Genetic loci associated with a QUANTITATIVE TRAIT.
A characteristic showing quantitative inheritance such as SKIN PIGMENTATION in humans. (From A Dictionary of Genetics, 4th ed)
Any method used for determining the location of and relative distances between genes on a chromosome.
Deliberate breeding of two different individuals that results in offspring that carry part of the genetic material of each parent. The parent organisms must be genetically compatible and may be from different varieties or closely related species.
A phenotypically recognizable genetic trait which can be used to identify a genetic locus, a linkage group, or a recombination event.
The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME.
Complex nucleoprotein structures which contain the genomic DNA and are part of the CELL NUCLEUS of MAMMALS.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
A form of gene interaction whereby the expression of one gene interferes with or masks the expression of a different gene or genes. Genes whose expression interferes with or masks the effects of other genes are said to be epistatic to the effected genes. Genes whose expression is affected (blocked or masked) are hypostatic to the interfering genes.
Animals that are produced through selective breeding to eliminate genetic background differences except for a single or few specific loci. They are used to investigate the contribution of genetic background differences to PHENOTYPE.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
The mating of plants or non-human animals which are closely related genetically.
The total relative probability, expressed on a logarithmic scale, that a linkage relationship exists among selected loci. Lod is an acronym for "logarithmic odds."
Complex nucleoprotein structures which contain the genomic DNA and are part of the CELL NUCLEUS of PLANTS.
Genotypic differences observed among individuals in a population.
A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs).
The production of offspring by selective mating or HYBRIDIZATION, GENETIC in animals or plants.
Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.
A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.
The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.
Nonrandom association of linked genes. This is the tendency of the alleles of two separate but already linked loci to be found together more frequently than would be expected by chance alone.
A phenotypic outcome (physical characteristic or disease predisposition) that is determined by more than one gene. Polygenic refers to those determined by many genes, while oligogenic refers to those determined by a few genes.
An analysis comparing the allele frequencies of all available (or a whole GENOME representative set of) polymorphic markers in unrelated patients with a specific symptom or disease condition, and those of healthy controls to identify markers associated with a specific disease or condition.
Mouse strains constructed to possess identical genotypes except for a difference at a single gene locus.
The functional hereditary units of PLANTS.
Annual cereal grass of the family POACEAE and its edible starchy grain, rice, which is the staple food of roughly one-half of the world's population.
Mapping of the linear order of genes on a chromosome with units indicating their distances by using methods other than genetic recombination. These methods include nucleotide sequencing, overlapping deletions in polytene chromosomes, and electron micrography of heteroduplex DNA. (From King & Stansfield, A Dictionary of Genetics, 5th ed)
In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Specific regions that are mapped within a GENOME. Genetic loci are usually identified with a shorthand notation that indicates the chromosome number and the position of a specific band along the P or Q arm of the chromosome where they are found. For example the locus 6p21 is found within band 21 of the P-arm of CHROMOSOME 6. Many well known genetic loci are also known by common names that are associated with a genetic function or HEREDITARY DISEASE.
Functions constructed from a statistical model and a set of observed data which give the probability of that data for various values of the unknown model parameters. Those parameter values that maximize the probability are the maximum likelihood estimates of the parameters.
A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.
Computer-based representation of physical systems and phenomena such as chemical processes.
A plant species of the family POACEAE. It is a tall grass grown for its EDIBLE GRAIN, corn, used as food and animal FODDER.
The genetic process of crossbreeding between genetically dissimilar parents to produce a hybrid.
The genetic complement of a plant (PLANTS) as represented in its DNA.
The different ways GENES and their ALLELES interact during the transmission of genetic traits that effect the outcome of GENE EXPRESSION.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
A theorem in probability theory named for Thomas Bayes (1702-1761). In epidemiology, it is used to obtain the probability of disease in a group of people with some characteristic on the basis of the overall rate of that disease and of the likelihood of that characteristic in healthy and diseased individuals. The most familiar application is in clinical decision analysis where it is used for estimating the probability of a particular diagnosis given the appearance of some symptoms or test result.
The encapsulated embryos of flowering plants. They are used as is or for animal feed because of the high content of concentrated nutrients like starches, proteins, and fats. Rapeseed, cottonseed, and sunflower seed are also produced for the oils (fats) they yield.
Differential and non-random reproduction of different genotypes, operating to alter the gene frequencies within a population.
The discipline studying genetic composition of populations and effects of factors such as GENETIC SELECTION, population size, MUTATION, migration, and GENETIC DRIFT on the frequencies of various GENOTYPES and PHENOTYPES using a variety of GENETIC TECHNIQUES.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
The capacity of an organism to defend itself against pathological processes or the agents of those processes. This most often involves innate immunity whereby the organism responds to pathogens in a generic way. The term disease resistance is used most frequently when referring to plants.
Animals that are generated from breeding two genetically dissimilar strains of the same species.
A phenomenon in which multiple and diverse phenotypic outcomes are influenced by a single gene (or single gene product.)
The genetic constitution of individuals with respect to one member of a pair of allelic genes, or sets of genes that are closely linked and tend to be inherited together such as those of the MAJOR HISTOCOMPATIBILITY COMPLEX.
The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.
The analysis of a sequence such as a region of a chromosome, a haplotype, a gene, or an allele for its involvement in controlling the phenotype of a specific trait, metabolic pathway, or disease.
Diseases of plants.
Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.
Inbred DBA mice are a strain of laboratory mice that are genetically identical and share specific characteristics, including a high incidence of deafness, coat color (black and white), and susceptibility to certain diseases, which make them useful for research purposes in biomedical studies.
A plant genus of the family POACEAE. The EDIBLE GRAIN, barley, is widely used as food.
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
The reproductive organs of plants.
The adaptive superiority of the heterozygous GENOTYPE with respect to one or more characters in comparison with the corresponding HOMOZYGOTE.
Tops of plants when in flower, including the stems, leaves and blooms.
Cultivated plants or agricultural produce such as grain, vegetables, or fruit. (From American Heritage Dictionary, 1982)
The systematic study of the complete DNA sequences (GENOME) of organisms.
The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.
The proportion of one particular in the total of all ALLELES for one genetic locus in a breeding POPULATION.
In statistics, a technique for numerically approximating the solution of a mathematical problem by studying the distribution of some random variable, often generated by a computer. The name alludes to the randomness characteristic of the games of chance played at the gambling casinos in Monte Carlo. (From Random House Unabridged Dictionary, 2d ed, 1993)
Animals produced by the mating of progeny over multiple generations. The resultant strain of animals is virtually identical genotypically. Highly inbred animal lines allow the study of certain traits in a relatively pure form. (Segen, Dictionary of Modern Medicine, 1992)
Inbred C57BL mice are a strain of laboratory mice that have been produced by many generations of brother-sister matings, resulting in a high degree of genetic uniformity and homozygosity, making them widely used for biomedical research, including studies on genetics, immunology, cancer, and neuroscience.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.
A plant species of the family BRASSICACEAE best known for the edible roots.
A plant genus of the family POACEAE that is the source of EDIBLE GRAIN. A hybrid with rye (SECALE CEREALE) is called TRITICALE. The seed is ground into FLOUR and used to make BREAD, and is the source of WHEAT GERM AGGLUTININS.
A plant genus of the family BRASSICACEAE that contains ARABIDOPSIS PROTEINS and MADS DOMAIN PROTEINS. The species A. thaliana is used for experiments in classical plant genetics as well as molecular genetic studies in plant physiology, biochemistry, and development.
The edible portions of any animal used for food including domestic mammals (the major ones being cattle, swine, and sheep) along with poultry, fish, shellfish, and game.
The external elements and conditions which surround, influence, and affect the life and development of an organism or population.
A plant genus of the family Phrymaceae. Members contain 6-geranylflavanones and mimulone.
Expanded structures, usually green, of vascular plants, characteristically consisting of a bladelike expansion attached to a stem, and functioning as the principal organ of photosynthesis and transpiration. (American Heritage Dictionary, 2d ed)
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
Deoxyribonucleic acid that makes up the genetic material of plants.
Substituted thioglucosides. They are found in rapeseed (Brassica campestris) products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in animals and humans.
A species of SWINE, in the family Suidae, comprising a number of subspecies including the domestic pig Sus scrofa domestica.
The transmission of traits encoded in GENES from parent to offspring.
A plant species cultivated for the seed used as animal feed and as a source of canola cooking oil.
A plant genus of the family SOLANACEAE. Members contain SOLANACEOUS ALKALOIDS. Some species in this genus are called deadly nightshade which is also a common name for ATROPA BELLADONNA.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
A family composed of spouses and their children.
Inbreed BN (Brown Norway) rats are a strain of laboratory rats that are specifically bred for research purposes, characterized by their uniform genetic makeup and susceptibility to various diseases, which makes them ideal models for studying human physiology and pathophysiology.
The presence of two or more genetic loci on the same chromosome. Extensions of this original definition refer to the similarity in content and organization between chromosomes, of different species for example.
Inbred rats derived from Sprague-Dawley rats and used for the study of salt-dependent hypertension. Salt-sensitive and salt-resistant strains have been selectively bred to show the opposite genetically determined blood pressure responses to excess sodium chloride ingestion.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The chromosomal constitution of cells, in which each type of CHROMOSOME is represented once. Symbol: N.
A plant species of the family SOLANACEAE, native of South America, widely cultivated for their edible, fleshy, usually red fruit.
A hereditary disease of the hip joints in dogs. Signs of the disease may be evident any time after 4 weeks of age.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Application of statistical procedures to analyze specific observed or assumed facts from a particular study.
A method for ordering genetic loci along CHROMOSOMES. The method involves fusing irradiated donor cells with host cells from another species. Following cell fusion, fragments of DNA from the irradiated cells become integrated into the chromosomes of the host cells. Molecular probing of DNA obtained from the fused cells is used to determine if two or more genetic loci are located within the same fragment of donor cell DNA.
A stochastic process such that the conditional probability distribution for a state at any future instant, given the present state, is unaffected by any additional knowledge of the past history of the system.
A plant genus of the family POACEAE. The grain is used for FOOD and for ANIMAL FEED. This should not be confused with KAFFIR LIME or with KEFIR milk product.
Geographic variety, population, or race, within a species, that is genetically adapted to a particular habitat. An ecotype typically exhibits phenotypic differences but is capable of interbreeding with other ecotypes.
Databases devoted to knowledge about specific genes and gene products.
Chromosomal, biochemical, intracellular, and other methods used in the study of genetics.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in plants.
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
Genes that influence the PHENOTYPE both in the homozygous and the heterozygous state.
Prolonged dry periods in natural climate cycle. They are slow-onset phenomena caused by rainfall deficit combined with other predisposing factors.
Sequential operating programs and data which instruct the functioning of a digital computer.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Inbred C3H mice are a strain of laboratory mice that have been selectively bred to maintain a high degree of genetic uniformity and share specific genetic characteristics, including susceptibility to certain diseases, which makes them valuable for biomedical research purposes.
An individual having different alleles at one or more loci regarding a specific character.
A genus of trees of the Myrtaceae family, native to Australia, that yields gums, oils, and resins which are used as flavoring agents, astringents, and aromatics.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
An individual in which both alleles at a given locus are identical.
Partial cDNA (DNA, COMPLEMENTARY) sequences that are unique to the cDNAs from which they were derived.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.
A principle of estimation in which the estimates of a set of parameters in a statistical model are those quantities minimizing the sum of squared differences between the observed values of a dependent variable and the values predicted by the model.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
The total process by which organisms produce offspring. (Stedman, 25th ed)
The physical measurements of a body.
An annual legume. The SEEDS of this plant are edible and used to produce a variety of SOY FOODS.
Variation occurring within a species in the presence or length of DNA fragment generated by a specific endonuclease at a specific site in the genome. Such variations are generated by mutations that create or abolish recognition sites for these enzymes or change the length of the fragment.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A phylum of fungi which have cross-walls or septa in the mycelium. The perfect state is characterized by the formation of a saclike cell (ascus) containing ascospores. Most pathogenic fungi with a known perfect state belong to this phylum.
The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.
Proteins found in plants (flowers, herbs, shrubs, trees, etc.). The concept does not include proteins found in vegetables for which VEGETABLE PROTEINS is available.
The experimental study of the relationship between the genotype of an organism and its behavior. The scope includes the effects of genes on simple sensory processes to complex organization of the nervous system.
A plant genus of the family POACEAE. The seed is one of the millets used in EDIBLE GRAIN. It contains vitexin. The common name of buffelgrass is also used for CENCHRUS.
The variable phenotypic expression of a GENE depending on whether it is of paternal or maternal origin, which is a function of the DNA METHYLATION pattern. Imprinted regions are observed to be more methylated and less transcriptionally active. (Segen, Dictionary of Modern Medicine, 1992)
A genus herbs of the Asteraceae family. The SEEDS yield oil and are used as food and animal feed; the roots of Helianthus tuberosus (Jerusalem artichoke) are edible.
Very long DNA molecules and associated proteins, HISTONES, and non-histone chromosomal proteins (CHROMOSOMAL PROTEINS, NON-HISTONE). Normally 46 chromosomes, including two sex chromosomes are found in the nucleus of human cells. They carry the hereditary information of the individual.
A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke.
Those characteristics that distinguish one SEX from the other. The primary sex characteristics are the OVARIES and TESTES and their related hormones. Secondary sex characteristics are those which are masculine or feminine but not directly related to reproduction.
Any of a group of bone disorders involving one or more ossification centers (EPIPHYSES). It is characterized by degeneration or NECROSIS followed by revascularization and reossification. Osteochondrosis often occurs in children causing varying degrees of discomfort or pain. There are many eponymic types for specific affected areas, such as tarsal navicular (Kohler disease) and tibial tuberosity (Osgood-Schlatter disease).
Methods used to determine individuals' specific ALLELES or SNPS (single nucleotide polymorphisms).
A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR).
The fleshy or dry ripened ovary of a plant, enclosing the seed or seeds.
The measurement of an organ in volume, mass, or heaviness.
The white liquid secreted by the mammary glands. It contains proteins, sugar, lipids, vitamins, and minerals.
The female sex chromosome, being the differential sex chromosome carried by half the male gametes and all female gametes in human and other male-heterogametic species.
Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.
The complete summaries of the frequencies of the values or categories of a measurement made on a group of items, a population, or other collection of data. The distribution tells either how many or what proportion of the group was found to have each value (or each range of values) out of all the possible values that the quantitative measure can have.
A species of fruit fly much used in genetics because of the large size of its chromosomes.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Persons or animals having at least one parent in common. (American College Dictionary, 3d ed)
The detection of RESTRICTION FRAGMENT LENGTH POLYMORPHISMS by selective PCR amplification of restriction fragments derived from genomic DNA followed by electrophoretic analysis of the amplified restriction fragments.
The initial stages of the growth of SEEDS into a SEEDLINGS. The embryonic shoot (plumule) and embryonic PLANT ROOTS (radicle) emerge and grow upwards and downwards respectively. Food reserves for germination come from endosperm tissue within the seed and/or from the seed leaves (COTYLEDON). (Concise Dictionary of Biology, 1990)
The capacity of a normal organism to remain unaffected by microorganisms and their toxins. It results from the presence of naturally occurring ANTI-INFECTIVE AGENTS, constitutional factors such as BODY TEMPERATURE and immediate acting immune cells such as NATURAL KILLER CELLS.
The percent frequency with which a dominant or homozygous recessive gene or gene combination manifests itself in the phenotype of the carriers. (From Glossary of Genetics, 5th ed)
The combined effects of genotypes and environmental factors together on phenotypic characteristics.
Coloration or discoloration of a part by a pigment.
A plant species of the genus SOLANUM, family SOLANACEAE. The fruit is a large, egg-shaped berry, varying in color from dark purple to red, yellowish, or white. The leaves are large and ovate. The flowers are pendant, violet, and two inches across.
One of the two pairs of human chromosomes in the group B class (CHROMOSOMES, HUMAN, 4-5).
The total number of individuals inhabiting a particular region or area.
A plant species of the genus PINUS which is the subject of genetic study.
Very young plant after GERMINATION of SEEDS.
DNA constructs that are composed of, at least, a REPLICATION ORIGIN, for successful replication, propagation to and maintenance as an extra chromosome in bacteria. In addition, they can carry large amounts (about 200 kilobases) of other sequence for a variety of bioengineering purposes.
PLANTS, or their progeny, whose GENOME has been altered by GENETIC ENGINEERING.
New immature growth of a plant including stem, leaves, tips of branches, and SEEDLINGS.
A specific pair GROUP C CHROMSOMES of the human chromosome classification.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Gradual increase in the number, the size, and the complexity of cells of an individual. Growth generally results in increase in ORGAN WEIGHT; BODY WEIGHT; and BODY HEIGHT.
A test used to determine whether or not complementation (compensation in the form of dominance) will occur in a cell with a given mutant phenotype when another mutant genome, encoding the same mutant phenotype, is introduced into that cell.
The non-genetic biological changes of an organism in response to challenges in its ENVIRONMENT.
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
The relationships of groups of organisms as reflected by their genetic makeup.
Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations.
The use of statistical and mathematical methods to analyze biological observations and phenomena.
The functional hereditary units of INSECTS.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Inbred strain A mice are genetically identical descendants of a single founder mouse, produced by many generations of brother-sister matings, primarily used in biomedical research for their genetic uniformity and experimental reproducibility.
Parts of plants that usually grow vertically upwards towards the light and support the leaves, buds, and reproductive structures. (From Concise Dictionary of Biology, 1990)
Mathematical procedure that transforms a number of possibly correlated variables into a smaller number of uncorrelated variables called principal components.
A specific pair of GROUP B CHROMOSOMES of the human chromosome classification.
The inherent or induced capacity of plants to withstand or ward off biological attack by pathogens.
A technique for growing plants in culture solutions rather than in soil. The roots are immersed in an aerated solution containing the correct proportions of essential mineral salts. (From Concise Dictionary of Biology, 1990)
Seeds from grasses (POACEAE) which are important in the diet.

Quantitative trait loci for component physiological traits determining salt tolerance in rice. (1/4986)

Rice (Oryza sativa) is sensitive to salinity, which affects one-fifth of irrigated land worldwide. Reducing sodium and chloride uptake into rice while maintaining potassium uptake are characteristics that would aid growth under saline conditions. We describe genetic determinants of the net quantity of ions transported to the shoot, clearly distinguishing between quantitative trait loci (QTL) for the quantity of ions in a shoot and for those that affect the concentration of an ion in the shoot. The latter coincide with QTL for vegetative growth (vigor) and their interpretation is therefore ambiguous. We distinguished those QTL that are independent of vigor and thus directly indicate quantitative variation in the underlying mechanisms of ion uptake. These QTL independently govern sodium uptake, potassium uptake, and sodium:potassium selectivity. The QTL for sodium and potassium uptake are on different linkage groups (chromosomes). This is consistent with the independent inheritance of sodium and potassium uptake in the mapping population and with the mechanistically different uptake pathways for sodium and potassium in rice under saline conditions (apoplastic leakage and membrane transport, respectively). We report the chromosomal location of ion transport and selectivity traits that are compatible with agronomic needs and we indicate markers to assist selection in a breeding program. Based upon knowledge of the underlying mechanisms of ion uptake in rice, we argue that QTL for sodium transport are likely to act through the control of root development, whereas QTL for potassium uptake are likely to act through the structure or regulation of membrane-sited transport components.  (+info)

Complex trait analysis of the mouse striatum: independent QTLs modulate volume and neuron number. (2/4986)

BACKGROUND: The striatum plays a pivotal role in modulating motor activity and higher cognitive function. We analyzed variation in striatal volume and neuron number in mice and initiated a complex trait analysis to discover polymorphic genes that modulate the structure of the basal ganglia. RESULTS: Brain weight, brain and striatal volume, neuron-packing density and number were estimated bilaterally using unbiased stereological procedures in five inbred strains (A/J, C57BL/6J, DBA/2J, BALB/cJ, and BXD5) and an F2 intercross between A/J and BXD5. Striatal volume ranged from 20 to 37 mm3. Neuron-packing density ranged from approximately 50,000 to 100,000 neurons/mm3, and the striatal neuron population ranged from 1.4 to 2.5 million. Inbred animals with larger brains had larger striata but lower neuron-packing density resulting in a narrow range of average neuron populations. In contrast, there was a strong positive correlation between volume and neuron number among intercross progeny. We mapped two quantitative trait loci (QTLs) with selective effects on striatal architecture. Bsc10a maps to the central region of Chr 10 (LRS of 17.5 near D10Mit186) and has intense effects on striatal volume and moderate effects on brain volume. Stnn19a maps to distal Chr 19 (LRS of 15 at D19Mit123) and is associated with differences of up to 400,000 neurons among animals. CONCLUSION: We have discovered remarkable numerical and volumetric variation in the mouse striatum, and we have been able to map two QTLs that modulate independent anatomic parameters.  (+info)

Genotyping in the MHC locus: potential for defining predictive markers in sarcoidosis. (3/4986)

In sarcoidosis, host genetic factors are discussed as contributing to disease susceptibility and course. Since tumor necrosis factor (TNF)-alpha is a central mediator of granuloma formation and since elevated TNF-alpha levels are found during active phases of sarcoidosis, genetic polymorphisms correlating with influences on TNF-alpha levels are of special interest. The complete sequencing of the MHC region and the increase in the number of identified gene polymorphisms in this locus associated with TNF-alpha production offer the opportunity of detecting new genes associated with sarcoidosis and perhaps of defining disease-associated haplotypes that bear the potential of serving as predictive markers for this disease.  (+info)

Analyses of differential gene expression in genetic hypertensive rats by microarray. (4/4986)

We identified genes that were differentially expressed between spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) using cDNA microarray analysis, and analyzed the correlation between these genes and hypertension. Twenty four genes were found to be up-regulated and 20 were down-regulated in SHR. We selected 11 genes (6 up-regulated genes: SAH, Hsp70, MCT1, RBP, IDI1, Prion; and 5 down-regulated genes: Thrombin, Dyn, SOD3, Ela1, Gst Y(b)) and subjected them to an F2 cosegregation analysis. One hundred five F2 rats were obtained from the same strains used for microarray analysis, and blood pressure was measured directly with a catheter implanted in the femoral artery. The genotypes of monocarboxylate transporter 1 and glutathione S-transferase Y(b) subunit significantly affected diastolic blood pressure in F2 rats, and these two genes are located near each other on chromosome 2. However, quantitative trait loci (QTL) analysis in this region revealed that the QTL for diastolic blood pressure were from these two genes. Antihypertensive treatment with either enalapril or hydralazine only affected the expression level of Hsp70, which was up-regulated by hydralazine, probably through compensatory sympathetic activation. We were unable to associate the other 10 genes with hypertension in SHR. Based on these results, the identification of differentially expressed genes may not be an efficient method for selecting candidate genes for hypertension in the SHR-WKY system.  (+info)

Identification of genetic loci controlling bacterial clearance in experimental Salmonella enteritidis infection: an unexpected role of Nramp1 (Slc11a1) in the persistence of infection in mice. (5/4986)

The Gram-negative bacteria, Salmonella, cause a broad spectrum of clinical diseases in both animals and humans ranging from asymptomatic carriage to life-threatening sepsis. We have developed a model to study the contribution of genetic factors to the susceptibility of 129sv and C57BL/6J inbred mice to Salmonella enteritidis during the late phase of infection. C57BL/6J mice were able to eliminate completely sublethal inoculums of S. enteritidis from their reticuloendothelial system, whereas 129sv mice could not even after 60 days post inoculation. A genome scan performed on 302 (C57BL/6J x 129sv) F2 progeny identified three dominant loci (designated Ses1 to Ses3) that are associated with disease susceptibility in 129sv mice. Two highly significant linkages were identified on chromosomes 1 (Ses1) and 7 (Ses2) with respective LOD scores of 9.9 (P = 1.4 x 10(-11)) at D1Mcg5 and 4.0 (P = 1.9 x 10(-5)) at D7Mit62. One highly suggestive QTL was located on chromosomes15 (Ses3) with a LOD score 3.4 (P = 1.2 x 10(-4)). The estimated effects of Ses1, Ses2 and Ses3 on the bacterial clearance were greater in females. Using a model of three loci, with interaction between Ses1 and Ses2 and sex as a covariate, the three QTLs explained 32% of the phenotypic variance. The candidacy of Nramp1 as the gene for Ses1 was evaluated using mice carrying a null allele at Nramp1 (129sv-Nramp1(tm1Mcg)). These mice have a significantly lower spleen bacterial load compared to the wild-type 129sv mice, strongly suggesting the involvement of Nramp1 in controlling S. enteritidis clearance during the late phase of infection.  (+info)

Plant defense genes associated with quantitative resistance to potato late blight in Solanum phureja x dihaploid S. tuberosum hybrids. (6/4986)

