a gene for rnaii the small rna anti toxin which inhibits fst translation the two genes are found on opposite dna strands and share a region which is where they are thought to have an antisense interaction their rna secondary structure s have been predicted computationally the complementary regions appear to be presented on exposed loops for interaction par maintains pad by means of post segregational killing psk if a daughter cell does not inherit the par locus the unstable rnaii will quickly degrade leaving the long lived fst toxin to damage or kill the daughter cell see also references further reading external links see also hok sok system references further reading external links category antisense ...
https://en.wikipedia.org/wiki/Par_stability_determinant
*  Publications | NEB
Proc.Natl.Acad.Sci.USA J Parasitol. CABIOS Glycobiology Proceeding of the Heartworm Symposium Biotechnology Biochemistry Parasitology Today Science Archaea A Laboratory Manual Parasitology Proc Natl Acad Sci Clinical and Diagnostic Laboratory Immunology Abstracts Of Papers Of The American Chemical Society Accountability in Research Genetic Analysis Biomolecular Engineering Enzymes and Proteins from Hyperthermophilic Microorganisms, Advs.Protein Chemistry Genetics Society of America Nuc.Acids Res. Nucleic Acids Research BMC Res Notes J Steroid Biochem Mol Biol World J. J Bacteriol Biotechnology Journal Biomedical Optics Express Nucleic Acids Res. Plant Cell Nature Chemistry Methods in Molecular Biology Mol Cell Biol. J Cell Sci BMC Microbiol Protein Cell Gene Ther Appl Microbiol Biotechnol Nat Biotechnol Front Physiol Appl Environ Microbiol Viruses Applications in Plant Sciences G3 Bethesda J Virol Anal Biochem AMB Express PLoS Pathog Curr Opin Chem Biol J Biol Eng Mol Biol Evol PLoS Genet Biology Basel Front ...
https://neb.com/research/publications?Page=29&asc=False
*  Publications | NEB
Proc.Natl.Acad.Sci.USA J Parasitol. CABIOS Glycobiology Proceeding of the Heartworm Symposium Biotechnology Biochemistry Parasitology Today Science Archaea A Laboratory Manual Parasitology Proc Natl Acad Sci Clinical and Diagnostic Laboratory Immunology Abstracts Of Papers Of The American Chemical Society Accountability in Research Genetic Analysis Biomolecular Engineering Enzymes and Proteins from Hyperthermophilic Microorganisms, Advs.Protein Chemistry Genetics Society of America Nuc.Acids Res. Nucleic Acids Research BMC Res Notes J Steroid Biochem Mol Biol World J. J Bacteriol Biotechnology Journal Biomedical Optics Express Nucleic Acids Res. Plant Cell Nature Chemistry Methods in Molecular Biology Mol Cell Biol. J Cell Sci BMC Microbiol Protein Cell Gene Ther Appl Microbiol Biotechnol Nat Biotechnol Front Physiol Appl Environ Microbiol Viruses Applications in Plant Sciences G3 Bethesda J Virol Anal Biochem AMB Express PLoS Pathog Curr Opin Chem Biol J Biol Eng Mol Biol Evol PLoS Genet Biology Basel Front ...
https://neb.com/research/publications?Page=55
*  Publications | NEB
Proc.Natl.Acad.Sci.USA J Parasitol. CABIOS Glycobiology Proceeding of the Heartworm Symposium Biotechnology Biochemistry Parasitology Today Science Archaea A Laboratory Manual Parasitology Proc Natl Acad Sci Clinical and Diagnostic Laboratory Immunology Abstracts Of Papers Of The American Chemical Society Accountability in Research Genetic Analysis Biomolecular Engineering Enzymes and Proteins from Hyperthermophilic Microorganisms, Advs.Protein Chemistry Genetics Society of America Nuc.Acids Res. Nucleic Acids Research BMC Res Notes J Steroid Biochem Mol Biol World J. J Bacteriol Biotechnology Journal Biomedical Optics Express Nucleic Acids Res. Plant Cell Nature Chemistry Methods in Molecular Biology Mol Cell Biol. J Cell Sci BMC Microbiol Protein Cell Gene Ther Appl Microbiol Biotechnol Nat Biotechnol Front Physiol Appl Environ Microbiol Viruses Applications in Plant Sciences G3 Bethesda J Virol Anal Biochem AMB Express PLoS Pathog Curr Opin Chem Biol J Biol Eng Mol Biol Evol PLoS Genet Biology Basel Front ...
https://neb.com/research/publications?page=50&start=500&num=10
*  Publications | NEB
Proc.Natl.Acad.Sci.USA J Parasitol. CABIOS Glycobiology Proceeding of the Heartworm Symposium Biotechnology Biochemistry Parasitology Today Science Archaea A Laboratory Manual Parasitology Proc Natl Acad Sci Clinical and Diagnostic Laboratory Immunology Abstracts Of Papers Of The American Chemical Society Accountability in Research Genetic Analysis Biomolecular Engineering Enzymes and Proteins from Hyperthermophilic Microorganisms, Advs.Protein Chemistry Genetics Society of America Nuc.Acids Res. Nucleic Acids Research BMC Res Notes J Steroid Biochem Mol Biol World J. J Bacteriol Biotechnology Journal Biomedical Optics Express Nucleic Acids Res. Plant Cell Nature Chemistry Methods in Molecular Biology Mol Cell Biol. J Cell Sci BMC Microbiol Protein Cell Gene Ther Appl Microbiol Biotechnol Nat Biotechnol Front Physiol Appl Environ Microbiol Viruses Applications in Plant Sciences G3 Bethesda J Virol Anal Biochem AMB Express PLoS Pathog Curr Opin Chem Biol J Biol Eng Mol Biol Evol PLoS Genet Biology Basel Front ...
https://neb.com/sitecore/content/nebsg/home/research/publications?Page=47
*  Publications | NEB
Proc.Natl.Acad.Sci.USA J Parasitol. CABIOS Glycobiology Proceeding of the Heartworm Symposium Biotechnology Biochemistry Parasitology Today Science Archaea A Laboratory Manual Parasitology Proc Natl Acad Sci Clinical and Diagnostic Laboratory Immunology Abstracts Of Papers Of The American Chemical Society Accountability in Research Genetic Analysis Biomolecular Engineering Enzymes and Proteins from Hyperthermophilic Microorganisms, Advs.Protein Chemistry Genetics Society of America Nuc.Acids Res. Nucleic Acids Research BMC Res Notes J Steroid Biochem Mol Biol World J. J Bacteriol Biotechnology Journal Biomedical Optics Express Nucleic Acids Res. Plant Cell Nature Chemistry Methods in Molecular Biology Mol Cell Biol. J Cell Sci BMC Microbiol Protein Cell Gene Ther Appl Microbiol Biotechnol Nat Biotechnol Front Physiol Appl Environ Microbiol Viruses Applications in Plant Sciences G3 Bethesda J Virol Anal Biochem AMB Express PLoS Pathog Curr Opin Chem Biol J Biol Eng Mol Biol Evol PLoS Genet Biology Basel Front ...
https://neb.com/sitecore/content/nebsg/home/research/publications?page=52&start=520&num=10&asc=False
*  .. Post navigation .. Happy Birthday Duncan Phillips .. Post navigation
post navigation square dancing last chance o is for origin story happy birthday duncan phillips posted on june by sarah osborne bender clockwise from top left milton avery black sea oil on canvas x in the phillips collection washington d c acquired robert motherwell in white and yellow ochre oil charcoal ink tempera and paper collage on paper x in the phillips collection washington d c acquired alexander calder only only bird tin cans and wire x x in the phillips collection washington d c acquired karl knaths the blue heron at the tide wash oil on canvas x in the phillips collection washington d c acquired i had the pleasure of speaking last night to alice phillips swistel great niece of duncan phillips who was born today in it s not surprising that the conversation came around to her memories of him though i ve worked here for over five years and handled many of phillips s belongings his j...
http://blog.phillipscollection.org/2012/06/26/happy-birthday-duncan-phillips/
*  Consensus sequence
In molecular biology and bioinformatics, the 'consensus sequence' is the calculated order of most frequent residues, either nucleotide or amino acid, found at each position in a sequence alignment. It represents the results of multiple sequence alignment s in which related sequences are compared to each other and similar sequence motifs are calculated. Biological significance Sequence analysis Notation. Thus a consensus sequence is a model for a putative DNA binding site : it is obtained by aligning all known examples of a certain recognition site and defined as the idealized sequence that represents the predominant base at each position. Any mutation allowing a mutated nucleotide in the core promoter sequence to look more like the consensus sequence is known as an 'up mutation'. On the contrary, mutations that destroy conserved nucleotides in the consensus sequence are known as 'down mutations'. These types of mutations down-regulate transcription since RNA polymerase can no longer bind as tightly to the cor...
https://en.wikipedia.org/wiki/Consensus_sequence
*  Publications | NEB
Proc.Natl.Acad.Sci.USA J Parasitol. Nature Structure Methods Mol.Biol. CABIOS Glycobiology Proceeding of the Heartworm Symposium Biotechnology Biochemistry Parasitology Today Science Archaea A Laboratory Manual Parasitology Proc Natl Acad Sci Clinical and Diagnostic Laboratory Immunology Abstracts Of Papers Of The American Chemical Society Accountability in Research Genetic Analysis Biomolecular Engineering Enzymes and Proteins from Hyperthermophilic Microorganisms, Advs.Protein Chemistry Genetics Society of America Nuc.Acids Res. Nucleic Acids Research BMC Res Notes J Steroid Biochem Mol Biol World J. Plant Cell Nature Chemistry Methods in Molecular Biology Mol Cell Biol. J Cell Sci BMC Microbiol Protein Cell Gene Ther Appl Microbiol Biotechnol Nat Biotechnol Front Physiol Appl Environ Microbiol Viruses Applications in Plant Sciences G3 Bethesda J Virol Anal Biochem AMB Express PLoS Pathog Curr Opin Chem Biol J Biol Eng Mol Biol Evol PLoS Genet Biology Basel Front Genet Curr Protoc Mol Biol Methods Mol Biol ...
https://neb.com/research/publications?num=100&sorting=Journal&asc=False
*  Bill Robinson to sit out 27 months - Harness Racing Newsroom - USTA - USTROTTING
... WHAT IS THE USTA. USTA. USTA Home. Rule Book. Rule Book PDF. Rule Change Proposals. Rule Change Proposals. Ask the USTA. This Is Harness Racing. A Winning Combination. Rule Book. Rule Book PDF. Rule Change Proposals. Stakes Guide. Stakes Event Guide. USTA Youth. HORSE SERVICES. Racing Entries/Results. Racing Home. TrackMaster Race Programs. Bill Robinson to sit out 27 months Tuesday, April 20, 2004 - by Harness Racing Communications, a division of the USTA Tweet. Trainer Bill Robinson will serve suspensions totaling 27 months and pay fines totaling C$125,000 under an agreement with the Ontario Racing Commission announced Tuesday by the ORC. On April 16, the Ontario Superior Court of Justice Divisional Court dismissed Robinson's application for judicial review regarding a C$50,000 fine and 10-month suspension because of a positive Class III drug test on the horse Artistic. Robinson served approximately four months of the suspension for the Artistic ruling, and will serve another six months and one week un...
