A water-soluble polypeptide (molecular weight approximately 8,000) extractable from the corpus luteum of pregnancy. It produces relaxation of the pubic symphysis and dilation of the uterine cervix in certain animal species. Its role in the human pregnant female is uncertain. (Dorland, 28th ed)
Cell surface receptors that bind peptide messengers with high affinity and regulate intracellular signals which influence the behavior of cells.
A slightly movable cartilaginous joint which occurs between the pubic bones.
The largest family of cell surface receptors involved in SIGNAL TRANSDUCTION. They share a common structure and signal through HETEROTRIMERIC G-PROTEINS.
A type of CARTILAGE whose matrix contains large bundles of COLLAGEN TYPE I. Fibrocartilage is typically found in the INTERVERTEBRAL DISK; PUBIC SYMPHYSIS; TIBIAL MENISCI; and articular disks in synovial JOINTS. (From Ross et. al., Histology, 3rd ed., p132,136)
The yellow body derived from the ruptured OVARIAN FOLLICLE after OVULATION. The process of corpus luteum formation, LUTEINIZATION, is regulated by LUTEINIZING HORMONE.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
The process of bearing developing young (EMBRYOS or FETUSES) in utero in non-human mammals, beginning from FERTILIZATION to BIRTH.

Relaxin is a potent renal vasodilator in conscious rats. (1/449)

The kidneys and other nonreproductive organs vasodilate during early gestation; however, the "pregnancy hormones" responsible for the profound vasodilation of the renal circulation during pregnancy are unknown. We hypothesized that the ovarian hormone relaxin (RLX) contributes. Therefore, we tested whether the administration of RLX elicits renal vasodilation and hyperfiltration in conscious adult, intact female rats. After several days of treatment with either purified porcine RLX or recombinant human RLX 2 (rhRLX), effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) increased by 20%-40%. Comparable renal vasodilation and hyperfiltration was also observed in ovariectomized rats, suggesting that estrogen and progesterone are unnecessary for the renal response to rhRLX. The nitric oxide synthase inhibitor Nomega-nitro-L-arginine methyl ester completely abrogated the increase in ERPF and GFR elicited by chronic administration of purified porcine RLX. In contrast, the renal vasoconstrictory response to angiotensin II was attenuated by the RLX treatment. Short-term infusion of purified porcine RLX to conscious rats over several hours failed to increase ERPF and GFR. Plasma osmolality was consistently reduced by the chronic administration of both RLX preparations. In conclusion, the renal and osmoregulatory effects of chronic RLX administration to conscious rats resemble the physiological changes of pregnancy in several respects: (a) marked increases in ERPF and GFR with a mediatory role for nitric oxide; (b) attenuation of the renal circulatory response to angiotensin II; and (c) reduction in plasma osmolality.  (+info)

Canine preprorelaxin: nucleic acid sequence and localization within the canine placenta. (2/449)

Employing uteroplacental tissue at Day 35 of gestation, we determined the nucleic acid sequence of canine preprorelaxin using reverse transcription- and rapid amplification of cDNA ends-polymerase chain reaction. Canine preprorelaxin cDNA consisted of 534 base pairs encoding a protein of 177 amino acids with a signal peptide of 25 amino acids (aa), a B domain of 35 aa, a C domain of 93 aa, and an A domain of 24 aa. The putative receptor binding region in the N'-terminal part of the canine relaxin B domain GRDYVR contained two substitutions from the classical motif (E-->D and L-->Y). Canine preprorelaxin shared highest homology with porcine and equine preprorelaxin. Northern analysis revealed a 1-kilobase transcript present in total RNA of canine uteroplacental tissue but not of kidney tissue. Uteroplacental tissue from two bitches each at Days 30 and 35 of gestation were studied by in situ hybridization to localize relaxin mRNA. Immunohistochemistry for relaxin, cytokeratin, vimentin, and von Willebrand factor was performed on uteroplacental tissue at Day 30 of gestation. The basal cell layer at the core of the chorionic villi was devoid of relaxin mRNA and immunoreactive relaxin or vimentin but was immunopositive for cytokeratin and identified as cytotrophoblast cells. The cell layer surrounding the chorionic villi displayed specific hybridization signals for relaxin mRNA and immunoreactivity for relaxin and cytokeratin but not for vimentin, and was identified as syncytiotrophoblast. Those areas of the chorioallantoic tissue with most intense relaxin immunoreactivity were highly vascularized as demonstrated by immunoreactive von Willebrand factor expressed on vascular endothelium. The uterine glands and nonplacental uterine areas of the canine zonary girdle placenta were devoid of relaxin mRNA and relaxin. We conclude that the syncytiotrophoblast is the source of relaxin in the canine placenta.  (+info)

Endocrine biomarkers of early fetal loss in cynomolgus macaques (Macaca fascicularis) following exposure to dioxin. (3/449)

This study examines the endocrine alterations associated with early fetal loss (EFL) induced by an environmental toxin, TCDD (2,3,7, 8-tetrachlorodibenzo-p-dioxin), in the cynomolgus macaque, a well-documented reproductive/developmental model for humans. Females were administered single doses of 1, 2, and 4 microgram/kg TCDD (n = 4 per dose group) on gestational day (GD) 12. Urinary estrogen metabolites (estrone conjugates) were monitored to establish the day of ovulation, and serum hormones (estradiol, progesterone, chorionic gonadotropin, relaxin) were measured to assess ovarian and placental endocrine status before and after treatment. EFL occurred between GDs 22 and 32 in 10 of the 12 animals treated with TCDD. The primary endocrine alterations associated with TCDD treatment were significant decreases in serum estradiol and bioactive chorionic gonadotropin concentrations (p < 0.02). Less pronounced decreases in serum progesterone (p = 0.10) and relaxin (p < 0.08) also followed TCDD treatment. In contrast, immunoreactive chorionic gonadotropin concentrations were not reduced by TCDD exposure at any level, indicating that TCDD targets specific components of the chorionic gonadotropin synthesis machinery within the trophoblast to alter the functional capacity of the hormone. These data demonstrate the value of endocrine biomarkers in identifying a toxic exposure to primate pregnancy many days before direct signs of reproductive toxicity were apparent. The increased EFL that occurred after exposure to TCDD might reflect a toxic response initially mediated via endocrine imbalance, leading to placental insufficiency, compromised embryonic circulation, and subsequent EFL.  (+info)

