Compounds containing dibenzo-1,4-thiazine. Some of them are neuroactive.
A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.
The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
A phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.
A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612)
A phenothiazine used as an antipsychotic agent and as an antiemetic.
A phenothiazine used in the treatment of PSYCHOSES. Its properties and uses are generally similar to those of CHLORPROMAZINE.
A traditional grouping of drugs said to have a soothing or calming effect on mood, thought, or behavior. Included here are the ANTI-ANXIETY AGENTS (minor tranquilizers), ANTIMANIC AGENTS, and the ANTIPSYCHOTIC AGENTS (major tranquilizers). These drugs act by different mechanisms and are used for different therapeutic purposes.
A phenothiazine with actions similar to CHLORPROMAZINE. It is used as an antipsychotic and an antiemetic.
An antipsychotic phenothiazine derivative with actions and uses similar to those of CHLORPROMAZINE.
A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.
A phenothiazine with pharmacological activity similar to that of both CHLORPROMAZINE and PROMETHAZINE. It has the histamine-antagonist properties of the antihistamines together with CENTRAL NERVOUS SYSTEM effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)
A phenothiazine antipsychotic with actions and uses similar to those of CHLORPROMAZINE. Extrapyramidal symptoms may be more common than other side effects.
A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457)
Compounds containing phenyl-1-butanone.
A delayed hypersensitivity involving the reaction between sunlight or other radiant energy source and a chemical substance to which the individual has been previously exposed and sensitized. It manifests as a papulovesicular, eczematous, or exudative dermatitis occurring chiefly on the light-exposed areas of the skin.
A very effective anticoccidial agent used in poultry.

Research and identification of tranquillizers - use of retention index. (1/323)

At the request of the Service des Haras, our laboratory works on the toxicological problems of the sport-horse. These studies have resulted in the setting up of an anti-doping control for equestrian competitions of various types, not only flat racing. During events, horses, must be calm and docile to the riders' order. Frequently, the latter use tranquillizers to try and win events. The analytical method for the research and identification of these compounds is described. The technique involves successively: 1. alkalinisation of the sample - saliva, blood or urine after enzymatic hydrolysis. 2. extraction with diethyl ether - the recovery is 70% to 90% depending upon the drug. 3. determination by gas-liquid chromatography with use of a retention index for qualitative analysis. We can detect up to fifteen tranquillizers in any one sample, even when present at such low concentrations as found in saliva. The use of the retention index is a reliable method for qualitative analysis. For example, the method has been used for three years, during which period the rentention index of acetylpromazine remained at 3240 +/- 7. The chromatographic analysis was performed on 3% OV-17 at 290 degrees. The chromatographic analysis has been performed by three columns of different polarity (OV-1; OV-17; SP-2250). If on the three columns, the retention index of one peak is the same as that of the tranquilizer, a further confirmation is made with the use of a thermionic detector specific for nitrogenous drugs. In conclusion, this method which is sufficiently precise and specific has been used for anti-doping control.  (+info)

Model ecosystem evaluation of the environmental impacts of the veterinary drugs phenothiazine, sulfamethazine, clopidol, and diethylstilbestrol. (2/323)

Four veterinary drugs of dissimilar chemical structures were evaluated for environmental stability and penchant for bioaccumulation. The techniques used were (1) a model aquatic ecosystem (3 days) and (2) a model feedlot ecosystem (33 days) in which the drugs were introduced via the excreta of chicks or mice. The model feedlot ecosystem was supported by metabolism cage studies to determine the amount and the form of the drug excreted by the chicks or mice. Considerable quantities of all the drugs were excreted intact or as environmentally short-lived conjugates. Diethylstilbestrol (DES) and Clopidol were the most persistent molecules, but only DES bioaccumulated to any appreciable degree. Phenothiazine was very biodegradable; sulfamethazine was relatively biodegradable and only accumulated in the organisms to very low levels. Data from the aquatic model ecosystem demonstrated a good correlation between the partition coefficients of the drugs and their accumulation in the fish.  (+info)

Risk of breast cancer according to use of antidepressants, phenothiazines, and antihistamines. (3/323)

In laboratory studies, some antidepressants caused increased growth of mammary tumors. The relation of use of these drugs to the development of breast cancer was examined in a hospital-based case-control study. Information, including lifetime medication history, was collected by interview from 5,814 women with primary breast cancer diagnosed within the previous year, 5,095 women with primary malignancies of other sites, and 5,814 women with other conditions. Relative risks were estimated by using unconditional multiple logistic regression for regular use (> or =4 days per week for > or =4 weeks beginning > or =1 year before admission) of antidepressants and structurally similar drugs. With reference to never use of each drug, relative risks were statistically compatible with 1.0 for selective serotonin reuptake inhibitors (SSRI), tricyclics, other antidepressants, phenothiazines, and antihistamines; results were very similar using both control groups. There were no significant increases in risk for any category of regular use, stratified according to cumulative duration of use or time interval since the most recent use or for any individual drug within the broader classes. However, the estimate for regular SSRI use in the previous year, 1.8, was of borderline statistical significance (95% confidence interval: 1.0, 3.3). The findings do not support an overall association between the use of antidepressants, phenothiazines, or antihistamines and breast cancer. However, the results for SSRIs are not entirely reassuring.  (+info)