http://xwebapp.ustrotting.com/absolutenm/templates/article.aspx?articleid=2247&zoneid=1
*  Publications | NEB
Proc.Natl.Acad.Sci.USA J Parasitol. Proteins Mol.Cell.Biol. CABIOS Glycobiology Proceeding of the Heartworm Symposium Biotechnology Biochemistry Parasitology Today Science Archaea A Laboratory Manual Parasitology Proc Natl Acad Sci Clinical and Diagnostic Laboratory Immunology Abstracts Of Papers Of The American Chemical Society Accountability in Research Genetic Analysis Biomolecular Engineering Enzymes and Proteins from Hyperthermophilic Microorganisms, Advs.Protein Chemistry Genetics Society of America Nuc.Acids Res. J Bacteriol Biotechnology Journal Biomedical Optics Express Nucleic Acids Res. Plant Cell Nature Chemistry Methods in Molecular Biology Mol Cell Biol. J Cell Sci BMC Microbiol Protein Cell Gene Ther Appl Microbiol Biotechnol Nat Biotechnol Front Physiol Appl Environ Microbiol Viruses Applications in Plant Sciences G3 Bethesda J Virol Anal Biochem AMB Express PLoS Pathog Curr Opin Chem Biol J Biol Eng Mol Biol Evol PLoS Genet Biology Basel Front Genet Curr Protoc Mol Biol Methods Mol Biol Eur J...
https://neb.com/research/publications?Page=32&sorting=Journal&asc=False
*  SMART: CDC37 C domain annotation
smart cdc c domain annotation smart mode normal genomic schultz et al proc natl acad sci usa letunic et al nucleic acids res doi nar gku home setup faq about glossary what s new feedback cdc c cdc c terminal domain smart accession number sm description cdc is a protein required for the activity of numerous eukaryotic protein kinases this domains corresponds to the c terminal domain whose function is unclear it is found c terminal to the hsp chaperone heat shocked protein binding domain pf and the n terminal kinase binding domain of cdc pubmed interpro abstract ipr cdc is a protein required for the activity of numerous eukaryotic protein kinases this entry corresponds to the c terminal domain whose function is unclear it is found c terminal to the hsp chaperone heat shock protein binding domain ipr and the n terminal kinase binding domain of cdc ipr family alignment view or chroma format clustalw format msf format fasta format pir format there are cdc c domains in proteins in smart s nrdb database click on the...
http://smart.embl-heidelberg.de/smart/do_annotation.pl?ACC=SM01069&BLAST=DUMMY
*  Nucleotide (Weighted) Links for PubMed (Select 17242370) - Nucleotide - NCBI
Nucleotide Weighted Links for PubMed Select 17242370 - Nucleotide - NCBI. NCBI. BLAST Basic Local Alignment Search Tool. GenBank. BLAST Basic Local Alignment Search Tool. Search database All Databases Assembly BioProject BioSample BioSystems Books ClinVar Clone Conserved Domains dbGaP dbVar Epigenomics EST Gene Genome GEO DataSets GEO Profiles GSS GTR HomoloGene MedGen MeSH NCBI Web Site NLM Catalog Nucleotide OMIM PMC PopSet Probe Protein Protein Clusters PubChem BioAssay PubChem Compound PubChem Substance PubMed PubMed Health SNP SRA Structure Taxonomy ToolKit ToolKitAll ToolKitBook UniGene Search term. Format Summary GenBank GenBank full FASTA ASN.1 XML INSDSeq XML TinySeq XML Feature Table Accession List GI List. Sort by Default order Accession Date Modified Date Released Organism Name Taxonomy ID. Mus musculus guanine nucleotide binding protein G protein, alpha inhibiting 2 Gnai2, mRNA. Mus musculus adult inner ear cDNA, RIKEN full-length enriched library, clone:F930015A20 product:guanine nucleotide bind...
http://ncbi.nlm.nih.gov/nuccore?LinkName=pubmed_nuccore_weighted&from_uid=17242370
*  LARGE POOL SIZE
... Oracle Forums. Oracle Database Administration. LARGE POOL SIZE. Thread: LARGE POOL SIZE. View Profile. View Forum Posts. i want to know how these large pool will use in ORACLE. Reply With Quote. View Profile. View Forum Posts. Senior Advisor. You can size the large pool with LARGE POOL SIZE LARGE POOL MIN ALLOC parameters in init.ora If the size is 0, the large pool is not set. Reply With Quote. View Profile. View Forum Posts. Reply With Quote. View Profile. View Forum Posts. Join Date May 2000 Location ATLANTA, GA, USA Posts 3,135. LARGE POOL SIZE does not improve I/O slave processes. If this area is set, then it will be used for PL/SQL procedures. In general, 10 % of SHARED POOL SIZE is set for this parameter. Reply With Quote. View Profile. View Forum Posts. Originally posted by tamilselvan LARGE POOL SIZE does not improve I/O slace processes. If this area is set, then it will be used for PL/SQL procedures. In general, 10 % of SHARED POOL SIZE is set for this parameter. Large pool is not a part of SHA...
http://dbasupport.com/forums/showthread.php?16303-LARGE_POOL_SIZE&p=65753
*  Olson family statement, 1975
... The Frank Olson. Legacy Project. FAMILY STATEMENT, 1975. FAMILY STATEMENT BY THE WIFE AND CHILDREN OF FRANK R. OLSON Alice Wicks Olson Eric Wicks Olson Lisa Wicks Olson Hayward Nils Wicks Olson Released in a press conference July 10, 1975. We are the family of Frank R. Olson. Frank Olson a civilian biochemist working for the United States Army died shortly after midnight on November 28, 1953, when he plunged to his death from a window on the 10th floor of the Hotel Statler in New York. The death certificate states that Frank Olson jumped or fell and cites multiple fractures, shock and hemorrhage as the causes of death. An employee of the Central Intelligence Agency had been with Frank Olson in his hotel room the night he died. This man was accompanying Frank Olson in his hotel room the night he died. This man was accompanying Frank Olson when Olson was taken to New York to consult a psychiatrist. Olson s widow was later told that her husband s escort had awakened about 1:30 A.M. to see Olson going at a f...
http://frankolsonproject.org/Statements/FamilyStatement1975.html
*  Search results for query PF00558 - Protein Data Bank Japan
PDB: 9 results Info pages: 0 results Status search: 0 results Chemie search: 0 results ✖. STRUCTURE OF THE CHANNEL-FORMING TRANS-MEMBRANE DOMAIN OF VIRUS PROTEIN "U" VPU FROM HIV-1. Authors: Park, S.H., Mrse, A.A., Nevzorov, A.A., Mesleh, M.F., Oblatt-Montal, M., Montal, M., Opella, S.J. Cite: Three-dimensional structure of the channel-forming trans-membrane domain of virus protein "u" Vpu from HIV-1 J.Mol.Biol., 333, 2003. STRUCTURE OF THE CHANNEL-FORMING TRANS-MEMBRANE DOMAIN OF VIRUS PROTEIN "U" VPU FROM HIV-1. Authors: Park, S.H., Mrse, A.A., Nevzorov, A.A., Mesleh, M.F., Oblatt-Montal, M., Montal, M., Opella, S.J. Cite: Three-dimensional structure of the channel-forming trans-membrane domain of virus protein "u" Vpu from HIV-1 J.Mol.Biol., 333, 2003. STRUCTURE OF THE CHANNEL-FORMING TRANS-MEMBRANE DOMAIN OF VIRUS PROTEIN "U" VPU FROM HIV-1. Authors: Park, S.H., Mrse, A.A., Nevzorov, A.A., Mesleh, M.F., Oblatt-Montal, M., Montal, M., Opella, S.J. Cite: Three-dimensional structure of the channel-forming tr...
http://pdbj.org/mine/search?query=PF00558
*  SCOP: Protein: Class II MHC beta chain, C-terminal domain from Human (Homo sapiens), HLA-DR group [T
SCOP: Protein: Class II MHC beta chain, C-terminal domain from Human Homo sapiens , HLA-DR group. Structural Classification of Proteins Protein: Class II MHC beta chain, C-terminal domain from Human Homo sapiens , HLA-DR group. Lineage: Root: scop Class: All beta proteins Fold: Immunoglobulin-like beta-sandwich sandwich; 7 strands in 2 sheets; greek-key some members of the fold have additional strands Superfamily: Immunoglobulin uperfamily Family: C1 set domains antibody constant domain-like Protein: Class II MHC beta chain, C-terminal domain Species: Human Homo sapiens , HLA-DR group. SQ P04229 30-219 probably orthologous to the mouse I-E group PDB Entry Domains:. 1fv1. complexed with ace, nag region b:93-190. complexed with ace; mutant region b:93-190. automatically matched to d1bx2b1 region b:93-190. automatically matched to d1d5xb1 complexed with dio, epe, so4, zn region b:93-190. automatically matched to d1d5xb1 complexed with 4dp, ace; mutant region b:93-190. mutant region b:93-190. mutant region b:93-1...
http://scop.mrc-lmb.cam.ac.uk/scop/data/scop.b.c.b.b.c.gg.html
*  Genetic regulatory mechanisms and carcinogenesis.
... Enter Your Search: Search tips Search criteria Articles Journal titles. Public Health Rep. Page Browse. Bates, R. Public Health Rep. PMCID: PMC1919899. Genetic regulatory mechanisms and carcinogenesis. H V Gelboin and R. Bates. Full text Full text is available as a scanned copy of the original print version. Links to PubMed are also available for Selected References. Selected References. These references are in PubMed. Mammary cancer induced by a single feeding of polymucular hydrocarbons, and its suppression. Cancer Res. 1958 Jul; 18 6 :725–729. Cancer Res. 1962 Jun; 22 :525–548. J Natl Cancer Inst. 1957 Jun; 18 6 :769–778. Cancer Res. IDENTITY OF DNA AND DIVERSITY OF MESSENGER RNA MOLECULES IN NORMAL MOUSE TISSUES. Proc Natl Acad Sci U S A. 1964 Oct; 52 :915–922. THE CYCLIC HELIX AND CYCLIC COIL FORMS OF POLYOMA VIRAL DNA. Proc Natl Acad Sci U S A. 1963 Oct; 50 :730–738. Proc Natl Acad Sci U S A. Proc Natl Acad Sci U S A. V Evidence for induction of enzyme synthesis in the rat by 3-methylcholanthrene. ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC1919899/
*  Maps: pUC18, pUC19 DNA
Home Contacts Order Catalog Support. pUC18, pUC19 pUC18. GenBank/EMBL sequence accession number L09136. pUC19. GenBank/EMBL sequence accession number L09137. Restriction sites of the pUC18 DNA Please note that the pUC19 nt sequence deposited under EMBL accession number X02514 is exactly the same as L09137 GenBank/EMBL, while X02514 GenBank has two errors. CAP protein binding site 591-554 compl. lac repressor binding site 507-487 compl. pUC18 and pUC19 vectors are small, high copy number, E.coli plasmids, 2686 bp in length. pUC18/19 plasmids contain: 1 the pMB1 replicon rep responsible for the replication of plasmid source plasmid pBR322. The high copy number of pUC plasmids is a result of the lack of the rop gene and a single point mutation in rep of pMB1; 2 bla gene, coding for beta-lactamase that confers resistance to ampicillin source plasmid pBR322. It differs from that of pBR322 by two point mutations; 3 region of E.coli operon lac containing CAP protein binding site, promoter Plac, lac repressor binding...
