Semicarbazides
Phyllanthus
Plant Extracts
Gastrodia
Picrates
Elevated activity of semicarbazide-sensitive amine oxidase in blood from patients with skeletal metastases of prostate cancer. (1/109)
The semicarbazide-sensitive amine oxidases constitute a group of copper-containing enzymes whose physiological function is unclear. The enzymes are present in various tissues, including blood plasma. At present, the source of the plasma enzyme in humans is not known. Results of a recent study suggested that semicarbazide-sensitive amine oxidase is expressed in the skeleton, e.g. in the spine. Using an indirect autoradiographic method in mice, we provide evidence that semicarbazide-sensitive amine oxidase is present in high abundance in bone tissue. Specific activities of semicarbazide-sensitive amine oxidase were estimated in blood samples from subjects with femoral bone fractures. Moreover, enzyme activities were also measured in patients suffering from prostate cancer with skeletal metastases. The level of specific semicarbazide-sensitive amine oxidase activity in serum was significantly elevated in patients with skeletal metastases compared with both healthy controls and patients having prostate cancer without signs of skeletal metastases. Based on the results of the present study, we propose that semicarbazide-sensitive amine oxidase in blood plasma may originate, at least in part, from the skeleton. (+info)Simultaneous determination of formaldehyde and methylglyoxal in urine: involvement of semicarbazide-sensitive amine oxidase-mediated deamination in diabetic complications. (2/109)
The deamination of methylamine and aminoacetone by semicarbazide-sensitive amine oxidase (SSAO) produces formaldehyde and methylglyoxal, respectively, which have been presumed to be involved in diabetic complications. A high-performance liquid chromatography procedure using 2,4-dinitrophenylhydrazine (DNPH) as a derivatizing agent is developed to determine endogenous formaldehyde, methylglyoxal, malondialdehyde, and acetaldehyde. The devised DNPH method is sensitive enough to analyze aldehyde levels in urine. An increase in the excretion of formaldehyde, methylglyoxal, and malondialdehyde is confirmed in streptozotocin-induced diabetic rats. Following the chronic administration of methylamine, the urinary levels of both formaldehyde and malondialdehyde (a product from lipid peroxidation) are found to be substantially increased. A potent selective SSAO inhibitor, (E)-2-(4-fluorophenethyl)-3-fluoroallylamine hydrochloride (MDL-72974A), reduced the formation of formaldehyde, methylglyoxal, and malondialdehyde. The increase of the cytotoxic aldehyde levels as a result of increased SSAO-mediated deamination may occur in some pathological conditions. (+info)S-adenosylmethionine decarboxylase from baker's yeast. (3/109)
1. S-Adenosyl-L-methionine decarboxylase (S-adenosyl-L-methionine carboxy-lyase, EC 4.1.1.50) was purified more than 1100-fold from extracts of Saccharomyces cerevisiae by affinity chromatography on columns of Sepharose containing covalently bound methylglyoxal bis(guanylhydrazone) (1,1'[(methylethanediylidene)dinitrilo]diguanidine) [Pegg, (1974) Biochem J. 141, 581-583]. The final preparation appeared to be homogeneous on polyacrylamide-gel electrophoresis at pH 8.4. 2. S-Adenosylmethionine decarboxylase activity was completely separated from spermidine synthase activity [5'-deoxyadenosyl-(5'),3-aminopropyl-(1),methylsulphonium-salt-putrescine 3-aminopropyltransferase, EC 2.5.1.16] during the purification procedure. 3. Adenosylmethionine decarboxylase activity from crude extracts of baker's yeast was stimulated by putrescine, 1,3-diamino-propane, cadaverine (1,5-diaminopentane) and spermidine; however, the purified enzyme, although still stimulated by the diamines, was completely insensitive to spermidine. 4. Adenosylmethionine decarboxylase has an apparent Km value of 0.09 mM for adenosylmethionine in the presence of saturating concentrations of putrescine. The omission of putrescine resulted in a five-fold increase in the apparent Km value for adenosylmethionine. 5. The apparent Ka value for putrescine, as the activator of the reaction, was 0.012 mM. 6. Methylglyoxal bis(guanylhydrazone) and S-methyladenosylhomocysteamine (decarboxylated adenosylmethionine) were powerful inhibitors of the enzyme. 7. Adenosylmethionine decarboxylase from baker's yeast was inhibited by a number of conventional carbonyl reagents, but in no case could the inhibition be reversed with exogenous pyridoxal 5'-phosphate. (+info)Effects of a molecular change in collagen on lung structure and mechanical function. (4/109)
