Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.ROC Curve: A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Kinetics: The rate dynamics in chemical or physical systems.Contrast Sensitivity: The ability to detect sharp boundaries (stimuli) and to detect slight changes in luminance at regions without distinct contours. Psychophysical measurements of this visual function are used to evaluate visual acuity and to detect eye disease.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Reagent Kits, Diagnostic: Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.False Positive Reactions: Positive test results in subjects who do not possess the attribute for which the test is conducted. The labeling of healthy persons as diseased when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Sequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.Protein Structure, Tertiary: The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.Immunoassay: A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.Evaluation Studies as Topic: Studies determining the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. For drugs and devices, CLINICAL TRIALS AS TOPIC; DRUG EVALUATION; and DRUG EVALUATION, PRECLINICAL are available.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.False Negative Reactions: Negative test results in subjects who possess the attribute for which the test is conducted. The labeling of diseased persons as healthy when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)DNA Primers: Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.Organ Specificity: Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Mutagenesis, Site-Directed: Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Bacterial Proteins: Proteins found in any species of bacterium.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Multiple Chemical Sensitivity: An acquired disorder characterized by recurrent symptoms, referable to multiple organ systems, occurring in response to demonstrable exposure to many chemically unrelated compounds at doses below those established in the general population to cause harmful effects. (Cullen MR. The worker with multiple chemical sensitivities: an overview. Occup Med 1987;2(4):655-61)Sensory Thresholds: The minimum amount of stimulus energy necessary to elicit a sensory response.Recombinant Fusion Proteins: Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.Epitopes: Sites on an antigen that interact with specific antibodies.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Bacteriological Techniques: Techniques used in studying bacteria.Protein Conformation: The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).Cross Reactions: Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.Insulin: A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Serologic Tests: Diagnostic procedures involving immunoglobulin reactions.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Temperature: The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Molecular Diagnostic Techniques: MOLECULAR BIOLOGY techniques used in the diagnosis of disease.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Cell Line, Tumor: A cell line derived from cultured tumor cells.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Immunoenzyme Techniques: Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.Host Specificity: The properties of a pathogen that makes it capable of infecting one or more specific hosts. The pathogen can include PARASITES as well as VIRUSES; BACTERIA; FUNGI; or PLANTS.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.DNA, Bacterial: Deoxyribonucleic acid that makes up the genetic material of bacteria.Crystallography, X-Ray: The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Amino Acid Substitution: The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.Mass Screening: Organized periodic procedures performed on large groups of people for the purpose of detecting disease.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Binding, Competitive: The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.Hydrolysis: The process of cleaving a chemical compound by the addition of a molecule of water.Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Saccharomyces cerevisiae: A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Plasmids: Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.Drug Resistance: Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.Ligands: A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)Phosphorylation: The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.Catalytic Domain: The region of an enzyme that interacts with its substrate to cause the enzymatic reaction.Mice, Inbred C57BLPeptide Fragments: Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Antigens, Bacterial: Substances elaborated by bacteria that have antigenic activity.Observer Variation: The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).Reference Values: The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Molecular Weight: The sum of the weight of all the atoms in a molecule.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Catalysis: The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Clinical Laboratory Techniques: Techniques used to carry out clinical investigative procedures in the diagnosis and therapy of disease.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Drug Resistance, Neoplasm: Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.Virology: The study of the structure, growth, function, genetics, and reproduction of viruses, and VIRUS DISEASES.Mutagenesis: Process of generating a genetic MUTATION. It may occur spontaneously or be induced by MUTAGENS.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Blood Glucose: Glucose in blood.Glucose Tolerance Test: A test to determine the ability of an individual to maintain HOMEOSTASIS of BLOOD GLUCOSE. It includes measuring blood glucose levels in a fasting state, and at prescribed intervals before and after oral glucose intake (75 or 100 g) or intravenous infusion (0.5 g/kg).Isoenzymes: Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Immunoglobulin M: A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Reference Standards: A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Cell Membrane: The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.Cell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.Amino Acids: Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.Protein Structure, Secondary: The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.Light: That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range.Parasitology: The study of parasites and PARASITIC DISEASES.Cricetinae: A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.Fluorescent Antibody Technique: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.Protein Engineering: Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.Feces: Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Glucose: A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.Hot Temperature: Presence of warmth or heat or a temperature notably higher than an accustomed norm.Glucose Clamp Technique: Maintenance of a constant blood glucose level by perfusion or infusion with glucose or insulin. It is used for the study of metabolic rates (e.g., in glucose, lipid, amino acid metabolism) at constant glucose concentration.Area Under Curve: A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)Mycobacterium tuberculosis: A species of gram-positive, aerobic bacteria that produces TUBERCULOSIS in humans, other primates, CATTLE; DOGS; and some other animals which have contact with humans. Growth tends to be in serpentine, cordlike masses in which the bacilli show a parallel orientation.Radiopharmaceuticals: Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)Nucleic Acid Amplification Techniques: Laboratory techniques that involve the in-vitro synthesis of many copies of DNA or RNA from one original template.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Specimen Handling: Procedures for collecting, preserving, and transporting of specimens sufficiently stable to provide accurate and precise results suitable for clinical interpretation.DNA, Complementary: Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.Carbohydrate Sequence: The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.Computer Simulation: Computer-based representation of physical systems and phenomena such as chemical processes.Culture Media: Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Biosensing Techniques: Any of a variety of procedures which use biomolecular probes to measure the presence or concentration of biological molecules, biological structures, microorganisms, etc., by translating a biochemical interaction at the probe surface into a quantifiable physical signal.Oligopeptides: Peptides composed of between two and twelve amino acids.Peptide Library: A collection of cloned peptides, or chemically synthesized peptides, frequently consisting of all possible combinations of amino acids making up an n-amino acid peptide.Photic Stimulation: Investigative technique commonly used during ELECTROENCEPHALOGRAPHY in which a series of bright light flashes or visual patterns are used to elicit brain activity.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Breast Neoplasms: Tumors or cancer of the human BREAST.Enzyme Inhibitors: Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.Mice, Inbred BALB CDiagnostic Errors: Incorrect diagnoses after clinical examination or technical diagnostic procedures.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Diagnostic Tests, Routine: Diagnostic procedures, such as laboratory tests and x-rays, routinely performed on all individuals or specified categories of individuals in a specified situation, e.g., patients being admitted to the hospital. These include routine tests administered to neonates.Autoantibodies: Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.Immunologic Tests: Immunologic techniques involved in diagnosis.Immunoblotting: Immunologic method used for detecting or quantifying immunoreactive substances. The substance is identified by first immobilizing it by blotting onto a membrane and then tagging it with labeled antibodies.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Amino Acid Motifs: Commonly observed structural components of proteins formed by simple combinations of adjacent secondary structures. A commonly observed structure may be composed of a CONSERVED SEQUENCE which can be represented by a CONSENSUS SEQUENCE.Reagent Strips: Narrow pieces of material impregnated or covered with a substance used to produce a chemical reaction. The strips are used in detecting, measuring, producing, etc., other substances. (From Dorland, 28th ed)Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Saccharomyces cerevisiae Proteins: Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.Radioimmunoassay: Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.Swine: Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).DNA Probes: Species- or subspecies-specific DNA (including COMPLEMENTARY DNA; conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32P and 125I and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.Ultraviolet Rays: That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.HeLa Cells: The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.Fluorescent Dyes: Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.Contrast Media: Substances used to allow enhanced visualization of tissues.Baroreflex: A response by the BARORECEPTORS to increased BLOOD PRESSURE. Increased pressure stretches BLOOD VESSELS which activates the baroreceptors in the vessel walls. The net response of the CENTRAL NERVOUS SYSTEM is a reduction of central sympathetic outflow. This reduces blood pressure both by decreasing peripheral VASCULAR RESISTANCE and by lowering CARDIAC OUTPUT. Because the baroreceptors are tonically active, the baroreflex can compensate rapidly for both increases and decreases in blood pressure.Escherichia coli Proteins: Proteins obtained from ESCHERICHIA COLI.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Point Mutation: A mutation caused by the substitution of one nucleotide for another. This results in the DNA molecule having a change in a single base pair.Immune Sera: Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.Microscopy: The use of instrumentation and techniques for visualizing material and details that cannot be seen by the unaided eye. It is usually done by enlarging images, transmitted by light or electron beams, with optical or magnetic lenses that magnify the entire image field. With scanning microscopy, images are generated by collecting output from the specimen in a point-by-point fashion, on a magnified scale, as it is scanned by a narrow beam of light or electrons, a laser, a conductive probe, or a topographical probe.Adenosine Triphosphate: An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.Biological Transport: The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.Visual Fields: The total area or space visible in a person's peripheral vision with the eye looking straightforward.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Image Processing, Computer-Assisted: A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Enzyme Activation: Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.Visual Field Tests: Method of measuring and mapping the scope of vision, from central to peripheral of each eye.Hemagglutination Tests: Sensitive tests to measure certain antigens, antibodies, or viruses, using their ability to agglutinate certain erythrocytes. (From Stedman, 26th ed)Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Positron-Emission Tomography: An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.Staining and Labeling: The marking of biological material with a dye or other reagent for the purpose of identifying and quantitating components of tissues, cells or their extracts.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Point-of-Care Systems: Laboratory and other services provided to patients at the bedside. These include diagnostic and laboratory testing using automated information entry.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Adaptation, Ocular: The adjustment of the eye to variations in the intensity of light. Light adaptation is the adjustment of the eye when the light threshold is increased; DARK ADAPTATION when the light is greatly reduced. (From Cline et al., Dictionary of Visual Science, 4th ed)Latex Fixation Tests: Passive agglutination tests in which antigen is adsorbed onto latex particles which then clump in the presence of antibody specific for the adsorbed antigen. (From Stedman, 26th ed)Agglutination Tests: Tests that are dependent on the clumping of cells, microorganisms, or particles when mixed with specific antiserum. (From Stedman, 26th ed)Conserved Sequence: A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. AMINO ACID MOTIFS are often composed of conserved sequences.