Permeabilization of fungal membranes by plant defensins inhibits fungal growth. (4/323)

We used an assay based on the uptake of SYTOX Green, an organic compound that fluoresces upon interaction with nucleic acids and penetrates cells with compromised plasma membranes, to investigate membrane permeabilization in fungi. Membrane permeabilization induced by plant defensins in Neurospora crassa was biphasic, depending on the plant defensin dose. At high defensin levels (10 to 40 microM), strong permeabilization was detected that could be strongly suppressed by cations in the medium. This permeabilization appears to rely on direct peptide-phospholipid interactions. At lower defensin levels (0.1 to 1 microM), a weaker, but more cation-resistant, permeabilization occurred at concentrations that correlated with the inhibition of fungal growth. Rs-AFP2(Y38G), an inactive variant of the plant defensin Rs-AFP2 from Raphanus sativus, failed to induce cation-resistant permeabilization in N. crassa. Dm-AMP1, a plant defensin from Dahlia merckii, induced cation-resistant membrane permeabilization in yeast (Saccharomyces cerevisiae) which correlated with its antifungal activity. However, Dm-AMP1 could not induce cation-resistant permeabilization in the Dm-AMP1-resistant S. cerevisiae mutant DM1, which has a drastically reduced capacity for binding Dm-AMP1. We think that cation-resistant permeabilization is binding site mediated and linked to the primary cause of fungal growth inhibition induced by plant defensins.  (+info)

Dopamine receptor binding in the corpus striatum of mammalian brain. (5/323)

Specific binding of [3H]dopamine to membranes from the corpus striatum of rat and calf brain appears to involve the postsynaptic dopamine receptor. Specific [3H]dopamine binding is saturable, wnd with half-maximal binding in calf membranes at 7 nM. Apomorphine is about twice as potent as dopamine in competing for binding sites, whereas (-)norepinephrine is 5% as potent as dopamine and isoproterenol is virtually inactive. The relative potencies of phenothiazines as inhibitors of specific dopamine binding correlates with their clinical potencies and actions on the dopamine-sensitive adenylate cyclase.  (+info)

The specificity of protein-DNA crosslinking by formaldehyde: in vitro and in drosophila embryos. (6/323)

Formaldehyde crosslinking has been widely used to study binding of specific proteins to DNA elements in intact cells. However, previous studies have not determined if this crosslinker preserves the bona fide pattern of DNA binding. Here we show that formaldehyde crosslinking of Drosophila embryos maps an interaction of the transcription factor Zeste to a known target element in the Ultrabithorax promoter. This data agrees broadly with previous mapping of the same Zeste binding sites by in vivo UV crosslinking, though the formaldehyde method does give a low, possibly artifactual signal on other DNA fragments that is not detected by the UV method. We also demonstrate, using an in vitro assay, that formaldehyde crosslinking accurately reflects the DNA binding specificities of both Zeste and a second transcription factor, Eve. The crosslinking reagent methylene blue is shown to preserve DNA binding specificity in vitro as well. Our results suggest that crosslinking by formaldehyde, and possibly also by methylene blue, provide an accurate guide to the interaction of proteins with their high affinity target sites in cells.  (+info)

Hydroperoxide specificity of plant and human tissue lipoxygenase: an in vitro evaluation using N-demethylation of phenothiazines. (7/323)

Since hydroperoxide specificity of lipoxygenase (LO) is poorly understood at present, we investigated the ability of cumene hydroperoxide (CHP) and tert-butyl hydroperoxide (TBHP) to support cooxidase activity of the enzyme toward the selected xenobiotics. Considering the fact that in the past, studies of xenobiotic N-demethylation have focused on heme-proteins such as P450 and peroxidases, in this study, we investigated the ability of non-heme iron proteins, namely soybean LO (SLO) and human term placental LO (HTPLO) to mediate N-demethylation of phenothiazines. In addition to being dependent on peroxide concentration, the reaction was dependent on enzyme concentration, substrate concentration, incubation time, and pH of the medium. Using Nash reagent to estimate formaldehyde production, the specific activity under optimal assay conditions for the SLO mediated N-demethylation of chlorpromazine (CPZ), a prototypic phenothiazine, in the presence of TBHP, was determined to be 117+/-12 nmol HCHO/min/mg protein, while that of HTPLO was 3.9+/-0.40 nmol HCHO/min/mg protein. Similar experiments in the presence of CHP yielded specific activities of 106+/-11 nmol HCHO/min/mg SLO, and 3.2+/-0.35 nmol HCHO/min/mg HTPLO. As expected, nordihydroguaiaretic acid and gossypol, the classical inhibitors of LOs, as well as antioxidants and free radical reducing agents, caused a marked reduction in the rate of formaldehyde production from CPZ by SLO in the reaction media fortified with either CHP or TBHP. Besides chlorpromazine, both SLO and HTPLO also mediated the N-demethylation of other phenothiazines in the presence of these organic hydroperoxides.  (+info)

