Receptors fc. Medical search

Specific molecular sites on the surface of various cells, including B-lymphocytes and macrophages, that combine with IMMUNOGLOBULIN Gs. Three subclasses exist: Fc gamma RI (the CD64 antigen, a low affinity receptor), Fc gamma RII (the CD32 antigen, a high affinity receptor), and Fc gamma RIII (the CD16 antigen, a low affinity receptor).

Specific molecular sites on the surface of B- and T-lymphocytes which combine with IgEs. Two subclasses exist: low affinity receptors (Fc epsilon RII) and high affinity receptors (Fc epsilon RI).

Molecules found on the surface of some, but not all, B-lymphocytes, T-lymphocytes, and macrophages, which recognize and combine with the Fc (crystallizable) portion of immunoglobulin molecules.

Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.

Enhancement of viral infectivity caused by non-neutralizing antibodies. There are at least two mechanisms known to account for this: mediation by Fc receptors (RECEPTORS, FC) or by complement receptors (RECEPTORS, COMPLEMENT). Either the virus is complexed with antiviral IMMUNOGLOBULIN G and binds to Fc receptors, or virus is coated with antiviral IMMUNOGLOBULIN M and binds to complement receptors.

Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)

The phenomenon of antibody-mediated target cell destruction by non-sensitized effector cells. The identity of the target cell varies, but it must possess surface IMMUNOGLOBULIN G whose Fc portion is intact. The effector cell is a "killer" cell possessing Fc receptors. It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent.

The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).

Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.

Non-hematopoietic cells, with extensive dendritic processes, found in the primary and secondary follicles of lymphoid tissue (the B cell zones). They are different from conventional DENDRITIC CELLS associated with T-CELLS. They are derived from MESENCHYMAL STEM CELLS and are negative for class II MHC antigen and do not process or present antigen like the conventional dendritic cells do. Instead, follicular dendritic cells have FC RECEPTORS and C3B RECEPTORS that hold antigen in the form of ANTIGEN-ANTIBODY COMPLEXES on their surfaces for long periods for recognition by B-CELLS.

Characterization of the interaction between the herpes simplex virus type I Fc receptor and immunoglobulin G. (1/2162)

Herpes simplex virus type I (HSV-1) virions and HSV-1-infected cells bind to human immunoglobulin G (hIgG) via its Fc region. A complex of two surface glycoproteins encoded by HSV-1, gE and gI, is responsible for Fc binding. We have co-expressed soluble truncated forms of gE and gI in Chinese hamster ovary cells. Soluble gE-gI complexes can be purified from transfected cell supernatants using a purification scheme that is based upon the Fc receptor function of gE-gI. Using gel filtration and analytical ultracentrifugation, we determined that soluble gE-gI is a heterodimer composed of one molecule of gE and one molecule of gI and that gE-gI heterodimers bind hIgG with a 1:1 stoichiometry. Biosensor-based studies of the binding of wild type or mutant IgG proteins to soluble gE-gI indicate that histidine 435 at the CH2-CH3 domain interface of IgG is a critical residue for IgG binding to gE-gI. We observe many similarities between the characteristics of IgG binding by gE-gI and by rheumatoid factors and bacterial Fc receptors such as Staphylococcus aureus protein A. These observations support a model for the origin of some rheumatoid factors, in which they represent anti-idiotypic antibodies directed against antibodies to bacterial and viral Fc receptors. (+info)

Alternative endocytic pathway for immunoglobulin A Fc receptors (CD89) depends on the lack of FcRgamma association and protects against degradation of bound ligand. (2/2162)

IgA is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum because it is catabolized faster than IgG. IgA exists in monomeric and polymeric forms that function through receptors expressed on effector cells. Here, we show that IgA Fc receptor(s) (FcalphaR) are expressed with or without the gamma chain on monocytes and neutrophils. gamma-less FcalphaR represent a significant fraction of surface FcalphaR molecules even on cells overexpressing the gamma chain. The FcalphaR-gamma2 association is up-regulated by phorbol esters and interferon-gamma. To characterize gamma-less FcalphaR functionally, we generated mast cell transfectants expressing wild-type human FcalphaR or a receptor with a point mutation (Arg --> Leu at position 209) which was unable to associate with the gamma chain. Mutant gamma-less FcalphaR bound monomeric and polymeric human IgA1 or IgA2 but failed to induce exocytosis after receptor clustering. The two types of transfectant showed similar kinetics of FcalphaR-mediated endocytosis; however, the endocytosis pathways of the two types of receptor differed. Whereas mutant FcalphaR were localized mainly in early endosomes, those containing FcalphaR-gamma2 were found in endo-lysosomal compartments. Mutant gamma-less FcalphaR recycled the internalized IgA toward the cell surface and protected against IgA degradation. Cells expressing the two forms of FcalphaR, associated or unassociated with gamma chains, may thus have differential functions either by degrading IgA antibody complexes or by recycling serum IgA. (+info)

Fc receptor beta subunit is required for full activation of mast cells through Fc receptor engagement. (3/2162)

The high-affinity IgE receptor (Fc epsilonRI) and the low-affinity IgG receptor (Fc gammaRIII) on mast cells are the key molecules involved in triggering the allergic reaction. These receptors share the common beta subunit (FcRbeta) which contains an immunoreceptor tyrosine-based activation motif and transduces the signals of these receptors' aggregation. In rodents, FcRbeta is essential for the cell surface expression of the Fc epsilonRI. In humans, the FcRbeta gene was reported to be one of the candidate genes causing atopic diseases. However, the role of FcRbeta in vivo still remains ambiguous. To elucidate the functions of FcRbeta, we developed the mice lacking FcRbeta [FcRbeta(-/-)]. The FcRbeta(-/-) mice lacked the expression of the Fc epsilonRI on mast cells and IgE-mediated passive cutaneous anaphylaxis (PCA) was not induced in FcRbeta(-/-) mice as was expected. In these mice, the expression of IgG receptors on mast cells was augmented but the IgG-mediated PCA reaction was attenuated. Although with bone marrow-derived cultured mast cells from FcRbeta(-/-), adhesion to fibronectin and Ca2+ flux upon aggregation of IgG receptors were enhanced, mast cells co-cultured with 3T3 fibroblasts exhibited impaired degranulation on receptor aggregation. These observations indicate that FcRbeta accelerates the degranulation of mature mast cells via the IgG receptor in connective tissues. (+info)

Nonvectorial surface transport, endocytosis via a Di-leucine-based motif, and bidirectional transcytosis of chimera encoding the cytosolic tail of rat FcRn expressed in Madin-Darby canine kidney cells. (4/2162)

Transfer of passive immunity from the mother to the fetus or newborn involves the transport of IgG across several epithelia. Depending on the species, IgG is transported prenatally across the placenta and yolk sac or is absorbed from colostrum and milk by the small intestine of the suckling newborn. In both cases apical to basolateral transepithelial transport of IgG is thought to be mediated by FcRn, an IgG Fc receptor with homology to major histocompatibility class I antigens. Here, we analyzed the intracellular routing of chimera encoding the rat FcRn tail fused to the ecto- and transmembrane domain of the macrophage FcgammaRIIb. Newly synthesized chimera were delivered in a nonvectorial manner to the apical and basolateral cell surface, from where the chimera were able to internalize and transcytose. Apical to basolateral and basolateral to apical transcytosis were differently regulated. This intracellular routing of the chimera is similar to that of the native FcRn, indicating that the cytosolic tail of the receptor is necessary and sufficient to endow an unrelated FcR with the intracellular transport behavior of FcRn. Furthermore, the di-leucine motif in the cytosolic domain of FcRn was required for rapid and efficient endocytosis but not for basolateral sorting of the chimera. (+info)

Modulation of the humoral immune response by antibody-mediated antigen targeting to complement receptors and Fc receptors. (5/2162)

During an ongoing immune response, immune complexes, composed of Ag, complement factors, and Igs, are formed that can interact with complement receptors (CRs) and IgG Fc receptors (Fc gamma R). The role of CR1/2 and Fc gamma R in the regulation of the immune response was investigated using OVA that was chemically conjugated to whole IgG of the rat anti-mouse CR1/2 mAb 7G6. FACS analysis using the murine B cell lymphoma IIA1.6 confirmed that the 7G6-OVA conjugate recognized CR1/2. Incubating IIA1.6 cells with 7G6-OVA triggered tyrosine phosphorylation and Ag presentation to OVA-specific T cells in vitro. Immunizing mice with 7G6-OVA at a minimal dose of 1 microgram i.p. per mouse markedly enhanced the anti-OVA Ig response, which was primarily of the IgG1 isotype subclass. The 7G6-OVA did not enhance the anti-OVA response in CR1/2-deficient mice. OVA coupled to an isotype control Ab induced a considerably lower anti-OVA response compared with that induced by OVA alone, suggesting inhibition by interaction between the Fc part of the Ab and the inhibitory Fc gamma RIIb on B cells. This findings was supported by the observation that IIA1.6 cells which were incubated with 7G6-OVA lost the ability to present Ag upon transfection with Fc gamma RIIb. In sum, 7G6-conjugated OVA, resembling a natural immune complex, induces an enhanced anti-OVA immune response that involves at least CR1/2-mediated stimulation and that may be partially suppressed by Fc gamma RIIb. (+info)

Human mesangial cells in culture and in kidney sections fail to express Fc alpha receptor (CD89). (6/2162)

The mechanism of deposition of IgA in the renal mesangium in primary IgA-nephropathy is poorly understood. It has been suggested that membrane receptors for IgA on mesangial cells (MC) of the kidney may be involved. To obtain more insight in the occurrence of the myeloid receptor for IgA (CD89) on MC, both in situ and in culture, rabbit and goat polyclonal antibodies and mouse monoclonal antibody against recombinant CD89 were raised. Kidney sections from five control subjects and five patients with primary IgA-nephropathy failed to be positive for CD89 in the mesangium, using our polyclonal and monoclonal antibodies. Also, five primary human MC cultures assessed for CD89 expression showed no protein expression of CD89. Furthermore, reverse transcription-PCR failed to detect mRNA expression of CD89 in the cultured MC. It was demonstrated that all five human primary MC bound human IgA in a dose-dependent manner, which was not inhibitable by blocking monoclonal anti-CD89 antibody (My43). In contrast, binding of IgA to U937 cells was blocked efficiently by My43. Finally, incubation of human MC with either human or rat IgA led to increased interleukin-6 production, whereas only human IgA, but not rat IgA, was able to bind to human CD89. Therefore, it is concluded that human MC do not express CD89 (to a significant extent). These results strongly suggest that binding of IgA to human MC occurs via an IgA receptor distinct from CD89. (+info)