*  A sensitive and specific high performance liquid chromatographic assay for milrinone in rat and hum
A sensitive and specific high performance liquid ... milrinone in rat and human plasma using a commercially ... internal standard and low sample volume. A sensitive and specific high performance liquid...
https://sites.ualberta.ca/~csps/JPPS8(2)/D.Brocks/milrinone.htm
*  BioSpace - Print News Article
tests have poor sensitivity and specificity during the early stages ... may go untreated and thus progress to late stage lyme ... they face longer and more invasive treatments as well as...
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*  I am coming to San Pedro for 2-3 months, maybe longer. Can I receive General Delivery mail in San Pe
ahead of time and do t. Search. Belize Ambergris Caye ... ahead of time and do t. Last Updated: Sun, Dec 3, 2006 1: ... experience renting and shipping a 20 or 40 container of...
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*  www.arthritis-research.com - Table
Table. Table 4. Sensitivity and specificity of Anti-Scl-70 in ... :. Assay used. Sensitivity %. Specificity %. Normal controls. ... Ho and Reveille Arthritis Res Ther 2003 5 :80- ... www arthritis research com table table sensitivity and specificity of anti scl in diagnosis of ssc ssc versus assay used sensitivity specificity normal controls id ib elisa overall other connective tissue diseases id ib elisa overall primary raynaud s phenomenon id non ssc relatives id reference reference elisa enzyme linked immunosorbent assay ib immunoblotting id immunodiffusion ho and reveille arthritis res ther doi ar...
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*  A systematic review of prognostic tools for estimating survival time in palliative care
care methods standards predictive value of tests ... risk assessment sensitivity and specificity severity of illness ... centre for reviews and dissemination copyright university...
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*  Pemphigoid - ARUP Consult, Your Online Lab Test Resource
Test Selection and Interpretation Pemphigoid Dx. Monitor ... stomatitis and conjunctivitis Laboratory Testing ... , pemphigus panels and endomysial antibodies all three test ... Preferred antibody panel for initial diagnostic assessment and disease monitoring in pemphigoid, epidermolysis bullosa acquisita, and linear IgA bullous dermatosis Panel components include IgG and IgA epithelial BMZ antibodies and IgG bullous pemphigoid BP 180 230 antigens To order individual component tests, refer to antibody testing for IgG BMZ, IgA BMZ, and/or IgG bullous pemphigoid BP 180 230 antigens To screen for pemphigoid along with other possible immunobullous diseases, order concurrently with the pemphigus antibody panel IgG collagen type VII antibody, AND perilesional skin biopsy for direct immunofluorescence Concurrent perilesional skin biopsy for DIF is important for diagnosis because of increased sensitivity 85-100% of pemphigus, pemphigoid, linear IgA disease, epidermolysis bullosa acquisita, and dermatitis herpetif...
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*  www.biomedcentral.com - Table
of high, moderate and low study quality, mainly according to ... a representative and clinically relevant sample QUADAS items ... of the reference standard item 7. ● evaluators should be ... www biomedcentral com table table criteria of high moderate and low study quality mainly according to quadas high small risk of bias prospective study design particular emphasis on the following adequately described patients constituting a representative and clinically relevant sample quadas items the index test should not form part of the reference standard item evaluators should be masked to results of index test and reference test items the tests should be described in sufficient detail to permit replication items sample size diagnostic accuracy presented as sensitivity and specificity moderate moderate risk of bias prospective study design since no prospective studies based on digital mammography could be identified scanned analogue images were accepted otherwise the same criteria as for high quality were require...
http://biomedcentral.com/1471-2342/12/22/table/T1
*  Review of Ophthalmology® > Review of Ophthalmology Online > January 28, 2013 - Vol. 13, Num. 5
Aqueous VEGF and Endothelin-1 Levels in BRVO Associated ... Changes in VF Sensitivity and IOP. Clinical Characteristics in ... to detect and classify severity of age-related ... Automated AMD Severity Classification Using Fundus Photographs. Link Between Aqueous VEGF and Endothelin-1 Levels in BRVO Associated with NTG. Western NTG Patients. Automated AMD Severity Classification Using Fundus Photographs The authors of this study evaluated an automated analysis of retinal fundus photographs to detect and classify severity of age-related macular degeneration AMD compared with grading by the Age-Related Eye Disease Study AREDS protocol. Link Between Aqueous VEGF and Endothelin-1 Levels in BRVO Associated with NTG To evaluate aqueous levels of vascular endothelial growth factor VEGF and endothelin-1 ET-1 in patients with branch retinal vein occlusion BRVO with and without normal tension glaucoma NTG, and to assess the therapeutic efficacy of intravitreal bevacizumab IVB in these patients, researchers followe...
http://reviewofophthalmology.com/e-newsletters/rponlinenl/c/38923/
*  Rapid diagnosis of respiratory syncytial virus infection by using Pernasal swabs - Enlighten: Publ
, P.J., Getty, S., and Paton, J. 1991 Rapid diagnosis of ... 2653. Abstract. The sensitivity and specificity of direct ... swab specimens and compared with those of nasopharyngeal...
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*  BioSpace - Detection of Human Papillomaviruses by Polymerase Chain Reaction and Ligation Reaction
Chain Reaction and Ligation Reaction on Universal ... Chain Reaction and Ligation Reaction on Universal ... , Eeva Auvinen Sensitive and specific detection of human ... BioSpace - Detection of Human Papillomaviruses by Polymerase Chain Reaction and Ligation Reaction on Universal Microarray. Login. Post Jobs. Job Seeker:. Login. Jobs. Career Resources. Career Fairs. Company Profiles. Search Life Sciences Jobs. Search Job Title Only. Recent PLoS Articles. Detection of Human Papillomaviruses by Polymerase Chain Reaction and Ligation Reaction on Universal Microarray Published: Friday, March 23, 2012 Author: Jarmo Ritari et al. by Jarmo Ritari, Jenni Hultman, Rita Fingerroos, Jussi Tarkkanen, Janne Pullat, Lars Paulin, Niina Kivi, Petri Auvinen, Eeva Auvinen Sensitive and specific detection of human papillomaviruses HPV in cervical samples is a useful tool for the early diagnosis of epithelial neoplasia and anogenital lesions. Recent studies support the feasibility of HPV DNA testing instead of cytology Pap sm...
http://biospace.com/PLos_Article.aspx?id=11621
*  A simple and highly sensitive method for sequence determination of 32P-labeled oligonucleotides
... Add publications. Advanced Home. Publications. A simple and highly sensitive method for sequence determination of 32P-labeled oligonucleotides. Guido Volckaert. and Walter Fiers UGent. ANALYTICAL BIOCHEMISTRY. Google Scholar find title. SFX find at UGent. Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-1927146. Cite this. Guido Volckaert. and Walter Fiers UGent. Department of Biochemistry. alternative title Simple and highly sensitive method for sequence determination of P-32-labeled oligonucleotides year 1974 type journalArticle original publication status published subject. journal title. ANALYTICAL BIOCHEMISTRY Anal. volume 62 issue 2 pages 573 - 583 Web of Science type Article ISSN. 0003-2697 DOI. A1 id 1927146 handle. http://hdl.handle.net/1854/LU-1927146 date created 2011-10-13 11:16:04 date last changed 2013-01-30 09:44:26. @article{1927146, author = {Volckaert, Guido and Fiers, Walter}, issn = {0003-2697}, journal = {ANALYTICAL BIOCHEMISTRY}, language = {eng...
https://biblio.ugent.be/publication/1927146
*  ALLDATAdiy.com - 2009 Nissan-Datsun Altima V6-3.5L (VQ35DE) - Pinout Values and Diagnostic Parameter
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*  Tuberculosis Test Unreliable
... View mobile site. HuffPost's QuickRead... Loading... Afghanistan. iOS app Android app. Desktop Alerts. Log in Create Account. Profile. Settings. Logout. October 4, 2015. Edition: U.S. AR عربي Arabic. AU Australia. BR Brasil. CA Canada. DE Deutschland. ES Espa a. FR France. GR Ελλάδα Greece. IN India. IT Italia. JP 日本 Japan. KR 한국 Korea. MG Maghreb. UK United Kingdom. US United States. . Follow. FRONT PAGE. Politics. Wednesday's Morning Email: Jeb Goes After Trump. Go to Politics. More in Politics. Pollster. Politics Blog. Off The Bus. Election Maps. Trail To The Chief. You might also like. WorldPost. Green. Black Voices. Latino Voices. Gay Voices. Business. These Often-Overlooked Tips Will Revolutionize Your Online Job Hunting. Go to Business. More in Business. Small Biz. Money. You might also like. WorldPost. Tech. Media. Arts. Sports. Weird News. Smarter Ideas. Urban Progress. Entertainment. The Mad-Genius Effect: How 9 Legendary Minds Rate On The Sanity Scale. Go to Enterta...
http://huffingtonpost.com/news/tuberculosis-test-unreliable/
*  DESERT ROSE BAND - ONE STEP FORWARD LYRICS
... Print. Desert Rose Band — One Step Forward lyrics. Send "One Step Forward" Ringtone to Cell Phone. You held me up held me down made me crazy then you brought me around Were my darkness and my light you were my blindness and my sight Were my shelter and my storm made my cold then you made me warm You were my fever and my cure made me doubt and you made me sure One step forward and two step back nobody gets too far like that One step forward and two steps back this kind of dance can never last. You were my hope and my fear you were my laughter and my tear Were my destiny and my faith kept me moving and you made me wait Were my weakness and my power you were the thorn in the flower You were my sunshine and the rain made me feel so good brough so much pain Now one step forward... And we never really meant for each other we were never really meant to last In the years that we danced together each step forward we took two steps back Each step forward we took two steps back Now one step forward... One step forw...
http://lyricsty.com/desert-rose-band-one-step-forward-lyrics.html
*  GNIRS Sensitivity Estimates | Gemini Observatory
GNIRS Sensitivity Estimates. Gemini Observatory. Gemini Observatory: Exploring The Universe, Sharing its Wonders Science. Public/Images. About. Careers. Contact. Navigation. Announcements enewscast Library PIO Sciops Gemini Home Telescopes and Sites Science Visitors at Gemini Observing With Gemini Instruments Retired Instruments NORTH ALTAIR GMOS GNIRS Status and Availability Spectroscopy Imaging ITC, Sensitivity and Overheads GNIRS ITC Sensitivity Table Overheads Saturation and the ITC. Guiding Options Calibration Observation Preparation Data Format and Reduction System Verification Documents NIR Resources. NIFS NIRI GRACES SOUTH FLAMINGOS-2 GeMS GMOS GPI GSAOI VISITING Interface Specs for VI Visiting Instrument Policy DSSI Speckle Camera TEXES North RESOURCES Integration Time Calculators Magnitudes and Fluxes Near-IR Resources Mid-IR Resources Observing Condition Constraints Performance Monitoring SV/Demo Science. Future Instrumentation Current Development Queue and Schedules Data and Results Helpdesk Stati...
http://gemini.edu/sciops/?q=sciops&q=node/10545
*  Ultra-sensitive biosensor could detect diseases in their earliest stages
... . Advertisement. Search. more top stories. Microsoft re-ignites the PC wars with Windows 10 Surface Book and Surface Pro 4 Star Wars spaceship soars above other sci-fi film treasures to yield record $450,000 at auction Quantum computing breakthrough: Qubits made from standard silicon transistors iPhone 6s and 6s Plus review: 3D Touch is more than a gimmick, but is it reason to upgrade. Health and Wellbeing Ultra-sensitive biosensor could detect diseases in their earliest stages Darren Quick. May 27, 2012. The new ultra-sensitive biosensor has been demonstrated by detecting very small concentrations of Prostate Specific Antigen pictured Image: EAS via Wikipedia. A new ultra-sensitive test developed by scientists from the Imperial College London and Spain’s University of Vigo has the potential to detect the earliest stages of a disease, thereby giving any treatment the best possible chance of succeeding. The researchers claim their new biosensor test is capable of detecting biomarkers molecules which indic...
http://gizmag.com/ultra-sensitive-biosensor/22703/
*  Commentary: effects of diagnostic thresholds and research vs service and administrative diagnosis o
... n autism prevalence - CentAUR. . University of Reading CentAUR: Central Archive at the University of Reading. Accessibility navigation Commentary: effects of diagnostic thresholds and research vs service and administrative diagnosis on autism prevalence. Tools Tools Tools. Wordle Link RDF+XML BibTeX RIOXX2 XML RDF+N-Triples JSON Dublin Core Atom Simple Metadata Refer METS HTML Citation with IDs HTML Citation ASCII Citation OpenURL ContextObject EndNote OpenURL ContextObject in Span MODS MPEG-21 DIDL EP3 XML Dublin Core Reference Manager RDF+N3. Charman, T., Pickles, A., Chandler, S., Wing, L., Bryson, S., Simonoff, E., Loucas, T. and Baird, G. 2009 Commentary: effects of diagnostic thresholds and research vs service and administrative diagnosis on autism prevalence. International Journal of Epidemiology, 38 5. pp. 1234-1238. ISSN 0300-5771 Full text not archived in this repository. To link to this article DOI: 10.1093/ije/dyp256. Item Type: Article. Refereed: Yes. Divisions: Interdisciplinary centres and ...
http://centaur.reading.ac.uk/14123/
*  Leukemia other diagnostic studies - wikidoc
... Leukemia other diagnostic studies. Jump to: navigation , search. Leukemia Microchapters. Overview. Historical Perspective. Classification. AML CML ALL CLL HCL. Differentiating Leukemia from other Diseases. Risk Factors. Natural History, Complications and Prognosis. Diagnosis. Staging. History and Symptoms. Physical Examination. Laboratory Findings. Chest X Ray. MRI. Echocardiography or Ultrasound. Other Imaging Findings. Other Diagnostic Studies. Medical Therapy. Primary Prevention. Cost-Effectiveness of Therapy. Case Studies. Case #1. Leukemia other diagnostic studies On the Web. Most recent articles. Most cited articles. Review articles. Images. American Roentgen Ray Society Images of Leukemia other diagnostic studies. All Images X-rays Echo Ultrasound CT Images MRI. Ongoing Trials at Clinical Trials.gov. FDA on Leukemia other diagnostic studies. CDC on Leukemia other diagnostic studies. Leukemia other diagnostic studies in the news. Blogs on Leukemia other diagnostic studies /small. Directions to Hosp...
http://wikidoc.org/index.php/Leukemia_other_diagnostic_studies
*  .. Category Archives: Universal Detection Technology UNDT .. Universal Detection Technology (
Category Archives: Universal Detection Technology UNDT. Universal Detection Technology UNDT to Present Radiation Detection Technologies in RISCON Safety and Security Expo in Tokyo October 18, 2011. Universal Detection Technology, a company that engages in the research, development, and marketing of bioterrorism detection devices in the United States, announced that the Company’s management will be showcasing its radiation detection technologies in Tokyo, Japan. UNDT is showcasing its equipment at the RISCON Safety and Security Expo. A recent reported has shown that radiation “hot spots” in Tokyo have levels of radioactive Cesium in some areas equivalent to the levels of contaminated areas around Chernobyl in Ukraine, the site of a disastrous nuclear accident in 1986. The results form these tests have led to a growing group of scientists and local residents demanding increased soil testing and immediate efforts for clean up. “Radioactive substances are entering people’s bodies from the air and from the f...
http://blog.qualitystocks.net/category/universal-detection-technology-udttob/
*  Laboratory Equipment - Physiology Instruments
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*  Title page for ETD etd-1204102-123159
... Author Aghassi, Arash. Author's Email Address aaghas1@lsu.edu. Title Investigation of Qualitative Methods for Diagnosis of Poor Bit Performance Using Surface Drilling Parameters. Degree Master of Science in Petroleum Engineering M.S.P.E. Department Petroleum Engineering. Advisory Committee Advisor Name Title. Committee Member. Committee Member. Keywords drilling optimization bit performance rop. This study is part of a larger research project to improve that performance entitled "Automated Rig Controls for Improved Drilling Costs." The objective of the project is diagnosis of changes in drill bit performance to provide a logical basis for automating draw works control, maximizing bit performance, and reducing drilling costs. The specific goal of this study is a means to diagnose bit performance, specifically to identify bit balling and lithology changes, using real-time drilling data. The research began by identifying symptoms relating to specific causes of bit performance changes based on previously pub...
http://etd.lsu.edu/docs/available/etd-1204102-123159/
*  Details - The Structure and Diagnostic Significance of Crateriform Bordered Pits in the Vessels o
... f Cercidium - Biodiversity Heritage Library. Article: The Structure and Diagnostic Significance of Crateriform Bordered Pits in the Vessels of Cercidium. MODS. Title http://www.biodiversitylibrary.org/part/27152 The Structure and Diagnostic Significance of Crateriform Bordered Pits in the Vessels of Cercidium. Original Publication Journal of the Arnold Arboretum. Title The Structure and Diagnostic Significance of Crateriform Bordered Pits in the Vessels of Cercidium. Download MODS mods xmlns:xlink= http://www.w3.org/1999/xlink version= 3.0 xmlns:xsi= http://www.w3.org/2001/XMLSchema-instance xmlns= http://www.loc.gov/mods/v3 xsi:schemaLocation= http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-0.xsd titleInfo title The Structure and Diagnostic Significance of Crateriform Bordered Pits in the Vessels of Cercidium /title /titleInfo name namePart Cozzo, D /namePart /name typeOfResource text /typeOfResource genre authority= marcgt /genre note type= content 34 /note relatedItem type= host ...
http://biodiversitylibrary.org/part/27152
*  SATRO-ECG
... Reference tests Usage Bibliography References External links. Reference tests. The reference tests of the SATRO-ECG method in relation to perfusive scintigraphy SPECT conducted in Military Medical Institute in Warsaw and Medical University of Wroclaw proved the possibility to use this method to detect coronary heart disease CHD. A very high Sensitivity and specificity in detecting this disease were obtained. Sensitivity Se, specificity Sp, predictive value of positive values results PV + and negative values results PV - are presented in the grid below:. Reference tests Se Sp PV + PV -. 'SATRO-ECG – SPECT rest '. 'SATRO-ECG – SPECT exercise '. Comparison of SATRO-ECG results - SPECT exercise for particular parts of the cardiac muscle is presented in the grid below:. 'PV + '. 'PV - '. The results of the tests prove a high correlation the between SATRO-ECG results and SPECT in the case of detection of coronary heart disease CHD. An advantage of this method is a fast and precise analysis of the ECG results i...
https://en.wikipedia.org/wiki/SATRO-ECG
*  Diagnostic test
The pre-test probability of a disease The demand of the testee in regard to the post-test probability of disease according with the given test result in order to rule in or out the disease and to accept or reject a particular therapeutic action. In other words, the test result does not change the degree of un certainty of presence or absence of the target disease: the test is useless. It is not because the association between a test result and the presence or absence of the disease is weak that the test is necessarily useless since a high pre-test probability and/or a ‘low’ degree of demanded certainty by tester and/or testee can make a test with a weak relation a modest likelihood ratio to the target disease useful allow to decide to the presence or absence of the target disease given a positive test result despite the weak relationship. On the other hand a test result on a test showing a strong association with the absence or presence of the target disease can be useless because of a ‘low’ pre-test probabil...
https://en.wikipedia.org/wiki/Diagnostic_test
*  Pathognomonic
A pathognomonic sign is a particular sign whose presence means that a particular disease is present beyond any doubt. Practical use Examples See also References External links. A pathognomonic sign or symptom has very high specificity but does not need to have high sensitivity : for example it can sometimes be absent in a certain disease, since the term only implies that, when it is present, the doctor instantly knows the patient's illness. The presence of a pathognomonic finding allows immediate diagnosis, since there are no other conditions in the differential diagnosis. Singular pathognomonic signs are relatively uncommon. Examples of pathognomonic findings include Koplik's spots inside the mouth in measles, the palmar xanthoma ta seen on the hands of people suffering from hyperlipoproteinemia, Negri bodies within brain tissue infected with rabies, or a tetrad of rash, arthralgia, abdominal pain and kidney disease in a child with Henoch-Schönlein purpura. As opposed to symptom s reported subjectively by th...
https://en.wikipedia.org/wiki/Pathognomonic
*  [Oral glucocorticoid-induced psychiatric side-effects: Focus on clinical specificities, incidence, r
PDF Download Available. For full functionality of ResearchGate it is necessary to enable JavaScript. Here are the instructions how to enable JavaScript in your web browser. Article. A Ricoux. A Ricoux. Remove suggestion. M Guitteny-Collas. M Guitteny-Collas. Remove suggestion. Anne Sauvaget. Anne Sauvaget Hospital Universitari de Bellvitge Message author. Remove suggestion. P Delvot. P Delvot. Remove suggestion. P Pottier. P Pottier. Remove suggestion. M Hamidou. M Hamidou. Remove suggestion. Service de psychiatrie 4, hôpital Saint-Jacques, CHU de Nantes, 85, rue Saint-Jacques, 44093 Nantes cedex 1, France. Electronic address:. La Revue de Médecine Interne. Impact Factor: 1.07. 01/2013; Source: PubMed. ABSTRACT Oral glucocorticoids have been used for several decades and psychiatric side-effects may occur. This review will discuss relevant data of the clinical specificities, the incidence, the risk factors for the occurrence of these episodes and the preventive and curative medications of these episodes. We pe...
http://researchgate.net/publication/235395164_Oral_glucocorticoid-induced_psychiatric_side-effects_Focus_on_clinical_specificities_incidence_risk_factors_and_treatment
*  "Analyze This" - A Diagnostic Assessment Analytical Essay 122939
Analyze This - A Diagnostic Assessment Analytical Essay 122939. Australia Canada France United Kingdom United States. Sell your papers. Analytical Essay. Analyze This - A Diagnostic Assessment. "Analyze This" - A Diagnostic Assessment Analytical Essay by ResearchRiter. "Analyze This" - A Diagnostic Assessment. Psychological assessment of the main character in the film "Analyze This." # 122939. APA. This paper presents a diagnostic assessment, treatment plan, and competency-based assessment for a fictional character in the movie "Analyze This". The assessment is based on a detailing and discussion of symptoms in relation to APA diagnostic criteria. The treatment plan provides a set of techniques and measurable goals that address the diagnostic issues. "This paper presents a diagnostic assessment, treatment plan and competency-based assessment for a fictional character in a movie. The conducted assessment is based on a detailing and discussion of symptoms in relation to APA diagnostic criteria. The treatment pl...
http://academon.com/analytical-essay/analyze-this-a-diagnostic-assessment-122939/
*  Assay sensitivity