Markers corresponding to 27 plant defense genes were tested for linkage disequilibrium with quantitative resistance to late blight in a diploid potato population that had been used for mapping quantitative trait loci (QTLs) for late blight resistance. Markers were detected by using (i) hybridization probes for plant defense genes, (ii) primer pairs amplifying conserved domains of resistance (R) genes, (iii) primers for defense genes and genes encoding transcriptional regulatory factors, and (iv) primers allowing amplification of sequences flanking plant defense genes by the ligation-mediated polymerase chain reaction. Markers were initially screened by using the most resistant and susceptible individuals of the population, and those markers showing different allele frequencies between the two groups were mapped. Among the 308 segregating bands detected, 24 loci (8%) corresponding to six defense gene families were associated with resistance at chi2 > or = 13, the threshold established using the permutation test at P = 0.05. Loci corresponding to genes related to the phenylpropanoid pathway (phenylalanine ammonium lyase [PAL], chalcone isomerase [CHI], and chalcone synthase [CHS]), loci related to WRKY regulatory genes, and other -defense genes (osmotin and a Phytophthora infestans-induced cytochrome P450) were significantly associated with quantitative disease resistance. A subset of markers was tested on the mapping population of 94 individuals. Ten defense-related markers were clustered at a QTL on chromosome III, and three defense-related markers were located at a broad QTL on chromosome XII. The association of candidate genes with QTLs is a step toward understanding the molecular basis of quantitative resistance to an important plant disease.  (+info)

The genetic basis of the interspecific differences in wing size in Nasonia (Hymenoptera; Pteromalidae): major quantitative trait loci and epistasis. (7/4986)

There is a 2.5-fold difference in male wing size between two haplodiploid insect species, Nasonia vitripennis and N. giraulti. The haploidy of males facilitated a full genomic screen for quantitative trait loci (QTL) affecting wing size and the detection of epistatic interactions. A QTL analysis of the interspecific wing-size difference revealed QTL with major effects and epistatic interactions among loci affecting the trait. We analyzed 178 hybrid males and initially found two major QTL for wing length, one for wing width, three for a normalized wing-size variable, and five for wing seta density. One QTL for wing width explains 38.1% of the phenotypic variance, and the same QTL explains 22% of the phenotypic variance in normalized wing size. This corresponds to a region previously introgressed from N. giraulti into N. vitripennis that accounts for 44% of the normalized wing-size difference between the species. Significant epistatic interactions were also found that affect wing size and density of setae on the wing. Screening for pairwise epistatic interactions between loci on different linkage groups revealed four additional loci for wing length and four loci for normalized wing size that were not detected in the original QTL analysis. We propose that the evolution of smaller wings in N. vitripennis males is primarily the result of major mutations at few genomic regions and involves epistatic interactions among some loci.  (+info)

Nonequivalent Loci and the distribution of mutant effects. (8/4986)

It has been observed repeatedly that the distribution of new mutations of a quantitative trait has a kurtosis (a statistical measure of the distribution's shape) that is systematically larger than that of a normal distribution. Here we suggest that rather than being a property of individual loci that control the trait, the enhanced kurtosis is highly likely to be an emergent property that arises directly from the loci being mutationally nonequivalent. We present a method of incorporating nonequivalent loci into quantitative genetic modeling and give an approximate relation between the kurtosis of the mutant distribution and the degree of mutational nonequivalence of loci. We go on to ask whether incorporating the experimentally observed kurtosis through nonequivalent loci, rather than at locus level, affects any biologically important conclusions of quantitative genetic modeling. Concentrating on the maintenance of quantitative genetic variation by mutation-selection balance, we conclude that typically nonequivalent loci yield a genetic variance that is of order 10% smaller than that obtained from the previous approaches. For large populations, when the kurtosis is large, the genetic variance may be <50% of the result of equivalent loci, with Gaussian distributions of mutant effects.  (+info)

Quantitative Trait Loci (QTL) are regions of the genome that are associated with variation in quantitative traits, which are traits that vary continuously in a population and are influenced by multiple genes and environmental factors. QTLs can help to explain how genetic variations contribute to differences in complex traits such as height, blood pressure, or disease susceptibility.

Quantitative trait loci are identified through statistical analysis of genetic markers and trait values in experimental crosses between genetically distinct individuals, such as strains of mice or plants. The location of a QTL is inferred based on the pattern of linkage disequilibrium between genetic markers and the trait of interest. Once a QTL has been identified, further analysis can be conducted to identify the specific gene or genes responsible for the variation in the trait.

It's important to note that QTLs are not themselves genes, but rather genomic regions that contain one or more genes that contribute to the variation in a quantitative trait. Additionally, because QTLs are identified through statistical analysis, they represent probabilistic estimates of the location of genetic factors influencing a trait and may encompass large genomic regions containing multiple genes. Therefore, additional research is often required to fine-map and identify the specific genes responsible for the variation in the trait.

A quantitative trait is a phenotypic characteristic that can be measured and displays continuous variation, meaning it can take on any value within a range. Examples include height, blood pressure, or biochemical measurements like cholesterol levels. These traits are usually influenced by the combined effects of multiple genes (polygenic inheritance) as well as environmental factors.

Heritability, in the context of genetics, refers to the proportion of variation in a trait that can be attributed to genetic differences among individuals in a population. It is estimated using statistical methods and ranges from 0 to 1, with higher values indicating a greater contribution of genetics to the observed phenotypic variance.

Therefore, a heritable quantitative trait would be a phenotype that shows continuous variation, influenced by multiple genes and environmental factors, and for which a significant portion of the observed variation can be attributed to genetic differences among individuals in a population.

Chromosome mapping, also known as physical mapping, is the process of determining the location and order of specific genes or genetic markers on a chromosome. This is typically done by using various laboratory techniques to identify landmarks along the chromosome, such as restriction enzyme cutting sites or patterns of DNA sequence repeats. The resulting map provides important information about the organization and structure of the genome, and can be used for a variety of purposes, including identifying the location of genes associated with genetic diseases, studying evolutionary relationships between organisms, and developing genetic markers for use in breeding or forensic applications.

"Genetic crosses" refer to the breeding of individuals with different genetic characteristics to produce offspring with specific combinations of traits. This process is commonly used in genetics research to study the inheritance patterns and function of specific genes.

There are several types of genetic crosses, including:

1. Monohybrid cross: A cross between two individuals that differ in the expression of a single gene or trait.
2. Dihybrid cross: A cross between two individuals that differ in the expression of two genes or traits.
3. Backcross: A cross between an individual from a hybrid population and one of its parental lines.
4. Testcross: A cross between an individual with unknown genotype and a homozygous recessive individual.
5. Reciprocal cross: A cross in which the male and female parents are reversed to determine if there is any effect of sex on the expression of the trait.

These genetic crosses help researchers to understand the mode of inheritance, linkage, recombination, and other genetic phenomena.

Genetic markers are specific segments of DNA that are used in genetic mapping and genotyping to identify specific genetic locations, diseases, or traits. They can be composed of short tandem repeats (STRs), single nucleotide polymorphisms (SNPs), restriction fragment length polymorphisms (RFLPs), or variable number tandem repeats (VNTRs). These markers are useful in various fields such as genetic research, medical diagnostics, forensic science, and breeding programs. They can help to track inheritance patterns, identify genetic predispositions to diseases, and solve crimes by linking biological evidence to suspects or victims.

Genetic linkage is the phenomenon where two or more genetic loci (locations on a chromosome) tend to be inherited together because they are close to each other on the same chromosome. This occurs during the process of sexual reproduction, where homologous chromosomes pair up and exchange genetic material through a process called crossing over.

The closer two loci are to each other on a chromosome, the lower the probability that they will be separated by a crossover event. As a result, they are more likely to be inherited together and are said to be linked. The degree of linkage between two loci can be measured by their recombination frequency, which is the percentage of meiotic events in which a crossover occurs between them.

Linkage analysis is an important tool in genetic research, as it allows researchers to identify and map genes that are associated with specific traits or diseases. By analyzing patterns of linkage between markers (identifiable DNA sequences) and phenotypes (observable traits), researchers can infer the location of genes that contribute to those traits or diseases on chromosomes.

Mammalian chromosomes are thread-like structures that exist in the nucleus of mammalian cells, consisting of DNA, hist proteins, and RNA. They carry genetic information that is essential for the development and function of all living organisms. In mammals, each cell contains 23 pairs of chromosomes, for a total of 46 chromosomes, with one set inherited from the mother and the other from the father.

The chromosomes are typically visualized during cell division, where they condense and become visible under a microscope. Each chromosome is composed of two identical arms, separated by a constriction called the centromere. The short arm of the chromosome is labeled as "p," while the long arm is labeled as "q."

Mammalian chromosomes play a critical role in the transmission of genetic information from one generation to the next and are essential for maintaining the stability and integrity of the genome. Abnormalities in the number or structure of mammalian chromosomes can lead to various genetic disorders, including Down syndrome, Turner syndrome, and Klinefelter syndrome.

A phenotype is the physical or biochemical expression of an organism's genes, or the observable traits and characteristics resulting from the interaction of its genetic constitution (genotype) with environmental factors. These characteristics can include appearance, development, behavior, and resistance to disease, among others. Phenotypes can vary widely, even among individuals with identical genotypes, due to differences in environmental influences, gene expression, and genetic interactions.

Genetic models are theoretical frameworks used in genetics to describe and explain the inheritance patterns and genetic architecture of traits, diseases, or phenomena. These models are based on mathematical equations and statistical methods that incorporate information about gene frequencies, modes of inheritance, and the effects of environmental factors. They can be used to predict the probability of certain genetic outcomes, to understand the genetic basis of complex traits, and to inform medical management and treatment decisions.

There are several types of genetic models, including:

1. Mendelian models: These models describe the inheritance patterns of simple genetic traits that follow Mendel's laws of segregation and independent assortment. Examples include autosomal dominant, autosomal recessive, and X-linked inheritance.
2. Complex trait models: These models describe the inheritance patterns of complex traits that are influenced by multiple genes and environmental factors. Examples include heart disease, diabetes, and cancer.
3. Population genetics models: These models describe the distribution and frequency of genetic variants within populations over time. They can be used to study evolutionary processes, such as natural selection and genetic drift.
4. Quantitative genetics models: These models describe the relationship between genetic variation and phenotypic variation in continuous traits, such as height or IQ. They can be used to estimate heritability and to identify quantitative trait loci (QTLs) that contribute to trait variation.
5. Statistical genetics models: These models use statistical methods to analyze genetic data and infer the presence of genetic associations or linkage. They can be used to identify genetic risk factors for diseases or traits.

Overall, genetic models are essential tools in genetics research and medical genetics, as they allow researchers to make predictions about genetic outcomes, test hypotheses about the genetic basis of traits and diseases, and develop strategies for prevention, diagnosis, and treatment.

Epistasis is a phenomenon in genetics where the effect of one gene (the "epistatic" gene) is modified by one or more other genes (the "modifier" genes). This interaction can result in different phenotypic expressions than what would be expected based on the individual effects of each gene.

In other words, epistasis occurs when the expression of one gene is influenced by the presence or absence of another gene. The gene that is being masked or modified is referred to as the hypostatic gene, while the gene doing the masking or modifying is called the epistatic gene.

Epistasis can take many forms and can be involved in complex genetic traits and diseases. It can also make it more difficult to map genes associated with certain traits or conditions because the phenotypic expression may not follow simple Mendelian inheritance patterns.

There are several types of epistasis, including recessive-recessive, dominant-recessive, and dominant-dominant epistasis. In recessive-recessive epistasis, for example, the presence of two copies of the epistatic gene prevents the expression of the hypostatic gene, even if the individual has two copies of the hypostatic gene.

Understanding epistasis is important in genetics because it can help researchers better understand the genetic basis of complex traits and diseases, as well as improve breeding programs for plants and animals.

Congenic animals are genetically identical organisms, except for a specific genetic locus or region that has been intentionally altered. In the context of animal research, congenic animals are created through selective breeding to transfer a particular gene or genes from one strain to another while keeping the rest of the genetic background as similar as possible.

The process involves repeatedly backcrossing the offspring of the initial cross between two strains to one of the parental strains for several generations, followed by brother-sister mating to establish a congenic strain. The resulting congenic animals share more than 99% of their genetic material with the recipient strain but carry the donor strain's gene(s) at the specific locus of interest.

Congenic animal models are essential tools in biomedical research, as they allow researchers to study the effects of a particular gene or genetic variant while minimizing the influence of other genetic factors. These models help isolate the contribution of a single gene to a phenotype, disease susceptibility, or drug response, facilitating a better understanding of complex biological processes and potential therapeutic interventions.

Genotype, in genetics, refers to the complete heritable genetic makeup of an individual organism, including all of its genes. It is the set of instructions contained in an organism's DNA for the development and function of that organism. The genotype is the basis for an individual's inherited traits, and it can be contrasted with an individual's phenotype, which refers to the observable physical or biochemical characteristics of an organism that result from the expression of its genes in combination with environmental influences.

It is important to note that an individual's genotype is not necessarily identical to their genetic sequence. Some genes have multiple forms called alleles, and an individual may inherit different alleles for a given gene from each parent. The combination of alleles that an individual inherits for a particular gene is known as their genotype for that gene.

Understanding an individual's genotype can provide important information about their susceptibility to certain diseases, their response to drugs and other treatments, and their risk of passing on inherited genetic disorders to their offspring.

Inbreeding, in a medical context, refers to the practice of mating closely related individuals within a given family or breeding population. This leads to an increased proportion of homozygous genes, meaning that the same alleles (versions of a gene) are inherited from both parents. As a result, recessive traits and disorders become more likely to be expressed because the necessary dominant allele may be absent.

In human medicine, consanguinity is the term often used instead of inbreeding, and it refers to relationships between individuals who share a common ancestor. Consanguinity increases the risk of certain genetic disorders due to the increased likelihood of sharing harmful recessive genes. The closer the relationship, the higher the risk.

In animal breeding, inbreeding can lead to reduced fertility, lower birth weights, higher infant mortality, and a decreased lifespan. It is crucial to maintain genetic diversity within populations to ensure their overall health and vigor.

A LOD (Logarithm of Odds) score is not a medical term per se, but rather a statistical concept that is used in genetic research and linkage analysis to determine the likelihood of a gene or genetic marker being linked to a particular disease or trait. The LOD score compares the odds of observing the pattern of inheritance of a genetic marker in a family if the marker is linked to the disease, versus the odds if the marker is not linked. A LOD score of 3 or higher is generally considered evidence for linkage, while a score of -2 or lower is considered evidence against linkage.

Chromosomes in plants are thread-like structures that contain genetic material, DNA, and proteins. They are present in the nucleus of every cell and are inherited from the parent plants during sexual reproduction. Chromosomes come in pairs, with each pair consisting of one chromosome from each parent.

In plants, like in other organisms, chromosomes play a crucial role in inheritance, development, and reproduction. They carry genetic information that determines various traits and characteristics of the plant, such as its physical appearance, growth patterns, and resistance to diseases.

Plant chromosomes are typically much larger than those found in animals, making them easier to study under a microscope. The number of chromosomes varies among different plant species, ranging from as few as 2 in some ferns to over 1000 in certain varieties of wheat.

During cell division, the chromosomes replicate and then separate into two identical sets, ensuring that each new cell receives a complete set of genetic information. This process is critical for the growth and development of the plant, as well as for the production of viable seeds and offspring.

Genetic variation refers to the differences in DNA sequences among individuals and populations. These variations can result from mutations, genetic recombination, or gene flow between populations. Genetic variation is essential for evolution by providing the raw material upon which natural selection acts. It can occur within a single gene, between different genes, or at larger scales, such as differences in the number of chromosomes or entire sets of chromosomes. The study of genetic variation is crucial in understanding the genetic basis of diseases and traits, as well as the evolutionary history and relationships among species.

Microsatellite repeats, also known as short tandem repeats (STRs), are repetitive DNA sequences made up of units of 1-6 base pairs that are repeated in a head-to-tail manner. These repeats are spread throughout the human genome and are highly polymorphic, meaning they can have different numbers of repeat units in different individuals.

Microsatellites are useful as genetic markers because of their high degree of variability. They are commonly used in forensic science to identify individuals, in genealogy to trace ancestry, and in medical research to study genetic diseases and disorders. Mutations in microsatellite repeats have been associated with various neurological conditions, including Huntington's disease and fragile X syndrome.

In medical terms, "breeding" is not a term that is commonly used. It is more frequently used in the context of animal husbandry to refer to the process of mating animals in order to produce offspring with specific desired traits or characteristics. In human medicine, the term is not typically applied to people and instead, related concepts such as reproduction, conception, or pregnancy are used.

An allele is a variant form of a gene that is located at a specific position on a specific chromosome. Alleles are alternative forms of the same gene that arise by mutation and are found at the same locus or position on homologous chromosomes.

Each person typically inherits two copies of each gene, one from each parent. If the two alleles are identical, a person is said to be homozygous for that trait. If the alleles are different, the person is heterozygous.

For example, the ABO blood group system has three alleles, A, B, and O, which determine a person's blood type. If a person inherits two A alleles, they will have type A blood; if they inherit one A and one B allele, they will have type AB blood; if they inherit two B alleles, they will have type B blood; and if they inherit two O alleles, they will have type O blood.

Alleles can also influence traits such as eye color, hair color, height, and other physical characteristics. Some alleles are dominant, meaning that only one copy of the allele is needed to express the trait, while others are recessive, meaning that two copies of the allele are needed to express the trait.

Single Nucleotide Polymorphism (SNP) is a type of genetic variation that occurs when a single nucleotide (A, T, C, or G) in the DNA sequence is altered. This alteration must occur in at least 1% of the population to be considered a SNP. These variations can help explain why some people are more susceptible to certain diseases than others and can also influence how an individual responds to certain medications. SNPs can serve as biological markers, helping scientists locate genes that are associated with disease. They can also provide information about an individual's ancestry and ethnic background.

A genome is the complete set of genetic material (DNA, or in some viruses, RNA) present in a single cell of an organism. It includes all of the genes, both coding and noncoding, as well as other regulatory elements that together determine the unique characteristics of that organism. The human genome, for example, contains approximately 3 billion base pairs and about 20,000-25,000 protein-coding genes.

The term "genome" was first coined by Hans Winkler in 1920, derived from the word "gene" and the suffix "-ome," which refers to a complete set of something. The study of genomes is known as genomics.

Understanding the genome can provide valuable insights into the genetic basis of diseases, evolution, and other biological processes. With advancements in sequencing technologies, it has become possible to determine the entire genomic sequence of many organisms, including humans, and use this information for various applications such as personalized medicine, gene therapy, and biotechnology.

Linkage disequilibrium (LD) is a term used in genetics that refers to the non-random association of alleles at different loci (genetic locations) on a chromosome. This means that certain combinations of genetic variants, or alleles, at different loci occur more frequently together in a population than would be expected by chance.

Linkage disequilibrium can arise due to various factors such as genetic drift, selection, mutation, and population structure. It is often used in the context of genetic mapping studies to identify regions of the genome that are associated with particular traits or diseases. High levels of LD in a region of the genome suggest that the loci within that region are in linkage, meaning they tend to be inherited together.

The degree of LD between two loci can be measured using various statistical methods, such as D' and r-squared. These measures provide information about the strength and direction of the association between alleles at different loci, which can help researchers identify causal genetic variants underlying complex traits or diseases.

Multifactorial inheritance is a type of genetic inheritance that involves the interaction of multiple genes (two or more) along with environmental factors in the development of a particular trait, disorder, or disease. Each gene can slightly increase or decrease the risk of developing the condition, and the combined effects of these genes, along with environmental influences, determine the ultimate outcome.

Examples of multifactorial inheritance include height, skin color, and many common diseases such as heart disease, diabetes, and mental disorders like schizophrenia and autism. These conditions tend to run in families but do not follow simple Mendelian patterns of inheritance (dominant or recessive). Instead, they show complex inheritance patterns that are influenced by multiple genetic and environmental factors.

It is important to note that having a family history of a multifactorial disorder does not guarantee that an individual will develop the condition. However, it does increase the likelihood, and the risk may be further modified by lifestyle choices, environmental exposures, and other health factors.

A Genome-Wide Association Study (GWAS) is an analytical approach used in genetic research to identify associations between genetic variants, typically Single Nucleotide Polymorphisms (SNPs), and specific traits or diseases across the entire genome. This method involves scanning the genomes of many individuals, usually thousands, to find genetic markers that occur more frequently in people with a particular disease or trait than in those without it.

The goal of a GWAS is to identify genetic loci (positions on chromosomes) associated with a trait or disease, which can help researchers understand the underlying genetic architecture and biological mechanisms contributing to the condition. It's important to note that while GWAS can identify associations between genetic variants and traits/diseases, these studies do not necessarily prove causation. Further functional validation studies are often required to confirm the role of identified genetic variants in the development or progression of a trait or disease.

Congenic mice are strains that have been developed through a specific breeding process to be genetically identical, except for a small region of interest (ROI) that has been introgressed from a donor strain. This is achieved by repeatedly backcrossing the donor ROI onto the genetic background of a recipient strain for many generations, followed by intercrossing within the resulting congenic line to ensure homozygosity of the ROI.

The goal of creating congenic mice is to study the effects of a specific gene or genomic region while minimizing the influence of other genetic differences between strains. This allows researchers to investigate the relationship between genotype and phenotype more accurately, which can be particularly useful in biomedical research for understanding complex traits, diseases, and potential therapeutic targets.

A gene in plants, like in other organisms, is a hereditary unit that carries genetic information from one generation to the next. It is a segment of DNA (deoxyribonucleic acid) that contains the instructions for the development and function of an organism. Genes in plants determine various traits such as flower color, plant height, resistance to diseases, and many others. They are responsible for encoding proteins and RNA molecules that play crucial roles in the growth, development, and reproduction of plants. Plant genes can be manipulated through traditional breeding methods or genetic engineering techniques to improve crop yield, enhance disease resistance, and increase nutritional value.

"Oryza sativa" is the scientific name for Asian rice, which is a species of grass and one of the most important food crops in the world. It is a staple food for more than half of the global population, providing a significant source of calories and carbohydrates. There are several varieties of Oryza sativa, including indica and japonica, which differ in their genetic makeup, growth habits, and grain characteristics.

Oryza sativa is an annual plant that grows to a height of 1-2 meters and produces long slender leaves and clusters of flowers at the top of the stem. The grains are enclosed within a tough husk, which must be removed before consumption. Rice is typically grown in flooded fields or paddies, which provide the necessary moisture for germination and growth.

Rice is an important source of nutrition for people around the world, particularly in developing countries where it may be one of the few reliable sources of food. It is rich in carbohydrates, fiber, and various vitamins and minerals, including thiamin, riboflavin, niacin, iron, and magnesium. However, rice can also be a significant source of arsenic, a toxic heavy metal that can accumulate in the grain during growth.

In medical terms, Oryza sativa may be used as a component of nutritional interventions for individuals who are at risk of malnutrition or who have specific dietary needs. It may also be studied in clinical trials to evaluate its potential health benefits or risks.

Physical chromosome mapping, also known as physical mapping or genomic mapping, is the process of determining the location and order of specific genes or DNA sequences along a chromosome based on their physical distance from one another. This is typically done by using various laboratory techniques such as restriction enzyme digestion, fluorescence in situ hybridization (FISH), and chromosome walking to identify the precise location of a particular gene or sequence on a chromosome.

Physical chromosome mapping provides important information about the organization and structure of chromosomes, and it is essential for understanding genetic diseases and disorders. By identifying the specific genes and DNA sequences that are associated with certain conditions, researchers can develop targeted therapies and treatments to improve patient outcomes. Additionally, physical chromosome mapping is an important tool for studying evolution and comparative genomics, as it allows scientists to compare the genetic makeup of different species and identify similarities and differences between them.

Chromosomes are thread-like structures that exist in the nucleus of cells, carrying genetic information in the form of genes. They are composed of DNA and proteins, and are typically present in pairs in the nucleus, with one set inherited from each parent. In humans, there are 23 pairs of chromosomes for a total of 46 chromosomes. Chromosomes come in different shapes and forms, including sex chromosomes (X and Y) that determine the biological sex of an individual. Changes or abnormalities in the number or structure of chromosomes can lead to genetic disorders and diseases.

A genetic locus (plural: loci) is a specific location on a chromosome where a particular gene or DNA sequence is found. It is the precise position where a specific genetic element, such as a gene or marker, is located on a chromsomere. This location is defined in terms of its relationship to other genetic markers and features on the same chromosome. Genetic loci can be used in linkage and association studies to identify the inheritance patterns and potential relationships between genes and various traits or diseases.