B lymphocytes as antigen-presenting cells for CD4+ T cell priming in vivo. (7/2162)

The contribution of B lymphocytes as APCs for CD4+ T cell priming remains controversial, based on findings that B cells cannot provide the requisite ligating and costimulatory signals for naive T cells to be activated. In the current study, we have examined Ag-specific T:B cell collaboration under circumstances in which B cells take up Ag through Ig receptors in vivo. This results in their activation and an ability to effectively stimulate naive CD4+ T cells both in vitro and in vivo. The aim of this work was to establish some of the key molecular interactions, as well as kinetics, between Ag-specific T and B cells that enable this priming to take place. Our approach was to amplify the starting pools of both Ag-specific T and B cell populations in vivo to track directly the events during initial T:B cell collaborations. We show that the induction of optimal levels of T cell priming to a protein Ag requires the involvement of Ag-specific B cells. The interaction that results between Ag-specific T and B cells prevents the down-modulation of B7 costimulatory molecules usually observed in the absence of appropriate T cells. Moreover, this prevention in down-modulation is independent of CD40:CD40 ligand contact. Finally, we present data suggesting that once Ag-specific T and B cells interact, there is a rapid (1-2-h) down-regulation of antigenic complexes on the surface of the B lymphocytes, possibly to prevent them from engaging other T cells in the vicinity and therefore focus the initial interaction. (+info)

Improving the efficacy of antibody-interleukin 2 fusion proteins by reducing their interaction with Fc receptors. (8/2162)

Fusion proteins between whole antibodies (Abs) and cytokines (immunocytokines) such as interleukin 2 have shown efficacy in several mouse tumor models despite a circulating half-life that is significantly shorter than that of the original Ab. We have examined the potential mechanisms responsible for clearance and shown that an important factor is enhanced binding to Fc receptor (FcR). Improvements in the half-lives of two different immunocytokines were made by changing the isotype of the human heavy chain C region from IgG1 or IgG3 to those with reduced binding to FcR, e.g., IgG4. The same effect could also be achieved through site-directed mutagenesis of the FcR binding site in the IgG1 H chain. In vitro studies using mouse J774 FcR-expressing cells showed increased binding of interleukin 2-based immunocytokines, relative to their corresponding Abs, and that this was reversed in those fusion proteins made with IgG4 or mutated IgG1 H chains. All of the fusion proteins showing reduced FcR binding also had reduced Ab-dependent cellular cytotoxicity activity, as measured in 4-h chromium release assays. A complete loss of complement-dependent cytotoxicity activity was seen with an IgG4-based immunocytokine derived from an IgG1 Ab with potent activity. Despite these reduced effector functions, the IgG4-based immunocytokines with extended circulating half-lives showed equivalent (in the case of severe combined immunodeficiency mouse xenograft models) or better (in the case of syngeneic models) efficacy in mouse tumor models than the original IgG1-based molecules. These novel immunocytokines may show improved efficacy in therapeutic situations where T cell- rather than natural killer- or complement-mediated antitumor mechanisms are involved. (+info)

IgG receptors, also known as Fcγ receptors (Fc gamma receptors), are specialized protein molecules found on the surface of various immune cells, such as neutrophils, monocytes, macrophages, and some lymphocytes. These receptors recognize and bind to the Fc region of IgG antibodies, one of the five classes of immunoglobulins in the human body.

IgG receptors play a crucial role in immune responses by mediating different effector functions, including:

1. Antibody-dependent cellular cytotoxicity (ADCC): IgG receptors on natural killer (NK) cells and other immune cells bind to IgG antibodies coated on the surface of virus-infected or cancer cells, leading to their destruction.
2. Phagocytosis: When IgG antibodies tag pathogens or foreign particles, phagocytes like neutrophils and macrophages recognize and bind to these immune complexes via IgG receptors, facilitating the engulfment and removal of the targeted particles.
3. Antigen presentation: IgG receptors on antigen-presenting cells (APCs) can internalize immune complexes, process the antigens, and present them to T cells, thereby initiating adaptive immune responses.
4. Inflammatory response regulation: IgG receptors can modulate inflammation by activating or inhibiting downstream signaling pathways in immune cells, depending on the specific type of Fcγ receptor and its activation state.

There are several types of IgG receptors (FcγRI, FcγRII, FcγRIII, and FcγRIV) with varying affinities for different subclasses of IgG antibodies (IgG1, IgG2, IgG3, and IgG4). The distinct functions and expression patterns of these receptors contribute to the complexity and fine-tuning of immune responses in the human body.

IgE receptors, also known as Fc epsilon RI receptors, are membrane-bound proteins found on the surface of mast cells and basophils. They play a crucial role in the immune response to parasitic infections and allergies. IgE receptors bind to the Fc region of immunoglobulin E (IgE) antibodies, which are produced by B cells in response to certain antigens. When an allergen cross-links two adjacent IgE molecules bound to the same IgE receptor, it triggers a signaling cascade that leads to the release of mediators such as histamine, leukotrienes, and prostaglandins. These mediators cause the symptoms associated with allergic reactions, including inflammation, itching, and vasodilation. IgE receptors are also involved in the activation of the adaptive immune response by promoting the presentation of antigens to T cells.

Fc receptors (FcRs) are specialized proteins found on the surface of various immune cells, including neutrophils, monocytes, macrophages, eosinophils, basophils, mast cells, and B lymphocytes. They play a crucial role in the immune response by recognizing and binding to the Fc region of antibodies (IgG, IgA, and IgE) after they have interacted with their specific antigens.

FcRs can be classified into several types based on the class of antibody they bind:

1. FcγRs - bind to the Fc region of IgG antibodies
2. FcαRs - bind to the Fc region of IgA antibodies
3. FcεRs - bind to the Fc region of IgE antibodies

The binding of antibodies to Fc receptors triggers various cellular responses, such as phagocytosis, degranulation, and antibody-dependent cellular cytotoxicity (ADCC), which contribute to the elimination of pathogens, immune complexes, and other foreign substances. Dysregulation of Fc receptor function has been implicated in several diseases, including autoimmune disorders and allergies.

Immunoglobulin Fc fragments are the crystallizable fragment of an antibody that is responsible for effector functions such as engagement with Fc receptors on immune cells, activation of the complement system, and neutralization of toxins. The Fc region is located at the tail end of the Y-shaped immunoglobulin molecule, and it is made up of constant regions of the heavy chains of the antibody.

When an antibody binds to its target antigen, the Fc region can interact with other proteins in the immune system, leading to a variety of responses such as phagocytosis, antibody-dependent cellular cytotoxicity (ADCC), and complement activation. These effector functions help to eliminate pathogens and infected cells from the body.

Immunoglobulin Fc fragments can be produced artificially through enzymatic digestion of intact antibodies, resulting in a fragment that retains the ability to interact with Fc receptors and other proteins involved in immune responses. These fragments have potential therapeutic applications in a variety of diseases, including autoimmune disorders, inflammatory conditions, and cancer.

Antibody-Dependent Enhancement (ADE) is a phenomenon in which the presence of antibodies against a particular virus actually enhances the ability of the virus to infect and replicate within host cells, leading to increased severity of infection. This occurs when the antibodies bind to the virus but do not neutralize it, instead facilitating uptake of the virus into immune cells expressing Fc receptors, such as macrophages. The virus can then use these cells as a site for replication and evasion of the host's immune response. ADE has been observed in various viral infections, including dengue fever and respiratory syncytial virus (RSV) infection. It is a concern in the development of vaccines against these viruses, as non-neutralizing antibodies induced by vaccination could potentially enhance subsequent infection with a heterologous strain of the virus.

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

Antibody-Dependent Cell Cytotoxicity (ADCC) is a type of immune response in which the effector cells of the immune system, such as natural killer (NK) cells, cytotoxic T-cells or macrophages, recognize and destroy virus-infected or cancer cells that are coated with antibodies.

In this process, an antibody produced by B-cells binds specifically to an antigen on the surface of a target cell. The other end of the antibody then interacts with Fc receptors found on the surface of effector cells. This interaction triggers the effector cells to release cytotoxic substances, such as perforins and granzymes, which create pores in the target cell membrane and induce apoptosis (programmed cell death).

ADCC plays an important role in the immune defense against viral infections and cancer. It is also a mechanism of action for some monoclonal antibody therapies used in cancer treatment.

Phagocytosis is the process by which certain cells in the body, known as phagocytes, engulf and destroy foreign particles, bacteria, or dead cells. This mechanism plays a crucial role in the immune system's response to infection and inflammation. Phagocytes, such as neutrophils, monocytes, and macrophages, have receptors on their surface that recognize and bind to specific molecules (known as antigens) on the target particles or microorganisms.

Once attached, the phagocyte extends pseudopodia (cell extensions) around the particle, forming a vesicle called a phagosome that completely encloses it. The phagosome then fuses with a lysosome, an intracellular organelle containing digestive enzymes and other chemicals. This fusion results in the formation of a phagolysosome, where the engulfed particle is broken down by the action of these enzymes, neutralizing its harmful effects and allowing for the removal of cellular debris or pathogens.

Phagocytosis not only serves as a crucial defense mechanism against infections but also contributes to tissue homeostasis by removing dead cells and debris.