If a trial intended to demonstrate efficacy by showing superiority of a test intervention to control lacks assay sensitivity, it will fail to show that the test intervention is superior and will fail to lead to a conclusion of efficacy. In contrast, if a trial intended to demonstrate efficacy by showing a test intervention is non-inferior to an active control lacks assay sensitivity, the trial may find an ineffective intervention to be non-inferior and could lead to an erroneous conclusion of efficacy. The chosen margin of inferiority in a non-inferiority trial cannot be larger than the largest effect size which the control intervention reliably and reproducibly demonstrates compared to placebo or no treatment in past superiority trials. For instance, if there is reliable and reproducible evidence from previous superiority trials of an effect size of 10% for a control intervention compared to placebo, an appropriately designed non-inferiorty trial designed to rule out that the test intervention may be as much...
https://en.wikipedia.org/wiki/Assay_sensitivity
*  ITC, Sensitivity and Overheads | Gemini Observatory
ITC, Sensitivity and Overheads. Gemini Observatory. Gemini Observatory: Exploring The Universe, Sharing its Wonders Science. Public/Images. About. Careers. Contact. Navigation. Announcements enewscast Library PIO Sciops Gemini Home Telescopes and Sites Science Visitors at Gemini Observing With Gemini Instruments Retired Instruments NORTH ALTAIR GMOS Status and Availability Nod and Shuffle Imaging Spectroscopy Overview Long-slit Spectroscopy Multi-Object Spectroscopy Integral Field Spectroscopy ITC, Sensitivity and Overheads GMOS-N ITC GMOS-S ITC Sensitivity Table Imaging Sensitivity Table Spectroscopy Atmospheric Differential Refraction Overheads. Guiding Options Calibration Observation Preparation Data Format and Reduction Documents. GNIRS NIFS NIRI GRACES SOUTH FLAMINGOS-2 GeMS GMOS GPI GSAOI VISITING Interface Specs for VI Visiting Instrument Policy DSSI Speckle Camera TEXES North RESOURCES Integration Time Calculators Magnitudes and Fluxes Near-IR Resources Mid-IR Resources Observing Condition Constraints...
http://gemini.edu/node/11673?q=node/10373
*  ITC, Sensitivity and Overheads | Gemini Observatory
ITC, Sensitivity and Overheads. Gemini Observatory. Gemini Observatory: Exploring The Universe, Sharing its Wonders Science. Public/Images. About. Careers. Contact. Navigation. Announcements enewscast Library PIO Sciops Gemini Home Telescopes and Sites Science Visitors at Gemini Observing With Gemini Instruments Retired Instruments NORTH ALTAIR GMOS Status and Availability Nod and Shuffle Imaging Spectroscopy Overview Long-slit Spectroscopy Multi-Object Spectroscopy Integral Field Spectroscopy ITC, Sensitivity and Overheads GMOS-N ITC GMOS-S ITC Sensitivity Table Imaging Sensitivity Table Spectroscopy Atmospheric Differential Refraction Overheads. Guiding Options Calibration Observation Preparation Data Format and Reduction Documents. GNIRS NIFS NIRI GRACES SOUTH FLAMINGOS-2 GeMS GMOS GPI GSAOI VISITING Interface Specs for VI Visiting Instrument Policy DSSI Speckle Camera TEXES North RESOURCES Integration Time Calculators Magnitudes and Fluxes Near-IR Resources Mid-IR Resources Observing Condition Constraints...
http://gemini.edu/node/171?q=node/10373
*  Evaluation of studies of assessment and screening tools, and diagnostic tests -- Jull 5 (3): 68 -- E
Evaluation of studies of assessment and screening tools, and diagnostic tests -- Jull 5 3 : 68 -- Evidence-Based Nursing. Current issue. Current issue. Evaluation of studies of assessment and screening tools, and diagnostic tests Andrew Jull , RN, MA. Studies of diagnostic tests and screening tools can be quite difficult to locate. Specialist databases such as the Cochrane Library do not include studies of diagnostic testing, so you do the following search on Medline OVID : *Depression/di *Depressive disorder/di Questionnaires/ 1 OR 2 AND 3 303 articles are identified. Prevalence of depression was 18%. If the first test is negative and the participant does not receive the gold standard test to verify this result, then the study results will be distorted. With respect to screening for depression, Whooley et al found several instruments with similar results, but the simplest instrument was the 2 question instrument. The 2 question case finding instrument correctly identified 94 of these 97 patients 94/97 or 0.9...
http://ebn.bmj.com/content/5/3/68.full?cited-by=yes&legid=ebnurs;5/3/68
*  Melrose-Wakefield Hospital Implements New Diagnostic Tools
Discuss Melrose-Wakefield Hospital Implements New Diagnostic Tools Sun, 04 Oct 2015 11:20:36 +0000...
http://hallmarkhealth.org/feed/com_content/387
*  www.ccforum.com - Table
www ccforum com table table sensitivity specificity positive predictive value and negative predictive value for infection markers in diagnosing bacteremia sensitivity specificity ppv npv crp level wbc count neutrophil count lymphocyte count nlcr sensitivity specificity positive predictive value ppv and negative predictive value npv of the c reactive protein crp level cut off mg l white blood cell wbc count cut off l or l neutrophil count cut off l lymphocyte count cut off l and the neutrophil lymphocyte count ratio nlcr cut off in diagnosing bacteremia de jager et al critical care r doi cc...
http://ccforum.com/content/14/5/R192/table/T4
*  Jemmco LLC, Dyne Pens & Solutions, Silicone Sleeves for Corona Treatment, Laboratory Equipment Suppl
Jemmco LLC, Dyne Pens Solutions, Silicone Sleeves for Corona Treatment, Laboratory Equipment Supplies. Login. search. View Cart. 0 Products By Category. Cleaning Products. Corona Treating Products. Dyne Test Products. Extrusion Products. Recycling Equipment. Hole Punching Perforating. Quality Control Products. Rollers Roller Coverings. Static Elimination Products. Slitter/Winders. Tapes Roller Wraps. Web Cleaning. MSDS Sheets Dyne Solutions. JemmcleanTR. Little Effort Cleaner. EZ-Read Poly Test Pen. Now In: Welcome to Jemmco, LLC. Jemmco is a leading supplier to the extrusion and web converting industries. Our products, JemmTron Corona Treater Roll Coverings, JemmTac Web Cleaning Roller Coverings, JemmTrac Traction Roller Coverings and JemmSil Release Roller Coverings have put us in the forefront of Roller Covering technology. Our line of Dyne Test Products contain the largest variety, including Accu-Flo Felt Tip Dyne Pens, Accu-Flo Jumbo Dyne Markers and EZ-READ PolyTest Dyne Pens, which enables us to be cap...
http://jemmco.com/
*  Likelihood ratios in diagnostic testing
... Calculation Application to medicine Example Estimation of pre- and post-test probability Example. Respectively, they are known as the ' LR+, 'likelihood ratio positive', 'likelihood ratio for positive results' and ' LR–, 'likelihood ratio negative', 'likelihood ratio for negative results'. The positive likelihood ratio is calculated as. or "the probability of a person who has the disease testing positive divided by the probability of a person who does not have the disease testing positive." Here "T+" or "T " denote that the result of the test is positive or negative, respectively. So "true positives" are those that test positive T+ and have the disease D+, and "false positives" are those that test positive T+ but do not have the disease D. 5 : LR- = \frac{1 - \text{sensitivity}}{\text{specificity}}. or "the probability of a person who has the disease testing negative divided by the probability of a person who does not have the disease testing negative.". Pretest odds = Pretest probability / 1 - Pretest p...
https://en.wikipedia.org/wiki/Likelihood_ratios_in_diagnostic_testing
*  Indeterminate Result
... HIV Prevention and Testing. Indeterminate Result. HIV Prevention and Testing Am I Infected. Stats Total Posts: 675753 Total Topics: 52429 Online Today: 186 Online Ever: 585 January 07, 2014, 02:31:47 PM. Logged Infected September s 2012 Seroconverted October 2012 Elisa test- indeterminate 20th November. 2012 Rapid test - Negative 23th November 2012 Elisa test - Positive 10th December 2012 CD4 - 546, 12th Dec 2012 CD4 600+, VL 6702 26th March 2013. The vast majority of people who have actually been infected will seroconvert and test positive by six weeks, with the average time to seroconversion being only 22 days. Even if this incident occurred at the end of September, if you were positive, you most likely would have had a firm positive result by now, not an indeterminate. Only a three month negative test will be conclusive and as I already stated, if you continue to get indeterminate results, your doctor needs to investigate other possible causes. If you get a positive result, you need to know that you w...
http://forums.poz.com/index.php?topic=46391.0;prev_next=next
*  Emisson control light on. DIAGNOSTIC RESULTS ADDED (from breakdown people) | Audi-Sport.net
Emisson control light on. Audi-Sport.net. Forums. Search Forums. Recent Posts. Resources. Search Resources. Most Active Authors. Most Active Members. Parts Request. Submit New Parts Request. Events. Upcoming Events. Events Archive. Members. Notable Members. Registered Members. Groups. VCDS Map. The Trading Post. Group Buy / Discount Forum. Classifieds. For Sale/Wanted - Audi Cars. For Sale/Wanted - Audi Parts. For Sale/Wanted - Miscellaneous. For Sale/Wanted - Other Make Cars Parts. Classifieds-Bin. Classifieds Disputes. Password. Likes You've Received. Log Out. Forums. Forums Quick Links. Search Forums. Recent Posts. Posted by Member:. Search this forum only. Recent Posts. Resources. Resources Quick Links. Search Resources. Garage Reviews Quick Links. Most Active Members. Gallery Quick Links. DIAGNOSTIC RESULTS ADDED from breakdown people Discussion in ' Q3, RSQ3 Q5, SQ5 Q7 Forum ' started by quattro25years, Apr 19, 2013. with the engine running it sounds like there is a throbbing noise coming from the exhau...
http://audi-sport.net/xf/threads/emisson-control-light-on-diagnostic-results-added-from-breakdown-people.186687/
*  Sophos Diagnostic Utility (SDU): ダウンロードとインストール方法
Sophos Diagnostic Utility SDU : ダウンロードとインストール方法. Network Protection Enduser Protection Server Protection UTM. Secure Web Gateway. Secure Email Gateway. Server Security. Secure Login Sign In Pick a destination and sign in. Sophos Diagnostic Utility SDU : ダウンロードとインストール方法. 重要: Windows 上でユーティリティを実行する際に次のメッセージが表示された場合: This version of the Sophos Diagnostic Utility is no longer supported.Please download the latest version. Sophos Diagnostic Utility を実行する をご覧ください. 影響を受けるソフォス製品とバージョン Sophos Diagnostic Utility ソフォスのエンドポイント製品に含まれている SDU を見つける Sophos Diagnostic Utility はソフォスのエンドポイントのパッケージの一部としてダウンロードされています. コンピュータで C:\ProgramData\Sophos\Autoupdate\Cache\savxp\diagnose\ を参照します. コンピュータで C:\Program Files\Sophos\Autoupdate\Cache\savxp\diagnose\ を参照します. コンピュータで C:\Documents and Settings\All Users\Application Data\Sophos\Autoupdate\Cache\savxp\diagnose\ を参照します. ソフトウェアの配布場所から SDU を直接実行する Sophos Diagnostic Utility は、Endpoint Security and Control バージョン 10 以降の Sophos Update Manager SUM によってダウンロードされる Windows パッケージに含まれています。Sophos D...
https://sophos.com/ja-jp/support/knowledgebase/33533.aspx
*  CHEST Journal | Article
For detecting adrenal and/or liver metastases, the summary NPV of the clinical evaluation was 0.95 95% CI, 0.93 to 0.96, and for detecting bone metastases, it was 0.90 95% CI, 0.86 to 0.93. 5 For studies that included patients with a positive and negative clinical evaluation, the sensitivity, specificity, and PPV of the evaluation for metastatic disease were calculated. With gadolinium, the sensitivity was 1.0, the specificity was 0.91, the PPV was 0.96, and the NPV was 1.0. 68 assessed the ability of the clinical evaluation to detect adrenal and/or liver metastases in 1,201 patients Table 5. 73 assessed the ability of clinical evaluation to detect bone metastases in 633 patients Table 6. The pooled sensitivity and specificity of clinical bone evaluation for detecting bone metastases were 0.87 95% CI, 0.79 to 0.93 and 0.67 95% CI, 0.40 to 0.88, respectively. However, the NPV and PPV of a test are affected by the prevalence of disease. Other studies 11 have demonstrated improved sensitivity and specificity for...
http://journal.publications.chestnet.org/article.aspx?articleid=1081262
*  ITC, Sensitivity and Overheads | Gemini Observatory
ITC, Sensitivity and Overheads. Gemini Observatory. Gemini Observatory: Exploring The Universe, Sharing its Wonders. Science. Public/Images. About. Careers. Contact. Navigation. Announcements enewscast Library PIO Sciops. Gemini Home Telescopes and Sites Science Visitors at Gemini Observing With Gemini Instruments. Retired Instruments NORTH ALTAIR GMOS GNIRS. Status and Availability Spectroscopy Imaging ITC, Sensitivity and Overheads. GNIRS ITC Sensitivity Table Overheads Saturation and the ITC. Guiding Options Calibration Observation Preparation Data Format and Reduction System Verification Documents NIR Resources. NIFS NIRI GRACES SOUTH FLAMINGOS-2 GeMS GMOS GPI GSAOI VISITING Interface Specs for VI Visiting Instrument Policy DSSI Speckle Camera TEXES North RESOURCES Integration Time Calculators Magnitudes and Fluxes Near-IR Resources Mid-IR Resources Observing Condition Constraints Performance Monitoring SV/Demo Science. Future Instrumentation Current Development Queue and Schedules Data and Results Helpde...
http://gemini.edu/node/12062?q=node/10509
*  ITC, Sensitivity and Overheads | Gemini Observatory
ITC, Sensitivity and Overheads. Gemini Observatory. Gemini Observatory: Exploring The Universe, Sharing its Wonders. Science. Public/Images. About. Careers. Contact. Navigation. Announcements enewscast Library PIO Sciops. Gemini Home Telescopes and Sites Science Visitors at Gemini Observing With Gemini Instruments. Retired Instruments NORTH ALTAIR GMOS GNIRS. Status and Availability Spectroscopy Imaging ITC, Sensitivity and Overheads. GNIRS ITC Sensitivity Table Overheads Saturation and the ITC. Guiding Options Calibration Observation Preparation Data Format and Reduction System Verification Documents NIR Resources. NIFS NIRI GRACES SOUTH FLAMINGOS-2 GeMS GMOS GPI GSAOI VISITING Interface Specs for VI Visiting Instrument Policy DSSI Speckle Camera TEXES North RESOURCES Integration Time Calculators Magnitudes and Fluxes Near-IR Resources Mid-IR Resources Observing Condition Constraints Performance Monitoring SV/Demo Science. Future Instrumentation Current Development Queue and Schedules Data and Results Helpde...
http://gemini.edu/sciops/observing-gemini/partner-subscription/oversubscription-rates?q=node/10509
*  ITC, Sensitivity and Overheads | Gemini Observatory
ITC, Sensitivity and Overheads. Gemini Observatory. Gemini Observatory: Exploring The Universe, Sharing its Wonders. Science. Public/Images. About. Careers. Contact. Navigation. Announcements enewscast Library PIO Sciops. Gemini Home Telescopes and Sites Science Visitors at Gemini Observing With Gemini Instruments. Retired Instruments NORTH ALTAIR GMOS GNIRS. Status and Availability Spectroscopy Imaging ITC, Sensitivity and Overheads. GNIRS ITC Sensitivity Table Overheads Saturation and the ITC. Guiding Options Calibration Observation Preparation Data Format and Reduction System Verification Documents NIR Resources. NIFS NIRI GRACES SOUTH FLAMINGOS-2 GeMS GMOS GPI GSAOI VISITING Interface Specs for VI Visiting Instrument Policy DSSI Speckle Camera TEXES North RESOURCES Integration Time Calculators Magnitudes and Fluxes Near-IR Resources Mid-IR Resources Observing Condition Constraints Performance Monitoring SV/Demo Science. Future Instrumentation Current Development Queue and Schedules Data and Results Helpde...
http://gemini.edu/sciops/observing-gemini/partner-subscription?q=node/10509
*  Monitoring Immunity Through Diagnostics
... print. close. Monitoring Immunity Through Diagnostics. Jeff Zimmerman, DVM and Eileen Thacker, DVM Iowa State University Tue, 2003-04-15 12:00 Diagnostic tests are direct measures of exposure or vaccination, and indirect meastures of immunity. Diagnostic assays or tests are tools used by producers and veterinarians to assess the disease and immune status of pigs. Depending on the specific diagnostic assay, laboratory tests detect antibodies or proteins that are produced in large quantities by the pig in an immune response to an infection or the presence of an infectious agent. Immunity is essentially the pig's resistance to infection. Diagnostic assays do not measure immunity. Rather, they look for evidence of disease exposure in response to vaccination, antibodies or infectious agents. In terms of immunity, the underlying assumption is that prior infection or vaccination has stimulated an immune response that will provide some level of protection from disease symptoms in the future. For these reasons, d...
http://nationalhogfarmer.com/print/mag/farming_monitoring_immunity_diagnostics
*  Fluctuating fever for 5 days, all tests negative -Doctors Lounge(TM)
Fluctuating fever for 5 days, all tests negative -Doctors Lounge TM. Search for:. News. Journals. Conferences. Blogs. Articles. Forums. Twitter. Home. Ask a Doctor. Medical Professional. Author. Volunteer. Medical Reference. Diseases. Symptoms. Labs. Procedures. Drugs. Medical Specialty. Cardiology. Dermatology. Endocrinology. Fertility. Gastroenterology. Gynecology. Hematology. Infections. Nephrology. Neurology. Oncology. Orthopedics. Pediatrics. Pharmacy. Primary Care. Psychiatry. Pulmonology. Rheumatology. Surgery. Urology. More ... Headlines:. Doctors Lounge - Infections Answers The information provided on www.doctorslounge.com is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her physician. Back to Infections Answers List Forum Name: Other infections Question: Fluctuating fever for 5 days, all tests negative c alcazar - Tue Sep 23, 2008 9:39 pm. Share. Hi, A friend of mine has had fever for the last 5 days. The fever comes back at specific times of t...
http://doctorslounge.com/infections/forums/backup/topic-25518.html
*  www.diagnosticpathology.org - Table
www diagnosticpathology org table table sensitivity specificity positive predictive value and negative predictive value of combined expression of ck and muc according to the histological type histological type maker sensitivity specificity ppv npv intestinal type ck muc pancreatobiliary type ck muc unusual type ck muc ppv positive predictive value npv negative predictive value kawabata et al diagnostic pathology doi...
http://diagnosticpathology.org/content/5/1/75/table/T4
*  Lophius Wins $469K to Develop MS Diagnostic | GEN News Highlights | GEN
Lophius Wins $469K to Develop MS Diagnostic. Jobs Report: Data, Business, and Regulatory Savvy Driving New Hiring. Jobs Report: Data, Business, and Regulatory Savvy Driving New Hiring. Market & Tech Analysis. GEN News Highlights More » Jun 19, 2013 Lophius Wins $469K to Develop MS Diagnostic Page 1 of 1 Lophius Biosciences won 350,000 about $469,000 over two years from Germany s Federal Ministry of Education and Research BMBF to develop a blood-based diagnostic test, after joining Germany s NEU 2 academic-industry research consortium. The diagnostic uses the company s Reverse T-Cell Technology RTT platform technology, which unlike current diagnostic methods exploits the maturation processes induced in antigen-presenting cells through interaction with activated T helper Th cells. Due to the high specificity of RTT for activated Th cells, the RTT assay is designed for reliable detection of disease-specific activated Th cells as a biomarker for diagnosis and monitoring of MS and other ongoing autoimmune diseases...
http://genengnews.com/gen-news-highlights/lophius-wins-469k-to-develop-ms-diagnostic/81248502/?kwrd=Molecular Diagnostics
*  Lophius Wins $469K to Develop MS Diagnostic | GEN News Highlights | GEN
Lophius Wins $469K to Develop MS Diagnostic. Linking Phenotypes and Modes of Action Through High-Content Screen Fingerprints. Jobs Report: Data, Business, and Regulatory Savvy Driving New Hiring. Linking Phenotypes and Modes of Action Through High-Content Screen Fingerprints. Jobs Report: Data, Business, and Regulatory Savvy Driving New Hiring. Market & Tech Analysis. Linking Phenotypes and Modes of Action Through High-Content Screen Fingerprints The Use of High-Content Screening as... GEN News Highlights More » Jun 19, 2013 Lophius Wins $469K to Develop MS Diagnostic Page 1 of 1 Lophius Biosciences won 350,000 about $469,000 over two years from Germany s Federal Ministry of Education and Research BMBF to develop a blood-based diagnostic test, after joining Germany s NEU 2 academic-industry research consortium. The diagnostic uses the company s Reverse T-Cell Technology RTT platform technology, which unlike current diagnostic methods exploits the maturation processes induced in antigen-presenting cells throug...
http://genengnews.com/gen-news-highlights/lophius-wins-469k-to-develop-ms-diagnostic/81248502/?kwrd=Financing
*  Sensitivity Analysis - Tests, Test Results & Diagnosis - NY Times Health Information
Sensitivity Analysis - Tests, Test Results Diagnosis - NY Times Health Information. Log In Register Now Help. Home Page Today's Paper Video Most Popular Times Topics. Search All NYTimes.com. Health Guide. World U.S. N.Y. / Region Business Technology Science Health Research Fitness Nutrition Money Policy Views Health Guide. Sports Opinion Arts Style Travel Jobs Real Estate Autos. Search Health 3,000+ Topics. Send Feedback. Health. Times Health Guide. s. Sensitivity Analysis. Sensitivity Analysis. Overview Alternative Names How the Test Is Performed How to Prepare for the Test How the Test Will Feel Why the Test Is Performed What Abnormal Results Mean Risks References. Related Topics. Blood Culture Urine Culture Urine Culture - Catheterized Specimen Routine Sputum Culture Culture - Endocervix Throat Swab Culture. Sensitivity analysis determines the effectiveness of antibiotics against microorganisms germs such as bacteria that have been isolated from cultures. Sensitivity analysis may be done along with: Blood ...
http://nytimes.com/health/guides/test/sensitivity-analysis/overview.html
*  SroC RNA
... infobox rfam name sroc rna image rf jpg width caption predicted secondary structure and sequence conservation of sroc symbol sroc altsymbols rfam rf mirbase mirbase family rna type gene srna tax domain bacteria go so cas number entrezgene hgncid omim pdb refseq chromosome arm band locussupplementarydata the bacterial sroc rna is a non coding rna gene of around nucleotides in length sroc is found in several enterobacterial species but its function is unknown this rna interacts with the hfq protein references external links category non coding rna...
https://en.wikipedia.org/wiki/SroC_RNA
*  Laboratory tube
... s are pieces of laboratory equipment used to hold small quantities of substances undergoing experimentation or testing they are usually made of glass and vary in size and purpose laboratory tubes must not be confused with glass tubing which is used to carry gases between laboratory equipment the main examples of laboratory tube are listed below ignition tube test tube boiling tube nmr tube see also laboratory glassware category laboratory equipment...
https://en.wikipedia.org/wiki/Laboratory_tube
*  Mouse Sensitivity
... frictional games forum newsletter dev blog dev wiki support search member list irc help current time pm hello there guest login register frictional games forum penumbra overture black plague requiem hints help and spoilers previous next mouse sensitivity threaded mode linear mode mouse sensitivity author message cradleofvalentine junior member posts joined apr reputation post mouse sensitivity hello all for some reason i thought i would check out the mouse sensitivity on the highest option i don t like this setting so i want to change it back but can t figure out how i click on the mouse sensitivity option but nothing happens can t drag it to change anyone help i use a mac pm next oldest next newest messages in this thread mouse sensitivity cradleofvalentine pm re mouse sensitivity jens am view a printable version send this thread to a friend subscribe to this thread user s browsing this thread guest s contact us frictional games return to top return to content lite archive mode rss syndication powered b...
http://frictionalgames.com/forum/showthread.php?mode=threaded&tid=14412&pid=127851
*  B-Cells - Why one specificity?
b cells why one specificity b cells why one specificity bob scibienski rjscibienski at ucdavis edu tue dec est previous message b cells why one specificity next message b cells why one specificity messages sorted by in fact two specificities equates with four possible l h chain combinations so the waste grows exponentionally bob s john richard seavitt jrseavit at artsci wustl edu wrote on tue dec andrew louka wrote why one b cell one specificity why not have multiple specificities per b cell surely this would have been more effective and energy efficient nope then you d have b cells with two or more specific surface immunologlobins since the b cell couldn t distinquish which one it got activated through it would presumably behave as if all of its receptor specificities had been activated it would await t cell help proliferate and differentiate into plasma cells of course it would now be spending the metabloic energy to produce two or more specific secreted antibodies of course the odds that the appropriate an...