Relaxin secretion by human granulosa cell culture is predictive of in-vitro fertilization-embryo transfer success. (4/449)

We have developed a cell culture system for human luteinizing granulosa cells which supports the timely and dynamic secretion of oestrogen, progesterone and relaxin in patterns that mimic serum concentrations of these hormones during the luteal phase of the menstrual cycle. There was a wide variation in the amount of relaxin secreted by the cultured cells for the 69 patients studied. As relaxin production was generally maximal by day 10 of culture, comparisons were made at this time point. It was observed that most of the conceptions occurred in patients with higher relaxin secretion in vitro. All cycles with relaxin > 800 pg/ml on day 10 had a term pregnancy while only 13% of cycles with relaxin < 200 pg/ml had term pregnancies. A limited number of cycles from donor/recipient cycles did not show similar results. Steroid concentrations were not predictive of conception. These results demonstrated that in-vitro production of relaxin is predictive of implantation success in in-vitro fertilization (IVF)-embryo transfer cycles. This supports the hypothesis that relaxin may be involved in implantation and that lowered relaxin concentrations may be a partial cause of poor pregnancy rates after IVF.  (+info)

Relaxin stimulates expression of vascular endothelial growth factor in normal human endometrial cells in vitro and is associated with menometrorrhagia in women. (5/449)

Although the role of the reproductive hormone, relaxin, in rodents is well documented, its potential contribution to human reproduction is less well defined. In this study, we examine the effects of relaxin on human endometrial cells in vitro and describe the clinical effects of relaxin on menstrual flow in women. In cultured endometrial cells, relaxin specifically induces the expression of an angiogenic agent, vascular endothelial growth factor (VEGF). cAMP is implicated as a second messenger involved in VEGF stimulation. VEGF expression is temporally regulated in the endometrium, and our results suggest that relaxin, which is secreted by the corpus luteum and is present in the endometrium during the menstrual cycle and pregnancy, may be involved in regulating endometrial VEGF expression. Relaxin was recently tested in a clinical trial for efficacy in the treatment of progressive systemic sclerosis, and was administered at levels up to 10 times higher than that measured during pregnancy. The most frequent relaxin-related adverse event reported during the course of the study was the onset of menometrorrhagia, defined in this study as heavier-than-usual or irregular menstrual bleeding. The intensification of menstrual flow observed in these patients is consistent with the hypothesis that relaxin mediates neovascularization of the endometrial lining.  (+info)

Relaxin stimulates glycodelin mRNA and protein concentrations in human endometrial glandular epithelial cells. (6/449)

Human endometrium is the major organ that produces glycodelin A (GdA). The production of endometrial GdA causes a fluctuation of the peripheral glycodelin concentrations in women during the menstrual cycle and pregnancy. It has recently been reported that the rise of plasma concentrations of glycodelin is correlated with relaxin during the late luteal phase and early pregnancy. In addition, administration of relaxin increases glycodelin plasma concentrations, suggesting that relaxin induces GdA production in endometrium. To investigate whether relaxin regulates the GdA synthesis, human endometrial glandular epithelial cells were isolated and cultured with or without relaxin for up to 4 days. Western blot showed that GdA synthesized and secreted from epithelial glands had a major molecular weight of 28 kDa, i.e. the same as the GdA isolated from amniotic fluid. Cells incubated with relaxin consistently increased in GdA production rate (2-6-fold). The GdA mRNA concentrations increased 2-11-fold in cells incubated with relaxin for 2-4 days, as determined by solution hybridization/ribonuclease protection assay. The increase of the mRNA concentration indicates that relaxin activates GdA transcription.  (+info)

What knockout mice can tell us about parturition. (7/449)

Many molecules, including steroid and peptide hormones, prostaglandins and cytokines, regulate the preparation, initiation and progression of parturition in mammals. Gene targeting studies show that, in the knockout mice of steroid 5alpha-reductase type 1 gene, prostaglandin F2alpha receptor gene and cytosolic phospholipase A2 gene, parturition was severely disturbed, although live offspring were delivered by Caesarean section. Relaxin gene-disrupted mice also showed protracted labour. However, most knockout mice in which the steroid hormone, prostaglandin, cytokine or peptide hormone (for example, oxytocin, corticotrophin releasing hormone and endothelin) endocrine-paracrine systems are disrupted are inadequate for analysis of the mechanism of parturition because they die before reaching reproductive age or are infertile, or because they reproduce normally. A conditional knockout strategy, for example, using the Cre-LoxP system, should be considered for investigating the biochemical background of parturition to overcome these problems.  (+info)

Quantitative autoradiographic studies of relaxin binding in rat atria, uterus and cerebral cortex: characterization and effects of oestrogen treatment. (8/449)

The binding characteristics of the relaxin receptor in rat atria, uterus and cortex were studied using a [33P]-labelled human gene 2 relaxin (B33) and quantitative receptor autoradiography. The binding kinetics of [33P]-human gene 2 relaxin (B33) were investigated in slide-mounted rat atrial sections. The binding achieved equilibrium after 60 min incubation at room temperature (23+/-1 degrees C) and dissociated slowly. The association and dissociation rate constants were 4.31+/-0.34x10(8) M(-1) x min(-1) and 1.55+/-0.38x10(-3) min(-1) respectively. Thus, the kinetic dissociation constant was 3.46+/-0.59 pM. Binding was saturable to a single population of non-interacting sites throughout atria, in uterine myometrium and the 5th layer of cerebral cortex. The binding affinities (pK(D)) of [33P]-human gene 2 relaxin (B33) were 8.92+/-0.09 in atrial myocardium and 8.79+/-0.04 in cerebral cortex of male rats, and 8.79+/-0.10 in uterine myometrium. Receptor densities in the cerebral cortex and atria were higher than in uterine myometrium, indicating that relaxin also has important roles in non-reproductive tissues. In male rats, treatment with 17beta-oestradiol (20 microg in 0.1 ml sesame oil s.c., 18-24 h) significantly decreased the density of relaxin receptors in atria and cerebral cortex. Identical treatment in female rats had no significant effect in atria and cerebral cortex, but it significantly increased the density of relaxin receptors in uterine myometrium. Relaxin binding was competitively displaced by porcine and rat native relaxins. Porcine native relaxin binds to the relaxin receptor in male rat atria (8.90+/-0.02), and cerebral cortex (8.90+/-0.03) and uterine myometrium (8.89+/-0.03) with affinities not significantly different from human gene 2 (B33) relaxin. Nevertheless, rat relaxin binds to the receptors with affinities (8.35+/-0.09 in atria, 8.22+/-0.07 in cerebral cortex and 8.48+/-0.06 in uterine myometrium) significantly less than human gene 2 (B33) and porcine relaxins. Quantitative receptor autoradiography is the method of choice for measurement of affinities and densities of relaxin receptor in atria, uterine myometrium and cerebral cortex. High densities were found in all these tissues. 17beta-oestradiol treatment produced complex effects where it increased the densities of relaxin receptors in uterus but decreased those in atria and cerebral cortex of the male rats, and had no effect on the atria and cerebral cortex of the female rats.  (+info)