Natural Killer (NK) cells are a type of lymphocyte, which are large granular innate immune cells that play a crucial role in the host's defense against viral infections and malignant transformations. They do not require prior sensitization to target and destroy abnormal cells, such as virus-infected cells or tumor cells. NK cells recognize their targets through an array of germline-encoded activating and inhibitory receptors that detect the alterations in the cell surface molecules of potential targets. Upon activation, NK cells release cytotoxic granules containing perforins and granzymes to induce target cell apoptosis, and they also produce a variety of cytokines and chemokines to modulate immune responses. Overall, natural killer cells serve as a critical component of the innate immune system, providing rapid and effective responses against infected or malignant cells.

Follicular dendritic cells (FDCs) are a specialized type of dendritic cell that reside in the germinal centers of secondary lymphoid organs, such as the spleen, lymph nodes, and Peyer's patches. They play a critical role in the adaptive immune response by presenting antigens to B cells and helping to regulate their activation, differentiation, and survival.

FDCs are characterized by their extensive network of dendrites, which can trap and retain antigens on their surface for extended periods. They also express a variety of surface receptors that allow them to interact with other immune cells, including complement receptors, Fc receptors, and cytokine receptors.

FDCs are derived from mesenchymal stem cells and are distinct from classical dendritic cells, which are derived from hematopoietic stem cells. They are long-lived cells that can survive for months or even years in the body, making them important players in the maintenance of immune memory.

Overall, follicular dendritic cells play a critical role in the adaptive immune response by helping to regulate B cell activation and differentiation, and by contributing to the development of immune memory.

FcγR), those that bind IgA are called Fc-alpha receptors (FcαR) and those that bind IgE are called Fc-epsilon receptors (FcεR ... Only one Fc receptor belongs to the FcαR subgroup, which is called FcαRI (or CD89). FcαRI is found on the surface of ... All of the Fcγ receptors (FcγR) belong to the immunoglobulin superfamily and are the most important Fc receptors for inducing ... This family includes several members, FcγRI (CD64), FcγRIIA (CD32), FcγRIIB (CD32), FcγRIIIA (CD16a), FcγRIIIB (CD16b), which ...

https://en.wikipedia.org/wiki/Fc_receptor

The neonatal Fc receptor (also FcRn, IgG receptor FcRn large subunit p51, or Brambell receptor) is a protein that in humans is ... Sockolosky JT, Szoka FC (August 2015). "The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy". Advanced ... Patel DA, Puig-Canto A, Challa DK, Perez Montoyo H, Ober RJ, Ward ES (July 2011). "Neonatal Fc receptor blockade by Fc ... Neonatal Fc receptor expression is up-regulated by the proinflammatory cytokine, TNF, and down-regulated by IFN-γ. In addition ...

https://en.wikipedia.org/wiki/Neonatal_Fc_receptor

... s (FCRLs) are a class of proteins that resemble Fc receptors. They have been characterized in a number ... FCRLB Fc receptor Davis RS (2007). "Fc receptor-like molecules". Annual Review of Immunology. 25: 525-60. doi:10.1146/annurev. ... Unlike the classical Fc receptors, there is no strong evidence that suggests that FCRLs bind to the Fc portion of antibodies. ... "Immunoregulatory Roles for Fc Receptor-Like Molecules". In Ahmed R, Honjo T (eds.). Negative Co-Receptors and Ligands. Current ...

https://en.wikipedia.org/wiki/Fc_receptor-like_molecule

Colpaert FC (January 2006). "5-HT(1A) receptor activation: new molecular and neuroadaptive mechanisms of pain relief". Current ... The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptors, or 5-HT receptors, that binds serotonin, ... The 5-HT1A receptor is the most widespread of all the 5-HT receptors. In the central nervous system, 5-HT1A receptors exist in ... 5-HT1A receptors in the dorsal raphe nucleus are co-localized with neurokinin 1 (NK1) receptors and have been shown to inhibit ...

https://en.wikipedia.org/wiki/5-HT1A_receptor

Kimberley FC, Screaton GR (2005). "Following a TRAIL: update on a ligand and its five receptors". Cell Res. 14 (5): 359-72. doi ... Death receptor 4 (DR4), also known as TRAIL receptor 1 (TRAILR1) and tumor necrosis factor receptor superfamily member 10A ( ... The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis ... TNFRSF10A), is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL and mediates apoptosis. ...

https://en.wikipedia.org/wiki/Death_receptor_4

Kimberley FC, Screaton GR (2005). "Following a TRAIL: update on a ligand and its five receptors". Cell Res. 14 (5): 359-72. doi ... Decoy receptor 1 (DCR1), also known as TRAIL receptor 3 (TRAILR3) and tumor necrosis factor receptor superfamily member 10C ( ... This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells ... The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL- ...

https://en.wikipedia.org/wiki/Decoy_receptor_1

"Entrez Gene: TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain". Kimberley FC ... Decoy receptor 2 (DCR2), also known as TRAIL receptor 4 (TRAILR4) and tumor necrosis factor receptor superfamily member 10D ( ... The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL- ... This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. GRCh38 ...

https://en.wikipedia.org/wiki/Decoy_receptor_2

Hoffman M, Church FC (August 1993). "Response of blood leukocytes to thrombin receptor peptides". Journal of Leukocyte Biology ... Proteinase-activated receptor 1 (PAR1) also known as protease-activated receptor 1 or coagulation factor II (thrombin) receptor ... PAR1 is a G protein-coupled receptor and one of four protease-activated receptors involved in the regulation of thrombotic ... Howell DC, Laurent GJ, Chambers RC (April 2002). "Role of thrombin and its major cellular receptor, protease-activated receptor ...

https://en.wikipedia.org/wiki/Coagulation_factor_II_receptor

Kimberley FC, Screaton GR (Oct 2004). "Following a TRAIL: update on a ligand and its five receptors". Cell Research. 14 (5): ... Death receptor 5 (DR5), also known as TRAIL receptor 2 (TRAILR2) and tumor necrosis factor receptor superfamily member 10B ( ... Pan G, Ni J, Wei YF, Yu G, Gentz R, Dixit VM (Aug 1997). "An antagonist decoy receptor and a death domain-containing receptor ... is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL and mediates apoptosis. The protein encoded by this ...

https://en.wikipedia.org/wiki/Death_receptor_5

Tortella FC, Robles L, Holaday JW (April 1986). "U50,488, a highly selective kappa opioid: anticonvulsant profile in rats". The ... δ-opioid receptor μ-opioid receptor Nociceptin receptor GRCh38: Ensembl release 89: ENSG00000082556 - Ensembl, May 2017 GRCm38 ... The κ-opioid receptor or kappa opioid receptor, abbreviated KOR or KOP for its ligand ketazocine, is a G protein-coupled ... Dysregulation of this receptor system has been implicated in alcohol and drug addiction. The KOR is a type of opioid receptor ...

https://en.wikipedia.org/wiki/Κ-opioid_receptor

Azizi AA, Pillai M, Thistlethwaite FC (September 2019). "T-cell receptor and chimeric antigen receptor in solid cancers: ... T cell receptor T cell therapy (TCR-T) is a type of cancer immunotherapy. TCR-T therapies use heterodimers made of alpha and ... Zhang M, Zhang DB, Shi H (September 2017). "Application of chimeric antigen receptor-engineered T cells in ovarian cancer ... Oppermans N, Kueberuwa G, Hawkins RE, Bridgeman JS (January 2020). "Transgenic T-cell receptor immunotherapy for cancer: ...

https://en.wikipedia.org/wiki/T_cell_receptor_T_cell_therapy

Finally, there is CD16, a low affinity Fc receptor (FcγRIII) which contains N-glycosylation sites; therefore, it is a ... Killer-cell inhibitory receptors involve both immunoglobulin-like receptors and C-type lectin-like receptors. There are two ... Killer Activation Receptor (KAR) and Killer Inhibition Receptors (KIRs). Both type of receptors act together to activate or not ... Killer Activation Receptors) and the NK KIRs (meaning: Killer Inhibitory Receptors). Such receptors have a broad binding ...

https://en.wikipedia.org/wiki/Killer_activation_receptor

Tcherpakov M, Bronfman FC, Conticello SG, Vaskovsky A, Levy Z, Niinobe M, et al. (December 2002). "The p75 neurotrophin ... The p75 neurotrophin receptor (p75NTR) was first identified in 1973 as the low-affinity nerve growth factor receptor (LNGFR) ... p75NTR/LNGFR was the first member of this large family of receptors to be characterized, that now contains about 25 receptors, ... Buxser S, Puma P, Johnson GL (February 1985). "Properties of the nerve growth factor receptor. Relationship between receptor ...

https://en.wikipedia.org/wiki/Low-affinity_nerve_growth_factor_receptor

"Human mononuclear phagocytes express adenosine A1 receptors. A novel mechanism for differential regulation of Fc gamma receptor ... As a result, Adenosine receptor A2A decreases activity in the Dopamine D2 receptors. The adenosine A2A receptor has also been ... "Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor". Genomics. 11 (1 ... "Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor". Genomics. 11 (1 ...

https://en.wikipedia.org/wiki/Adenosine_A2A_receptor

Kelleher FC, O'Sullivan H, Smyth E, McDermott R, Viterbo A (October 2013). "Fibroblast growth factor receptors, developmental ... Fibroblast growth factor receptor 3 is a protein that in humans is encoded by the FGFR3 gene. FGFR3 has also been designated as ... The FGFR3 receptor has a tyrosine kinase signaling pathway that is associated with many biological developments embryonically ... The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is ...

https://en.wikipedia.org/wiki/Fibroblast_growth_factor_receptor_3

Bardin L, Tarayre JP, Malfetes N, Koek W, Colpaert FC (April 2003). "Profound, non-opioid analgesia produced by the high- ... 5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand- ... 5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors are found in the central and peripheral nervous systems ... The 7 general serotonin receptor classes include a total of 14 known serotonin receptors. The 15th receptor 5-HT1P has been ...

https://en.wikipedia.org/wiki/5-HT_receptor

Retondaro FC, Dos Santos Costa PC, Pedrosa RC, Kurtenbach E (November 1999). "Presence of antibodies against the third ... The muscarinic acetylcholine receptor M2, also known as the cholinergic receptor, muscarinic 2, is a muscarinic acetylcholine ... Both M2 and M3 muscarinic receptors are expressed in the smooth muscles of the airway, with the majority of the receptors being ... "Acetylcholine receptors (muscarinic): M2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and ...