http://bio.net/bionet/mm/immuno/1997-December/011419.html
*  ryanb/vcr · GitHub
... Skip to content. Sign up Sign in. This repository. Explore. Features. Enterprise. Pricing. Watch. 1. Star. 2. Fork. 277. ryanb. / vcr. forked from vcr/vcr. Code Pull requests. Pulse Graphs HTTPS clone URL. Subversion checkout URL. You can clone with. . HTTPS or. . Subversion. Download ZIP. Record your test suite's HTTP interactions and replay them during future test runs for fast, deterministic, accurate tests. http://relishapp.com/myronmarston/vcr. 947 commits. 4 branches. 40 releases. Fetching contributors Ruby 100.0%. Ruby. Branch: master. Switch branches/tags. Branches. Tags. 1-x-stable. jruby nailgun. master. readme-contributing-link. Nothing to show. v2.0.0.beta2. v2.0.0.beta1. v1.11.3. v1.11.2. v1.11.1. v1.11.0. v1.10.3. v1.10.2. v1.10.1. v1.10.0. v1.9.0. v1.8.0. v1.7.2. v1.7.1. v1.7.0. v1.6.0. v1.5.1. v1.5.0. v1.4.0. v1.3.3. v1.3.2. v1.3.1. v1.3.0. v1.2.0. v1.1.2. v1.1.1. v1.1.0. v1.0.3. v1.0.2. v1.0.1. v1.0.0. v0.4.1. v0.4.0. v0.3.1. v0.3.0. v0.2.0. v0.1.2. v0.1.1. v0.1.0. semver. Nothing to sho...
https://github.com/ryanb/vcr
*  Moldmaker Explores New LSR Molding Technologies : Products Fi
... nishing. Articles Moldmaker Explores New LSR Molding Technologies Moldmaker Explores New LSR Molding Technologies Article From: Plastics Technology, Matthew H. CLICK IMAGE TO ENLARGE + PP water vial is molded in a two-shot Engel victory combi press in a prototype mold at Roembke. PP is injected in the right-hand cavity and then transferred by a robot to the left-hand cavity where the LSR plug is overmolded into the bottom center of the vial. Overmolded LSR plug circular insert at center of the vial’s base is a critical element for UV optical detection of bacterial growth after incubation. Overmolding LSR onto PP is a rare feat because of the 340 F cure temperature of the LSR, above the 245 F HDT of the PP. Roembke is experimenting with pressurized hot-water mold heating, using this Single TCU capable of up to 392 F/200 C as a clean and more reliable alternative to electrical cartridge heaters. Roembke is unusual for a moldmaker in having six Arburg and Engel LSR injection presses permanently on site, one ...
http://pfonline.com/articles/moldmaker-explores-new-lsr-molding-technologies
*  Triagem nutricional - Resumos Diversos - Fernandaromano
Pesquisar trabalhos. Triagem nutricional Disponível somente no TrabalhosFeitos Páginas : 7 1727 palavras. Materiais e Métodos: Nesse estudo transversal, cinco instrumentos de triagem nutricional foram aplicados aos pacientes nas primeiras 48 horas de internação hospitalar. Aocorrência de risco nutricional entre adultos e idosos foi comparada. Quanto ao tempo médio gasto para a aplicação dosinstrumentos, observou-se certa concordância entre eles, todavia a MNA foi o instrumento que requereu maior tempo para aplicação. Materials and Methods: A cross-sectional study, with the application of nutritional screening tools in adult and elderly patients in the first 48 hours of hospitalization was performed. In relation to the time of application, the MNA was the instrument with longer application time. Conclusion: Considering the higher detection of patients with nutritional risk, the easiness and the lower application time, we suggest, respectively, MUST and MNA-SF to be used in adult andelderly patients admitted in...
http://trabalhosfeitos.com/ensaios/Triagem-Nutricional/487170.html
*  GeneAnnot Search
... an academic website of the in association with geneannot home overview what s new custom cdfs publications team select affymetrix microarray version s hg u hg u hg u plus search by probe set s search by gene symbol search by genecards id at geneannot results for hg u plus probe set array annotation quality best resource gene symbol gene description chromosomal location sensitivity specificity number of genes at u plus genecards snca synuclein alpha non a component of amyloid precursor chr bp...
http://genecards.weizmann.ac.il/cgi-bin/geneannot/GA_search.pl?keyword_type=probe_set_list&keyword=236081_at&array=HG-U133_Plus_2&target=integrated&.submit=Submit Query
*  STI testing
... redirect sexually transmitted infection diagnosis...
https://en.wikipedia.org/wiki/STI_testing
*  File:Relationship between asset specificity.JPG
file relationship between asset specificity jpg file relationship between asset specificity jpg summary relationship between asset specificity uncertainty and governance structure licensing...
https://en.wikipedia.org/wiki/File:Relationship_between_asset_specificity.JPG
*  Confirmatory diagnosis
... redirect presumptive and confirmatory tests...
https://en.wikipedia.org/wiki/Confirmatory_diagnosis
*  ..
Testing Confirmation...
http://columbiafertility.org/fertility-services/ivf/
*  M.tuberculosis Pantothenate Kinase: Dual Substrate Specificity and Unusual Changes in Ligand Locati
... ons - ePrints@IISc. . Home. About. Browse. Latest Additions. Advanced Search. Contact. Help. Login. Create Account. M.tuberculosis Pantothenate Kinase: Dual Substrate Specificity and Unusual Changes in Ligand Locations. Chetnani, Bhaskar and Kumar, Parimal and Surolia, A and Vijayan, M 2010 M.tuberculosis Pantothenate Kinase: Dual Substrate Specificity and Unusual Changes in Ligand Locations. In: Journal of Molecular Biology, 400 2. pp. 171-185. PDF jmb.pdf - Published Version Restricted to Registered users only Download 3030Kb. Request a copy. Official URL: http://dx.doi.org/10.1016/j.jmb.2010.04.064 Abstract Kinetic measurements of enzyme activity indicate that type I pantothenate kinase from Mycobacterium tuberculosis has dual substrate specificity for ATP and GTP, unlike the enzyme from Escherichia coli, which shows a higher specificity for ATP. A molecular explanation for the difference in the specificities of the two homologous enzymes is provided by the crystal structures of the complexes of the M....
http://eprints.iisc.ernet.in/31083/
*  20% Store-Wide SALE! Also, 3-8pm cst each day a different product 40% off! - Page 3
20% Store-Wide SALE. Also, 3-8pm cst each day a different product 40% off. Today's Posts. Also, 3-8pm cst each day a different product 40% off. Thread: 20% Store-Wide SALE. Also, 3-8pm cst each day a different product 40% off. 08-17-2012, 06:52 PM. RUI-products. Official Sponsor. Join Date Sep 2009 Location www.rui-products.com Posts 7,612. Rep Power 10. Originally Posted by RUI-products. Today's 3-8pm cst 40% off SALE. Peptides are now 25% off Quality, Made in the USA Peptides for Less and the rest of the store is 20% off. Save big time dollars. RUI. Follow us on Instagram. twitter. Reply With Quote. RUI-products. Official Sponsor. Join Date Sep 2009 Location www.rui-products.com Posts 7,612. Rep Power 10. Today's 3-8pm cst 40% off SALE. Peptides are now 25% off Quality, Made in the USA Peptides for Less and the rest of the store is 20% off. Save big time dollars. RUI. Follow us on Instagram. twitter. Reply With Quote. 08-18-2012, 06:34 PM. RUI-products. Official Sponsor. Join Date Sep 2009 Location www.rui-...
http://steroidology.com/forum/peptide-science/630502-20-store-wide-sale-also-3-8pm-cst-each-day-different-product-40-off-3.html
*  Enzymatic Product release question
... taguebw at wfu edu taguebw at wfu edu tue sep est previous message enzymatic product release question next message quantifying cell proliferation messages sorted by william p tschantz wrote i am looking for examples of any proteins that the product does not dissociate from the enzyme till either new substrate binds or someother protein accepts the product from the enzyme i am not aware of anything out in the literature but then i do not know what type of search words to use in a literature search of the above topic any help greatly apprecieated you might try searching for channelling referring to the process by which products are passed along or channeled to the next enzyme try these references negrutskii boris s and murray p deutscher channeling of aminoacyl trna for protein synthesis in vivo pnas negrutskii boris s and murray p deutscher a sequestered pool of aminoacyl trna in mammalian cells pnas negrutskii boris s romualdas stapulionis and murray p deutscher supramolecular organization of the mammali...
http://bio.net/bionet/mm/cellbiol/1996-September/005238.html
*  Specificity constant
... In the field of biochemistry, the 'specificity constant' also called 'kinetic efficiency' or k {cat}/K {M}, is a measure of how efficiently an enzyme converts substrates into products. A comparison of specificity constants can also be used as a measure of the preference of an enzyme for different substrates i.e., substrate specificity. The higher the specificity constant, the more the enzyme "prefers" that substrate. 1 The following equation, known as the Michaelis–Menten model, is used to describe the kinetics of enzymes :. : E + S \, \overset{k f}\underset{k r} \rightleftharpoons \, ES \, \overset{k {cat}} {\longrightarrow} \, E + P. where E, S, ES, and P represent e nzyme, s ubstrate, e nzyme– s ubstrate complex, and p roduct respectively. The symbols k f, k r, and k \mathrm{cat} denote the rate constant s for the "forward" binding and "reverse" unbinding of substrate, and for the "catalytic" conversion of substrate into product respectively. The Michaelis constant in turn is defined as follows: K {M}...
https://en.wikipedia.org/wiki/Specificity_constant
*  Life Sciences Faculty - Thomas Pochapsky
Cytochrome P450 monooxygenases catalyze the selective oxidation of unactivated C-H and C-C bonds by molecular oxygen, and this activity is critical for diverse biological functions including steroid hormone biosynthesis, drug and xenobiotic metabolism and clearance, and pro-drug activation. We are the first group to apply high-resolution NMR methods to understanding structure-activity relationships in the P450 superfamily. NMR offers a unique perspective on these enzymes, as it allows atomic-resolution detail of the enzymes as they exist in solution. The P450 reaction cycle is complicated, requiring multiple substrate binding, electron and proton transfer steps, with interactions between redox partners and effector molecules leading to poorly understood conformational changes. We have identified critical and previously unrecognized conformational changes that occur during the course of the reaction cycle, and have pinpointed particular residues that are involved in those changes using NMR and mutagenesis. We ...
http://bio.brandeis.edu/faculty/pochapsky.html
*  Patente US6605153 - Coating film forming apparatus - Google Patentes
... . . . . Patentes. An apparatus includes a holding portion for holding a substrate, a nozzle, provided to face the substrate held by the holding portion, for discharging a solution to the substrate, a driver for moving the nozzle along a surface of the substrate relatively with respect to the substrate while the solution... . . . . . Fecha de prioridad 17 Dic 1999. Tarifa Caducada. . . Inventores Takahiro Kitano,. Masateru Morikawa,. Yukihiko Esaki,. Nobukazu Ishizaka,. Norihisa Koga,. Kazuhiro Takeshita,. Hirofumi Ookuma,. Masami Akimoto. Cesionario original Tokyo Electron Limited. Exportar cita BiBTeX,. EndNote,. RefMan. Citas de patentes 3,. Citada por 22,. Clasificaciones 21,. Eventos legales 5. Enlaces externos:. USPTO,. . Espacenet. Coating film forming apparatus US 6605153 B2 Resumen An apparatus includes a holding portion for holding a substrate, a nozzle, provided to face the substrate held by the holding portion, for discharging a solution to the substrate, a driver for moving the nozzle along a...
http://google.es/patents/US6605153?dq=flatulence
*  Cyclic enzyme system
... a cyclic enzyme system is a theoretical system of two enzyme s sharing a single substrate or cofactor also referred to as a biochemical switching device it has been used as a biochemical implementation of a simple computational device acting as a chemical diode see also biocomputer computational gene references category enzymes...
https://en.wikipedia.org/wiki/Cyclic_enzyme_system
*  Panasonic 14mm F2.5 review data at various sites.: Micro Four Thirds Talk Forum: Digital Photography
... Review. Reviews. Sample Images. Videos. Lenses. Forums. Forum index. Micro Four Thirds Talk Change forum Panasonic 14mm F2.5 review data at various sites. Shop cameras lenses ▾. Forum Parent First Previous Next Next unread. jericho77. Panasonic 14mm F2.5 review data at various sites. Aug 5, 2013. Reply to thread Reply with quote. Forum Parent First Previous Next Next unread. Posted by When Panasonic 14mm F2.5 review data at various sites. jericho77. Aug 5, 2013. Re: Panasonic 14mm F2.5 review data at various sites. Aug 5, 2013 3. Re: Panasonic 14mm F2.5 review data at various sites. Aug 5, 2013. Re: Panasonic 14mm F2.5 review data at various sites. Aug 5, 2013. Re: Panasonic 14mm F2.5 review data at various sites. jericho77. Aug 5, 2013. Aug 5, 2013. jericho77. Aug 5, 2013. Re: Panasonic 14mm F2.5 review data at various sites. jericho77. Aug 5, 2013. Re: Panasonic 14mm F2.5 review data at various sites. Aug 5, 2013 1. Re: Panasonic 14mm F2.5 review data at various sites. Alumna Gorp. Aug 5, 2013. ...
http://dpreview.com/forums/post/51930238
*  The genetic basis of a plant-insect coevolutionary key innovation. Proc Natl Acad Sci USA (PDF Downl
Proc Natl Acad Sci USA PDF Download Available. Proc Natl Acad Sci USA. © 2007 by The National Academy of Sciences of the USA www.pnas.org?cgi?doi?10.1073?pnas.0706229104PNAS. fossil calibrated, Bayesian relaxed molecular clock estimation of the Pierinae–Coliadinae divergence. Fossil and molecular data agree that the Brassicales appeared by 90 to 85 Mya, which is much earlier than the parallel evolution of glucosinolates in the Euphorbiaceae 58 Mya 28. In this article, we directly address the timing of the appearance of the glucosinolate-feeding Pierinae, using several independent molecular datasets and various calibration methods to generate a robust estimate of when Pieridae evolved relative to their Brassicales host plants. Pieridae-specific temporal reconstruction used a Bayesian relaxed molecular clock method on EF-1. Current and expected diversity, and divergence estimates for the Coliadinae and Pierinae subfamilies of Pieridae. However, there are significantly more species of Pierinae than expected, eve...
http://researchgate.net/publication/5771953_The_genetic_basis_of_a_plant-insect_coevolutionary_key_innovation._Proc_Natl_Acad_Sci_USA
*  Mystery of bacterial growth and resistance solved: Findings shed light on how bacteria form protecti
... ve biofilms -- ScienceDaily. Your source for the latest research news. Mystery of bacterial growth and resistance solved: Findings shed light on how bacteria form protective biofilms. Date: April 26, 2012 Source: The Scripps Research Institute Summary: Scientists have unraveled a complex chemical pathway that enables bacteria to form clusters called biofilms. Scientists at The Scripps Research Institute have unraveled a complex chemical pathway that enables bacteria to form clusters called biofilms. Past research had also revealed that nitric oxide is involved in influencing bacterial biofilm formation. Nitric Oxide Modulates Bacterial Biofilm Formation through a Multicomponent Cyclic-di-GMP Signaling Network. The Scripps Research Institute. "Mystery of bacterial growth and resistance solved: Findings shed light on how bacteria form protective biofilms." ScienceDaily. The Scripps Research Institute. Mystery of bacterial growth and resistance solved: Findings shed light on how bacteria form protective biof...
http://sciencedaily.com/releases/2012/04/120426135128.htm
*  Mankin Lab - Publications
Browse by year: 2014    2013    2012    2011    2010    2009    2008    2007    2006    2005    2004    2003    2002    2001    2000    1999    1998    1997    1996    1995   . Proc Natl Acad Sci USA 111, 9804-9809. 2014 The general mode of translation inhibition by macrolide antibiotics Proc Natl Acad Sci USA 111, 15958–15963. Top. Top. Top. Proc Natl Acad Sci USA 108, 5931-5932. Proc Natl Acad Sci USA 108, 10496-10501. Vázquez-Laslop, N., Ramu, H., Mankin, A. 2011 Nascent peptide in the ribosome exit tunnel affects functional properties of the A-Site of the peptidyl transferase center Mol Cell 41, 321-330. Top. Proc Natl Acad Sci USA 107, 1983-1988. A., Xiong, L., Mankin, A. H D 2010 Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action Proc Natl Acad Sci USA 107, 17152-...
http://mankinlab.cpb.uic.edu/cgi-bin/publication.cgi
*  GO:1900911 regulation of olefin biosynthetic process
... Services. Research. Training. Industry. About us. QuickGO A fast browser for Gene Ontology terms and annotations. EBI Databases QuickGO GO:1900911 regulation of olefin biosynthetic process. Search for terms by keyword or ID: apoptosis GO:0006915 Search for proteins by name or accession: tropomyosin P06727. Web Services. Dataset. Term Basket. Term Information ID GO:1900911. Name regulation of olefin biosynthetic process. Ontology Biological Process. Definition Any process that modulates the frequency, rate or extent of olefin biosynthetic process. GONUTS GO:1900911 Wiki Page. Synonyms. Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details. Type Synonym. exact regulation of olefin synthesis. exact regulation of olefin biosynthesis. exact regulation of olefin formation. exact regulation of olefin anabolism. Ancestor Chart This chart is interactive; ...
http://ebi.ac.uk/QuickGO/GTerm?id=GO:1900911
*  Albums by Smokey Robinson : Rhapsody
... JavaScript is disabled in your browser settings. rhapsody.com requires JavaScript. Cancel. Free trial. x Music. Apps Devices. Pricing. Sign up. Company Info. Careers. Press Media. Partners. Account. Customer Support. Redeem Coupon. Buy a Gift. 2015 Rhapsody International Inc. ×. Rhapsody App for. Rhapsody International, Inc. Get app. Have the app. Music Apps Devices Pricing Listen Now Try Rhapsody. Sign In. Home. / Music. / Soul/R B. / Motown. / Smokey Robinson. / Facebook. Twitter. Albums by Smokey Robinson. Main Releases. Play. Smokey & Friends. Smokey Robinson. Play. Be Near Me. Smokey Robinson. Play. The Motown Years Live. Smokey Robinson. Play. Ev'ry Man Should Know. Smokey Robinson. Play. The Solo Anthology. Smokey Robinson. Play. The Stripped Mixes. Smokey Robinson. Play. Time Flies When You're Having Fun. Smokey Robinson. Play. Love Songs. Smokey Robinson. Play. Timeless Love. Smokey Robinson. Play. The Definitive Collection. Smokey Robinson. Play. 20th Century Masters: The Millennium Collection....
http://rhapsody.com/artist/smokey-robinson/albums
*  Robinson News | News | News Releases | Robinson Memorial Hospital
-Any- Foundation News Robinson News. Foundation Awards Scholarships Benefitting Employees September 25, 2014 The Robinson Memorial Hospital Foundation is pleased to announce the awarding of 9 scholarships to employees of Robinson Memorial Hospital and Rob... Robinson wins NorthCoast 99 Award 12 years in a row September 4, 2014 Robinson Memorial Hospital again has been named as one of the best 99 places to work in Northeast Ohio by the Employers Resource Council. Osteoporosis event to celebrate healthy aging month September 4, 2014 During Robinson Memorial Hospital’s celebration of healthy aging month, there will be a program on Osteoporosis on Wednesday, September 10 from 6 ... Foundation Awards Student Scholarships July 10, 2014 The Robinson Memorial Hospital Foundation is pleased to announce the award of seven scholarships to children of Robinson Memorial Hospital and Robi... Robinson Wound Care Center Joins Healogics, Inc. to Raise Awareness of Chronic Wounds May 29, 2014 The Robinson Wound Care Center at ...
http://robinsonmemorial.org/main/news-releases/451.aspx?email=1
*  Robinson News | News | News Releases | Robinson Memorial Hospital
-Any- Foundation News Robinson News. Foundation Awards Scholarships Benefitting Employees September 25, 2014 The Robinson Memorial Hospital Foundation is pleased to announce the awarding of 9 scholarships to employees of Robinson Memorial Hospital and Rob... Robinson wins NorthCoast 99 Award 12 years in a row September 4, 2014 Robinson Memorial Hospital again has been named as one of the best 99 places to work in Northeast Ohio by the Employers Resource Council. Osteoporosis event to celebrate healthy aging month September 4, 2014 During Robinson Memorial Hospital’s celebration of healthy aging month, there will be a program on Osteoporosis on Wednesday, September 10 from 6 ... Foundation Awards Student Scholarships July 10, 2014 The Robinson Memorial Hospital Foundation is pleased to announce the award of seven scholarships to children of Robinson Memorial Hospital and Robi... Robinson Wound Care Center Joins Healogics, Inc. to Raise Awareness of Chronic Wounds May 29, 2014 The Robinson Wound Care Center at ...
http://robinsonmemorial.org/main/news-releases/fuchs_appointed_as_general_counsel_16.aspx
*  Robinson News | News | News Releases | Robinson Memorial Hospital
-Any- Foundation News Robinson News. Foundation Awards Scholarships Benefitting Employees September 25, 2014 The Robinson Memorial Hospital Foundation is pleased to announce the awarding of 9 scholarships to employees of Robinson Memorial Hospital and Rob... Robinson wins NorthCoast 99 Award 12 years in a row September 4, 2014 Robinson Memorial Hospital again has been named as one of the best 99 places to work in Northeast Ohio by the Employers Resource Council. Osteoporosis event to celebrate healthy aging month September 4, 2014 During Robinson Memorial Hospital’s celebration of healthy aging month, there will be a program on Osteoporosis on Wednesday, September 10 from 6 ... Foundation Awards Student Scholarships July 10, 2014 The Robinson Memorial Hospital Foundation is pleased to announce the award of seven scholarships to children of Robinson Memorial Hospital and Robi... Robinson Wound Care Center Joins Healogics, Inc. to Raise Awareness of Chronic Wounds May 29, 2014 The Robinson Wound Care Center at ...
http://robinsonmemorial.org/main/news-releases/robinson_memorial_presents_poster_at_the_apic_annu_494.aspx?email=1
*  Robinson Health Center at Aurora | Robinson Memorial Hospital
robinson health center at aurora robinson memorial hospital about us foundation volunteer speaker s bureau press room contact us patients visitors medical services nursing find a doctor locations careers patient portal home locations robinson health center at aurora robinson health center at aurora walden place aurora ohio the robinson health center at aurora offers expert physicians personalized care and the latest in medical technology in one convenient location services and physician practices aurora primary care diagnostic x ray and laboratory services northeast ohio ob gyn robinson rehab center and sport clinic directions view larger map your name your email recipient email your comments word verification visitors patient portal key phone numbers visiting hours wheelchair assistance wi fi at robinson memorial hospital locations robinson memorial hospital robinson medical arts building robinson professional center robinson health center at aurora robinson health center at brimfield robinson health center ...
http://robinsonmemorial.org/Main/Aurora.aspx?email=1
*  Home | Robinson Memorial Hospital
Robinson Memorial Hospital. ABOUT US FOUNDATION VOLUNTEER SPEAKER'S BUREAU PRESS ROOM CONTACT US. Patients Visitors. Medical Services. Nursing. Find a Doctor. Locations. Careers. Patient Portal. Classes Events. Holiday Journeys - Grief Support. Mon, Oct 5, 2015. 2:00 PM - 4:00 PM. Holiday Journeys - Grief Support. Mon, Oct 5, 2015. 6:30 PM - 8:30 PM. Ostomy Support Group. Mon, Oct 5, 2015. 7:00 PM - 9:00 PM. Diabetes Support Group. Tue, Oct 6, 2015. 5:00 PM - 6:00 PM. Tue, Oct 6, 2015. 5:00 PM - 6:30 PM. Robinson In The News Robinson Memorial Hospital is now UH Portage Medical Center. Robinson Health System becomes part of University Hospitals on June 1. Robinson Memorial hosts 21st Annual Nursing Research Day. Robinson Memorial Hospital Foundation Hosts 2015 Robinson Society and Heritage Society Distinguished Giving Recognition. Doctors Receiving Top Scores in Patient Satisfaction Congratulations to the following doctors who rank in the 90th percentile on the Press Ganey Patient Satisfaction Survey. Jessica ...
http://robinsonmemorial.org/Main/Home.aspx
*  Rehabilitation | Robinson Memorial Hospital