"Likelihood functions" is a statistical concept that is used in medical research and other fields to estimate the probability of obtaining a given set of data, given a set of assumptions or parameters. In other words, it is a function that describes how likely it is to observe a particular outcome or result, based on a set of model parameters.

More formally, if we have a statistical model that depends on a set of parameters θ, and we observe some data x, then the likelihood function is defined as:

L(θ | x) = P(x | θ)

This means that the likelihood function describes the probability of observing the data x, given a particular value of the parameter vector θ. By convention, the likelihood function is often expressed as a function of the parameters, rather than the data, so we might instead write:

L(θ) = P(x | θ)

The likelihood function can be used to estimate the values of the model parameters that are most consistent with the observed data. This is typically done by finding the value of θ that maximizes the likelihood function, which is known as the maximum likelihood estimator (MLE). The MLE has many desirable statistical properties, including consistency, efficiency, and asymptotic normality.

In medical research, likelihood functions are often used in the context of Bayesian analysis, where they are combined with prior distributions over the model parameters to obtain posterior distributions that reflect both the observed data and prior knowledge or assumptions about the parameter values. This approach is particularly useful when there is uncertainty or ambiguity about the true value of the parameters, as it allows researchers to incorporate this uncertainty into their analyses in a principled way.

Genetic predisposition to disease refers to an increased susceptibility or vulnerability to develop a particular illness or condition due to inheriting specific genetic variations or mutations from one's parents. These genetic factors can make it more likely for an individual to develop a certain disease, but it does not guarantee that the person will definitely get the disease. Environmental factors, lifestyle choices, and interactions between genes also play crucial roles in determining if a genetically predisposed person will actually develop the disease. It is essential to understand that having a genetic predisposition only implies a higher risk, not an inevitable outcome.

A computer simulation is a process that involves creating a model of a real-world system or phenomenon on a computer and then using that model to run experiments and make predictions about how the system will behave under different conditions. In the medical field, computer simulations are used for a variety of purposes, including:

1. Training and education: Computer simulations can be used to create realistic virtual environments where medical students and professionals can practice their skills and learn new procedures without risk to actual patients. For example, surgeons may use simulation software to practice complex surgical techniques before performing them on real patients.
2. Research and development: Computer simulations can help medical researchers study the behavior of biological systems at a level of detail that would be difficult or impossible to achieve through experimental methods alone. By creating detailed models of cells, tissues, organs, or even entire organisms, researchers can use simulation software to explore how these systems function and how they respond to different stimuli.
3. Drug discovery and development: Computer simulations are an essential tool in modern drug discovery and development. By modeling the behavior of drugs at a molecular level, researchers can predict how they will interact with their targets in the body and identify potential side effects or toxicities. This information can help guide the design of new drugs and reduce the need for expensive and time-consuming clinical trials.
4. Personalized medicine: Computer simulations can be used to create personalized models of individual patients based on their unique genetic, physiological, and environmental characteristics. These models can then be used to predict how a patient will respond to different treatments and identify the most effective therapy for their specific condition.

Overall, computer simulations are a powerful tool in modern medicine, enabling researchers and clinicians to study complex systems and make predictions about how they will behave under a wide range of conditions. By providing insights into the behavior of biological systems at a level of detail that would be difficult or impossible to achieve through experimental methods alone, computer simulations are helping to advance our understanding of human health and disease.

'Zea mays' is the biological name for corn or maize, which is not typically considered a medical term. However, corn or maize can have medical relevance in certain contexts. For example, cornstarch is sometimes used as a diluent for medications and is also a component of some skin products. Corn oil may be found in topical ointments and creams. In addition, some people may have allergic reactions to corn or corn-derived products. But generally speaking, 'Zea mays' itself does not have a specific medical definition.

Genetic hybridization is a biological process that involves the crossing of two individuals from different populations or species, which can lead to the creation of offspring with new combinations of genetic material. This occurs when the gametes (sex cells) from each parent combine during fertilization, resulting in a zygote with a unique genetic makeup.

In genetics, hybridization can also refer to the process of introducing new genetic material into an organism through various means, such as genetic engineering or selective breeding. This type of hybridization is often used in agriculture and biotechnology to create crops or animals with desirable traits, such as increased disease resistance or higher yields.

It's important to note that the term "hybrid" can refer to both crosses between different populations within a single species (intraspecific hybrids) and crosses between different species (interspecific hybrids). The latter is often more challenging, as significant genetic differences between the two parental species can lead to various reproductive barriers, making it difficult for the hybrid offspring to produce viable offspring of their own.

A plant genome refers to the complete set of genetic material or DNA present in the cells of a plant. It contains all the hereditary information necessary for the development and functioning of the plant, including its structural and functional characteristics. The plant genome includes both coding regions that contain instructions for producing proteins and non-coding regions that have various regulatory functions.

The plant genome is composed of several types of DNA molecules, including chromosomes, which are located in the nucleus of the cell. Each chromosome contains one or more genes, which are segments of DNA that code for specific proteins or RNA molecules. Plants typically have multiple sets of chromosomes, with each set containing a complete copy of the genome.

The study of plant genomes is an active area of research in modern biology, with important applications in areas such as crop improvement, evolutionary biology, and medical research. Advances in DNA sequencing technologies have made it possible to determine the complete sequences of many plant genomes, providing valuable insights into their structure, function, and evolution.

Inheritance patterns refer to the way in which a particular genetic trait or disorder is passed down from one generation to the next, following the rules of Mendelian genetics. There are several different inheritance patterns, including:

1. Autosomal dominant: A single copy of the altered gene in each cell is sufficient to cause the disorder. An affected parent has a 50% chance of passing on the altered gene to each offspring.
2. Autosomal recessive: Two copies of the altered gene in each cell are necessary for the disorder to occur. Both parents must be carriers of the altered gene and have a 25% chance of passing on the altered gene to each offspring, who may then develop the disorder.
3. X-linked dominant: The altered gene is located on the X chromosome, and one copy of the altered gene in each cell is sufficient to cause the disorder. Females are more likely to be affected than males, and an affected female has a 50% chance of passing on the altered gene to each offspring.
4. X-linked recessive: The altered gene is located on the X chromosome, and two copies of the altered gene in each cell are necessary for the disorder to occur. Males are more likely to be affected than females, and an affected male will pass on the altered gene to all of his daughters (who will be carriers) but none of his sons.
5. Mitochondrial inheritance: The altered gene is located in the mitochondria, the energy-producing structures in cells. Both males and females can pass on mitochondrial genetic disorders, but only through the female line because offspring inherit their mother's mitochondria.

Understanding inheritance patterns helps medical professionals predict the likelihood of a genetic disorder occurring in families and provides information about how a disorder may be passed down through generations.

Inbred strains of mice are defined as lines of mice that have been brother-sister mated for at least 20 consecutive generations. This results in a high degree of homozygosity, where the mice of an inbred strain are genetically identical to one another, with the exception of spontaneous mutations.

Inbred strains of mice are widely used in biomedical research due to their genetic uniformity and stability, which makes them useful for studying the genetic basis of various traits, diseases, and biological processes. They also provide a consistent and reproducible experimental system, as compared to outbred or genetically heterogeneous populations.

Some commonly used inbred strains of mice include C57BL/6J, BALB/cByJ, DBA/2J, and 129SvEv. Each strain has its own unique genetic background and phenotypic characteristics, which can influence the results of experiments. Therefore, it is important to choose the appropriate inbred strain for a given research question.

Bayes' theorem, also known as Bayes' rule or Bayes' formula, is a fundamental principle in the field of statistics and probability theory. It describes how to update the probability of a hypothesis based on new evidence or data. The theorem is named after Reverend Thomas Bayes, who first formulated it in the 18th century.

In mathematical terms, Bayes' theorem states that the posterior probability of a hypothesis (H) given some observed evidence (E) is proportional to the product of the prior probability of the hypothesis (P(H)) and the likelihood of observing the evidence given the hypothesis (P(E|H)):

Posterior Probability = P(H|E) = [P(E|H) x P(H)] / P(E)

Where:

* P(H|E): The posterior probability of the hypothesis H after observing evidence E. This is the probability we want to calculate.
* P(E|H): The likelihood of observing evidence E given that the hypothesis H is true.
* P(H): The prior probability of the hypothesis H before observing any evidence.
* P(E): The marginal likelihood or probability of observing evidence E, regardless of whether the hypothesis H is true or not. This value can be calculated as the sum of the products of the likelihood and prior probability for all possible hypotheses: P(E) = Σ[P(E|Hi) x P(Hi)]

Bayes' theorem has many applications in various fields, including medicine, where it can be used to update the probability of a disease diagnosis based on test results or other clinical findings. It is also widely used in machine learning and artificial intelligence algorithms for probabilistic reasoning and decision making under uncertainty.

In medical terms, "seeds" are often referred to as a small amount of a substance, such as a radioactive material or drug, that is inserted into a tissue or placed inside a capsule for the purpose of treating a medical condition. This can include procedures like brachytherapy, where seeds containing radioactive materials are used in the treatment of cancer to kill cancer cells and shrink tumors. Similarly, in some forms of drug delivery, seeds containing medication can be used to gradually release the drug into the body over an extended period of time.

It's important to note that "seeds" have different meanings and applications depending on the medical context. In other cases, "seeds" may simply refer to small particles or structures found in the body, such as those present in the eye's retina.

Genetic selection, also known as natural selection, is a fundamental mechanism of evolution. It refers to the process by which certain heritable traits become more or less common in a population over successive generations due to differential reproduction of organisms with those traits.

In genetic selection, traits that increase an individual's fitness (its ability to survive and reproduce) are more likely to be passed on to the next generation, while traits that decrease fitness are less likely to be passed on. This results in a gradual change in the distribution of traits within a population over time, leading to adaptation to the environment and potentially speciation.

Genetic selection can occur through various mechanisms, including viability selection (differential survival), fecundity selection (differences in reproductive success), and sexual selection (choices made by individuals during mating). The process of genetic selection is driven by environmental pressures, such as predation, competition for resources, and changes in the availability of food or habitat.

Population Genetics is a subfield of genetics that deals with the genetic composition of populations and how this composition changes over time. It involves the study of the frequency and distribution of genes and genetic variations in populations, as well as the evolutionary forces that contribute to these patterns, such as mutation, gene flow, genetic drift, and natural selection.

Population genetics can provide insights into a wide range of topics, including the history and relationships between populations, the genetic basis of diseases and other traits, and the potential impacts of environmental changes on genetic diversity. This field is important for understanding evolutionary processes at the population level and has applications in areas such as conservation biology, medical genetics, and forensic science.

Species specificity is a term used in the field of biology, including medicine, to refer to the characteristic of a biological entity (such as a virus, bacterium, or other microorganism) that allows it to interact exclusively or preferentially with a particular species. This means that the biological entity has a strong affinity for, or is only able to infect, a specific host species.

For example, HIV is specifically adapted to infect human cells and does not typically infect other animal species. Similarly, some bacterial toxins are species-specific and can only affect certain types of animals or humans. This concept is important in understanding the transmission dynamics and host range of various pathogens, as well as in developing targeted therapies and vaccines.

Disease resistance, in a medical context, refers to the inherent or acquired ability of an organism to withstand or limit infection by a pathogen, such as bacteria, viruses, fungi, or parasites. This resistance can be due to various factors including the presence of physical barriers (e.g., intact skin), chemical barriers (e.g., stomach acid), and immune responses that recognize and eliminate the pathogen.

Inherited disease resistance is often determined by genetics, where certain genetic variations can make an individual more or less susceptible to a particular infection. For example, some people are naturally resistant to certain diseases due to genetic factors that prevent the pathogen from infecting their cells or replicating within them.

Acquired disease resistance can occur through exposure to a pathogen, which triggers an immune response that confers immunity or resistance to future infections by the same pathogen. This is the basis of vaccination, where a weakened or dead form of a pathogen is introduced into the body to stimulate an immune response without causing disease.

Overall, disease resistance is an important factor in maintaining health and preventing the spread of infectious diseases.

"Outbred strains" of animals in a medical context refers to populations of animals that are not genetically identical or inbred. These animals are derived from matings between individuals from different genetic backgrounds and are characterized by a high degree of genetic variability. This genetic diversity is maintained through random mating and selection, allowing for a wide range of phenotypic traits to be expressed within the population.

Outbred strains are often used in biomedical research as they provide a more genetically diverse background compared to inbred or genetically modified animal models. This genetic diversity can help to better represent human populations and improve the translatability of research findings to clinical applications. Additionally, outbred animals may be less susceptible to certain experimental artifacts that can arise from the use of highly inbred strains, such as reduced immune function or increased susceptibility to disease.

Examples of commonly used outbred animal models include the Sprague-Dawley rat and the Swiss Webster mouse. These animals are widely used in a variety of research areas, including toxicology, pharmacology, behavioral studies, and basic biomedical research.

Genetic pleiotropy is a phenomenon in genetics where a single gene or genetic variant has multiple effects on different phenotypic traits. This means that the gene influences more than one trait, and changes in the gene can result in variations in multiple traits. The term "pleiotropy" comes from the Greek words "pleion," meaning "more," and "trope," meaning "turning."

An example of genetic pleiotropy is the gene that causes sickle cell anemia, a severe form of hemolytic anemia. This same gene also provides resistance to malaria in heterozygotes (individuals who inherit one normal and one mutated copy of the gene). Therefore, the single gene has multiple effects on different traits: red blood cell shape and susceptibility to malaria.

Understanding genetic pleiotropy is essential for understanding how complex traits are inherited and how genes contribute to various diseases and conditions. It also highlights that modifying or treating one trait may have unintended consequences on other traits influenced by the same gene.

A haplotype is a group of genes or DNA sequences that are inherited together from a single parent. It refers to a combination of alleles (variant forms of a gene) that are located on the same chromosome and are usually transmitted as a unit. Haplotypes can be useful in tracing genetic ancestry, understanding the genetic basis of diseases, and developing personalized medical treatments.

In population genetics, haplotypes are often used to study patterns of genetic variation within and between populations. By comparing haplotype frequencies across populations, researchers can infer historical events such as migrations, population expansions, and bottlenecks. Additionally, haplotypes can provide information about the evolutionary history of genes and genomic regions.

In clinical genetics, haplotypes can be used to identify genetic risk factors for diseases or to predict an individual's response to certain medications. For example, specific haplotypes in the HLA gene region have been associated with increased susceptibility to certain autoimmune diseases, while other haplotypes in the CYP450 gene family can affect how individuals metabolize drugs.

Overall, haplotypes provide a powerful tool for understanding the genetic basis of complex traits and diseases, as well as for developing personalized medical treatments based on an individual's genetic makeup.

I must clarify that the term "pedigree" is not typically used in medical definitions. Instead, it is often employed in genetics and breeding, where it refers to the recorded ancestry of an individual or a family, tracing the inheritance of specific traits or diseases. In human genetics, a pedigree can help illustrate the pattern of genetic inheritance in families over multiple generations. However, it is not a medical term with a specific clinical definition.

Genetic association studies are a type of epidemiological research that aims to identify statistical associations between genetic variations and particular traits or diseases. These studies typically compare the frequency of specific genetic markers, such as single nucleotide polymorphisms (SNPs), in individuals with a given trait or disease to those without it.

The goal of genetic association studies is to identify genetic factors that contribute to the risk of developing common complex diseases, such as diabetes, heart disease, or cancer. By identifying these genetic associations, researchers hope to gain insights into the underlying biological mechanisms of these diseases and develop new strategies for prevention, diagnosis, and treatment.

It's important to note that while genetic association studies can identify statistical associations between genetic markers and traits or diseases, they cannot prove causality. Further research is needed to confirm and validate these findings and to understand the functional consequences of the identified genetic variants.

A plant disease is a disorder that affects the normal growth and development of plants, caused by pathogenic organisms such as bacteria, viruses, fungi, parasites, or nematodes, as well as environmental factors like nutrient deficiencies, extreme temperatures, or physical damage. These diseases can cause various symptoms, including discoloration, wilting, stunted growth, necrosis, and reduced yield or productivity, which can have significant economic and ecological impacts.

Statistical models are mathematical representations that describe the relationship between variables in a given dataset. They are used to analyze and interpret data in order to make predictions or test hypotheses about a population. In the context of medicine, statistical models can be used for various purposes such as:

1. Disease risk prediction: By analyzing demographic, clinical, and genetic data using statistical models, researchers can identify factors that contribute to an individual's risk of developing certain diseases. This information can then be used to develop personalized prevention strategies or early detection methods.

2. Clinical trial design and analysis: Statistical models are essential tools for designing and analyzing clinical trials. They help determine sample size, allocate participants to treatment groups, and assess the effectiveness and safety of interventions.

3. Epidemiological studies: Researchers use statistical models to investigate the distribution and determinants of health-related events in populations. This includes studying patterns of disease transmission, evaluating public health interventions, and estimating the burden of diseases.

4. Health services research: Statistical models are employed to analyze healthcare utilization, costs, and outcomes. This helps inform decisions about resource allocation, policy development, and quality improvement initiatives.

5. Biostatistics and bioinformatics: In these fields, statistical models are used to analyze large-scale molecular data (e.g., genomics, proteomics) to understand biological processes and identify potential therapeutic targets.

In summary, statistical models in medicine provide a framework for understanding complex relationships between variables and making informed decisions based on data-driven insights.

'DBA' is an abbreviation for 'Database of Genotypes and Phenotypes,' but in the context of "Inbred DBA mice," it refers to a specific strain of laboratory mice that have been inbred for many generations. The DBA strain is one of the oldest inbred strains, and it was established in 1909 by C.C. Little at the Bussey Institute of Harvard University.

The "Inbred DBA" mice are genetically identical mice that have been produced by brother-sister matings for more than 20 generations. This extensive inbreeding results in a homozygous population, where all members of the strain have the same genetic makeup. The DBA strain is further divided into several sub-strains, including DBA/1, DBA/2, and DBA/J, among others.

DBA mice are known for their black coat color, which can fade to gray with age, and they exhibit a range of phenotypic traits that make them useful for research purposes. For example, DBA mice have a high incidence of retinal degeneration, making them a valuable model for studying eye diseases. They also show differences in behavior, immune response, and susceptibility to various diseases compared to other inbred strains.

In summary, "Inbred DBA" mice are a specific strain of laboratory mice that have been inbred for many generations, resulting in a genetically identical population with distinct phenotypic traits. They are widely used in biomedical research to study various diseases and biological processes.

I'm sorry for any confusion, but "Hordeum" is not a medical term. It is actually the genus name for barley in botany. If you have any medical terms or concepts that you would like me to explain, please let me know!

Genetic polymorphism refers to the occurrence of multiple forms (called alleles) of a particular gene within a population. These variations in the DNA sequence do not generally affect the function or survival of the organism, but they can contribute to differences in traits among individuals. Genetic polymorphisms can be caused by single nucleotide changes (SNPs), insertions or deletions of DNA segments, or other types of genetic rearrangements. They are important for understanding genetic diversity and evolution, as well as for identifying genetic factors that may contribute to disease susceptibility in humans.

I'm sorry for any confusion, but "flowers" is not a term that has a medical definition. The term "flowers" is commonly used to refer to the reproductive structures of flowering plants (angiosperms), which are characterized by having both male and female reproductive organs or separate male and female flowers.

If you have any questions related to medical terminology or health conditions, I would be happy to try to help answer those for you!

Hybrid vigor, also known as heterosis or heterozygote advantage, is a phenomenon in genetics where the offspring of genetically diverse parents exhibit certain favorable traits that are not present in either parent. This results in increased growth, fertility, disease resistance, and overall hardiness in the offspring compared to the purebred parents.

In medical terms, hybrid vigor is often discussed in the context of breeding programs for livestock or plants used for agricultural purposes. By crossing two distinct lines or breeds with different genetic backgrounds, breeders can create offspring that have improved health and productivity traits, which can lead to better outcomes in farming and agriculture.

It's worth noting that while hybrid vigor is a well-established concept in genetics, its application in human medicine is limited. However, understanding the principles of hybrid vigor can still be useful for researchers studying genetic diversity and disease susceptibility in humans.

I'm sorry for any confusion, but "flowering tops" is not a standard medical term. The term "flowering tops" is commonly used in the context of cannabis cultivation and refers to the top colas or buds of female cannabis plants that are covered in trichomes and are therefore the most potent part of the plant. If you have any questions about medical terminology, I would be happy to help clarify those for you!

Agricultural crops refer to plants that are grown and harvested for the purpose of human or animal consumption, fiber production, or other uses such as biofuels. These crops can include grains, fruits, vegetables, nuts, seeds, and legumes, among others. They are typically cultivated using various farming practices, including traditional row cropping, companion planting, permaculture, and organic farming methods. The choice of crop and farming method depends on factors such as the local climate, soil conditions, and market demand. Proper management of agricultural crops is essential for ensuring food security, promoting sustainable agriculture, and protecting the environment.

Genomics is the scientific study of genes and their functions. It involves the sequencing and analysis of an organism's genome, which is its complete set of DNA, including all of its genes. Genomics also includes the study of how genes interact with each other and with the environment. This field of study can provide important insights into the genetic basis of diseases and can lead to the development of new diagnostic tools and treatments.

A human genome is the complete set of genetic information contained within the 23 pairs of chromosomes found in the nucleus of most human cells. It includes all of the genes, which are segments of DNA that contain the instructions for making proteins, as well as non-coding regions of DNA that regulate gene expression and provide structural support to the chromosomes.

The human genome contains approximately 3 billion base pairs of DNA and is estimated to contain around 20,000-25,000 protein-coding genes. The sequencing of the human genome was completed in 2003 as part of the Human Genome Project, which has had a profound impact on our understanding of human biology, disease, and evolution.

Gene frequency, also known as allele frequency, is a measure in population genetics that reflects the proportion of a particular gene or allele (variant of a gene) in a given population. It is calculated as the number of copies of a specific allele divided by the total number of all alleles at that genetic locus in the population.

For example, if we consider a gene with two possible alleles, A and a, the gene frequency of allele A (denoted as p) can be calculated as follows:

p = (number of copies of allele A) / (total number of all alleles at that locus)

Similarly, the gene frequency of allele a (denoted as q) would be:

q = (number of copies of allele a) / (total number of all alleles at that locus)

Since there are only two possible alleles for this gene in this example, p + q = 1. These frequencies can help researchers understand genetic diversity and evolutionary processes within populations.

I'm sorry for any confusion, but the "Monte Carlo method" is actually a term from the field of mathematics and computer science, not medicine. It refers to a statistical technique that allows for the modeling of complex systems by running multiple simulations with random inputs. This method is widely used in various fields such as physics, engineering, and finance, but it is not a medical concept or term.

Inbreeding in animals refers to the mating of closely related individuals, such as siblings or offspring of siblings, over multiple generations. An inbred strain is a population of animals produced by this repeated mating of close relatives, which results in a high degree of genetic similarity among members of the strain.

Inbreeding can lead to an increase in homozygosity, where identical alleles are present at corresponding loci on both chromosomes. This can result in the expression of recessive traits, some of which may be deleterious or even lethal. However, inbred strains also have advantages, such as reduced genetic variability, which makes them useful for scientific research.

Inbred strains are commonly used in biomedical research, including genetics, immunology, and behavioral studies. They provide a consistent and controlled genetic background, allowing researchers to study the effects of specific genes or environmental factors with greater precision. Additionally, inbred strains can be crossed with other strains to create hybrid populations, which can be used to map quantitative trait loci (QTL) and identify genes associated with complex traits.

C57BL/6 (C57 Black 6) is an inbred strain of laboratory mouse that is widely used in biomedical research. The term "inbred" refers to a strain of animals where matings have been carried out between siblings or other closely related individuals for many generations, resulting in a population that is highly homozygous at most genetic loci.

The C57BL/6 strain was established in 1920 by crossing a female mouse from the dilute brown (DBA) strain with a male mouse from the black strain. The resulting offspring were then interbred for many generations to create the inbred C57BL/6 strain.

C57BL/6 mice are known for their robust health, longevity, and ease of handling, making them a popular choice for researchers. They have been used in a wide range of biomedical research areas, including studies of cancer, immunology, neuroscience, cardiovascular disease, and metabolism.

One of the most notable features of the C57BL/6 strain is its sensitivity to certain genetic modifications, such as the introduction of mutations that lead to obesity or impaired glucose tolerance. This has made it a valuable tool for studying the genetic basis of complex diseases and traits.

Overall, the C57BL/6 inbred mouse strain is an important model organism in biomedical research, providing a valuable resource for understanding the genetic and molecular mechanisms underlying human health and disease.

Gene expression profiling is a laboratory technique used to measure the activity (expression) of thousands of genes at once. This technique allows researchers and clinicians to identify which genes are turned on or off in a particular cell, tissue, or organism under specific conditions, such as during health, disease, development, or in response to various treatments.