https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M2

The murine lymphocyte receptor for IgE. V. Biosynthesis, transport, and maturation of the B cell Fc epsilon receptor. J Immunol ... The interleukin-13 receptor is a type I cytokine receptor, binding Interleukin-13. It consists of two subunits, encoded by ... IL-4 receptor type II). A "private" receptor system, binding specifically IL-13 with high affinity, seems to use different ... Lin C, Liu H, Zhang H, He H, Li H, Shen Z, Qin J, Qin X, Xu J, Sun Y (August 2016). "Interleukin-13 receptor α2 is associated ...

https://en.wikipedia.org/wiki/Interleukin-13_receptor

Stomski FC, Woodcock JM, Zacharakis B, Bagley CJ, Sun Q, Lopez AF (1998). "Identification of a Cys motif in the common beta ... IL-2 receptor IL-4 receptor IL-7 receptor IL-9 receptor IL-13 receptor IL-15 receptor IL-21 receptor The common beta chain ( ... receptor GM-CSF receptor G-CSF receptor Thrombopoietin receptor Growth hormone receptor Prolactin receptor Leptin receptor ... IL-6 receptor IL-11 receptor IL-12 receptor IL-27 receptor Leukemia inhibitory factor receptor Oncostatin M receptor Type I ...

https://en.wikipedia.org/wiki/Type_I_cytokine_receptor

Chen CH, Liu MY, Wei FC, Koong FJ, Hwu HG, Hsiao KJ (February 1997). "Further evidence of no association between Ser9Gly ... This receptor is expressed in phylogenetically older regions of the brain, suggesting that this receptor plays a role in ... "Dopamine Receptors: D3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology ... "Entrez Gene: DRD3 dopamine receptor D3". Joyce JN, Millan MJ (February 2007). "Dopamine D3 receptor agonists for protection and ...

https://en.wikipedia.org/wiki/Dopamine_receptor_D3

Bender FC, Whitbeck JC, Ponce de Leon M, Lou H, Eisenberg RJ, Cohen GH (2003). "Specific Association of Glycoprotein B with ... "Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor". Science. 280 (5369): ... Poliovirus receptor-related 1 (PVRL1), also known as nectin-1 and CD111 (formerly herpesvirus entry mediator C, HVEC) is a ... Cocchi F, Lopez M, Menotti L, Aoubala M, Dubreuil P, Campadelli-Fiume G (1999). "The V domain of herpesvirus Ig-like receptor ( ...

https://en.wikipedia.org/wiki/Poliovirus_receptor-related_1

Frías JP, Davies MJ, Rosenstock J, Pérez Manghi FC, Fernández Landó L, Bergman BK, et al. (August 2021). "Tirzepatide versus ... Glucagon-like peptide-1 receptor agonists, also known as GLP-1 receptor agonists (GLP-1-RA), incretin mimetics, or GLP-1 ... Some GLP-1 receptor agonists have been used off-label for obesity and impulse control. Gray market sellers offer unauthorized ... Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial". The New England Journal of Medicine. doi:10.1056/ ...

https://en.wikipedia.org/wiki/Glucagon-like_peptide-1_receptor_agonist

Yung LY, Tsim KW, Pei G, Wong YH (2000). "Immunoglobulin G1 Fc fragment-tagged human opioid receptor-like receptor retains the ... receptor or kappa-type 3 opioid receptor, is a protein that in humans is encoded by the OPRL1 (opioid receptor-like 1) gene. ... "Orphanin FQ/nociceptin-mediated desensitization of opioid receptor-like 1 receptor and mu opioid receptors involves protein ... cloned a receptor that was highly homologous to the classical opioid receptors (OPs) μ-OR (MOP), κ-OR (KOP), and δ-OR (DOP) ...

https://en.wikipedia.org/wiki/Nociceptin_receptor

... a unique module linking antigen and Fc receptors to their signaling cascades". Journal of Leukocyte Biology. 61 (1): 6-16. doi: ... hence the receptors are referred to as tyrosine-phosphorylated receptors. They are called non-catalytic receptors, as the ... The receptor signaling pathway is initiated by ligand binding to the extracellular domains of the receptor. Upon binding, the ... A prominent member of this receptor family is the T-cell receptor. Members of the Non-catalytic tyrosine-phosphorylated ...

https://en.wikipedia.org/wiki/Non-catalytic_tyrosine-phosphorylated_receptor

"Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain ... Discoidin domain receptors form a subgroup of receptor tyrosine kinases. Receptor activation happens when collagen binds into ... Mannose receptor provide reception of extracellular ligands. To the family of mannose receptors belong: mannose receptor, M- ... The exact way of receptor activation is unknown so far. Unlike other tyrosine-kinase receptors, maximal activation of receptors ...

https://en.wikipedia.org/wiki/Collagen_receptor

2007). "Mast cells express IL-13R alpha 1: IL-13 promotes human lung mast cell proliferation and Fc epsilon RI expression". ... This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves ... Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chains". J. Biol. Chem. 272 (14): 9474-80. ... Interleukin 13 receptor, alpha 1, also known as IL13RA1 and CD213A1 (cluster of differentiation 213A1), is a human gene. The ...

https://en.wikipedia.org/wiki/Interleukin_13_receptor,_alpha_1

In particular, the neonatal Fc receptor (FcRn) binds to the Fc region of IgG antibodies to transport it across the placenta, ... Those cells that recognize coated pathogens have Fc receptors, which, as the name suggests, interact with the Fc region of IgA ... while its Fc region (in the ε heavy chains) binds to Fc receptor ε on a mast cell, triggering its degranulation: the release of ... bind via their Fc receptors (FcR) to the Fc region of an antibody, while the complement system is activated by binding the C1q ...

https://en.wikipedia.org/wiki/Antibody

... and inhibitory signaling pathways mediated by the IgG Fc receptor (Fc gamma RIIB) and the phosphoinositol 5-phosphatase (SHIP ... Ravetch, Jeffrey V.; Bolland, Silvia (April 2001). "IgG Fc Receptors". Annual Review of Immunology. 19 (1): 275-290. doi: ... Bolland, Silvia; Ravetch, Jeffrey V (August 2000). "Spontaneous Autoimmune Disease in FcγRIIB-Deficient Mice Results from ... "Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FeγRIIB". Nature. 383 (6597 ...

https://en.wikipedia.org/wiki/Silvia_Bolland

"Entrez Gene: FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)". The function of Fcγ receptors in dendritic cells ... Ernst LK, van de Winkel JG, Chiu IM, Anderson CL (Aug 1992). "Three genes for the human high affinity Fc receptor for IgG (Fc ... "Definition of interferon gamma-response elements in a novel human Fc gamma receptor gene (Fc gamma RIb) and characterization of ... and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc ...

https://en.wikipedia.org/wiki/FCGR1A

da Silva Junior FC, Araujo RM, Sarmento AS, de Carvalho MM, Fernandes HF, Yoshioka FK, Pinto GR, Motta FJ, Canalle R (December ... The 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled ... derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling ... The 5-HT2A receptor is known primarily to couple to the Gαq signal transduction pathway. Upon receptor stimulation with agonist ...

https://en.wikipedia.org/wiki/5-HT2A_receptor

https://en.wikipedia.org/wiki/Fc_receptor

Structural basis of pH-dependent antibody binding by the neonatal Fc receptor.. Vaughn, D.E., Bjorkman, P.J.. (1998) Structure ... The neonatal Fc receptor (FcRn) mediates the transcytosis of maternal immunoglobulin G (IgG) across fetal and/or neonatal ... The neonatal Fc receptor (FcRn) mediates the transcytosis of maternal immunoglobulin G (IgG) across fetal and/or neonatal ... Crystal Structure at 2.2 A Resolution of the Mhc-Related Neonatal Fc Receptor. Burmeister, W.P., Gastinel, L.N.,& ...

https://www.rcsb.org/structure/3fru

Fc receptor-like protein 2. Names. IFGP family protein 4. SH2 domain containing phosphatase anchor protein 1. fc receptor ... Expression profile of Fc receptor-like molecules in patients with IgA nephropathy. Title: Expression profile of Fc receptor- ... FCRL2 Fc receptor like 2 [Homo sapiens] FCRL2 Fc receptor like 2 [Homo sapiens]. Gene ID:79368 ... This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins ...

https://www.ncbi.nlm.nih.gov/gene/79368

0.05 versus FcγRIIB+/+ control; †. P. , 0.05 versus FcγRIIB+/+ HFD. (. H. ) Following another week of recovery, the mice were ... Here, we have shown that activation of the IgG receptor FcγRIIB in endothelium by hyposialylated IgG plays an important role in ... Beginning at 5 weeks of age, male FcγRIIB+/+ and FcγRIIB-/- mice were fed a control diet (Con) or a HFD for 12 weeks, and BW ( ... Hyposialylated IgG activates endothelial IgG receptor FcγRIIB to promote obesity-induced insulin resistance. ...

https://www.jci.org/articles/view/89333/figure/1

The role of Fc receptors in pathogenesis of age related macular degeneration - Teeling - Fight for Sight. ... The role of Fc receptors in pathogenesis of age related macular degeneration - Teeling - Fight for Sight ...

https://www.southampton.ac.uk/research/projects/the-role-of-fc-receptors-in-pathogenesis-of-age-related-macular-degeneration

We then present new therapeutic avenues specifically targeting Fc gamma receptors (FcγR) as a means to deliver antigen ... These findings go beyond cancer research and may be of relevance for other disease areas that could benefit from FcγR-targeted ... We present an overview of the mechanistic aspects of FcγR-mediated DC targeting, as well as potential tumor vaccination ... and FcγRIIIB+ granulocytes, FcγRIIIA+ natural killer (NK) cells, and FcγRI+ FcγRIIA+ FcγRIIB+ FcγRIIIA+/- monocytes. Critically ...