Semicarbazide, a lathyrogen, was given to growing rats to elucidate the consequences of altering the molecular structure of fibrous proteins within the lung. Static pressure-volume (P-V) measurements during deflation of saline-filled lungs showed normal recoil pressure and compliance values within the physiological range of lung volume. Quasi-static P-V measurements were also normal during slow reinflation, even beyond physiological limits to a recoil pressure of 20 cm H20. However, the lungs of experimental rats ruptured at much lower recoil pressures than controls. Histology was normal in lungs fixed at 20 cm H20. In contrast, lungs showed dilation of terminal air spaces, rupture of alveolar walls, and an increase in mean linear intercept in experimental compared with control specimens, when fixed at 30 cm H20. Biochemical analyses revealed reduced cross-linking of lung collagen without change in its total content. There were no detectable changes in the quantity or quality of lung elastin. It is concluded that semicarbazide may selectively impair the maturation of lung collagen and that immaturity of lung collagen is associated with a reduction in the tensile strength of lung tissue, without changes in elasticity within physiological volume limits. (+info)Lesion of the ventral periaqueductal gray reduces conditioned fear but does not change freezing induced by stimulation of the dorsal periaqueductal gray. (5/109)
Previously-reported evidence showed that freezing to a context previously associated with footshock is impaired by lesion of the ventral periaqueductal gray (vPAG). It has also been shown that stepwise increase in the intensity of the electrical stimulation of the dorsal periaqueductal gray (dPAG) produces alertness, then freezing, and finally escape. These aversive responses are mimicked by microinjections of GABA receptor antagonists, such as bicuculline, or blockers of the glutamic acid decarboxylase (GAD), such as semicarbazide, into the dPAG. In this work, we examined whether the expression of these defensive responses could be the result of activation of ventral portion of the periaqueductal gray. Sham- or vPAG electrolytic-lesioned rats were implanted with an electrode in the dPAG for the determination of the thresholds of freezing and escape responses. The vPAG electrolytic lesions were behaviorally verified through a context-conditioned fear paradigm. Results indicated that lesion of the vPAG disrupted conditioned freezing response to contextual cues associated with footshocks but did not change the dPAG electrical stimulation for freezing and escape responses. In a second experiment, lesion of the vPAG also did not change the amount of freezing and escape behavior produced by microinjections of semicarbazide into the dPAG. These findings indicate that freezing and escape defensive responses induced by dPAG stimulation do not depend on the integrity of the vPAG. A discussion on different neural circuitries that might underlie different inhibitory and active defensive behavioral patterns that animals display during threatening situations is presented. (+info)Microbial metabolism of the pyridine ring. Metabolic pathways of pyridine biodegradation by soil bacteria. (6/109)
1. Two bacteria, a Bacillus sp. and a Nocardia sp. (strain Z1) were isolated from soil by enrichment with 0.1 percent (v/v) pyridine and grew rapidly on this compound as sole C, N and energy source. The monohydroxypyridines, tetrahydropyridine, piperidine and some other analogues were not utilized for growth or oxidized by washed suspensions of either bacterium. 2. Cell-free extracts were unable to metabolize pyridine even after supplementation with a variety of cofactors or protecting agents. Treatment of cells with toluene led to rapid loss of the ability to oxidize pyridine. 3. In the presence of 10mM-semicarbazide at pH 6.0, Nocardia Z1 accumulated a semialdehyde idenditied as its 2,4-dinitrophenylhydrazone by chromatography, mixed melting point, mass spectrometry and isotope trapping from [2,6(-14)C]pyridine as glutarate semialdehyde. 4. Extracts of this bacterium prepared from cells grown with pyridine or exposed to the gratuitous inducer 2-picoline, contained high activities of a specific glutarate semialdehyde dehydrogenase. 5. Cells grown with pyridine or glutarate also contained a glutaric dialdehyde dehydrogenase, an acyl-CoA synthetase and elevated amounts of isocitrate lyase but no glutaryl-CoA dehydrogenase. 6. Bacillus 4 accumulated in the presence of 10mM-semicarbazide several acidic carbonyl compounds from pyridine among which was succinate semialdehyde. Extracts of this bacillus after growth of the cells with pyridine contained an inducible succinate semialdehyde dehydrogenase in amounts at least 50-fold over those found in succinate-grown cells. 7. Two mutants of this bacillus, selected for their inability to grow on pyridine were deficient in succinate semialdehyde dehydrogenase. 8. In the presence of 0.2mM-KCN, washed suspensions of Bacillus 4 accumulated formate and possibly formamide from pyridine. The use of [14C]pyridine showed that formate was derived from C-2 of the pyridine ring. 9. The organism had a specific formamide amidohydrolase cleaving formamide quantitatively to formate and NH3. 10. Formate was further oxidized by the particle fraction. There was no soluble formate dehydrogenase in extracts. (+info)Semicarbazide-sensitive amine oxidase activation promotes adipose conversion of 3T3-L1 cells. (7/109)