The process typically involves isolating RNA from the cells or tissues of interest, converting it into complementary DNA (cDNA), and then using microarray or high-throughput sequencing technologies to determine which genes are expressed and at what levels. The resulting data can be used to identify patterns of gene expression that are associated with specific biological states or processes, providing valuable insights into the underlying molecular mechanisms of diseases and potential targets for therapeutic intervention.

In recent years, gene expression profiling has become an essential tool in various fields, including cancer research, drug discovery, and personalized medicine, where it is used to identify biomarkers of disease, predict patient outcomes, and guide treatment decisions.

Genetic recombination is the process by which genetic material is exchanged between two similar or identical molecules of DNA during meiosis, resulting in new combinations of genes on each chromosome. This exchange occurs during crossover, where segments of DNA are swapped between non-sister homologous chromatids, creating genetic diversity among the offspring. It is a crucial mechanism for generating genetic variability and facilitating evolutionary change within populations. Additionally, recombination also plays an essential role in DNA repair processes through mechanisms such as homologous recombinational repair (HRR) and non-homologous end joining (NHEJ).

'Brassica napus' is the scientific name for a species of plant that includes both rapeseed and canola. It is a type of cruciferous vegetable that is widely cultivated for its seeds, which are used to produce oil, as well as for its leaves and stems, which are eaten as vegetables in some parts of the world.

Rapeseed oil, which is produced from the seeds of 'Brassica napus', has historically been used as a source of industrial lubricant and as a fuel for diesel engines. However, modern canola oil, which is also produced from 'Brassica napus' but has been bred to have lower levels of erucic acid and glucosinolates, is more commonly used as a food oil due to its mild flavor and high smoke point.

The leaves and stems of 'Brassica napus' are also edible and are commonly consumed in parts of Europe and Asia. They can be prepared in a variety of ways, including boiling, steaming, or stir-frying. The plant is also sometimes used as a cover crop or green manure due to its ability to improve soil health and reduce erosion.

"Triticum" is the genus name for a group of cereal grains that includes common wheat (T. aestivum), durum wheat (T. durum), and spelt (T. spelta). These grains are important sources of food for humans, providing carbohydrates, proteins, and various nutrients. They are used to make a variety of foods such as bread, pasta, and breakfast cereals. Triticum species are also known as "wheat" in layman's terms.

'Arabidopsis' is a genus of small flowering plants that are part of the mustard family (Brassicaceae). The most commonly studied species within this genus is 'Arabidopsis thaliana', which is often used as a model organism in plant biology and genetics research. This plant is native to Eurasia and Africa, and it has a small genome that has been fully sequenced. It is known for its short life cycle, self-fertilization, and ease of growth, making it an ideal subject for studying various aspects of plant biology, including development, metabolism, and response to environmental stresses.

In a medical context, "meat" generally refers to the flesh of animals that is consumed as food. This includes muscle tissue, as well as fat and other tissues that are often found in meat products. However, it's worth noting that some people may have dietary restrictions or medical conditions that prevent them from consuming meat, so it's always important to consider individual preferences and needs when discussing food options.

It's also worth noting that the consumption of meat can have both positive and negative health effects. On the one hand, meat is a good source of protein, iron, vitamin B12, and other essential nutrients. On the other hand, consuming large amounts of red and processed meats has been linked to an increased risk of heart disease, stroke, and certain types of cancer. Therefore, it's generally recommended to consume meat in moderation as part of a balanced diet.

The term "environment" in a medical context generally refers to the external conditions and surroundings that can have an impact on living organisms, including humans. This includes both physical factors such as air quality, water supply, soil composition, temperature, and radiation, as well as biological factors such as the presence of microorganisms, plants, and animals.

In public health and epidemiology, the term "environmental exposure" is often used to describe the contact between an individual and a potentially harmful environmental agent, such as air pollution or contaminated water. These exposures can have significant impacts on human health, contributing to a range of diseases and disorders, including respiratory illnesses, cancer, neurological disorders, and reproductive problems.

Efforts to protect and improve the environment are therefore critical for promoting human health and preventing disease. This includes measures to reduce pollution, conserve natural resources, promote sustainable development, and mitigate the impacts of climate change.

"Mimulus" is a term used in the context of botany, rather than medicine. It refers to a genus of plants commonly known as "monkey flowers," which belong to the Phrymaceae family. These plants are native to North and South America and are known for their vibrant, tubular flowers that attract pollinators such as hummingbirds and bees.

While "Mimulus" is not a medical term, some species of this plant have been used in traditional medicine by indigenous peoples. For example, Mimulus guttatus (the common monkey flower) has been used in Native American medicine for treating respiratory issues, skin irritations, and gastrointestinal problems. However, it's important to note that the use of these plants as medicinal remedies should not be considered a substitute for seeking advice from a licensed healthcare professional or following evidence-based medical treatments.

I believe there may be a slight misunderstanding in your question. "Plant leaves" are not a medical term, but rather a general biological term referring to a specific organ found in plants.

Leaves are organs that are typically flat and broad, and they are the primary site of photosynthesis in most plants. They are usually green due to the presence of chlorophyll, which is essential for capturing sunlight and converting it into chemical energy through photosynthesis.

While leaves do not have a direct medical definition, understanding their structure and function can be important in various medical fields, such as pharmacognosy (the study of medicinal plants) or environmental health. For example, certain plant leaves may contain bioactive compounds that have therapeutic potential, while others may produce allergens or toxins that can impact human health.

An algorithm is not a medical term, but rather a concept from computer science and mathematics. In the context of medicine, algorithms are often used to describe step-by-step procedures for diagnosing or managing medical conditions. These procedures typically involve a series of rules or decision points that help healthcare professionals make informed decisions about patient care.

For example, an algorithm for diagnosing a particular type of heart disease might involve taking a patient's medical history, performing a physical exam, ordering certain diagnostic tests, and interpreting the results in a specific way. By following this algorithm, healthcare professionals can ensure that they are using a consistent and evidence-based approach to making a diagnosis.

Algorithms can also be used to guide treatment decisions. For instance, an algorithm for managing diabetes might involve setting target blood sugar levels, recommending certain medications or lifestyle changes based on the patient's individual needs, and monitoring the patient's response to treatment over time.

Overall, algorithms are valuable tools in medicine because they help standardize clinical decision-making and ensure that patients receive high-quality care based on the latest scientific evidence.

Body weight is the measure of the force exerted on a scale or balance by an object's mass, most commonly expressed in units such as pounds (lb) or kilograms (kg). In the context of medical definitions, body weight typically refers to an individual's total weight, which includes their skeletal muscle, fat, organs, and bodily fluids.

Healthcare professionals often use body weight as a basic indicator of overall health status, as it can provide insights into various aspects of a person's health, such as nutritional status, metabolic function, and risk factors for certain diseases. For example, being significantly underweight or overweight can increase the risk of developing conditions like malnutrition, diabetes, heart disease, and certain types of cancer.

It is important to note that body weight alone may not provide a complete picture of an individual's health, as it does not account for factors such as muscle mass, bone density, or body composition. Therefore, healthcare professionals often use additional measures, such as body mass index (BMI), waist circumference, and blood tests, to assess overall health status more comprehensively.

DNA, or deoxyribonucleic acid, is the genetic material present in the cells of all living organisms, including plants. In plants, DNA is located in the nucleus of a cell, as well as in chloroplasts and mitochondria. Plant DNA contains the instructions for the development, growth, and function of the plant, and is passed down from one generation to the next through the process of reproduction.

The structure of DNA is a double helix, formed by two strands of nucleotides that are linked together by hydrogen bonds. Each nucleotide contains a sugar molecule (deoxyribose), a phosphate group, and a nitrogenous base. There are four types of nitrogenous bases in DNA: adenine (A), guanine (G), cytosine (C), and thymine (T). Adenine pairs with thymine, and guanine pairs with cytosine, forming the rungs of the ladder that make up the double helix.

The genetic information in DNA is encoded in the sequence of these nitrogenous bases. Large sequences of bases form genes, which provide the instructions for the production of proteins. The process of gene expression involves transcribing the DNA sequence into a complementary RNA molecule, which is then translated into a protein.

Plant DNA is similar to animal DNA in many ways, but there are also some differences. For example, plant DNA contains a higher proportion of repetitive sequences and transposable elements, which are mobile genetic elements that can move around the genome and cause mutations. Additionally, plant cells have cell walls and chloroplasts, which are not present in animal cells, and these structures contain their own DNA.

Glucosinolates are naturally occurring compounds found in various plants, particularly in cruciferous vegetables such as broccoli, Brussels sprouts, cabbage, and mustard greens. They are sulfur-containing glucosides that can be hydrolyzed by the enzyme myrosinase when the plant tissue is damaged, leading to the formation of biologically active compounds like isothiocyanates, thiocyanates, and nitriles. These breakdown products have been shown to exhibit various health benefits, such as anti-cancer, anti-inflammatory, and antimicrobial activities. However, excessive intake or exposure may also cause adverse effects in some individuals.

'Sus scrofa' is the scientific name for the wild boar, a species of suid that is native to much of Eurasia and North Africa. It is not a medical term or concept. If you have any questions related to medical terminology or health-related topics, I would be happy to help with those instead!

Heredity, in medical terms, refers to the passing on of genetic characteristics from parents to their offspring through the transmission of genes. These genes carry the information that determines many traits, such as eye color, hair color, height, and certain health conditions. Heredity plays a significant role in understanding the causes of various diseases and disorders, as some are strongly influenced by genetic factors. However, it's important to note that environmental factors can also interact with genetic predispositions to influence the expression of these traits.

'Brassica rapa' is the scientific name for a species of plant that includes various types of vegetables such as turnips, Chinese cabbages, and bok choy. It is a member of the Brassicaceae family, also known as the mustard or cabbage family. The plants in this species are characterized by their broad leaves and branching stem, and they are native to Europe and Central Asia.

Turnips, which are one of the most common vegetables in this species, are cool-season root crops that are grown for their enlarged taproot. They have a white or yellowish flesh that is crisp and tender with a sweet, slightly bitter flavor. Turnips can be eaten raw or cooked and are often used in soups, stews, and casseroles.

Chinese cabbages, also known as Napa cabbages, are another type of vegetable in the 'Brassica rapa' species. They have elongated, pale green leaves that form a compact head, and they are often used in Asian cuisine. Chinese cabbages have a mild flavor and can be eaten raw or cooked.

Bok choy, also known as pak choi, is another type of vegetable in the 'Brassica rapa' species. It has dark green leaves and white stems, and it is often used in stir-fries and soups. Bok choy has a mild flavor and a crisp texture.

Overall, 'Brassica rapa' is an important species of plant that includes many nutritious and delicious vegetables that are popular around the world.

"Solanum" is a genus of flowering plants that includes many species, some of which are economically important as food crops and others which are toxic. The term "Solanum" itself does not have a specific medical definition, but several species within this genus are relevant to medicine and human health. Here are some examples:

1. Solanum lycopersicum (tomato): While tomatoes are primarily known as a food crop, they also contain various compounds with potential medicinal properties. For instance, they are rich in antioxidants like lycopene, which has been studied for its potential benefits in preventing cancer and cardiovascular diseases.
2. Solanum tuberosum (potato): Potatoes are a staple food crop, but their leaves and green parts contain solanine, a toxic alkaloid that can cause gastrointestinal disturbances, neurological symptoms, and even death in severe cases.
3. Solanum melongena (eggplant): Eggplants have been studied for their potential health benefits due to their high antioxidant content, including nasunin, which has been shown to protect against lipid peroxidation and DNA damage.
4. Solanum nigrum (black nightshade): This species contains solanine and other toxic alkaloids, but some parts of the plant have been used in traditional medicine for their anti-inflammatory, analgesic, and antipyretic properties. However, its use as a medicinal herb is not well-established, and it can be toxic if improperly prepared or consumed in large quantities.
5. Solanum dulcamara (bittersweet nightshade): This species has been used in traditional medicine for various purposes, including treating skin conditions, respiratory ailments, and gastrointestinal complaints. However, its use as a medicinal herb is not well-supported by scientific evidence, and it can be toxic if ingested in large quantities.

In summary, "Solanum" refers to a genus of flowering plants that includes several species with relevance to medicine and human health. While some species are important food crops, others contain toxic compounds that can cause harm if improperly consumed or prepared. Additionally, the medicinal use of some Solanum species is not well-established and may carry risks.

DNA Sequence Analysis is the systematic determination of the order of nucleotides in a DNA molecule. It is a critical component of modern molecular biology, genetics, and genetic engineering. The process involves determining the exact order of the four nucleotide bases - adenine (A), guanine (G), cytosine (C), and thymine (T) - in a DNA molecule or fragment. This information is used in various applications such as identifying gene mutations, studying evolutionary relationships, developing molecular markers for breeding, and diagnosing genetic diseases.

The process of DNA Sequence Analysis typically involves several steps, including DNA extraction, PCR amplification (if necessary), purification, sequencing reaction, and electrophoresis. The resulting data is then analyzed using specialized software to determine the exact sequence of nucleotides.

In recent years, high-throughput DNA sequencing technologies have revolutionized the field of genomics, enabling the rapid and cost-effective sequencing of entire genomes. This has led to an explosion of genomic data and new insights into the genetic basis of many diseases and traits.

A nuclear family, in medical and social sciences, refers to a family structure consisting of two married parents and their biological or adopted children living together in one household. It's the basic unit of a traditional family structure, typically comprising of a father (male parent), a mother (female parent) and their direct offspring. However, it's important to note that there are many different types of families and none is considered universally superior or normative. The concept of a nuclear family has evolved over time and varies across cultures and societies.

"Rats, Inbred BN" are a strain of laboratory rats (Rattus norvegicus) that have been inbred for many generations to maintain a high level of genetic consistency and uniformity within the strain. The "BN" designation refers to the place where they were first developed, Bratislava, Czechoslovakia (now Slovakia).

These rats are often used in biomedical research because their genetic homogeneity makes them useful for studying the effects of specific genes or environmental factors on health and disease. They have been widely used as a model organism to study various physiological and pathophysiological processes, including hypertension, kidney function, immunology, and neuroscience.

Inbred BN rats are known for their low renin-angiotensin system activity, which makes them a useful model for studying hypertension and related disorders. They also have a unique sensitivity to dietary protein, making them a valuable tool for studying the relationship between diet and kidney function.

Overall, Inbred BN rats are an important tool in biomedical research, providing researchers with a consistent and well-characterized model organism for studying various aspects of human health and disease.

Synteny, in the context of genetics and genomics, refers to the presence of two or more genetic loci (regions) on the same chromosome, in the same relative order and orientation. This term is often used to describe conserved gene organization between different species, indicating a common ancestry.

It's important to note that synteny should not be confused with "colinearity," which refers to the conservation of gene content and order within a genome or between genomes of closely related species. Synteny is a broader concept that can also include conserved gene order across more distantly related species, even if some genes have been lost or gained in the process.

In medical research, synteny analysis can be useful for identifying conserved genetic elements and regulatory regions that may play important roles in disease susceptibility or other biological processes.

'Rats, Inbred Dahl' are a strain of laboratory rats that have been selectively bred for research purposes. They were first developed by Dr. Lewis L. Dahl in the 1960s at the University of Colorado School of Medicine. These rats are known for their susceptibility to develop high blood pressure (hypertension) and related cardiovascular diseases, making them a valuable model for studying hypertension and its complications.

Inbred Dahl rats are typically divided into two main strains: the Dahl Salt-Sensitive (SS/JrHsdMcwi or SS) rat and the Dahl Salt-Resistant (SR/JrHsdMcwi or SR) rat. When fed a high-salt diet, the SS rats develop severe hypertension, kidney damage, and cardiac hypertrophy, while the SR rats are relatively resistant to these effects.

The Inbred Dahl rats have contributed significantly to our understanding of the genetic and environmental factors that contribute to the development of hypertension and related disorders. They continue to be widely used in biomedical research today.

Molecular sequence data refers to the specific arrangement of molecules, most commonly nucleotides in DNA or RNA, or amino acids in proteins, that make up a biological macromolecule. This data is generated through laboratory techniques such as sequencing, and provides information about the exact order of the constituent molecules. This data is crucial in various fields of biology, including genetics, evolution, and molecular biology, allowing for comparisons between different organisms, identification of genetic variations, and studies of gene function and regulation.

Haploidy is a term used in genetics to describe the condition of having half the normal number of chromosomes in a cell or an organism. In humans, for example, a haploid cell contains 23 chromosomes, whereas a diploid cell has 46 chromosomes.

Haploid cells are typically produced through a process called meiosis, which is a type of cell division that occurs in the reproductive organs of sexually reproducing organisms. During meiosis, a diploid cell undergoes two rounds of division to produce four haploid cells, each containing only one set of chromosomes.

In humans, haploid cells are found in the sperm and egg cells, which fuse together during fertilization to create a diploid zygote with 46 chromosomes. Haploidy is important for maintaining the correct number of chromosomes in future generations and preventing genetic abnormalities that can result from having too many or too few chromosomes.

"Lycopersicon esculentum" is the scientific name for the common red tomato. It is a species of fruit from the nightshade family (Solanaceae) that is native to western South America and Central America. Tomatoes are widely grown and consumed in many parts of the world as a vegetable, although they are technically a fruit. They are rich in nutrients such as vitamin C, potassium, and lycopene, which has been studied for its potential health benefits.

Canine hip dysplasia (CHD) is a common skeletal disorder in dogs, particularly in large and giant breeds, characterized by the abnormal development and degeneration of the coxofemoral joint - the joint where the head of the femur (thigh bone) meets the acetabulum (hip socket) of the pelvis. This condition is often caused by a combination of genetic and environmental factors that lead to laxity (looseness) of the joint, which can result in osteoarthritis (OA), pain, and decreased mobility over time.

In a healthy hip joint, the femoral head fits snugly into the acetabulum, allowing smooth and stable movement. However, in dogs with CHD, the following abnormalities may occur:

1. Shallow acetabulum: The hip socket may not be deep enough to provide adequate coverage of the femoral head, leading to joint instability.
2. Flared acetabulum: The rim of the acetabulum may become stretched and flared due to excessive forces exerted on it by the lax joint.
3. Misshapen or malformed femoral head: The femoral head may not have a normal round shape, further contributing to joint instability.
4. Laxity of the joint: The ligament that holds the femoral head in place within the acetabulum (ligamentum teres) can become stretched, allowing for excessive movement and abnormal wear of the joint surfaces.

These changes can lead to the development of osteoarthritis, which is characterized by the breakdown and loss of cartilage within the joint, as well as the formation of bone spurs (osteophytes) and thickening of the joint capsule. This results in pain, stiffness, and decreased range of motion, making it difficult for affected dogs to perform everyday activities such as walking, running, or climbing stairs.

Canine hip dysplasia is typically diagnosed through a combination of physical examination, medical history, and imaging techniques such as radiographs (X-rays). Treatment options may include conservative management, such as weight management, exercise modification, joint supplements, and pain medication, or surgical intervention, such as total hip replacement. The choice of treatment depends on the severity of the disease, the age and overall health of the dog, and the owner's financial resources.

Preventing canine hip dysplasia is best achieved through selective breeding practices that aim to eliminate affected animals from breeding populations. Additionally, maintaining a healthy weight, providing appropriate exercise, and ensuring proper nutrition throughout a dog's life can help reduce the risk of developing this debilitating condition.

"Cattle" is a term used in the agricultural and veterinary fields to refer to domesticated animals of the genus *Bos*, primarily *Bos taurus* (European cattle) and *Bos indicus* (Zebu). These animals are often raised for meat, milk, leather, and labor. They are also known as bovines or cows (for females), bulls (intact males), and steers/bullocks (castrated males). However, in a strict medical definition, "cattle" does not apply to humans or other animals.

Statistical data interpretation involves analyzing and interpreting numerical data in order to identify trends, patterns, and relationships. This process often involves the use of statistical methods and tools to organize, summarize, and draw conclusions from the data. The goal is to extract meaningful insights that can inform decision-making, hypothesis testing, or further research.

In medical contexts, statistical data interpretation is used to analyze and make sense of large sets of clinical data, such as patient outcomes, treatment effectiveness, or disease prevalence. This information can help healthcare professionals and researchers better understand the relationships between various factors that impact health outcomes, develop more effective treatments, and identify areas for further study.

Some common statistical methods used in data interpretation include descriptive statistics (e.g., mean, median, mode), inferential statistics (e.g., hypothesis testing, confidence intervals), and regression analysis (e.g., linear, logistic). These methods can help medical professionals identify patterns and trends in the data, assess the significance of their findings, and make evidence-based recommendations for patient care or public health policy.

Radiation hybrid (RH) mapping is a genetic mapping technique used to determine the relative order and distance between DNA markers or genes on a chromosome. This technique involves exposing donor cells, which contain the chromosome of interest, to high-dose radiation. The radiation causes breaks in the chromosomes, which are then repaired by fusing the donor cells with irradiated hamster cells (the recipient cells).

During the repair process, the broken chromosomal fragments from the donor cell randomly assort and integrate into the genome of the recipient cell. The resulting hybrid cells contain a mosaic of donor chromosomal fragments, which can be analyzed to determine the order and distance between DNA markers or genes on the original chromosome.

The frequency of co-occurrence of two markers in the same hybrid cell is used as an estimate of their physical proximity on the chromosome. The greater the frequency of co-occurrence, the closer the two markers are assumed to be. RH mapping can provide high-resolution maps of large genomes and has been widely used for mapping human and other mammalian genomes. However, with the advent of next-generation sequencing technologies, RH mapping has largely been replaced by sequence-based methods such as whole-genome sequencing and optical mapping.

I'm sorry for any confusion, but "Markov Chains" is a term from the field of mathematics and probability theory, not medicine. Markov Chains are mathematical systems that undergo transitions from one state to another according to certain probabilistic rules. They are named after Russian mathematician Andrey Markov. These chains are used in various fields, including computer science, physics, economics, and engineering, but not commonly in medical definitions or contexts.

I'm sorry for any confusion, but "Sorghum" is not a medical term. It is actually the name of a genus of various grasses, one species of which is cultivated as a cereal crop. Sorghum is primarily used for food, animal feed, and the production of biofuel. If you have any questions about medical terminology or health-related topics, I'd be happy to help with those instead!

An ecotype is a population of a species that is adapted to specific environmental conditions and exhibits genetic differences from other populations of the same species that live in different environments. These genetic adaptations allow the ecotype to survive and reproduce more successfully in its particular habitat compared to other populations. The term "ecotype" was first introduced by botanist John Gregor Mendel in 1870 to describe the variation within plant species due to environmental factors.

Ecotypes can be found in various organisms, including plants, animals, and microorganisms. They are often studied in ecology and evolutionary biology to understand how genetic differences arise and evolve in response to environmental pressures. Ecotypes can differ from each other in traits such as morphology, physiology, behavior, and life history strategies.

Examples of ecotypes include:

* Desert and coastal ecotypes of the lizard Uta stansburiana, which show differences in body size, limb length, and reproductive strategies due to adaptation to different habitats.
* Arctic and alpine ecotypes of the plant Arabis alpina, which have distinct flowering times and cold tolerance mechanisms that help them survive in their respective environments.
* Freshwater and marine ecotypes of the copepod Eurytemora affinis, which differ in body size, developmental rate, and salinity tolerance due to adaptation to different aquatic habitats.

It is important to note that the concept of ecotype is not always clearly defined or consistently applied in scientific research. Some researchers use it to describe any population that shows genetic differences related to environmental factors, while others reserve it for cases where there is strong evidence of local adaptation and reproductive isolation between populations.

A genetic database is a type of biomedical or health informatics database that stores and organizes genetic data, such as DNA sequences, gene maps, genotypes, haplotypes, and phenotype information. These databases can be used for various purposes, including research, clinical diagnosis, and personalized medicine.

There are different types of genetic databases, including:

1. Genomic databases: These databases store whole genome sequences, gene expression data, and other genomic information. Examples include the National Center for Biotechnology Information's (NCBI) GenBank, the European Nucleotide Archive (ENA), and the DNA Data Bank of Japan (DDBJ).
2. Gene databases: These databases contain information about specific genes, including their location, function, regulation, and evolution. Examples include the Online Mendelian Inheritance in Man (OMIM) database, the Universal Protein Resource (UniProt), and the Gene Ontology (GO) database.
3. Variant databases: These databases store information about genetic variants, such as single nucleotide polymorphisms (SNPs), insertions/deletions (INDELs), and copy number variations (CNVs). Examples include the Database of Single Nucleotide Polymorphisms (dbSNP), the Catalogue of Somatic Mutations in Cancer (COSMIC), and the International HapMap Project.
4. Clinical databases: These databases contain genetic and clinical information about patients, such as their genotype, phenotype, family history, and response to treatments. Examples include the ClinVar database, the Pharmacogenomics Knowledgebase (PharmGKB), and the Genetic Testing Registry (GTR).
5. Population databases: These databases store genetic information about different populations, including their ancestry, demographics, and genetic diversity. Examples include the 1000 Genomes Project, the Human Genome Diversity Project (HGDP), and the Allele Frequency Net Database (AFND).

