Roseolovirus Infections
Roseolovirus
Herpesvirus 7, Human
Betaherpesvirinae
Exanthema Subitum
Herpesvirus 6, Human
Encyclopedias as Topic
The utility of plasma polymerase chain reaction for human herpes virus-6 among pediatric bone marrow transplant recipients: results of a pilot study. (1/169)
We evaluated the utility of plasma polymerase chain reaction (PCR) for surveillance of human herpes virus 6 (HHV-6) infection among pediatric bone marrow transplant (BMT) recipients. We used a prospective, non-interventional design involving a study group and controls. BMT recipients and healthy controls were evaluated. BMT subjects had HHV-6 PCR done biweekly for 12 weeks post transplantation, while a single PCR test was done on controls. For the PCR assay, EDTA blood was collected and DNA extracted from whole blood and cell-free plasma using standard procedures. The PCR was first performed on DNA from whole blood and if a positive result was obtained, the test was repeated on the DNA from the plasma. Thirty BMT recipients (13 autologous and 17 allogeneic) were enrolled, on whom a total of 156 PCR tests were performed, while six tests were done on six healthy controls. The median age of BMT subjects was 6.2 years (range 0.5-17.5 years). The median age of the control subjects was 6.6 years (range 2-10 years). Among asymptomatic BMT patients who had PCR surveillance, the positivity rate was 3.3% (1/30) on whole blood and 0% (0/30) on plasma. None of the six healthy subjects had a positive PCR test on whole blood. During the period of the surveillance study, 14 patients had diagnostic evaluations for HHV-6 disease because of clinical symptoms. Two of these patients were diagnosed with disease associated with HHV-6 (graft failure and encephalitis) and had positive PCR tests on whole blood and plasma and whole blood and cerebrospinal fluid, respectively. We conclude that despite the fact that HHV-6 seropositivity rates are high among children, the frequency of HHV-6 plasma PCR positivity is low in pediatric BMT subjects who are asymptomatic for HHV-6 disease. Given that a positive test on plasma is consistent with active infection, this increases the utility of the PCR test as a diagnostic aid in evaluating syndromes presumed to be due to HHV-6 in pediatric bone marrow transplant recipients. (+info)Genetic polymorphism of human herpesvirus-7 among human populations. (2/169)
The analysis of three human herpesvirus-7 (HHV-7) genes encoding phosphoprotein p100, glycoprotein B and major capsid protein respectively had previously shown the existence of distinct gene alleles, leading to the concept of HHV-7 variants. We have analysed the distribution of HHV-7 variants among 297 distinct subjects who belonged to different human populations from Africa, Asia, Europe and America. Two variants, designated Co1 and Co2, were found in 52% and 20% of studied subjects. Ten other variants, designated Co3-Co12, were less frequent and classified into two groups related to Co1 and Co2 respectively. While the former group was ubiquitous and the most frequent in Africa and Asia, the latter one was predominantly found in European and Mongol populations. Despite the high stability of the HHV-7 genome, a few nucleotide substitutions at precise positions define distinct variants which, to some extent, behave as markers of human populations. (+info)Human herpesvirus 6-associated hemophagocytic syndrome in a healthy adult. (3/169)
Virus-associated hemophagocytic syndrome is a fulminant disorder associated with systemic viral infection and characterized pathologically by multiple-organ infiltration of hemophagocytic histiocytes into the lymphoreticular tissues. This is the first report of a previously healthy adult in whom Human herpesvirus 6 reactivation induced this syndrome with severe hemodynamic and respiratory distress. (+info)Selective reactivation of human herpesvirus 6 variant a occurs in critically ill immunocompetent hosts. (4/169)
Reactivation of human beta-herpesviruses (cytomegalovirus [CMV], human herpesvirus [HHV]-6, and HHV-7) in nonimmunocompromised hosts is rare. Because these viruses are susceptible to reactivation by cytokines and stress-related mechanisms, the incidence of their reactivation was investigated among 120 patients during stress related to critical illness and compared with findings among 50 healthy volunteers. Human beta-herpesvirus DNA was found in 65% of critically ill patients (60% men; mean age, 63 years) who required admission to an intensive care unit for medical (40%) or surgical (53%) indications or trauma (7%). HHV-6 reactivation was higher in critically ill patients than in healthy volunteers (54/101 vs. 0/50; P=.001). All patients except 1 were confirmed as HHV-6 variant A (mean virus load, 5066 copies/10(6) peripheral blood leukocytes). The reactivation of HHV-6A did not affect disease severity and outcome. No significant reactivation of HHV-7 or CMV was demonstrated among the critically ill patients. These findings contribute to the less-defined epidemiology of HHV-6A infection. (+info)Immune reactivity of human sera to the glycoprotein B of human herpesvirus 7. (5/169)