Rehabilitation. Robinson Memorial Hospital. ABOUT US FOUNDATION VOLUNTEER SPEAKER'S BUREAU PRESS ROOM CONTACT US. Patients Visitors. Medical Services. Locations. Patient Portal. Medical Services. Rehabilitation. Rehabilitation. The Robinson Rehab Center and Sport Clinic works to rehabilitate each patient to his or her maximum potential and works to provide the patient with the necessary skills to maintain his or her progress. Ongoing communication between the patient, therapist and referring physician is the foundation of the center's rehabilitation programs. View Aquatic Classes. Team of Professionals Each therapist strives to stay on top of the latest technology and treatments and passes this knowledge along to patients. All Robinson Rehab Center and Sport Clinic professionals are licensed or certified by the State of Ohio. The center provides:. Aquatic aerobics, aquatic exercise and water arthritis classes in Ravenna. Locations: Robinson Medical Arts Building. 6847 North Chestnut Street Ravenna, Ohio 44266...
http://robinsonmemorial.org/main/rehabilitation.aspx
*  Shamim Patel - UK address and phone number - 192.com
... People. All People Businesses Places Electoral Roll Directors. Make sure the biggest decision you'll make is also the best. People. AZ-People. Surname - Patel. Your results for Shamim Patel. Filter Search. Search by name and/or location using the search form at the top of the page. Get access to likely ages Find old friends and family Double check names of spouses and children Trace your family tree Find out who your neighbours are Verify people are who they say they are. Make sure the biggest decision you'll make is also the best. Find out more. previous. 110 Results for Shamim Patel. Looking for Shamim Patel. Below are the results from the UK Electoral Roll and Company Director data. You can narrow your search by adding a location above if you wish. Name Address Other Occupants Electoral Roll Director Info Length of Occupancy Neighbours Property Price. 1 Shamim Patel. Age Guide: 40-44. Reading, Berkshire, RG2 Full Address. View. 2 Shamim R Patel. Age Guide: 30-34. Leicester, Leicestershire, LE5 Full Ad...
http://192.com/atoz/people/patel/shamim/
*  Phillip Phillips News, Pictures, and Videos | TMZ.com
Home Celebs Phillip Phillips Phillip Phillips. Idol Managers Claim John Mayer's ex-manager plotted to jack "American Idol" champ Phillip Phillips out from under his contract with the show -- according to a new lawsuit, but the bigger news is Phil is a READ MORE > - 9/21/2015 2:51 PM PDT. Phillip Phillips I Want to be Gone, Gone, Gone From My Idol Contract Phillip Phillips says "American Idol" producers are ruining his career ... American Idol Winner Phillip Phillips Mother Popped for DUI Phillip Phillips' mother Sheryl Phillips -- who appeared on several episodes of "American Idol" during Phillip's championship run last season -- was arrested for DUI earlier today, TMZ has READ MORE > - 964 days ago. Phillip Phillips I LOVE MY FAMILY But ... READ MORE > - 1064 days ago. Phillip Phillips Family Idol Champ s Forcing Us To Sell Pawn Shop Phillip Phillips' family says the singer left them high and dry after winning "American Idol" -- refusing to help them out financially -- and now, they've been forced to sell th...
http://tmz.com/person/phillip-phillips/?adid=cr_featured_saga_13
*  Shadowing | Robinson Memorial Hospital
Shadowing. Robinson Memorial Hospital. ABOUT US FOUNDATION VOLUNTEER SPEAKER'S BUREAU PRESS ROOM CONTACT US. Patients Visitors. Medical Services. Nursing. Find a Doctor. Locations. Careers. Patient Portal. Home. Volunteer. Shadowing. Shadowing. Robinson Memorial Hospital offers several types of opportunities for short-term observational learning experiences for high school, college and adult students pursuing healthcare careers. The process to apply for a shadow experience depends on the age of the applicant. Note: Robinson Memorial Hospital has a mandatory flu vaccination policy for all employees, volunteers, contracted workers and shadow students. Students wanting to shadow at Robinson Memorial must provide proof of receiving a flu vaccine during current flu season - either by a receipt showing the student's name and detail of service from the provider, an insurance benefits explanation or detailed note from a physician. Students can bring their vaccine documentation the morning of their assigned shadow exp...
http://robinsonmemorial.org/Main/Shadowing.aspx
*  [Haskell-cafe] System.Random.Shuffle fix
System.Random.Shuffle fix. System.Random.Shuffle fix friggin friggin frigginfriggins at gmail.com. Previous message: A small display problem using Helium Next message: System.Random.Shuffle fix Messages sorted by:. I was looking for a shuffling algorithm to shuffle mp3-playlists so was very happy to see System.Random.Shuffle: http://hackage.haskell.org/cgi-bin/hackage-scripts/package/random-shuffle-0.0.2 However I get errors,non-exhaustive patterns in function shufleTree or extractTree depending how I call it. Errors are at the bottom. I fixed it but I don't have the math skills to see if I perhaps broke it statistically ... Here is my fix, someone don't remember who, helped me a little : http://hpaste.org/fastcgi/hpaste.fcgi/view?id=2789#a2789 the shuffle at the end is with the fix. *Freet S.shuffle Loading package syb ... linking ... Loading package base-3.0.3.0 ... linking ... Loading package old-locale-1.0.0.1 ... linking ... Loading package old-time-1.0.0.1 ... linking ... Loading package random-1.0.0.1 ...
https://mail.haskell.org/pipermail/haskell-cafe/2009-March/058399.html
*  OriGene - LRRC2 (NM 024512) cDNA Clone
OriGene - LRRC2 NM 024512 cDNA Clone. cDNA Clones TrueORF cDNA Clones H/M/R Viral ORF Clones Destination Vector TrueClone Human TrueClone Mouse Organelle Marker Plasmids MicroRNA Tools Mutant and Variant Clones Plasmid Purification Kits Transfection Reagents Gene Synthesis Service. Home TrueClone LRRC2 Clone. LRRC2 NM 024512 Human cDNA Clone. SC310473 LRRC2 untagged -Human leucine rich repeat containing 2 LRRC2, NM 024512.2, 10ug $680 3 weeks. Reference Data RefSeq: NM 024512.2, NP 078788. Synonyms : leucine-rich repeat-containing 2; leucine rich repeat containing 2. More TrueClone Citations >>. LRRC2 Mouse Clones SKU Description Amount Price Shipping. MC211501 Lrrc2 untagged - Mouse leucine rich repeat containing 2 Lrrc2, 10ug 10 ug $380 3 weeks. MR216368 Lrrc2 Myc-DDK-tagged - Mouse leucine rich repeat containing 2 Lrrc2 10 ug $380 Next day. MG216368 Lrrc2 GFP-tagged - Mouse leucine rich repeat containing 2 Lrrc2, 10ug 10 ug $420 3 weeks. MR216368L1 Lenti ORF clone of Lrrc2 Myc-DDK-tagged - Mouse leucine ri...
http://origene.com/cdna/trueclone/accession/NM_024512/SC310473.aspx
*  JUST LIKE A WOMAN LYRICS - BOB DYLAN
just like a woman lyrics bob dylan sing lyrics bob dylan biography bob dylan albums bob dylan lyrics bob dylan just like a woman lyrics last updated pm sponsored links nobody feels any pain tonight as i stand inside the rain ev rybody knows that baby s got new clothes but lately i see her ribbons and her bows have fallen from her curls she takes just like a woman yes she does she makes love just like a woman yes she does and she aches just like a woman but she breaks just like a little girl queen mary she s my friend yes i believe i ll go see her again nobody has to guess that baby can t be blessed till she finally sees that she s like all the rest with her fog her amphetamine and her pearls she takes just like a woman yes she does she makes love just like a woman yes she does and she aches just like a woman but she breaks just like a little girl it s was raining from the first and i was dying there of thirst so i came in here and your long time curse hurts but what s worse is this pain in here i can t stay i...
http://sing365.com/music/Lyric.nsf/Just-Like-A-Woman-lyrics-Bob-Dylan/659E935998737E48482569690029ABC7
*  Gary Phillips eBooks | epub and pdf downloads | eBookMall
Gary Phillips eBooks. epub and pdf downloads. eBookMall. Search. Sponsored link: What is YOUR Secret Talent. - Take a Free Personality test. Gary Phillips eBooks Epub and PDF format. Gary Phillips eBooks. eBooks found: 15 Occupied Earth: Stories of Aliens, Resistance and Survival at all Costs. Richard Brewer. Gary Phillips Polis Books, October 2015. ISBN: 9781940610528 Format: ePub. List Price: $ 9.99 Our price: $ 7.99. Violent Spring. Gary Phillips mysteriouspress.com, June 2014. ISBN: 9781784087968 Format: ePub. List Price: $ 13.11 Our price: $ 9.99. Perdition, U.S.A. Gary Phillips mysteriouspress.com, June 2014. ISBN: 9781784087975 Format: ePub. List Price: $ 13.11 Our price: $ 9.99. Bad Night Is Falling. Gary Phillips mysteriouspress.com, June 2014. ISBN: 9781784087982 Format: ePub. List Price: $ 13.11 Our price: $ 9.99. Only the Wicked. Gary Phillips mysteriouspress.com, June 2014. ISBN: 9781784087951 Format: ePub. List Price: $ 13.11 Our price: $ 9.99. The Extractors. Gary Phillips Stark Raving Group, M...
http://ebookmall.com/author/gary-phillips
*  "Beyond Stroke" Support Group | Events | Calendar of Events | Robinson Memorial Hospital
beyond stroke support group events calendar of events robinson memorial hospital about us foundation volunteer speaker s bureau press room contact us patients visitors medical services nursing find a doctor locations careers patient portal beyond stroke support group calendar view back to previous page support groups tuesday october pm pm description stroke survivors and caregivers will benefit from information presented by a variety of speakers as well as from sharing and support of their peers for information call jan bahle at location robinson medical arts building rmab n chestnut st ravenna ohio contact healtheducation rmh org phone visitors patient portal key phone numbers visiting hours wheelchair assistance wi fi at robinson memorial hospital locations robinson memorial hospital robinson medical arts building robinson professional center robinson health center at aurora robinson hea...
http://robinsonmemorial.org/Main/Calendar/659.aspx
*  Deposition of Bobby Phillips States That Erwin Cain Sold Cocaine
... Home About Stories. Featured. BOR Featured. User Stories. Deposition of Bobby Phillips States That Erwin Cain Sold Cocaine. Deposition of Bobby Phillips States That Erwin Cain Sold Cocaine 3. By Burnt Orange Report. on October 19, 2010. Bobby Phillips, Jr. Phillips states that he met Erwin Cain in October of 1977, when he was engaged to Erwin's sister, Gloria Cain. Attorney : Did you ever see Mr. Erwin Cain sell drugs. Phillips : Yeah, I've seen him deliver to his brother-in-law, to his brother, and to other people that came by the house when he was there. Attorney : Do you know where Thomas Cain, Jr. Attorney: which brother would that be. Phillips : Erwin. Attorney: Just to clarify, and let me repeat it's your statement that you have seen, in the past, a man you can identify as Erwin Cain use marijuana. Phillips : Yes. Attorney: Have you, and is it your statement also that you have seen him sell marijuana to someone. Phillips : Yeah. Phillips : It was usually just we used to go over to his h...
http://burntorangereport.com/diary/10880/deposition-of-bobby-phillips-states-that-erwin-cain-sold-cocaine
*  Anthony Robinson | dafont.com
Anthony Robinson. dafont.com. English. Fran ais. Espa ol. Deutsch. Italiano. Portugu s Login. Register. Themes New fonts Authors Top Forum FAQ Submit a font Tools. 4 matching requests on the forum Anthony Robinson 1. 2 3. Anthony Robinson. View profile Send a private message http://www.redbubble.com/people/anfa/portfolio 58 fonts - 4,331,510 downloads 2,129 yesterday. Preview. Fonts 10 20 50 100. Show variants. Size Tiny Small Medium Large Sort by Name Popularity Newer first. More options. Only as. Public domain / GPL / OFL. 100% Free. Free for personal use. Donationware. Shareware. Demo. Unknown Only fonts with. Accents. Euro. Newcastle by Anthony Robinson. in Fancy. Decorative 15,200 downloads 4 yesterday. 100% Free - 2 font files Download Donate to author. Static Buzz by Anthony Robinson. in Fancy. Distorted 104,264 downloads 4 yesterday. 100% Free Download Donate to author. Lasso Of Truth by Anthony Robinson. in Gothic. Modern 5,855 downloads 4 yesterday. 100% Free Download Donate to author. Punched by An...
http://dafont.com/anthony-robinson.d2796?page=3
*  Anthony Robinson | dafont.com
Anthony Robinson. dafont.com. English. Fran ais. Espa ol. Deutsch. Italiano. Portugu s Login. Register. Themes New fonts Authors Top Forum FAQ Submit a font Tools. 4 matching requests on the forum Anthony Robinson 1. 2 3. Anthony Robinson. View profile Send a private message http://www.redbubble.com/people/anfa/portfolio 58 fonts - 4,333,980 downloads 2,470 yesterday. Preview. Fonts 10 20 50 100. Show variants. Size Tiny Small Medium Large Sort by Name Popularity Newer first Reinitialize More options. Only as. Public domain / GPL / OFL. 100% Free. Free for personal use. Donationware. Shareware. Demo. Unknown Only fonts with. Accents. Euro. First by Anthony Robinson. in Techno. Sci-fi 12,112 downloads 3 yesterday. 100% Free Download Donate to author. Newcastle by Anthony Robinson. in Fancy. Decorative 15,203 downloads 3 yesterday. 100% Free - 2 font files Download Donate to author. New York Punk by Anthony Robinson. in Fancy. Destroy 20,765 downloads 3 yesterday. 100% Free Download Donate to author. Lasso Of T...
http://dafont.com/anthony-robinson.d2796?page=5&text=AUBURN
*  Phillip Phillips Ringtones Free Download - Ringtone Maker Audiko
... Sublime, Kendrick Lamar, DevilDriver, K. Michelle, Five Finger Death Punch. Mobile apps. Login. JavaScript must be enabled in order for you to use Audiko in standard view. A B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S. T. U. V. W. X. Y. Z. 0...9. Thousands of ringtones on Audiko.net. Here is a chance to download a free Phillip Phillips ringtones for your iPhone or mobile. Specify your favorite line from your favorite award-winning track - Beggin, Get Up Get Down, Unpack Your Heart, or any other track. You may download your ringtone both in the MP3 and m4a formats, supported by both mobile phones and iPhones. Just select a track, and choose free Phillip Phillips ringtones download option. Download Phillip Phillips Ringtones. Top free ringtones. Name. Gone, Gone, Gone. Home. Raging Fire. Alive Again. Face. Get Up Get Down. Searchlight. Volcano. U Got It Bad. We've Got Tonight. Albums. Behind the Light Deluxe Version. Phillip Phillips. Weve Got Tonight American Idol Performance Single. Phillip Phil...
http://audiko.net/ringtone/phillip-phillips
*  Coles Phillips
... 'Clarence Coles Phillips' October 1880June 13, 1927 was an American artist and illustrator who signed his early works 'C. Coles Phillips', but after 1911 worked under the abbreviated name, 'Coles Phillips'. He is known for his stylish images of women and a signature use of negative space in the paintings he created for advertisements and the covers of popular magazines. Early life Career Personal life Notes References External links. Early life. ' ' Michael Schau, Watson-Guptill, 1975, p. Image:Coles Phillips2 Life.jpg The work of Phillips quickly became popular with the 'Life' readers. Schau & Phillips 1975, p. Phillips' use of negative space allowed the viewer to "fill-in" the image; it also reduced printing costs for the magazine, as "the novelty of the technique and the striking design qualities masked the fact that 'Life' was getting by with single color or two-color covers in a day when full-color covers were de rigueur for the better magazines". Phillips worked in watercolor and always painted fro...
https://en.wikipedia.org/wiki/Coles_Phillips
*  Phillip Phillips News, Pictures, and Videos | TMZ.com
Idol Managers Claim John Mayer's ex-manager plotted to jack "American Idol" champ Phillip Phillips out from under his contract with the show -- according to a new lawsuit, but the bigger news is Phil is a READ MORE > - 9/21/2015 2:51 PM PDT. Phillip Phillips I Want to be Gone, Gone, Gone From My Idol Contract Phillip Phillips says "American Idol" producers are ruining his career ... American Idol Winner Phillip Phillips Mother Popped for DUI Phillip Phillips' mother Sheryl Phillips -- who appeared on several episodes of "American Idol" during Phillip's championship run last season -- was arrested for DUI earlier today, TMZ has READ MORE > - 963 days ago. READ MORE > - 1063 days ago. Phillip Phillips Family Idol Champ s Forcing Us To Sell Pawn Shop Phillip Phillips' family says the singer left them high and dry after winning "American Idol" -- refusing to help them out financially -- and now, they've been forced to sell their cherished READ MORE > - 1066 days ago. Phillip Phillips Crooks Smash In Pawn Shop, St...
http://tmz.com/person/phillip-phillips/?adid=cr_featured_saga_14
*  HERBICIDE-TOLERANT PLANTS - BASF AGROCHEMICAL PRODUCTS.B.V.
In addition, enzymes of this embodiment will also comprise one or more of a leucine, threonine, a valine, or alanine at position 1,781 Am, a glycine at position l,785 Am, a proline at position l,786 Am, an asparagine at position 1,811 Am, a proline at position l,824 Am, a cysteine or glycine at position l,999 Am, a cysteine or arginine at position 2,027 ' Am, a glycine at position 2,039 Am, an asparagine at position 2,041 Am, a phenylalanine, isoleucine or leucine at position 2,049 Am, a valine at position 2,059 Am, a leucine at position 2,074 Am, a leucine, isoleucine, methionine or additional valine at position 2,075 Am, a glycine or threonine at position 2,078 Am, a phenylalanine at position 2,079 Am, a glutamic acid at position 2,080 Am, a deletion at position 2,080 Am, a deletion at position 2,081 Am, an arginine, tryptophan, phenylalanine, glycine, histidine, lysine, leucine, serine, threonine, or valine at position 2,088 Am, a glutamic acid at position 2,095 Am, an alanine or serine at position 2,096 A...
http://sumobrain.com/patents/wipo/Herbicide-tolerant-plants/WO2011028836.html
*  Bimolecular fluorescence complementation
This was achieved by dissecting GFP into C- and N-terminal GFP fragments. In addition, this study was the first report of an ' in vivo ' technique, now known as the bimolecular fluorescence complementation BiFC assay, to provide insight into the structural basis of protein complex formation through detection of fluorescence caused by the assembly of fluorescent reporter protein fragments tethered to interacting proteins. Generally, YFP is recommended to serve as the reporter protein, cleaved at residue 155 N-terminal consisting of residues 1–154 and C-terminal consisting of residues 155–238 or residue 173 in particular, as these sets of fragments are highly efficient in their complementation when fused to many interacting proteins and they produce low levels fluorescence when fused to non-interacting proteins. It is suggested that each target protein is fused to both the N- and C-terminal fragments of the fluorescent reporter protein in turn, and that the fragments are fused at each of the N- and C-terminal e...
https://en.wikipedia.org/wiki/Bimolecular_fluorescence_complementation
*  Candice Olson Family Spaces ISBN 9781118276679 PDF epub | Candice Olson ebook | eBookMall
Candice Olson Family Spaces ISBN 9781118276679 PDF epub. Candice Olson ebook. eBookMall. Candice Olson Family Spaces. Candice Olson. Design : Interior Decorating. Digital Book format: ePub Adobe DRM. Buy ePub. List price: $ 19.99 Our price: $ 16.99. Popular TV star Candice Olson shows you how to create your dream family room Everybody wants their home's main living space to meet the needs of the whole family—and look great doing it. Chock full of tips and ideas, Candice Olson Family Spaces features hundreds of full-color, before-and-after photos of Candice's stunning family room makeovers. Explains how good design accommodates all members of the family and their daily activities Designs offer functionality, durability, and comfort without sacrificing style As a busy mother of two, Candice brings valuable insight to what a family really needs from the spaces they share Redecorating—or even just dreaming about decorating—can transform one's outlook on life, and Candice Olson Family Spaces is the catalyst to get...
http://ebookmall.com/ebook/candice-olson-family-spaces/candice-olson/9781118276679
*  Abner Phillips (1737-1813), p.2
Abner Phillips - Surry County, NC There were Phillips in Surry County, NC as early as 1771, according to tax lists. Lewis' Dist.: Abner PHILLIPS, 400 acres, 1 white poll. LEWIS to Abner PHILLIPS, 300 acres on north side of Yadkin River, east side Turkey Creek, for 75. LEWIS to Abner PHILLIPS, 100 acres on north side of Yadkin River at Turkey Creek, for 75. Phillips Dist.: Abner PHILLIPS, 400 acres, 2 white polls. 1790 Census, Surry Co., NC, p.186: ABNER PHILLIPS 3 white males under 16 2 white males over 16 3 white females no slaves Note: Abner's sons Cornelius PHILLIPS and Ephraim PHILLIPS are also listed in the 1790 Census of Surry Co., NC, p.183. 1800 Census, Surry Co., NC: ABNER PHILLIPS. 1810 Census, Surry Co., NC, p.193: ABNER PHILLIPS. In the name of God Amen this tenth day of November in year of our lord 1812 I ABNER PHILLIPS of Surry County State of North Carolina being sick and weak in Body but in perfect mind memory thanks be given to God For the Same Calling unto mind the mortality of my bo...
http://moonzstuff.com/phillips/abner1737_p2.html
*  "Dear Abby" Advice Columnist Pauline Phillips Dead at 94 - Us Weekly
... US Weekly. News. Photos. Style. Beauty. Moms. Body. Entertainment. Subscribe. Give a Gift. Us Weekly. Newsletter. Subscribe. ADVERTISEMENT. "Dear Abby" Advice Columnist Pauline Phillips Dead at 94. Celebrity News. Jan. Tweet. Columnist Abigail Van Buren attends Friends Of Mario Cuomo Fundraiser Dinner on November 30, 1989 at the Sheraton Center in New York City. Newspapers -- and readers -- the world over lost an icon Wednesday, Jan. 16, after "Dear Abby" advice columnist Pauline Phillips died in Minneapolis at the age of 94. Phillips had suffered from Alzheimer's disease for years, but was still dishing out advice to readers as recently as 2002, though her daughter Jeanne took on co-authoring duties in the mid-1990s. PHOTOS: Stars we lost in 2012. Phillips, who wrote under the pen name Abigail Van Buren, shared advice on everything from dating to snoring spouses for more than 40 years to a readership of more than 90 million newspaper readers. "They gave her a bunch of letters, thinking that they would n...
http://usmagazine.com/celebrity-news/news/dear-abby-advice-columnist-pauline-phillips-dead-at-94-2013171
*  Joanna Phillips | UCSF Medical Center
Joanna Phillips. UCSF Medical Center. About UCSF. Find a Doctor. Conditions Treatments. Conditions Treatments A-Z. Patient Education. Doctors. Find a Doctor. Getting to UCSF Medical Center. Careers at UCSF Medical Center. UCSF Medical Group. Home > Doctors > Joanna Phillips. Find a Doctor. Joanna Phillips, M.D. Joanna Phillips is a neuropathologist at UCSF Medical Center who helps diagnose neurologic disease through the examination of central nervous system tissue. As an academic neuropathologist, her goal is to improve the treatment of brain tumors through research and patient care. She completed a pathology residency at the University of Washington in Seattle, followed by a fellowship in neuropathology at UCSF. Phillips is a member of several professional organizations, including the American Society for Investigative Pathology, American Association of Neuropathologists, American Association for Cancer Research and Glycobiology Research and Training Program. Safaee M, Fakurnejad S, Bloch O, Clark AJ, Ivan M...
http://ucsfhealth.org/joanna.phillips
*  SMART: Secondary literature for GLUCA domain
smart secondary literature for gluca domain smart mode normal genomic schultz et al proc natl acad sci usa letunic et al nucleic acids res doi nar gku home setup faq about glossary what s new feedback secondary literature sources for gluca the following references were automatically generated lopez lc frazier ml su cj kumar a saunders gf mammalian pancreatic preproglucagon contains three glucagon related peptides proc natl acad sci u s a display abstract we have isolated cdna clones encoding bovine pancreatic preproglucagon twenty five putative preproglucagon clones were selected by screening clones of a fetal bovine pancreas cdna library with a synthetic oligodeoxynucleotide probe the probe was a mixture of synthetic base dna oligomers constructed to correspond to the six carboxyl terminal amino acids residues of mature glucagon restriction mapping of six of these clones suggested that they represented a single mrna species primary sequence analysis of one clone containing a base pair dna insert revealed tha...
http://smart.embl-heidelberg.de/smart/show_secondary.cgi?domain=GLUCA