Relaxin is a hormone produced by the ovaries and, during pregnancy, also by the placenta and the fetal membranes. Its primary function is to relax the uterus and pelvic joints in preparation for childbirth, hence its name. It does this by softening the connective tissues and increasing their elasticity, which allows them to stretch more easily. Relaxin also plays a role in the cardiovascular system during pregnancy, helping to maintain healthy blood pressure levels.

Additionally, relaxin has been shown to have effects on other parts of the body, such as reducing muscle stiffness and joint pain, increasing flexibility, and potentially even playing a role in bone metabolism. However, more research is needed to fully understand all of its functions and potential therapeutic uses.

Peptide receptors are a type of cell surface receptor that bind to peptide hormones and neurotransmitters. These receptors play crucial roles in various physiological processes, including regulation of appetite, pain perception, immune function, and cardiovascular homeostasis. Peptide receptors belong to the G protein-coupled receptor (GPCR) superfamily or the tyrosine kinase receptor family. Upon binding of a peptide ligand, these receptors activate intracellular signaling cascades that ultimately lead to changes in cell behavior and communication with other cells.

Peptide receptors can be classified into two main categories: metabotropic and ionotropic. Metabotropic peptide receptors are GPCRs, which activate intracellular signaling pathways through coupling with heterotrimeric G proteins. These receptors typically have seven transmembrane domains and undergo conformational changes upon ligand binding, leading to the activation of downstream effectors such as adenylyl cyclase, phospholipase C, or ion channels.

Ionotropic peptide receptors are ligand-gated ion channels that directly modulate ion fluxes across the cell membrane upon ligand binding. These receptors contain four or five subunits arranged around a central pore and undergo conformational changes to allow ion flow through the channel.

Examples of peptide receptors include:

1. Opioid receptors (μ, δ, κ) - bind endogenous opioid peptides such as enkephalins, endorphins, and dynorphins to modulate pain perception and reward processing.
2. Somatostatin receptors (SSTR1-5) - bind somatostatin and cortistatin to regulate hormone secretion, cell proliferation, and angiogenesis.
3. Neuropeptide Y receptors (Y1-Y5) - bind neuropeptide Y to modulate feeding behavior, energy metabolism, and cardiovascular function.
4. Calcitonin gene-related peptide receptor (CGRP-R) - binds calcitonin gene-related peptide to mediate vasodilation and neurogenic inflammation.
5. Bradykinin B2 receptor (B2R) - binds bradykinin to induce pain, inflammation, and vasodilation.
6. Vasoactive intestinal polypeptide receptors (VPAC1, VPAC2) - bind vasoactive intestinal peptide to regulate neurotransmission, hormone secretion, and smooth muscle contraction.
7. Oxytocin receptor (OXTR) - binds oxytocin to mediate social bonding, maternal behavior, and uterine contractions during childbirth.
8. Angiotensin II type 1 receptor (AT1R) - binds angiotensin II to regulate blood pressure, fluid balance, and cell growth.

The pubic symphysis is the joint in the front of the pelvis that connects the two halves of the pelvic girdle, specifically the pubic bones. It's located at the lower part of the anterior (front) pelvic region. Unlike most joints, which are movable and contain synovial fluid, the pubic symphysis is a cartilaginous joint, also known as an amphiarthrosis.

The joint consists of fibrocartilaginous discs, ligaments, and the articular surfaces of the adjacent pubic bones. The fibrocartilaginous disc helps to absorb shock and reduce friction between the two bones. The main function of the pubic symphysis is to provide stability for the pelvis and transfer weight and forces from the upper body to the lower limbs during activities like walking, running, or jumping.

The pubic symphysis has a limited range of motion, allowing only slight movement in response to pressure or tension. During pregnancy and childbirth, the hormone relaxin is released, which increases the laxity of the pelvic joints, including the pubic symphysis, to accommodate the growing fetus and facilitate delivery. This increased mobility can sometimes lead to discomfort or pain in the area, known as symphysis pubis dysfunction (SPD) or pelvic girdle pain.

G-protein-coupled receptors (GPCRs) are a family of membrane receptors that play an essential role in cellular signaling and communication. These receptors possess seven transmembrane domains, forming a structure that spans the lipid bilayer of the cell membrane. They are called "G-protein-coupled" because they interact with heterotrimeric G proteins upon activation, which in turn modulate various downstream signaling pathways.

When an extracellular ligand binds to a GPCR, it causes a conformational change in the receptor's structure, leading to the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP) on the associated G protein's α subunit. This exchange triggers the dissociation of the G protein into its α and βγ subunits, which then interact with various effector proteins to elicit cellular responses.

There are four main families of GPCRs, classified based on their sequence similarities and downstream signaling pathways:

1. Gq-coupled receptors: These receptors activate phospholipase C (PLC), which leads to the production of inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 induces calcium release from intracellular stores, while DAG activates protein kinase C (PKC).
2. Gs-coupled receptors: These receptors activate adenylyl cyclase, which increases the production of cyclic adenosine monophosphate (cAMP) and subsequently activates protein kinase A (PKA).
3. Gi/o-coupled receptors: These receptors inhibit adenylyl cyclase, reducing cAMP levels and modulating PKA activity. Additionally, they can activate ion channels or regulate other signaling pathways through the βγ subunits.
4. G12/13-coupled receptors: These receptors primarily activate RhoGEFs, which in turn activate RhoA and modulate cytoskeletal organization and cellular motility.

