Pharmacology: The study of the origin, nature, properties, and actions of drugs and their effects on living organisms.Pharmacology, Clinical: The branch of pharmacology that deals directly with the effectiveness and safety of drugs in humans.Drug Discovery: The process of finding chemicals for potential therapeutic use.International Agencies: International organizations which provide health-related or other cooperative services.Pharmacokinetics: Dynamic and kinetic mechanisms of exogenous chemical and DRUG LIBERATION; ABSORPTION; BIOLOGICAL TRANSPORT; TISSUE DISTRIBUTION; BIOTRANSFORMATION; elimination; and DRUG TOXICITY as a function of dosage, and rate of METABOLISM. LADMER, ADME and ADMET are abbreviations for liberation, absorption, distribution, metabolism, elimination, and toxicology.Pharmaceutical Preparations: Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Receptors, G-Protein-Coupled: The largest family of cell surface receptors involved in SIGNAL TRANSDUCTION. They share a common structure and signal through HETEROTRIMERIC G-PROTEINS.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Ligands: A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)Radioligand Assay: Quantitative determination of receptor (binding) proteins in body fluids or tissue using radioactively labeled binding reagents (e.g., antibodies, intracellular receptors, plasma binders).Societies, Pharmaceutical: Societies whose membership is limited to pharmacists.Drug Design: The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.Therapeutics: Procedures concerned with the remedial treatment or prevention of diseases.Webcasts as Topic: Transmission of live or pre-recorded audio or video content via connection or download from the INTERNET.Education, Pharmacy, Continuing: Educational programs designed to inform graduate pharmacists of recent advances in their particular field.Drug Evaluation, Preclinical: Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.History, 20th Century: Time period from 1901 through 2000 of the common era.Psychopharmacology: The study of the effects of drugs on mental and behavioral activity.Pharmacy Administration: The business and managerial aspects of pharmacy in its broadest sense.Drug-Related Side Effects and Adverse Reactions: Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.Pharmacogenetics: A branch of genetics which deals with the genetic variability in individual responses to drugs and drug metabolism (BIOTRANSFORMATION).Psychology, Experimental: The branch of psychology which seeks to learn more about the fundamental causes of behavior by studying various psychologic phenomena in controlled experimental situations.Receptors, GABA: Cell-surface proteins that bind GAMMA-AMINOBUTYRIC ACID with high affinity and trigger changes that influence the behavior of cells. GABA-A receptors control chloride channels formed by the receptor complex itself. They are blocked by bicuculline and usually have modulatory sites sensitive to benzodiazepines and barbiturates. GABA-B receptors act through G-proteins on several effector systems, are insensitive to bicuculline, and have a high affinity for L-baclofen.Neuropharmacology: The branch of pharmacology dealing especially with the action of drugs upon various parts of the nervous system.Receptors, GABA-A: Cell surface proteins which bind GAMMA-AMINOBUTYRIC ACID and contain an integral membrane chloride channel. Each receptor is assembled as a pentamer from a pool of at least 19 different possible subunits. The receptors belong to a superfamily that share a common CYSTEINE loop.Binding, Competitive: The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.CHO Cells: CELL LINE derived from the ovary of the Chinese hamster, Cricetulus griseus (CRICETULUS). The species is a favorite for cytogenetic studies because of its small chromosome number. The cell line has provided model systems for the study of genetic alterations in cultured mammalian cells.Drug Evaluation: Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Education, Pharmacy: Formal instruction, learning, or training in the preparation, dispensing, and proper utilization of drugs in the field of medicine.Receptors, Nicotinic: One of the two major classes of cholinergic receptors. Nicotinic receptors were originally distinguished by their preference for NICOTINE over MUSCARINE. They are generally divided into muscle-type and neuronal-type (previously ganglionic) based on pharmacology, and subunit composition of the receptors.Receptors, Serotonin: Cell-surface proteins that bind SEROTONIN and trigger intracellular changes which influence the behavior of cells. Several types of serotonin receptors have been recognized which differ in their pharmacology, molecular biology, and mode of action.Education, Medical, Undergraduate: The period of medical education in a medical school. In the United States it follows the baccalaureate degree and precedes the granting of the M.D.Clinical Trials as Topic: Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.Benzodiazepines: A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Problem-Based Learning: Instructional use of examples or cases to teach using problem-solving skills and critical thinking.Cardiovascular System: The HEART and the BLOOD VESSELS by which BLOOD is pumped and circulated through the body.Cricetinae: A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.Curriculum: A course of study offered by an educational institution.Piperidines: A family of hexahydropyridines.Half-Life: The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Allergy and Immunology: A medical specialty concerned with the hypersensitivity of the individual to foreign substances and protection from the resultant infection or disorder.Cannabinoids: Compounds having the cannabinoid structure. They were originally extracted from Cannabis sativa L. The most pharmacologically active constituents are TETRAHYDROCANNABINOL; CANNABINOL; and CANNABIDIOL.Drug Interactions: The action of a drug that may affect the activity, metabolism, or toxicity of another drug.Education, Pharmacy, Graduate: Educational programs for pharmacists who have a bachelor's degree or a Doctor of Pharmacy degree entering a specific field of pharmacy. They may lead to an advanced degree.Patch-Clamp Techniques: An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.Pharmacological Processes: The metabolism of drugs and their mechanisms of action.Receptors, Drug: Proteins that bind specific drugs with high affinity and trigger intracellular changes influencing the behavior of cells. Drug receptors are generally thought to be receptors for some endogenous substance not otherwise specified.Allosteric Regulation: The modification of the reactivity of ENZYMES by the binding of effectors to sites (ALLOSTERIC SITES) on the enzymes other than the substrate BINDING SITES.Piperoxan: A benzodioxane alpha-adrenergic blocking agent with considerable stimulatory action. It has been used to diagnose PHEOCHROMOCYTOMA and as an antihypertensive agent.Teaching: The educational process of instructing.Analgesics, Opioid: Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Guinea Pigs: A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.Toxicology: The science concerned with the detection, chemical composition, and biological action of toxic substances or poisons and the treatment and prevention of toxic manifestations.Drug Therapy: The use of DRUGS to treat a DISEASE or its symptoms. One example is the use of ANTINEOPLASTIC AGENTS to treat CANCER.Membrane Potentials: The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Pyridines: Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.GABA Agonists: Endogenous compounds and drugs that bind to and activate GAMMA-AMINOBUTYRIC ACID receptors (RECEPTORS, GABA).Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.Nobel PrizeIon Channel Gating: The opening and closing of ion channels due to a stimulus. The stimulus can be a change in membrane potential (voltage-gated), drugs or chemical transmitters (ligand-gated), or a mechanical deformation. Gating is thought to involve conformational changes of the ion channel which alters selective permeability.Mitragyna: A plant genus of the family RUBIACEAE. Members contain antimalarial (ANTIMALARIALS) and analgesic (ANALGESICS) indole alkaloids.Education, Professional: Formal education and training in preparation for the practice of a profession.Prostaglandins I: A class of cyclic prostaglandins that contain the 6,9-epoxy bond. Endogenous members of this family are biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES.Kinetics: The rate dynamics in chemical or physical systems.Injections, Intravenous: Injections made into a vein for therapeutic or experimental purposes.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Electrophysiology: The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.Nicotinic Antagonists: Drugs that bind to nicotinic cholinergic receptors (RECEPTORS, NICOTINIC) and block the actions of acetylcholine or cholinergic agonists. Nicotinic antagonists block synaptic transmission at autonomic ganglia, the skeletal neuromuscular junction, and at central nervous system nicotinic synapses.Receptors, Histamine H3: A class of histamine receptors discriminated by their pharmacology and mode of action. Histamine H3 receptors were first recognized as inhibitory autoreceptors on histamine-containing nerve terminals and have since been shown to regulate the release of several neurotransmitters in the central and peripheral nervous systems. (From Biochem Soc Trans 1992 Feb;20(1):122-5)History, 21st Century: Time period from 2001 through 2100 of the common era.History, 19th Century: Time period from 1801 through 1900 of the common era.Drug Delivery Systems: Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.Designer Drugs: Drugs designed and synthesized, often for illegal street use, by modification of existing drug structures (e.g., amphetamines). Of special interest are MPTP (a reverse ester of meperidine), MDA (3,4-methylenedioxyamphetamine), and MDMA (3,4-methylenedioxymethamphetamine). Many drugs act on the aminergic system, the physiologically active biogenic amines.GABA Modulators: Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here.History, 18th Century: Time period from 1701 through 1800 of the common era.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Hypnotics and Sedatives: Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.Serotonin Antagonists: Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.Receptors, Islet Amyloid Polypeptide: G-protein coupled receptors that are formed through the dimerization of the CALCITONIN RECEPTOR with a RECEPTOR ACTIVITY-MODIFYING PROTEIN. Their affinity for ISLET AMYLOID POLYPEPTIDE is dependent upon which of several receptor activity-modifying protein subtypes they are bound to.Cricetulus: A genus of the family Muridae consisting of eleven species. C. migratorius, the grey or Armenian hamster, and C. griseus, the Chinese hamster, are the two species used in biomedical research.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Nicotine: Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.Adrenergic alpha-1 Receptor Antagonists: Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS.GABA Antagonists: Drugs that bind to but do not activate GABA RECEPTORS, thereby blocking the actions of endogenous GAMMA-AMINOBUTYRIC ACID and GABA RECEPTOR AGONISTS.Education, Graduate: Studies beyond the bachelor's degree at an institution having graduate programs for the purpose of preparing for entrance into a specific field, and obtaining a higher degree.Dequalinium: A topical bacteriostat that is available as various salts. It is used in wound dressings and mouth infections and may also have antifungal action, but may cause skin ulceration.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Drug Partial Agonism: Drug agonism involving selective binding but reduced effect. This can result in some degree of DRUG ANTAGONISM.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Drug Industry: That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.Receptors, Cannabinoid: A class of G-protein-coupled receptors that are specific for CANNABINOIDS such as those derived from CANNABIS. They also bind a structurally distinct class of endogenous factors referred to as ENDOCANNABINOIDS. The receptor class may play a role in modulating the release of signaling molecules such as NEUROTRANSMITTERS and CYTOKINES.Strychnine: An alkaloid found in the seeds of STRYCHNOS NUX-VOMICA. It is a competitive antagonist at glycine receptors and thus a convulsant. It has been used as an analeptic, in the treatment of nonketotic hyperglycinemia and sleep apnea, and as a rat poison.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Bicyclo Compounds, Heterocyclic: A class of saturated compounds consisting of two rings only, having two or more atoms in common, containing at least one hetero atom, and that take the name of an open chain hydrocarbon containing the same total number of atoms. (From Riguady et al., Nomenclature of Organic Chemistry, 1979, p31)Potassium Channels: Cell membrane glycoproteins that are selectively permeable to potassium ions. At least eight major groups of K channels exist and they are made up of dozens of different subunits.Analgesics: Compounds capable of relieving pain without the loss of CONSCIOUSNESS.Picrotoxin: A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.PyridazinesReceptors, Histamine: Cell-surface proteins that bind histamine and trigger intracellular changes influencing the behavior of cells. Histamine receptors are widespread in the central nervous system and in peripheral tissues. Three types have been recognized and designated H1, H2, and H3. They differ in pharmacology, distribution, and mode of action.Pregnanediones: Pregnane derivatives in which two side-chain methyl groups or two methylene groups in the ring skeleton (or a combination thereof) have been oxidized to keto groups.Central Nervous System: The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.Histamine Antagonists: Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only.HEK293 Cells: A cell line generated from human embryonic kidney cells that were transformed with human adenovirus type 5.Nicotinic Agonists: Drugs that bind to and activate nicotinic cholinergic receptors (RECEPTORS, NICOTINIC). Nicotinic agonists act at postganglionic nicotinic receptors, at neuroeffector junctions in the peripheral nervous system, and at nicotinic receptors in the central nervous system. Agents that function as neuromuscular depolarizing blocking agents are included here because they activate nicotinic receptors, although they are used clinically to block nicotinic transmission.Research Personnel: Those individuals engaged in research.Xenopus laevis: The commonest and widest ranging species of the clawed "frog" (Xenopus) in Africa. This species is used extensively in research. There is now a significant population in California derived from escaped laboratory animals.Serotonin: A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Receptors, Opioid: Cell membrane proteins that bind opioids and trigger intracellular changes which influence the behavior of cells. The endogenous ligands for opioid receptors in mammals include three families of peptides, the enkephalins, endorphins, and dynorphins. The receptor classes include mu, delta, and kappa receptors. Sigma receptors bind several psychoactive substances, including certain opioids, but their endogenous ligands are not known.Sulfonamides: A group of compounds that contain the structure SO2NH2.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Membrane Transport Modulators: Agents that affect ION PUMPS; ION CHANNELS; ABC TRANSPORTERS; and other MEMBRANE TRANSPORT PROTEINS.Protein Subunits: Single chains of amino acids that are the units of multimeric PROTEINS. Multimeric proteins can be composed of identical or non-identical subunits. One or more monomeric subunits may compose a protomer which itself is a subunit structure of a larger assembly.Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.Receptors, Calcitonin: Cell surface proteins that bind calcitonin and trigger intracellular changes which influence the behavior of cells. Calcitonin receptors outside the nervous system mediate the role of calcitonin in calcium homeostasis. The role of calcitonin receptors in the brain is not well understood.Acetylcholine: A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.Potassium Channel Blockers: A class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of ACTION POTENTIALS. They are used as ANTI-ARRHYTHMIA AGENTS and VASODILATOR AGENTS.Systems Biology: Comprehensive, methodical analysis of complex biological systems by monitoring responses to perturbations of biological processes. Large scale, computerized collection and analysis of the data are used to develop and test models of biological systems.Nerium: A plant genus of the family APOCYNACEAE. It is a very poisonous plant that contains cardioactive agents.Behavior, Animal: The observable response an animal makes to any situation.Biological Availability: The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.Serotonin Receptor Agonists: Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS.Neuromuscular Blocking Agents: Drugs that interrupt transmission of nerve impulses at the skeletal neuromuscular junction. They can be of two types, competitive, stabilizing blockers (NEUROMUSCULAR NONDEPOLARIZING AGENTS) or noncompetitive, depolarizing agents (NEUROMUSCULAR DEPOLARIZING AGENTS). Both prevent acetylcholine from triggering the muscle contraction and they are used as anesthesia adjuvants, as relaxants during electroshock, in convulsive states, etc.Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.Inhibitory Concentration 50: The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Central Nervous System Agents: A class of drugs producing both physiological and psychological effects through a variety of mechanisms. They can be divided into "specific" agents, e.g., affecting an identifiable molecular mechanism unique to target cells bearing receptors for that agent, and "nonspecific" agents, those producing effects on different target cells and acting by diverse molecular mechanisms. Those with nonspecific mechanisms are generally further classed according to whether they produce behavioral depression or stimulation. Those with specific mechanisms are classed by locus of action or specific therapeutic use. (From Gilman AG, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p252)QuinolizinesMecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.Calcium Channel Blockers: A class of drugs that act by selective inhibition of calcium influx through cellular membranes.Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.Synaptic Transmission: The communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES.Synephrine: Sympathetic alpha-adrenergic agonist with actions like PHENYLEPHRINE. It is used as a vasoconstrictor in circulatory failure, asthma, nasal congestion, and glaucoma.Ascaris suum: A species of parasitic nematode usually found in domestic pigs and a few other animals. Human infection can also occur, presumably as result of handling pig manure, and can lead to intestinal obstruction.Tissue Distribution: Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.Receptors, Adrenergic, alpha-1: A subclass of alpha-adrenergic receptors that mediate contraction of SMOOTH MUSCLE in a variety of tissues such as ARTERIOLES; VEINS; and the UTERUS. They are usually found on postsynaptic membranes and signal through GQ-G11 G-PROTEINS.Conotoxins: Peptide neurotoxins from the marine fish-hunting snails of the genus CONUS. They contain 13 to 29 amino acids which are strongly basic and are highly cross-linked by disulfide bonds. There are three types of conotoxins, omega-, alpha-, and mu-. OMEGA-CONOTOXINS inhibit voltage-activated entry of calcium into the presynaptic membrane and therefore the release of ACETYLCHOLINE. Alpha-conotoxins inhibit the postsynaptic acetylcholine receptor. Mu-conotoxins prevent the generation of muscle action potentials. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)Hallucinogens: Drugs capable of inducing illusions, hallucinations, delusions, paranoid ideations, and other alterations of mood and thinking. Despite the name, the feature that distinguishes these agents from other classes of drugs is their capacity to induce states of altered perception, thought, and feeling that are not experienced otherwise.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Dopamine: One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.Organizational Affiliation: Formal relationships established between otherwise independent organizations. These include affiliation agreements, interlocking boards, common controls, hospital medical school affiliations, etc.Oocytes: Female germ cells derived from OOGONIA and termed OOCYTES when they enter MEIOSIS. The primary oocytes begin meiosis but are arrested at the diplotene state until OVULATION at PUBERTY to give rise to haploid secondary oocytes or ova (OVUM).Receptor, Cannabinoid, CB1: A subclass of cannabinoid receptor found primarily on central and peripheral NEURONS where it may play a role modulating NEUROTRANSMITTER release.Cholinergic Agents: Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of ACETYLCHOLINE, and drugs that affect the survival of cholinergic neurons. The term cholinergic agents is sometimes still used in the narrower sense of MUSCARINIC AGONISTS, although most modern texts discourage that usage.Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.Animal Rights: The moral and ethical bases of the protection of animals from cruelty and abuse. The rights are extended to domestic animals, laboratory animals, and wild animals.Receptors, Opioid, mu: A class of opioid receptors recognized by its pharmacological profile. Mu opioid receptors bind, in decreasing order of affinity, endorphins, dynorphins, met-enkephalin, and leu-enkephalin. They have also been shown to be molecular receptors for morphine.Computer-Assisted Instruction: A self-learning technique, usually online, involving interaction of the student with programmed instructional materials.Adrenergic beta-3 Receptor Antagonists: Drugs that bind to and block the activation of ADRENERGIC BETA-3 RECEPTORS.Adrenergic alpha-1 Receptor Agonists: Compounds that bind to and activate ADRENERGIC ALPHA-1 RECEPTORS.Receptors, Dopamine: Cell-surface proteins that bind dopamine with high affinity and trigger intracellular changes influencing the behavior of cells.Pharmaceutical Preparations, Dental: Drugs intended for DENTISTRY.Leukemia L1210Receptors, Bombesin: Cell surface proteins that bind bombesin or closely related peptides with high affinity and trigger intracellular changes influencing the behavior of cells. Gastrin- releasing peptide (GRP); GRP 18-27 (neuromedin C), and neuromedin B are endogenous ligands of bombesin receptors in mammals.Crotonates: Derivatives of BUTYRIC ACID that include a double bond between carbon 2 and 3 of the aliphatic structure. Included under this heading are a broad variety of acid forms, salts, esters, and amides that include the aminobutryrate structure.Neurosciences: The scientific disciplines concerned with the embryology, anatomy, physiology, biochemistry, pharmacology, etc., of the nervous system.Biotransformation: The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.Receptors, Dopamine D2: A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLYL CYCLASES.IndianaTransfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.GABA-A Receptor Agonists: Endogenous compounds and drugs that bind to and activate GABA-A RECEPTORS.Great BritainCarubicin: A very toxic anthracycline-type antineoplastic related to DAUNORUBICIN, obtained from Actinomadura carminata.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Molecular Targeted Therapy: Treatments with drugs which interact with or block synthesis of specific cellular components characteristic of the individual's disease in order to stop or interrupt the specific biochemical dysfunction involved in progression of the disease.Tubocurarine: A neuromuscular blocker and active ingredient in CURARE; plant based alkaloid of Menispermaceae.Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.PiperazinesStudents, Nursing: Individuals enrolled in a school of nursing or a formal educational program leading to a degree in nursing.Trientine: An ethylenediamine derivative used as stabilizer for EPOXY RESINS, as ampholyte for ISOELECTRIC FOCUSING and as chelating agent for copper in HEPATOLENTICULAR DEGENERATION.Spider Venoms: Venoms of arthropods of the order Araneida of the ARACHNIDA. The venoms usually contain several protein fractions, including ENZYMES, hemolytic, neurolytic, and other TOXINS, BIOLOGICAL.Phenethylamines: A group of compounds that are derivatives of beta- aminoethylbenzene which is structurally and pharmacologically related to amphetamine. (From Merck Index, 11th ed)OxadiazolesHerb-Drug Interactions: The effect of herbs, other PLANTS, or PLANT EXTRACTS on the activity, metabolism, or toxicity of drugs.Geriatrics: The branch of medicine concerned with the physiological and pathological aspects of the aged, including the clinical problems of senescence and senility.Adrenergic alpha-Antagonists: Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.ThiadiazolesEducational Measurement: The assessing of academic or educational achievement. It includes all aspects of testing and test construction.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Histamine Agonists: Drugs that bind to and activate histamine receptors. Although they have been suggested for a variety of clinical applications histamine agonists have so far been more widely used in research than therapeutically.Receptors, Neuropeptide: Cell surface receptors that bind specific neuropeptides with high affinity and trigger intracellular changes influencing the behavior of cells. Many neuropeptides are also hormones outside of the nervous system.Adrenergic Antagonists: Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE.Atropine: An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isomer of atropine.Lysergic Acid Diethylamide: Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is a potent hallucinogen, but the mechanisms of that effect are not well understood.Sisomicin: Antibiotic produced by Micromonospora inyoensis. It is closely related to gentamicin C1A, one of the components of the gentamicin complex (GENTAMICINS).Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Parasympathomimetics: Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here.Cannabinoid Receptor Agonists: Compounds that interact with and stimulate the activity of CANNABINOID RECEPTORS.Calcium Channels: Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorized as L-, T-, N-, P-, Q-, and R-types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. The L- and T-types are present throughout the cardiovascular and central nervous systems and the N-, P-, Q-, & R-types are located in neuronal tissue.Isoquinolines: A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids such as papaverine. (From Stedman, 25th ed)Pyrazoles: Azoles of two nitrogens at the 1,2 positions, next to each other, in contrast with IMIDAZOLES in which they are at the 1,3 positions.

*  Quantitative pharmacology
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*  Pharmacology
... Nutrition Components of Pharmacology. In the Pharmacology course, several areas relevant to nutrition are covered, such as lipids, diabetes mellitus, and gastrointestinal disease. Students will be able to use their knowledge of nutrition from the 1st year course to integrate dietary interventions with drug treatment options. Lecture content directly relevant to nutrition:. Antihyperlipidemic drugs Nausea, vomiting and antiemetic therapy Drugs affecting the gastrointestinal tract Retinoidsand vitamin D analogs Insulin and oral hypoglycemic drugs Therapeutics of disorders in calcium metabolism.
http://columbia.edu/itc/hs/medical/nutrition/yr_02/pharmacology.html
*  Newest 'pharmacology' Questions - Biology Stack Exchange
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*  Pulmonary Pharmacology
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*  European Journal of Clinical Pharmacology Volume 16 Issue 5 | DeepDyve
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*  European Association for Clinical Pharmacology and Therapeutics
... {{Infobox organization name = European Association for Clinical Pharmacology and Therapeutics logo = File:EACPT Organization logo.png. dissolved = footnotes = }} The 'European Association for Clinical Pharmacology and Therapeutics' EACPT is a learned society in the field of clinical pharmacology. 1 At that congress the founding EACPT Council elected an Executive Committee with Sjöqvist as chairman, Michael Orme United Kingdom as Honorary Secretary, Jochen Kuhlmann Germany as Treasurer, and Giampaolo Velo Italy as Vice-Chairman, with 26 European countries as members through their home country clinical pharmacology society or section. 2 The EACPT now includes all national organisations for clinical pharmacology in Europe and provides educational and scientific support for the more than 4000 individual professionals interested in clinical pharmacology and therapeutics throughout the European region, with its congresses attended by a global audience. Aims Activities ...
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*  Basic and Clinical Pharmacology 1st Edition | 9780838505625 | eCampus.com
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*  Clinical Pharmacologists near Charlestown, MA
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*  JHU Clinical Pharmacology - Overview
... The Division of Clinical Pharmacology at the Johns Hopkins University School of Medicine is part of both the Department of Medicine and of the Department of Pharmacology and Molecular Sciences. An endowment made in 1971 by the Burroughs Wellcome Fund established the Wellcome Professorship and the annual Sir Henry Dale Lecture. Past directors of the Division include Louis Lasagna whose research on the quantitative measurement of pain and the importance of the placebo were seminal; Pedro Cuatrecasas, best known for his discovery of the insulin receptor; and Paul Lietman whose deep interest in anti-infective agents molded the careers of the current faculty. Since 2001 the Division has been directed by Theresa Shapiro, whose interests include the discovery and development of new treatments for malaria and other parasitic infections. Though each faculty member has an individual research program, sometimes with a substantial molecular laboratory component, all clinical studies are conducted in ...
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*  American College of Clinical Pharmacology
... {{Infobox Organization name = American College of Clinical Pharmacology image = image border = size = 150px caption = membership = |budget = |abbreviation = ACCP formation = 1969 headquarters = Ashburn, Virginia |leader title = leader name = website = }} The 'American College of Clinical Pharmacology' 'ACCP' is a national organization of clinical pharmacology healthcare professionals who seek to advance clinical pharmacology. 1 History and mission Structure Membership Publications Activities Education and information resources References External links. History and mission. In the 1960s, a group of physicians formulated the concept of an organization dedicated to a new branch of pharmacology that dealt with the effectiveness and safety of drugs in humans. As a result of their efforts, the American College of Clinical Pharmacology ACCP was founded on September 11, 1969. 2 The mission is to improve health by optimizing therapeutics and to provide leadership and ...
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*  Clinical Pharmacologists near Boulder, CO
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*  British Journal of Clinical Pharmacology - Society Information - Wiley Online Library
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*  EACPT | European Association for Clinical Pharmacology and Therapeutics
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*  International Union of Basic and Clinical Pharmacology
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https://en.wikipedia.org/wiki/International_Union_of_Basic_and_Clinical_Pharmacology
*  Clinical Pharmacology | 978-0-7020-4084-9 | Elsevier
Clinical Pharmacology. Elsevier. Clinical Pharmacology By Peter Bennett, MD FRCP DPMSA, Formerly Reader in Clinical Pharmacology, University of Bath, and Consultant Physician, Royal United Hospital, Bath, UK Morris Brown, MA MSc FRCP FAHA FMedSci, Professor of Clinical Pharmacology, University of Cambridge; Consultant Physician, Addenbrooke's Hospital, Cambridge; and Director of Clinical Studies, Gonville and Caius College, University of Cambridge, Cambridge, UK Pankaj Sharma, MD PhD FRCP, Reader in Clinical Neurology at Imperial College London; Consultant Neurologist at Hammersmith Hospitals, London, UK A thorough knowledge of pharmacological and therapeutic principles is vital if drugs are to be used safely and effectively for increasingly informed patients. Those who clearly understand how drugs get into the body, how they produce their effects, what happens to them in the body, and how evidence of their therapeutic effect is assessed, will choose drugs more skilfully, and use ...