Genetic databases can be publicly accessible or restricted to authorized users, depending on their purpose and content. They play a crucial role in advancing our understanding of genetics and genomics, as well as improving healthcare and personalized medicine.

Genetic techniques refer to a variety of methods and tools used in the field of genetics to study, manipulate, and understand genes and their functions. These techniques can be broadly categorized into those that allow for the identification and analysis of specific genes or genetic variations, and those that enable the manipulation of genes in order to understand their function or to modify them for therapeutic purposes.

Some examples of genetic analysis techniques include:

1. Polymerase Chain Reaction (PCR): a method used to amplify specific DNA sequences, allowing researchers to study small amounts of DNA.
2. Genome sequencing: the process of determining the complete DNA sequence of an organism's genome.
3. Genotyping: the process of identifying and analyzing genetic variations or mutations in an individual's DNA.
4. Linkage analysis: a method used to identify genetic loci associated with specific traits or diseases by studying patterns of inheritance within families.
5. Expression profiling: the measurement of gene expression levels in cells or tissues, often using microarray technology.

Some examples of genetic manipulation techniques include:

1. Gene editing: the use of tools such as CRISPR-Cas9 to modify specific genes or genetic sequences.
2. Gene therapy: the introduction of functional genes into cells or tissues to replace missing or nonfunctional genes.
3. Transgenic technology: the creation of genetically modified organisms (GMOs) by introducing foreign DNA into their genomes.
4. RNA interference (RNAi): the use of small RNA molecules to silence specific genes and study their function.
5. Induced pluripotent stem cells (iPSCs): the creation of stem cells from adult cells through genetic reprogramming, allowing for the study of development and disease in vitro.

"Swine" is a common term used to refer to even-toed ungulates of the family Suidae, including domestic pigs and wild boars. However, in a medical context, "swine" often appears in the phrase "swine flu," which is a strain of influenza virus that typically infects pigs but can also cause illness in humans. The 2009 H1N1 pandemic was caused by a new strain of swine-origin influenza A virus, which was commonly referred to as "swine flu." It's important to note that this virus is not transmitted through eating cooked pork products; it spreads from person to person, mainly through respiratory droplets produced when an infected person coughs or sneezes.

Gene expression regulation in plants refers to the processes that control the production of proteins and RNA from the genes present in the plant's DNA. This regulation is crucial for normal growth, development, and response to environmental stimuli in plants. It can occur at various levels, including transcription (the first step in gene expression, where the DNA sequence is copied into RNA), RNA processing (such as alternative splicing, which generates different mRNA molecules from a single gene), translation (where the information in the mRNA is used to produce a protein), and post-translational modification (where proteins are chemically modified after they have been synthesized).

In plants, gene expression regulation can be influenced by various factors such as hormones, light, temperature, and stress. Plants use complex networks of transcription factors, chromatin remodeling complexes, and small RNAs to regulate gene expression in response to these signals. Understanding the mechanisms of gene expression regulation in plants is important for basic research, as well as for developing crops with improved traits such as increased yield, stress tolerance, and disease resistance.

Human chromosome pair 1 refers to the first pair of chromosomes in a set of 23 pairs found in the cells of the human body, excluding sex cells (sperm and eggs). Each cell in the human body, except for the gametes, contains 46 chromosomes arranged in 23 pairs. These chromosomes are rod-shaped structures that contain genetic information in the form of DNA.

Chromosome pair 1 is the largest pair, making up about 8% of the total DNA in a cell. Each chromosome in the pair consists of two arms - a shorter p arm and a longer q arm - connected at a centromere. Chromosome 1 carries an estimated 2,000-2,500 genes, which are segments of DNA that contain instructions for making proteins or regulating gene expression.

Defects or mutations in the genes located on chromosome 1 can lead to various genetic disorders and diseases, such as Charcot-Marie-Tooth disease type 1A, Huntington's disease, and certain types of cancer.

Human chromosome pair 2 consists of two rod-shaped structures present in the nucleus of each cell of the human body. Each member of the pair contains thousands of genes and other genetic material, encoded in the form of DNA molecules. Chromosomes are the physical carriers of inheritance, and human cells typically contain 23 pairs of chromosomes for a total of 46 chromosomes.

Chromosome pair 2 is one of the autosomal pairs, meaning that it is not a sex chromosome (X or Y). Each member of chromosome pair 2 is approximately 247 million base pairs in length and contains an estimated 1,000-1,300 genes. These genes play crucial roles in various biological processes, including development, metabolism, and response to environmental stimuli.

Abnormalities in chromosome pair 2 can lead to genetic disorders, such as cat-eye syndrome (CES), which is characterized by iris abnormalities, anal atresia, hearing loss, and intellectual disability. This disorder arises from the presence of an extra copy of a small region on chromosome 2, resulting in partial trisomy of this region. Other genetic conditions associated with chromosome pair 2 include proximal 2q13.3 microdeletion syndrome and Potocki-Lupski syndrome (PTLS).

Dominant genes refer to the alleles (versions of a gene) that are fully expressed in an individual's phenotype, even if only one copy of the gene is present. In dominant inheritance patterns, an individual needs only to receive one dominant allele from either parent to express the associated trait. This is in contrast to recessive genes, where both copies of the gene must be the recessive allele for the trait to be expressed. Dominant genes are represented by uppercase letters (e.g., 'A') and recessive genes by lowercase letters (e.g., 'a'). If an individual inherits one dominant allele (A) from either parent, they will express the dominant trait (A).

"Drought" is not a medical term. It is a term used in meteorology and environmental science to refer to a prolonged period of abnormally low rainfall, leading to water shortage and scarcity in the affected areas. Droughts can have various impacts on human health, including dehydration, heat-related illnesses, reduced air quality, increased transmission of waterborne diseases, and mental health issues related to stress and displacement. However, drought itself is not a medical condition.

I am not aware of a widely accepted medical definition for the term "software," as it is more commonly used in the context of computer science and technology. Software refers to programs, data, and instructions that are used by computers to perform various tasks. It does not have direct relevance to medical fields such as anatomy, physiology, or clinical practice. If you have any questions related to medicine or healthcare, I would be happy to try to help with those instead!

Analysis of Variance (ANOVA) is a statistical technique used to compare the means of two or more groups and determine whether there are any significant differences between them. It is a way to analyze the variance in a dataset to determine whether the variability between groups is greater than the variability within groups, which can indicate that the groups are significantly different from one another.

ANOVA is based on the concept of partitioning the total variance in a dataset into two components: variance due to differences between group means (also known as "between-group variance") and variance due to differences within each group (also known as "within-group variance"). By comparing these two sources of variance, ANOVA can help researchers determine whether any observed differences between groups are statistically significant, or whether they could have occurred by chance.

ANOVA is a widely used technique in many areas of research, including biology, psychology, engineering, and business. It is often used to compare the means of two or more experimental groups, such as a treatment group and a control group, to determine whether the treatment had a significant effect. ANOVA can also be used to compare the means of different populations or subgroups within a population, to identify any differences that may exist between them.

'C3H' is the name of an inbred strain of laboratory mice that was developed at the Jackson Laboratory in Bar Harbor, Maine. The mice are characterized by their uniform genetic background and have been widely used in biomedical research for many decades.

The C3H strain is particularly notable for its susceptibility to certain types of cancer, including mammary tumors and lymphomas. It also has a high incidence of age-related macular degeneration and other eye diseases. The strain is often used in studies of immunology, genetics, and carcinogenesis.

Like all inbred strains, the C3H mice are the result of many generations of brother-sister matings, which leads to a high degree of genetic uniformity within the strain. This makes them useful for studying the effects of specific genes or environmental factors on disease susceptibility and other traits. However, it also means that they may not always be representative of the genetic diversity found in outbred populations, including humans.

A heterozygote is an individual who has inherited two different alleles (versions) of a particular gene, one from each parent. This means that the individual's genotype for that gene contains both a dominant and a recessive allele. The dominant allele will be expressed phenotypically (outwardly visible), while the recessive allele may or may not have any effect on the individual's observable traits, depending on the specific gene and its function. Heterozygotes are often represented as 'Aa', where 'A' is the dominant allele and 'a' is the recessive allele.

Eucalyptus is defined in medical terms as a genus of mostly Australian trees and shrubs that have aromatic leaves and bark, and oil-containing foliage. The oil from eucalyptus leaves contains a chemical called eucalyptol, which has been found to have several medicinal properties.

Eucalyptus oil has been used in traditional medicine for centuries to treat various health conditions such as respiratory problems, fever, and pain. It has anti-inflammatory, antispasmodic, decongestant, and expectorant properties, making it a popular remedy for colds, coughs, and congestion.

Eucalyptus oil is also used in modern medicine as an ingredient in over-the-counter products such as throat lozenges, cough syrups, and topical pain relievers. It is important to note that eucalyptus oil should not be ingested undiluted, as it can be toxic in large amounts.

In addition to its medicinal uses, eucalyptus trees are also known for their rapid growth and ability to drain swampland, making them useful in land reclamation projects.

Regression analysis is a statistical technique used in medicine, as well as in other fields, to examine the relationship between one or more independent variables (predictors) and a dependent variable (outcome). It allows for the estimation of the average change in the outcome variable associated with a one-unit change in an independent variable, while controlling for the effects of other independent variables. This technique is often used to identify risk factors for diseases or to evaluate the effectiveness of medical interventions. In medical research, regression analysis can be used to adjust for potential confounding variables and to quantify the relationship between exposures and health outcomes. It can also be used in predictive modeling to estimate the probability of a particular outcome based on multiple predictors.

A homozygote is an individual who has inherited the same allele (version of a gene) from both parents and therefore possesses two identical copies of that allele at a specific genetic locus. This can result in either having two dominant alleles (homozygous dominant) or two recessive alleles (homozygous recessive). In contrast, a heterozygote has inherited different alleles from each parent for a particular gene.

The term "homozygote" is used in genetics to describe the genetic makeup of an individual at a specific locus on their chromosomes. Homozygosity can play a significant role in determining an individual's phenotype (observable traits), as having two identical alleles can strengthen the expression of certain characteristics compared to having just one dominant and one recessive allele.

Expressed Sequence Tags (ESTs) are short, single-pass DNA sequences that are derived from cDNA libraries. They represent a quick and cost-effective method for large-scale sequencing of gene transcripts and provide an unbiased view of the genes being actively expressed in a particular tissue or developmental stage. ESTs can be used to identify and study new genes, to analyze patterns of gene expression, and to develop molecular markers for genetic mapping and genome analysis.

A base sequence in the context of molecular biology refers to the specific order of nucleotides in a DNA or RNA molecule. In DNA, these nucleotides are adenine (A), guanine (G), cytosine (C), and thymine (T). In RNA, uracil (U) takes the place of thymine. The base sequence contains genetic information that is transcribed into RNA and ultimately translated into proteins. It is the exact order of these bases that determines the genetic code and thus the function of the DNA or RNA molecule.

Computational biology is a branch of biology that uses mathematical and computational methods to study biological data, models, and processes. It involves the development and application of algorithms, statistical models, and computational approaches to analyze and interpret large-scale molecular and phenotypic data from genomics, transcriptomics, proteomics, metabolomics, and other high-throughput technologies. The goal is to gain insights into biological systems and processes, develop predictive models, and inform experimental design and hypothesis testing in the life sciences. Computational biology encompasses a wide range of disciplines, including bioinformatics, systems biology, computational genomics, network biology, and mathematical modeling of biological systems.

Least-Squares Analysis is not a medical term, but rather a statistical method that is used in various fields including medicine. It is a way to find the best fit line or curve for a set of data points by minimizing the sum of the squared distances between the observed data points and the fitted line or curve. This method is often used in medical research to analyze data, such as fitting a regression line to a set of data points to make predictions or identify trends. The goal is to find the line or curve that most closely represents the pattern of the data, which can help researchers understand relationships between variables and make more informed decisions based on their analysis.

Oligonucleotide Array Sequence Analysis is a type of microarray analysis that allows for the simultaneous measurement of the expression levels of thousands of genes in a single sample. In this technique, oligonucleotides (short DNA sequences) are attached to a solid support, such as a glass slide, in a specific pattern. These oligonucleotides are designed to be complementary to specific target mRNA sequences from the sample being analyzed.

During the analysis, labeled RNA or cDNA from the sample is hybridized to the oligonucleotide array. The level of hybridization is then measured and used to determine the relative abundance of each target sequence in the sample. This information can be used to identify differences in gene expression between samples, which can help researchers understand the underlying biological processes involved in various diseases or developmental stages.

It's important to note that this technique requires specialized equipment and bioinformatics tools for data analysis, as well as careful experimental design and validation to ensure accurate and reproducible results.

Reproduction, in the context of biology and medicine, refers to the process by which organisms produce offspring. It is a complex process that involves the creation, development, and growth of new individuals from parent organisms. In sexual reproduction, this process typically involves the combination of genetic material from two parents through the fusion of gametes (sex cells) such as sperm and egg cells. This results in the formation of a zygote, which then develops into a new individual with a unique genetic makeup.

In contrast, asexual reproduction does not involve the fusion of gametes and can occur through various mechanisms such as budding, fragmentation, or parthenogenesis. Asexual reproduction results in offspring that are genetically identical to the parent organism.

Reproduction is a fundamental process that ensures the survival and continuation of species over time. It is also an area of active research in fields such as reproductive medicine, where scientists and clinicians work to understand and address issues related to human fertility, contraception, and genetic disorders.

"Body size" is a general term that refers to the overall physical dimensions and proportions of an individual's body. It can encompass various measurements, including height, weight, waist circumference, hip circumference, blood pressure, and other anthropometric measures.

In medical and public health contexts, body size is often used to assess health status, risk factors for chronic diseases, and overall well-being. For example, a high body mass index (BMI) may indicate excess body fat and increase the risk of conditions such as diabetes, hypertension, and cardiovascular disease. Similarly, a large waist circumference or high blood pressure may also be indicators of increased health risks.

It's important to note that body size is just one aspect of health and should not be used as the sole indicator of an individual's overall well-being. A holistic approach to health that considers multiple factors, including diet, physical activity, mental health, and social determinants of health, is essential for promoting optimal health outcomes.

I'm sorry for any confusion, but "soybeans" are not a medical term. They are a type of legume that is commonly used in agriculture and food production. The medical community might discuss soybeans in the context of nutrition or allergies, but there isn't a formal medical definition for this term.

Here's some general information: Soybeans, scientifically known as Glycine max, are native to East Asia and are now grown worldwide. They are a significant source of plant-based protein and oil. Soybeans contain various nutrients, including essential amino acids, fiber, B vitamins, and minerals like calcium, iron, magnesium, and zinc. They are used in various food products such as tofu, soy milk, tempeh, and miso. Additionally, soybeans are also used in the production of industrial products, including biodiesel, plastics, and inks. Some people may have allergic reactions to soybeans or soy products.

Restriction Fragment Length Polymorphism (RFLP) is a term used in molecular biology and genetics. It refers to the presence of variations in DNA sequences among individuals, which can be detected by restriction enzymes. These enzymes cut DNA at specific sites, creating fragments of different lengths.

In RFLP analysis, DNA is isolated from an individual and treated with a specific restriction enzyme that cuts the DNA at particular recognition sites. The resulting fragments are then separated by size using gel electrophoresis, creating a pattern unique to that individual's DNA. If there are variations in the DNA sequence between individuals, the restriction enzyme may cut the DNA at different sites, leading to differences in the length of the fragments and thus, a different pattern on the gel.

These variations can be used for various purposes, such as identifying individuals, diagnosing genetic diseases, or studying evolutionary relationships between species. However, RFLP analysis has largely been replaced by more modern techniques like polymerase chain reaction (PCR)-based methods and DNA sequencing, which offer higher resolution and throughput.

A mutation is a permanent change in the DNA sequence of an organism's genome. Mutations can occur spontaneously or be caused by environmental factors such as exposure to radiation, chemicals, or viruses. They may have various effects on the organism, ranging from benign to harmful, depending on where they occur and whether they alter the function of essential proteins. In some cases, mutations can increase an individual's susceptibility to certain diseases or disorders, while in others, they may confer a survival advantage. Mutations are the driving force behind evolution, as they introduce new genetic variability into populations, which can then be acted upon by natural selection.

Ascomycota is a phylum in the kingdom Fungi, also known as sac fungi. This group includes both unicellular and multicellular organisms, such as yeasts, mold species, and morel mushrooms. Ascomycetes are characterized by their reproductive structures called ascus, which contain typically eight haploid spores produced sexually through a process called ascogony. Some members of this phylum have significant ecological and economic importance, as they can be decomposers, mutualistic symbionts, or plant pathogens causing various diseases. Examples include the baker's yeast Saccharomyces cerevisiae, ergot fungus Claviceps purpurea, and morel mushroom Morchella esculenta.

Biological evolution is the change in the genetic composition of populations of organisms over time, from one generation to the next. It is a process that results in descendants differing genetically from their ancestors. Biological evolution can be driven by several mechanisms, including natural selection, genetic drift, gene flow, and mutation. These processes can lead to changes in the frequency of alleles (variants of a gene) within populations, resulting in the development of new species and the extinction of others over long periods of time. Biological evolution provides a unifying explanation for the diversity of life on Earth and is supported by extensive evidence from many different fields of science, including genetics, paleontology, comparative anatomy, and biogeography.

"Plant proteins" refer to the proteins that are derived from plant sources. These can include proteins from legumes such as beans, lentils, and peas, as well as proteins from grains like wheat, rice, and corn. Other sources of plant proteins include nuts, seeds, and vegetables.

Plant proteins are made up of individual amino acids, which are the building blocks of protein. While animal-based proteins typically contain all of the essential amino acids that the body needs to function properly, many plant-based proteins may be lacking in one or more of these essential amino acids. However, by consuming a variety of plant-based foods throughout the day, it is possible to get all of the essential amino acids that the body needs from plant sources alone.

Plant proteins are often lower in calories and saturated fat than animal proteins, making them a popular choice for those following a vegetarian or vegan diet, as well as those looking to maintain a healthy weight or reduce their risk of chronic diseases such as heart disease and cancer. Additionally, plant proteins have been shown to have a number of health benefits, including improving gut health, reducing inflammation, and supporting muscle growth and repair.

Behavioral genetics is a subfield of genetics that focuses on the study of the genetic basis of behavior. It seeks to understand how genes and environment interact to influence individual differences in behaviors such as personality traits, cognitive abilities, psychiatric disorders, and addiction. This field integrates knowledge from genetics, psychology, neuroscience, and statistics to investigate the complex relationship between genetic factors and behavioral outcomes. Research in behavioral genetics includes studies of twins, families, and adopted individuals, as well as animal models, to identify specific genes or genetic variations that contribute to the heritability of various behaviors. Understanding these genetic influences can provide insights into the prevention, diagnosis, and treatment of behavioral disorders.

I'm sorry for any confusion, but "Pennisetum" is not a medical term. It is the name of a genus of plants in the grass family, also known as fountain grasses or feather grasses. They are often used in ornamental landscaping. If you have any questions about a medical term or concept, I'd be happy to help clarify!

Genomic imprinting is a epigenetic process that leads to the differential expression of genes depending on their parental origin. It involves the methylation of certain CpG sites in the DNA, which results in the silencing of one of the two copies of a gene, either the maternal or paternal allele. This means that only one copy of the gene is active and expressed, while the other is silent.

This phenomenon is critical for normal development and growth, and it plays a role in the regulation of genes involved in growth and behavior. Genomic imprinting is also associated with certain genetic disorders, such as Prader-Willi and Angelman syndromes, which occur when there are errors in the imprinting process that lead to the absence or abnormal expression of certain genes.

It's important to note that genomic imprinting is a complex and highly regulated process that is not yet fully understood. Research in this area continues to provide new insights into the mechanisms underlying gene regulation and their impact on human health and disease.

I'm sorry for any confusion, but "Helianthus" is not a medical term. It is the genus name for sunflowers in the family Asteraceae. Sunflowers are native to North America and are known for their large, daisy-like flowers and tall stems. They have various uses, including ornamental purposes, food (seeds and oil), and medicinal applications in some traditional systems of medicine. However, there isn't a widely accepted medical definition associated with the term "Helianthus."

Chromosomes are thread-like structures that contain genetic material, i.e., DNA and proteins, present in the nucleus of human cells. In humans, there are 23 pairs of chromosomes, for a total of 46 chromosomes, in each diploid cell. Twenty-two of these pairs are called autosomal chromosomes, which come in identical pairs and contain genes that determine various traits unrelated to sex.

The last pair is referred to as the sex chromosomes (X and Y), which determines a person's biological sex. Females have two X chromosomes (46, XX), while males possess one X and one Y chromosome (46, XY). Chromosomes vary in size, with the largest being chromosome 1 and the smallest being the Y chromosome.

Human chromosomes are typically visualized during mitosis or meiosis using staining techniques that highlight their banding patterns, allowing for identification of specific regions and genes. Chromosomal abnormalities can lead to various genetic disorders, including Down syndrome (trisomy 21), Turner syndrome (monosomy X), and Klinefelter syndrome (XXY).

SHR (Spontaneously Hypertensive Rats) are an inbred strain of rats that were originally developed through selective breeding for high blood pressure. They are widely used as a model to study hypertension and related cardiovascular diseases, as well as neurological disorders such as stroke and dementia.

Inbred strains of animals are created by mating genetically identical individuals (siblings or offspring) for many generations, resulting in a population that is highly homozygous at all genetic loci. This means that the animals within an inbred strain are essentially genetically identical to one another, which makes them useful for studying the effects of specific genes or environmental factors on disease processes.

SHR rats develop high blood pressure spontaneously, without any experimental manipulation, and show many features of human hypertension, such as increased vascular resistance, left ventricular hypertrophy, and renal dysfunction. They also exhibit a number of behavioral abnormalities, including hyperactivity, impulsivity, and cognitive deficits, which make them useful for studying the neurological consequences of hypertension and other cardiovascular diseases.

Overall, inbred SHR rats are an important tool in biomedical research, providing a valuable model for understanding the genetic and environmental factors that contribute to hypertension and related disorders.

"Sex characteristics" refer to the anatomical, chromosomal, and genetic features that define males and females. These include both primary sex characteristics (such as reproductive organs like ovaries or testes) and secondary sex characteristics (such as breasts or facial hair) that typically develop during puberty. Sex characteristics are primarily determined by the presence of either X or Y chromosomes, with XX individuals usually developing as females and XY individuals usually developing as males, although variations and exceptions to this rule do occur.

Osteochondrosis is a group of orthopedic disorders that primarily affect the epiphyseal growth plates (the areas of growing tissue at the ends of long bones) and adjacent articular (joint) cartilage in children and adolescents. These disorders are characterized by abnormal development, degeneration, or fragmentation of the affected bone and/or cartilage, which can lead to pain, stiffness, and, in some cases, restricted mobility.

The term "osteochondrosis" is often used interchangeably with "osteochondritis dissecans," but they are not identical conditions. Osteochondrosis refers to the general category of disorders, while osteochondritis dissecans is a specific type of osteochondrosis that primarily affects the subchondral bone (the layer of bone directly beneath the articular cartilage) and results in the formation of loose fragments or "joint mice."

Examples of osteochondrosis include:

1. Legg-Calvé-Perthes disease, which affects the hip joint
2. Köhler's disease, which affects the navicular bone in the foot
3. Panner's disease, which affects the elbow joint
4. Scheuermann's disease, which affects the vertebral bodies in the spine
5. Freiberg's infarction, which affects the metatarsal heads in the foot

The exact cause of osteochondrosis remains unclear, but it is believed to involve a combination of genetic, biomechanical, and environmental factors that contribute to the abnormal growth and development of the affected bone and cartilage. Treatment typically involves rest, physical therapy, bracing or casting, and, in some cases, surgery to remove loose fragments or promote healing.

Genotyping techniques are a group of laboratory methods used to identify and detect specific variations or differences in the DNA sequence, known as genetic variants or polymorphisms, that make up an individual's genotype. These techniques can be applied to various fields, including medical diagnostics, forensic science, and genetic research.