GPCRs are involved in various physiological processes, including neurotransmission, hormone signaling, immune response, and sensory perception. Dysregulation of GPCR function has been implicated in numerous diseases, making them attractive targets for drug development.

Fibrocartilage is a type of tough, dense connective tissue that contains both collagen fibers and cartilaginous matrix. It is composed of fibroblasts embedded in a extracellular matrix rich in collagen types I and II, proteoglycans and elastin. Fibrocartilage is found in areas of the body where strong, flexible support is required, such as intervertebral discs, menisci (knee cartilage), labrum (shoulder and hip cartilage) and pubic symphysis. It has both the elasticity and flexibility of cartilage and the strength and durability of fibrous tissue. Fibrocartilage can withstand high compressive loads and provides cushioning, shock absorption and stability to the joints and spine.

The corpus luteum is a temporary endocrine structure that forms in the ovary after an oocyte (egg) has been released from a follicle during ovulation. It's formed by the remaining cells of the ruptured follicle, which transform into large, hormone-secreting cells.

The primary function of the corpus luteum is to produce progesterone and, to a lesser extent, estrogen during the menstrual cycle or pregnancy. Progesterone plays a crucial role in preparing the uterus for potential implantation of a fertilized egg and maintaining the early stages of pregnancy. If pregnancy does not occur, the corpus luteum will typically degenerate and stop producing hormones after approximately 10-14 days, leading to menstruation.

However, if pregnancy occurs, the developing embryo starts to produce human chorionic gonadotropin (hCG), which signals the corpus luteum to continue secreting progesterone and estrogen until the placenta takes over hormonal production, usually around the end of the first trimester.

Pregnancy is a physiological state or condition where a fertilized egg (zygote) successfully implants and grows in the uterus of a woman, leading to the development of an embryo and finally a fetus. This process typically spans approximately 40 weeks, divided into three trimesters, and culminates in childbirth. Throughout this period, numerous hormonal and physical changes occur to support the growing offspring, including uterine enlargement, breast development, and various maternal adaptations to ensure the fetus's optimal growth and well-being.

"Animal pregnancy" is not a term that is typically used in medical definitions. However, in biological terms, animal pregnancy refers to the condition where a fertilized egg (or eggs) implants and develops inside the reproductive tract of a female animal, leading to the birth of offspring (live young).

The specific details of animal pregnancy can vary widely between different species, with some animals exhibiting phenomena such as placental development, gestation periods, and hormonal changes that are similar to human pregnancy, while others may have very different reproductive strategies.

It's worth noting that the study of animal pregnancy and reproduction is an important area of biological research, as it can provide insights into fundamental mechanisms of embryonic development, genetics, and evolution.