Associations between epidermal thionin-positive cells and skin parasitic infections in brown trout Salmo trutta. (8/323)

The dynamics of the densities of epidermal thionin-positive cells (putative mast cells) in the skin of brown trout fry were investigated during experimental infections with the skin parasites Ichthyophthirius multifiliis (Ciliophora) and Gyrodactylus derjavini (Monogenea). It was shown that the metachromatic thionin-stained cells were extremely sensitive to parasite exposure, as the density of cells in the skin of trout decreased markedly after exposure to the pathogens. As early as 7 d post infection the cell counts were significantly reduced and almost totally depleted following 9 d infection, which suggests that degranulation of the cells occurs following parasite exposure. No recruitment of new cells was seen during the study period. Some reduction in uninfected control groups indicates that the putative mast cells are sensitive to stress as well. A notable variation in densities of thionin-stained cells between different fins was found and the corneal surface was devoid of these cells. The possible implications of these cells in host-parasite interactions are suggested and discussed.  (+info)

Phenothiazines are a class of heterocyclic organic compounds that contain a phenothiazine nucleus, which consists of a pair of benzene rings fused to a thiazine ring. They have been widely used in medicine as antipsychotic drugs for the treatment of various mental disorders such as schizophrenia and bipolar disorder.

Phenothiazines work by blocking dopamine receptors in the brain, which helps to reduce the symptoms of psychosis such as hallucinations, delusions, and disordered thinking. They also have sedative and antiemetic (anti-nausea) effects. However, they can cause a range of side effects including extrapyramidal symptoms (involuntary muscle movements), tardive dyskinesia (irreversible movement disorder), and neuroleptic malignant syndrome (a rare but potentially fatal reaction to antipsychotic drugs).

Examples of phenothiazine drugs include chlorpromazine, thioridazine, and promethazine. While they have been largely replaced by newer atypical antipsychotics, phenothiazines are still used in some cases due to their lower cost and effectiveness in treating certain symptoms.

Thioridazine is an antipsychotic medication that belongs to the class of phenothiazines. It works by blocking dopamine receptors in the brain, which helps to reduce psychotic symptoms such as delusions, hallucinations, and disordered thought processes. Thioridazine is used to treat schizophrenia and other mental disorders associated with anxiety, agitation, or hostility.

It's important to note that thioridazine has been associated with serious side effects, including prolongation of the QT interval on the electrocardiogram (ECG), which can lead to potentially fatal arrhythmias. Therefore, its use is generally reserved for patients who have not responded to other antipsychotic medications or who cannot tolerate them. Thioridazine has been withdrawn from the market in many countries due to these safety concerns.

Chlorpromazine is a type of antipsychotic medication, also known as a phenothiazine. It works by blocking dopamine receptors in the brain, which helps to reduce the symptoms of psychosis such as hallucinations, delusions, and disordered thinking. Chlorpromazine is used to treat various mental health conditions including schizophrenia, bipolar disorder, and severe behavioral problems in children. It may also be used for the short-term management of severe anxiety or agitation, and to control nausea and vomiting.

Like all medications, chlorpromazine can have side effects, which can include drowsiness, dry mouth, blurred vision, constipation, weight gain, and sexual dysfunction. More serious side effects may include neurological symptoms such as tremors, rigidity, or abnormal movements, as well as cardiovascular problems such as low blood pressure or irregular heart rhythms. It is important for patients to be monitored closely by their healthcare provider while taking chlorpromazine, and to report any unusual symptoms or side effects promptly.

Promazine is a type of medication known as a phenothiazine antipsychotic. It works by blocking the action of dopamine, a neurotransmitter in the brain that is involved in emotion and thought. Promazine is primarily used to treat schizophrenia and other psychotic disorders, as well as to manage agitation and anxiety in certain medical conditions. It may also be used for its sedative effects in the management of insomnia or related sleep disturbances.

Promazine was first synthesized in the 1940s and has been used in clinical practice since then. It is available in various forms, including tablets and injectable solutions, and is typically administered two to four times a day. Common side effects of promazine include dry mouth, blurred vision, constipation, dizziness, and orthostatic hypotension (a sudden drop in blood pressure upon standing). Less commonly, it can cause extrapyramidal symptoms, such as tremors, rigidity, and akathisia (restlessness and inability to sit still).

It is important to note that promazine and other phenothiazine antipsychotics have been largely replaced by newer, atypical antipsychotic medications due to their greater efficacy and lower risk of extrapyramidal side effects. However, promazine may still be used in certain cases where its specific properties are desired or when other treatments have failed. As with any medication, it should only be used under the close supervision of a healthcare provider, who can monitor for potential adverse effects and adjust the dosage as needed.

Prochlorperazine is an antipsychotic drug, specifically a phenothiazine derivative. It works by blocking dopamine receptors in the brain, which helps to reduce psychotic symptoms such as hallucinations and delusions, and also has antiemetic (anti-nausea and vomiting) effects.