There are several types of genotyping techniques, each with its advantages and limitations depending on the application. Some common methods include:

1. Polymerase Chain Reaction (PCR)-based methods: These involve amplifying specific DNA sequences using PCR and then analyzing them for genetic variations. Examples include Restriction Fragment Length Polymorphism (RFLP), Amplification Refractory Mutation System (ARMS), and Allele-Specific PCR (AS-PCR).
2. Microarray-based methods: These involve hybridizing DNA samples to arrays containing thousands of known genetic markers or probes, allowing for simultaneous detection of multiple genetic variants. Examples include Single Nucleotide Polymorphism (SNP) arrays and Comparative Genomic Hybridization (CGH) arrays.
3. Sequencing-based methods: These involve determining the precise order of nucleotides in a DNA sequence to identify genetic variations. Examples include Sanger sequencing, Next-Generation Sequencing (NGS), and Whole Genome Sequencing (WGS).
4. Mass spectrometry-based methods: These involve measuring the mass-to-charge ratio of DNA fragments or oligonucleotides to identify genetic variants. Examples include Matrix-Assisted Laser Desorption/Ionization Time-of-Flight (MALDI-TOF) mass spectrometry and Pyrosequencing.

Genotyping techniques have numerous applications in medicine, such as identifying genetic susceptibility to diseases, predicting drug response, and diagnosing genetic disorders. They also play a crucial role in forensic science for identifying individuals and solving crimes.

WKY (Wistar Kyoto) is not a term that refers to "rats, inbred" in a medical definition. Instead, it is a strain of laboratory rat that is widely used in biomedical research. WKY rats are an inbred strain, which means they are the result of many generations of brother-sister matings, resulting in a genetically uniform population.

WKY rats originated from the Wistar Institute in Philadelphia and were established as a normotensive control strain to contrast with other rat strains that exhibit hypertension. They have since been used in various research areas, including cardiovascular, neurological, and behavioral studies. Compared to other commonly used rat strains like the spontaneously hypertensive rat (SHR), WKY rats are known for their lower blood pressure, reduced stress response, and greater emotionality.

In summary, "WKY" is a designation for an inbred strain of laboratory rat that is often used as a control group in biomedical research due to its normotensive characteristics.

I'm sorry for any confusion, but "fruit" is not a medical term per se. It is a common term used to describe the part of a plant that develops from the ovary after flowering and contains seeds. However, in a nutritional or dietary context, "fruits" are often referred to as foods that are typically sweet and juicy, and come from plants' flowers. They are rich in fiber, vitamins, and minerals, making them an essential part of a healthy diet. But in a strict medical sense, there isn't a specific definition for "fruit."

Organ size refers to the volume or physical measurement of an organ in the body of an individual. It can be described in terms of length, width, and height or by using specialized techniques such as imaging studies (like CT scans or MRIs) to determine the volume. The size of an organ can vary depending on factors such as age, sex, body size, and overall health status. Changes in organ size may indicate various medical conditions, including growths, inflammation, or atrophy.

Medically, "milk" is not defined. However, it is important to note that human babies are fed with breast milk, which is the secretion from the mammary glands of humans. It is rich in nutrients like proteins, fats, carbohydrates (lactose), vitamins and minerals that are essential for growth and development.

Other mammals also produce milk to feed their young. These include cows, goats, and sheep, among others. Their milk is often consumed by humans as a source of nutrition, especially in dairy products. However, the composition of these milks can vary significantly from human breast milk.

The X chromosome is one of the two types of sex-determining chromosomes in humans (the other being the Y chromosome). It's one of the 23 pairs of chromosomes that make up a person's genetic material. Females typically have two copies of the X chromosome (XX), while males usually have one X and one Y chromosome (XY).

The X chromosome contains hundreds of genes that are responsible for the production of various proteins, many of which are essential for normal bodily functions. Some of the critical roles of the X chromosome include:

1. Sex Determination: The presence or absence of the Y chromosome determines whether an individual is male or female. If there is no Y chromosome, the individual will typically develop as a female.
2. Genetic Disorders: Since females have two copies of the X chromosome, they are less likely to be affected by X-linked genetic disorders than males. Males, having only one X chromosome, will express any recessive X-linked traits they inherit.
3. Dosage Compensation: To compensate for the difference in gene dosage between males and females, a process called X-inactivation occurs during female embryonic development. One of the two X chromosomes is randomly inactivated in each cell, resulting in a single functional copy per cell.

The X chromosome plays a crucial role in human genetics and development, contributing to various traits and characteristics, including sex determination and dosage compensation.

I'm sorry for any confusion, but "Linear Models" is actually a term from the field of statistics and machine learning, rather than medicine. A linear model is a type of statistical model that is used to analyze the relationship between two or more variables. In a linear model, the relationship between the dependent variable (the outcome or result) and the independent variable(s) (the factors being studied) is assumed to be linear, meaning that it can be described by a straight line on a graph.

The equation for a simple linear model with one independent variable (x) and one dependent variable (y) looks like this:

y = β0 + β1*x + ε

In this equation, β0 is the y-intercept or the value of y when x equals zero, β1 is the slope or the change in y for each unit increase in x, and ε is the error term or the difference between the actual values of y and the predicted values of y based on the linear model.

Linear models are widely used in medical research to study the relationship between various factors (such as exposure to a risk factor or treatment) and health outcomes (such as disease incidence or mortality). They can also be used to adjust for confounding variables, which are factors that may influence both the independent variable and the dependent variable, and thus affect the observed relationship between them.

In medical statistics, a statistical distribution refers to the pattern of frequency or proportion of certain variables in a population. It describes how the data points in a sample are distributed and can be used to make inferences about a larger population. There are various types of statistical distributions, including normal (or Gaussian) distribution, binomial distribution, Poisson distribution, and exponential distribution, among others. These distributions have specific mathematical properties that allow researchers to calculate probabilities and make predictions based on the data. For example, a normal distribution is characterized by its mean and standard deviation, while a Poisson distribution models the number of events occurring within a fixed interval of time or space. Understanding statistical distributions is crucial for interpreting medical research findings and making informed decisions in healthcare.

'Drosophila melanogaster' is the scientific name for a species of fruit fly that is commonly used as a model organism in various fields of biological research, including genetics, developmental biology, and evolutionary biology. Its small size, short generation time, large number of offspring, and ease of cultivation make it an ideal subject for laboratory studies. The fruit fly's genome has been fully sequenced, and many of its genes have counterparts in the human genome, which facilitates the understanding of genetic mechanisms and their role in human health and disease.

Here is a brief medical definition:

Drosophila melanogaster (droh-suh-fih-luh meh-lon-guh-ster): A species of fruit fly used extensively as a model organism in genetic, developmental, and evolutionary research. Its genome has been sequenced, revealing many genes with human counterparts, making it valuable for understanding genetic mechanisms and their role in human health and disease.

'Gene expression regulation' refers to the processes that control whether, when, and where a particular gene is expressed, meaning the production of a specific protein or functional RNA encoded by that gene. This complex mechanism can be influenced by various factors such as transcription factors, chromatin remodeling, DNA methylation, non-coding RNAs, and post-transcriptional modifications, among others. Proper regulation of gene expression is crucial for normal cellular function, development, and maintaining homeostasis in living organisms. Dysregulation of gene expression can lead to various diseases, including cancer and genetic disorders.

I'm sorry for any confusion, but "siblings" is not a medical term. It is a term used in genealogy and sociology to refer to the brothers and sisters that someone has. Sibling relationships can have medical implications, such as when inherited genetic disorders are present in a family, but the term "siblings" itself does not have a specific medical definition.

Amplified Fragment Length Polymorphism (AFLP) analysis is a molecular biology technique used for DNA fingerprinting, genetic mapping, and population genetics studies. It is based on the selective amplification of restriction fragments from a total digest of genomic DNA, followed by separation and detection of the resulting fragments using polyacrylamide gel electrophoresis.

In AFLP analysis, genomic DNA is first digested with two different restriction enzymes, one that cuts frequently (e.g., EcoRI) and another that cuts less frequently (e.g., MseI). The resulting fragments are then ligated to adapter sequences that provide recognition sites for PCR amplification.

Selective amplification of the restriction fragments is achieved by using primers that anneal to the adapter sequences and contain additional selective nucleotides at their 3' ends. This allows for the amplification of a subset of the total number of restriction fragments, resulting in a pattern of bands that is specific to the DNA sample being analyzed.

The amplified fragments are then separated by size using polyacrylamide gel electrophoresis and visualized by staining with a fluorescent dye. The resulting banding pattern can be used for various applications, including identification of genetic differences between individuals, detection of genomic alterations in cancer cells, and analysis of population structure and diversity.

Overall, AFLP analysis is a powerful tool for the study of complex genomes and has been widely used in various fields of biology, including plant and animal breeding, forensic science, and medical research.

In the context of medical terminology, "germination" is not typically used as a term to describe a physiological process in humans or animals. It is primarily used in the field of botany to refer to the process by which a seed or spore sprouts and begins to grow into a new plant.

However, if you are referring to the concept of germination in the context of bacterial or viral growth, then it could be defined as:

The process by which bacteria, viruses, or other microorganisms become active and start to multiply, often after a period of dormancy or latency. This can occur when the microorganisms encounter favorable conditions, such as moisture, warmth, or nutrients, that allow them to grow and reproduce. In medical contexts, this term is more commonly used in relation to infectious diseases caused by these microorganisms.

Innate immunity, also known as non-specific immunity or natural immunity, is the inherent defense mechanism that provides immediate protection against potentially harmful pathogens (like bacteria, viruses, fungi, and parasites) without the need for prior exposure. This type of immunity is present from birth and does not adapt to specific threats over time.

Innate immune responses involve various mechanisms such as:

1. Physical barriers: Skin and mucous membranes prevent pathogens from entering the body.
2. Chemical barriers: Enzymes, stomach acid, and lysozyme in tears, saliva, and sweat help to destroy or inhibit the growth of microorganisms.
3. Cellular responses: Phagocytic cells (neutrophils, monocytes, macrophages) recognize and engulf foreign particles and pathogens, while natural killer (NK) cells target and eliminate virus-infected or cancerous cells.
4. Inflammatory response: When an infection occurs, the innate immune system triggers inflammation to increase blood flow, recruit immune cells, and remove damaged tissue.
5. Complement system: A group of proteins that work together to recognize and destroy pathogens directly or enhance phagocytosis by coating them with complement components (opsonization).

Innate immunity plays a crucial role in initiating the adaptive immune response, which is specific to particular pathogens and provides long-term protection through memory cells. Both innate and adaptive immunity work together to maintain overall immune homeostasis and protect the body from infections and diseases.

Penetrance, in medical genetics, refers to the proportion of individuals with a particular genetic variant or mutation who exhibit clinical features or symptoms of a resulting disease. It is often expressed as a percentage, with complete penetrance indicating that all individuals with the genetic change will develop the disease, and reduced or incomplete penetrance suggesting that not all individuals with the genetic change will necessarily develop the disease, even if they express some of its characteristics.

Penetrance can vary depending on various factors such as age, sex, environmental influences, and interactions with other genes. Incomplete penetrance is common in many genetic disorders, making it challenging to predict who will develop symptoms based solely on their genotype.

Gene-Environment Interaction (GEI) is a concept in genetics that refers to the way in which genetic variations and environmental factors interact to influence traits or disease susceptibility. It describes a situation where the effect of an environmental exposure on a particular trait or disease outcome is dependent on the genetic makeup of the individual, and vice versa.

In other words, GEI suggests that the impact of environmental factors on health outcomes may be different depending on a person's genetic background, and similarly, the influence of certain genes on health outcomes may depend on the presence or absence of specific environmental exposures. This interaction can help explain why some individuals are more susceptible to certain diseases or traits than others, even when exposed to similar environments.

GEI is an important concept in precision medicine, as understanding these interactions can help identify individuals who are at higher risk for certain diseases and develop targeted prevention and treatment strategies based on their genetic and environmental profiles.

Pigmentation, in a medical context, refers to the coloring of the skin, hair, or eyes due to the presence of pigment-producing cells called melanocytes. These cells produce a pigment called melanin, which determines the color of our skin, hair, and eyes.

There are two main types of melanin: eumelanin and pheomelanin. Eumelanin is responsible for brown or black coloration, while pheomelanin produces a red or yellow hue. The amount and type of melanin produced by melanocytes can vary from person to person, leading to differences in skin color and hair color.

Changes in pigmentation can occur due to various factors such as genetics, exposure to sunlight, hormonal changes, inflammation, or certain medical conditions. For example, hyperpigmentation refers to an excess production of melanin that results in darkened patches on the skin, while hypopigmentation is a condition where there is a decreased production of melanin leading to lighter or white patches on the skin.

'Solanum melongena' is the scientific name for a plant species more commonly known as eggplant or aubergine. It belongs to the Solanaceae family, which also includes tomatoes, bell peppers, and potatoes. The eggplant fruit is widely consumed and used in various cuisines around the world.

While 'Solanum melongena' is a horticultural term related to the plant species, it does not have a direct medical definition. However, eggplants do have some nutritional and potential medicinal properties. They are low in calories and contain vitamins, minerals, and dietary fiber. Some studies suggest that eggplants may have antioxidant and anti-inflammatory properties due to their phenolic compounds. Nonetheless, it is essential to consult medical professionals or healthcare providers for advice on medicinal applications rather than relying on information about the plant's scientific name alone.

Human chromosome pair 5 consists of two rod-shaped structures present in the nucleus of human cells, which contain genetic material in the form of DNA and proteins. Each member of chromosome pair 5 is a single chromosome, and humans typically have 23 pairs of chromosomes for a total of 46 chromosomes in every cell of their body (except gametes or sex cells, which contain 23 chromosomes).

Chromosome pair 5 is one of the autosomal pairs, meaning it is not a sex chromosome. Each member of chromosome pair 5 is approximately 197 million base pairs in length and contains around 800-900 genes that provide instructions for making proteins and regulating various cellular processes.

Chromosome pair 5 is associated with several genetic disorders, including cri du chat syndrome (resulting from a deletion on the short arm of chromosome 5), Prader-Willi syndrome and Angelman syndrome (both resulting from abnormalities in gene expression on the long arm of chromosome 5).

In the context of public health and epidemiology, a population refers to a group of individuals who share common characteristics or are defined by specific boundaries and parameters. These parameters can include geographical location, age range, sex, race, ethnicity, exposure to certain risk factors, or shared health status.

The health status and trends of a population are often studied through surveillance and research to understand the determinants of health, disease patterns, and health disparities within the group. This information is then used to inform public health policies, interventions, and programs aimed at improving the overall health and well-being of the population.

"Pinus taeda," also known as Loblolly Pine, is not a medical term. It is a species of tree in the family Pinaceae that is native to the southeastern United States. The tree is commonly used in the production of timber, paper, and pulp, and it has some medicinal uses as well.

The bark, leaves (needles), and sap of the Loblolly Pine have been used traditionally by indigenous peoples for various medicinal purposes, such as treating skin conditions, wounds, and respiratory ailments. However, there is limited scientific evidence to support these uses, and they should not be attempted without consulting a healthcare professional.

I'm sorry for any confusion, but "seedling" is not a term that has a specific medical definition. It is an agricultural and horticultural term that refers to a young plant grown from a seed, typically during the early stages of its growth. If you have any questions related to health or medicine, I'd be happy to try to help with those!

Artificial bacterial chromosomes (ABCs) are synthetic replicons that are designed to function like natural bacterial chromosomes. They are created through the use of molecular biology techniques, such as recombination and cloning, to construct large DNA molecules that can stably replicate and segregate within a host bacterium.

ABCs are typically much larger than traditional plasmids, which are smaller circular DNA molecules that can also replicate in bacteria but have a limited capacity for carrying genetic information. ABCs can accommodate large DNA inserts, making them useful tools for cloning and studying large genes, gene clusters, or even entire genomes of other organisms.

There are several types of ABCs, including bacterial artificial chromosomes (BACs), P1-derived artificial chromosomes (PACs), and yeast artificial chromosomes (YACs). BACs are the most commonly used type of ABC and can accommodate inserts up to 300 kilobases (kb) in size. They have been widely used in genome sequencing projects, functional genomics studies, and protein production.

Overall, artificial bacterial chromosomes provide a powerful tool for manipulating and studying large DNA molecules in a controlled and stable manner within bacterial hosts.

Genetically modified plants (GMPs) are plants that have had their DNA altered through genetic engineering techniques to exhibit desired traits. These modifications can be made to enhance certain characteristics such as increased resistance to pests, improved tolerance to environmental stresses like drought or salinity, or enhanced nutritional content. The process often involves introducing genes from other organisms, such as bacteria or viruses, into the plant's genome. Examples of GMPs include Bt cotton, which has a gene from the bacterium Bacillus thuringiensis that makes it resistant to certain pests, and golden rice, which is engineered to contain higher levels of beta-carotene, a precursor to vitamin A. It's important to note that genetically modified plants are subject to rigorous testing and regulation to ensure their safety for human consumption and environmental impact before they are approved for commercial use.

A medical definition for "plant shoots" may not be readily available, as the term is primarily used in botany and horticulture. However, I can provide you with a general definition:

Plant shoots refer to the above-ground portion of a plant, which typically includes structures like stems, leaves, flowers, and buds. Shoots originate from the seed or the growing tip of the plant and are responsible for photosynthesis, nutrient absorption, and reproduction. In some contexts, "plant shoots" might also refer to new growth that emerges from an existing plant, such as when a leaf or stem sprouts a new branch or flower.

Human chromosome pair 6 consists of two rod-shaped structures present in the nucleus of each human cell. They are identical in size and shape and contain genetic material, made up of DNA and proteins, that is essential for the development and function of the human body.

Chromosome pair 6 is one of the 23 pairs of chromosomes found in humans, with one chromosome inherited from each parent. Each chromosome contains thousands of genes that provide instructions for the production of proteins and regulate various cellular processes.

Chromosome pair 6 contains several important genes, including those involved in the development and function of the immune system, such as the major histocompatibility complex (MHC) genes. It also contains genes associated with certain genetic disorders, such as hereditary neuropathy with liability to pressure palsies (HNPP), a condition that affects the nerves, and Waardenburg syndrome, a disorder that affects pigmentation and hearing.

Abnormalities in chromosome pair 6 can lead to various genetic disorders, including numerical abnormalities such as trisomy 6 (three copies of chromosome 6) or monosomy 6 (only one copy of chromosome 6), as well as structural abnormalities such as deletions, duplications, or translocations of parts of the chromosome.

Animal disease models are specialized animals, typically rodents such as mice or rats, that have been genetically engineered or exposed to certain conditions to develop symptoms and physiological changes similar to those seen in human diseases. These models are used in medical research to study the pathophysiology of diseases, identify potential therapeutic targets, test drug efficacy and safety, and understand disease mechanisms.

The genetic modifications can include knockout or knock-in mutations, transgenic expression of specific genes, or RNA interference techniques. The animals may also be exposed to environmental factors such as chemicals, radiation, or infectious agents to induce the disease state.

Examples of animal disease models include:

1. Mouse models of cancer: Genetically engineered mice that develop various types of tumors, allowing researchers to study cancer initiation, progression, and metastasis.
2. Alzheimer's disease models: Transgenic mice expressing mutant human genes associated with Alzheimer's disease, which exhibit amyloid plaque formation and cognitive decline.
3. Diabetes models: Obese and diabetic mouse strains like the NOD (non-obese diabetic) or db/db mice, used to study the development of type 1 and type 2 diabetes, respectively.
4. Cardiovascular disease models: Atherosclerosis-prone mice, such as ApoE-deficient or LDLR-deficient mice, that develop plaque buildup in their arteries when fed a high-fat diet.
5. Inflammatory bowel disease models: Mice with genetic mutations affecting intestinal barrier function and immune response, such as IL-10 knockout or SAMP1/YitFc mice, which develop colitis.

Animal disease models are essential tools in preclinical research, but it is important to recognize their limitations. Differences between species can affect the translatability of results from animal studies to human patients. Therefore, researchers must carefully consider the choice of model and interpret findings cautiously when applying them to human diseases.

In the context of medicine, growth generally refers to the increase in size or mass of an organism or a specific part of the body over time. This can be quantified through various methods such as measuring height, weight, or the dimensions of particular organs or tissues. In children, normal growth is typically assessed using growth charts that plot measurements like height and weight against age to determine whether a child's growth is following a typical pattern.

Growth can be influenced by a variety of factors, including genetics, nutrition, hormonal regulation, and overall health status. Abnormalities in growth patterns may indicate underlying medical conditions or developmental disorders that require further evaluation and treatment.

A genetic complementation test is a laboratory procedure used in molecular genetics to determine whether two mutated genes can complement each other's function, indicating that they are located at different loci and represent separate alleles. This test involves introducing a normal or wild-type copy of one gene into a cell containing a mutant version of the same gene, and then observing whether the presence of the normal gene restores the normal function of the mutated gene. If the introduction of the normal gene results in the restoration of the normal phenotype, it suggests that the two genes are located at different loci and can complement each other's function. However, if the introduction of the normal gene does not restore the normal phenotype, it suggests that the two genes are located at the same locus and represent different alleles of the same gene. This test is commonly used to map genes and identify genetic interactions in a variety of organisms, including bacteria, yeast, and animals.

Physiological adaptation refers to the changes or modifications that occur in an organism's biological functions or structures as a result of environmental pressures or changes. These adaptations enable the organism to survive and reproduce more successfully in its environment. They can be short-term, such as the constriction of blood vessels in response to cold temperatures, or long-term, such as the evolution of longer limbs in animals that live in open environments.

In the context of human physiology, examples of physiological adaptation include:

1. Acclimatization: The process by which the body adjusts to changes in environmental conditions, such as altitude or temperature. For example, when a person moves to a high-altitude location, their body may produce more red blood cells to compensate for the lower oxygen levels, leading to improved oxygen delivery to tissues.

2. Exercise adaptation: Regular physical activity can lead to various physiological adaptations, such as increased muscle strength and endurance, enhanced cardiovascular function, and improved insulin sensitivity.

3. Hormonal adaptation: The body can adjust hormone levels in response to changes in the environment or internal conditions. For instance, during prolonged fasting, the body releases stress hormones like cortisol and adrenaline to help maintain energy levels and prevent muscle wasting.

4. Sensory adaptation: Our senses can adapt to different stimuli over time. For example, when we enter a dark room after being in bright sunlight, it takes some time for our eyes to adjust to the new light level. This process is known as dark adaptation.

5. Aging-related adaptations: As we age, various physiological changes occur that help us adapt to the changing environment and maintain homeostasis. These include changes in body composition, immune function, and cognitive abilities.

Human chromosome pair 7 consists of two rod-shaped structures present in the nucleus of each cell in the human body. Each member of the pair is a single chromosome, and together they contain the genetic material that is inherited from both parents. They are identical in size, shape, and banding pattern and are therefore referred to as homologous chromosomes.

Chromosome 7 is one of the autosomal chromosomes, meaning it is not a sex chromosome (X or Y). It is composed of double-stranded DNA that contains approximately 159 million base pairs and around 1,200 genes. Chromosome 7 contains several important genes associated with human health and disease, including those involved in the development of certain types of cancer, such as colon cancer and lung cancer, as well as genetic disorders such as Williams-Beuren syndrome and Charcot-Marie-Tooth disease.

Abnormalities in chromosome 7 have been linked to various genetic conditions, including deletions, duplications, translocations, and other structural changes. These abnormalities can lead to developmental delays, intellectual disabilities, physical abnormalities, and increased risk of certain types of cancer.

Gene expression is the process by which the information encoded in a gene is used to synthesize a functional gene product, such as a protein or RNA molecule. This process involves several steps: transcription, RNA processing, and translation. During transcription, the genetic information in DNA is copied into a complementary RNA molecule, known as messenger RNA (mRNA). The mRNA then undergoes RNA processing, which includes adding a cap and tail to the mRNA and splicing out non-coding regions called introns. The resulting mature mRNA is then translated into a protein on ribosomes in the cytoplasm through the process of translation.

The regulation of gene expression is a complex and highly controlled process that allows cells to respond to changes in their environment, such as growth factors, hormones, and stress signals. This regulation can occur at various stages of gene expression, including transcriptional activation or repression, RNA processing, mRNA stability, and translation. Dysregulation of gene expression has been implicated in many diseases, including cancer, genetic disorders, and neurological conditions.

Phylogeny is the evolutionary history and relationship among biological entities, such as species or genes, based on their shared characteristics. In other words, it refers to the branching pattern of evolution that shows how various organisms have descended from a common ancestor over time. Phylogenetic analysis involves constructing a tree-like diagram called a phylogenetic tree, which depicts the inferred evolutionary relationships among organisms or genes based on molecular sequence data or other types of characters. This information is crucial for understanding the diversity and distribution of life on Earth, as well as for studying the emergence and spread of diseases.

Gene Regulatory Networks (GRNs) are complex systems of molecular interactions that regulate the expression of genes within an organism. These networks consist of various types of regulatory elements, including transcription factors, enhancers, promoters, and silencers, which work together to control when, where, and to what extent a gene is expressed.