http://dwb4.unl.edu/Chem/CHEM869N/CHEM869NLinks/fermentas.com/TechInfo/NucleicAcids/MappUC1819.htm
*  Tetracyclin repressor-like, C-terminal domain superfamily
Biological Process BP regulation of RNA metabolic process 0.0008117 1.109 -- DIRECT. Biological Process BP regulation of RNA biosynthetic process 0.00000000001558 1.154 -- DIRECT. Biological Process BP regulation of macromolecule metabolic process 0.1063 0.7873 -- INHERITED FROM : regulation of RNA metabolic process |. Biological Process BP regulation of metabolic process 0.00002713 0.6426 Least Informative DIRECT. Biological Process BP regulation of macromolecule biosynthetic process 0.0007777 1.059 Moderately Informative DIRECT. Biological Process BP regulation of cellular biosynthetic process 0.0335 0.9894 Moderately Informative INHERITED FROM : regulation of cellular macromolecule biosynthetic process |. Biological Process BP regulation of nucleobase-containing compound metabolic process 0.01401 0.9736 Moderately Informative INHERITED FROM : regulation of RNA metabolic process |. Molecular Function MF molecular_function 1 0 -- INHERITED FROM : nucleic acid binding |. Molecular Function MF binding 0.4364 0...
http://supfam.cs.bris.ac.uk/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48498
*  PlantTFDB - Plant Transcription Factor Databases @ CBI, PKU
bHLH Family Introduction The basic/helix-loop-helix bHLH proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that th...
http://planttfdb.cbi.pku.edu.cn/family.php?fam=bHLH
*  .. [UPDATE] R. Kelly Hospitalized Due to ‘Strange Illness’ .. ************************** .. Oh
R. Kelly Hospitalized Due to ‘Strange Illness’. June 27th, 2012, lilD. . UPDATE. R Kelly’s people have said, “Initial indications are that he is suffering from complications from surgery he had last year to treat an abscess on his vocal cords.”. Because of said illness, Kells has had to cancel appearances on both the “Jimmy Fallon Show” and NBC’s “Today Show.”. His reps added: “It is unclear how long Kelly may be sidelined.”. The Wheard: TMZ. **************************. Aww man…and just when he was getting ready to launch his book tour. Did I so sund like I care…. Anywho, R. Kelly has been hospitalized due to some “strange illness,” so he’s had to postpone his album launching party in New York. One of R. Kellly’s reps said the date was postponed  “due to a health emergency that has sidelined Mr. Kelly in Chicago.”  No other information at this time. Wonder if it’s his voice. Remember when had that surgery when he lost his voice. Hmm…. The Wheard: Complex. I’m lilD, and that’s the Word Eye Heard. So many ...
http://thewordeyeheard.com/2012/06/27/r-kelly-hospitalized-due-to-strange-illness/
*  eIF-2-alpha, C-terminal domain superfamily
... Home > SCOP hierarchy > eIF-2-alpha, C-terminal domain superfamily. SEARCH Keyword search. Sequence search. BROWSE Organisms. Taxonomy. Statistics. SCOP. Hierarchy. Ontologies. GO. EC. Phenotype TOOLS Compare genomes. Phylogenetic trees. Web services. Downloads. ABOUT Description. Publications. Documentation HELP User support. Contact us. Email list. Sitemap. Structural Classification. Genome Assignments. Sequence Alignments. Domain Combinations. Taxonomic Distribution. eIF-2-alpha, C-terminal domain superfamily. SCOP classification Root: SCOP hierarchy in SUPERFAMILY 11. Class: Alpha and beta proteins a+b 376. Fold: Ferredoxin-like 59. Superfamily : eIF-2-alpha, C-terminal domain. Families: eIF-2-alpha, C-terminal domain. Superfamily statistics. Genomes 646 Uniprot 2014 06 PDB chains SCOP 1.75. Domains 757 1,028 3. Proteins 755 1,025 3. Functional annotation General category Information. Detailed category Translation. Document:. Function annotation of SCOP domain superfamilies. Gene Ontology high-covera...
http://supfam.cs.bris.ac.uk/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF110993
*  Dylan Bob Tabs - Just Like A Women Tabs (ver. 1)
Dylan Bob Tabs - Just Like A Women Tabs ver. 1 Home. D Dylan Bob. Dylan Bob, Just Like A Women Tabs ver.1. Artists: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #. Best songs All Of Me John Legend Love Me Like You Do Ellie Goulding Take Me To Church Hozier See You Again Wiz Khalifa Let Her Go Passenger Riptide Vance Joy Lay Me Down Sam Smith Stay With Me Sam Smith Four Five Seconds Rihanna Hallelujah Jeff Buckley. Follow us on. Just Like A Women Tabs ver.1. Dylan Bob Tabs. Rating: 4/ 5 4 votes. Versions:. Tabs. Chords. Version 1 4. ×. Print Tabs too difficult. Try these video lessons and learn fast. JUST LIKE A WOMAN by Bob Dylan C F G C Nobody feels any pain C F G C Tonight as I stand inside the rain F G F G Everybody knows that baby's got new clothes F Em Dm C F G But lately I see her ribbons and her bows Am C G Have fallen from her curls C Em F She takes just like a woman, yes she does C Em F She makes love just like a woman, yes she does C Em F And she aches just like a woman G C But she breaks jus...
http://azchords.com/d/dylanbob-tabs-5069/justlikeawomen-tabs-177242.html
*  James - ( Just Like Fred Astaire tab )
James - Just Like Fred Astaire tab. Just Like Fred Astaire tab. James tabs. Song name Band name Song name. # A B C D E F G H I J K L M N O P Q R S T U V W X Y Z. Home / J / James / Just Like Fred Astaire tab. Print this tab. Listen to Just Like Fred Astaire. James - Just Like Fred Astaire tab. Highlighted Show chord diagrams. Doctor, What is happening to me. Palpitations My mind's diseased Even my v ision is impaired I'm losing my hair Cos when I hold her in my arms I feel like Fred As taire Lovesick My temperature's high Just met a girl Who believes we can fly[ I'm A millionaire .. And when I hold her in my arms I feel like Fred As taire. I believe in happiness I believe in Love I believe she fell to earth from somewhere high above I believe in Hollywood Don't believe that Love must bring despa ir Cos when I hold her in my arms I'm just like Fred Astaire He said love is just a disease A plague for the na ive These days no one be lieves Meteors may strike the earth Nations live and die I'm the boy who got the...
http://guitaretab.com/j/james/40110.html
*  [Bioperl-l] Degenerate primer calculation
Degenerate primer calculation. Degenerate primer calculation Samantha Thompson Samantha.Thompson at greenbiologics.com. Previous message: Degenerate primer calculation Next message: About to tag the last RC... Messages sorted by:. -----Original Message----- From: Sara Kalla Sent: 12 January 2009 20:10 To: Samantha Thompson Cc: bioperl-l List Subject: Re: Degenerate primer calculation Samantha Thompson wrote: -----Original Message----- From: Chris Fields. Sent: 08 December 2008 16:41 To: Samantha Thompson Cc: bioperl-l List Subject: Re: Degenerate primer calculation. On Dec 8, 2008, at 9:59 AM, Samantha Thompson wrote: Hi, I also have another similar sequence analysis/primer problem. What I'd like to do is produce degenerate primers from amino acid sequences. amino acid sequence derived as a consensus from multiple the alignment of homologous proteins and converts them into degenerate codons and then that degenerate primer actually several primers synthesised with different bases pooled together, in order to s...
http://bioperl.org/pipermail/bioperl-l/2009-January/028912.html
*  .. SmokeyRobinson .. Smokey Robinson & The Miracles Co-Founder Bobby Rogers Dead at Age 73 .. Presi
SmokeyRobinson SmokeyRobinson. Tags: bobby rogers, bobby rogers dead, bobby rogers rip, bobby rogers smokey robinson, BobbyRogers, BobbyRogersDead, BobbyRogersRip, BobbyRogersSmokeyRobinson, Smokey Robinson, smokey robinson the miracles, SmokeyRobinson, SmokeyRobinsonTheMiracles, smokeyrobison, smoky robinson, smokyrobinson. Share on Tumblr. President Obama Inauguration: Usher, Alicia Keys, Stevie Wonder More to Perform. Category: Hip-Hop Tags: Alicia Keys, Alicia Keys Obama, AliciaKeysObama, inauguration, John Legend, John Legend Obama, JohnLegend, JohnLegendObama, Obama, Obama Inauguration, ObamaInauguration, Smoke Robinson Obama, SmokeRobinsonObama, Smokey Robinson, SmokeyRobinson, Stevie Wonder, Stevie Wonder Obama, StevieWonder, StevieWonderObama, Usher, Usher Obama, UsherObama. Send to a friend. Share on Tumblr. Share on Tumblr. Share on Tumblr. Tags: berry gordy, BerryGordy, Queen Latifah, QueenLatifah, Smokey Robinson, SmokeyRobinson, Stevie Wonder, StevieWonder, Teena Marie, TeenaMarie. Share on Tumb...
http://theboombox.com/tags/SmokeyRobinson/
*  Products Archives - Phillips Pet Food & Supplies - Phillips Pet Food & Supplies
Products Archives - Phillips Pet Food Supplies - Phillips Pet Food Supplies. Products. Vendors. Events. Phillips News. Industry News. Vendors Customers Online Store. Products. Products. Eshopps 3rd Generation Sumps and Refugiums Posted on 8/5/15 by Emma Godfrey Newly designed for your tank come the Ehsopps 3rd Generation sumps and refugiums. The Eshopps 3rd Generation Reef Sump is extremely quiet, even virtually silent during operation due to the spill-over design in the micron bag compartment. It is designed for reef tanks, and its ease of installation makes it perfect for both beginner and Continue Reading. Products. The RAWZ Difference Posted on 7/31/15 by Emma Godfrey If you’re seeking a dog or cat food that does things differently, consider the new RAWZ kibble. RAWZ cat and dog food contains no rendered meals or processed ingredients, and its only protein source is dehydrated chicken. RAWZ chicken is steamed at low Continue Reading. Products. Walk In Comfort with Wigzi Gel Leashes Posted on 7/17/15 by Em...
http://phillipspet.com/category/products/
*  Patent US5158935 - Human epidermal growth factor having substitution at position 11 - Google Patents
We have now found that one may improve the storage life of EGF without diminishing its biological activity by replacing the Asp at position 11 with a different amino acid, preferably Glu, Asn, Gln, Ala, or Lys, more preferably Glu, or Asn, and most preferably Glu. Human epidermal growth factor having substitution at position 11 US 5158935 A Abstract We have now found that one may improve the storage life of EGF without diminishing its biological activity by replacing the Asp at position 11 with a different amino acid, preferably Glu, Asn, Gln, Ala, or Lys, more preferably Glu, or Asn, and most preferably Glu. The amino acid sequence of human EGF is: Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys Trp Trp Glu Leu Arg This sequence was published by H. Murine EGF has the sequence differences from hEGF underlined : Asn Ser Tyr Pro Gly Cys Pro Ser Ser Tyr Asp Gly Tyr Cys L...