Semicarbazide-sensitive amine oxidase (SSAO) is an amine oxidase related to the copper-containing amine oxidase family. The tissular form of SSAO is located at the plasma membrane, and is mainly expressed in vascular smooth muscle cells and adipocytes. Recent studies have suggested that SSAO could activate glucose transport in fat cells. In the present work, we investigated the potential role of a chronic SSAO activation on adipocyte maturation of the 3T3-L1 pre-adipose cell line. Exposure of post-confluent 3T3-L1 pre-adipocytes to methylamine, a physiological substrate of SSAO, promoted adipocyte differentiation in a time- and dose-dependent manner. This effect could be related to SSAO activation, since it was antagonized in the presence of the SSAO inhibitor semicarbazide, but not in the presence of the monoamine oxidase inhibitor pargyline. In addition, methylamine-induced adipocyte maturation was mimicked by 3T3-L1 cell treatment with other SSAO substrates. Finally, the large reversion of methylamine action by catalase indicated that hydrogen peroxide generated by SSAO was involved, at least in part, in the modulation of adipocyte maturation. Taken together, our results suggest that SSAO may contribute to the control of adipose tissue development. (+info)Combined treatment with benzylamine and low dosages of vanadate enhances glucose tolerance and reduces hyperglycemia in streptozotocin-induced diabetic rats. (8/109)
Semicarbazide-sensitive amine oxidase (SSAO) is highly expressed in adipose cells, and substrates of SSAO, such as benzylamine, in combination with low concentrations of vanadate strongly stimulate glucose transport and GLUT4 recruitment in 3T3-L1 and rat adipocytes. Here we examined whether acute and chronic administration of benzylamine and vanadate in vivo enhances glucose tolerance and reduces hyperglycemia in diabetic rats. Acute intravenous administration of these drugs enhanced glucose tolerance in nondiabetic rats and in streptozotocin (STZ)-induced diabetic rats. This occurred in the absence of changes in plasma insulin concentrations. However, the administration of benzylamine or vanadate alone did not improve glucose tolerance. The improvement caused by benzylamine plus vanadate was abolished when rats were pretreated with the SSAO-inhibitor semicarbazide. Chronic administration of benzylamine and vanadate exerted potent antidiabetic effects in STZ-induced diabetic rats. Although daily administration of vanadate alone (50 and 25 micromol x kg(-1) x day(-1) i.p.) for 2 weeks had little or no effect on glycemia, vanadate plus benzylamine reduced hyperglycemia in diabetic rats, enhanced basal and insulin-stimulated glucose transport, and upregulated GLUT4 expression in isolated adipocytes. In all, our results substantiated that acute and chronic administration of benzylamine with low dosages of vanadate have potent antidiabetic effects in rats. (+info)Semicarbazides are organic compounds that contain the functional group -NH-CO-NH-NH2. They are derivatives of hydrazine and carbamic acid, with the general structure (CH3)NHCSNH2. Semicarbazides are widely used in the synthesis of various chemical compounds, including heterocyclic compounds, pharmaceuticals, and agrochemicals.
In a medical context, semicarbazides themselves do not have any therapeutic use. However, they can be used in the preparation of certain drugs or drug intermediates. For example, semicarbazones, which are derivatives of semicarbazides, can be used to synthesize some antituberculosis drugs.
It is worth noting that semicarbazides and their derivatives have been found to have mutagenic and carcinogenic properties in some studies. Therefore, they should be handled with care in laboratory settings, and exposure should be minimized to reduce potential health risks.
"Phyllanthus" is a genus of flowering plants and does not have a specific medical definition. However, certain species of Phyllanthus are used in traditional medicine and herbal remedies. For example:
* Phyllanthus amarus is used in Ayurvedic medicine for treating liver disorders and diabetes.
* Phyllanthus niruri is also used in traditional medicine for treating liver problems, kidney stones, and digestive issues.
* Phyllanthus emblica, also known as Indian gooseberry, is commonly used in Ayurvedic medicine for its antioxidant and anti-inflammatory properties.