https://www.mdpi.com/2076-393X/9/4/409

Fcγ-receptors). This phenomenon was transient and apparently confined to the lymphocyte Fcγ-receptor+ve subpopulation. Similar ... The subsequent recovery of these receptors in vivo and in vitro may be due to the binding of fluid-phase Fcγ-receptors found ... In vivo Modulation of Human Lymphocyte Fcγ-Receptors in Response to Oral Antigen (Cows Milk) Challenge Subject Area: ... Detection of Fcγ-Receptor Blocking Antibodies in the Serum following Vaccination International Archives of Allergy and Applied ...

https://karger.com/iai/article-abstract/67/4/344/172917/In-vivo-Modulation-of-Human-Lymphocyte-Fc?redirectedFrom=fulltext

Objective: Fcγ receptor (FcγR) polymorphism influences the affinity of the receptor for Ig, which may, in turn, affect the ... The Fc portion of these biological agents binds specifically to cell surface Fcγ receptors (FcγR) and this may affect their ... Differential binding to human FcγRIIa and FcγRIIb receptors by human IgG wildtype and mutant antibodies. Mol Immunol 2003;40: ... FcγRIIIa-158V/F polymorphism influences the binding of IgG by natural killer cell FcγRIIIa, independently of the FcγRIIIa-48L/R ...

https://ard.bmj.com/content/68/10/1547?ijkey=6c775e8cb0b723c3dbcf618868bba237e5698c16&keytype2=tf_ipsecsha

Thus, Fcγ RIIa-H131R polymorphism was investigated in 493 children who came to a hospital with acute malaria. Variation in Fcγ ... Polymorphic variability in Fcγ RIIa (H/R-131) is associated with differential binding of IgG subtypes and malaria disease ... However, the role of Fcγ RIIa-131 variability in conditioning susceptibility to severe malarial anemia, the primary ... Thus, although homozygosity for the R131 allele protects against high-density parasitemia, FcγRIIa-131 polymorphism does not ...

https://www.ajtmh.org/abstract/journals/tpmd/74/4/article-p573.xml?rskey=xz1lFp&result=1

Uptake is mediated by a mechanism involving the neonatal Fc receptor. Humanized 11B6, which has undergone toxicological tests ... Uptake is mediated by a mechanism involving the neonatal Fc receptor. Humanized 11B6, which has undergone toxicological tests ... Internalization of secreted antigen-targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen ... of secreted antigen-targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis}}, url ...

https://lup.lub.lu.se/search/publication/9d8e09fe-3a87-4bcc-9087-e253cb7c7849

Fc receptor function and circulating immune complexes in gluten sensitive enteropathy--possible significance of serum IgA. ... Fc receptor function and circulating immune complexes in gluten sensitive enteropathy--possible significance of serum IgA. ...

https://gut.bmj.com/content/32/8/876?ijkey=d5497feb5b8a4fad66075a14b6c635139e4f12b5&keytype2=tf_ipsecsha

Antibodies against the extracellular domain of the CAR molecule (anti-Fab, Fc or idiotype) have been used for detection of CAR ... Chimeric Antigen Receptors (CARs) consist of the antigen-recognition portion of a monoclonal antibody fused to an intracellular ... a fusion protein consisting of human CD19 extracellular domains and the Fc region of human IgG1 (CD19sIg). Genes encoding ... Chimeric Antigen Receptors (CARs) consist of the antigen-recognition portion of a monoclonal antibody fused to an intracellular ...

https://escholarship.org/uc/item/5445z91f

Fc epsilon receptors. Detailed annotation on the structure, function, physiology, pharmacology and clinical relevance of drug ... The protein product of the MS4A2 gene is the β subunit of the FCεRI. It has commonly known as FCER1B. The IgE-receptor (FCεRI ... Fc epsilon receptors: membrane spanning 4-domains A2. Last modified on 01/05/2017. Accessed on 02/12/2023. IUPHAR/BPS Guide to ... membrane-spanning 4-domains, subfamily A, member 2 , membrane-spanning 4-domains , APY , FCεR1β , FCεRIβ , IGEL , IGER ...

https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2936

Immunoglobulin-like transcripts are a family of inhibitory and stimulatory cell surface immune receptors. Transcripts for one ... Plasmacytoid dendritic cell-specific receptor ILT7-FcεRIγ inhibits Toll-like receptor-induced interferon production Wei Cao, ... Plasmacytoid dendritic cell-specific receptor ILT7-FcεRIγ inhibits Toll-like receptor-induced interferon production . J Exp Med ... TLR9- and FcεRI-mediated responses oppose one another in plasmacytoid dendritic cells by down-regulating receptor expression. J ...

https://rupress.org/jem/article/203/6/1399/54103/Plasmacytoid-dendritic-cell-specific-receptor-ILT7

We also have observed that Fcγ receptors (FcγR), proteins present on the surface of microglia that bind immunoglobulin G (IgG) ... FcγRs mediate this interaction, and in the absence of the gamma chain, there is altered intracellular trafficking and ... In order to study the role of FcγRs in the interactions of α-SYN and microglia, we treated the primary microglial cultures from ... Therefore, blocking either FcγR signaling or downstream NF-κB activation may be viable therapeutic strategies in PD. ...

https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-9-259

T-cell markers, immunoglobulin and Fc-receptors on AKR thymomas. scientific article published on January 1, 1976 ...

https://m.wikidata.org/wiki/Q43663273

Molecular recognition by Ig-like receptors, KIRs and FcγRs Share Share Share ...

https://www.ndm.ox.ac.uk/publications/25069?e8d7e0ba-6283-11ee-b2eb-0694888955de

Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications. scientific article ...

https://m.wikidata.org/wiki/Q40920376

... is a relatively rare autoimmune disorder in which antibodies form against acetylcholine nicotinic postsynaptic receptors at the ... Efgartigimod alfa is a human IgG1 antibody Fc fragment that binds to neonatal Fc receptor (FcRn), which reduces the circulating ... Other Fc receptor antagonists, efgartigimod/hyaluronidase and rozanolixizumab, [58] have also gained FDA approval. These are ... Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor ...

https://emedicine.medscape.com/article/1171206-treatment

The MHC class I-related receptor, FcRn, is involved in binding and transporting immunoglobulin G (IgG) within and across cells ... Receptors, Fc / chemistry * Receptors, Fc / genetics* * Receptors, Fc / immunology * Receptors, Fc / metabolism* ... Conferring the binding properties of the mouse MHC class I-related receptor, FcRn, onto the human ortholog by sequential rounds ... The MHC class I-related receptor, FcRn, is involved in binding and transporting immunoglobulin G (IgG) within and across cells ...

https://pubmed.ncbi.nlm.nih.gov/15644205/

Unlabelled IgG and IgG Fc fragments inhibited the interaction between 125I-labelled rabbit IgG Fc and the HSV Fc receptor, ... Unlabelled IgG and IgG Fc fragments inhibited the interaction between 125I-labelled rabbit IgG Fc and the HSV Fc receptor, ... Unlabelled IgG and IgG Fc fragments inhibited the interaction between 125I-labelled rabbit IgG Fc and the HSV Fc receptor, ... Unlabelled IgG and IgG Fc fragments inhibited the interaction between 125I-labelled rabbit IgG Fc and the HSV Fc receptor, ...

https://portal.research.lu.se/en/publications/interaction-between-herpes-simplex-type-1-induced-fc-receptor-and

Purchase Recombinant Human Low affinity immunoglobulin gamma Fc region receptor II-c(FCGR2C). It is produced in in vitro E.coli ... Low affinity immunoglobulin gamma Fc region receptor II-c; IgG Fc receptor II-c; CDw32; Fc-gamma RII-c; Fc-gamma-RIIc; FcRII-c ... Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and ... Data show that gains or losses in copy numbers of Fc gamma receptors FCGR3A were less frequent than for FCGR3B and FCGR2C. PMID ...

https://www.cusabio.com/Transmembrane-Protein/Recombinant-Human-Low-affinity-immunoglobulin-gamma-Fc-region-receptor-II-cFCGR2C-11152813.html

title = "Roles of Fc receptors in autoimmunity",. abstract = "The receptors for the Fc of immunoglobulins, Fc receptors (FcRs ... The receptors for the Fc of immunoglobulins, Fc receptors (FcRs), link the humoral and cellular branches of the immune system, ... N2 - The receptors for the Fc of immunoglobulins, Fc receptors (FcRs), link the humoral and cellular branches of the immune ... AB - The receptors for the Fc of immunoglobulins, Fc receptors (FcRs), link the humoral and cellular branches of the immune ...

https://tohoku.elsevierpure.com/en/publications/roles-of-fc-receptors-in-autoimmunity

Fc Receptor Like 5. Product list FCRL5 is a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. ... This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is ...

https://neutab.creative-biolabs.com/symbol-fcrl5-523.htm

... despite exposure of these cells to a deciduogenic stimulus and normal progesterone receptor expression. These molecular ... Steroid receptor coactivator-3 (SRC-3; also known as NCOA3 or AIB1) is a member of the multifunctional p160/SRC family of ... Steroid receptor coactivator-3 is a member of the multifunctional p160/SRC family of coactivators, which also includes SRC-1 ... Jeong JW, Kwak I, Lee KY, White LD, Wang XP, Brunicardi FC, et al. The genomic analysis of the impact of steroid receptor ...

https://www.frontiersin.org/articles/10.3389/frph.2022.1033581/full

The Old but New IgM Fc Receptor (FcµR). F.J. Li, W.J. Won, E.J. Becker Jr., J.L. Easlick, E. Tabengwa, R. Li, M. Shakhmatov, P. ... Fc Receptors as Adaptive Immunoreceptors. Jerrard M Hayes, Eoin FJ Cosgrave, Weston B Struwe, Mark Wormald, Gavin P. Davey, Roy ... Download instantly Fc Receptors by Marc Daeron, Falk Nimmerjahn. It is ebook in PDF format. ... Fc receptor dependent mechanisms of monoclonal antibody therapy of cancer; professionals at work ...