http://google.com/patents/US5158935?dq=7,446,777
*  Protein–DNA interaction site predictor
... Characteristics of such binding sites may be used for predicting DNA-binding sites from the structural and even sequence properties of unbound proteins. First attempt to use sequence and evolutionary features to predict DNA-binding sites in proteins was made by Ahmad et al. It is based on the chemical-physical properties of the residue and its environment, predicted structural features and evolutionary data. Prediction of DNA-binding residues from sequence Bioinformatics 23 13 :i347-53 2007. 3 'DNABindR' predicts DNA binding sites from amino acid sequences using machine learning algorithms. Predicting DNA-binding sites of proteins from amino acid sequence. "BindN: a web-based tool for efficient prediction of DNA and RNA binding sites in amino acid sequences." Nucleic Acids Research. 6 'BindN+', an upgraded version of BindN, applies support vector machine s SVMs to sequence-based prediction of DNA or RNA-binding residues from biochemical features and evolutionary information. "DP-Bind: a web server for se...
https://en.wikipedia.org/wiki/Protein–DNA_interaction_site_predictor
*  Rocky Patel Cigars | Gotham Cigars
Rocky Patel Cigars. Gotham Cigars. My Cart. Your cart is currently empty. Compare 0 There are no items selected for comparison. Compare Items. ACID. Alec Bradley. Arturo Fuente. Ashton Classic. CAO. Cohiba. Cuesta Rey. Don Diego. Gurkha. Macanudo. Montecristo. Oliva. Padron. Partagas. Playboy By Don Diego. Rocky Patel. Romeo Y Julieta. Acid Cigarillos. Phillies. Swisher Sweets. In 2003, Rocky Patel debuted the Rocky Patel Vintage Series of cigars into the premium handmade cigar market. Discount Rocky Patel Cigars from Gotham Cigars GothamCigars.com is your dedicated online cigar center, and we are proud to offer you a full selection of award winning cigars made by Rocky Patel at the lowest prices around. This includes the legendary Rocky Patel Vintage series, Rocky Patel Sun Grown cigars, and the vaunted Rocky Patel Decade cigars. Gotham Cigars offers you all the best cigars made by Rocky Patel at prices that just might surprise you. A longstanding favorite, Rocky Patel Sun Grown cigars are very full bodied a...
https://gothamcigars.com/rocky-patel-cigars/?cat=525&length=145&package_type=41
*  Rocky Patel Cigars | Gotham Cigars
Rocky Patel Cigars. Gotham Cigars. My Cart. Your cart is currently empty. Compare 0 There are no items selected for comparison. Compare Items. ACID. Alec Bradley. Arturo Fuente. Ashton Classic. CAO. Cohiba. Cuesta Rey. Don Diego. Gurkha. Macanudo. Montecristo. Oliva. Padron. Partagas. Playboy By Don Diego. Rocky Patel. Romeo Y Julieta. Acid Cigarillos. Phillies. Swisher Sweets. In 2003, Rocky Patel debuted the Rocky Patel Vintage Series of cigars into the premium handmade cigar market. Discount Rocky Patel Cigars from Gotham Cigars GothamCigars.com is your dedicated online cigar center, and we are proud to offer you a full selection of award winning cigars made by Rocky Patel at the lowest prices around. This includes the legendary Rocky Patel Vintage series, Rocky Patel Sun Grown cigars, and the vaunted Rocky Patel Decade cigars. Gotham Cigars offers you all the best cigars made by Rocky Patel at prices that just might surprise you. A longstanding favorite, Rocky Patel Sun Grown cigars are very full bodied a...
https://gothamcigars.com/rocky-patel-cigars/?cat=527&length=146&mode=list&shape=76
*  Rocky Patel Cigars | Gotham Cigars
Rocky Patel Cigars. Gotham Cigars. My Cart. Your cart is currently empty. Compare 0 There are no items selected for comparison. Compare Items. ACID. Alec Bradley. Arturo Fuente. Ashton Classic. CAO. Cohiba. Cuesta Rey. Don Diego. Gurkha. Macanudo. Montecristo. Oliva. Padron. Partagas. Playboy By Don Diego. Rocky Patel. Romeo Y Julieta. Acid Cigarillos. Phillies. Swisher Sweets. In 2003, Rocky Patel debuted the Rocky Patel Vintage Series of cigars into the premium handmade cigar market. Discount Rocky Patel Cigars from Gotham Cigars GothamCigars.com is your dedicated online cigar center, and we are proud to offer you a full selection of award winning cigars made by Rocky Patel at the lowest prices around. This includes the legendary Rocky Patel Vintage series, Rocky Patel Sun Grown cigars, and the vaunted Rocky Patel Decade cigars. Gotham Cigars offers you all the best cigars made by Rocky Patel at prices that just might surprise you. A longstanding favorite, Rocky Patel Sun Grown cigars are very full bodied a...
https://gothamcigars.com/rocky-patel-cigars/?cat=527&length=146&p=2&shape=76
*  Rocky Patel Cigars | Gotham Cigars
Rocky Patel Cigars. Gotham Cigars. My Cart. Your cart is currently empty. Compare 0 There are no items selected for comparison. Compare Items. ACID. Alec Bradley. Arturo Fuente. Ashton Classic. CAO. Cohiba. Cuesta Rey. Don Diego. Gurkha. Macanudo. Montecristo. Oliva. Padron. Partagas. Playboy By Don Diego. Rocky Patel. Romeo Y Julieta. Acid Cigarillos. Phillies. Swisher Sweets. In 2003, Rocky Patel debuted the Rocky Patel Vintage Series of cigars into the premium handmade cigar market. Discount Rocky Patel Cigars from Gotham Cigars GothamCigars.com is your dedicated online cigar center, and we are proud to offer you a full selection of award winning cigars made by Rocky Patel at the lowest prices around. This includes the legendary Rocky Patel Vintage series, Rocky Patel Sun Grown cigars, and the vaunted Rocky Patel Decade cigars. Gotham Cigars offers you all the best cigars made by Rocky Patel at prices that just might surprise you. A longstanding favorite, Rocky Patel Sun Grown cigars are very full bodied a...
https://gothamcigars.com/rocky-patel-cigars/?cat=527&p=2&price=150-&shape=76
*  Rocky Patel Cigars | Gotham Cigars
Rocky Patel Cigars. Gotham Cigars. My Cart. Your cart is currently empty. Compare 0 There are no items selected for comparison. Compare Items. ACID. Alec Bradley. Arturo Fuente. Ashton Classic. CAO. Cohiba. Cuesta Rey. Don Diego. Gurkha. Macanudo. Montecristo. Oliva. Padron. Partagas. Playboy By Don Diego. Rocky Patel. Romeo Y Julieta. Acid Cigarillos. Phillies. Swisher Sweets. In 2003, Rocky Patel debuted the Rocky Patel Vintage Series of cigars into the premium handmade cigar market. Discount Rocky Patel Cigars from Gotham Cigars GothamCigars.com is your dedicated online cigar center, and we are proud to offer you a full selection of award winning cigars made by Rocky Patel at the lowest prices around. This includes the legendary Rocky Patel Vintage series, Rocky Patel Sun Grown cigars, and the vaunted Rocky Patel Decade cigars. Gotham Cigars offers you all the best cigars made by Rocky Patel at prices that just might surprise you. A longstanding favorite, Rocky Patel Sun Grown cigars are very full bodied a...
https://gothamcigars.com/rocky-patel-cigars/?cat=533&p=2&package_type=504&wrapper_color=81
*  Rocky Patel Cigars | Gotham Cigars
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*  [Bioperl-l] Degenerate primer calculation
Degenerate primer calculation. Degenerate primer calculation Chris Fields cjfields at illinois.edu. Mon Dec 8 11:41:04 EST 2008. Previous message: Degenerate primer calculation Next message: Degenerate primer calculation Messages sorted by:. On Dec 8, 2008, at 9:59 AM, Samantha Thompson wrote: Hi, I also have another similar sequence analysis/primer problem. What I'd like to do is produce degenerate primers from amino acid sequences. What I did initially was take the codon usage table and rewrite it. in a hash in perl in the form of degenerate codon usage e.g Lysine/K. would be AAR, its reverse complement would be YTT. So my form then takes an. amino acid sequence derived as a consensus from multiple the alignment of homologous proteins and converts them into degenerate codons and then that degenerate primer actually several primers synthesised with different bases pooled together, in order to search for homologues to the protein in unsequenced organisms. I would like to improve this by being able to take a c...
http://bioperl.org/pipermail/bioperl-l/2008-December/028650.html
*  Revision history of "User:Dhea Patel/Notebook/Hemoglobin Project/2013/06/11" - OpenWetWare
Revision history of User:Dhea Patel/Notebook/Hemoglobin Project/2013/06/11 - OpenWetWare. Revision history of User:Dhea Patel/Notebook/Hemoglobin Project/2013/06/11 From OpenWetWare View logs for this page Jump to: navigation, search Latest. Earliest View newer 50 older 50 20. 50. 100. 250. 500 Diff selection: mark the radio boxes of the versions to compare and hit enter or the button at the bottom. Legend: cur = difference with current version, last = difference with preceding version, M = minor edit. cur last. 12:05, 8 July 2013. Dhea Patel Talk. contribs. m 2,036 bytes cur last. 12:03, 8 July 2013. Dhea Patel Talk. contribs. m 2,036 bytes cur last. 16:08, 11 June 2013. Dhea Patel Talk. contribs. m 2,012 bytes cur last. 13:33, 11 June 2013. Dhea Patel Talk. contribs. m 1,804 bytes cur last. 12:18, 11 June 2013. Dhea Patel Talk. contribs. m 1,786 bytes. → Data. cur last. 12:11, 11 June 2013. Dhea Patel Talk. contribs. 1,740 bytes. → Data. cur last. 12:10, 11 June 2013. Dhea Patel Talk. contribs. m 1,739 byte...
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*  Homo sapiens guanine nucleotide binding protein (G protein) cDNA clone - GenScript
Homo sapiens guanine nucleotide binding protein G protein cDNA clone - GenScript. English US. 日本語 http://www.genscript.jp. Place Order. My Cart. Contact. Reward Center. Services. Close. Gene Services. Gene Synthesis. GenPlus™ Next-Gen HT Gene Synthesis. GenBrick Long Gene Synthesis. Express Gene Synthesis. ORF cDNA Clones and Custom Clones. Gene Variant Libraries. Plasmid DNA Preparation. DNA/RNA Oligos. DNA Sequencing. CRISPR Services. gRNA Cas9 plasmids. GeCKO libraries. SAM libraries. Genome-edited cell lines. Microbial genome editing. Peptide Services. Peptide Synthesis. Peptide Library. Peptide Array. Large-Scale Peptide Synthesis. Cosmetic Peptide Synthesis. cGMP Peptide Synthesis. Click Peptide Synthesis. Peptoid Synthesis. Antibody Drug Development Services. Premium Hybridoma Development. Antibody Library & Phage Display. DNA Immunization. Camelid Single Domain Antibodies. Recombinant Antibody Production. Anti-idiotypic Antibodies. Protein Services. Bacterial Expression. Insect Ex...
http://genscript.com/cgi-bin/orf/refseq.pl?acc=NM_006572
  • 1