Prochlorperazine is used to treat various conditions, including:

* Schizophrenia and other psychotic disorders
* Nausea and vomiting, including motion sickness and postoperative nausea and vomiting
* Severe anxiety or agitation
* Tension headaches

The drug can be administered orally, intramuscularly, or rectally, depending on the formulation. Common side effects of prochlorperazine include drowsiness, dry mouth, blurred vision, and constipation. More serious side effects can include neurological symptoms such as tardive dyskinesia (involuntary movements), neuroleptic malignant syndrome (a life-threatening condition characterized by fever, muscle rigidity, and autonomic dysfunction), and seizures. Prochlorperazine should be used with caution in elderly patients, those with a history of seizures or cardiovascular disease, and those taking other medications that may interact with it.

Triflupromazine is an antipsychotic medication that belongs to the class of phenothiazines. It works by blocking dopamine receptors in the brain, which helps to reduce psychotic symptoms such as hallucinations, delusions, and hostility.

The medical definition of Triflupromazine is:

A trifluoromethyl phenothiazine antipsychotic drug, with sedative and hypotensive effects. It is used in the management of chronic schizophrenia, agitated states, and severe behavior problems in children. Its side effects include extrapyramidal symptoms (EPS), such as tremors, rigidity, and akathisia, as well as anticholinergic effects like dry mouth and constipation. It may also cause orthostatic hypotension, drowsiness, and weight gain.

Fluphenazine is an antipsychotic medication that belongs to the class of phenothiazines. It works by blocking the action of dopamine, a neurotransmitter in the brain, which helps to reduce the symptoms of psychosis such as delusions, hallucinations, and disordered thought.

Fluphenazine is available in several forms, including oral tablets, orally disintegrating tablets, and injectable solutions. It may be used for the treatment of schizophrenia, psychotic disorders, and other conditions associated with elevated levels of dopamine in the brain.

Like all antipsychotic medications, fluphenazine can cause side effects, including extrapyramidal symptoms (EPS), such as stiffness, tremors, and spasms of the face and neck muscles, as well as other systemic side effects like weight gain, sedation, and orthostatic hypotension. It is essential to use fluphenazine under the close supervision of a healthcare provider who can monitor for side effects and adjust the dosage accordingly.

Tranquilizing agents, also known as major tranquilizers or antipsychotic drugs, are a class of medications used primarily to manage psychosis, including schizophrenia, and other mental health disorders. These agents work by blocking dopamine receptors in the brain, which helps reduce the symptoms of psychosis such as hallucinations, delusions, and disordered thinking.

Tranquilizing agents can be further divided into two categories: first-generation antipsychotics (FGAs) and second-generation antipsychotics (SGAs). FGAs, also known as typical antipsychotics, were developed earlier and have a higher risk of side effects such as extrapyramidal symptoms (EPS), which include involuntary movements, stiffness, and tremors. SGAs, also known as atypical antipsychotics, were developed more recently and have a lower risk of EPS but may have other side effects such as weight gain and metabolic issues.

It's important to note that tranquilizing agents should only be prescribed and monitored by a qualified healthcare professional, as they can have significant risks and benefits.

Trifluoperazine is an antipsychotic medication that belongs to the class of drugs called phenothiazines. It works by blocking the action of dopamine, a neurotransmitter in the brain, and helps to reduce symptoms of schizophrenia such as hallucinations, delusions, paranoia, and disordered thought. Trifluoperazine may also be used to manage anxiety or agitation in certain medical conditions. It is available in the form of tablets for oral administration. As with any medication, trifluoperazine should be taken under the supervision of a healthcare provider due to potential side effects and risks associated with its use.

Perphenazine is an antipsychotic medication that belongs to the class of phenothiazines. It works by blocking dopamine receptors in the brain, which helps to reduce psychotic symptoms such as delusions, hallucinations, and disordered thinking. Perphenazine is used to treat various mental disorders, including schizophrenia, psychotic disorders, and severe agitation or aggression in people with developmental disabilities. It may also be used for the short-term treatment of severe anxiety or depression that does not respond to other treatments.

Perphenazine can cause side effects such as drowsiness, dizziness, restlessness, dry mouth, constipation, and weight gain. More serious side effects may include neurological symptoms such as tremors, stiffness, and uncontrolled muscle movements, which may indicate a condition called tardive dyskinesia. Perphenazine can also cause cardiovascular side effects such as low blood pressure, irregular heartbeat, and increased heart rate. It is important to monitor patients taking perphenazine for these and other potential side effects.

It's worth noting that the use of antipsychotic medications like perphenazine should be based on a thorough evaluation of the patient's symptoms, medical history, and other factors. The decision to prescribe this medication should be made carefully, taking into account its benefits and risks, as well as any alternative treatment options.

Promethazine is an antihistamine and phenothiazine derivative, which is commonly used for its sedative, anti-emetic (prevents vomiting), and anti-allergic properties. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms, and by blocking the action of dopamine, a neurotransmitter in the brain that helps transmit signals.