In GRNs, transcription factors bind to specific DNA sequences in the regulatory regions of target genes, either activating or repressing their transcription into messenger RNA (mRNA). This process is influenced by various intracellular and extracellular signals that modulate the activity of transcription factors, allowing for precise regulation of gene expression in response to changing environmental conditions.

The structure and behavior of GRNs can be represented as a network of nodes (genes) and edges (regulatory interactions), with the strength and directionality of these interactions determined by the specific molecular mechanisms involved. Understanding the organization and dynamics of GRNs is crucial for elucidating the underlying causes of various biological processes, including development, differentiation, homeostasis, and disease.

Biometry, also known as biometrics, is the scientific study of measurements and statistical analysis of living organisms. In a medical context, biometry is often used to refer to the measurement and analysis of physical characteristics or features of the human body, such as height, weight, blood pressure, heart rate, and other physiological variables. These measurements can be used for a variety of purposes, including diagnosis, treatment planning, monitoring disease progression, and research.

In addition to physical measurements, biometry may also refer to the use of statistical methods to analyze biological data, such as genetic information or medical images. This type of analysis can help researchers and clinicians identify patterns and trends in large datasets, and make predictions about health outcomes or treatment responses.

Overall, biometry is an important tool in modern medicine, as it allows healthcare professionals to make more informed decisions based on data and evidence.

Genes in insects refer to the hereditary units of DNA that are passed down from parents to offspring and contain the instructions for the development, function, and reproduction of an organism. These genetic materials are located within the chromosomes in the nucleus of insect cells. They play a crucial role in determining various traits such as physical characteristics, behavior, and susceptibility to diseases.

Insect genes, like those of other organisms, consist of exons (coding regions) that contain information for protein synthesis and introns (non-coding regions) that are removed during the process of gene expression. The expression of insect genes is regulated by various factors such as transcription factors, enhancers, and silencers, which bind to specific DNA sequences to activate or repress gene transcription.

Understanding the genetic makeup of insects has important implications for various fields, including agriculture, public health, and evolutionary biology. For example, genes associated with insect pests' resistance to pesticides can be identified and targeted to develop more effective control strategies. Similarly, genes involved in disease transmission by insect vectors such as mosquitoes can be studied to develop novel interventions for preventing the spread of infectious diseases.

Blood pressure is the force exerted by circulating blood on the walls of the blood vessels. It is measured in millimeters of mercury (mmHg) and is given as two figures:

1. Systolic pressure: This is the pressure when the heart pushes blood out into the arteries.
2. Diastolic pressure: This is the pressure when the heart rests between beats, allowing it to fill with blood.

Normal blood pressure for adults is typically around 120/80 mmHg, although this can vary slightly depending on age, sex, and other factors. High blood pressure (hypertension) is generally considered to be a reading of 130/80 mmHg or higher, while low blood pressure (hypotension) is usually defined as a reading below 90/60 mmHg. It's important to note that blood pressure can fluctuate throughout the day and may be affected by factors such as stress, physical activity, and medication use.

Hypertension is a medical term used to describe abnormally high blood pressure in the arteries, often defined as consistently having systolic blood pressure (the top number in a blood pressure reading) over 130 mmHg and/or diastolic blood pressure (the bottom number) over 80 mmHg. It is also commonly referred to as high blood pressure.

Hypertension can be classified into two types: primary or essential hypertension, which has no identifiable cause and accounts for about 95% of cases, and secondary hypertension, which is caused by underlying medical conditions such as kidney disease, hormonal disorders, or use of certain medications.

If left untreated, hypertension can lead to serious health complications such as heart attack, stroke, heart failure, and chronic kidney disease. Therefore, it is important for individuals with hypertension to manage their condition through lifestyle modifications (such as healthy diet, regular exercise, stress management) and medication if necessary, under the guidance of a healthcare professional.

Inbred A mice are a strain of laboratory mice that have been produced by many generations of brother-sister matings. This results in a high degree of genetic similarity among individuals within the strain, making them useful for research purposes where a consistent genetic background is desired. The Inbred A strain is maintained through continued brother-sister mating. It's important to note that while these mice are called "Inbred A," the designation does not refer to any specific medical condition or characteristic. Instead, it refers to the breeding practices used to create and maintain this particular strain of laboratory mice.

A plant stem is not typically defined in a medical context, but rather in the field of botany. However, I can certainly provide a general biological definition for you.

In plants, stems are organs that serve primarily as support structures, holding leaves, flowers, and fruits aloft where they can receive sunlight and exchange gases. They also act as conduits, transporting water, nutrients, and sugars made during photosynthesis between the roots and shoots of a plant.

The stem is usually composed of three main tissue systems: dermal, vascular, and ground. The dermal tissue system forms the outermost layer(s) of the stem, providing protection and sometimes participating in gas exchange. The vascular tissue system contains the xylem (which transports water and nutrients upward) and phloem (which transports sugars and other organic compounds downward). The ground tissue system, located between the dermal and vascular tissues, is responsible for food storage and support.

While not a direct medical definition, understanding the structure and function of plant stems can be relevant in fields such as nutrition, agriculture, and environmental science, which have implications for human health.

Principal Component Analysis (PCA) is not a medical term, but a statistical technique that is used in various fields including bioinformatics and medicine. It is a method used to identify patterns in high-dimensional data by reducing the dimensionality of the data while retaining most of the variation in the dataset.

In medical or biological research, PCA may be used to analyze large datasets such as gene expression data or medical imaging data. By applying PCA, researchers can identify the principal components, which are linear combinations of the original variables that explain the maximum amount of variance in the data. These principal components can then be used for further analysis, visualization, and interpretation of the data.

PCA is a widely used technique in data analysis and has applications in various fields such as genomics, proteomics, metabolomics, and medical imaging. It helps researchers to identify patterns and relationships in complex datasets, which can lead to new insights and discoveries in medical research.

Human chromosome pair 4 consists of two rod-shaped structures present in the nucleus of each cell in the human body. Each member of the pair is a single chromosome, and they are identical or very similar in length and gene content. Chromosomes are made up of DNA, which contains genetic information, and proteins that package and organize the DNA.

Human chromosomes are numbered from 1 to 22, with chromosome pair 4 being one of the autosomal pairs, meaning it is not a sex chromosome (X or Y). Chromosome pair 4 is a medium-sized pair and contains an estimated 1,800-2,000 genes. These genes provide instructions for making proteins that are essential for various functions in the body, such as development, growth, and metabolism.

Abnormalities in chromosome pair 4 can lead to genetic disorders, including Wolf-Hirschhorn syndrome, which is caused by a deletion of part of the short arm of chromosome 4, and 4p16.3 microdeletion syndrome, which is caused by a deletion of a specific region on the short arm of chromosome 4. These conditions can result in developmental delays, intellectual disability, physical abnormalities, and other health problems.

"Plant immunity" refers to the complex defense mechanisms that plants have evolved to protect themselves from pathogens, such as bacteria, viruses, fungi, and nematodes. Plants do not have an adaptive immune system like humans, so they rely on their innate immune responses to detect and respond to pathogen invasion.

Plant immunity can be broadly categorized into two types: PTI (PAMP-triggered immunity) and ETI (Effector-triggered immunity). PTI is activated when the plant recognizes conserved microbial patterns, known as PAMPs (Pathogen-Associated Molecular Patterns), through pattern recognition receptors (PRRs) located on the cell surface. This recognition triggers a series of defense responses, such as the production of reactive oxygen species, the activation of mitogen-activated protein kinases (MAPKs), and the expression of defense genes.

ETI is activated when the plant recognizes effector proteins produced by pathogens to suppress PTI. Effector recognition typically occurs through resistance (R) proteins that can directly or indirectly recognize effectors, leading to the activation of stronger defense responses, such as the hypersensitive response (HR), which involves localized programmed cell death to limit pathogen spread.

Overall, plant immunity is a complex and dynamic process involving multiple layers of defense mechanisms that help plants protect themselves from pathogens and maintain their health and productivity.

I'm sorry for any confusion, but "hydroponics" is not a medical term. It is an agricultural technique and term. Hydroponics refers to the practice of growing plants in nutrient-rich water solutions, without soil. This method allows plants to obtain their necessary nutrients directly from the water, which is enriched with dissolved minerals. Common hydroponic systems include wick systems, deep water culture, nutrient film technique, ebb and flow system, aeroponics, and drip systems.

Cereals, in a medical context, are not specifically defined. However, cereals are generally understood to be grasses of the family Poaceae that are cultivated for the edible components of their grain (the seed of the grass). The term "cereal" is derived from Ceres, the Roman goddess of agriculture and harvest.

The most widely consumed cereals include:

1. Wheat
2. Rice
3. Corn (Maize)
4. Barley
5. Oats
6. Millet
7. Sorghum
8. Rye

Cereals are a significant part of the human diet, providing energy in the form of carbohydrates, as well as protein, fiber, vitamins, and minerals. They can be consumed in various forms, such as whole grains, flour, flakes, or puffed cereals. Some people may have allergies or intolerances to specific cereals, like celiac disease, an autoimmune disorder that requires a gluten-free diet (wheat, barley, and rye contain gluten).