... family peptide hormones Insulin/IGF/Relaxin family Relaxin/insulin-like family peptide receptor 1 Bani D (January 1997 ... Relaxin 1 and relaxin 2 arose from the duplication of a proto-RLN gene between 44.2 and 29.6 million years ago in the last ... In females, relaxin is produced mainly by the corpus luteum, in both pregnant and nonpregnant females. Relaxin levels rise to a ... Relaxin is a protein hormone of about 6000 Da, first described in 1926 by Frederick Hisaw. The relaxin family peptide hormones ...
Relaxin family peptide hormones Insulin/IGF/Relaxin family Relaxin Relaxin/insulin-like family peptide receptor 1 Bathgate, ... Relaxin-3 is a member and ancestral gene of the relaxin family of peptides, which includes the namesake hormone relaxin ( ... The cognate receptor for relaxin-3 is the G-protein coupled receptor RXFP3 (relaxin family peptide 3 receptor), however relaxin ... "Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family". The Journal ...
Relaxin family peptide hormones Insulin/IGF/Relaxin family Relaxin/insulin-like family peptide receptor 1 Bathgate RA, Ivell R ... The relaxin receptors are a subclass of four closely related G protein-coupled receptors (GPCR) that bind relaxin peptide ... relaxin+receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with short ... "Relaxin Family Peptide Receptors: Motilin". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and ...
... (1969) is a compilation by Chet Atkins. Side 1: "Blues for Dr. Joe" "Sophisticated Lady" "Yesterdays" "Say ...
"Relaxin' at Camarillo" is a composition by jazz saxophonist Charlie Parker. It is inspired by his six-month stay in Camarillo ... The title "Relaxin' at Camarillo" was a reference to Parker's stay in Camarillo State Hospital in Ventura County, California, a ... Jazz Journal International stated in 2009 that Walton "provides a stimulating introduction to Parker's Relaxin' At Camarillo. ... ISBN 978-0-19-992430-1. "Relaxin' at Camarillo". Learn Jazz Standards. 5 September 2012. Retrieved 14 March 2017. Gioia, Ted ( ...
Relaxin' at Camarillo is an album by American jazz saxophonist Joe Henderson, recorded in 1979 and released on the Contemporary ... Relaxin' at Camarillo - Review at AllMusic. Retrieved May 6, 2015. Swenson, J., ed. (1985). The Rolling Stone Jazz Record Guide ... "Relaxin' at Camarillo" (Charlie Parker) - 9:21 Joe Henderson - tenor saxophone Chick Corea - piano Richard Davis (tracks 3 & 4 ...
Relaxin Relaxin receptor Relaxin/insulin-like family peptide receptor 1 Sherwood OD (April 2004). "Relaxin's physiological ... Relaxin family peptide hormones in humans are represented by seven members: three relaxin-like (RLN) and four insulin-like ( ... Multiple relaxin genes have also been identified in Amphioxus, but again syntenic relationship of these genes to modern relaxin ... Mita M (January 2013). "Relaxin-like gonad-stimulating substance in an echinoderm, the starfish: a novel relaxin system in ...
"Relaxo finds the right fit, closes in on Bata's m-cap". Economic Times. Retrieved 10 May 2020. "Relaxo eyes Rs 2,500 crore ... "Relaxo, On Strong Footing". Forbes India. Retrieved 7 December 2021. "Relaxo Footwears Q4 net profit falls 38% to Rs 63 cr; ... "Relaxo changes its 40-year old logo; aims to open 10 franchise stores this year". Livemint. Retrieved 10 May 2020. "Relaxo: ... "Relaxo in retail push to grow topline". Moneycontrol. Retrieved 10 May 2020. "11,800% jump in 10 years! This stock remains ...
... is a moth in the family Geometridae. It is found in Colombia. Yu, Dicky Sick Ki. "Eois relaxaria (Snellen 1874 ...
... is a tussock-forming species of perennial sedge in the family Cyperaceae. It is native to parts of Siberia and ... List of Carex species "Carex relaxa V.I.Krecz". Kew Science - Plants of the World Online. Retrieved 28 April 2023. v t e (Use ...
A muscle relaxant is a drug that affects skeletal muscle function and decreases the muscle tone. It may be used to alleviate ... A muscle relaxant is chosen based on its adverse-effect profile, tolerability, and cost. Muscle relaxants (according to one ... "muscle relaxant Archived 2013-10-06 at the Wayback Machine." mediLexicon Archived 2013-10-06 at the Wayback Machine. (c) 2007. ... The term "muscle relaxant" is used to refer to two major therapeutic groups: neuromuscular blockers and spasmolytics. ...
... is an album by the Miles Davis quintet recorded in 1956 and released in March 1958. Two ... "Miles Davis - Relaxin' with the Miles Davis Quintet". AllMusic. Retrieved October 28, 2016. Larkin, Colin (2007). The ...
... is one of his best latter period efforts". "I'll Never Be The Same" (Gus Kahn, Matty Malneck, Frank Signorelli ... The Hawk Relaxes is an album by saxophonist Coleman Hawkins which was recorded in 1961 and released on the Moodsville label. ...
... (SRBAs) are a new class of drugs that selectively encapsulates and binds neuromuscular ...
It was released on April 14, 2004 by Relax-In and Megastar Records. This was the follow-up project to 2003's Ya Salam. In 2003 ... Nancy Ajram (2004). Ah W Noss (Media notes). Relax-In/Megastar. 7243 576650 2 5. "Nancy Nabil Ajram". Welcome Qatar. "شكوى من ...
Relax-in/Megastar. 2003.{{cite AV media notes}}: CS1 maint: others in cite AV media (notes) (link) Ah W Noss (inlay cover). ... Relax-in/Megastar. 2004.{{cite AV media notes}}: CS1 maint: others in cite AV media (notes) (link) Ya Tabtab...Wa Dallaa (inlay ...
It was released on February 24, 2003 by Relax-In and Megastar. Ajram worked with all new collaborations, including Tarek ... Relax-In/Megastar. 07243 581682 2 8.Ya Salam "Lebanese pop singer Nancy Ajram displays her trophy". Getty Images. "جائزة "أصغر ...
"G-Side (2) - Relaxin'". Discogs. Retrieved 2019-06-05. Galil, Leor. "Milwaukee Rapper Juiceboxxx Takes His Brand to the Thunder ... Juiceboxxx founded the Thunder Zone Entertainment label in 2011, releasing a seven-inch vinyl single, "Relaxin'," by G-Side ...
... and the Relaxin hormone. Previously known as the Howard Florey Institute of Experimental Physiology and Medicine, in 1997 the ...
"The role of the hormone Relaxin on human reproduction" which is the title of his MD thesis (University of Glasgow, awarded 1985 ... Progress in Relaxin Research. Singapore: Global Publications. ISBN 978-9-813049-02-4. MacLennan AH; Sturdee DW (2008). The ...
"POTION 2: Relaxin' with Final Fantasy: Review by Scherzo". Square Enix Music Online. Archived from the original on 2012-02-08. ... POTION~Relaxin' with FINAL FANTASY~ (in Japanese). Oricon. Archived from the original on 2012-10-22. Retrieved 2010-06-24. ... "Potion: Relaxin' with Final Fantasy". RPGFan. Archived from the original on 2013-01-16. Retrieved 2008-04-22. Greening, Chris ... "Potion 2: Relaxin' with Final Fantasy". RPGFan. Archived from the original on 2013-01-16. Retrieved 2008-04-22. Philip. " ...
Ridley, Ian (31 May 1989). "Mackay's relaxant". The Guardian. p. 18. Archived from the original on 18 January 2021. Retrieved ...
"Mackay's relaxant". The Guardian. 31 May 1989. Archived from the original on 18 January 2021. Retrieved 3 June 2021 - via ...