The glycoprotein B (gB) is highly conserved among distinct human herpesvirus 7 (HHV-7) strains. Similarly to other herpesvirus glycoproteins, gB has been assumed to induce a specific human immune response. However, it did not appear as an immunodominant protein in conventional immunoblot assays. Recombinant gB, obtained from either Escherichia coli or baculovirus expression systems, did react specifically with HHV-7-seropositive sera, and the main corresponding epitopes were located in its N-terminal part. A 24-amino-acid peptide, corresponding to a predicted hydrophilicity peak and presenting no extensive homology with other betaherpesvirus glycoproteins, was selected in this region at positions 129 to 152 of the gB sequence. When tested by enzyme-linked immunosorbent assay (ELISA), this peptide specifically reacted with HHV-7-seropositive sera. This reactivity was significantly inhibited by the preincubation of sera with the peptide itself, lysates of gB-expressing cells, or lysates of HHV-7-infected cells. The reactivity was not significantly modified when sera were preincubated with lysates of either human cytomegalovirus (HCMV)- or HHV-6-infected cells. In cross-sectional studies including both children and adults, 49 out of 61 serum samples (80%) were found to be positive by HHV-7 ELISA, independent of their reactivity to HCMV. A longitudinal serological study of 17 children during the first 4 years of life showed that the level of ELISA-detected antibodies significantly decreased within a few weeks after birth and then increased in the following months, likely reflecting, respectively, the loss of maternal antibodies and the occurrence of seroconversion. These results demonstrate that gB peptide ELISA might be a useful tool for the serological study of HHV-7 infection. (+info)Effect of antivirals on human herpesvirus 6 replication in hematopoietic stem cell transplant recipients. (6/169)
Human herpesvirus 6 (HHV-6) appears to cause central nervous system (CNS) syndromes, especially in hematopoietic stem cell transplant (HSCT) recipients. We reviewed our experience with HHV-6-associated CNS disease to evaluate both the clinical and virological presentation and response to antiviral therapy. A search of our virology database from January 1998 through June 2000 identified 11 HSCT recipients who had HHV-6 DNA detected by polymerase chain reaction in cerebrospinal fluid (CSF); 8 of whom had CNS dysfunction without another clear etiology identified. HHV-6 levels in serum and CSF were evaluated before and after ganciclovir and/or foscarnet therapy. Median log HHV-6 CSF levels appeared to decrease over time concurrent with antiviral therapy (serum level, 2.0 vs. 0 copies/mL [P=.38]; CSF level, 4.4 vs. 2.0 copies/mL [P=.13], sign test). Our data suggests that HHV-6 may cause moderate to severe CNS disease after HSC transplantation. Prospective studies are needed to define the spectrum of HHV-6-associated disease and to determine whether antiviral therapy offers clinical benefit. (+info)Influenza encephalopathy associated with infection with human herpesvirus 6 and/or human herpesvirus 7. (7/169)
Influenza-associated encephalopathy is often reported in young Japanese children, but its pathogenesis is unknown. Although influenza virus can be demonstrated by throat culture for patients with encephalopathy, cultures of samples of cerebrospinal fluids (CSF) do not yield the virus. Eight patients with encephalopathy or complicated febrile convulsions had influenza virus infection diagnosed by means of culture, polymerase chain reaction (PCR), or rapid diagnosis using throat swabs. In all 8 cases, the results of PCR testing of CSF specimens for influenza virus were negative. On the other hand, human herpesvirus 6 (HHV-6) DNA was demonstrated in CSF specimens obtained from 2 of 8 patients. In 3 of 8 patients, the presence of human herpesvirus 7 (HHV-7) DNA was demonstrated in CSF specimens. Some cases of influenza-associated encephalopathy reported in Japan may be attributable to a dual infection with influenza virus and HHV-6, -7, or both. Another possibility is that latent HHV-6 or HHV-7 in the brain is reactivated by influenza, causing encephalopathy or febrile convulsions. (+info)High incidence of Epstein-Barr virus, cytomegalovirus and human herpesvirus 6 infections in children with cancer. (8/169)