... (eQTLs) are genomic loci that explain variation in expression levels of mRNAs. An expression ... Doss S, Schadt EE, Drake TA, Lusis AJ (May 2005). "Cis-acting expression quantitative trait loci in mice". Genome Research. 15 ... Michaelson JJ, Loguercio S, Beyer A (July 2009). "Detection and interpretation of expression quantitative trait loci (eQTL)". ... Epigenome-wide association study Quantitative trait locus (QTL) Transcriptome-wide association study Rockman MV, Kruglyak L ( ...
... (abbreviated sQTLs or splicing QTLs) are quantitative trait loci that regulate alternative ... v t e (Articles with short description, Short description matches Wikidata, Quantitative trait loci, All stub articles, ... Wu E, Nance T, Montgomery SB (April 2014). "SplicePlot: a utility for visualizing splicing quantitative trait loci". ... "Genome-wide identification of splicing QTLs in the human brain and their enrichment among schizophrenia-associated loci". ...
... (or rtQTL) are genetic variations that lead to a differential use of replication ...
A quantitative trait locus (QTL) is a locus (section of DNA) that correlates with variation of a quantitative trait in the ... Scitable Mapping Quantitative Trait Loci What are Quantitative Trait Loci? - University of Warwick (CS1 maint: archived copy as ... SNP data and analysis of quantitative traits Precision Mapping of Quantitative Trait Loci QTL Cartographer Complex Trait ... A quantitative trait locus (QTL) is a region of DNA which is associated with a particular phenotypic trait, which varies in ...
... is a protein that in humans is encoded by the BMND8 gene. "Human PubMed ... "Entrez Gene: Bone mineral density quantitative trait locus 8". Retrieved 2016-06-27. v t e (Articles with short description, ...
Hoeschele I (2004-07-15). "Mapping Quantitative Trait Loci in Outbred Pedigrees". Handbook of Statistical Genetics. John Wiley ... "Identification of trait loci affecting white meat percentage and other growth and carcass traits in commercial broiler chickens ... "Imprinted loci in domestic livestock species as epigenomic targets for artificial selection of complex traits". Animal Genetics ... A single locus will entirely produce one's phenotype although two alleles are inherited. This genotype class is called parental ...
... in linkage disequilibrium with a quantitative trait locus (QTL) that contributes to the trait of interest. Association mapping ... Family-based mapping of quantitative trait loci in plant breeding populations with resistance to Fusarium head blight in wheat ... Hoeschele, I. (2004-07-15). "Mapping Quantitative Trait Loci in Outbred Pedigrees". Handbook of Statistical Genetics. ... is a method of mapping quantitative trait loci (QTLs) that takes advantage of historic linkage disequilibrium to link ...
Replication timing quantitative trait loci affects DNA replication. In order to categorize a mutation as such, the "normal" ... Also, many traits are determined by hundreds of genes (or loci), so that each locus has only a minor effect. For instance, ... Araten DJ, Golde DW, Zhang RH, Thaler HT, Gargiulo L, Notaro R, Luzzatto L (September 2005). "A quantitative measurement of the ... "Locus Specific Mutation Databases". Leiden, the Netherlands: Leiden University Medical Center. Retrieved 18 October 2015. " ...
Worker food preferences have been connected to genotypic variation at specific quantitative trait loci. African bees are " ... "Major quantitative trait loci affecting honey bee foraging behavior". Genetics. 141 (4): 1537-1545. doi:10.1093/genetics/141.4. ... The main difference found between African and European honey bees were a few behavioral traits in the worker bees that were all ... The balancing of evolutionary costs and benefits have shaped the distribution of these genotypic traits. A bee population must ...
RAPSN Fetal hemoglobin quantitative trait locus 1; 141749; HBG1 Fetal hemoglobin quantitative trait locus 1; 141749; HBG2 FG ... POR Anxiety-related personality traits; 607834; SLC6A4 Aortic aneurysm, familial thoracic 4; 132900; MYH11 Aortic aneurysm, ...
Mukeshimana, Gerardine; Butare, Louis; Cregan, Perry B.; Kelly, James D. (May 2014). "Quantitative Trait Loci Associated with ... Mukeshimana, Gerardine; Lasley, Amy L. (May 2014). "Identification of Shoot Traits Related to Drought Tolerance in Common Bean ...
Several additional loci have been identified. Also, several quantitative trait loci for BMI have been identified. Confirmed and ... January 2002). "Quantitative-Trait Loci Influencing Body-Mass Index Reside on Chromosomes 7 and 13: The National Heart, Lung, ... 18 January 2009). "Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in ... January 2009). "Six new loci associated with body mass index highlight a neuronal influence on body weight regulation". Nat. ...
Major quantitative trait loci affecting honey bee foraging behavior. Genetics 141: 1537-1545. Hunt, G. J, and R.E. Page. 1995. ... Complex social behavior derived from maternal reproductive traits. Nature 439: 76-78 [cover article]. Nelson, C.M., K.E. Ihle, ...
As of 2020[update] modern molecular and molecular genetics techniques are identifying quantitative trait loci (QTLs), ... "Quantitative trait loci from identification to exploitation for crop improvement". Plant Cell Reports. Springer Science+ ... "Identification and Validation of a Common Stem Rust Resistance Locus in Two Bi-parental Populations". Frontiers in Plant ... "Association mapping of North American spring wheat breeding germplasm reveals loci conferring resistance to Ug99 and other ...
1996). "A genome-wide search for quantitative trait loci underlying asthma". Nature. 383 (6597): 247-50. Bibcode:1996Natur.383 ...
May 2008). "A genome-wide association study identifies protein quantitative trait loci (pQTLs)". PLOS Genetics. 4 (5): e1000072 ...
2008). Cheung VG (ed.). "A genome-wide association study identifies protein quantitative trait loci (pQTLs)". PLOS Genet. 4 (5 ...
In the case that such a gene is identified, it is referred to as a quantitative trait locus (QTL). These genes are generally ... Zimmerman, Erika; Palsson, Arnar; Gibson, Greg (1 June 2000). "Quantitative Trait Loci Affecting Components of Wing Shape in ... Traits with polygenic determinism correspond to the classical quantitative characters, as opposed to the qualitative characters ... Polygenic locus may be either a single or complex genetic locus in the conventional sense, i.e., either a single gene or ...
"Congenital Sensorineural Deafness in Dalmatian Dogs Associated with Quantitative Trait Loci". PLOS ONE. 8 (12): e80642. Bibcode ... The goal of the project is to preserve and improve the Dalmatian breed by breeding parent dogs with the following traits: ... scientific way to correct genetic health problems associated with certain breed traits and still preserve the integrity of the ...
A genetic study identified two quantitative trait loci (QTL) that control hearing function. One QTL, named age-related hearing ... Drayton, M.; Noben-Trauth, K. (2006). "Mapping quantitative trait loci for hearing loss in Black Swiss mice". Hearing Research ... The locus extends over about 8 kbp and contains the six coding exons that give rise to an open reading frame of 639 nucleotides ... A genetic locus conferring susceptibility was identified (juvenile audiogenic monogenic seizures1, jams1) on chromosome 10. A ...
1996). "A genome-wide search for quantitative trait loci underlying asthma". Nature. 383 (6597): 247-50. Bibcode:1996Natur.383 ...
Quantitative trait locus which relates gene expression to genotypes. Genetic analysis of gene expression. Characterization of ... Genetics of alcohol-associated traits in monkeys. A dedicated section (Pilot projects) launches 2 to 4 projects annually. ...
Cardon LR, Smith SD, Fulker DW, Kimberling WJ, Pennington BF, DeFries JC (October 1994). "Quantitative trait locus for reading ... "Quantitative-trait locus for specific language and reading deficits on chromosome 6p". American Journal of Human Genetics. 64 ( ... Londin ER, Meng H, Gruen JR (June 2003). "A transcription map of the 6p22.3 reading disability locus identifying candidate ...
Genetic disorders polygenes Quantitative trait locus Duarte, Christine W.; Vaughan, Laura K.; Beasley, T. Mark; Tiwari, Hemant ... Continuous traits exhibit normal distribution in population and display a gradient of phenotypes while discontinuous traits ... "Common disorders are quantitative traits". Nature Reviews Genetics. 10 (12): 872-878. doi:10.1038/nrg2670. ISSN 1471-0056. PMID ... the individual either has the trait or does not. However, multifactorial traits may be discontinuous or continuous. ...
Branham, Sandra E.; Stansell, Zachary J.; Couillard, David M.; Farnham, Mark W. (1 March 2017). "Quantitative trait loci ... ISBN 978-0-85199-395-9. Stansell, Zachary; Farnham, Mark; Björkman, Thomas (2019). "Complex Horticultural Quality Traits in ...
"Mapping quantitative trait loci using linkage disequilibrium: marker- versus trait-based methods". Behavior Genetics. 35 (2): ... Gene maps or Qualitative Trait Loci (QTL) maps can be produced using two separate methods. One way uses the frequency of marker ... linkage is defined as the state in which two loci are so close together that alleles of these loci are virtually never ... Learning about linkage of traits in sugar cane has led to more productive and lucrative growth of the crop. Sugar cane is a ...
Butlin, Roger K.; Tregenza, Tom (28 February 1998). "Levels of genetic polymorphism: marker loci versus quantitative traits". ... marker loci versus quantitative traits". Philosophical Transactions of the Royal Society B. 355 (1404): 1865. doi:10.1098/rstb. ... Consequently, organisms with traits that give them an advantage over their competitors are more likely to pass on their traits ... These traits are said to be "selected for." Examples of traits that can increase fitness are enhanced survival and increased ...
May 2018). "PM20D1 is a quantitative trait locus associated with Alzheimer's disease". Nature Medicine. 24 (5): 598-603. doi: ... Methylation at or near the PM20D1 locus has been correlated to body mass index. In humans, the PM20D1 locus has been associated ...
... 's laboratory discovered the first methylation quantitative trait locus associated with Alzheimer's disease, and ... "PM20D1 is a quantitative trait locus associated with Alzheimer's disease". Nature Medicine. 24 (5): 598-603. doi:10.1038/s41591 ...
There is already a complete quantitative trait loci map for the juvenile traits. These plants are a few of the common examples ... Forster MA, Bonser SP (January 2009). "Heteroblastic development and the optimal partitioning of traits among contrasting ... models for the study of gene expression in heteroblastic plants because none of them express obvious heteroblastic traits. ...
There were three quantitative trait loci that explained most of the phenotype variation. Indicators of recent selection were ... Their behavioral traits include guarding, herding, and hunting, and personality traits such as hyper-social behavior, boldness ... Their behavioral traits include guarding, herding, and hunting, retrieving, and scent detection. Their personality traits ... These breeds possess distinct traits related to morphology, which include body size, skull shape, tail phenotype, fur type and ...
Okubo T, Harada S, Higuchi S, Matsushita S (Aug 2002). "Investigation of quantitative trait loci in the CCKAR gene with ...
Expression quantitative trait loci (eQTLs) are genomic loci that explain variation in expression levels of mRNAs. An expression ... Doss S, Schadt EE, Drake TA, Lusis AJ (May 2005). "Cis-acting expression quantitative trait loci in mice". Genome Research. 15 ... Michaelson JJ, Loguercio S, Beyer A (July 2009). "Detection and interpretation of expression quantitative trait loci (eQTL)". ... Epigenome-wide association study Quantitative trait locus (QTL) Transcriptome-wide association study Rockman MV, Kruglyak L ( ...
The type of marker described by statistical association to quantitative variation in a particular phenotypic trait that is ... thought to be controlled by the cumulative action of alleles at multiple loci. ...
We find that PM20D1 is a methylation and expression quantitative trait locus coupled to an AD-risk associated haplotype, which ... In contrast, locus-specific or epigenome-wide association studies (EWAS) have revealed site-specific epigenetic alterations, ... In the past, genome-wide association studies (GWAS) have identified an important number of risk loci associated with AD ... Sanchez-Mut, J.V., Heyn, H., Silva, B.A. et al. PM20D1 is a quantitative trait locus associated with Alzheimers disease. Nat ...
Linkage studies have identified several quantitative trait loci (QTLs) for RD. The QTL on chromosom … ... Refinement of the 6p21.3 quantitative trait locus influencing dyslexia: linkage and association analyses Hum Genet. 2004 Jul; ... Linkage studies have identified several quantitative trait loci (QTLs) for RD. The QTL on chromosome 6p21.3 has been ... Marker-trait associations were assessed by using QTDT (a general test of association for quantitative traits) and the family- ...
Mapeamento de QTL (Quantitative Trait Loci) associados à resistência do maracujá-doce à bacteriose ... Five traits were evaluated: total area of the leaf (TA), age of inoculated leaf fall (IK), area of the leaf´s lesion (LA), area ... identified 26 regions associated with QTL for the five traits, 16 of them related to LA, CA and NEA. The phenotypic variation ... It is suggested that the resistance to bacterial blight is quantitative, with a predominance of additive genetic effects. ...
Chromosomal segments underlying quantitative trait loci for mohair production in Angora goats - Volume 45 ... Angora goatsmohairquantitative trait locichèvres Angoramohairloci à effets quantitatifsAngoramohairloci de rasgos cuantitativos ... Seaton, G., Haley, C.S., Knott, S., Kearsey, M., and Visscher, P. (2002) QTL Express: Mapping quantitative trait loci in simple ... Knott, S.A., Elsen, J.M., and Haley, C.S. (1996) Methods for multiple markers mapping of quantitative trait loci in half-sibs ...
The utility of the map was confirmed by locating quantitative trait loci ( QTL ) for the zebra‐striped trait, which was ... seven quantitative trait loci ( QTL ) were detected for manually collected traits associated with biomass production. Of these ... seven quantitative trait loci ( QTL ) were detected for manually collected traits associated with biomass production. Of these ... Statistical Methods for Mapping Quantitative Trait Loci From a Dense Set of Markers journal, January 1999 * Dupuis, Josée; ...
trait loci (QTLs) governing each character. Between one and six QTLs. were identified for each trait. Most (9/12) traits appear ... Quantitative trait loci affecting differences in floral morphology between two species of monkeyflower (Mimulus). Submitted by ... Home » Quantitative trait loci affecting differences in floral morphology between two species of monkeyflower (Mimulus) ... Quantitative trait loci affecting differences in floral morphology between two species of monkeyflower (Mimulus). ...
The resistance breakdown frequency was a highly heritable trait (h²=0.87). Four loci including additive quantitative trait loci ... Data from: Quantitative trait loci from the host genetic background modulate the durability of a resistance gene: a rational ... Palloix, Alain; Quenouille, Julie; Paulhiac, Estelle; Moury, Benoit (2013). Data from: Quantitative trait loci from the host ... The combination of major resistance genes with quantitative resistance factors is hypothesized as a promising breeding strategy ...
The Mcs7 quantitative trait locus is associated with an increased susceptibility to mammary cancer in congenic rats and an ... Previous genome-wide linkage studies in crosses of these strains identified three WKy resistance quantitative trait loci, Mcs5 ... Of the four known WKy Mcs loci tested, only Mcs7 displayed AI. The pattern of AI in carcinomas from both F1 and Mcs7 congenic ... Find Models new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges ( ...
Strictly speaking, both the biological term Quantitative Trait Locus and its plural Quantitative Trait Loci can be abbreviated ... those who particularly care about Quantitative Trait Loci to not particularly care about an individual Quantitative Trait Locus ... What is the correct abbreviation for the plural Quantitative Trait Loci - QTL or QTLs?. Ask Question ... While QTL may stand for Quantitative Trait Loci, people will read it as QTL and pluralise it accordingly. ...
Various parametric approaches in the statistical literature have been proposed to study the quantitative-trait-loci (QTL) ... In this article, we view the growth curves as functional quantitative traits and propose some semiparametric models to relax ... The genetic study of certain quantitative traits in growth curves as a function of time has recently been of major scientific ... Various parametric approaches in the statistical literature have been proposed to study the quantitative-trait-loci (QTL) ...
Heritable differences in transcribed RNA levels can be mapped as quantitative trait loci (QTLs). Transcribed RNA levels are ... Weighting by heritability for detection of quantitative trait loci with microarray estimates of gene expression. *Kenneth F ... Haley CS, Knott SA: A simple regression method for mapping quantitative trait loci in line crosses using flanking markers. ... Manly, K.F., Wang, J. & Williams, R.W. Weighting by heritability for detection of quantitative trait loci with microarray ...
We previously localized a Quantitative Trait Locus for HPFH in an extensive Asian-Indian kindred to chromosome 6q23. As part of ... is a common multifactorial trait characterized by a modest increase of fetal hemoglobin levels in adults. ... We previously localized a Quantitative Trait Locus for HPFH in an extensive Asian-Indian kindred to chromosome 6q23. As part of ... Genome annotation of a 1.5 Mb region of human chromosome 6q23 encompassing a quantitative trait locus for fetal hemoglobin ...
Quantitative Trait Loci: a meta-analysis. Genetics, 2000, 155, pp.463-473. ⟨hal-02698972⟩ ...
... mapping is an important approach for the study of the genetic architecture of quantitative traits. For perennial species, ... A model for quantitative trait loci mapping, linkage phase, and segregation pattern estimation for a full-sib progeny. Tree ... Quantitative trait loci (QTL) mapping is an important approach for the study of the genetic architecture of quantitative traits ... Multiple traits multiple intervals mapping of quantitative trait loci from outbree.... Differential expression of genes ...
Body mass index quantitative trait locus 10; BMIQ10 disease page. Quantitative data and detailed annnotation of the targets of ... Body mass index quantitative trait locus 10; BMIQ10. GtoPdb Disease Summaries. This section gives an overview of the disease, ... No ligand related data available for Body mass index quantitative trait locus 10; BMIQ10 ...
Expression quantitative trait loci in the developing human brain and their enrichment in neuropsychiatric disorders. Genome ... Expression quantitative trait loci in the developing human brain and their enrichment in neuropsychiatric disorders ... However, to date, there have been no studies that have mapped genome-wide expression quantitative trait loci (eQTL) ... influences on gene expression in the human fetal brain plausibly impact upon a variety of postnatal brain-related traits, ...
Quantitative Trait Loci PubMed MeSh Term *Overview. Overview. subject area of * A 77-kilobase region of chromosome 6p22.2 is ... Mapping quantitative trait loci mediating sensitivity to etomidate Journal Article * Mouse genetic models in alcohol research ... Quantitative trait locus mapping for acute functional tolerance to ethanol in the L x S recombinant inbred panel Journal ... Genetic dissection of quantitative trait locus for ethanol sensitivity in long- and short-sleep mice Journal Article ...
Find Models new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges ( ... Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource ...
A fundamental issue in quantitative trait locus (QTL) mapping is to determine the plausibility of the presence of a QTL at a ...
SciTok is a community for researchers to share their research via videos. Made with ❤ in San Francisco. ...
Such loci are known as cis-expression quantitative trait loci (cis-eQTL). As cis-eQTLs are highly tissue-specific, we asked if ... Such loci are known as cis-expression quantitative trait loci (cis-eQTL). As cis-eQTLs are highly tissue-specific, we asked if ... Variants at IRX4 as prostate cancer expression quantitative trait loci.. X. Xu;W. M. Hussain;J. Vijai;K. Offit;M. A. Rubin; ... Genome-wide association studies (GWAS) have identified numerous prostate cancer-associated risk loci. Some variants at these ...
Quantitative Traits Loci (QTL). In a classical monogenic approach, the presence or absence of a trait follows a dichotomous ... Keywords: SNP, SSR, psychiatric disorders, dopamine, serotonin, polygenic trait, quantitative traits loci, GWAS ... and not as quantitative traits, with a continuum of genetic risk. This quantitative approach allows one to formulate two models ... namely the linkage/association studies and the quantitative traits loci (QTL) approach, are described below. ...
Mapping quantitative trait loci (QTL) using genetic marker information is a time-consuming analysis that has interested the ... Mapping quantitative trait loci (QTL) using genetic marker information is a time-consuming analysis that has interested the ... Graphics Processing Unit-Accelerated Quantitative Trait Loci Detection. Journal of Computational Biology, 2013, 20 (9), pp.672- ...
How to map quantitative trait loci (QTL) with epistasis efficiently and reliably has been a persistent problem for QTL mapping ... How to map quantitative trait loci (QTL) with epistasis efficiently and reliably has been a persistent problem for QTL mapping ... Satagopan JM, Yandell BS, Newton MA, Osborn TC: A Bayesian approach to detect quantitative trait loci using Markov chain Monte ... Broman K, Speed T: A model selection approach for the identification of quantitative trait loci in experimental crosses. J R ...
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Identification and mapping of leaf, stem and stripe rust resistance quantitative trait loci and their interactions in durum ... Identification and mapping of leaf, stem and stripe rust resistance quantitative trait loci and their interactions in durum ... Identification and mapping of leaf, stem and stripe rust resistance quantitative trait loci and their interactions in durum ...
Linkage of DNA Methylation Quantitative Trait Loci to Human Cancer Risk.. Heyn H1, Sayols S2, Moutinho C2, Vidal E2, Sanchez- ... Linkage of DNA Methylation Quantitative Trait Loci ... [Cell Rep. 2014] - PubMed - NCBI. Cell Rep. 2014 Apr 2. pii: S2211-1247( ... DNA methylation quantitative trait loci (meQTL) have been identified through significant associations between the genetic and ... Linkage of DNA Methylation Quantitative Trait Loci ... [Cell Rep. 2014] - PubMed - NCBI ...
FastQTL(1) Quantitative Trait Loci (QTL) mapper in cis for molecular phenotypes ...
  • Linkage studies have identified several quantitative trait loci (QTLs) for RD. The QTL on chromosome 6p21.3 has been independently replicated by several groups and spans a 16.4-Mb (13.8 cM) interval from D6S109 to D6S291. (nih.gov)
  • The genetic control of 12 morphological differences between the flowers of M. lewisii and M. cardinalis was explored in a large linkage mapping population of F-2 plants (n = 465) to provide an accurate estimate of the number and magnitude of effect of quantitative trait loci (QTLs) governing each character. (washington.edu)
  • Between one and six QTLs were identified for each trait. (washington.edu)
  • Four loci including additive quantitative trait loci (QTLs) and epistatic interactions explained together 70% of the variance of pvr23 breakdown frequency. (datadryad.org)
  • Three of the four QTLs controlling pvr23 breakdown frequency were also involved in quantitative resistance, strongly suggesting that QTLs controlling quantitative resistance have a pleiotropic effect on the durability of the major resistance gene. (datadryad.org)
  • From all the above, we would expect the plural to be QTLs unless there was a good reason for those who particularly care about Quantitative Trait Loci to not particularly care about an individual Quantitative Trait Locus. (stackexchange.com)
  • Heritable differences in transcribed RNA levels can be mapped as quantitative trait loci (QTLs). (biomedcentral.com)
  • We use multitrait composite interval mapping to jointly locate and characterize quantitative trait loci (QTLs) underlying interspecific differences in seven floral traits. (bioone.org)
  • We identified 24 floral QTLs, most of which affected multiple traits. (bioone.org)
  • The large number of QTLs affecting each trait (mean = 13, range = 11-15) indicates a strikingly polygenic basis for floral divergence in this system. (bioone.org)
  • This study used a permanent mapping population with 144 recombinant inbred lines (RILs) and 2 828 bin-markers to detect quantitative trait loci (QTLs) associated with mesocotyl length in 2019 and 2020. (chinaagrisci.com)
  • In the present study, a population of 198 recombinant inbred lines (RILs) derived from the cross between a CIMMYT wheat line C615 and Yangmai 13 (YM13) was constructed, followed by genotyping with Wheat 90K SNP array and phenotyping of spike-related traits and plant height in three environments to excavate QTLs (quantitative trait loci) for these traits. (chinacrops.org)
  • Therefore, the identification of quantitative trait loci (QTLs) associated with those for Na+ and K+ uptake, will enable breeders to use marker-assisted selection to transfer QTLs into elite lines in rice improvement programs. (ijbiotech.com)
  • QTLs), 6 (1 QTL), and 8 (2 QTLs) for all six traits except, Sodium (Na+) in the shoot. (ijbiotech.com)
  • The objective of this study was to identify and map quantitative trait loci (QTLs) resistant to soybean rust in genotype UG 5. (uncst.go.ug)
  • Statistically valid linkage between such genomic regions and measurements of quantitative traits are called quantitative trait loci (QTLs). (medscape.com)
  • It is suggested that the resistance to bacterial blight is quantitative, with a predominance of additive genetic effects. (usp.br)
  • The combination of major resistance genes with quantitative resistance factors is hypothesized as a promising breeding strategy to preserve the durability of resistant cultivar, as recently observed in different pathosystems. (datadryad.org)
  • Using the pepper (Capsicum annuum)/Potato virus Y (PVY, genus Potyvirus) pathosystem, we aimed at identifying plant genetic factors directly affecting the frequency of virus adaptation to the major resistance gene pvr23 and at comparing them with genetic factors affecting quantitative resistance. (datadryad.org)
  • The resistance breakdown frequency was a highly heritable trait (h²=0.87). (datadryad.org)
  • Previous genome-wide linkage studies in crosses of these strains identified three WKy resistance quantitative trait loci, Mcs5, Mcs6 and Mcs8, and one predicted to increase susceptibility, Mcs7. (mcw.edu)
  • Precise mapping of quantitative trait loci for resistance to southern leaf blight, caused by Cochliobolus heterostrophus race O, and flowering time using advanced intercross maize lines. (ncsu.edu)
  • Four common SLB resistance quantitative trait loci (QTL) were identified in all environments, two in bin 3.04 and one each in bins 1.10 and 8.02/3. (ncsu.edu)
  • Analysis of quantitative trait loci for resistance to southern leaf blight in juvenile maize. (ncsu.edu)
  • Unlike major gene resistance, partial resistance expressed as an increased latent period appears to be a stable trait expressed over a wide range of temperature and tight conditions, although higher temperatures tended to increase the differences among genotypes. (ncsu.edu)
  • Together, these data suggest that one or more breast cancer-related genes are located within the dominantly acting WKy allele at the Mcs7 locus. (mcw.edu)
  • Human alcoholism studies of genes identified through mouse quantitative trait locus analysis. (colorado.edu)
  • Some variants at these loci may be regulatory and influence expression of nearby genes. (unitn.it)
  • Differentially methylated loci harbor previously reported and as-yet-unidentified cancer genes. (blogspot.com)
  • Together, our results show that individuals in the MOD cluster show aberrant RNA expression of genes that have a suggested causal role on multiple diabetes-relevant traits. (lu.se)
  • As a result, the linkage between the autoimmune experimental arthritis phenotype and the genomic region, that is, the quantitative trait locus, can cover several hundred genes. (medscape.com)
  • We applied our INQUSIT pipeline for prioritizing genes as targets of those potentially causal variants, using gene expression (expression quantitative trait loci), chromatin interaction and functional annotations. (lu.se)
  • We find that PM20D1 is a methylation and expression quantitative trait locus coupled to an AD-risk associated haplotype, which displays enhancer-like characteristics and contacts the PM20D1 promoter via a haplotype-dependent, CCCTC-binding-factor-mediated chromatin loop. (nature.com)
  • Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. (nature.com)
  • DNA methylation quantitative trait loci (meQTL) have been identified through significant associations between the genetic and epigenetic codes in physiological and pathological contexts. (blogspot.com)
  • Expression quantitative trait loci (eQTLs) are genomic loci that explain variation in expression levels of mRNAs. (wikipedia.org)
  • Imputed origins then serve as mean effects in a multivariate Gaussian model for testing association between trait levels and local genomic variation. (arizona.edu)
  • We developed a genomic quantitative genetic approach to overcome this problem, allowing us to examine the function(s) of the plant circadian clock in different populations derived from natural accessions. (plantclock.org)
  • The aims of quantitative trait loci detection is the potential use of these molecular markers to increase accuracy in predicting the genetic merit of breeding and its implementation in animal breeding schemes through marker-assisted selection. (cambridge.org)
  • Several complicated questions are addressed through this evaluation: the dependence of QTL detection power on the QTL effects, residual correlation between the traits, and the effect of epistatic interaction between the QTL for one or both traits on expected LOD (ELOD), etc. (haifa.ac.il)
  • Linkage was assessed by using five quantitative phenotypes, including a composite measure of reading performance and four component phenotypes. (nih.gov)
  • Multivariate genomewide linkage scan of neurocognitive traits and ADHD symptoms: suggestive linkage to 3q13. (colorado.edu)
  • Replication studies, linkage disequilibrium, and imputation analyses highlight population specificity at this locus. (unitn.it)
  • We present the first linkage and Quantitative Trait Loci (QTL) map for Eruca, generated using a population of 139 F4 lines. (reading.ac.uk)
  • Linkage distance between the two loci was 38 map units and the effect of the quantitative trait locus was 1.6 phenotypic standard deviation units. (agri.gov.il)
  • Accurate estimates of the genetic parameters and linkage distance for populations of 2000 individuals simulated with a segregating codominant locus with an effect of 1.63 standard deviations linked to a genetic marker with .2 recombination were also derived by this method. (agri.gov.il)
  • The method is not effective in distinguishing between complete and partial linkage in samples of only 500 individuals or for quantitative loci with effects less than a phenotypic standard deviation. (agri.gov.il)
  • On the use of the moments method of estimation to obtain approximate maximum likelihood estimates of linkage between a genetic marker and a quantitative locus. (agri.gov.il)
  • Power of daughter and granddaughter designs for determining linkage between marker loci and quantitative trait loci in dairy cattle. (agri.gov.il)
  • Phenotypic analyses reveal strong genetic correlations among floral traits and epistatic breakdown of male and female fertility traits in the F 2 hybrids. (bioone.org)
  • Many of these relate directly to complex traits for which liver -specific analyses are likely to be relevant, and we identified dozens of potential connections with disease -associated loci. (bvsalud.org)
  • Quantitative trait loci analyses (log of the odds=15) indicated association of the genetic factor within a few centiMorgan of the best evidence for Ahl [Johnson et al. (cdc.gov)
  • GeneNetwork hosts many large eQTL mapping data sets and provide access to fast algorithms to map single loci and epistatic interactions. (wikipedia.org)
  • As is true in all QTL mapping studies, the final steps in defining DNA variants that cause variation in traits are usually difficult and require a second round of experimentation. (wikipedia.org)
  • The QTL mapping was performed using composite interval and a special strategy for segregating F1 populations, identified 26 regions associated with QTL for the five traits, 16 of them related to LA, CA and NEA. (usp.br)
  • Plant area index ( PAI ) estimated from below‐canopy hemispherical images, as well as a suite of thirteen traits assessed by manual destructive harvests, were measured in a Setaria recombinant inbred line mapping population segregating for aboveground productivity and architecture. (osti.gov)
  • Various parametric approaches in the statistical literature have been proposed to study the quantitative-trait-loci (QTL) mapping of the growth curves as multivariate outcomes. (bepress.com)
  • A model for quantitative trait loci mapping, linka. (fapesp.br)
  • Quantitative trait loci (QTL) mapping is an important approach for the study of the genetic architecture of quantitative traits. (fapesp.br)
  • Mapping quantitative trait loci (QTL) using genetic marker information is a time-consuming analysis that has interested the mapping community in recent decades. (hal.science)
  • How to map quantitative trait loci (QTL) with epistasis efficiently and reliably has been a persistent problem for QTL mapping analysis. (biomedcentral.com)
  • Although mapping quantitative traits in inbred strains is simpler than mapping the analogous traits in humans, classical inbred crosses suffer from reduced genetic diversity compared to experimental designs involving outbred animal populations. (arizona.edu)
  • The previous fastest quantitative trait loci (QTL) mapping software for dense genome scans reduced compute times to hours. (arizona.edu)
  • Molecular mapping and validation of quantitative trait loci for spike-related traits and plant height in wheat[J].Acta Agronomica Sinica, 2022, 48(6): 1346-1356. (chinacrops.org)
  • Maximum likelihood techniques for the mapping and analysis of quantitative trait loci with the aid of genetic markers. (agri.gov.il)
  • Estimating the resolution power of mapping analysis of linked quantitative trait loci (QTL) remains a difficult problem, which has been previously addressed mainly by Monte Carlo simulations. (haifa.ac.il)
  • Ronin, YI , Korol, AB & Nevo, E 1999, ' Single- and multiple-trait mapping analysis of linked quantitative trait loci: Some asymptotic analytical approximations ', Genetics , vol. 151, no. 1, pp. 387-396. (haifa.ac.il)
  • Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue. (bvsalud.org)
  • LE ROY, I. Quantitative Trait Loci (QTL) Mapping. (bvsalud.org)
  • An expression quantitative trait is an amount of an mRNA transcript or a protein. (wikipedia.org)
  • This distinguishes expression quantitative traits from most complex traits, which are not the product of the expression of a single gene. (wikipedia.org)
  • Chromosomal loci that explain variance in expression traits are called eQTLs. (wikipedia.org)
  • By assaying gene expression and genetic variation simultaneously on a genome-wide basis in a large number of individuals, statistical genetic methods can be used to map the genetic factors that underpin individual differences in quantitative levels of expression of many thousands of transcripts. (wikipedia.org)
  • Background Genetic influences on gene expression in the human fetal brain plausibly impact upon a variety of postnatal brain-related traits, including susceptibility to neuropsychiatric disorders. (cardiff.ac.uk)
  • However, to date, there have been no studies that have mapped genome-wide expression quantitative trait loci (eQTL) specifically in the human prenatal brain. (cardiff.ac.uk)
  • We further identify changes in gene expression within the prenatal brain that potentially mediate risk for neuropsychiatric traits, including increased expression of C4A in association with genetic risk for schizophrenia, increased expression of LRRC57 in association with genetic risk for bipolar disorder, and altered expression of multiple genes within the chromosome 17q21 inversion in association with variants influencing the personality trait of neuroticism. (cardiff.ac.uk)
  • Variants at IRX4 as prostate cancer expression quantitative trait loci. (unitn.it)
  • Such loci are known as cis-expression quantitative trait loci (cis-eQTL). (unitn.it)
  • The discovery of expression quantitative trait loci ("eQTLs") can help to unravel genetic contributions to complex traits . (bvsalud.org)
  • Expression quantitative trait loci (eQTLs) for differentially expressed RNAs were obtained from a publicly available dataset. (lu.se)
  • Fig. 2: Long-range chromatin interaction of the rs708727- PM20D1 locus. (nature.com)
  • In the past, genome-wide association studies (GWAS) have identified an important number of risk loci associated with AD pathology 3 , but a causal relationship remains difficult to establish. (nature.com)
  • Genome-wide association studies (GWAS) have identified numerous prostate cancer-associated risk loci. (unitn.it)
  • The Genome-Wide Association Studies approach was used to detect Quantitative Trait Loci associated with tocochromanol concentrations using a panel of 1,466 barley accessions. (oregonstate.edu)
  • To estimate the causal effects of RNAs on traits, a two-sample Mendelian randomisation analysis was performed using public genome-wide association study (GWAS) data. (lu.se)
  • QSN.yaas-3B / QPH.yaas-3B and QSL.yaas-6A / QSC.yaas-6A had not been reported yet, and were likely to be novel loci. (chinacrops.org)
  • Chromosomal segments underlying quantitative trait. (cambridge.org)
  • This study reports the results obtained in the search of chromosomal regions affecting fleece traits in a population of Angora goats in the Argentinean Patagonia. (cambridge.org)
  • As cis-eQTLs are highly tissue-specific, we asked if GWAS-identified prostate cancer risk loci are cis-eQTLs in human prostate tumor tissues. (unitn.it)
  • These results show that the average size of the quantitative trait loci effect was 1.6 phenotypic standard deviations for different traits and families. (cambridge.org)
  • Epistasis is an important, yet difficult, question to study in quantitative genetics. (biomedcentral.com)
  • Modern systems biology permits the study of complex networks, such as circadian clocks, and the use of complex methodologies, such as quantitative genetics. (plantclock.org)
  • This represents a unique and valuable approach to the study of complex networks using quantitative genetics. (plantclock.org)
  • We and 3 with more than 1 aposthia male: fam- think that the person with aposthia trait is a ily DG-01 had 4 living cases, family DG-02 suitable model to study the importance and had 2 living and 1 dead case and family DG- genetics of the prepuce. (who.int)
  • In this article, we view the growth curves as functional quantitative traits and propose some semiparametric models to relax the strong parametric assumptions which may not be always practical in reality. (bepress.com)
  • The type of marker described by statistical association to quantitative variation in a particular phenotypic trait that is thought to be controlled by the cumulative action of alleles at multiple loci . (jax.org)
  • Using two-sample Mendelian randomisation, we found 52 mRNAs to have a causal effect on anthropometric traits (n=23) and lipid metabolism traits (n=10). (lu.se)
  • mRNAs in the MOD cluster showed a possible causal effect on anthropometric traits, lipid metabolism traits and blood cell fractions. (lu.se)
  • In general, the work presented here will be valuable for future efforts to precisely identify and functionally characterize genetic contributions to a variety of complex traits . (bvsalud.org)
  • The steady-state abundance of an RNA species in an organ is, in part, genetically controlled and can be considered a quantitative genetic trait. (biomedcentral.com)
  • With this method, the genetic parameters of a locus affecting plant height linked to an electrophoretic marker for esterase were accurately estimated from a sample of 1596 F-2 progeny of a cross between two species of Lycopersicon (tomato). (agri.gov.il)
  • Marker-trait associations were assessed by using QTDT (a general test of association for quantitative traits) and the family-based association test (FBAT), and haplotype analysis was performed by using FBAT and the GeneHunter Transmission/Disequilibrium Test TDT. (nih.gov)
  • An equivalent eQTL analysis of the same prostate cancer risk loci in lymphoblastoid cell lines did not result in any significant associations. (unitn.it)
  • Quantitative trait loci analysis of glucosinolate, sugar, and organic acid concentrations in Eruca vesicaria subsp. (reading.ac.uk)
  • The analytical method of evaluation of the expected LOD developed in this article spreads the 'deterministic sampling' approach for the case of two linked QTL for single- and two-trait analysis. (haifa.ac.il)
  • Quantitative trait locus analysis of the development of pulmonary tolerance to inhaled zinc oxide. (cdc.gov)
  • The method, which assumes underlying normal distributions, is a combination of maximum likelihood and moments methods and uses the statistics of the genetic marker genotype samples for the quantitative trait to estimate the recombination frequency between the two loci and the means and variances of the genotypes of the quantitative trait locus. (agri.gov.il)
  • The Mcs7 quantitative trait locus is associated with an increased susceptibility to mammary cancer in congenic rats and an allele-specific imbalance. (mcw.edu)
  • Quantitative trait loci controlling light and hormone response in two accessions of Arabidopsis thaliana. (uchicago.edu)
  • Epigenome-wide association study Quantitative trait locus (QTL) Transcriptome-wide association study Rockman MV, Kruglyak L (November 2006). (wikipedia.org)
  • The genetic study of certain quantitative traits in growth curves as a function of time has recently been of major scientific interest to explore the developmental evolution processes of biological subjects. (bepress.com)
  • Five traits were evaluated: total area of the leaf (TA), age of inoculated leaf fall (IK), area of the leaf´s lesion (LA), area of the leaf´s chlorosis (CA) and area of the leaf´s necrosis (NEA). (usp.br)
  • Here, we establish the independent phenotype conferred by Mcs7 using congenic rats carrying the WKy Mcs7 locus on a WF background. (mcw.edu)
  • Tumor multiplicity was significantly higher ( approximately 50%) in DMBA-treated congenics homozygous and heterozygous for the WKy allele at the Mcs7 locus, compared to controls. (mcw.edu)
  • A method is presented to estimate the biometric parameters of a quantitative trait locus linked to a genetic marker when both loci are segregating in the F-2 generation of a cross between two inbred lines. (agri.gov.il)
  • Strictly speaking, both the biological term Quantitative Trait Locus and its plural Quantitative Trait Loci can be abbreviated as QTL . (stackexchange.com)
  • The difficulty mainly lies in the biological complexity of epistasis of quantitative trait loci (QTL). (biomedcentral.com)
  • We previously localized a Quantitative Trait Locus for HPFH in an extensive Asian-Indian kindred to chromosome 6q23. (biomedcentral.com)
  • Sodium (Na+), while maintaining Potassium (K+) uptake in rice are traits that would aid in salinity tolerance. (ijbiotech.com)