Assay sensitivity: Assay sensitivity is a property of a clinical trial defined as the ability of a trial to distinguish an effective treatment from a less effective or ineffective intervention. Without assay sensitivity, a trial is not internally valid and is not capable of comparing the efficacy of two interventions.Specificity constant: In the field of biochemistry, the specificity constant (also called kinetic efficiency or k_{cat}/K_{M}), is a measure of how efficiently an enzyme converts substrates into products. A comparison of specificity constants can also be used as a measure of the preference of an enzyme for different substrates (i.Coles PhillipsProtein primary structure: The primary structure of a peptide or protein is the linear sequence of its amino acid structural units, and partly comprises its overall biomolecular structure. By convention, the primary structure of a protein is reported starting from the amino-terminal (N) end to the carboxyl-terminal (C) end.Generalizability theory: Generalizability theory, or G Theory, is a statistical framework for conceptualizing, investigating, and designing reliable observations. It is used to determine the reliability (i.Symmetry element: A symmetry element is a point of reference about which symmetry operations can take place. In particular, symmetry elements can be centers of inversion, axes of rotation and mirror planes.Burst kinetics: Burst kinetics is a form of enzyme kinetics that refers to an initial high velocity of enzymatic turnover when adding enzyme to substrate. This initial period of high velocity product formation is referred to as the "Burst Phase".DNA binding site: DNA binding sites are a type of binding site found in DNA where other molecules may bind. DNA binding sites are distinct from other binding sites in that (1) they are part of a DNA sequence (e.Silent mutation: Silent mutations are mutations in DNA that do not significantly alter the phenotype of the organism in which they occur. Silent mutations can occur in non-coding regions (outside of genes or within introns), or they may occur within exons.Thermal cyclerBioline Reagents: Bioline Reagents is a primary manufacturer and developerBioline: The PCR Company | Company Profile of a wide range of specialised molecular biology products for the life science industry and research markets. It manufactures reagents including ultra-pure nucleotides, DNA polymerases and mixes, DNA markers, competent cells, products for RNA analysis and other general reagents for molecular biology.Temporal analysis of products: Temporal Analysis of Products (TAP), (TAP-2), (TAP-3) is an experimental technique for studyingProximity ligation assay: Proximity ligation assay (in situ PLA) is a technology that extends the capabilities of traditional immunoassays to include direct detection of proteins, protein interactions and modifications with high specificity and sensitivity. Protein targets can be readily detected and localized with single molecule resolution and objectively quantified in unmodified cells and tissues.Eva Engvall: Eva Engvall, born 1940, is one of the scientists who invented ELISA in 1971.Eva Engvall, The Scientist 1995, 9(18):8Reaction coordinatePrevalence: Prevalence in epidemiology is the proportion of a population found to have a condition (typically a disease or a risk factor such as smoking or seat-belt use). It is arrived at by comparing the number of people found to have the condition with the total number of people studied, and is usually expressed as a fraction, as a percentage or as the number of cases per 10,000 or 100,000 people.List of strains of Escherichia coli: Escherichia coli is a well studied bacterium that was first identified by Theodor Escherich, after whom it was later named.FERM domain: In molecular biology, the FERM domain (F for 4.1 protein, E for ezrin, R for radixin and M for moesin) is a widespread protein module involved in localising proteins to the plasma membrane.Immunoassay: An immunoassay is a biochemical test that measures the presence or concentration of a macromolecule in a solution through the use of an antibody or immunoglobulin. The macromolecule detected by the immunoassay is often referred to as an "analyte" and is in many cases a protein.Clonal Selection Algorithm: In artificial immune systems, Clonal selection algorithms are a class of algorithms inspired by the clonal selection theory of acquired immunity that explains how B and T lymphocytes improve their response to antigens over time called affinity maturation. These algorithms focus on the Darwinian attributes of the theory where selection is inspired by the affinity of antigen-antibody interactions, reproduction is inspired by cell division, and variation is inspired by somatic hypermutation.CS-BLASTDNA condensation: DNA condensation refers to the process of compacting DNA molecules in vitro or in vivo. Mechanistic details of DNA packing are essential for its functioning in the process of gene regulation in living systems.Ethyl groupLigation-independent cloning: Ligation-independent cloning (LIC) is a form of molecular cloning that is able to be performed without the use of restriction endonucleases or DNA ligase. This allows genes that have restriction sites to be cloned without worry of chopping up the insert.Ferric uptake regulator family: In molecular biology, the ferric uptake regulator (FUR) family of proteins includes metal ion uptake regulator proteins. These are responsible for controlling the intracellular concentration of iron in many bacteria.Monoclonal antibody therapyConcentration effect: In the study of inhaled anesthetics, the concentration effect is the increase in the rate that the Fa(alveolar concentration)/Fi(inspired concentration) ratio rises as the alveolar concentration of that gas is increased. In simple terms, the higher the concentration of gas administered, the faster the alveolar concentration of that gas approaches the inspired concentration.SEA Native Peptide LigationPamela Dalton: Dr. Pamela Dalton is a cognitive psychologist.Percolation threshold: Percolation threshold is a mathematical concept related to percolation theory, which is the formation of long-range connectivity in random systems. Below the threshold a giant connected component does not exist; while above it, there exists a giant component of the order of system size.Cryptic self epitopes: In immunology, cryptic self epitopes are a source of autoimmunity.Alkaliphile: Alkaliphiles are a class of extremophilic microbes capable of survival in alkaline (pH roughly 8.5-11) environments, growing optimally around a pH of 10.Replica plating: 350px|right|thumb|[[Negative selection (artificial selection)|Negative selection through replica plating to screen for ampicillin sensitive colonies]]Database of protein conformational diversity: The Database of protein conformational diversity (PCDB) is a database of diversity of protein tertiary structures within protein domains as determined by X-ray crystallography. Proteins are inherently flexible and this database collects information on this subject for use in molecular research.Insulin signal transduction pathway and regulation of blood glucose: The insulin transduction pathway is an important biochemical pathway beginning at the cellular level affecting homeostasis. This pathway is also influenced by fed versus fasting states, stress levels, and a variety of other hormones.Matrix model: == Mathematics and physics ==Beef cattle: Beef cattle are cattle raised for meat production (as distinguished from dairy cattle, used for milk production). The meat of adult cattle is known as beef.Permissive temperature: The permissive temperature is the temperature at which a temperature sensitive mutant gene product takes on a normal, functional phenotype.http://www.Biomarkers of aging: Biomarkers of aging are biomarkers that better predict functional capacity at a later age than chronological age. Stated another way, biomarkers of aging would give the true "biological age", which may be different from the chronological age.GeneXpert MTB/RIFNew Zealand rabbitCD4 immunoadhesin: CD4 immunoadhesin is a recombinant fusion protein consisting of a combination of CD4 and the fragment crystallizable region.Mature messenger RNA: Mature messenger RNA, often abbreviated as mature mRNA is a eukaryotic RNA transcript that has been spliced and processed and is ready for translation in the course of protein synthesis. Unlike the eukaryotic RNA immediately after transcription known as precursor messenger RNA, it consists exclusively of exons, with all introns removed.Calcium signaling: Calcium ions are important for cellular signalling, as once they enter the cytosol of the cytoplasm they exert allosteric regulatory effects on many enzymes and proteins. Calcium can act in signal transduction resulting from activation of ion channels or as a second messenger caused by indirect signal transduction pathways such as G protein-coupled receptors.DNA-binding proteinImmunoperoxidase: Immunoperoxidase is a type of immunostain used in molecular biology, medical research, and clinical diagnostics. In particular, immunoperoxidase reactions refer to a sub-class of immunohistochemical or immunocytochemical procedures in which the antibodies are visualized via a peroxidase-catalyzed reaction.Phenotype microarray: The phenotype microarray approach is a technology for high-throughput phenotyping of cells.Phase problem: In physics the phase problem is the name given to the problem of loss of information concerning the phase that can occur when making a physical measurement. The name itself comes from the field of x-ray crystallography, where the phase problem has to be solved for the determination of a structure from diffraction data.Cancer screeningRNA transfection: RNA transfection is the process of deliberately introducing RNA into a living cell. RNA can be purified from cells after lysis or synthesized from free nucleotides either chemically, or enzymatically using an RNA polymerase to transcribe a DNA template.Margaret Jope: Margaret Jope (1913–2004) was a Scottish biochemist, born as Henrietta Margaret Halliday in Peterhead, Scotland.DNA sequencer: A DNA sequencer is a scientific instrument used to automate the DNA sequencing process. Given a sample of DNA, a DNA sequencer is used to determine the order of the four bases: G (guanine), C (cytosine), A (adenine) and T (thymine).Pituitary-specific positive transcription factor 1: POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1), also known as POU1F1, is a transcription factor for growth hormone.WIN 56,098: WIN 56,098 is a chemical that is considered to be an aminoalkylindole derivative. It is a tricyclic aryl derivative that acts as a competitive antagonist at the CB2 cannabinoid receptor.HyperintensityZuotin: Z-DNA binding protein 1, also known as Zuotin, is a Saccharomyces cerevisiae yeast gene.Triparental mating: Triparental mating is a form of Bacterial conjugation where a conjugative plasmid present in one bacterial strain assists the transfer of a mobilizable plasmid present in a second bacterial strain into a third bacterial strain. Plasmids are introduced into bacteria for such purposes as transformation, cloning, or transposon mutagenesis.Ligand (biochemistry): In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose. In protein-ligand binding, the ligand is usually a signal-triggering molecule binding to a site on a target protein.Hyperphosphorylation: Hyperphosphorylation occurs when a biochemical with multiple phosphorylation sites is fully saturated. Hyperphosphorylation is one of the signalling mechanisms used by the cell to regulate mitosis.Liver sinusoid: A liver sinusoid is a type of sinusoidal blood vessel (with fenestrated, discontinuous endothelium) that serves as a location for the oxygen-rich blood from the hepatic artery and the nutrient-rich blood from the portal vein.SIU SOM Histology GICancer biomarkers: A cancer biomarker refers to a substance or process that is indicative of the presence of cancer in the body. A biomarker may be a molecule secreted by a tumor or a specific response of the body to the presence of cancer.Molar mass distribution: In linear polymers the individual polymer chains rarely have exactly the same degree of polymerization and molar mass, and there is always a distribution around an average value. The molar mass distribution (or molecular weight distribution) in a polymer describes the relationship between the number of moles of each polymer species (Ni) and the molar mass (Mi) of that species.