Q-FISH: Quantitative Fluorescent in situ hybridization (Q-FISH) is a cytogenetic technique based on the traditional FISH methodology. In Q-FISH, the technique uses labelled (Cy3 or FITC) synthetic DNA mimics called peptide nucleic acid (PNA) oligonucleotides to quantify target sequences in chromosomal DNA using fluorescent microscopy and analysis software.Coles PhillipsProtein primary structure: The primary structure of a peptide or protein is the linear sequence of its amino acid structural units, and partly comprises its overall biomolecular structure. By convention, the primary structure of a protein is reported starting from the amino-terminal (N) end to the carboxyl-terminal (C) end.Symmetry element: A symmetry element is a point of reference about which symmetry operations can take place. In particular, symmetry elements can be centers of inversion, axes of rotation and mirror planes.Ligation-independent cloning: Ligation-independent cloning (LIC) is a form of molecular cloning that is able to be performed without the use of restriction endonucleases or DNA ligase. This allows genes that have restriction sites to be cloned without worry of chopping up the insert.Nucleic acid structure: Nucleic acid structure refers to the structure of nucleic acids such as DNA and RNA. Chemically speaking, DNA and RNA are very similar.DNA condensation: DNA condensation refers to the process of compacting DNA molecules in vitro or in vivo. Mechanistic details of DNA packing are essential for its functioning in the process of gene regulation in living systems.Polymethine: Polymethines are compounds made up from an odd number of methine groups (CH) bound together by alternating single and double bonds.Kachovski and Dekhtyar, Dyes and Pigments, 22 (1983) 83-97 Compounds made up from an even number of methine groups are known as polyenes.CS-BLASTPolymerase-endonuclease amplification reaction: Polymerase-endonuclease amplification reaction (PEAR) is a DNA amplification technology for the amplification of oligonucleotides. A target oligonucleotide and a tandem repeated antisense probe are subjected to repeated cycles of denaturing, annealing, elongation and cleaving, in which thermostable DNA polymerase elongation and strand slipping generate duplex tandem repeats, and thermostable endonuclease (PspGI) cleavage releases monomeric duplex oligonucleotides.YjdF RNA motifHyperchromicity: Hyperchromicity is the increase of absorbance (optical density) of a material. The most famous example is the hyperchromicity of DNA that occurs when the DNA duplex is denatured.List of strains of Escherichia coli: Escherichia coli is a well studied bacterium that was first identified by Theodor Escherich, after whom it was later named.Reaction coordinateDNA binding site: DNA binding sites are a type of binding site found in DNA where other molecules may bind. DNA binding sites are distinct from other binding sites in that (1) they are part of a DNA sequence (e.Restriction fragment: A restriction fragment is a DNA fragment resulting from the cutting of a DNA strand by a restriction enzyme (restriction endonucleases), a process called restriction. Each restriction enzyme is highly specific, recognising a particular short DNA sequence, or restriction site, and cutting both DNA strands at specific points within this site.Triparental mating: Triparental mating is a form of Bacterial conjugation where a conjugative plasmid present in one bacterial strain assists the transfer of a mobilizable plasmid present in a second bacterial strain into a third bacterial strain. Plasmids are introduced into bacteria for such purposes as transformation, cloning, or transposon mutagenesis.DNA sequencer: A DNA sequencer is a scientific instrument used to automate the DNA sequencing process. Given a sample of DNA, a DNA sequencer is used to determine the order of the four bases: G (guanine), C (cytosine), A (adenine) and T (thymine).Abscription: During normal transcription, RNA polymerase transcribes a number of short nonproductive oligonucleotides, and this process is called abortive transcription. The trapped RNAPs have been named abscriptases and the synthesis of specific length oligonucleotides called abscription.Thermal cyclerFERM domain: In molecular biology, the FERM domain (F for 4.1 protein, E for ezrin, R for radixin and M for moesin) is a widespread protein module involved in localising proteins to the plasma membrane.Mature messenger RNA: Mature messenger RNA, often abbreviated as mature mRNA is a eukaryotic RNA transcript that has been spliced and processed and is ready for translation in the course of protein synthesis. Unlike the eukaryotic RNA immediately after transcription known as precursor messenger RNA, it consists exclusively of exons, with all introns removed.Proximity ligation assay: Proximity ligation assay (in situ PLA) is a technology that extends the capabilities of traditional immunoassays to include direct detection of proteins, protein interactions and modifications with high specificity and sensitivity. Protein targets can be readily detected and localized with single molecule resolution and objectively quantified in unmodified cells and tissues.MIPModDB: MIPModDB is a database of comparative protein structure models of MIP (Major intrinsic proteins) family of proteins.Ferric uptake regulator family: In molecular biology, the ferric uptake regulator (FUR) family of proteins includes metal ion uptake regulator proteins. These are responsible for controlling the intracellular concentration of iron in many bacteria.Branching order of bacterial phyla (Gupta, 2001): There are several models of the Branching order of bacterial phyla, one of these was proposed in 2001 by Gupta based on conserved indels or protein, termed "protein signatures", an alternative approach to molecular phylogeny. Some problematic exceptions and conflicts are present to these conserved indels, however, they are in agreement with several groupings of classes and phyla.Src homology domain: In biology, a Src homology domain is one of the two small protein binding domains found in the Src oncoprotein. Homologs of both the Src homology 2 and Src homology 3 domains are found in numerous other proteins.Database of protein conformational diversity: The Database of protein conformational diversity (PCDB) is a database of diversity of protein tertiary structures within protein domains as determined by X-ray crystallography. Proteins are inherently flexible and this database collects information on this subject for use in molecular research.Eukaryotic transcription: Eukaryotic transcription is the elaborate process that eukaryotic cells use to copy genetic information stored in DNA into units of RNA replica. Gene transcription occurs in both eukaryotic and prokaryotic cells.Molar mass distribution: In linear polymers the individual polymer chains rarely have exactly the same degree of polymerization and molar mass, and there is always a distribution around an average value. The molar mass distribution (or molecular weight distribution) in a polymer describes the relationship between the number of moles of each polymer species (Ni) and the molar mass (Mi) of that species.Open reading frame: In molecular genetics, an open reading frame (ORF) is the part of a reading frame that has the potential to code for a protein or peptide. An ORF is a continuous stretch of codons that do not contain a stop codon (usually UAA, UAG or UGA).Silent mutation: Silent mutations are mutations in DNA that do not significantly alter the phenotype of the organism in which they occur. Silent mutations can occur in non-coding regions (outside of genes or within introns), or they may occur within exons.Lattice protein: Lattice proteins are highly simplified computer models of proteins which are used to investigate protein folding.Library (biology): In molecular biology, a library is a collection of DNA fragments that is stored and propagated in a population of micro-organisms through the process of molecular cloning. There are different types of DNA libraries, including cDNA libraries (formed from reverse-transcribed RNA), genomic libraries (formed from genomic DNA) and randomized mutant libraries (formed by de novo gene synthesis where alternative nucleotides or codons are incorporated).Direct repeat: Direct repeats are a type of genetic sequence that consists of two or more repeats of a specific sequence.Specificity constant: In the field of biochemistry, the specificity constant (also called kinetic efficiency or k_{cat}/K_{M}), is a measure of how efficiently an enzyme converts substrates into products. A comparison of specificity constants can also be used as a measure of the preference of an enzyme for different substrates (i.Burst kinetics: Burst kinetics is a form of enzyme kinetics that refers to an initial high velocity of enzymatic turnover when adding enzyme to substrate. This initial period of high velocity product formation is referred to as the "Burst Phase".ParaHox: The ParaHox gene cluster is an array of homeobox genes (involved in morphogenesis, the regulation of patterns of anatomical development) from the Gsx, Xlox (Pdx) and Cdx gene families.Allele-specific oligonucleotide: An allele-specific oligonucleotide (ASO) is a short piece of synthetic DNA complementary to the sequence of a variable target DNA. It acts as a probe for the presence of the target in a Southern blot assay or, more commonly, in the simpler Dot blot assay.DNA-binding proteinCpG OligodeoxynucleotideChromosome regionsSticky and blunt ends: DNA end or sticky end refers to the properties of the end of a molecule of DNA or a recombinant DNA molecule. The concept is important in molecular biology, especially in cloning or when subcloning inserts DNA into vector DNA.Margaret Jope: Margaret Jope (1913–2004) was a Scottish biochemist, born as Henrietta Margaret Halliday in Peterhead, Scotland.Transmembrane domain: Transmembrane segment usually denotes a single transmembrane alpha helix of a transmembrane protein, also known as an integral protein.http://www.Transfer-messenger RNA: Transfer-messenger RNA (abbreviated tmRNA, also known as 10Sa RNA and by its genetic name SsrA) is a bacterial RNA molecule with dual tRNA-like and messenger RNA-like properties. The tmRNA forms a ribonucleoprotein complex (tmRNP) together with Small Protein B (SmpB), Elongation Factor Tu (EF-Tu), and ribosomal protein S1.SEA Native Peptide LigationNASBA (molecular biology): Nucleic acid sequence based amplification (NASBA) is a method in molecular biology which is used to amplify RNA sequences.Zuotin: Z-DNA binding protein 1, also known as Zuotin, is a Saccharomyces cerevisiae yeast gene.Ethyl groupPhase problem: In physics the phase problem is the name given to the problem of loss of information concerning the phase that can occur when making a physical measurement. The name itself comes from the field of x-ray crystallography, where the phase problem has to be solved for the determination of a structure from diffraction data.Beef cattle: Beef cattle are cattle raised for meat production (as distinguished from dairy cattle, used for milk production). The meat of adult cattle is known as beef.RNA transfection: RNA transfection is the process of deliberately introducing RNA into a living cell. RNA can be purified from cells after lysis or synthesized from free nucleotides either chemically, or enzymatically using an RNA polymerase to transcribe a DNA template.Membrane protein: Membrane proteins are proteins that interact with biological membranes. They are one of the common types of protein along with soluble globular proteins, fibrous proteins, and disordered proteins.GC box: In molecular biology, a GC box is a distinct pattern of nucleotides found in the promoter region of some eukaryotic genes upstream of the TATA box and approximately 110 bases upstream from the transcription initiation site. It has a consensus sequence GGGCGG which is position dependent and orientation independent.MT-RNR2: Mitochondrially encoded 16S RNA (often abbreviated as 16S) is a mitochondrial ribosomal RNA (rRNA) that in humans is encoded by the MT-RNR2 gene. The MT-RNR2 gene also encodes the Humanin polypeptide that has been the target of Alzheimer's disease research.Ribonuclease T2: Ribonuclease T2 (, ribonuclease II, base-non-specific ribonuclease, nonbase-specific RNase, RNase (non-base specific), non-base specific ribonuclease, nonspecific RNase, RNase Ms, RNase M, RNase II, Escherichia coli ribonuclease II, ribonucleate nucleotido-2'-transferase (cyclizing), acid ribonuclease, RNAase CL, Escherichia coli ribonuclease I' ribonuclease PP2, ribonuclease N2, ribonuclease M, acid RNase, ribonnuclease (non-base specific), ribonuclease (non-base specific), RNase T2, ribonuclease PP3, ribonucleate 3'-oligonucleotide hydrolase, ribonuclease U4) is an enzyme. This enzyme catalyses the following chemical reactionAssay sensitivity: Assay sensitivity is a property of a clinical trial defined as the ability of a trial to distinguish an effective treatment from a less effective or ineffective intervention. Without assay sensitivity, a trial is not internally valid and is not capable of comparing the efficacy of two interventions.Proteinogenic amino acid: Proteinogenic amino acids are amino acids that are precursors to proteins, and are incorporated into proteins cotranslationally — that is, during translation. There are 23 proteinogenic amino acids in prokaryotes (including N-Formylmethionine, mainly used to initiate protein synthesis and often removed afterward), but only 21 are encoded by the nuclear genes of eukaryotes.Translational regulation: Translational regulation refers to the control of the levels of protein synthesized from its mRNA. The corresponding mechanisms are primarily targeted on the control of ribosome recruitment on the initiation codon, but can also involve modulation of the elongation or termination of protein synthesis.Permissive temperature: The permissive temperature is the temperature at which a temperature sensitive mutant gene product takes on a normal, functional phenotype.http://www.NTP binding site: An NTP binding site is a type of binding site found in nucleoside monophosphate (NMP) kinases, N can be adenosine or guanosine. A P-loop is one of the structural motifs common for nucleoside triphosphate (NTP) binding sites, it interacts with the bound nucleotide's phosphoryl groups.Mac OS X Server 1.0