BACKGROUND: A prospective single-center study was performed to study infection with lymphotropic herpesviruses (LH) Epstein-Barr virus (EBV), cytomegalovirus (CMV) and human herpesvirus 6 (HHV-6) in children with cancer. METHODS: The group of 186 children was examined for the presence of LH before, during and 2 months after the end of anticancer treatment. Serology of EBV and CMV was monitored in all children, serology of HHV-6 and DNA analysis of all three LH was monitored in 70 children. RESULTS: At the time of cancer diagnosis (pre-treatment), there was no difference between cancer patients and age-matched healthy controls in overall IgG seropositivity for EBV (68.8% vs. 72.0%; p = 0.47) and CMV (37.6% vs. 41.7%; p = 0.36). During anticancer therapy, primary or reactivated EBV and CMV infection was present in 65 (34.9%) and 66 (35.4%) of 186 patients, respectively, leading to increased overall post-treatment IgG seropositivity that was significantly different from controls for EBV (86.6% vs. 72.0%; p = 0.0004) and CMV (67.7% vs. 41.7%; p < 0.0001). Overall pre-treatment IgG seropositivity for HHV-6 was significantly lower in patients than in controls (80.6% vs. 91.3%; p = 0.0231) which may be in agreement with Greaves hypothesis of protective effect of common infections in infancy to cancer development. Primary or reactivated HHV-6 infection was present in 23 (32.9%) of 70 patients during anticancer therapy leading to post-treatment IgG seropositivity that was not significantly different from controls (94.3% vs. 91.3%; p = 0.58). The LH infection occurred independently from leukodepleted blood transfusions given. Combination of serology and DNA analysis in detection of symptomatic EBV or CMV infection was superior to serology alone. CONCLUSION: EBV, CMV and HHV-6 infections are frequently present during therapy of pediatric malignancy. (+info)Roseolovirus infections are typically caused by human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7). The most common manifestation of roseolovirus infection is exanthem subitum, also known as roseola infantum or sixth disease, which primarily affects children aged 6 months to 2 years.
The infection usually begins with a fever that can last for up to a week, followed by the appearance of a rash once the fever subsides. The rash is typically pinkish-red, maculopapular (consisting of both flat and raised lesions), and appears on the trunk, spreading to the face, neck, and extremities. It usually lasts for 1-2 days.
In addition to exanthem subitum, roseolovirus infections can also cause a variety of other clinical manifestations, including febrile seizures, hepatitis, pneumonitis, myocarditis, and encephalitis. HHV-6 and HHV-7 have also been associated with several chronic diseases, such as chronic fatigue syndrome, multiple sclerosis, and certain malignancies.
Transmission of roseolovirus occurs through saliva and other bodily fluids, and primary infection is usually acquired during childhood. Once infected, the virus remains latent in the body and can reactivate later in life, although reactivation rarely causes symptoms.
Roseolovirus is a genus of viruses in the family Herpesviridae, subfamily Betaherpesvirinae. The genus contains three species: Human herpesvirus 6A (HHV-6A), Human herpesvirus 6B (HHV-6B), and Human herpesvirus 7 (HHV-7). These viruses are closely related and cause similar diseases, most notably exanthema subitum or roseola in infants and young children.
The primary infection with HHV-6A and HHV-6B typically occurs during the first two years of life and is usually asymptomatic or associated with mild symptoms such as fever and rash (roseola). After the primary infection, the virus becomes latent in the host's immune cells and may reactivate later in life, causing various clinical manifestations, including febrile illnesses, seizures, and central nervous system disorders.
HHV-7 is also a common infectious agent in humans, primarily causing exanthema subitum or roseola in children. It can also establish latency and reactivate, although its association with specific diseases is less clear than that of HHV-6A and HHV-6B.
Overall, Roseolovirus species are important human pathogens, particularly during early childhood, and may contribute to various clinical manifestations throughout life.
Human Herpesvirus 7 (HHV-7) is a species of the Herpesviridae family and Betaherpesvirinae subfamily. It is a double-stranded DNA virus that primarily infects human hosts. HHV-7 is closely related to Human Herpesvirus 6 (HHV-6) and both viruses share many biological and biochemical properties.
