Saturated quinolizines that are two fused six-membered rings with a nitrogen atom at the ring fusion. They are biosynthesized in PLANTS by cyclization of a LYSINE coupled to CADAVERINE. Many of them are naturally occurring ALKALOIDS.
Saturated indolizines that are fused six and five-membered rings with a nitrogen atom at the ring fusion. They are biosynthesized in PLANTS by cyclization of a LYSINE coupled to ACETYL COENZYME A. Many of them are naturally occurring ALKALOIDS.

Indolizidine 239Q and quinolizidine 275I. Major alkaloids in two Argentinian bufonid toads (Melanophryniscus). (1/12)

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Total synthesis of the alpha-glucosidase inhibitors schulzeine A, B, and C and a structural revision of schulzeine A. (2/12)

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A convergent stereoselective synthesis of quinolizidines and indolizidines: chemoselective coupling of 2-hydroxymethyl-substituted allylic silanes with imines. (3/12)

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A hybrid indoloquinolizidine peptide as allosteric modulator of dopamine D1 receptors. (4/12)

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ETM-ANN approach application for thiobenzamide and quinolizidine derivatives. (5/12)

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Stereoselective synthesis of the eastern quinolizidine portion of himeradine A. (6/12)

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Expedient enantioselective synthesis of cermizine D. (7/12)

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Lysine decarboxylase catalyzes the first step of quinolizidine alkaloid biosynthesis and coevolved with alkaloid production in leguminosae. (8/12)

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Quinolizidines are not typically referred to in the context of medical definitions. They are a type of organic compound that consists of a fully saturated, nitrogen-containing ring structure with eight members. These compounds are primarily found in certain plants, particularly in the Leguminosae family (also known as Fabaceae or the pea family).

Quinolizidine alkaloids are natural substances produced by these plants and can have various pharmacological effects on animals and humans. Some of these alkaloids may have medicinal properties, while others can be toxic. For instance, some quinolizidine alkaloids found in plants like lupines can cause poisoning if ingested in large quantities.

While not a medical definition per se, it is worth noting that quinolizidines might appear in the context of pharmacology or toxicology due to their presence in certain medicinal plants and potential effects on human health.

Indolizidines are a type of heterocyclic organic compound that contains a five-membered ring fused to a six-membered ring, with one nitrogen atom and one carbon atom common to both rings. The structure of indolizidine is similar to that of the naturally occurring alkaloids, which are found in various plants and animals and have diverse biological activities.

Indolizidines can be synthesized in the laboratory and have been studied for their potential therapeutic uses, such as anti-inflammatory, antiviral, and insecticidal properties. However, they can also have toxic effects and may interact with other drugs or chemicals in the body.

It is important to note that indolizidines are not a medical term per se, but rather a chemical classification of a specific type of organic compound.

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