(1/50409) Analysis of gabapentin in serum and plasma by solid-phase extraction and gas chromatography-mass spectrometry for therapeutic drug monitoring.

A simple method for the determination of gabapentin (Neurontin) is described. The method uses solid-phase extraction by disk column and derivatization followed by gas chromatographic-mass spectrometric analysis. The single-step derivatization with MTBSTFA produces a t-BDMS derivative of both the carboxylic and amine moieties of the molecule. Each step of the procedure was optimized to assure reliable performance of the method. The assay limit of detection was 0.1 microg/mL with a linear range from 1.0 to 35 microg/mL. Within-run (n = 3) and between-run (n = 40) coefficients of variation were less than 8.2 and 15.9%, respectively. The method has proven reliable in routine production for more than a year, producing clean chromatography with unique ion fragments, consistent ion mass ratios, and no interferences. Statistical analysis of the gabapentin concentrations measured in 1020 random specimens over a 2-month period showed a mean concentration of 6.07 microg/mL with a standard deviation of 5.28.  (+info)

(2/50409) Solid-phase microextraction for cannabinoids analysis in hair and its possible application to other drugs.

This paper describes the application of solid-phase microextraction (SPME) to cannabis testing in hair. Fifty milligrams of hair was washed with petroleum ether, hydrolyzed with NaOH, neutralized, deuterated internal standard was added and directly submitted to SPME. The SPME was analyzed by GC-MS. The limit of detection was 0.1 ng/mg for cannabinol (CBN) and delta9-tetrahydrocannabinol (THC) and 0.2 ng/mg for cannabidiol (CBD). THC was detected in a range spanning from 0.1 to 0.7 ng/mg. CBD concentrations ranged from 0.7 to 14.1 ng/mg, and CBN concentrations ranged from 0.4 to 0.7 ng/mg. The effectiveness of different decontamination procedures was also studied on passively contaminated hair. The proposed method is also suitable for the analysis of methadone in hair; cocaine and cocaethylene can be detected in hair with SPME extraction after enzymatic hydrolysis.  (+info)