HHV-7 is typically acquired in early childhood, with most people becoming infected before the age of five. Primary infection with HHV-7 can cause a mild illness known as exanthema subitum or roseola infantum, which is characterized by fever and a rash. However, many HHV-7 infections are asymptomatic.
After initial infection, HHV-7 becomes latent in the host's immune cells, particularly CD4+ T-lymphocytes. The virus can reactivate later in life, causing various clinical manifestations such as chronic fatigue syndrome, seizures, and exacerbation of atopic dermatitis. HHV-7 has also been implicated in the development of certain malignancies, including lymphoproliferative disorders and some types of brain tumors.
Like other herpesviruses, HHV-7 establishes a lifelong infection in its human host, with periodic reactivation throughout the individual's lifetime.
Betaherpesvirinae is a subfamily of herpesviruses, which are a type of double-stranded DNA viruses. This subfamily includes human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7), as well as cytomegalovirus (CMV or HHV-5) in humans, and other species-specific betaherpesviruses in various animals.
These viruses are known to cause a range of clinical manifestations, from mild and self-limiting diseases to severe and life-threatening conditions, depending on the immune status of the host. For instance, primary infection with HHV-6 and HHV-7 typically occurs during early childhood and is usually asymptomatic or associated with a mild febrile illness, while reactivation of these viruses in immunocompromised individuals can lead to more severe complications.
Cytomegalovirus (CMV) infection can cause significant morbidity and mortality in newborns infected in utero, as well as in immunocompromised patients, such as those with HIV/AIDS or transplant recipients. CMV is also a leading cause of congenital hearing loss and developmental disabilities in children.
Betaherpesvirinae viruses are characterized by their ability to establish latency in host cells, where they can remain dormant for extended periods before reactivating under certain conditions, such as immunosuppression or stress. Effective antiviral therapies and vaccines are available for some betaherpesviruses, but there is still no cure for the viral infection, and lifelong latency is common.
Exanthema subitum is a medical term that is used to describe a specific type of rash-like skin eruption. It's also known as roseola infantum or sixth disease, which is a common viral illness that typically affects young children between the ages of 6 months and 2 years.
The term "exanthema" refers to a widespread eruption of skin lesions, while "subitum" means sudden. Therefore, exanthema subitum can be defined as a sudden onset of a rash that is typically caused by the human herpesvirus 6 (HHV-6) infection.
The rash associated with exanthema subitum usually appears after the child has had a few days of high fever, which can sometimes reach up to 105°F (40.5°C). The rash is typically made up of small, flat or raised pink or red spots that may be surrounded by a lighter halo. These spots can appear anywhere on the body but are most commonly found on the trunk, neck, and face.
While the rash itself is generally not harmful, it can be uncomfortable for the child, causing itching or irritation. In most cases, exanthema subitum resolves on its own within a few days to a week without any specific treatment. However, if your child has a high fever, is lethargic, or shows other signs of illness, you should contact your healthcare provider for further evaluation and guidance.
Human Herpesvirus 6 (HHV-6) is a species of the Roseolovirus genus in the Herpesviridae family. It is a double-stranded DNA virus and is one of the human herpesviruses, which are a group of viruses that includes eight different types that can infect humans.
There are two variants of HHV-6, known as HHV-6A and HHV-6B. Both variants are closely related but have distinct biological properties and clinical manifestations. HHV-6B is the cause of exanthem subitum (also known as roseola infantum or sixth disease), a common childhood illness characterized by fever and rash, while HHV-6A has been associated with various diseases in immunocompromised individuals, such as encephalitis, pneumonitis, and bone marrow suppression.
HHV-6 is highly prevalent in the human population, with most people getting infected during early childhood. After the initial infection, the virus remains latent in the body for the rest of a person's life, and it can reactivate under certain conditions, such as immune suppression or stress. Reactivation of HHV-6 has been associated with various diseases, including encephalitis, seizures, and fatigue.
It is important to note that while HHV-6 infection is common, most people do not develop any symptoms or long-term complications. However, in some cases, the virus can cause significant illness, especially in immunocompromised individuals.
An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.
Herpesvirus 1, also known as Ranid herpesvirus or Frog virus 3 (FV3), is not a human pathogen and does not have any medical relevance to humans. It is a virus that primarily infects amphibians, particularly frogs and toads.