https://booksdo.com/library/ebook-fc-receptors-by-marc-daeron-falk-nimmerjahn/

These data indicate that high-affinity Fc receptors are expressed on less mature monocytes and that FcɛRIα(+) monocytes are ... The profiles were compared to that of subsets defined by the high-affinity IgE receptor (FcɛRIα), CD16, and CD14; further ... The expression of CD64, the high-affinity IgG receptor, on canonical human monocyte subsets was determined before and after ... These data indicate that high-affinity Fc receptors are expressed on less mature monocytes and that FcɛRIα(+) monocytes are ...

https://www.kennedy.ox.ac.uk/publications/581009?82bd21dc-616b-11ee-97a6-06ee384a3ad0

GABA A Receptor alpha 2/GABRA2 (6). * GABA A Receptor beta 2/GABRB2+GABA A Receptor beta 3/GABRB3+GABA A Receptor gamma 2/ ... Fc tag (16). * proprietary tag (14). * His-DHFR tag (3). * DDDDK tag (2). ... Metabotropic glutamate receptor (27). * Metabotropic Glutamate Receptor 2/MGLUR2+Metabotropic Glutamate Receptor 3/MGLUR3 (13) ... Mu Opioid Receptor (13). * Muscarinic Acetylcholine Receptor 2/CM2+Muscarinic Acetylcholine Receptor 1/CHRM1+Muscarinic Acetylc ...

https://www.abcam.com/products?selected.researchAreas=Neuroscience--Neurotransmission--Receptors+%2F+Channels

... receptor nativo de protocolo Bayang incorporado para Tiny Whoop Micro FPV Racing Drone Especificaciones: Nombre del artículo: ... Makerfire Whoop Lite FC controlador de vuelo cepillado compatible con firmware Sliverware, ... Makerfire Whoop Lite FC controlador de vuelo cepillado compatible con firmware Sliverware, receptor nativo de protocolo Bayang ... Protocolo del receptor: protocolo Bayang. Cable de alimentación: 50 mm, con conector JST-PH 2.0. Peso: aproximadamente 2,7 g. ...

https://shop.makerfire.com/es/products/makerfire-whoop-lite-fc-built-in-bayang-protocol-recevier

2) We identified FcγRIIC as a second FcγR on human B cells besides FcγRIIB. Its expression is determined by a single nucleotide ... In this work, we uncovered two new mechanisms that contribute to B cell regulation: Fcγ receptors boosting soluble BLyS levels ... co-ligation of FcγRIIC and BCR led to FcγRIIC tyrosine phosphorylation, as well as enhanced B cell activation, reflected by ... we ii demonstrated that this effect was preferentially mediated by FcγRI compared to FcγRIIA. ( ...

https://digitalcommons.library.uab.edu/etd-collection/228/

However, since this Fc receptor is also involved in transferring IgG from a mother either via the placenta to her fetus or in milk to her suckling infant, it is called the neonatal Fc receptor (FcRn). (wikipedia.org)
We report the three-dimensional structure of human neonatal Fc receptor (FcRn) bound concurrently to its two known ligands. (nih.gov)
Immunoglobulin G (IgG) and the neonatal Fc receptor for IgG (FcRn) have an important function in the mucosal immune system that we have now shown extends to the induction of CD8+ T cell-mediated antitumor immunity. (harvard.edu)
In young mice, Aβ-anti-Aβ complexes were cleared from brain to blood by transcytosis across the BBB via the neonatal Fc receptor (FcRn) and the low-density lipoprotein receptor-related protein (LRP), whereas in older mice, there was an age-dependent increase in FcRn-mediated IgG-assisted Aβ BBB efflux and a decrease in LRP-mediated clearance of Aβ-anti-Aβ complexes. (nih.gov)
This security was influenced by the appearance of FcγR as well as the neonatal Fc receptor (FcRn) as immunization of FcγR- or FcRn-deficient mice or i.n. administration of F(ab′)2 MAb-iFT ICs abrogated security (2). (healthandwellnesssource.org)
In this thesis, rational design principles have been used for development of fusion proteins that can interact with the neonatal Fc receptor (FcRn) for potential medical applications. (kth.se)

Fc receptors bind to antibodies that are attached to infected cells or invading pathogens. (wikipedia.org)
Antibodies produced in response to a foreign antigen are characterized by polyclonality, not only in the diverse epitopes to which their variable domains bind but also in the various effector molecules to which their constant regions (Fc domains) engage. (nature.com)
This review will discuss current understanding of how antibodies and their receptors can be brought to bear on proteins involved in neurodegeneration. (frontiersin.org)
Common mechanisms that may contribute to protection against self-propagating protein conformations include blocking the entry of protein "seeds" to cells, clearance of immune complexes by microglia, and the intracellular protein degradation pathway initiated by cytoplasmic antibodies via the Fc receptor TRIM21. (frontiersin.org)
Most of these immunomodulatory antibodies are of IgG isotypes that have low, or no, binding to the Fc gamma receptors (FcγRs) that trigger cell-mediated cytotoxic effector functions such as antibody dependent cellular cytotoxicity (ADCC) and phagocytosis (ADCP). (bmj.com)
However, recent preclinical data highlight a potential role for FcγR engagement in the activity of such antibodies. (bmj.com)
Here we review the biology of the FcγRs and IgG isotypes in both humans and mice, detail the potential roles that FcγR interactions can play in the activity of monoclonal antibodies in general, and of immunomodulatory antibodies in particular, and discuss how preclinical studies on these interactions might be best interpreted and translated to a human setting. (bmj.com)
Antibodies of the IgG sub-class are bi-functional molecules, possessing a F(ab) domain, variable in sequence and responsible for the binding of antigen, and an Fc domain, constant in sequence and responsible for mediating a range of antibody effector functions [ 1 ]. (bmj.com)
We demonstrate that pig Fc receptors do not bind human IgG1 and that FI6 did not mediate antibody-dependent cytotoxicity (ADCC) with pig PBMC, confirming that ADCC is an important mechanism of protection by anti-stem antibodies in vivo. (pirbright.ac.uk)
Within the disciplines of cellular biology, a receptor is a protein molecule found embedded in the plasma membrane of, or within the nucleus or cytoplasm of, a cell that functions as a primary initiator of intercellular communications by selective binding and responding to specific factors, including: cytokines, antigens, antibodies, hormones, neurotransmitters, and other cellular or immunological ligands. (peprotech.com)
Dozens of BCMA-targeting therapies, such as antibody-drug conjugate, Bi-specific antibodies, and chimeric antigen receptor T (CAR-T) cells are presently being created and tested clinically. (news-medical.net)
however, the vaccine induced different Fc-receptor-binding antibodies across groups. (bvsalud.org)
Differential antibody binding to FcÎ³R3B was linked to Fc- glycosylation differences in SARS-CoV-2 -specific antibodies . (bvsalud.org)
Human Fc gamma receptor IIB (FcγRIIB, CD32b) His+Avi (Biotinylated) is used to measure the affinity of antibodies for it. (genemedi.net)
The Fc receptor binding assay (Competitive ELISA immunoassay, SRP assay or BLI assay) plays a vital role in the development of therapeutic antibodies. (genemedi.net)
Additionally, antibodies can clear infected cells or immune complex through interaction of the antibody Fc region with host proteins, such as Fc receptors. (nih.gov)

Its name is derived from its binding specificity for a part of an antibody known as the Fc (fragment crystallizable) region. (wikipedia.org)
Some viruses such as flaviviruses use Fc receptors to help them infect cells, by a mechanism known as antibody-dependent enhancement of infection. (wikipedia.org)
There are several different types of Fc receptors (abbreviated FcR), which are classified based on the type of antibody that they recognize. (wikipedia.org)
The Latin letter used to identify a type of antibody is converted into the corresponding Greek letter, which is placed after the 'Fc' part of the name. (wikipedia.org)
For example, those that bind the most common class of antibody, IgG, are called Fc-gamma receptors (FcγR), those that bind IgA are called Fc-alpha receptors (FcαR) and those that bind IgE are called Fc-epsilon receptors (FcεR). (wikipedia.org)
This family includes several members, FcγRI (CD64), FcγRIIA (CD32), FcγRIIB (CD32), FcγRIIIA (CD16a), FcγRIIIB (CD16b), which differ in their antibody affinities due to their different molecular structure. (wikipedia.org)
Another FcR is expressed on multiple cell types and is similar in structure to MHC class I. This receptor also binds IgG and is involved in preservation of this antibody. (wikipedia.org)
Another receptor can also bind IgA, although it has higher affinity for another antibody called IgM. (wikipedia.org)
These conformational states are regulated by the differences among antibody subclasses in their amino acid sequence and by the complex, biantennary Fc-associated N -linked glycan. (nature.com)
Consider treatment with eculizumab for patients who are anti-acetylcholine receptor antibody-positive refractory. (medscape.com)
Further characterization of infection revealed that the antibody enhanced infection is dependent upon antibody binding to the FC gamma II receptor/CD32 and virus simultaneously. (nih.gov)
Engineered crystallizable fragment (Fc) regions of antibody domains, which assume a unique and unprecedented asymmetric structure within the homodimeric Fc polypeptide, enable completely selective binding to the complement component C1q and activation of complement via the classical pathway without any concomitant engagement of the Fc? (tdl.org)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Receptor II For The Fc Region Of Immunoglobulin E (FceRII) in serum, plasma, tissue homogenates, cell lysates and other biological fluids. (lipidx.org)
It works by reducing the amount of IgG (an antibody that attacks neuromuscular receptors in patients with myasthenia gravis) circulating in the body. (medlineplus.gov)
Antibody Fc interactions can also modulate the innate and adaptive immune response. (nih.gov)
Indeed, Fc-Fc gamma receptor interactions have been shown to be required for optimal monoclonal antibody therapy during alphavirus infections. (nih.gov)

More particularly, we solved the crystal structure of the complex between human FcRn, wild-type human serum albumin (HSA), and a human Fc engineered for improved pharmacokinetics properties (Fc-YTE). (nih.gov)
At last, this study also allows an accurate structural definition of residues considered for decades as important to the human IgG/FcRn interaction and reveals Fc His(310) as a significant contributor to pH-dependent binding. (nih.gov)
Finally, we explain various structural mechanisms by which several Fc mutations (including YTE) result in increased human IgG binding to FcRn. (nih.gov)
Our study provides an unprecedented relevant understanding of the molecular basis of human Fc interaction with human FcRn. (nih.gov)
They had the expected binding abilities to FcRn, SA and hGH receptor. (kth.se)