(3/50409) Highly sensitive quantitation of methamphetamine by time-resolved fluoroimmunoassay using a new europium chelate as a label.

A simple and highly sensitive time-resolved fluoroimmunoassay of methamphetamine (MA) using a new fluorescent europium chelate (BHHCT-Eu3+) as a label is described. Two variations of competitive immunoassay were attempted. In the first (one-step) assay, microtiter plates coated with anti-MA were used, and the new label was bound to a conjugate of bovine serum albumin and N-(4-aminobutyl)-MA (MA-BSA). In the second (two-step) assay, instead of the labeled MA-BSA, biotinylated MA-BSA and BHHCT-Eu3+-labeled streptavidin-BSA were used. The lowest measurable concentrations of MA for the one-step and the two-step methods were 1 ng/mL (25 pg/assay) and 1 pg/mL (25 fg/assay), respectively. These were 10 to 1000 times superior to the detection limits of MA in any other immunoassay. Intra-assay coefficient of variation was approximately 2-8% at eight different concentrations (n = 4). Analysis of 34 urine samples with the new method and conventional gas chromatography showed a good correlation (r = 0.954). The high detectability of the present assay also enabled segmental hair analysis with a few centimeters of a hair.  (+info)

(4/50409) Semiautomated preparation of 3,5,6-trichloro-2-pyridinol in human urine using a Zymate XP laboratory robot with quantitative determination by gas chromatography-negative-ion chemical ionization mass spectrometry.

A rapid and sensitive semiautomated method was developed for quantitation of the chlorpyrifos metabolite 3,5,6-trichloro-2-pyridinol (TCP) in human urine. A Zymark Zymate XP laboratory robotics system was used to mix urine samples, transfer aliquots, add the stable-isotope-labeled TCP internal standard (13C2- or 13C2,15N-), and liberate conjugates of TCP from urine via acid hydrolysis. Samples were manually extracted into toluene, derivatized, and analyzed by gas chromatography-negative-ion chemical ionization mass spectrometry. Determination of the metabolic TCP was performed by selected ion monitoring of the dichloropyridinol fragment ions: m/z 161 for TCP and m/z 165 for 13C2-TCP or m/z 168 for 13C2,15N-TCP. Interday precision and accuracy were demonstrated over 3 years of analyses using the 13C2-TCP internal standard, with an average recovery from fortified urine samples of 93+/-12% (N = 54, concentration range 1-140 ng/mL). The method was found to be linear over the range of 0.5 to 200 ng/mL, and the limit of detection for TCP in urine was estimated to be 0.2 ng/mL with a limit of quantitation of 1 ng/mL. The effect of solids distribution on the concentration of TCP in the thawed urine samples was examined, and the results indicated that homogeneous distribution is critical for quantitation. The precision and accuracy of the automated method with respect to the transfer of homgeneous urine aliquots and delivery of internal standard yielded equivalent or improved results over the manual techniques. Overall, this method is more simple than existing methodologies, and it yields results with improved precision, accuracy, and sensitivity over previously developed methods.  (+info)

(5/50409) Identification and quantification of cocaine N-oxide: a thermally labile metabolite of cocaine.

In this article, we report the identification and quantitation of cocaine N-oxide (CNO), a thermally labile oxidative metabolite, from both animal and human samples. The concentration of CNO is similar to the concentrations of cocaine in the samples analyzed. The technique used for the determination of CNO in this study is liquid chromatography-electrospray ionization mass spectrometry, which is necessary because CNO is converted to cocaine upon heating. This includes simple heating of aqueous solutions to temperatures in excess of 100 degrees C and analysis by gas chromatography-mass spectrometry (GC-MS), in which CNO is converted to cocaine in the injection port. The thermal conversion of CNO to cocaine is estimated to cause an over-reporting of cocaine levels by 10-20% when using GC-MS.  (+info)

(6/50409) Hybrid capture II, a new sensitive test for human papillomavirus detection. Comparison with hybrid capture I and PCR results in cervical lesions.

AIM: To test a new assay for the detection of human papillomavirus (HPV) DNA, hybrid capture II (HC II), compared with the previous commercialized hybrid capture I (HC I) and polymerase chain reaction (PCR) results on cervical scrapes from fresh cone excision biopsy samples. METHODS: The three methods were used on cervical scrapes from 42 fresh cone excision biopsy samples. There were nine metaplastic and inflammatory lesions, five low grade lesions, and 28 high grade lesions. PCR was performed using the general primers GP5+/GP6+. The viral load of high risk HPV DNA was estimated by the ratio of relative light units to positive control values in the samples. RESULTS: The sensitivity of HC I for the detection of high grade lesions was 71.4%, while it was 92.8% for HC II and 96.4% for the PCR. Considering only the absence of detectable cervical in situ neoplasia, the specificity was 88.9% for HC I, 66.7% for HC II, and 66.7% for PCR. With HC II, for a ratio of cervical sample to normal control of > 200, the sensitivity for the detection of high grade lesion was only 34.6% with a specificity of 66.7%. CONCLUSIONS: HPV detection with the HC II assay is more sensitive than the previous HC I and represents a more convenient and easier test than PCR for routine use. Nevertheless the viral load estimated with this test cannot be a reliable predictive indicator of high grade lesions.  (+info)

(7/50409) Comparative efficacy of positron emission tomography with FDG and computed tomographic scanning in preoperative staging of non-small cell lung cancer.

OBJECTIVE: To determine the sensitivity, specificity, and accuracy of positron emission tomography with 2-fluorine-18-fluorodeoxyglucose (PET-FDG) in the preoperative staging (N and M staging) of patients with lung cancer. The authors wanted to compare the efficacy of PET scanning with currently used computed tomography (CT) scanning. MATERIALS AND METHODS: Results of whole-body PET-FDG imaging and CT scans were compared with histologic findings for the presence or absence of lymph node disease or metastatic sites. Sampling of mediastinal lymph nodes was performed using mediastinoscopy or thoracotomy. RESULTS: PET-FDG imaging was significantly more sensitive, specific, and accurate for detecting N disease than CT. PET changed N staging in 35% and M staging in 11% of patients. CT scans helped in accurate anatomic localization of 6/57 PET lymph node abnormalities. CONCLUSION: PET-FDG is a reliable method for preoperative staging of patients with lung cancer and would help to optimize management of these patients. Accurate lymph node staging of lung cancer may be ideally performed by simultaneous review of PET and CT scans.  (+info)

(8/50409) Screening for congenital heart malformation in child health centres.

BACKGROUND: Although screening for congenital heart malformations is part of the child health care programme in several countries, there are very few published evaluations of these activities. This report is concerned with the evaluation of this screening at the Dutch Child Health Centres (CHC). METHODS: All consecutive patients, aged between 32 days and 4 years, presented at the Sophia Children's Hospital Rotterdam throughout a period of 2 years, with a congenital heart malformation were included in this study. Paediatric cardiologists established whether or not these patients were diagnosed after haemodynamic complications had already developed (diagnosed 'too late'). Parents and CHC-physicians were interviewed in order to establish the screening and detection history. Test properties were established for all patients with a congenital heart malformation (n = 290), intended effects of screening were established in patients with clinically significant malformations (n = 82). RESULTS: The sensitivity of the actual screening programme was 0.57 (95% CI : 0.51-0.62), the specificity 0.985 (95% CI : 0.981-0.990) and the predictive value of a positive test result 0.13 (95% CI: 0.10-0.19). Sensitivity in a subpopulation of patients adequately screened was 0.89 (95% CI: 0.74-0.96). Adequately screened patients were less likely to be diagnosed 'too late' than inadequately screened patients (odds ratio [OR] = 0.20, 95% CI: 0.04-1.05). The actual risk of being diagnosed 'too late' in the study-population (48%) was only slightly less than the estimated risk for patients not exposed to CHC-screening (58%, 95% CI: 43%-72%). Adequately screened patients however were at considerably less risk (17%, 95% CI: 4%-48%). CONCLUSION: Screening for congenital heart malformations in CHC contributes to the timely detection of these disorders. The actual yield, however, is far from optimal, and the screening programme should be improved.  (+info)


How long does it take sensitivity toothpaste to work?


I bought the colgate tooth paste fro tooth sensitivity, and i was wondering how long it usually takes before it gets rid of my sentivity.  

Also what is the difference between in pain between a cavity and tooth sensitivity? 

Thanks in advance, and ten points to the best answer.
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Tooth sensitivity is the reason why you need to use sensitive toothpaste. The pain is usually from cold foods and hot foods & can be from just touching your teeth. Pain from a cavity usually comes from biting down, food getting caught, cold drinks, breathing air, etc. A lot of times if you have a cold feeling or a broken tooth or a old filling in the tooth( with reccurent decay under it), sensitivity can mean you need a root canal ?


How to get the Sensitivity back on your penis gland?


I'm 14 years old and i was wondering how to get the sensitivity back on to my penis gland?
Many people over the internet say that it is more pleasuring to have intercourse when your penis gland is sensitivity. I'm Circumcised. I want to start from know to get the sensitivity back on my penis gland. 
Any idea how to get it without buying any product that are meant for that?
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The latest research indicates that it improves sexual pleasure so don't believe unsubstantiated internet information.
http://www.theaustralian.com.au/news/world/surgical-vaccine-helping-stop-hiv/story-e6frg6so-1226098865549

If you have a problem with sensitivity see a urologist. Your glans should be sensitive but many people find they have more sensitivity in their frenulum. That is the strip (assuming that your foreskin is sitting back) (if you pull your residual foreskin out it spreads out) of skin under your glans. Hopefully that is still working.

Rather than getting unsubstantiated information in here or otherwise online why not read the heavily referenced website of a medical research scientist who does a lot of research in the area ie. the link below


How do you increase the sensitivity of your penis?


I would like to increase the sensitivity of my penis. How can I accomplish this?
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The more you don't touch it (i.e. by not masturbating/having sex) for an extended amount of time, the more sensitive it'll seem.  If you're circumcised there are special products online to help increase sensitivity, or you can attempt to "recreate" your foreskin, though this is likely more effort than it's worth.

If you're uncircumcised, leave the foreskin over the glans for longer, but be sure to clean underneath the foreskin at least once a day during a shower (sensitivity is good, but bad hygiene is just bad).  Other than these situations, you can't really increase sensitivity, though you can train yourself to become more aware of the sensitivity you have.


What is the best way to whiten your teeth if you have sensitivity?


I have been trying to whiten my teeth with Crest WhiteStrips but quickly found out that my tooth sensitivity would prevent me from finishing with it.  I have heard that using baking soda works, but I am just looking for the best way possible.
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i would probably try baking soda bc you can just add that to ur regular toothpaste or mix it with water - but be careful not to use it long term or without the advice of ur dentist bc home things could damage ur teeth over time.

i would ask ur dentist what he thinks the best thing would be. i know that when i got my bleaching trays and gel from my dentist he said that sometimes placing some toothpaste for sensitive teeth into the trays (and/or brushing with it) can help with the sensitivity.

hope this helps! =)


I just started wearing a night guard to reduce my sensitivity caused by grinding. When can I bleach my teeth?


I want to bleach, but I don't want to do it too soon because I know that it will cause increased sensitivity on top of the sensitivity I've already been experiencing due to my grinding.  I just started using my night guard about four nights ago.  I've worn it consistantly (surprisingly) and do not remove it during the night.  I have noticed a markable decrease in my sensitivity, but I would like to know when I can start bleaching my teeth.
anyone??????
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After 4 weeks


How long should sensitivity last after a filling?


I've had a filling done and it's hurt for ages now, just wondering how long sensitivity should last? I don't know what material my dentist used to fill the cavity with because it's like on the side of the tooth at the back. I had it done in early February I think? I went back and he said there's nothing wrong with the filling and that I should floss.

HOW LONG WILL THIS PAIN GO OOOON?!
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There shouldn't be any pain after the first 48 hours. But the sensitivity would be there for a while it will be sensitive to heat and to cold. But if it becomes painful and unbearable go see your GP. And if its sensitive it is probably a silver filling as that absorbs any type of heat. Give it another week and go back. You shouldn't be experiencing any substantial pain.


How can I tell if I have a sensitivity to metal before I get my ears pierced?


I know that if you have sensitivity to metals you can't wear certain types of earrings, but I have no idea I am sensitive to metal, and I don't want to find out the hard way.
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Just start out with a gold stud, those are the safest, then, after you heal, try nickle, and you will see if you are or not the easy way.


What can be done to relieve teeth sensitivity and pain?


I have been having cold/hot sensitivity on my right upper side, in the back.  I had several fillings done, but months later, the pain is still there. The dentist says that I don't need a root canal, but doesn't know why I'm still having the sensitivity.  Can it be my wisdom teeth, or an infection? Do I have mouth cancer?  I also have constant pain in my lower right side.  Do I need a new dentist?  Sensitive toothpaste does not help.
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no, you'll have infection that has got to the inside of the tooth. The fillings may not have been placed deeply enough but there are many reasons why your dentist may not have initially done them so deeply. In other words, there may still be decay under the filling.

you'll need root canal treatment, that's it.

nothing else to worry about...from waht you say. unless you have white legions in your mouth i can say you probably don't have cancer.