Promethazine is used to treat various conditions such as allergies, motion sickness, nausea and vomiting, and as a sedative before and after surgery or medical procedures. It may also be used for its calming effects in children with certain behavioral disorders.

Like all medications, promethazine can have side effects, including drowsiness, dry mouth, blurred vision, and dizziness. More serious side effects may include seizures, irregular heartbeat, and difficulty breathing. It is important to follow the instructions of a healthcare provider when taking promethazine and to report any unusual symptoms or side effects promptly.

Antipsychotic agents are a class of medications used to manage and treat psychosis, which includes symptoms such as delusions, hallucinations, paranoia, disordered thought processes, and agitated behavior. These drugs work by blocking the action of dopamine, a neurotransmitter in the brain that is believed to play a role in the development of psychotic symptoms. Antipsychotics can be broadly divided into two categories: first-generation antipsychotics (also known as typical antipsychotics) and second-generation antipsychotics (also known as atypical antipsychotics).

First-generation antipsychotics, such as chlorpromazine, haloperidol, and fluphenazine, were developed in the 1950s and have been widely used for several decades. They are generally effective in reducing positive symptoms of psychosis (such as hallucinations and delusions) but can cause significant side effects, including extrapyramidal symptoms (EPS), such as rigidity, tremors, and involuntary movements, as well as weight gain, sedation, and orthostatic hypotension.

Second-generation antipsychotics, such as clozapine, risperidone, olanzapine, quetiapine, and aripiprazole, were developed more recently and are considered to have a more favorable side effect profile than first-generation antipsychotics. They are generally effective in reducing both positive and negative symptoms of psychosis (such as apathy, anhedonia, and social withdrawal) and cause fewer EPS. However, they can still cause significant weight gain, metabolic disturbances, and sedation.

Antipsychotic agents are used to treat various psychiatric disorders, including schizophrenia, bipolar disorder, major depressive disorder with psychotic features, delusional disorder, and other conditions that involve psychosis or agitation. They can be administered orally, intramuscularly, or via long-acting injectable formulations. The choice of antipsychotic agent depends on the individual patient's needs, preferences, and response to treatment, as well as the potential for side effects. Regular monitoring of patients taking antipsychotics is essential to ensure their safety and effectiveness.

Methotrimeprazine is a phenothiazine derivative with antiemetic, antipsychotic, and sedative properties. It works as a dopamine receptor antagonist and has been used in the management of various conditions such as nausea and vomiting, schizophrenia, anxiety, and agitation.

It is important to note that Methotrimeprazine can have significant side effects, including sedation, orthostatic hypotension, extrapyramidal symptoms (such as involuntary movements), and neuroleptic malignant syndrome (a rare but potentially life-threatening reaction). Its use should be under the supervision of a healthcare professional, and it is important to follow their instructions carefully.

Perazine is not a medical term itself, but it's a common name for the antipsychotic medication called "perazine hydrochloride." Here's the medical definition:

Perazine Hydrochloride: A first-generation antipsychotic drug primarily used to treat chronic schizophrenia and related psychotic disorders. It belongs to the class of diphenylbutylpiperidine derivatives and works by blocking dopamine receptors in the brain, which helps reduce the symptoms of psychosis such as hallucinations, delusions, and disordered thought processes. Perazine hydrochloride may also have some sedative and antiemetic properties. Common side effects include extrapyramidal symptoms (involuntary muscle movements), dry mouth, blurred vision, constipation, and orthostatic hypotension.

Thiethylperazine is a phenothiazine derivative and an antipsychotic drug, which is primarily used to manage nausea and vomiting. It works by blocking the action of dopamine, a neurotransmitter in the brain that helps regulate various functions, including mood and movement. By blocking dopamine receptors, thiethylperazine can help reduce feelings of nausea and prevent vomiting.

It is important to note that thiethylperazine has sedative effects and can cause significant drowsiness, which should be taken into account when administering this medication. Additionally, like other phenothiazine derivatives, thiethylperazine can have extrapyramidal side effects, such as involuntary muscle spasms, tremors, and stiffness, particularly at higher doses.

As with any medication, thiethylperazine should only be used under the guidance of a healthcare professional, who can monitor its effectiveness and potential side effects.

Butyrophenones are a group of synthetic antipsychotic drugs that are primarily used to treat symptoms of schizophrenia and other psychotic disorders. They act as dopamine receptor antagonists, which means they block the action of dopamine, a neurotransmitter in the brain associated with mood, motivation, and pleasure.

Some examples of butyrophenones include haloperidol, droperidol, and benperidol. These drugs are known for their potent antipsychotic effects and can also be used to manage agitation, aggression, and other behavioral disturbances in patients with various psychiatric and neurological disorders.

In addition to their antipsychotic properties, butyrophenones have been used off-label for their sedative and analgesic effects. However, they are associated with a range of side effects, including extrapyramidal symptoms (EPS), such as involuntary muscle spasms and tremors, as well as other neurological and cardiovascular adverse reactions. Therefore, their use is typically reserved for cases where other treatments have been ineffective or contraindicated.