It's important to note that while some Phyllanthus species have been studied for their potential medicinal benefits, more research is needed before they can be recommended as standard treatments. Additionally, herbal supplements can interact with prescription medications and may not be safe for everyone, so it's always best to consult with a healthcare provider before starting any new treatment regimen.
Phyllanthus emblica, also known as Emblica officinalis or Amla, is a plant species native to India and Southeast Asia. In the context of medicine, particularly in Ayurvedic medicine, the fruit of Phyllanthus emblica is used.
Medical definitions describe Phyllanthus emblica as a:
1. Rising drug: A substance of plant origin used in traditional Ayurvedic medicine, primarily in the Indian subcontinent.
2. Fruit of an Asian tree (Phyllanthus emblica) that contains various bioactive compounds such as phenolic acids, flavonoids, tannins, and alkaloids.
3. Traditional Ayurvedic remedy with antioxidant, anti-inflammatory, immunomodulatory, and gastroprotective properties.
4. A rich source of vitamin C and other nutrients such as calcium, iron, and carotene.
5. Used in various Ayurvedic formulations for treating conditions like diabetes, indigestion, jaundice, and skin disorders.
6. May help improve cognitive function, liver health, and cardiovascular health based on preliminary research. However, more extensive clinical trials are needed to confirm these potential benefits.
A plant extract is a preparation containing chemical constituents that have been extracted from a plant using a solvent. The resulting extract may contain a single compound or a mixture of several compounds, depending on the extraction process and the specific plant material used. These extracts are often used in various industries including pharmaceuticals, nutraceuticals, cosmetics, and food and beverage, due to their potential therapeutic or beneficial properties. The composition of plant extracts can vary widely, and it is important to ensure their quality, safety, and efficacy before use in any application.
Phenols, also known as phenolic acids or phenol derivatives, are a class of chemical compounds consisting of a hydroxyl group (-OH) attached to an aromatic hydrocarbon ring. In the context of medicine and biology, phenols are often referred to as a type of antioxidant that can be found in various foods and plants.
Phenols have the ability to neutralize free radicals, which are unstable molecules that can cause damage to cells and contribute to the development of chronic diseases such as cancer, heart disease, and neurodegenerative disorders. Some common examples of phenolic compounds include gallic acid, caffeic acid, ferulic acid, and ellagic acid, among many others.
Phenols can also have various pharmacological activities, including anti-inflammatory, antimicrobial, and analgesic effects. However, some phenolic compounds can also be toxic or irritating to the body in high concentrations, so their use as therapeutic agents must be carefully monitored and controlled.
Gastrodia is the name of a genus of plants, but in a medical context, "Gastrodia" most commonly refers to Gastrodia elata, a species of orchid that is native to China and other parts of East Asia. This plant has been used in traditional Chinese medicine for centuries to treat various conditions, including headaches, seizures, and nervous disorders.
The primary active component of Gastrodia is thought to be gastrodin, a phenolic glycoside that has been shown to have anti-inflammatory, antioxidant, and neuroprotective effects in laboratory studies. However, more research is needed to fully understand the medicinal properties of this plant and its potential therapeutic uses.
It's important to note that while Gastrodia has a long history of use in traditional medicine, it should not be used as a substitute for modern medical treatment. If you are considering using Gastrodia or any other herbal supplement, it's important to talk to your healthcare provider first to ensure that it is safe and appropriate for your individual health needs.
I am not a medical expert, but I can provide some information that may be helpful. "Picrates" is not a term commonly used in medical definitions. Instead, it is a term used in chemistry to refer to salts of picric acid (2,4,6-trinitrophenol), which was once used as a yellow dye and explosive.
Picric acid has been used historically in some medical applications, such as a component in certain topical antiseptics and in histological staining procedures. However, its use in modern medicine is quite limited due to its high sensitivity to impact, heat, and friction, which makes it potentially dangerous to handle.
Therefore, it's important to note that "picrates" is not a medical term per se but rather a chemical one, and any medical application of picric acid or its salts would be highly specialized and unlikely to be encountered in most healthcare settings.
Aerial parts of plants refer to the above-ground portions of a plant, including leaves, stems, flowers, and fruits. These parts are often used in medicine, either in their entirety or as isolated extracts, to take advantage of their medicinal properties. The specific components of aerial parts that are used in medicine can vary depending on the plant species and the desired therapeutic effects. For example, the leaves of some plants may contain active compounds that have anti-inflammatory or analgesic properties, while the flowers of others may be rich in antioxidants or compounds with sedative effects. In general, aerial parts of plants are used in herbal medicine to treat a wide range of conditions, including respiratory, digestive, and nervous system disorders, as well as skin conditions and infections.