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*  Clinical Pharmacology & Experimental Therapeutics Center
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*  Phone & Address for Dr. Ralph Miech, MD - Clinical Pharmacology & Emergency Medicine - Riverside, RI
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*  Fox Chase Cancer Center : Fox Chase Names Anthony J. Olszanski Director of Clinical Pharmacology for
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*  Hypertension and Clinical Pharmacology | Baylor College of Medicine | Houston, Texas
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*  Cantil (Mepenzolate Bromide) Drug Information: Clinical Pharmacology - Prescribing Information at Rx
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*  Aminohippurate Sodium (Aminohippurate) Drug Information: Clinical Pharmacology - Prescribing Informa
Aminohippurate Sodium Aminohippurate Drug Information: Clinical Pharmacology - Prescribing Information at RxList. Pill Identifier Search. Drugs A-Z. Pill Identifier. Supplements. Slideshows. Images. Symptom Checker. Diseases. Dictionary. Quizzes. drugs a-z list. aminohippurate sodium aminohippurate side effects drug center. aminohippurate sodium aminohippurate drug - clinical pharmacology. Read the 100 Top Drugs Through June article. Aminohippurate Sodium. Constipation Myths and Facts Slideshow. Drug Description. CLINICAL PHARMACOLOGY PAH is filtered by the glomeruli and is actively secreted by the proximal tubules. Inulin clearance is generally measured during TmPAH determinations since glomerular filtration rate GFR must be known before calculations of secretory Tm measurements can be done see DOSAGE AND ADMINISTRATION, Calculations. Next: Drug Description. Aminohippurate Sodium FDA Prescribing Information Drug Description. Side Effects Drug Interactions. Overdosage Contraindications. ...
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*  In a despicable way Crossword Clue, Crossword Solver | Wordplays.com
In a despicable way Crossword Clue, Crossword Solver. Wordplays.com. Scrabble Cheat, Scrabble Help, Word Finder, Crossword Solver. Site Search. Site Search. Dictionary. Word Finder. sign in. Crossword Solver,Scrabble Cheat, Scrabble Help, Word Finder. Crossword Solver. Word Finder. Boggle. Text Twist. Sudoku. Anagram Solver. Word Games. Help. Words with Friends Cheat. Word Jumbles. Word Search. Full Board Cheat. Cryptogram. Crossword Solver Help Help. Crossword Solver. The Crossword Solver found answers to the In-a-despicable-way crossword clue. The Crossword Solver will often find clues used in the New York Times Crossword, USA Today Crossword, LA Times Crossword, The Guardian, the Daily Mirror, the Telegraph crosswords and many other popular crossword puzzles. Enter the length or part of the answer to get a better match. Click on the answer to find other similar crossword clues. Use the Crossword Solver to find answers to crossword puzzle clues. Enter a Crossword Clue. A clue is required. # of Letters or ...
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*  Madman? Crossword Clue, Crossword Solver | Wordplays.com
Madman. Crossword Clue, Crossword Solver. Wordplays.com. Scrabble Cheat, Scrabble Help, Word Finder, Crossword Solver. Site Search. Site Search. Dictionary. Word Finder. sign in. . Crossword Solver,Scrabble Cheat, Scrabble Help, Word Finder. Crossword Solver. Word Finder. Boggle. Text Twist. Sudoku. Anagram Solver. Word Games. . Help. Words with Friends Cheat. Words in Words. Word Jumbles. Word Search. Full Board Cheat. Cryptogram. . Crossword Solver Help Help. Crossword Solver. The Crossword Solver found answers to the Madman. crossword clue. The Crossword Solver will often find clues used in the New York Times Crossword, USA Today Crossword, LA Times Crossword, The Guardian, the Daily Mirror, the Telegraph crosswords and many other popular crossword puzzles. Enter the length or part of the answer to get a better match. Click on the answer to find other similar crossword clues. Use the Crossword Solver to find answers to crossword puzzle clues. Enter a Crossword Clue. A clue is required. # of Letters or ...
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*  Crossword Puzzles by Brendan Emmett Quigley: CROSSWORD #389: Raising Your Spirits
... Crossword Puzzles by Brendan Emmett Quigley. December 01, 2011 CROSSWORD #389: Raising Your Spirits CROSSWORD SOLVER PUZZLE: PROGRAM: PROGRAM: PRINTOUT PUZZLE: PROGRAM: ACROSS LITE PUZZLE: PROGRAM:. You gotta love the little things in life. Believe me, I love the little things in a crossword constructor's life. Yes, Tabitha does qualify a "little thing," and yes, I love her to bits. But the "little things" I was referring to are those miracle answers. The answer that is so amazing that it was hard to believe that it wasn't the one that started things off. And when those answers appear, you can hear the voices of the crossword gods saying: "yea, verily, this puzzle shall come to pass," or something. I don't always hear the crossword gods talking to me. My pleas of "Are you there, crossword gods. CROSSWORD #389: Raising Your Spirits CROSSWORD SOLVER PUZZLE: PROGRAM: PROGRAM: PRINTOUT PUZZLE: PROGRAM: ACROSS LITE PUZZLE: PROGRAM:. You gotta love the little things in life. Believe me, I love the little ...
http://brendanemmettquigley.com/2011/12/crossword-389-raising-your-spirits.html
*  Disease models and clinical pharmacology events
... UCL Home. Prospective students. Current students. Staff. skip to navigation. skip to content. UCL School of Pharmacy. UCL Home. UCL School of Pharmacy. Disease models and clinical pharmacology events. About. Departments. People. Courses. Current Students. Research. Facilities. News. Staff Intranet. Alumni. Pharmacy Home. UCL School of Pharmacy Home. About. Departments. People. Courses. Current Students. Research. Facilities. News. Staff Intranet. Pharmacy News Publication. Pharmacy Events Publication. Alumni. News and events. Events. Behavioural medicine and treatment optimisation events. Biodiversity and medicines events. Disease models and clinical pharmacology events. Drug discovery events. Global workforce and education events. Molecular drug delivery and nanomedicine events. Neuroscience in health & disease events. Pharmaceutical materials and dosage form design events. Projects. CDT Old Events. Disease models and clinical pharmacology events. UCL Researchers presenting at ...
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*  Clinical Pharmacology & Therapeutics
clinical pharmacology therapeutics clinical pharmacology therapeutics clinical pharmacology therapeutics is a monthly peer reviewed medical journal which covers research on the nature action efficacy and evaluation of therapeutics the editor in chief is scott waldman thomas jefferson university the journal was established in and is published by wiley blackwell it is the official journal of the american society for clinical pharmacology therapeutics abstracting and indexing the journal is abstracted and indexed in chemical abstracts service current contents clinical medicine current contents life sciences biosis previews ebsco databases index medicus medline pubmed science citation index scopus according to the journal citation reports the journal has a impact factor of ranking it th out of journals in the category pharmacology pharmacy references external links category pharmacology journals category monthly journals category wiley blackwell academic journals ...
https://en.wikipedia.org/wiki/Clinical_Pharmacology_&_Therapeutics
*  Sagent Pharmaceuticals Inc Selects ProspectoRx and Clinical Pharmacology
... Employer:. Login. Post Jobs. Job Seeker:. Login. Sign Up. Home. News. Jobs. Career Resources. Hotbeds. Career Fairs. Events. Company Profiles. Investors. Search Life Sciences Jobs. Search Job Title Only. Radius: Miles. Km 80.5. News. News By Subject. News by Disease. News By Date. Search News. Get Our FREE Industry eNewsletter email:. Sagent Pharmaceuticals, Inc. Selects ProspectoRx and Clinical Pharmacology. Tweet. 3/14/2013 10:10:22 AM AMPA, Florida, March 14, 2013 — /PRNewswire/ -- Elsevier's Gold Standard solutions chosen to provide current, accurate drug data and pricing Elsevier's Gold Standard, a leading drug information provider, announced today that Sagent Pharmaceuticals, a specialty pharmaceutical company focused on developing, manufacturing, sourcing and marketing pharmaceutical products, with a specific emphasis on injectables, has selected ProspectoRx and Clinical Pharmacology to access current and accurate drug data and pricing. Sagent Pharmaceuticals offers an extensive ...
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*  3rd International Workshop on Clinical Pharmacology of Hepatitis Therapy - Clinical Pharmacology Con
... ference. News. View All. View All. Complementary Medicine. Drugs and Therapeutics. Health News. Weight Issues. All Speciality Acupuncture AIDS/HIV Allergy Alternative medicine Anesthesiology Asthma Cancer Surgery Cardiac Pacing and Electrophysiology Cardiology Chiropractics Clinical Neuropharmacology Clinical Pharmacology Colo-Rectal Cornea and Refractive Surgery Critical Care Medicine Dental Dermatology Diabetology Emergency medicine Endocrinology ENT Epidemiology Gastroenterology General Medicine General-Practice Genetics Geriatrics Gynaec-Urology Hematology Hepatic and Biliary Disorders Holistic Healing Hospital Administration Immunology Infectious diseases Intensive care Internal Medicine Laparoscopic Medical Education Medical Information Medicine Microbiology Miscellaneous Nephrology Neurology Neuropharmacology NeuroSurgery Nutrition/Dietetics Obstetrics & Gynecology Oncology Ophthalmology Oral Cancer Organ Transplantation Organising Secretary Orthopedics Osteoporosis Others ...
http://medindia.net/medical-conference/3rd-International-Workshop-on-Clinical-Pharmacology-of-Hepatitis-Therapy-New-Orleans-United-States-9-4-2008-2873.htm
*  Vladimir Patras Blog: Clinical Pharmacology Seminars Presentations
vladimir patras blog clinical pharmacology seminars presentations vladimir patras blog monday november clinical pharmacology seminars presentations clinical pharmacology seminars presentations to which i am about to give lectures at faculty of pharmacy comenius university in this november and december are here to download over the counter otc drugs pharmacovigilance zverejnil vlado patras o pm email this blogthis share to twitter share to facebook share to pinterest comments dissertation said whenever i see the post like your s i feel that there are still helpful people who share information for the help of others it must be helpful for other s thanx and good job finance dissertation proposal may at pm jeeny said i have been visiting various blogs for my mba assignment research i have found your blog to be quite useful keep updating your blog with valuable information regards october at am kass pasok said this comment has been removed by a blog administrator march at pm post a comment ...
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*  Betimol (Timolol Ophthalmic Solution) Drug Information: Clinical Pharmacology - Prescribing Informat
Betimol Timolol Ophthalmic Solution Drug Information: Clinical Pharmacology - Prescribing Information at RxList. Pill Identifier Search. Drugs A-Z. Pill Identifier. Images. Dictionary. drugs a-z list. betimol timolol ophthalmic solution side effects drug center. betimol timolol ophthalmic solution drug - clinical pharmacology. Mechanism That Allows Bacteria to Infect Plants May Inspire Cure for Eye Disease "By borrowing a tool from bacteria that infect plants, scientists have developed a new approach to eliminate mutated DNA inside mitochondria the energy factories within cells. Read the Mechanism That Allows Bacteria to Infect Plants May Inspire Cure for Eye Disease article. Betimol. Eye Diseases and Conditions Slideshow Pictures. Pink Eye Slideshow Pictures. Laser Eye Surgery Slideshow Pictures. Drug Description Patient Information. CLINICAL PHARMACOLOGY Timolol is a non-selective beta-adrenergic antagonist. In general, beta-adrenergic blocking agents reduce cardiac output both in ...
http://rxlist.com/betimol-drug/clinical-pharmacology.htm
*  Nordette-28 (Levonorgestrel and Ethinyl Estradiol Tablets) Drug Information: Clinical Pharmacology -
Nordette-28 Levonorgestrel and Ethinyl Estradiol Tablets Drug Information: Clinical Pharmacology - Prescribing Information at RxList. Pill Identifier Search. Drugs A-Z. Pill Identifier. Supplements. Slideshows. Images. Symptom Checker. Diseases. Dictionary. Quizzes. drugs a-z list. nordette-28 levonorgestrel and ethinyl estradiol tablets side effects drug center. nordette-28 levonorgestrel and ethinyl estradiol tablets drug - clinical pharmacology. Plan B One-Step Emergency Contraceptive Approved for 15 and Older "The U.S. Food and Drug Administration today announced that it has approved an amended application submitted by Teva Women's Health, Inc. to market Plan B One-Step active ingredient levonorgestrel for use without a prescription by women 15 years"... Read the Plan B One-Step Emergency Contraceptive Approved for 15 and Older article. Previous. Nordette-28. Birth Control Slideshow Pictures. Drug Description. Previous. Next: Drug Description. Nordette-28 FDA Prescribing Information Drug ...