Photoallergic dermatitis is a type of contact dermatitis that occurs as a result of an allergic reaction to a substance after it has been exposed to ultraviolet (UV) light. This means that when the substance (allergen) comes into contact with the skin and is then exposed to UV light, usually from the sun, an immune response is triggered, leading to an inflammatory reaction in the skin.

The symptoms of photoallergic dermatitis include redness, swelling, itching, and blistering or crusting of the skin. These symptoms typically appear within 24-72 hours after exposure to the allergen and UV light. The rash can occur anywhere on the body but is most commonly found in areas that have been exposed to the sun, such as the face, neck, arms, and hands.

Common allergens that can cause photoallergic dermatitis include certain medications, fragrances, sunscreens, and topical skin products. Once a person has become sensitized to a particular allergen, even small amounts of it can trigger a reaction when exposed to UV light.

Prevention measures for photoallergic dermatitis include avoiding known allergens, wearing protective clothing, and using broad-spectrum sunscreens that protect against both UVA and UVB rays. If a reaction does occur, topical corticosteroids or oral antihistamines may be prescribed to help relieve symptoms.

Clopidol is a veterinary medication used primarily in poultry to prevent the formation of blood clots. It is an antithrombotic agent that works by inhibiting the aggregation of platelets, which are small cells in the blood that help form clots. Clopidol is available as a feed additive and is often used to prevent or treat conditions such as thromboembolic disease and ascites in chickens.

It's important to note that Clopidol is not approved for use in humans, and it should be handled with care by individuals who work with the medication in a veterinary setting. As with any medication, it should only be used under the guidance of a licensed veterinarian.