(1/18435) Ultrabithorax function in butterfly wings and the evolution of insect wing patterns.

BACKGROUND: . The morphological and functional evolution of appendages has played a critical role in animal evolution, but the developmental genetic mechanisms underlying appendage diversity are not understood. Given that homologous appendage development is controlled by the same Hox gene in different organisms, and that Hox genes are transcription factors, diversity may evolve from changes in the regulation of Hox target genes. Two impediments to understanding the role of Hox genes in morphological evolution have been the limited number of organisms in which Hox gene function can be studied and the paucity of known Hox-regulated target genes. We have therefore analyzed a butterfly homeotic mutant 'Hindsight', in which portions of the ventral hindwing pattern are transformed to ventral forewing identity, and we have compared the regulation of target genes by the Ultrabithorax (Ubx) gene product in Lepidopteran and Dipteran hindwings. RESULTS: . We show that Ubx gene expression is lost from patches of cells in developing Hindsight hindwings, correlating with changes in wing pigmentation, color pattern elements, and scale morphology. We use this mutant to study how regulation of target genes by Ubx protein differs between species. We find that several Ubx-regulated genes in the Drosophila haltere are not repressed by Ubx in butterfly hindwings, but that Distal-less (Dll) expression is regulated by Ubx in a unique manner in butterflies. CONCLUSIONS: . The morphological diversification of insect hindwings has involved the acquisition of different sets of target genes by Ubx in different lineages. Changes in Hox-regulated target gene sets are, in general, likely to underlie the morphological divergence of homologous structures between animals.  (+info)