Recent evidence points to a crucial in vivo role of Fc gamma R in both initiation and regulation of inflammatory and cytotoxic responses. (nih.gov)

We constructed a soluble minimal receptor-Ig chimera in which the two extracellular domains of human FcεRI α-chain (D1 and D2) were fused to the dimerizing C-terminal domain of human IgG1 heavy chain (γ1-CH3). (unipv.it)
The receptor-Ig chimera, in 2-fold molar excess, inhibited engagement of secretory IgE to rat basophilic leukemia cells expressing the human αβγ receptor. (unipv.it)
Soluble FGFR3 Human recombinant fused using a Xa cleavage site with the Fc part of human IgG1 produced in Fc Chimera is a heterodimeric, glycosylated, Polypeptide chain containing 593aa and having a molecular mass of 170kDa. (prospecbio.com)

The receptor has been classified based on its affinity for IgG1, IgG3, IgG4. (genemedi.net)

All of the Fcγ receptors (FcγR) belong to the immunoglobulin superfamily and are the most important Fc receptors for inducing phagocytosis of opsonized (marked) microbes. (wikipedia.org)
FcγRI also has an extracellular portion composed of three immunoglobulin (Ig)-like domains, one more domain than FcγRII or FcγRIII has. (wikipedia.org)
It is composed of two extracellular Ig-like domains, and is a member of both the immunoglobulin superfamily and the multi-chain immune recognition receptor (MIRR) family. (wikipedia.org)
With one Ig-like domain in its extracellular portion, this Fc receptor is also a member of the immunoglobulin superfamily. (wikipedia.org)
Two types of FcεR are known: the high-affinity receptor FcεRI is a member of the immunoglobulin superfamily (it has two Ig-like domains). (wikipedia.org)
Differentiation of species in human beta-haemolytic group G streptococci using immunoglobulin Fc fragment receptor. (bmj.com)
Description: A sandwich ELISA kit for detection of Receptor II For The Fc Region Of Immunoglobulin E from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (lipidx.org)
Description: A sandwich quantitative ELISA assay kit for detection of Human Receptor II For The Fc Region Of Immunoglobulin E (FceRII) in samples from serum, plasma or other biological fluids. (lipidx.org)
The Fc receptor is expressed on many immune cells and binds to the specific immunoglobulin, then modulating the immune response. (genemedi.net)

The Fc-gamma receptors differ in their affinity for IgG and likewise the different IgG subclasses have unique affinities for each of the Fc gamma receptors. (wikipedia.org)

In general, the cell's ability to perceive and respond to its surrounding environment begins with external stimulation in the form of an extracellular signaling molecule that binds to a receptor protein, which, in turn, initiates a cascading sequence of biochemical events known as signal transduction. (peprotech.com)
IL-1RAcP consists of an extracellular domain containing three Ig-like C2 type domains, a transmembrane region and a cytoplasmic portion with a TIR (Toll-IL-1-receptor) domain. (biolegend.com)

For instance, FcγRI binds to IgG more strongly than FcγRII or FcγRIII does. (wikipedia.org)
Moreover, the dimeric receptor binds IgE with the expected 1:2 stoichiometry. (unipv.it)
First-generation antihistamine that binds to H1 receptors in the CNS and the body. (medscape.com)

Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. (creativebiomart.net)

These signaling pathways can also include the further participation of intracellular receptors found immersed within the cytoplasm or nucleus of the cell that bind secondary messenger molecules, and in turn enable a various cooperative interactions between multiple signaling pathways in order to achieve appropriate cellular responses to complex combinations of signaling stimuli. (peprotech.com)
The interactions between BAFF/APRIL and their receptors are selective. (news-medical.net)

This property allows FcγRI to bind a sole IgG molecule (or monomer), but all Fcγ receptors must bind multiple IgG molecules within an immune complex to be activated. (wikipedia.org)

IgG Fc Domains that Bind C1q but not Effector Fc? (tdl.org)
No. BAF-H4268) at 5 μg/mL (100 μL/well) can bind Biotinylated Human BCMA, Fc Tag (Cat. (news-medical.net)
Full self-nature and inability to bind Fcγ receptors make this protein an attractive candidate for clinical applications and a novel biotechnological tool for atopic allergy research. (unipv.it)

the low-affinity receptor FcεRII (CD23) is a C-type lectin. (wikipedia.org)

Human IgG receptors constitute a family of glycoprotein complexes consisting of ligand-binding, and associated signaling chains. (nih.gov)
RESULTS: The FcγRIIIa-66L/R/H (rs10127939) polymorphism influenced ligand binding capacity in the presence of the FcγRIIIa-176V (rs396991) allele. (nih.gov)
CONCLUSION: FcγRIIIa-66L/R/H influences ligand binding. (nih.gov)
The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). (creativebiomart.net)
Upon ligand binding to IL-1R1, IL-1RAcP is recruited to form a high affinity heterodimeric receptor complex. (biolegend.com)

These functions are primarily triggered through interaction with the complement component C1q or with a family of FcγRs expressed, primarily, on the surface of leukocytes. (bmj.com)
receptors delineate the importance of complement-mediated effector functions. (tdl.org)

Here we discuss the diverse downstream proinflammatory, anti-inflammatory and immunomodulatory consequences of the engagement of type I and type II Fc receptors in the context of infectious, autoimmune, and neoplastic disorders. (nature.com)
Figure 1: Reciprocal engagement of type I and type II FcRs by the IgG Fc domain. (nature.com)
and 2) determine the functional profiles of Fc receptor engagement in the context of immune responses elicited by protective vaccines, to inform advancement of similarly promising HIV vaccine candidates. (nih.gov)
In addition, membrane-bound IL-1R2 inhibits IL-1 signaling by sequestering IL-1 and IL-1RAcP, limiting the availability of IL-1RAcP for engagement of receptor complex. (biolegend.com)

The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. (creativebiomart.net)

11. Proline to arginine mutations in FGF receptors 1 and 3 result in Pfeiffer and Muenke craniosynostosis syndromes through enhancement of FGF binding affinity. (nih.gov)
13. Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers. (nih.gov)

Three leukocyte classes (Fc gamma RI, II, and III) and one separate endothelial Fc gamma R class (FcRB) are defined which are expressed on hematopoietic and endothelial cells. (nih.gov)

Fc receptors are found on a number of cells in the immune system including phagocytes like macrophages and monocytes, granulocytes like neutrophils and eosinophils, and lymphocytes of the innate immune system (natural killer cells) or adaptive immune system (e.g. (wikipedia.org)

FcαRI is found on the surface of neutrophils, eosinophils, monocytes, some macrophages (including Kupffer cells), and some dendritic cells. (wikipedia.org)

As a result of its cellular distribution, this receptor plays a major role in controlling allergic responses. (wikipedia.org)
Each IgG isotype has a different binding profile to the various FcγRs, and each FcγR has a different cellular expression pattern. (bmj.com)
Numerous studies have demonstrated that targeting Ag to Fc receptors (FcR) on APCs can enhance humoral and cellular immunity. (umassmed.edu)
We investigated a novel antagonist of the prolactin receptor in vitro and found that it could block signaling through the receptor as well as cellular invasiveness. (kth.se)
15. Cellular signaling by fibroblast growth factor receptors. (nih.gov)

FcεRI is also expressed on antigen-presenting cells, and controls the production of important immune mediators called cytokines that promote inflammation. (wikipedia.org)
Because of this researchers have used novel ways of focus on antigens (Ags) to receptors portrayed on the areas of antigen-presenting cells (APCs) such as for example dendritic cells (DCs) and macrophages in order to RWJ-67657 better activate the mucosal disease fighting capability and elicit solid and protective immune system responses (1). (healthandwellnesssource.org)

For example, by creating steric hindrance, fucose containing CH2-84.4 glycans reduce IgG affinity for FcγRIIIA. (wikipedia.org)
In contrast, G0 glycans, which lack galactose and terminate instead with GlcNAc moieties, have increased affinity for FcγRIIIA. (wikipedia.org)

Recombinant Mouse Activin Receptor IB is produced by our Mammalian expression system and the target gene encoding Leu32-Glu126 is expressed with a Fc tag at the C-terminus. (bonopusbio.com)
4. Localisation and differential expression of the fibroblast growth factor receptor (FGFR) multigene family in normal and atherosclerotic human arteries. (nih.gov)

Multiple studies have shown that Fc-dependent mechanisms are essential for FI6 in vivo efficacy. (pirbright.ac.uk)
Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms. (nih.gov)

20. A soluble dominant negative fibroblast growth factor receptor 4 isoform in human MCF-7 breast cancer cells. (nih.gov)

These results demonstrate that IVIgG attenuates asthmatic features and the function of lung CD11c + DCs via Fcg receptor IIb in allergic airway inflammation. (elsevierpure.com)

Nimmerjahn, F. & Ravetch, J.V. Fc-receptors as regulators of immunity. (nature.com)

Susceptibility to dengue hemorrhagic fever in vietnam: evidence of an association with variation in the vitamin d receptor and Fc gamma receptor IIa genes. (ox.ac.uk)
Four distinct genes encoding closely related FGF receptors, FGFR-1to -4 are known. (prospecbio.com)

These Fc gamma R-mediated immune responses can be exploited to develop novel immunotherapies. (nih.gov)
Nimmerjahn, F. & Ravetch, J.V. Fcγ receptors as regulators of immune responses. (nature.com)