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Goldberg reaction completed the formation of the phenothiazine ring and gave N,N-dimethyl-10H-phenothiazine-2-sulfonamide [1090 ... Thioproperazine, sold under the brand name Majeptil, is a typical antipsychotic of the phenothiazine group which is used as a ... 272-. ISBN 978-94-011-4439-1. "Phenothiazines (Systemic)". Drugs.com. "Thioproperazine - Oral". Retrieved 2018-09-16. " ... Phenothiazines, Piperazines, Sulfonamides, Typical antipsychotics, All stub articles, Nervous system drug stubs). ...
"Synthesis of Phenothiazines. VI. Certain 2-Substituted Phenothiazines and Their 10-Aminoalkyl Derivatives". The Journal of ... Cyamemazine (Tercian), also known as cyamepromazine, is a typical antipsychotic drug of the phenothiazine class which was ... Cyamemazine differs from other phenothiazine neuroleptics in that aside from the usual profile of dopamine, α1-adrenergic, H1, ... Phenothiazines, Serotonin receptor antagonists, Typical antipsychotics, All stub articles, Psychoactive drug stubs). ...
It is of the phenothiazine chemical class. It was approved for medical use in the United States in 1959. Trifluoperazine is an ... Boet DJ (July 1970). "Toxic effects of phenothiazines on the eye". Documenta Ophthalmologica. Advances in Ophthalmology. 28 (1 ...
... and other phenothiazines have been demonstrated to possess antimicrobial properties, but are not currently used ... Richter PA, Burk MP (July-August 1992). "The potentiation of narcotic analgesics with phenothiazines". The Journal of Foot ... By using the technique of functional neurochemical assay chlorpromazine and phenothiazine derivatives have been shown to have ... In 1947, it synthesized promethazine, a phenothiazine derivative, which was found to have more pronounced sedative and ...
In 1954, he published a paper, The Chemistry of Phenothiazine, a classic in the field from which anti-psychotic medications ... Massie, Samuel P. (1 October 1954). "The Chemistry of Phenothiazine". Chemical Reviews. 54 (5): 797-833. doi:10.1021/ ... including the chemistry of phenothiazine. As one of the African American scientists and technicians on the Manhattan Project to ...
Specific examples include anticholinergics, diuretics, phenothiazines and barbiturates. Heat stroke is relatively common in ...
Chemically, it is classified as a piperazinyl phenothiazine. Originally marketed in the United States as Trilafon, it has been ... A 2015 systematic review compared perphenazine with other antipsychotic drugs: As a member of the phenothiazine type of ... Rees L (August 1960). "Chlorpromazine and allied phenothiazine derivatives". British Medical Journal. 2 (5197): 522-5. doi: ... Phenothiazines, Piperazines, Sigma receptor ligands, Typical antipsychotics). ...
It is a phenothiazine derivative. Rada RT, Donlon PT (February 1974). "Piperacetazine in ambulatory chronic schizophrenic ...
Phenothiazines are particularly effective in treating opioid-induced PONV. Adverse effects are dose-dependent and include ...
... is an antipsychotic drug of the phenothiazines class. It was synthesized by Wilhelm Schuler and colleagues at ... US patent 3040043, Schuler et al., "3-trifluoromethyl-10-[3'-(4"-(2"'-hydroxy ethyl)-homopiperazino)-propyl]-phenothiazine and ... Phenothiazine [92-30-8] (1) and 1-(3-bromopropyl)-1,4-diazepane (2) led to 10-[3-(1,4-diazepan-1-yl)propyl]-2-(trifluoromethyl) ... phenothiazine, CID:110174391 (3). Further alkylation with 2-Chloroethanol [107-07-3] (4) completed the synthesis of ...
Phenothiazines and 1,4-benzothiazines: Chemical and Biomedical Aspects. Elsevier. p. 688. ISBN 978-0-444-42967-4. Viscoleo® is ...
Low blood pressure caused by phenothiazines, hypertension, and pheochromocytoma. Patients receiving monoamine oxidase ...
... (Tindal) is a typical antipsychotic of the phenothiazine class. Typical antipsychotic Phenothiazine Quitkin FM ( ... Phenothiazines, Piperazines, Typical antipsychotics, All stub articles, Nervous system drug stubs). ...
... (Artalan, Dartal, Dartalan, Dartan) is a typical antipsychotic of the phenothiazine class. It is a prodrug to ... Typical antipsychotic Phenothiazine Buckingham J (1996). Dictionary of organic compounds. London: Chapman & Hall. p. 5148. ISBN ... phenothiazine [2765-59-5] (1) with Piperazine (2) gives N-Desmethylprochlorperazine [40323-85-1] (3). Further alkylation with 2 ... Phenothiazines, Piperazines, Typical antipsychotics, All stub articles, Nervous system drug stubs). ...
The major structural difference is that the nitrogen at position 10 in the phenothiazines is replaced by a carbon atom with a ... It is also related to phenothiazine. Several of its derivatives are used as typical antipsychotics in the treatment of ... The thioxanthenes, as a class, are closely related chemically to the phenothiazines. ...
"Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines". Proceedings of the National Academy of ... "Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins". The Journal of Biological ...
Typical antipsychotic Phenothiazine Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, ... Butaperazine (Repoise, Tyrylen) is a typical antipsychotic of the phenothiazine class. It was approved in 1967, and possibly ... Phenothiazines, Piperazines, Aromatic ketones, Typical antipsychotics, Propyl compounds, All stub articles, Nervous system drug ...
... (INN), also known as mepazine (trade name Pacatal), is a phenothiazine formerly used as a neuroleptic drug or major ... Sherman S, Baur E, Klahre H, Lever PG (February 1958). "Agranulocytosis after 10(N-methyl-piperdyl-3-methyl)phenothiazine, with ... As early as 1958, however, studies reported inferiority to other phenothiazines in the treatment of schizophrenia and ... Casey JF, Lasky JJ, Klett CJ, Hollister LE (August 1960). "Treatment of schizophrenic reactions with phenothiazine derivatives ...
... is similar to drugs such as phenothiazines, tricyclic antidepressants, and clonidine. As an anesthetic, it is ... Its chemical structure closely resembles the phenothiazines, tricyclic antidepressants, and clonidine. Xylazine is absorbed, ...
"Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia". Journal of Clinical Investigation. 124 ( ... in neuroblastoma Discovery of MET-HGF autocrine axis in AML Core transcriptional circuitry of TAL1 complex Phenothiazines ...
At high doses in combination with phenothiazines, it could produce convulsions. Index Nominum 2000: International Drug ...
These medicines are also effective after nausea develops, as are phenothiazines. Each person's sensitivity to nausea and ...
Derivatives of phenothiazines had an important impact on various aspects of medicine, beginning with methylene blue which was ... Phenothiazines were used as antimalarials, antiseptics, and antihelminthics up to 1940. The "psychopharmacological revolution" ...