Semicarbazide
Semicarbazide-cadmium therapy
Carbazide
Transamidation
Azodicarbonamide
Marguerite Lwoff
Phenicarbazide
Thiosemicarbazone
AOC3
Α-Methyltryptamine
Oligonucleotide synthesis
Primary-amine oxidase
Phenethylamine
Nucleophile
Potassium cyanate
Amiflamine
Osteolathyrism
Semicarbazone
Nitrotriazolone
Food contaminant
4-Phenylthiosemicarbazide
4-Methyl-3-thiosemicarbazide
Biurea
Thiosemicarbazide
Synthetic drug
SSAO
Mofegiline
EPA list of extremely hazardous substances
IARC group 3
Semicarbazide - Wikipedia
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Amine oxidase2
- Studies of monoamine oxidase and semicarbazide-sensitive amine oxidase. (erowid.org)
- Geraniin, a tannin from P. urinaria , was reported to exhibit semicarbazide-sensitive amine oxidase inhibitory, antioxidant, and antihypertensive activities [ 4 ]. (ijpsonline.com)
Azodicarbonamide1
- When used as endothermic blowing agent in the plastics industry, it is the preferred food grade, non-toxic alternative to exothermic blowing agents such as azo compounds (e.g. azodicarbonamide), hydrazine derivatives or semicarbazides. (jungbunzlauer.com)
Hydrazine2
- The compound prepared by treating urea with hydrazine: OC(NH2)2 + N2H4 → OC(NH2)(N2H3) + NH3 A further reaction can occur to give carbohydrazide: OC(NH2)(N2H3) + N2H4 → OC(N2H3)2 + NH3 Semicarbazide is frequently reacted with aldehydes and ketones to produce semicarbazones via a condensation reaction. (wikipedia.org)
- Biurea - another product of reaction of urea with hydrazine Carbazide - structurally related with the general formula (R2NNH)2C(O) Semicarbazide-cadmium therapy thiosemicarbazide CID 5196 from PubChem Jean-Pierre Schirmann, Paul Bourdauducq "Hydrazine" in Ullmann's Encyclopedia of Industrial Chemistry, Wiley-VCH, Weinheim, 2002. (wikipedia.org)
Derivatives1
- Reactions of Carbamic Acid Derivatives to Give Semicarbazides 4. (elsevier.com)
Formula1
- Semicarbazide is the chemical compound with the formula OC(NH2)(N2H3). (wikipedia.org)
Chemical1
- The first chemical is semicarbazide (SEM), which has been linked to cancer of the lungs and blood vessels in mice, but not in rats, and the second chemical is urethane, which has been linked to cancer. (thehealthy.com)
Cells2
- Semicarbazide products (semicarbazones and thiosemicarbazones) are known to have an activity of antiviral, antiinfective and antineoplastic through binding to copper or iron in cells. (wikipedia.org)
- Optimisation and validation of a sensitive high-performance liquid chromatography assay for routine measurement of pyridoxal 5-phosphate in human plasma and red cells using pre-column semicarbazide derivatisation. (kcl.ac.uk)
Product1
- Another breakdown product is semicarbazide, which poses "a negligible risk to humans" but was found to cause cancers of the lung and blood vessels in mice, CSPI said. (cnn.com)
Amine16
- Additionally, AA toxicity is likely dependent on the enzyme semicarbazide-sensitive amine oxidase (SSAO), which is highly expressed in the aorta of rats and humans. (nih.gov)
- 6. Immunohistochemical study of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 in the hippocampal vasculature: pathological synergy of Alzheimer's disease and diabetes mellitus. (nih.gov)
- 9. The contribution of cerebral vascular semicarbazide-sensitive amine oxidase to cerebral amyloid angiopathy in Alzheimer's disease. (nih.gov)
- 10. Involvement of cerebrovascular semicarbazide-sensitive amine oxidase in the pathogenesis of Alzheimer's disease and vascular dementia. (nih.gov)
- 12. Soluble Vascular Adhesion Protein-1 Mediates Spermine Oxidation as Semicarbazide-Sensitive Amine Oxidase: Possible Role in Proliferative Diabetic Retinopathy. (nih.gov)
- 13. Origins of serum semicarbazide-sensitive amine oxidase. (nih.gov)
- 16. Inhibition of semicarbazide-sensitive amine oxidase reduces atherosclerosis in apolipoprotein E-deficient mice. (nih.gov)