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*  Azasite (Azithromycin Ophthalmic) - Description and Clinical Pharmacology
Azasite Azithromycin Ophthalmic - Description and Clinical Pharmacology. Rx drug information, pharmaceutical research, clinical trials, news, and more. Drugs By Name By Condition By Category Most Searched Ratings/Reviews Adverse Events Actives. Azasite Azithromycin Ophthalmic - Description and Clinical Pharmacology. Azasite Rx. Summary Description and Clinical Pharmacology Indications and Dosage Warnings and Precautions Side Effects and Adverse Reactions Drug Interactions, Overdosage, Contraindications, Other Rx Info Side Effect Reports. Azasite News. Published Studies Curr't Clinical Trials. DESCRIPTION. AzaSite azithromycin ophthalmic solution is a 1% sterile aqueous topical ophthalmic solution of azithromycin formulated in DuraSite ® polycarbophil, edetate disodium, sodium chloride. AzaSite is an off-white, viscous liquid with an osmolality of approximately 290 mOsm/kg. Preservative: 0.003% benzalkonium chloride. Inactives: mannitol, citric acid, sodium citrate, poloxamer 407, ...
http://druglib.com/druginfo/azasite/description_pharmacology/
*  Depacon (Valproate) - Description and Clinical Pharmacology
Depacon Valproate - Description and Clinical Pharmacology. Rx drug information, pharmaceutical research, clinical trials, news, and more. Drugs By Name By Condition By Category Most Searched Ratings/Reviews Adverse Events Actives. Depacon Valproate Sodium - Description and Clinical Pharmacology. Depacon Rx. Summary Description and Clinical Pharmacology Indications and Dosage Warnings and Precautions Side Effects and Adverse Reactions Drug Interactions, Overdosage, Contraindications, Other Rx Info Side Effect Reports. Depacon News. News in Media Published Studies Curr't Clinical Trials. DESCRIPTION. Valproate sodium is the sodium salt of valproic acid designated as sodium 2-propylpentanoate. Valproate sodium has the following structure: Valproate sodium has a molecular weight of 166.2. It occurs as an essentially white and odorless, crystalline, deliquescent powder. DEPACON solution is available in 5 mL single-dose vials for intravenous injection. Each mL contains valproate sodium ...
http://druglib.com/druginfo/depacon/description_pharmacology/
*  Amevive (Alefacept) - Description and Clinical Pharmacology
Amevive Alefacept - Description and Clinical Pharmacology. Rx drug information, pharmaceutical research, clinical trials, news, and more. Drugs By Name By Condition By Category Most Searched Ratings/Reviews Adverse Events Actives. Amevive Alefacept - Description and Clinical Pharmacology. Amevive Rx. Summary Description and Clinical Pharmacology Indications and Dosage Warnings and Precautions Side Effects and Adverse Reactions Drug Interactions, Overdosage, Contraindications, Other Rx Info Active Ingredients Side Effect Reports. Amevive News. News in Media Published Studies Curr't Clinical Trials. DESCRIPTION. AMEVIVE. alefacept is an immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 LFA-3 linked to the Fc hinge, C H 2 and C H 3 domains portion of human IgG1. Alefacept is produced by recombinant DNA technology in a Chinese Hamster Ovary CHO mammalian cell expression system. The molecular weight of ...
http://druglib.com/druginfo/amevive/description_pharmacology/
*  Amikacin - Description and Clinical Pharmacology
... Rx drug information, pharmaceutical research, clinical trials, news, and more. Drugs By Name By Condition By Category Most Searched Ratings/Reviews Adverse Events Actives. Amikacin Amikacin Sulfate - Description and Clinical Pharmacology. Amikacin Rx. Summary Description and Clinical Pharmacology Indications and Dosage Warnings and Precautions Side Effects and Adverse Reactions Drug Interactions, Overdosage, Contraindications, Other Rx Info Active Ingredients Side Effect Reports. Amikacin News. Published Studies Curr't Clinical Trials. To reduce the development of drug-resistant bacteria and maintain the effectiveness of amikacin sulfate injection USP and other antibacterial drugs, amikacin sulfate injection USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. DESCRIPTION. Amikacin Sulfate Injection USP is a semi-synthetic aminoglycoside antibiotic derived from kanamycin. D-Streptamine, O -3-amino-3-deoxy- -D-glucopyranosyl- ...
http://druglib.com/druginfo/amikacin/description_pharmacology/
*  Propine (Dipivefrin) Drug Information: Clinical Pharmacology - Prescribing Information at RxList
Propine Dipivefrin Drug Information: Clinical Pharmacology - Prescribing Information at RxList. Pill Identifier Search. Drugs A-Z. Pill Identifier. Symptom Checker. propine dipivefrin side effects drug center. propine dipivefrin drug - clinical pharmacology. iPads May Help Those With 'Low Vision' Read Better "Nov. Read the iPads May Help Those With 'Low Vision' Read Better article. Propine. Eye Diseases and Conditions Slideshow Pictures. Pink Eye Slideshow Pictures. Laser Eye Surgery Slideshow Pictures. CLINICAL PHARMACOLOGY PROPINE dipivefrin HCI ophthalmic solution, USP is a member of a class of drugs known as prodrugs. PROPINE dipivefrin ophthalmic solution is a prodrug of epinephrine formed by the diesterification of epinephrine and pivalic acid. PROPINE dipivefrin is converted to epinephrine inside the human eye by enzyme hydrolysis. The PROPINE dipivefrin prodrug delivery system is a more efficient way of delivering the therapeutic effects of epinephrine, with fewer side effects ...
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*  Plasbumin-5 (Albumin) - Description and Clinical Pharmacology
Plasbumin-5 Albumin - Description and Clinical Pharmacology. Rx drug information, pharmaceutical research, clinical trials, news, and more. Drugs By Name By Condition By Category Most Searched Ratings/Reviews Adverse Events Actives. Plasbumin-5 Albumin - Description and Clinical Pharmacology. Plasbumin-5 Rx. Summary Description and Clinical Pharmacology Indications and Dosage Warnings and Precautions Side Effects and Adverse Reactions Drug Interactions, Overdosage, Contraindications, Other Rx Info Side Effect Reports. News Research. News in Media Published Studies Curr't Clinical Trials. DESCRIPTION. Albumin Human 5%, USP Plasbumin -5 is made from pooled human venous plasma using the Cohn cold ethanol fractionation process. Part of the fractionation may be performed by another licensed manufacturer. It is prepared in accordance with the applicable requirements established by the U.S. Food and Drug Administration. Plasbumin-5 is a 5% sterile solution of albumin in an aqueous diluent. The ...
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*  Strattera (Atomoxetine) - Description and Clinical Pharmacology
Strattera Atomoxetine - Description and Clinical Pharmacology. Rx drug information, pharmaceutical research, clinical trials, news, and more. Drugs By Name By Condition By Category Most Searched Ratings/Reviews Adverse Events Actives. Strattera Atomoxetine Hydrochloride - Description and Clinical Pharmacology. Strattera Rx. Summary Description and Clinical Pharmacology Indications and Dosage Warnings and Precautions Side Effects and Adverse Reactions Drug Interactions, Overdosage, Contraindications, Other Rx Info Active Ingredients User Ratings / Reviews Side Effect Reports. Strattera News. Published Studies Curr't Clinical Trials. RECENT MAJOR CHANGES. Warnings and Precautions:. Severe Liver Injury 5.2. 08/2012. Effects on Blood Pressure and Heart Rate 5.4. 07/2012. DESCRIPTION. STRATTERA ® atomoxetine HCl is a selective norepinephrine reuptake inhibitor. Atomoxetine HCl is the R - isomer as determined by x-ray diffraction. The chemical designation is - - N -Methyl-3-phenyl-3- o ...
http://druglib.com/druginfo/strattera/description_pharmacology/
*  Angeliq (Estradiol / Drospirenone) - Description and Clinical Pharmacology
Angeliq Estradiol / Drospirenone - Description and Clinical Pharmacology. Rx drug information, pharmaceutical research, clinical trials, news, and more. Drugs By Name By Condition By Category Most Searched Ratings/Reviews Adverse Events Actives. Angeliq Estradiol / Drospirenone - Description and Clinical Pharmacology. Angeliq Rx. Summary Description and Clinical Pharmacology Indications and Dosage Warnings and Precautions Side Effects and Adverse Reactions Drug Interactions, Overdosage, Contraindications, Other Rx Info User Ratings / Reviews Side Effect Reports. Angeliq News. Published Studies Curr't Clinical Trials. Description. ANGELIQ TABLETS provide a hormone regimen consisting of film coated tablets each containing 0.5 mg of drospirenone and 1 mg of estradiol. The inactive ingredients are lactose monohydrate NF, corn starch NF, modified starch NF, povidone 25000 USP, magnesium stearate NF, hydroxylpropylmethyl cellulose USP, macrogol 6000 NF, talc USP, titanium dioxide USP, and ...
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*  People - Institute of Cellular Medicine - Newcastle University
... You are here: Newcastle University. Institute of Cellular Medicine. People. People Search. Site Map. Accessibility. Skip to Content. Newcastle University. Institute of Cellular Medicine S earch Search For:. Home. About Us. Our Research. Study With Us. Public Engagement. People. Professor Gary Ford Strategic Research Advisor Email: gary.ford@ncl.ac.uk Telephone: +44 0 1865 784957 Address: Oxford Academic Health Science Network Magdalen Centre North Oxford Science Park OX4 4GA. Profile. Research. Publications. Roles and Responsibilities. Visiting Professor of Clinical Pharmacology, Oxford University Consultant Physician, Oxford University Hospitals NHS Trust. Qualifications. BSc Hons, MBBChir, MA, FRCP, FBPharmacolS, FMedSci. Previous Positions. Jacobson Chair of Clinical Pharmacology 2007-2013 Professor of Pharmacology of Old Age, Newcastle University 2000-2007 Honorary Consultant Physician Stroke Medicine 2000-2013. Senior Lecturer/Consultant Physician in Clinical ...
http://ncl.ac.uk/icm/people/profile/gary.ford
*  Monir Ahmad (University of Ottawa, Ottawa) on ResearchGate - Expertise: Clinical Pharmacology, Patho
Monir Ahmad University of Ottawa, Ottawa on ResearchGate - Expertise: Clinical Pharmacology, Pathology, Pharmacology. For full functionality of ResearchGate it is necessary to enable JavaScript. Here are the instructions how to enable JavaScript in your web browser. Monir Ahmad. University of Ottawa, Ottawa. Clinical Pharmacology, Pathology, Pharmacology. MD, PhD. 21.98. Connect. Overview. Contributions. Info. Stats. Monir Ahmad has. 13. Publications. 112. Reads. 172. Citations. 56.32. Impact Points. View stats. Featured publications. View all. Source Available from: Frans Leenen. Article:. Enhanced expression of epithelial sodium channels causes salt-induced hypertension in mice through inhibition of the 2-isoform of Na+, K+-ATPase. Frans H. H Leenen. Xiaohong Hou. Hong‐Wei Wang. Monir Ahmad. 10. Reads. 1 Citation. Source Available from: Frans Leenen. Article:. Knockdown of mineralocorticoid or angiotensin II type 1 receptor gene expression in the paraventricular nucleus prevents ...
http://researchgate.net/profile/Monir_Ahmad
*  Frank Donath (SocraTec R&D GmbH, Oberursel) on ResearchGate - Expertise: Clinical Pharmacology, Slee
Frank Donath SocraTec R D GmbH, Oberursel on ResearchGate - Expertise: Clinical Pharmacology, Sleep Medicine, Pharmacy. For full functionality of ResearchGate it is necessary to enable JavaScript. Here are the instructions how to enable JavaScript in your web browser. Frank Donath. SocraTec R D GmbH, Oberursel. Clinical Pharmacology, Sleep Medicine, Pharmacy. 20.42. Connect. Overview. Contributions. Info. Stats. Frank Donath has. 19. Publications. 2k. Reads. 379. Citations. 32.34. Impact Points. View stats. Featured publications. View all. Article:. Relative bioavailability of a newly developed 5-mg levomethadone hydrochloride IR tablet L-Polamidon® 5 mg tablets in comparison with the 5-mg levomethadone hydrochloride oral solution L-Polamidon® solution for substitution as reference produc. Henning H Blume. Frank Donath. Katrin Roscher. Gerd Elvert. Daniel Wagner. Oliver Bley. Alexander Vuia. Marina Todorova-Sanjari. Ramon Villalobos. Barbara Schug. 18. Reads. 0 Citations. Article:. ...
http://researchgate.net/profile/Frank_Donath
*  12th International Workshop on Clinical Pharmacology of HIV Therapy, April 13-15, 2011, Miami
th international workshop on clinical pharmacology of hiv therapy april miami conference reports for natap back nbsp th international workshop on clinical pharmacology of hiv therapy april miami th international workshop on clinical pharmacology of hiv therapy report by courtney fletcher pharmd courtney v fletcher pharm d nbsp food and fat have little impact on dolutegravir a new integrase inhibitor written by mark mascolini nbsp once daily mg maraviroc explored in people taking atazanavir ritonavir written by mark mascolini nbsp lopinavir troughs lower in children on once daily dose plus efavirenz written by mark mascolini nbsp lopinavir troughs lower in children on once daily dose plus efavirenz written by mark mascolini nbsp atazanavir levels indicate need for higher dose during pregnancy written by mark mascolini nbsp four in one drug affects levels of oral contraceptives components written by mark mascolini nbsp older age may slow clearance of once daily darunavir which penetrates ...