(2/18435) Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation.

The telomerase reverse transcriptase component (TERT) is not expressed in most primary somatic human cells and tissues, but is upregulated in the majority of immortalized cell lines and tumors. Here, we identify the c-Myc transcription factor as a direct mediator of telomerase activation in primary human fibroblasts through its ability to specifically induce TERT gene expression. Through the use of a hormone inducible form of c-Myc (c-Myc-ER), we demonstrate that Myc-induced activation of the hTERT promoter requires an evolutionarily conserved E-box and that c-Myc-ER-induced accumulation of hTERT mRNA takes place in the absence of de novo protein synthesis. These findings demonstrate that the TERT gene is a direct transcriptional target of c-Myc. Since telomerase activation frequently correlates with immortalization and telomerase functions to stabilize telomers in cycling cells, we tested whether Myc-induced activation of TERT gene expression represents an important mechanism through which c-Myc acts to immortalize cells. Employing the rat embryo fibroblast cooperation assay, we show that TERT is unable to substitute for c-Myc in the transformation of primary rodent fibroblasts, suggesting that the transforming activities of Myc extend beyond its ability to activate TERT gene expression and hence telomerase activity.  (+info)

(3/18435) Analysis of two cosmid clones from chromosome 4 of Drosophila melanogaster reveals two new genes amid an unusual arrangement of repeated sequences.

Chromosome 4 from Drosophila melanogaster has several unusual features that distinguish it from the other chromosomes. These include a diffuse appearance in salivary gland polytene chromosomes, an absence of recombination, and the variegated expression of P-element transgenes. As part of a larger project to understand these properties, we are assembling a physical map of this chromosome. Here we report the sequence of two cosmids representing approximately 5% of the polytenized region. Both cosmid clones contain numerous repeated DNA sequences, as identified by cross hybridization with labeled genomic DNA, BLAST searches, and dot matrix analysis, which are positioned between and within the transcribed sequences. The repetitive sequences include three copies of the mobile element Hoppel, one copy of the mobile element HB, and 18 DINE repeats. DINE is a novel, short repeated sequence dispersed throughout both cosmid sequences. One cosmid includes the previously described cubitus interruptus (ci) gene and two new genes: that a gene with a predicted amino acid sequence similar to ribosomal protein S3a which is consistent with the Minute(4)101 locus thought to be in the region, and a novel member of the protein family that includes plexin and met-hepatocyte growth factor receptor. The other cosmid contains only the two short 5'-most exons from the zinc-finger-homolog-2 (zfh-2) gene. This is the first extensive sequence analysis of noncoding DNA from chromosome 4. The distribution of the various repeats suggests its organization is similar to the beta-heterochromatic regions near the base of the major chromosome arms. Such a pattern may account for the diffuse banding of the polytene chromosome 4 and the variegation of many P-element transgenes on the chromosome.  (+info)

(4/18435) The mouse Aire gene: comparative genomic sequencing, gene organization, and expression.

Mutations in the human AIRE gene (hAIRE) result in the development of an autoimmune disease named APECED (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy; OMIM 240300). Previously, we have cloned hAIRE and shown that it codes for a putative transcription-associated factor. Here we report the cloning and characterization of Aire, the murine ortholog of hAIRE. Comparative genomic sequencing revealed that the structure of the AIRE gene is highly conserved between human and mouse. The conceptual proteins share 73% homology and feature the same typical functional domains in both species. RT-PCR analysis detected three splice variant isoforms in various mouse tissues, and interestingly one isoform was conserved in human, suggesting potential biological relevance of this product. In situ hybridization on mouse and human histological sections showed that AIRE expression pattern was mainly restricted to a few cells in the thymus, calling for a tissue-specific function of the gene product.  (+info)

(5/18435) ATF-2-binding regulatory element is responsible for the Ly49A expression in murine T lymphoid line, EL-4.

To understand the mechanism of Ly49A-expression and its significance in T-cell differentiation, we analyzed the 5'-flanking region of the Ly49A gene in a search for the Ly49A-regulatory element. Since very few known regulatory elements have been found in this region, presumably a novel regulatory sequence(s) could exist. Accordingly, we defined the 13-bp regulatory element, 5'-ATGACGAGGAGGA-3', restricted to Ly49A-expression in EL-4 cells in comparison with two other representative cell lines tested. This element, designated as EL13, proved to be previously undiscovered by homology search and is highly homologous with several virus DNAs. Using EL13 as a probe we have cloned a cDNA encoding a binding protein to EL13. Its deduced nucleotide sequence revealed that EL13-binding protein is almost identical with rat ATF-2. Although ATF-2 is known to bind to cyclic AMP responsive element (CRE), EL13 shares five out of eight nucleotides with this consensus sequence. Our results suggested that ATF-2 may play an important role via binding to EL13 for the expression of Ly49A. These data will provide useful information for understanding T-cell and NK-cell differentiation in murine immune system.  (+info)

(6/18435) Cloning and functional characterization of the 5'-flanking region of the human bone morphogenetic protein-2 gene.