Diversity and duplicity: human Fcγ receptors in host defense and autoimmunity. (nature.com)
Fcγ receptor IIIa single-nucleotide polymorphisms and haplotypes affect human IgG binding and are associated with lupus nephritis in African Americans. (nih.gov)
METHODS: FcγRIIIa variants, expressed on A20 IIA1.6 cells, were used in flow cytometry-based human IgG-binding assays. (nih.gov)
Immobilized Human BAFF, Fc Tag (Cat. (news-medical.net)
16. Identification of a novel variant form of fibroblast growth factor receptor 3 (FGFR3 IIIb) in human colonic epithelium. (nih.gov)
GeneMedi provides two kinds of Human Fc gamma receptor IIB (FcγRIIB, CD32b)(GMP-BioFcR-ag-009), GMP-BioFcR-ag-009-1 is with the tag His and Avi, GMP-BioFcR-ag-009-2 is Biotinylated and also with the tag His and Avi. (genemedi.net)

Targeting Fc portions of IgG and Fcγ receptor IIb on CD11c + DCs in allergic asthma is a promising therapeutic strategy. (elsevierpure.com)
These agents decrease or prevent allergic symptoms caused by histamine receptors from mast cells. (medscape.com)

The classes of FcR's are also distinguished by the cells that express them (macrophages, granulocytes, natural killer cells, T and B cells) and the signalling properties of each receptor. (wikipedia.org)
FcεRI is found on epidermal Langerhans cells, eosinophils, mast cells and basophils. (wikipedia.org)
Fc gamma receptor IIb modulates the molecular Grb2 interaction network in activated B cells. (mpg.de)
Next, to analyse the effects on Fcg receptor IIb and dendritic cells (DCs), asthmatic features in Fcg receptor IIb-deficient mice were analysed. (elsevierpure.com)
In study I and II, the prolactin receptor was found to often be expressed in glioblastoma multiforme tumors from patients as well as in glioblastoma multiforme cells lines. (kth.se)

Figure 2: Glycan-dependent modulation of Fc structure. (nature.com)
Anthony, R.M. & Ravetch, J.V. A novel role for the IgG Fc glycan: the anti-inflammatory activity of sialylated IgG Fcs. (nature.com)

Nephritis among African American patients with SLE was associated with FcγRIIIa low-binding haplotypes containing the 66L/R/H and 176F variants (P = 0.03) and with low-binding genotype combinations (P = 0.002). (nih.gov)

The produced fusion protein was found to be able to block signaling through the prolactin receptor in vitro and also had a prolonged plasma half-life in vivo . (kth.se)

This gene encodes a receptor tyrosine kinase. (nih.gov)
Fc receptor-like ( FCRL ) gene family a new member of the Ig superfamily, which encodes the protein may play an essential role in regulating B signaling [ 9 ]. (biomedcentral.com)

The 3rd Fc Receptor Pathway Targeted Therapies Summit will once again feature unmissable conversations to advance targeting FcR and the subsequent generation of Fc manipulation since real-world proof and clinical value are now at the industry's fingertips. (biointron.com)
10. Fibroblast growth factor receptor signaling in hereditary and neoplastic disease: biologic and clinical implications. (nih.gov)

OBJECTIVE: To investigate whether the Fcγ receptor IIIa-66L/R/H (FcγRIIIa-66L/R/H) polymorphism influences net effective receptor function and to assess if the FCGR3A combined genotypes formed by FcγRIIIa-66L/R/H and FcγRIIIa-176F/V, as well as copy number variation (CNV), confer risk of developing systemic lupus erythematosus (SLE) and lupus nephritis. (nih.gov)

This receptor is called the Fc-alpha/mu receptor (Fcα/μR) and is a type I transmembrane protein. (wikipedia.org)
9. Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans. (nih.gov)

We selected most pathways IL5RA participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, which may be useful for your reference. (creativebiomart.net)

Upon interaction with IgG, Fc gamma R initiate a plethora of signaling cascades involving receptor signaling motifs, and protein tyrosine kinases and phosphatases. (nih.gov)

Anatomy2

Chemicals and Drugs4

Phenomena and Processes3

Information Science1

Characterization of the interaction between the herpes simplex virus type I Fc receptor and immunoglobulin G. (1/2162)

Alternative endocytic pathway for immunoglobulin A Fc receptors (CD89) depends on the lack of FcRgamma association and protects against degradation of bound ligand. (2/2162)

Fc receptor beta subunit is required for full activation of mast cells through Fc receptor engagement. (3/2162)

Nonvectorial surface transport, endocytosis via a Di-leucine-based motif, and bidirectional transcytosis of chimera encoding the cytosolic tail of rat FcRn expressed in Madin-Darby canine kidney cells. (4/2162)

Modulation of the humoral immune response by antibody-mediated antigen targeting to complement receptors and Fc receptors. (5/2162)

Human mesangial cells in culture and in kidney sections fail to express Fc alpha receptor (CD89). (6/2162)

B lymphocytes as antigen-presenting cells for CD4+ T cell priming in vivo. (7/2162)

Improving the efficacy of antibody-interleukin 2 fusion proteins by reducing their interaction with Fc receptors. (8/2162)

Receptors, IgG

Receptors, IgE

Receptors, Fc

Immunoglobulin Fc Fragments

Antibody-Dependent Enhancement

Encyclopedias as Topic

Antibody-Dependent Cell Cytotoxicity

Phagocytosis

Killer Cells, Natural

Dendritic Cells, Follicular

Characterization of the interaction between the herpes simplex virus type I Fc receptor and immunoglobulin G. (1/2162)

Alternative endocytic pathway for immunoglobulin A Fc receptors (CD89) depends on the lack of FcRgamma association and protects against degradation of bound ligand. (2/2162)

Fc receptor beta subunit is required for full activation of mast cells through Fc receptor engagement. (3/2162)

Nonvectorial surface transport, endocytosis via a Di-leucine-based motif, and bidirectional transcytosis of chimera encoding the cytosolic tail of rat FcRn expressed in Madin-Darby canine kidney cells. (4/2162)

Modulation of the humoral immune response by antibody-mediated antigen targeting to complement receptors and Fc receptors. (5/2162)

Human mesangial cells in culture and in kidney sections fail to express Fc alpha receptor (CD89). (6/2162)

B lymphocytes as antigen-presenting cells for CD4+ T cell priming in vivo. (7/2162)

Improving the efficacy of antibody-interleukin 2 fusion proteins by reducing their interaction with Fc receptors. (8/2162)

Fc receptor

Neonatal Fc receptor

Fc receptor-like molecule

5-HT1A receptor

Death receptor 4

Decoy receptor 1

Decoy receptor 2

Coagulation factor II receptor

Death receptor 5

Κ-opioid receptor

T cell receptor T cell therapy

Killer activation receptor

Low-affinity nerve growth factor receptor

Adenosine A2A receptor

Fibroblast growth factor receptor 3

5-HT receptor

Muscarinic acetylcholine receptor M2

Interleukin-13 receptor

Type I cytokine receptor

Dopamine receptor D3

Poliovirus receptor-related 1

Glucagon-like peptide-1 receptor agonist

Nociceptin receptor

Non-catalytic tyrosine-phosphorylated receptor

Collagen receptor

Interleukin 13 receptor, alpha 1

Antibody

Silvia Bolland

FCGR1A

5-HT2A receptor

Fc receptor - Wikipedia

RCSB PDB - 3FRU: NEONATAL FC RECEPTOR, PH 6.5

FCRL2 Fc receptor like 2 [Homo sapiens (human)] - Gene - NCBI

JCI - Hyposialylated IgG activates endothelial IgG receptor FcγRIIB to promote obesity-induced insulin resistance

The role of Fc receptors in pathogenesis of age related macular degeneration - Teeling - Fight for Sight | University of...

Vaccines | Free Full-Text | Dendritic Cell Tumor Vaccination via Fc Gamma Receptor Targeting: Lessons Learned from Pre-Clinical...

In vivo Modulation of Human Lymphocyte Fcγ-Receptors in Response to Oral Antigen (Cows' Milk) Challenge | International...

Influence of variants of Fcγ receptors IIA and IIIA on the American College of Rheumatology and European League Against...

ASSOCIATION OF FCγ RECEPTOR IIA (CD32) POLYMORPHISM WITH MALARIAL ANEMIA AND HIGH-DENSITY PARASITEMIA IN INFANTS AND YOUNG...

Internalization of secreted antigen-targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen...

Fc receptor function and circulating immune complexes in gluten sensitive enteropathy--possible significance of serum IgA. | Gut

A CD19/Fc fusion protein for detection of anti-CD19 chimeric antigen receptors.

membrane spanning 4-domains A2 | Fc epsilon receptors | IUPHAR/BPS Guide to PHARMACOLOGY

Plasmacytoid dendritic cell-specific receptor ILT7-FcεRIγ inhibits Toll-like receptor-induced interferon production | Journal...

The gamma chain subunit of Fc receptors is required for alpha-synuclein-induced pro-inflammatory signaling in microglia |...

Murine thymic lymphomas as model tumors for T-cell studies. T-cell markers, immunoglobulin and Fc-receptors on AKR thymomas -...

Molecular recognition by Ig-like receptors, KIRs and FcγRs - Nuffield Department of Medicine

Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications - Wikidata

Myasthenia Gravis Treatment & Management: Approach Considerations, Pharmacologic Therapy, Management of neonatal myasthenia...

Conferring the binding properties of the mouse MHC class I-related receptor, FcRn, onto the human ortholog by sequential rounds...

Interaction between herpes simplex type 1-induced Fc receptor and human and rabbit immunoglobulin G (IgG) domains<...

Recombinant Human Low affinity immunoglobulin gamma Fc region receptor II-c(FCGR2C) - Cusabio

Roles of Fc receptors in autoimmunity<...

Fc Receptor Like 5 - Creative Biolabs

Frontiers | Decidualization of human endometrial stromal cells requires steroid receptor coactivator-3

eBook) Fc Receptors by Marc Daeron, Falk Nimmerjahn | Booksdo.com

High-Affinity Fc Receptor Expression Indicates Relative Immaturity in Human Monocytes. - The Kennedy Institute of Rheumatology

Results for 'Receptors / Channels' | Abcam: antibodies, proteins, kits...

Makerfire Whoop Lite FC incorporado Protocolo Bayang Receptor

"Regulation of B Cell Biology by FCγ Receptors" by Xinrui Li

Neonatal Fc recep6

Antibodies16