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*  Clinical Pharmacology and Therapeutics
... redirect clinical pharmacology therapeutics
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*  European Journal of Clinical Pharmacology, Volume 0, Issue 0 - Springer
... Search Options. Advanced Search. Search Help. Search Menu. Sign up / Log in English. Deutsch. Academic edition. Corporate edition. Skip to: Main content Side column. Home. Contact Us. Browse Volumes Issues. Look Inside. Get Access. Find out how to access preview-only content. European Journal of Clinical Pharmacology All Volumes Issues Online First Articles ISSN: 0031-6970 Print 1432-1041 Online Articles not assigned to an issue 40 articles previous Page. is not a valid page number. Please enter a number between 1 and 2. of 2. Pharmacodynamics One-day front-loading with four doses of rabeprazole followed by a standard twice-daily regimen provides sufficient acid inhibition in extensive metabolizers of CYP2C19. Takuma Kagami, Mitsushige Sugimoto. Look Inside. Get Access. Clinical Trial Establishing assay sensitivity in QT studies: experience with the use of moxifloxacin in an early phase clinical pharmacology study and comparison with its effect in a thorough QT study. Rashmi R. Shah, ...
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*  Biomarkers in Clinical Pharmacology - Research and Markets
... Printer Friendly Printed from http://www.researchandmarkets.com/reports/1580985 Biomarkers in Clinical Pharmacology Description: Biomarkers are measurements that have become very powerful tools for drug development, medical practice, diagnosis and regulation throughout the healthcare sector. This Special Focus Issue of the peer-reviewed journal Biomarkers in Medicine includes 8 manuscripts highlighting the evaluation and use of biomarkers in medical practice and drug development. Ordering: Order Online - visit http://www.researchandmarkets.com/reports/1580985 Order by Fax - using the order form below Order By Post - print the order form below and send to Research and Markets, Guinness Centre, Taylors Lane, Dublin 8, Ireland. Fax order form To place a fax order simply print this form, fill in and fax the completed form to the number below. If you have any questions please email help@researchandmarkets.net Order information Please verify that the product information is correct and select the format ...
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*  Home Page ::: Current Clinical Pharmacology
... Browse Journals. Bentham Online. By Titles By Subject Browse Patent Journals Price and Ordering Information New Journals New Journals 2016 New Journals 2015 New Journals 2014. Subscription Rates Subscription Rates 2015 Subscription Rates 2014. Journals Impacting Science Free Online Samples Journal Catalogs Endorsements. Submit Manuscripts Purchase Articles Search Articles Online Feedback Social Media Bentham Insight. ISSN: 2212-3938 Online ISSN: 1574-8847 Print. Volume 10, 4 Issues, 2015. Current Clinical Pharmacology. Submit Abstracts Online. Purchase Articles. Order Reprints. Editorial Policies. Browse Contents Select Volume: Volume 10 2015 Volume 9 2014 Volume 8 2013 Volume 7 2012 Volume 6 2011 Volume 5 2010 Volume 4 2009 Volume 3 2008 Volume 2 2007 Volume 1 2006. Select Issue: Select Volume First.. Select Article: Select Issue First.. Submit Abstract via Email. Current Clinical Pharmacology, Volume 10 - Number 3. DOI: 10.2174/157488471003150820143939. Download. Reprints. Permissions. ...
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*  Annette Schroder
Publications Estrogen receptor subtypes and afferent signaling in the bladder Annette Schroder Department of Clinical Pharmacology, Lund University Hospital, 221 85 Lund, Sweden J Urol 170:1013-6. 2003 Detrusor responses to prostaglandin E2 and bladder outlet obstruction in wild-type and Ep1 receptor knockout mice Annette Schroder Department of Clinical Pharmacology, Lund University Hospital, 221 85 Lund, Sweden J Urol 172:1166-70. 2004 Protective effect of an oral endothelin converting enzyme inhibitor on rat detrusor function after outlet obstruction Annette Schroder Department of Clinical Pharmacology, Lund University Hospital, Lund, Sweden J Urol 172:1171-4. 2006 Carbon monoxide relaxes the female pig urethra as effectively as nitric oxide in the presence of YC-1 Annette Schroder Department of Clinical Pharmacology, Lund University Hospital, Lund, Sweden J Urol 167:1892-6. Detail Information Publications 6 Estrogen receptor subtypes and afferent signaling in the bladder ...
http://labome.org/expert/sweden/lund/schroder/annette-schroder-458831.html
*  I B Wilkinson
2013 Inhibition of basal nitric oxide synthesis increases aortic augmentation index and pulse wave velocity in vivo Ian B Wilkinson Clinical Pharmacology Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, UK Br J Clin Pharmacol 53:189-92. 2002 Heart rate dependency of pulse pressure amplification and arterial stiffness Ian B Wilkinson Clinical Pharmacology Unit, University of Edinburgh, Western General Hospital, United Kingdom Am J Hypertens 15:24-30. Inhibition of basal nitric oxide synthesis increases aortic augmentation index and pulse wave velocity in vivo Ian B Wilkinson Clinical Pharmacology Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, UK Br J Clin Pharmacol 53:189-92. Heart rate dependency of pulse pressure amplification and arterial stiffness Ian B Wilkinson Clinical Pharmacology Unit, University of Edinburgh, Western General Hospital, United Kingdom Am J Hypertens 15:24-30. 2006 Aortic ...
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*  Somavert (Pegvisomant) Drug Information: Clinical Pharmacology - Prescribing Information at RxList
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*  Omidria (Phenylephrine and Ketorolac Injection) Drug Information: Clinical Pharmacology - Prescribin
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*  DiaBeta (Glyburide Tablets) Drug Information: Clinical Pharmacology - Prescribing Information at RxL
DiaBeta Glyburide Tablets Drug Information: Clinical Pharmacology - Prescribing Information at RxList. Pill Identifier Search. Drugs A-Z. Pill Identifier. diabeta glyburide tablets side effects drug center. diabeta glyburide tablets drug - clinical pharmacology. FDA Approves Jardiance to Treat Type 2 Diabetes "The U.S. Type 2 diabetes affects approximately 26 million people a"... Read the FDA Approves Jardiance to Treat Type 2 Diabetes article. Type 2 Diabetes Slideshow Pictures. Type 2 Diabetes Quiz. Pharmacokinetics Single-dose studies with Dia eta in normal subjects demonstrate significant absorption within one hour, peak drug levels at about four hours, and low but detectable levels at twenty-four hours. Multiple-dose studies with Dia eta in diabetic patients demonstrate drug level concentration-time curves similar to single-dose studies, indicating no build-up of drug in tissue depots. The blood glucose lowering effect persists for 24 hours following single morning doses in non-fasting ...
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*  Minipress (Prazosin HCl) Drug Information: Clinical Pharmacology - Prescribing Information at RxList
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*  Uceris (Budesonide Extended-Release Tablets) Drug Information: Clinical Pharmacology - Prescribing I
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*  Rhophylac (Immune Globulin Intravenous (Human) solution) Drug Information: Clinical Pharmacology - P
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*  Extavia (Interferon Beta-1b Kit) Drug Information: Clinical Pharmacology - Prescribing Information a
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*  Tasigna Capsules (Nilotinib Capsules) Drug Information: Clinical Pharmacology - Prescribing Informat
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*  Zegerid (Omeprazole, Sodium Bicarbonate) Drug Information: Clinical Pharmacology - Prescribing Infor
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*  Proleukin (Aldesleukin for Injection) Drug Information: Clinical Pharmacology - Prescribing Informat
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*  Prinivil (Lisinopril) Drug Information: Clinical Pharmacology - Prescribing Information at RxList
Prinivil Lisinopril Drug Information: Clinical Pharmacology - Prescribing Information at RxList. Like Us. Follow Us. About Us. Pill Identifier Search. October 7, 2015. Home. Drugs A-Z. Pill Identifier. Supplements. Slideshows. Images. Symptom Checker. Diseases. Dictionary. Quizzes. home. drugs a-z list. prinivil lisinopril side effects drug center. prinivil lisinopril drug - clinical pharmacology. Recommended Topic Related To: Prinivil. Elevated BP May Prematurely Age the Brain "Nov. 1, 2012 -- Having even mildly elevated blood pressure at midlife prematurely ages the brain, a new study shows. Researchers say the early changes seen with higher blood pressure may set the stage for problems with thinking, memor"... Read the Elevated BP May Prematurely Age the Brain article. Previous. 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. Next. Prinivil User Reviews >> Prinivil. High Blood Pressure Hypertension Slideshow. Take the Salt Quiz. Lowering Blood Pressure Exercise Tips Pictures. Drug Description ...
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*  Adalat CC (Nifedipine) Drug Information: Clinical Pharmacology - Prescribing Information at RxList
Adalat CC Nifedipine Drug Information: Clinical Pharmacology - Prescribing Information at RxList. Drugs A-Z. Pill Identifier. adalat cc nifedipine side effects drug center. adalat cc nifedipine drug - clinical pharmacology. Adalat CC User Reviews >> Adalat CC. High Blood Pressure Hypertension Slideshow. Drug Description Patient Information. CLINICAL PHARMACOLOGY Nifedipine is a calcium ion influx inhibitor slow-channel blocker or calcium ion antagonist which inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. The increased peripheral vascular resistance, an underlying cause of hypertension, results from an increase in active tension in the vascular smooth muscle. Nifedipine is a peripheral arterial vasodilator which acts directly on vascular smooth muscle. The reduction in calcium influx by nifedipine causes arterial vasodilation and decreased peripheral vascular resistance which results in reduced arterial blood pressure. When Adalat CC ...
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*  Requip (Ropinirole Hcl) Drug Information: Clinical Pharmacology - Prescribing Information at RxList
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*  Drug Information for Albuterol Sulfate (Mylan Pharmaceuticals Inc.): CLINICAL PHARMACOLOGY
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*  The Infoplease Crossword Puzzle: Transportation
... infoplease Atlas. Encyclopedia. Dictionary. Thesaurus. Day in History. Atlas. History. Fifty States. Atlas. History. Military. People People. People Home. Business. Government. Science. History Gov't History Gov't. History Gov't Home. World History. History. Government. Science Health Science Health. Science Health Home. Health. Life Science. Physical Science. Calendar Holidays Calendar Holidays. Calendar Holidays Home. Calendars. Holidays. Business Business. Business Home. Business. Click "Reveal" for the answer to an individual clue Click "Check" to see if you've made any mistakes Click "Solution" to reveal all the answers Get help in the Crossword Puzzle Guide Find more crosswords in the Crossword Archive Learn the history of the crossword puzzle Find a word using our Crossword Search. * Treat your Tired Tootsies with These after They have Transported you around Town: Sort of Soothing Salts bkwds. 6 * Voyage Something for which various modes of transport would be used in order to get to the far off ...
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*  Guardian Prize crossword
... Cancel Report This Post Please fill out the form below with your name, e-mail address and the reason s you wish to report this post. Crossword Clue Solver - The Crossword Solver. Quick Solve. Solution Wizard. Dictionary. Online Shop. Crossword Help Forum. Contact. Home Quick Solve Solution Wizard Dictionary Online Shop Crossword Help Forum Contact. Crossword Help Forum Forum Rules. Forum. Guardian Prize crossword Log In. Register. fred 12th July 2009, 12:31. Can anyone help with the following. Disease encompassing land returned by poet former name 7 I have ??R?E?T Lento,foster-father of Greek vase 4,4 ?L?W ?I?E slow time. 1 of 10 - Report This Post. celadon 12th July 2009, 13:41. Last one maybe:- Beaulieu 2 of 10 - Report This Post. sumi 12th July 2009, 14:34. Disease encompassing land returned by poet former name : Barrett Maiden name of Elisabeth Barrett Browning, the disease is TB and the land is terra, both backwards 3 of 10 - Report This Post. dt 12th July 2009, 16:29. "Thou foster-child of silence ...
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*  Bay Area Crossword Puzzle Tournament September 13, 2014
... Seventh Annual Bay Area Crossword Puzzle Tournament Saturday, September 13, 2014 in Oakland, California 2014 Tournament Results 2013 Tournament Results 2012 Tournament Results 2011 Tournament Results. to benefit Families of SMA, which is dedicated to finding a treatment and cure for Spinal Muscular Atrophy, a devastating disease which is the number one genetic killer of children under age two. Saturday, September 13, 2014, 11:30am to 4:00pm at CSU East Bay, 1000 Broadway, Suite 109 map, Oakland, California 94607 Couldn't make it to the American Crossword Puzzle Tournament in Brooklyn this year. Can't get enough crossword competition. Then come join other Bay Area crossword puzzle aficionados and enjoy a day of friendly competition to benefit a very worthy cause, Families of SMA. The Puzzles The legendary Will Shortz, crossword puzzle editor of the New York Times, has graciously agreed to donate unpublished puzzles from future editions of the Times. Rankings will be based on the total score ACPT rules on ...
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*  Non-invasive combined surrogates of remifentanil blood concentrations with relevance to analgesia -
... Springer. Affiliated with Institute of Clinical Pharmacology, Pharmazentrum Frankfurt/ZAFES, Goethe-University Fraunhofer Project Group Translational Medicine and Pharmacology IME-TMP. Affiliated with Institute of Clinical Pharmacology, Pharmazentrum Frankfurt/ZAFES, Goethe-University Institute for Translational Medicine and Therapeutics, Department of Pharmacology, University of Pennsylvania Perelman School of Medicine. Affiliated with Institute of Clinical Pharmacology, Pharmazentrum Frankfurt/ZAFES, Goethe-University Department of Nephrology and Rheumatology, Krankenhaus der Barmherzigen Brüder, Teaching Hospital of the University of Mainz. Affiliated with Department of Anesthesia, Intensive Care and Pain Therapy, Goethe-University. Affiliated with Institute of Clinical Pharmacology, Pharmazentrum Frankfurt/ZAFES, Goethe-University. Affiliated with Institute of Clinical Pharmacology, Pharmazentrum Frankfurt/ZAFES, Goethe-University Fraunhofer Project ...