Bone morphogenetic protein-2 (BMP-2) is involved in bone formation, organogenesis or pattern formation during development. The expression of BMP-2 is regulated accurately and coordinately with that of other transforming growth factor-beta (TGF-beta) superfamily members. To elucidate the mechanism underlying the regulation of BMP-2 expression, a 6.7 kb SpeI-SalI fragment, from the P1 phage library, encompassing the 5'-flanking region of the human BMP-2 gene, was isolated and sequenced. Transcription start sites were mapped by the 5'-rapid amplification of cDNA ends (RACE) method. It has been found that the human BMP-2 gene contains, largely, two promoter regions surrounded by GC-rich sequences with several Sp1 consensus motifs. The proximal promoter possesses a single start site, whereas several start sites are clustered in the distal promoter region. Neither TATA nor CAAT consensus sequences are found in the proximity of the start sites for either promoter. Interestingly, in no case is the transcription-initiation site common between the human and mouse BMP-2 genes, although the sequence of the BMP-2 gene is well conserved in the promoter region between two species. Transient transfection experiments with the reporter fused with various lengths of the BMP-2 promoter sequence demonstrated that there exist enhancer elements in an 1.1 kb GC-rich fragment covering both promoter regions. It is noteworthy that the enhancer elements are 5'-flanked by a 790 bp strong repressor element that is characterized by numerous AT stretches. This intriguing organization may be amenable to the tight control of the expression of BMP-2 that is essential for development or bone morphogenesis.  (+info)

(7/18435) Use of RhD fusion protein expressed on K562 cell surface in the study of molecular basis for D antigenic epitopes.

The human D antigens, one of the most clinically important blood groups, are presented by RhD protein with a putative 12 transmembrane topology. To understand the molecular basis for the complex antigenic profile of RhD protein, we expressed a series of RhD fusion proteins using different portions of Duffy protein as a tag in erythroleukemic K562 cells. Because the reactivity of monoclonal anti-RhD antibody, LOR15C9, depends mainly on the sequence coded by exon 7 of RhD, we altered DNA sequence corresponding to the amino acid residues 323-331(A) and 350-354(B) in the exon 7. The mutation in region B resulted in a severe reduction in LOR15C9 binding by flow cytometry analysis, suggesting that region B may play an important role in constituting antigen epitopes recognized by LOR15C9. On the other hand, a slight decrease in the antibody binding was observed for the region A mutant, suggesting that the intracellularly located region A may elicit a long distance effect on the formation of exofacial antigen epitopes. In addition, using various monoclonal antibodies against RhD, we compared the antigenic profile of expressed RhD fusion protein with that of endogenous RhD in K562 cells as well as in erythrocytes.  (+info)

(8/18435) Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells.

Accumulation of mesangial matrix is a pivotal event in the pathophysiology of diabetic nephropathy. The molecular triggers for matrix production are still being defined. Here, suppression subtractive hybridization identified 15 genes differentially induced when primary human mesangial cells are exposed to high glucose (30 mM versus 5 mM) in vitro. These genes included (a) known regulators of mesangial cell activation in diabetic nephropathy (fibronectin, caldesmon, thrombospondin, and plasminogen activator inhibitor-1), (b) novel genes, and (c) known genes whose induction by high glucose has not been reported. Prominent among the latter were genes encoding cytoskeleton-associated proteins and connective tissue growth factor (CTGF), a modulator of fibroblast matrix production. In parallel experiments, elevated CTGF mRNA levels were demonstrated in glomeruli of rats with streptozotocin-induced diabetic nephropathy. Mannitol provoked less mesangial cell CTGF expression in vitro than high glucose, excluding hyperosmolality as the key stimulus. The addition of recombinant CTGF to cultured mesangial cells enhanced expression of extracellular matrix proteins. High glucose stimulated expression of transforming growth factor beta1 (TGF-beta1), and addition of TGF-beta1 to mesangial cells triggered CTGF expression. CTGF expression induced by high glucose was partially suppressed by anti-TGF-beta1 antibody and by the protein kinase C inhibitor GF 109203X. Together, these data suggest that 1) high glucose stimulates mesangial CTGF expression by TGFbeta1-dependent and protein kinase C dependent pathways, and 2) CTGF may be a mediator of TGFbeta1-driven matrix production within a diabetic milieu.  (+info)


The lac regulatory system is important to bacteria because the sugar lactose?


(continue)
The lac regulatory system is important to bacteria because the sugar lactose

a. cannot be made by bacteria unless the genes are turned on. 
b. is the most common source of food; enzymes are needed all the time. 
c. is only rarely available; producing enzymes all the time is costly. 
d. is incorporated into the nucleic acid of the bacteria. 
e. switches the system off and on whether lactose is present or not.
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b. is the most common source of food; enzymes are needed all the time.


What is low-acid coffee, how do they make it, and what are the best brands?


I've heard of low-acid coffee and I think it might help with my stomach problems. I'm wondering what it is exactly, how they make it, and which brands are considered to be the best. Thanks!
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When coffee beans are roasted, acid is extraced due to the heat inside the roasters themselves. One of the most popular ways to take the acid down, is to put the beans through a steaming process that eliminates most of the acid or by roasting the beans to be as dark as humanly possible without buring them (darker roasts tend to have less acid, believe it or not). Recently, there was a company that said it had the lowest acididity rate on the market called Puroast. I haven't hear any of their cupping reviews, however. 

Finding a good, low-acid coffee might be harder to find on the normal market, I fear. Roasters are just now starting to look at the growing numbers of people who need this kind of brew. From everything I have read, Brazilian and Sumatrian beans look like they are going to be able to deliver low-acid with great taste. You do have to realise, however, that this is still a work in progress for the coffee industry. You are going to need to give us some time. I do, however have a process you can do at home to lower the acidity in your coffee. The downside is that it is for iced coffee, and I only know how to make it in kind of a large dose (but it keeps for quite a while). Let me know if you want it!


How do I prepare Salicylic Acid in powder form to use as an acne cure?


I have purchased Salicylic Acid, but unfortunately has come with health warning and no instructions for how to use or what mix is necessary.  Please does anyone know what the spell/recipe is for acne?
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Salicylic acid is essentially aspirin. I have taken an aspirin, crushed it into the powder, added a little water to make a not too thick or not too thin paste, then put it on a blemish, top it with a "spot" bandage and let it work over night. It works fine and I have had no reactions, however some people with sensitive skin may react...it is on the acidic side of the pH scale, although not as strong as hydrochloric acid, I imagine it could cause some irritation. If you get irritation, try it during the day for only a few hours. Good luck!


How long does it take for acid reflux in babies to go away?


My 2 month old baby has acid reflux. He is on Prevacid and Mylanta. I burp him and hold him upright for 30 mins after each meal. Question for all parents whose babies have had acid reflux: How long did it take for your babies to get rid off their acid reflux ?
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My son has acid reflux.... He also has tracheomalacia (weakened trachea) He was on hypoallergenic formula... I didnt put him on zantac or prevacid or anything like that... the dr did suggest putting some cereal in the bottles, but I didnt want to do that either..

He is 6 months old now and is pretty much done with the whole acid reflux thing... He spits up sometimes, but not like he used to. We switched him back over to milk based formula when he started solids (around 5 months) and he has been good ever since.

I think it is really a baby by baby thing... each baby just has to grow out of it on their own.

Good luck.


What can sulfuric acid do to your skin after prolonged exposure?


I have a friend who spilled sulfuric acid on his arm at work and he won't go to the hospital. He now has a hole in his arm.
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Sulfuric acid is a strong Acid if undiluted (0 on ph scale) and would not just, "leave a pale spot" because it is extremely corrosive. I've learned from a man who worked in some plants It eats through the tissue until it loses surface tension of your appendage and falls to further eat through most floors until in safe containment, IE Metals that cannot be corroded away.


How does adding an acid to vegetable cooking water affect the vegetable?


I want to know what will happen when you add acid to different types of vegetables -- green, red, orange, white. Also, how can you artificially enhance or diminish the acid-pigment interaction in an aqueous (that's water) environment. Explain the science involved in detail.
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the only thing i can think of is an acid would help keep certain vegetables from oxidizing or changing color like eggplant. it also acts as a preservative for many vegetables depending on how much acid you use or mix with water u can go as far as pickling a vegetable.
it also keeps a veggey like fresh artichokes from turning brown in a solution of water and a little acid


How much folic acid to take before getting pregnant?


I just heard that you should take folic acid before getting pregnant,  but how much,  I see some bottles that say 800mcg,  and some say more.

Is it possible to get too much?
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skip folic acid and start taking prenatal vitamins now they have plenty.


How do I get rid of lactic acid build up in my legs?


I know I have lactic acid build up in my legs because they hurt and I cant move and can't walk. I was wondering how I could get rid of the lactic acid?
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Stretching your legs will make the acid move around, and your legs will stop hurting.

Make sure to stretch before and after a workout.