... introduced phenothiazine as an insecticide in 1935. DuPont was one of an estimated 150 American companies that provided ...
... is a formal derivative of phenothiazine. It is a dark green powder that yields a blue solution in water. The ... Phenothiazine dyes and light have been known to have virucidal properties for over 70 years. Hamilton R (2015). Tarascon Pocket ... Phenothiazines, Chlorides, Wikipedia medicine articles ready to translate, Dimethylamino compounds). ...
... , a phenothiazine derivative, is structurally different from the neuroleptic phenothiazines, with similar but ... Promethazine is in the phenothiazine family of medications. It is also a moderate anticholinergic, which produces its sedative ... another phenothiazine compound. Both promethazine and promazine exhibit comparable neuroleptic potency, with a neuroleptic ... Phenothiazines, Sodium channel blockers, Sigma receptor ligands, Wikipedia medicine articles ready to translate). ...
Succinyl choline, phenothiazines and tricyclic antidepressants causes trismus as a secondary effect. Trismus can be seen as an ... extra-pyramidal side-effect of metoclopromide, phenothiazines and other medications. Complications of radiotherapy: ...
Phenothiazines have been tested in vitro and in animal models of PAM. Improving case detection through increased awareness, ...
Antiemetics - Neuroleptic Class - Phenothiazines There are many other rare causes of torticollis. A very rare cause of acquired ...
Few pharmaceutically significant phenothiazines are prepared from phenothiazine, although some of them are. Phenothiazines are ... Phenothiazine is a prototypical pharmaceutical lead structure in medicinal chemistry. Phenothiazine itself is only of ... Phenothiazine was superseded by other drugs in the 1950s. The central C4SN ring is folded in phenothiazines. The compound was ... phenothiazine is often discussed as a prototypical example of a pharmaceutical lead structure. A number of phenothiazines other ...
This article discusses an overdose of phenothiazines. Overdose occurs when someone takes more than ... This article discusses an overdose of phenothiazines. Overdose occurs when someone takes more than ... Phenothiazines are medicines used to treat serious mental and emotional disorders, and to reduce nausea. ... Phenothiazines are medicines used to treat serious mental and emotional disorders, and to reduce nausea. ...
... -. Notes. *This display requires that Java be installed on your system and ...
... Molecular Formula: C18H21ClN2OS ... 2-CHLORO-10-(DIMETHYLAMINOETHOXYETHYL)PHENOTHIAZINE HYDROCHLORIDE 2-[2-(2-chlorophenothiazin-10-yl)ethoxy]-N,N-dimethyl- ...
Phenothiazines. Class Summary. These agents are effective in treating emesis, possibly owing to effects in the dopaminergic ...
Meanwhile, the steric effect of phenothiazine-based (,b ,PT1–3,/b,) dyes was also investigated. Dye with longer and ... Electrochemical and photochemical tests of phenothiazine dyes in solution and adsorbed on the TiO,sub ,2,/sub, surface showed ... The effects of dye-adsorption solvent on the performances of dye-sensitized solar cells based on phenothiazine dyes were ... and enhancing the overall cell performance because of the sterically hindered conformation of the phenothiazines. ...
Psychotherapeutic medications - phenothiazine derivatives. Phenothiazine derivative psychotherapeutic medications include:. * ...
10-(Chloroacetyl)-10H-phenothiazine. Change simulation parameters The result was obtained by a proprietary SIELC algorithm. It ... 10-(Chloroacetyl)-10H-phenothiazine can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile ... Separation of 10-(Chloroacetyl)-10H-phenothiazine on Newcrom R1 HPLC column. February 16, 2018. ...
The Neurologic Actions of Phenothiazine Compounds (Color, 16 Mm., 30 Minutes) . Produced by Smith Kline and French Laboratories ...
Phenothiazines emerged as the largest family of drugs that alter the autophagic process by increasing LC3-II punctae levels in ... Our studies highlight the potential role of phenothiazines as agents for combinational therapy with other chemotherapeutic ... In addition, we observed multiple biological effects in cancer cells treated with phenothiazines. Those antitumorigenic effects ... Phenothiazines emerged as the largest family of drugs that alter the autophagic process by increasing LC3-II punctae levels in ...
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IpIBA seminar series 2022/2023 "Antitumor effects of antipsychotic phenothiazines in glioblastoma cells". enero 17 @ 9:30 am - ... IpIBA seminar series 2022/2023 "Antitumor effects of antipsychotic phenothiazines in glioblastoma cells". *Inicio ... In the present in vitro study we tested the efficacy and the cellular effects of two antipsychotic phenothiazines ( ... IpIBA seminar series 2022/2023 "Antitumor effects of antipsychotic phenothiazines in glioblastoma cells" ...
Fluphenazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic ...
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Phenothiazines. Carbon monoxide. Lead. Cocaine. Mercury. Metabolic Abnormalities. Nutritional deficiencies (thiamine, selenium ...
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Phenothiazines (major tranquilizers, anti-emetics) - examples:. Acetophenazine. Butaperazine. Carphenazine. Chlorpromazine. ...
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phenothiazines*thyroid hormones, such as levothyroxine (Synthroid). *medications containing estrogens, such as:*hormone ...
phenothiazines. Dry mouth. Dry mouth, or xerostomia, can develop when the flow of saliva is not adequate. Most people with dry ...
Phenothiazine. TWA 5 mg/m 3 [skin]. Phenyl glycidyl ether. TWA 1 ppm (6 mg/m 3 ). ...
Drug classes: Phenothiazine antiemetics, Phenothiazine antipsychotics. Medically reviewed by Drugs.com. Last updated on Oct 22 ... Prochlorperazine is a propylpiperazine derivative of phenothiazine. Like other phenothiazines, it exerts an antiemetic effect ... with a phenothiazine should not receive any phenothiazine, including prochlorperazine, unless in the judgment of the physician ... Do not use in patients with known hypersensitivity to phenothiazines.. Do not use in comatose states or in the presence of ...
Basavaiah, K. and Srilatha and Swamy, J. M. and Krishnamurthy, G. (2000) Determination of some phenothiazine drugs based on ... phenothiazine drugs; determination; colour reaction; potassium periodate; spectrophotometry. Subjects:. C Chemical Science , ... The method is based on the formation of stable phenothiazine free radical by the use of potassium periodate as the chromogenic ... A simple, rapid and sensitive method for the determination of six phenothiazine drugs, either in pure form or in pharmaceutical ...
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local ...

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