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*  NIH Clinical Center
... Back to: Clinical Center Home Page. About the Clinical Center. Back to Top CC pharmacology course expands to China There is a growing interest in clinical pharmacology worldwide, given that it provides the scientific basis for drug development and drug utilization in therapeutics. China, like other emerging medical communities, is interested in establishing a viable pharmaceutical industry base and in training professionals in the principles of clinical pharmacology and drug development sciences. In November, the Clinical Center Office of Clinical Research Training and Medical Education was invited by a nonprofit organization, GlobalMD, to present its Principles of Clinical Pharmacology course in Beijing. Arthur Atkinson, adjunct professor at Northwestern University Feinberg School of Medicine Department of Molecular Pharmacology and former Principles of Clinical Pharmacology course director and textbook editor; and Dr. David Flockhart, a Principles of Clinical ...
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*  Jatinder K Lamba
Publications Genetic factors influencing cytarabine therapy Jatinder K Lamba Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA Pharmacogenomics 10:1657-74. 2009 Identification of predictive markers of cytarabine response in AML by integrative analysis of gene-expression profiles with multiple phenotypes Jatinder K Lamba Department of Experimental and Clinical Pharmacology, University of Minnesota, MN, USA Pharmacogenomics 12:327-39. 2011 Pathway-based pharmacogenomics of gemcitabine pharmacokinetics in patients with solid tumors Amit K Mitra Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA Pharmacogenomics 13:1009-21. 2012 Genetic variants in cytosolic 5'-nucleotidase II are associated with its expression and cytarabine sensitivity in HapMap cell lines and in patients with acute myeloid leukemia Amit K Mitra Department of Experimental and Clinical ...
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*  Peter Sever
Observations from the Anglo-Scandinavian Cardiac Outcomes Trial ASCOT Peter S Sever Clinical Pharmacology and Therapeutics, Imperial College London, International Centre for Circulatory Health, 59 North Wharf Road, London W2 1LA, UK Eur Heart J 33:2970-9. 2012 Coronary heart disease benefits from blood pressure and lipid-lowering Peter S Sever Clinical Pharmacology and Therapeutics, Imperial College London, International Centre for Circulatory Health, London, UK Int J Cardiol 135:218-22. 2006 Potential synergy between lipid-lowering and blood-pressure-lowering in the Anglo-Scandinavian Cardiac Outcomes Trial Peter Sever Clinical Pharmacology and Therapeutics, Imperial College London, International Centre for Circulatory Health, 59 North Wharf Road, London W2 1PG, UK Eur Heart J 27:2982-8. Observations from the Anglo-Scandinavian Cardiac Outcomes Trial ASCOT Peter S Sever Clinical Pharmacology and Therapeutics, Imperial College London, International Centre for Circulatory Health, ...
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*  Arthur Atkinson | National Institutes of Health | ZoomInfo.com
Arthur Atkinson. National Institutes of Health. ZoomInfo.com. Zoom Information Find Contacts. Careers. FAQ. Sign Up for Free. Login Customers. Our Customers. Marketing. Sales. Recruiting. Enterprise. Partners. Case Studies. Products. ZoomInfo Data Services. ZoomInfo Pro. ZoomInfo List Builder. ZoomInfo Community Edition. ZoomInfo Connect. ZoomInfo API. ZoomInfo for Salesforce. Pricing. Pricing. About. Our Company. Data Sources. Leadership. News and Press. Awards. Partners. Careers. Customer Support. Contact Us. Free Trial. People. Companies. Need more. Try our Advanced Search 20+ criteria ». Share This Profile. Share this profile on Facebook. Link to this profile on LinkedIn. Tweet this profile on Twitter. Email a link to this profile. See other services through which you can share this profile. This profile was last updated on 1/25/13 and contains information from public web pages and contributions from the ZoomInfo community. Is this you. Claim your profile. Dr. Arthur J. Atkinson Jr. Wrong Dr. Arthur J. ...
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*  Guide to Pharmacology
The Guide to PHARMACOLOGY is developed as a joint venture between the International Union of Basic and Clinical Pharmacology IUPHAR and the British Pharmacological Society BPS, and replaces and expands upon the IUPHAR Database. The information featured on the Guide to PHARMACOLOGY includes pharmacological data, target and gene nomenclature, and curated chemical information for ligands. Background and development Content and features The Concise Guide to PHARMACOLOGY Database links Future directions See also References External links. As with the original IUPHAR Database site, NC-IUPHAR, the International Union of Basic and Clinical Pharmacology IUPHAR Committee on Receptor Nomenclature and Drug Classification, acts as the scientific advisory and editorial board for the database. Within each page, targets are arranged into lists of tables, with each table including the protein and gene nomenclature for the target with links to gene nomenclature databases, and listing ...
https://en.wikipedia.org/wiki/Guide_to_Pharmacology
*  Crossword puzzles - UK Mercury No.34 printable crossword puzzle
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*  Crossword puzzles - US Prefect No.63 printable crossword puzzle
... Your browser does not support inline frames or is currently configured not to display inline frames. Your browser does not support inline frames or is currently configured not to display inline frames. Your browser does not support inline frames or is currently configured not to display inline frames. US Prefect No.63. Cash prize - email a friend about this site. Crosswords on your website. Crosswords in your publications Free screensavers Free word fun game. Crosswords for schools. Baffled. Home Solution. Your browser does not support inline frames or is currently configured not to display inline frames. Your browser does not support inline frames or is currently configured not to display inline frames. Crossword puzzle by www.crosswordsite.com. Across 1. Person without close friends 4,4 7. East Indian tree yielding a yellow dye 11. Unit of capacitance 12. Tuberous herbaceous perennials 14. Inhabitant of Oman 15. Come on 16. Chafe 17. Separate 18. Fastener for a door 19. Rubbish Brit 20. Get lost. 22. ...
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*  Can crossword puzzles help prevent dementia? - Health & Wellbeing
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http://abc.net.au/health/talkinghealth/factbuster/stories/2008/03/05/1965056.htm
*  9780838505656 | Basic & Clinical Pharmacology (7th) | Katzung, Bertram G., Md., Ph.D.; Katzung, Bert
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*  Clinical pharmacology of paclitaxel in relation of patient age: CALGB 9762 | Oncolink - Cancer Resou
Clinical pharmacology of paclitaxel in relation of patient age: CALGB 9762. Oncolink - Cancer Resources. Tipos de Cancer. Tipos de Cancer. Metastatic Cancer. C nceres de la Piel. C nceres de la V a Urinaria. C nceres del Hueso. C nceres del Pulm n. Tumores del Cerebro. Tratamiento del Cancer. Medicamentos, Salud Historia y el riesgo de cancer. Clinical pharmacology of paclitaxel in relation of patient age: CALGB 9762 Li Liu, MD University of Pennsylvania Cancer Ultima Vez Modificado: 13 e mayo el 2001. A total of 148 patients, age 55 years or older, with various non hematologic malignancies were included in this prospective study Total body Clearance TBC and toxicity of paclitaxel were evaluated None of the patients received paclitaxel previously There were 3 patient cohorts: 55 64 years, 65 74 years, and 75 years and older. There is significant interpatient variability in paclitaxel clearance and age related changes account for only of modest proportion Clinical trials evaluating the effects ...
http://es.oncolink.org/conferences/article1.cfm?id=307
*  Raymond D Pratt
2003 Concurrent administration of donepezil HCl and risperidone in patients with schizophrenia: assessment of pharmacokinetic changes and safety following multiple oral doses Josephine F Reyes Clinical Pharmacology, Eisai Medical Research Inc, Ridgefield Park, NJ 07660, USA Br J Clin Pharmacol 58:50-7. 2004 Concurrent administration of donepezil HCl and levodopa/carbidopa in patients with Parkinson's disease: assessment of pharmacokinetic changes and safety following multiple oral doses Chukwuemeka S Okereke Clinical Pharmacology, Eisai Medical Research Inc, Ridgefield Park, NJ 07660, USA Br J Clin Pharmacol 58:41-9. 2004 Concurrent administration of donepezil HCl and sertraline HCl in healthy volunteers: assessment of pharmacokinetic changes and safety following single and multiple oral doses Christa F Nagy Clinical Pharmacology, Eisai Medical Research Inc, Ridgfield Park, NJ 07660, USA Br J Clin Pharmacol 58:25-33. Concurrent administration of donepezil HCl and risperidone in patients ...
http://labome.org/expert/usa/eisai/pratt/raymond-d-pratt-527420.html
*  Clinical Pharmacology of Gastrointestinal and Liver Disease An Issue of Gastroenterology Clinics | 9
Clinical Pharmacology of Gastrointestinal and Liver Disease An Issue of Gastroenterology Clinics. Elsevier. Skip to content Feedback Menu. REST MAGIC. Products - Book. Info/Buy. Clinical Pharmacology of Gastrointestinal and Liver Disease An Issue of Gastroenterology Clinics By Richard Hunt, MB, FRCP, FRCPEd, FRCPC, FACG, AGAF, Professor of Medicine, Division of Gastroenterology, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada Dr. Hunt has assembled a group of top experts to discuss the newest and most successful medical therapies to treat gastrointestinal diseases. The issue is divided into sections devoted to each of these diseases states or disorders: acid-related disorders, functional gastrointestinal disorders, inflammatory bowel disease, gastrointestinal oncology, and hepatitis; the last 2 articles address the future directions in gastrointestinal pharmacotherapy. Articles of special interest include those on Anti-TNFα Drugs and New Biological Drugs for IBD, ...
http://elsevier.com/books/clinical-pharmacology-of-gastrointestinal-and-liver-disease-an-issue-of-gastroenterology-clinics/hunt/978-1-4377-2524-7
*  online | Resistant Hypertension Course
Resistant Hypertension Course. Jean Marco invites you to share your comments on the result of the Reduction of Atherothrombosis for Continued Health REACH registry recently published « Resistant hypertension: a frequent and ominous finding among hypertensive patients with atherothrombosis » Eur Heart J 2013 34 16 : 1204-1214. I would like to share with you this recently published study « Hypertensive target organ damage and the risk for vascular events and all-cause mortality in patients with vascular disease » and to ask you to give your point of view on it. By Atul Pathak, Professor of Cardiology and Clinical Pharmacology and RHC 2013 Faculty member Medical education and behaviour: it's time to change. By Atul Pathak, Professor of Cardiology and Clinical Pharmacology and RHC 2013 Faculty member About the RHC Course and beyond By Jean Marco, Honorary Chairman of PCR. Targets of the pharmacological approach of hypertension By Atul Pathak, Professor of Cardiology and Clinical Pharmacology ...
http://resistanthypertensioncourse.com/rhc-group/online?page=5
*  Behrouz Kassai
... EA 643 Clinical Pharmacology Unit, Claude Bernard University, Facultá RTH Laennec, Rue Guillaume Paradin BP 8071 69376, Lyon 08, France J Clin Epidemiol 56:977-82. 2003 Reappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials Rémy Boussageon Department of General Medicine, Universite Claude Bernard Lyon 1, Lyon, France PLoS Med 9:e1001204. 2009 The true treatment benefit is unpredictable in clinical trials using surrogate outcome measured with diagnostic tests Behrouz Kassai Department of Clinical Pharmacology EA 3736, University Hospital of Lyon, Rue Guillaume Paradin, BP 8071, Lyon cedex 08 69376, France J Clin Epidemiol 58:1042-51. 2005 A systematic review of the accuracy of ultrasound in the diagnosis of deep venous thrombosis in asymptomatic patients Behrouz Kassai Clinical Pharmacology Unit, Rue Guillaume Paradin BP8071 69376, Lyon Cedex 08, France Thromb Haemost 91:655-66. Behrouz Kassai EA 643 Clinical ...
http://labome.org/expert/france/kassai/behrouz-kassai-1034981.html
*  .. 16th International Workshop on Clinical Pharmacology of HIV & Hepatitis Therapy
th international workshop on clinical pharmacology of hiv hepatitis therapy dear colleague the th edition of the international workshop on clinical pharmacology of hiv hepatitis therapy â organized may in washington dc usa has been an enormous success â the organizing committee and the organizing committee would like to thank all invited speakers and participants for their contribution to this workshop in particularâ we would like to thank our sponsors abbvie â viiv healthcare bms gilead and janssenâ for making this workshop possible the abstract book as well as the slides of the presentations given during the meeting providing the speaker s consent was received will be published online at www infectiousdiseasesonline com soon the th edition of the workshop will be tentatively held on â may in washington dc usa please feel free to subscribe to our newsletter to stay informed on the latest developments we look forward to welcoming you to the workshop in the organizing committe
http://virology-education.com/event/upcoming/16th-international-workshop-clinical-pharmacology-hiv-hepatitis-therapy/
*  Onfi (Clobazam Tablets and Oral Suspension) Drug Information: Clinical Pharmacology - Prescribing In
Onfi Clobazam Tablets and Oral Suspension Drug Information: Clinical Pharmacology - Prescribing Information at RxList. onfi clobazam tablets and oral suspension side effects drug center. onfi clobazam tablets and oral suspension drug - clinical pharmacology. In a small study, the pharmacokinetics of a 20 mg single oral dose of ONFI in 9 patients with liver impairment were compared to healthy controls N=6. Drug Interaction Studies In vitro studies Clobazam did not inhibit CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP3A4, UGT1A1, UGT1A4, UGT1A6, or UGT2B4 in vitro. In vivo studies Potential for ONFI to Affect Other Drugs The effect of repeated 40 mg once-daily doses of ONFI on the pharmacokinetic profiles of single-dose dextromethorphan CYP2D6 substrate, midazolam CYP3A4 substrate, caffeine CYP1A2 substrate, and tolbutamide CYP2C9 substrate, was studied when these probe substrates were given as a drug cocktail N=18. Study 1 Study 1 N=238 was a randomized, double-blind, placebo-controlled study ...