Ranid herpesvirus belongs to the family Alloherpesviridae and is the type species of the genus Ranid herpesvirus. The virus is highly host-specific and has been found to cause fatal diseases in various ranid frog species, including the American bullfrog (Lithobates catesbeianus) and the green frog (Lithobates clamitans).
The virus typically infects the cells of the frog's immune system and can cause a range of symptoms, including lethargy, loss of appetite, skin lesions, and hemorrhage. In severe cases, it can lead to death. However, Ranid herpesvirus does not pose any threat to humans or other mammals.
Roseolovirus
List of MeSH codes (C02)
Herpes virus
Betaherpesvirinae
Roseola
Human herpesvirus 6
Human betaherpesvirus 7
Human betaherpesvirus 6B
Orthoherpesviridae
Herpesvirales
Cytomegalovirus
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Murine4
- HHV-6 increases risk of an "idiopathic" pneumonia syndrome after HCT as does murine roseolovirus in a BMT mouse model. (hhv-6foundation.org)
- A research team formed by members of Bethany Moore's Lung Immunology Lab and Gregory Yanik's BMT clinical team at the University of Michigan demonstrated that murine roseolovirus (MRV) is a useful homolog for the study of HHV-6 reactivation in lung disease post-hematopoietic cell transplantation (HCT). (hhv-6foundation.org)
- Following up on the work done by investigators at Washington University who characterized murine roseolovirus as a mouse homolog of HHV-6 and HHV-7 ( Patel 2017 ), Xiaofeng Zhou, PhD, infected newborn mice with MRV and later performed a bone marrow transplant (BMT) protocol after 8-10 weeks to reactivate the virus. (hhv-6foundation.org)
- Heterologous Immunity and Persistent Murine Cytomegalovirus Infection. (umassmed.edu)
Genus3
- Roseolovirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Betaherpesvirinae. (wikipedia.org)
- The genus consists of the following six species: Human betaherpesvirus 7 Human betaherpesvirus 6A Human betaherpesvirus 6B Macacine betaherpesvirus 9 Murid betaherpesvirus 3 Suid betaherpesvirus 2 Viruses in Roseolovirus are enveloped, with icosahedral, spherical to pleomorphic, and round geometries, and T=16 symmetry. (wikipedia.org)
- A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, causing infection involving several organs in mice and rats. (umassmed.edu)
Herpesvirus4
- HHV-6 was the sixth herpesvirus discovered, and infection in humans is nearly ubiquitous in the first two years of life, with seroprevalence rates surpassing 95% in most studies. (medscape.com)
- There is growing evidence that host cells try to control Herpesvirus infections by activating the autophagic machinery. (mdpi.com)
- Inflammation of brain tissue caused by infection with the varicella-zoster virus (HERPESVIRUS 3, HUMAN). (wakehealth.edu)
- Quantification of two viral transcripts by real time PCR to investigate human herpesvirus type 6 active infection. (biopticka.cz)
Viral infection3
- Herpes labialis, commonly known as cold sores, is a viral infection caused by the herpes simplex virus (HSV). (labialisherpes.com)
- 242 or 32% of the HCT patients studied had a viral infection and overall survival was significantly lower in patients with an infection, compared to those without. (hhv-6foundation.org)
- 40% mortality following viral infection. (what-when-how.com)
Viruses1
- Attrition of T cell memory: selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses. (umassmed.edu)
Rash1
- Such infections usually cause fever, with exanthem subitum ( Roseola /rash) [1] only being observed in 10% of cases. (wikidoc.org)
Primary infection3
- The primary infection of HHV-6 frequently occurs as a vague illness with a fairly high fever, sometimes accompanied by convulsions. (biopticka.cz)
- After primary infection, latency is established in myeloid and bone marrow progenitors and exists for the life time of the host. (wikidoc.org)
- First you get a primary infection, with red blisters and an itching or burning as I play with your nerves. (blogspot.com)
Acute3
- [ 8 ] Acute HHV-6 infection is rare in immunocompetent adults but may manifest as a mononucleosislike illness characterized by fever, lymphadenopathy, and hepatitis . (medscape.com)
- COVID-19 survivors often suffer from post-acute sequelae of SARS-CoV-2 infection (PASC). (bvsalud.org)
- NK cells controlling virus-specific T cells: Rheostats for acute vs. persistent infections. (umassmed.edu)