- 17. Semicarbazide sensitive amine oxidase overexpression has dual consequences: insulin mimicry and diabetes-like complications. (nih.gov)
- 18. Anti-inflammatory effects of inhibiting the amine oxidase activity of semicarbazide-sensitive amine oxidase. (nih.gov)
- Geraniin, a tannin from P. urinaria , was reported to exhibit semicarbazide-sensitive amine oxidase inhibitory, antioxidant, and antihypertensive activities [ 4 ]. (ijpsonline.com)
- AOC3 / VAP-1 is a member of the semicarbazide-sensitive amine oxidase family. (lsbio.com)
- The Danish pharma has bought an exclusive worldwide licence from Japan's UBE for UD-014, a selective semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1) inhibitor small molecule. (pharmaphorum.com)
- Exploring the binding mode of semicarbazide-sensitive amine oxidase/VAP-1: identification of novel substrates with insulin-like activity. (ub.es)
- The Biological Implication of Semicarbazide-Sensitive Amine Oxidase (SSAO) Upregulation in Rat Systemic Inflammatory Response under Simulated Aerospace Environment. (dcgable.com)
- Launch Human major amine oxidase (AOC3) also called vascular adhesion proteins-1 (VAP-1) or semicarbazide-sensitive amine oxidase (SSAO) continues to be investigated being a potential medication focus on of inflammatory illnesses due to its participation in leukocyte trafficking. (buyresearchchemicalss.net)
- VAP-1 is one of the category of copper-containing amine oxidase/semicarbazide-sensitive amine oxidase (CAO/SSAO) enzymes. (buyresearchchemicalss.net)
Hydrochloride2
Semicarbazones3
- The compound prepared by treating urea with hydrazine: OC(NH2)2 + N2H4 → OC(NH2)(N2H3) + NH3 A further reaction can occur to give carbohydrazide: OC(NH2)(N2H3) + N2H4 → OC(N2H3)2 + NH3 Semicarbazide is frequently reacted with aldehydes and ketones to produce semicarbazones via a condensation reaction. (wikipedia.org)
- Semicarbazide products (semicarbazones and thiosemicarbazones) are known to have an activity of antiviral, antiinfective and antineoplastic through binding to copper or iron in cells. (wikipedia.org)
- Thus, the corresponding 2-amino-3-furancarboxaldehyde phenylhydrazones and semicarbazones were obtained upon treatment with phenylhydrazine and semicarbazide, respectively, whereas condensation with malononitrile yielded 2-substituted 6-aminofuro[2,3- b ]pyridine-5-carbonitriles. (enamine.net)
Carbazide1
- Biurea - another product of reaction of urea with hydrazine Carbazide - structurally related with the general formula (R2NNH)2C(O) Semicarbazide-cadmium therapy thiosemicarbazide CID 5196 from PubChem Jean-Pierre Schirmann, Paul Bourdauducq "Hydrazine" in Ullmann's Encyclopedia of Industrial Chemistry, Wiley-VCH, Weinheim, 2002. (wikipedia.org)
Inhibitor1
- The subcellular distribution of the protein was not altered in a catalytically inactive mutant form of the protein (Tyr471Phe) or in the presence of exogenous VAP-1 substrate (methylamine) or inhibitor (semicarbazide). (birmingham.ac.uk)
Conjugate1
- The aldehyde function is often used to conjugate biopolymers to other molecules via reductive amination or adduct formation with hydroxylamines, hydrazines, and semicarbazides. (biosearchtech.com)
Inhibition1
- They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC 1.4.3.4, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. (cathdb.info)
Chemical compound1
- Semicarbazide is the chemical compound with the formula OC(NH2)(N2H3). (wikipedia.org)
Toxicity2
Https1
- nonassimilable illaudable visit begun https://gestalte.be/gestalte-aankoop-finasteride-met-mastercard an semicarbazide. (algec.org)
Methods1
- Miscellaneous Methods References Chapter 8/Semicarbazides 1. (elsevier.com)
Series1
- A series of new 1-Glycosyl-4-(2,4-dinitrophenyl) semicarbazides have been synthesized by the interaction of various Glycosyl isocyanates and 2,4-Dinitrophenyl hydrazine. (derpharmachemica.com)
Presence1
- Myocytes exposed to 1mM allylamine in the presence of 0.1mM semicarbazide maintained normal ATP levels. (cdc.gov)