"FETCH! with Ruff Ruffman" Relaxin' with Ruff". IMDB. Retrieved August 28, 2021. ""Zoom" Episode #6.3 (TV Episode 2004) - ...
"Relaxin and its role in pregnancy". Endocrinology and metabolism clinics of North America. 24 (1). ISSN 0889-8529. PMID 7781625 ...
"Music Review: Lolina - Relaxin' with LOLINA". Tiny Mix Tapes. Retrieved 2021-09-04. "Lolina - Live In Paris · Album Review ⟋ RA ... Relaxin' with Lolina (EP) (2015) Live In Paris (LP) (2016) Lolita (EP) (2017) The Smoke (LP) (2018) Live in Geneva (LP) (2019) ...
Relaxin binding to endothelial B receptor on endothelial cells also induces vasodilation. Relaxin causes vasodilation by an ... Relaxin also functions as a cardiac stimulant. Studies have demonstrated that relaxin increases calcium sensitivity of cardiac ... Thus relaxin and serelaxin can increase stroke volume, the amount of blood pumped per heart beat, without increasing the energy ... Relaxin can also bind to a secondary receptor, endothelial B receptor,[clarification needed] which is upregulated as a result ...
The FDA informed owners of Relax-A-Cizors that second-hand sale of Relax-A-Cizors was illegal, and recommended that they should ... The Relax-A-Cizor was one brand of device manufactured by the U.S. company Relaxacizor, Inc. From the 1950s, the company ... Relax-A-Cizors had from 1 to 6 channels. Two pads (or electrodes) were connected by wires to each channel. The user applied ... The case went to court, and the United States District Court for the Central District of California held that the Relax-A-Cizor ...
Succinylcholine is a widely used muscle relaxant drug which acts by activating, instead of blocking, the ACh receptor. The ... Thompson MA (February 1980). "Muscle relaxant drugs". British Journal of Hospital Medicine. 23 (2): 153-4, 163-4, 167-8 passim ...
Agencies (22 April 2020). "Kano relaxes lockdown for one day". TODAY. Retrieved 9 January 2021. Kano, Ibrahim Musa Giginyu (10 ... "Kano relaxes lockdown". The Sun Nigeria. 23 April 2020. Retrieved 3 March 2022. https://gawuna.org/[dead link] "Kano Assembly ...
Relaxin family peptide hormones Insulin/IGF/Relaxin family Relaxin/insulin-like family peptide receptor 1 Bani D (January 1997 ... Relaxin 1 and relaxin 2 arose from the duplication of a proto-RLN gene between 44.2 and 29.6 million years ago in the last ... In females, relaxin is produced mainly by the corpus luteum, in both pregnant and nonpregnant females. Relaxin levels rise to a ... Relaxin is a protein hormone of about 6000 Da, first described in 1926 by Frederick Hisaw. The relaxin family peptide hormones ...
See releases by Relaxin Records
Cyranoski, D. Japan relaxes human stem-cell rules. Nature 460, 1068 (2009). https://doi.org/10.1038/4601068a ...
https://CRAN.R-project.org/package=relaxo. to link to this page. ... Package relaxo was removed from the CRAN repository.. ...
NHS medicines information on baclofen - what its used for, side effects, dosage and who can take it.
Free magazine articles written by the leaders in organic farming. Learn how to grow vegetables & flowers organically with Growing For Market Magazine. Since 1992! Subscribe Today!
... relaxes some criteria for reopening the state, adds that he is trying to empower local health officials to make their own ... As states move towards phased reopening, Governor Newsom (D-Calif.) relaxes some criteria for reopening the state, adds that he ... Newsom relaxes some criteria for reopening the state. 01:57. *Share this - ...
relaxo 0.4.7 Relaxo provides a set of tools and interfaces for interacting with CouchDB. It aims to be as simple and efficient ...
Japan relaxes attendance limit for large events. 9 COVID-19 cases confirmed in Tokyo. ...
V.C. RELAXES WITH FAMILY (1946, April 18). Catholic Weekly (Sydney, NSW : 1942 - 1954), p. 5. Retrieved December 9, 2023, from ... Catholic Weekly (Sydney, NSW : 1942 - 1954), Thu 18 Apr 1946, Page 5 - V.C. RELAXES WITH FAMILY ... "V.C. RELAXES WITH FAMILY" Catholic Weekly (Sydney, NSW : 1942 - 1954) 18 April 1946: 5. Web. 9 Dec 2023 ,http://nla.gov.au/nla. ... 1946 V.C. RELAXES WITH FAMILY, Catholic Weekly (Sydney, NSW : 1942 - 1954), 18 April, p. 5. , viewed 09 Dec 2023, http://nla. ...
Disney World Relaxes Its Mask Mandate. By Rick Munarriz - Feb 16, 2022 at 11:50AM ...
Image of Woman Relaxes On Pink. This free stock photo is also about: Sun, Pink, Woman, Stair, Fashion, Profile, Red Head, Sun ...
Hong Kong reopens beaches, Beijing relaxes quarantine rules Facebook , path id="pathAttribute" d="M 8.917969 7.773438 L ...
Twitter under its 4/20-friendly owner Elon Musk earlier this year became the first major social media company to allow cannabis advertisements.
CAIRO (Reuters) - Egypts army-backed government shortened a nightime curfew by two hours on Saturday, 10 days after imposing it during a fierce crackdown on Muslim Brotherhood protesters in Cairo. Effective immediately, the curfew will last from 9pm to 6am, except on Fridays, when it will still start at 7pm, the Cabinet said in a statement. Read more at straitstimes.com.
Both Riak and CouchDB have had a limited impact on the market, with Basho claiming a few customers but not exhibiting torrential growth, and Cloudant looking much the same, though both CouchDB and Riak have lively mailing lists in which developers and users discuss the technologies.. DB-Engines, which ranks databases according to a combination of online chatter, job listings, technical queries, and Google Trends results, puts CouchDB in 19th place of its database rankings, versus 25th for Riak.. Though both are small compared to the giant systems of Oracle, MySQL, SQL Server, and the like, they are part of a new wave of databases and datastores that run under the banner of "NoSQL" systems.. This frightful term is generally taken to mean that the systems do not use SQL as their query interface, though this has changed over the years as many NoSQL companies have introduced SQL query overlays because having to learn a new query language can alienate a large portion of the potential database ...
Gwyneth Paltrow relaxes beachside on perfect winter holiday in Mexico ... Gwyneth Paltrow relaxes beachside on perfect winter holiday in Mexico. 06 Feb 2015 ...
YouTube today announced an update to its advertiser-friendly guidelines that relaxes some of its rules around controversial ... YouTube relaxes advertiser-friendly guidelines around controversial topics, like abortion, abuse and eating disorders. ... YouTube today announced an update to its advertiser-friendly guidelines that relaxes some of its rules around controversial ...
California state officials on Friday said they will still require masks be worn inside school facilities after the Centers for Disease Control and Prevention...
Relaxin with the Miles Davis Quintet. Artist: Miles Davis Format: Vinyl. New: Call (512) 474-2500 to check in-store ...
FHA Temporarily Relaxes Condo Rules by Calculated Risk on 11/11/2009 11:23:00 AM ...