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*  Limbrel (Flavocoxid) Drug Information: Clinical Pharmacology - Prescribing Information at RxList
Limbrel Flavocoxid Drug Information: Clinical Pharmacology - Prescribing Information at RxList. Drugs A-Z. limbrel flavocoxid side effects drug center. limbrel flavocoxid drug - clinical pharmacology. Limbrel User Reviews >> Limbrel. Drug Description Patient Information. Food Effects LIMBREL flavocoxid is safe taken with or without other foods. Food does not affect the metabolism of LIMBREL flavocoxid and may buffer effects of slight indigestion. The data for CYP inhibition is shown below: Table 1. Clinical Experience LIMBREL flavocoxid has demonstrated significant functional improvements when used for the clinical dietary management of the metabolic processes of OA. Primary endpoints were the short WOMAC composite index Western Ontario and McMaster Universities Osteoarthritis Index, investigator VAS for global response, subject VAS scales for global response and discomfort. There were no differences in demographic characteristics or in baseline WOMAC or VAS scores between the two arms. In ...
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*  Testim (Testosterone Gel) Drug Information: Clinical Pharmacology - Prescribing Information at RxLis
Testim Testosterone Gel Drug Information: Clinical Pharmacology - Prescribing Information at RxList. Drugs A-Z. testim testosterone gel side effects drug center. testim testosterone gel drug - clinical pharmacology. Drug Description Patient Information. Multiple Dose With single daily applications of Testim 50 mg and 100 mg, follow-up measurements at 30 and 90 days after starting treatment have confirmed that serum testosterone and DHT concentrations are generally maintained within the normal range. Potential for Testosterone Transfer from Male Patients to Female Partners The potential for dermal testosterone transfer following Testim use was evaluated in two clinical trials with males dosed with Testim and their untreated female partners. In the first four groups, 100 mg of Testim was applied to the male abdomen and the couples were then asked to rub abdomen-to-abdomen for 15 minutes at 1 hour, 4 hours, 8 hours or 12 hours after dose application, respectively. In these couples, serum ...
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*  Tikosyn (Dofetilide) Drug Information: Clinical Pharmacology - Prescribing Information at RxList
Tikosyn Dofetilide Drug Information: Clinical Pharmacology - Prescribing Information at RxList. tikosyn dofetilide side effects drug center. tikosyn dofetilide drug - clinical pharmacology. Drug-Drug Interactions see PRECAUTIONS Dose-Response and Concentration Response for Increase in QT Interval Increase in QT interval is directly related to dofetilide dose and plasma concentration. A linear relationship between mean QTc increase and dofetilide dose was also seen in patients with renal impairment, in patients with ischemic heart disease, and in patients with supraventricular and ventricular arrhythmias. Note: The range of dofetilide plasma concentrations achieved with the 500 mcg BID dose adjusted for creatinine clearance is 1 3.5 ng/mL. Clinical Studies Chronic Atrial Fibrillation And/Or Atrial Flutter Two randomized, parallel, double-blind, placebo-controlled, dose-response trials evaluated the ability of TIKOSYN 1 to convert patients with atrial fibrillation or atrial flutter AF/AFl of more ...
http://rxlist.com/tikosyn-drug/clinical-pharmacology.htm
*  Comtan (Entacapone) Drug Information: Clinical Pharmacology - Prescribing Information at RxList
Comtan Entacapone Drug Information: Clinical Pharmacology - Prescribing Information at RxList. comtan entacapone side effects drug center. comtan entacapone drug - clinical pharmacology. Comtan User Reviews >> Comtan. Clinical Studies The effectiveness of Comtan entacapone as an adjunct to levodopa in the treatment of Parkinson's disease was established in three 24-week multicenter, randomized, double-blind, placebo-controlled studies in patients with Parkinson's disease. In the first two studies to be described, patients were randomized to receive placebo or entacapone 200 mg administered concomitantly with each dose of levodopa and carbidopa up to 10 times daily, but averaging 4 doses to 6 doses per day. In one study, conducted in the Nordic countries, the primary outcome measure was the total mean time spent in the On state during an 18-hour diary recorded day 6 AM to midnight. In the other study, the primary outcome measure was the proportion of awake time spent over 24 hours in the On ...
http://rxlist.com/comtan-drug/clinical-pharmacology.htm
*  Neulasta (Pegfilgrastim) Drug Information: Clinical Pharmacology - Prescribing Information at RxList
Neulasta Pegfilgrastim Drug Information: Clinical Pharmacology - Prescribing Information at RxList. neulasta pegfilgrastim side effects drug center. neulasta pegfilgrastim drug - clinical pharmacology. Based on the correlation between the duration of severe neutropenia and the incidence of febrile neutropenia found in studies with filgrastim, duration of severe neutropenia was chosen as the primary endpoint in both studies, and the efficacy of Neulasta was demonstrated by establishing comparability to filgrastim-treated patients in the mean days of severe neutropenia. In Study 1, 157 patients were randomized to receive a single subcutaneous injection of Neulasta 6 mg on day 2 of each chemotherapy cycle or daily subcutaneous filgrastim 5 mcg/kg/day beginning on day 2 of each chemotherapy cycle. Both studies met the major efficacy outcome measure of demonstrating that the mean days of severe neutropenia of Neulasta-treated patients did not exceed that of filgrastim-treated patients by more than 1 ...
http://rxlist.com/neulasta-drug/clinical-pharmacology.htm
*  Zelnorm (Tegaserod Maleate) Drug Information: Clinical Pharmacology - Prescribing Information at RxL
Zelnorm Tegaserod Maleate Drug Information: Clinical Pharmacology - Prescribing Information at RxList. zelnorm tegaserod maleate side effects drug center. zelnorm tegaserod maleate drug - clinical pharmacology. Zelnorm User Reviews >> Zelnorm. The study design consisted of a 4-week placebo-free baseline period followed by a 12-week double-blind treatment period. Each week of the 4-week placebo-free baseline period and the 12-week double-blind treatment period, patients were asked the question, "Please consider how you felt this past week in regard to your IBS, in particular your overall well-being, and symptoms of abdominal discomfort, pain and altered bowel habit. Patients were classified as responders within a month if they were considerably or completely relieved for at least two of the four weeks, or if they were at least somewhat relieved for each of the four weeks. Study Zelnorm tegaserod maleate. Response: > 2 of 4 weeks complete or considerable relief or 4 of 4 weeks with at least ...
http://rxlist.com/zelnorm-drug/clinical-pharmacology.htm
*  Vantas (Histrelin Acetate) Drug Information: Clinical Pharmacology - Prescribing Information at RxLi
Vantas Histrelin Acetate Drug Information: Clinical Pharmacology - Prescribing Information at RxList. Drugs A-Z. vantas histrelin acetate side effects drug center. vantas histrelin acetate drug - clinical pharmacology. Vantas User Reviews >> Vantas Drug Description Patient Information. When histrelin serum concentrations were measured following a second implant inserted after 52 weeks, the observed serum concentrations over 8 weeks following the second implant were comparable to the same period following the first implant. Serum histrelin concentrations were proportional to dose after one, two or four 50 mg VANTAS implants 50, 100 or 200 mg as histrelin acetate in 42 prostate cancer patients. Figure 1: Mean Serum Histrelin Concentration versus Time Profile for 17 Patients Following Insertion of First and Second VANTAS Implants. The apparent clearance following a 50 mg as histrelin acetate VANTAS implant in 17 prostate cancer patients was 174 56.5 mL/min mean SD. In these 17 patients, mean serum ...
http://rxlist.com/vantas-drug/clinical-pharmacology.htm
*  OptiMARK (Gadoversetamide Injection) Drug Information: Clinical Pharmacology - Prescribing Informati
OptiMARK Gadoversetamide Injection Drug Information: Clinical Pharmacology - Prescribing Information at RxList. Drugs A-Z. optimark gadoversetamide injection side effects drug center. optimark gadoversetamide injection drug - clinical pharmacology. As shown in Table 5, the first row of each endpoint group represents the difference in the mean score of the combined pre-and post-contrast MRI from the mean score of the pre-contrast MRI alone. Also, the table shows the number of patients whose paired MRI images were better, worse or the same as the pre-contrast MRI. Table 5 :Results of MRI Central Nervous System Studies with 0.1 mmol/kg OptiMARK Endpoints Study A Study B. Number of Lesions: Difference of Means. Confidence in Number of Lesions: Difference of Means 0.11* 0.56*. a Difference of means = Side-by-side pre-and post-OptiMARK mean - pre-mean b Pair = Side-by-side pre-and post-OptiMARK * Statistically significant for both the median Wilcoxon test and mean paired t test Statistically ...
http://rxlist.com/optimark-drug/clinical-pharmacology.htm
*  Valentin Rose (pharmacologist)
valentin rose pharmacologist valentin rose pharmacologist valentin rose the younger october august was a german pharmacologist from berlin margraviate of brandenburg son of valentin rose the elder beginning in he spent four years as a pharmacy apprentice in frankfurt am main afterwards returning to berlin where he worked as an assistant at his late father s pharmacy in berlin he attended lectures given by johann gottlieb gleditsch and martin klaproth at the collegium medico chirurgicum in he became provisor of his father s pharmacy of which he gained ownership of in at ndb adb deutsche biographie he is credited with the discoveries of sodium bicarbonate and inulin from elecampane root he also developed a method for the detection of arsenic to be used in criminal investigations with adolf ferdinand gehlen he was an editor of the berlinisches jahrbuch für die pharmacie und für die damit verhundenen wissenschaften berlinisches jahrbuch für die pharmacie edited successively by v rose a f gehlen j w doebereiner c ...
https://en.wikipedia.org/wiki/Valentin_Rose_(pharmacologist)
*  Engineering & Science Crossword Puzzle - October 4, 2009 - RF Cafe
Engineering Science Crossword Puzzle - October 4, 2009 - RF Cafe. Custom Search. More than 12,000 searchable pages indexed. Your RF Cafe Progenitor Webmaster Kirt Blattenberger ... single-handedly redefining what an engineering website should be. •−• ••−• −•−• •− ••−• • RF Cafe Morse Code Hear It. About RF Cafe. October 4, 2009 Engineering Science Crossword Puzzle. Note: A standard for crossword puzzles is when all words in a clue are capitalized, the solution is the abbreviation or acronym for that clue; e.g., Alternating Current = AC. 2009 Engineering Science Crossword Puzzles 2015. Reproduction of this puzzle without the express permission of RF Cafe is prohibited. Asynchronous Communication Interface Adapter abbr. Stock symbol for National Semiconductor 14. BlackBerry or Jordana for example abbr., pl. Spurious RF products created by metal joints abbr. Unit of apparent power abbr. Chemical symbol for chlorine 21. Greek letter 22. Type of digital filter abbr. Voltage-current phase mnemonic 32. Type of ...
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*  Engineering & Science Crossword Puzzle - November 14, 2010 - RF Cafe
Engineering Science Crossword Puzzle - November 14, 2010 - RF Cafe. More than 12,000 searchable pages indexed. Your RF Cafe Progenitor Webmaster Kirt Blattenberger ... •−• ••−• −•−• •− ••−• • RF Cafe Morse Code Hear It. About RF Cafe. Engineering Science Crossword Puzzle November 14, 2010. Note: A standard for crossword puzzles is when all words in a clue are capitalized, the solution is the abbreviation or acronym for that clue; e.g., Alternating Current = AC. 2010 Engineering Science Crossword Puzzles 2015. - Dec 19, Dec 12, Dec 5 - Nov 28, Nov 21, Nov 14, Nov 7 - Oct 31, Oct 24, Oct 17, Oct 10, Oct 3 - Sep 26, Sep 12, Sep 5 - Aug 29, Aug 22 - Jul 25, Jul 18, Jul 11, Jul 4 - Jun 27, Jun 20, Jun 13, Jun 6 - May 30, May 23, May 16, May 9, May 2 - Apr 25, Apr 18, Apr 11, Apr 4 - Mar 28, Mar 21, Mar 14, Mar 7 - Feb 28, Feb 21, Feb 14, Feb 7 - Jan 31, Jan 24, Jan 17, Jan 10, Jan 3 Reproduction of this puzzle without the express permission of RF Cafe is prohibited. Chemical symbol for ytterbium 13. RF passive ...