Induces2
- Infection increases ROS, induces ER stress and activates STAT3, NF-κB and mTOR pathways. (hhv-6foundation.org)
- HHV-6 also contributes to immune suppression caused by HIV co-infection and induces the production of cytokines. (biopticka.cz)
Encephalitis4
- Although rare, this initial infection can also cause febrile seizures, encephalitis or intractable seizures. (wikipedia.org)
- Infection is typically self-limited in children, but HHV-6 encephalitis can occur in immunocompromised patients and is the most feared complication of HHV-6 disease. (medscape.com)
- It presents again as a febrile illness, but also encephalitis, pneumonia, hepatitis and symptoms of bone marrow suppression and deterioration of a CMV infection. (biopticka.cz)
- HHV-6 primary infections account for up to 20% of infant hospitalizations in the United States and are associated with several more severe complications, such as encephalitis , lymphadenopathy , myocarditis and myelosuppression . (wikidoc.org)
Supportive1
- [ 2 ] Management of HHV-6 infection in immunocompetent hosts is supportive. (medscape.com)
Fever2
- Primary HHV-6 infection usually occurs in infants or children and is a common cause of fever-induced seizures in children aged 6-24 months. (medscape.com)
- In older infants and toddlers up to one-fifth of the fever is of a roseolovirus origin. (biopticka.cz)
Initial infection1
- Similar to other herpesviruses, HHV-6 infects a wide variety of cells and remains latent after initial infection. (medscape.com)
Herpesviruses1
- [ 6 ] Unlike other herpesviruses, HHV-6 has the ability to be chromosomally integrated, which, while occurring in less than 1% of the total population who newly acquire infection, is the suggested route of vertical transmission. (medscape.com)
Adults1
- Although up to 100% of the population are exposed (seropositive) to HHV-6, most by 3 years of age, there are rare cases of primary infections in adults. (wikidoc.org)
Mortality1
- Early "first" HHV-6 infection was associated with a highly significant increase in non-relapse mortality in a retrospective study of 738 HCT patients. (hhv-6foundation.org)
Chronic1
- Since HHV-6A and HHV-6B can smolder in the brain and other organs without circulating in the peripheral blood or plasma, identifying chronic infection is a challenge. (hhv-6foundation.org)
Mice2
- Most of the pre-infected BMT mice developed active MRV infections in their lungs by 2 weeks after mismatched transplant, and histological examination 6 weeks after transplant found the MRV infected mice to show features consistent with IPS. (hhv-6foundation.org)
- Of interest, the mice had little or no viral DNA in their BAL fluid by 8 weeks post BMT, which, the authors point out, is consistent with an "occult" infection being missed in patients with IPS. (hhv-6foundation.org)
Cells1
- A subset of ADI cells shows nuclear accumulation of TP53 at 6- and 14-days post infection (dpi), indicating a prolonged arrest in the ADI state. (bvsalud.org)
Common1
- [32] Subclinical ( asymptomatic ) infections with variola virus were noted but were not common. (alquds.edu)
Risk2
- Multivariable analysis showed that first onset infection with HHV-6, EBV and HSV resulted in a 5.5, 9.2 and 11 fold increased risk of IPS, respectively. (hhv-6foundation.org)
- First infection with CMV increased the risk of bronchiolitis obliterans syndrome, by almost three-fold. (hhv-6foundation.org)
Current1
- Less known is Pasteur\'s vision on infection prevention and control (IPC) that drove current infection control, public health, and much of modern medicine and surgery. (journalfilter.com)
Control1
- lt;h4>Innovation for infection prevention and control-revisiting Pasteur\'s vision. (journalfilter.com)
Cell2
- Could some complications of CAR-T cell therapy be secondary to HHV-6 infection? (hhv-6foundation.org)
- HHV-6 infection has been associated with complications of varying severity in hematopoietic stem cell transplant (HSCT) recipients, to a lesser degree in solid organ transplant (SOT) recipients, and in those who are otherwise immunosuppressed. (medscape.com)
Exist1
- [ 11 ] Methods to differentiate true infection from ciHHV-6 exist but are often not readily available clinically. (medscape.com)
Years1
- [ 1 ] Infection is nearly ubiquitous by age 2 years. (medscape.com)