... which renders relaxin a candidate drug for lung preservation. ... These results show that human relaxin exerts a protective ... Relaxin is a candidate drug for lung preservation: relaxin-induced protection of rat lungs from ischemia-reperfusion injury J ... Methods: Isolated male Wistar rat lungs were perfused in a recirculatory model in the presence of 5-nmol/liter relaxin (n = 17 ... Conclusion: These results show that human relaxin exerts a protective effect in IR-induced lung injury, likely due to ET ...
The Relaxant Action of Nicorandil in Bovine Tracheal Smooth Muscle Subject Area: Pharmacology ... The relaxant mechanisms of nicorandil were examined by comparing its effects with those of sodium nitroprusside and cromakalim ... Their relaxant effects on high K+-contracted preparations were smaller than those on methacholine-contracted muscle. Cromakalim ... Motonari Yunoki, Tsutomu Nakahara, Hiroshi Moriuchi, Kenji Sakamoto, Kunio Ishii; The Relaxant Action of Nicorandil in Bovine ...
Home / Need help now? / First Aid for dogs / Poisons & Toxins / Medication & Drugs / Baclofen (Muscle Relaxant) - dogs ...
The Vivi Relax-a-Bac Premium Swivel Car Seat Cushion turns a full 360 degrees, minimizing the stress on your back, hips or ... HealthSmart Vivi Relax-a-Bac Premium 360 Degree Swivel Seat Cushions - 12.5 Inch Diamter HealthSmart 513-2994-0312 ... Decrease quantity for HealthSmart Vivi Relax-a-Bac Premium 360 Degree Swivel Seat Cushions - 12.5 Inch Diamter Increase ... HomeHealthSmart Vivi Relax-a-Bac Premium 360 Degree Swivel Seat Cushions - 12.5 Inch Diamter *. ...
Germany is revising its rules regarding loan origination by AIFs. But the outcome is not yet clear
  • The relaxant mechanisms of nicorandil were examined by comparing its effects with those of sodium nitroprusside and cromakalim in bovine tracheal smooth muscle. (karger.com)
  • Their relaxant effects on high K + -contracted preparations were smaller than those on methacholine-contracted muscle. (karger.com)
  • These results suggest that nicorandil relaxes bovine tracheal smooth muscle through 2 mechanisms: opening of K ATP channels and activation of the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway. (karger.com)
  • Nicorandil may also activate Maxi K + channels, possibly through the NO-cGMP pathway, and the interaction of K ATP channels and Maxi K + channels may affect the relaxant effect of nicorandil in bovine tracheal smooth muscle. (karger.com)
  • The national drug authority ( Infarmed ) has ordered the immediate suspension of a batch of Sirdalud muscle relaxant due to the detection of out-of-specification values in a dissolution test. (theportugalnews.com)
  • Medicinal plant rosemary relaxes blood vessels by activating vascular smooth muscle KCNQ channels. (bvsalud.org)
  • When that smooth muscle relaxes, it gorges with blood. (medscape.com)
  • Thus, a xylazine-involved case would also sedative with muscle relaxant and analgesic properties ( 1 ). (cdc.gov)
  • Relaxin may affect collagen metabolism, inhibiting collagen synthesis and enhancing its breakdown by increasing matrix metalloproteinases. (wikipedia.org)
  • Hence a single systemic injection of adenovirus producing mouse relaxin reverses cardiac fibrosis without adversely affecting normal collagen levels in other organs and establishes the potential for the use of relaxin gene therapy for the treatment of cardiac fibrosis. (nih.gov)
  • Structurally, relaxin is a heterodimer of two peptide chains of 24 and 29 amino acids linked by three disulfide bridges, and it appears related to insulin. (wikipedia.org)
  • Relaxin is produced from its prohormone, "prorelaxin", by post-translational proteolytic cleavage of its signal peptide and C domain peptide. (wikipedia.org)
  • A single systemic injection of Ad-mRLN resulted in transgene expression in the liver and bioactive relaxin peptide in the plasma. (nih.gov)
  • YouTube today announced an update to its advertiser-friendly guidelines that relaxes some of its rules around controversial issues, including sexual and domestic abuse, abortions and eating disorders. (yahoo.com)
  • The ATP-sensitive K + (K ATP ) channel blocker glibenclamide only partially attenuated the relaxant responses to nicorandil (at 100 and 300 µmol/l). (karger.com)
  • EpDRF release was examined using IL NaCl-stimulated relaxant responses of MCh-contracted preparations. (cdc.gov)
  • A scalp massage not only relaxes the nervous system but also stimulates the brain cells. (yogawiz.com)
  • Blood plasma levels of relaxin peak during the first trimester (8-12 weeks) at 1.2 ng/mL and subsequently drop following demise of the corpus luteum. (wikipedia.org)
  • In pregnancy, relaxin mediates the hemodynamic changes that occur such as increased cardiac output and increased renal blood flow. (wikipedia.org)
  • Via upregulation of VEGF, relaxin also plays a key role in blood vessel formation (angiogenesis) during pregnancy, tumour development or ischaemic wounds. (wikipedia.org)
  • In addition to relaxin production by the horse embryo, the maternal placenta is the main source of relaxin production, whereas in most animals the main source of relaxin is the corpus luteum. (wikipedia.org)
  • Placental trophoblast cells produce relaxin, however, the size of the placenta does not determine the level of relaxin production. (wikipedia.org)
  • During labour, there is a spike in relaxin 3-4 hours before delivery, which is involved in myometrial relaxation and softening of the pelvic ligaments to aid preparation of the birth canal for the delivery of the horse foetus. (wikipedia.org)
  • NEW YORK - MARCH 24: Actress Marilyn Monroe reads the newspaper "Motion Picture Daily" as she relaxes on a couch in her hotel room at the Ambassador Hotel on March 24, 1955 in New York City, New York. (gettyimagesgallery.com)
  • NOW Pets Pet Relaxant is formulated to promote relaxation and contentment during changes to your pet's daily routine, which can include separation, travel, motion sickness and/or tension. (allstarhealth.com)
  • Prior to ovulation, relaxin will be produced by ovarian stromal cells, which will promote secretion of gelatinases and tissue inhibitors of metalloproteinases. (wikipedia.org)
  • During early pregnancy, the preimplantation conceptus will express relaxin, which will promote angiogenesis in the endometrium by up-regulating VEGF. (wikipedia.org)
  • Moreover, the pattern of relaxin expression will follow the expression of oestrogen, however, there is not yet a known link between these two hormones. (wikipedia.org)
  • Recombinant adenoviruses expressing green fluorescent protein (Ad-GFP), rat relaxin (Ad-rRLN) and mouse relaxin (Ad-mRLN) were generated and Ad-rRLN and Ad-mRLN were demonstrated to direct the expression of bioactive relaxin peptides in vitro. (nih.gov)
  • Also, relaxin is found in higher than normal concentrations in the ejaculate of men who were born without their vas deferens and seminal vesicles. (wikipedia.org)
  • This study was conducted to characterize the muscle relaxant activity of methocarbamol enantiomers. (nih.gov)
  • The rotarod test was used to compare the muscle relaxant activity of racemic methocarbamol and pure enantiomers after intraperitoneal administration of the enantiomers to mice. (nih.gov)
  • The results show that (+)-R-methocarbamol has higher muscle relaxant activity compared with racemic methocarbamol or (-)-S-methocarbamol. (nih.gov)
  • Relaxin is a protein hormone of about 6000 Da, first described in 1926 by Frederick Hisaw. (wikipedia.org)
  • Thus, for a long time, relaxin was looked at as a pregnancy hormone. (wikipedia.org)
  • July 5, 2012 - Relaxin, a naturally occurring hormone best known for its properties in causing pelvic expansion and relaxation during pregnancy, shows efficacy as a novel therapy not just for improving functional recovery after stroke but also in treating peripheral artery disease, according to several studies presented here at ENDO 2012: the Endocrine Society 94th Annual Meeting. (medscape.com)
  • Relaxin H2 (RLN2) is a systemic hormone (sRLN) that is produced by the corpus luteum, whereas decidual RLN (dRLN) acts only locally. (nih.gov)
  • In ex vivo experiments using subcutaneous resistance arteries, relaxin has shown to be a powerful endothelium-dependent vasodilator. (wikipedia.org)
  • Instead of moving ahead with the amputation, however, the researchers tried treatment with 2 subcutaneous injections of 1.8 mg relaxin per day for 6 months, and then twice-yearly cycles of 3 months until 2006. (medscape.com)
  • The present invention is directed to novel small molecule agonists of the mammalian relaxin family receptor 1 (RXFP1), including human RXFP1. (nih.gov)
  • It also relaxes other pelvic ligaments in the lower reproductive tract. (wikipedia.org)
  • Small molecule agonists of RXFP1 may be useful in treating acute heart failure (AHF), scleroderma, fibrosis, other conditions associated with the biology of relaxin, and in improving reproductive health and wound healing. (nih.gov)
  • In the cardiovascular system, relaxin is secreted by the heart and functions as a vasodilator mainly through the nitric oxide pathway. (wikipedia.org)
  • Relaxin may be a novel therapy in cardiovascular disease because it induces microvessel dilation, blood flow increase, platelet inhibition and neoangiogenesis, mainly through nitric oxide release," the researchers write. (medscape.com)
  • During labour, there is a spike in relaxin 3-4 hours before delivery, which is involved in myometrial relaxation and softening of the pelvic ligaments to aid preparation of the birth canal for the delivery of the horse foetus. (wikipedia.org)
  • Via upregulation of VEGF, relaxin also plays a key role in blood vessel formation (angiogenesis) during pregnancy, tumour development or ischaemic wounds. (wikipedia.org)
  • This is] suggested by the long-lasting effects, as well as by the evidence of arterial neoformation with relaxin long-term therapy in a peripheral artery disease patient, described by us as a case report," they write. (medscape.com)
  • Blood plasma levels of relaxin peak during the first trimester (8-12 weeks) at 1.2 ng/mL and subsequently drop following demise of the corpus luteum. (wikipedia.org)
  • They randomly assigned 20 patients with peripheral artery disease (mean age, 67 years) into 2 groups, 1 receiving oral porcine relaxin, 20 mg b.i.d. for 12 weeks, and the other a placebo. (medscape.com)
  • endothelium removal had little effect on relaxant activity. (nih.gov)
  • Since then, the patient has been treated with 3-month cycles of oral porcine relaxin twice a year. (medscape.com)
  • Relaxo Footwears Ltd., incorporated in the year 1984, is a Mid Cap company (having a market cap of Rs 25166.42 Crore) operating in Leather sector. (indiatimes.com)
  • Time period given by analyst is one year when Relaxo Footwears Ltd . price can reach defined target. (indiatimes.com)
  • Relaxo Footwears Ltd. key Products/Revenue Segments include Footwear, Scrap, Others, Wind Power, Export Incentives and Other Operating Revenue for the year ending 31-Mar-2021. (indiatimes.com)
  • Studies have shown that relaxin -2 (RLX-2) plays a vital role of endothelial protection , vasodilation , anti- fibrosis and neuroprotection in a variety of diseases . (bvsalud.org)
  • Prior to ovulation, relaxin will be produced by ovarian stromal cells, which will promote secretion of gelatinases and tissue inhibitors of metalloproteinases. (wikipedia.org)
  • Furthermore, granular and theca cells in the follicles will express relaxin in increasing levels depending on their size. (wikipedia.org)
  • Placental trophoblast cells produce relaxin, however, the size of the placenta does not determine the level of relaxin production. (wikipedia.org)
  • inhibiting rho kinase relaxes the cells. (nih.gov)
  • During the first trimester of pregnancy, levels rise and additional relaxin is produced by the decidua. (wikipedia.org)
  • Also, relaxin is found in higher than normal concentrations in the ejaculate of men who were born without their vas deferens and seminal vesicles. (wikipedia.org)
  • HDFC Securities has sell call on Relaxo Footwears with a target price of Rs 850. (indiatimes.com)
  • The current market price of Relaxo Footwears is Rs 1003.5. (indiatimes.com)
  • This mouse Relaxin 1 ELISA Kit was based on standard sandwich enzyme-linked immune-sorbent assay technology. (innov-research.com)
  • Relaxin levels rise to a peak within approximately 14 days of ovulation, and then decline in the absence of pregnancy, resulting in menstruation. (wikipedia.org)
  • In horses alone, the embryo in the uterus will express relaxin mRNA at least 8 days after ovulation. (wikipedia.org)
  • Analyses performed at baseline and at 20 and 40 days showed that patients who received relaxin had greater improvements in general conditions and rehabilitation exercises. (medscape.com)
  • it also relaxes your body so that it's conditioned for a good night's rest. (thebitbag.com)
  • In 1 study, said to be the first of its kind to evaluate relaxin in stroke patients, 36 poststroke patients were randomly assigned into 2 groups of 18 patients each, with 1 group receiving rehabilitation in addition to oral porcine relaxin ( Vitalaxin Plus , Sky BioHealth), 40 mg/day, and the other group receiving only rehabilitation. (medscape.com)
  • In another study, Dr. Bigazzi and colleagues hypothesized that relaxin could be effective in the treatment of peripheral artery disease for various reasons. (medscape.com)
  • We're excited to partner with our friends at Craft Recordings for a very special giveaway for a copy of the Small Batch pressing of Relaxin' with the Miles Davis Quintet , the newest edition of their all-analog, one-step lacquer process series. (milesdavis.com)
  • During early pregnancy, the preimplantation conceptus will express relaxin, which will promote angiogenesis in the endometrium by up-regulating VEGF. (wikipedia.org)
  • Relaxin may be involved in the vital process of decidualisation, working alongside steroid hormones to allow the endometrium to prepare for implantation. (wikipedia.org)