http://rfcafe.com/miscellany/crosswords/2010/crossword-11-14-2010.htm

European Association for Clinical Pharmacology and TherapeuticsFragment-based lead discovery: Fragment-based lead discovery (FBLD) also known as fragment-based drug discovery (FBDD) is a method used for finding lead compounds as part of the drug discovery process. It is based on identifying small chemical fragments, which may bind only weakly to the biological target, and then growing them or combining them to produce a lead with a higher affinity.Timeline of the nuclear program of Iran: This is the timeline of the nuclear program of Iran.Drug action: The action of drugs on the human body is called pharmacodynamics, and what the body does with the drug is called pharmacokinetics. The drugs that enter the human tend to stimulate certain receptors, ion channels, act on enzymes or transporter proteins.List of pharmaceutical compound number prefixes: This list of pharmaceutical compound number prefixes details a pharmaceutical drug labeling standard. Pharmaceutical companies produce a large number of compounds, which cannot all be given names.Concentration effect: In the study of inhaled anesthetics, the concentration effect is the increase in the rate that the Fa(alveolar concentration)/Fi(inspired concentration) ratio rises as the alveolar concentration of that gas is increased. In simple terms, the higher the concentration of gas administered, the faster the alveolar concentration of that gas approaches the inspired concentration.Proton-sensing G protein-coupled receptorsInternational Committee on Aeronautical Fatigue and Structural IntegrityLigand (biochemistry): In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose. In protein-ligand binding, the ligand is usually a signal-triggering molecule binding to a site on a target protein.International Society for Traumatic Stress Studies: International Society for Traumatic Stress Studies (ISTSS) was established on March 2, 1985 in Washington, D.C.John Killaly: John Killaly (1776–1832) was the most significant Irish canal engineer working originally for the Grand Canal company and later, as an engineer, under the Directors-General of Inland Navigation.List of podcasting companies: This is a list of notable podcast production and distribution companies. This includes both audio and video podcasts.The Flash ChroniclesInternational Psychopharmacology Algorithm Project: The International Psychopharmacology Algorithm Project (IPAP) is a non-profit corporation whose purpose is to "enable, enhance, and propagate" use of algorithms for the treatment of some Axis I psychiatric disorders.Idiosyncratic drug reactionPharmacogenetics: Pharmacogenetics is the study of inherited genetic differences in drug metabolic pathways which can affect individual responses to drugs, both in terms of therapeutic effect as well as adverse effects. The term pharmacogenetics is often used interchangeably with the term pharmacogenomics which also investigates the role of acquired and inherited genetic differences in relation to drug response and drug behavior through a systematic examination of genes, gene products, and inter- and intra-individual variation in gene expression and function.Loftus, North YorkshireGABAA-rho receptor: The GABAA-rho receptor (previously known as the GABAC receptor) is a subclass of GABAA receptors composed entirely of rho (ρ) subunits. GABAA receptors including those of the ρ-subclass are ligand-gated ion channels responsible for mediating the effects of gamma-amino butyric acid (GABA), the major inhibitory neurotransmitter in the brain.Neuropharmacology: Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular.Org 20599WIN 56,098: WIN 56,098 is a chemical that is considered to be an aminoalkylindole derivative. It is a tricyclic aryl derivative that acts as a competitive antagonist at the CB2 cannabinoid receptor.Acetylcholine receptorBRL-15,572Community-based clinical trial: Community-based clinical trials are clinical trials conducted directly through doctors and clinics rather than academic research facilities. They are designed to be administered through primary care physicians, community health centers and local outpatient facilities.Benzodiazepine misuse: The non-medical use of Benzodiazepine drugs (called misuse or abuse in public health journals) is the use of benzodiazepines without a prescription, often for recreational purposes, which poses risks of dependence, withdrawal and other long-term effects. Benzodiazepines are one of the more common prescription drugs used recreationally.Ethyl groupGraphic facilitation: Graphic Facilitation is the use of large scale imagery to lead groups and individuals towards a goal. The method is used in various processes such as meetings, seminars, workshops and conferences.Baby hamster kidney cell: Baby Hamster Kidney fibroblasts (aka BHK cells) are an adherent cell line used in molecular biology.Syllabus: A syllabus (pl. syllabi) is an outline and summary of topics to be covered in an education or training course.Phenylpiperidine: Phenylpiperidine is a chemical compound with a phenyl moiety directly attached to piperidine. There are a variety of pharmacological effects associated some phenylpiperidines including morphine-like activity or other central nervous system effects.BentazepamDavid Steinman: You may also be looking for David B. Steinman, builder of bridges.JWH-196: JWH-196 is a synthetic cannabinoid receptor ligand from the naphthoylindole family. It is the indole 2-methyl derivative of related compound JWH-175, and the carbonyl reduced analog of JWH-007.Drug interaction: A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own.Patch clamp: The patch clamp technique is a laboratory technique in electrophysiology that allows the study of single or multiple ion channels in cells. The technique can be applied to a wide variety of cells, but is especially useful in the study of excitable cells such as neurons, cardiomyocytes, muscle fibers, and pancreatic beta cells.BioSimMolecular modificationAllosteric regulationPiperoxanOpioid: Opioids are substances that act on the nervous system in a similar way to opiates such as morphine and codeine. In a medical context the term usually indicates medications that are artificially made rather than extracted from opium.PivagabineAntileukemic drug: Antileukemic drugs, anticancer drugs that are used to treat one or more types of leukemia, include:A. N. Hartley: Annie Norah Hartley (1902 – 1994), usually known simply as Norah Hartley, was a dog breeder and the first female board member of the Kennel Club.Journal of Medical Toxicology: The Journal of Medical Toxicology is a peer-reviewed medical journal on medical toxicology and the official journal of the American College of Medical Toxicology. It publishes original articles, illustrative cases, review articles, and other special features that are related to the clinical diagnosis and management of patients with exposure to various poisons.Reversal potential: In a biological membrane, the reversal potential (also known as the Nernst potential) of an ion is the membrane potential at which there is no net (overall) flow of that particular ion from one side of the membrane to the other. In the case of post-synaptic neurons, the reversal potential is the membrane potential at which a given neurotransmitter causes no net current flow of ions through that neurotransmitter receptor's ion channel.TerpyridineHSD2 neurons: HSD2 neurons are a small group of neurons in the brainstem which are uniquely sensitive to the mineralocorticosteroid hormone aldosterone, through expression of HSD11B2. They are located within the caudal medulla oblongata, in the nucleus of the solitary tract (NTS).Rosalyn Sussman YalowMitragyna: Mitragyna is a genus of trees in the Rubiaceae family. Members of this genus contain antimalarial and analgesic indole alkaloids.Burst kinetics: Burst kinetics is a form of enzyme kinetics that refers to an initial high velocity of enzymatic turnover when adding enzyme to substrate. This initial period of high velocity product formation is referred to as the "Burst Phase".Osmotic controlled-release oral delivery system: OROS (Osmotic [Controlled] Release Oral [Delivery] System) is a controlled release oral drug delivery system in the form of a tablet. The tablet has a rigid water-permeable jacket with one or more laser drilled small holes.Periodic current reversalCiproxifanNewington Green Unitarian ChurchNeural drug delivery systems: Neural drug delivery is the next step beyond the basic addition of growth factors to nerve guidance conduits. Drug delivery systems allow the rate of growth factor release to be regulated over time, which is critical for creating an environment more closely representative of in vivo development environments.Bath salts (drug): Bath salts is a term used in North America to describe a number of recreational designer drugs. The name derives from instances in which the drugs were sold disguised as true bath salts.Enlightenment Intensive: An Enlightenment Intensive is a group retreat designed to enable a spiritual enlightenment experience within a relatively short time. Devised by Americans Charles (1929–2007) and Ava Berner in the 1960s,http://www.Temporal analysis of products: Temporal Analysis of Products (TAP), (TAP-2), (TAP-3) is an experimental technique for studyingNonbenzodiazepine: Nonbenzodiazepines (sometimes referred to colloquially as "Z-drugs") are a class of psychoactive drugs that are very benzodiazepine-like in nature. Nonbenzodiazepines pharmacodynamics are almost entirely the same as benzodiazepine drugs and therefore employ similar benefits, side-effects, and risks.Calcium signaling: Calcium ions are important for cellular signalling, as once they enter the cytosol of the cytoplasm they exert allosteric regulatory effects on many enzymes and proteins. Calcium can act in signal transduction resulting from activation of ion channels or as a second messenger caused by indirect signal transduction pathways such as G protein-coupled receptors.Nicotine replacement therapyNihon UniversityCyclophane: 300px|right|Scheme 1. CyclophanesA cyclophane is a hydrocarbon consisting of an aromatic unit (typically a benzene ring) and an aliphatic chain that forms a bridge between two non-adjacent positions of the aromatic ring.CariprazinePharmaceutical manufacturing: Drug manufacturing is the process of industrial-scale synthesis of pharmaceutical drugs by pharmaceutical companies. The process of drug manufacturing can be broken down into a series of unit operations, such as milling, granulation, coating, tablet pressing, and others.Cannabinoid receptor antagonist: The discovery of the endogenous cannabinoid system led to the development of CB1 receptor antagonists. The first cannabinoid receptor antagonist, rimonabant, was described in 1994.Strychnine poisoning

(1/926) The pathologist and toxicologist in pharmaceutical product discovery.

Significant change is occurring in the drug discovery paradigm; many companies are utilizing dedicated groups from the toxicology/ pathology disciplines to support early stage activities. The goal is to improve the efficiency of the discovery process for selecting a successful clinical candidate. Toxicity can be predicted by leveraging molecular techniques via rapid high-throughput, low-resource in vitro and in vivo test systems. Several important activities help create a platform to support rapid development of a new molecular entity. The proceedings of this symposium provide excellent examples of these applied concepts in pharmaceutical research and development. Leading biopharmaceutical companies recognize that a competitive advantage can be maintained via rapid characterization of animal models, the cellular identification of therapeutic targets, and improved sensitivity of efficacy assessment. The participation of the molecular pathologist in this quest is evolving rapidly, as evidenced by the growing number of pathologists that interact with drug discovery organizations.  (+info)

(2/926) PET and drug research and development.

The use of PET to examine the behavioral, therapeutic and toxic properties of drugs and substances of abuse is emerging as a powerful new scientific tool. PET provides a new perspective on drug research by virtue of its ability to directly assess both pharmacokinetic and pharmacodynamic events in humans and in animals. These parameters can be assessed directly in the human body both in healthy volunteers and in patients. Moreover, the new generation of high-resolution, small-animal cameras hold the promise of introducing imaging in the early stages of drug development and make it possible to carry out longitudinal studies in animals and to study genetically altered animals. This places PET in a unique position to contribute significantly to the process of drug development through understanding the molecular mechanisms underlying drug action while addressing some very practical questions such as determining effective drug doses for clinical trials for new drugs, determining the duration of drug action and examining potential drug interactions.  (+info)

(3/926) The pharmacology of gene therapy.

The objective for human gene therapy is to express exogenous DNA at a site in vivo for long enough, and at sufficient levels to produce a therapeutic response. The obstacles to this objective are numerous and include the formulation or packaging of the DNA, in vivo delivery, penetration of biological barriers, DNA elimination within the cell and from the tissue compartments of the whole body, control of product expression and overt toxicity. The current challenge is to resolve each of these obstacles to produce a practical and efficient gene therapy. In doing so, it is vital to understand the disposition of DNA vectors in vivo, and to know how conventional medicines may be used to modulate this disposition and to enhance the therapeutic effect of these vectors. Many of the general concepts of human gene therapy have been reviewed extensively in the literature. This review discusses some of the pharmacological aspects of gene delivery and the fate of vectors in vivo, and then highlights how drugs are being used to modulate gene therapy.  (+info)

(4/926) Is orphan drug status beneficial to tropical disease control? Comparison of the American and future European orphan drug acts.

OBJECTIVES To quantify past outcomes of tropical pharmacology research and development (R & D) and to assess past benefits of the American orphan drug act and potential benefits of the future European orphan drug regulation on tropical diseases. METHODS: This paper presents two analyses: a 1983-97 retrospective study of the United States Orphan Drug Act concerning rare diseases and a prospective study of the European Proposal for a Regulation Concerning Orphan Drugs and its possible impact on tropical diseases. RESULTS: Different programmes have in the past tried to stimulate R & D in this area, but results remain limited. Of 1450 new chemical entities marketed between 1972 and 1997, 13 were specifically for tropical diseases and considered as essential drugs. Between 1983 & 1997, the US Orphan Drug Act approved 837 drugs and marketing of 152 new molecular entities (NMEs). Three NMEs have been designated for malaria and human African trypanosomiasis. Seven others, already commonly used in tropical diseases, received either orphan designation or an orphan approval for another indication. Pharmaceutical companies benefit from the US framework only when the US market exclusivity clause was applicable. Future European orphan drug regulation appears to be similar to the US Orphan Drug Act. CONCLUSION The orphan drug programmes relating to rare diseases have met with some success. Considering tropical diseases rare diseases seems inadequate to boost pharmaceutical R & D. However, some provisions of the European text may be relevant to tropical diseases, admitting the need for a more specific rule for evaluations of this kind of drug and recognizing the existence of 'diseases of exception'.  (+info)

(5/926) A comparison of the direct and reporter antigen popliteal lymph node assay for the detection of immunomodulation by low molecular weight compounds.

The direct popliteal lymph node assay (PLNA) is a predictive test used to detect the immune-stimulating potential of pharmaceuticals and other low molecular weight compounds (LMWCs) with known autoimmunogenic or sensitizing properties. Two limitations in the PLNA are the existence of false negatives and the inability of the assay to provide mechanistic information. Recently the direct PLNA was modified by incorporating reporter antigens (RA), either TNP-Ficoll or TNP-OVA. In the RA-PLNA, immune stimulation is detected by measuring IgM or IgG TNP-specific antibody-forming cells (AFC) using an enzyme-linked immunospot (ELISPOT) assay. The RA-PLNA, when using potent, known autoimmunogenic compounds, may provide greater sensitivity compared to the direct PLNA and might distinguish LMWCs that have intrinsic adjuvant activity from those that create neo-antigens, using TNP-OVA and TNP-Ficoll, respectively. The purpose of this study was to rigorously compare the two assays. Our first objective was to investigate the interlaboratory reproducibility of the RA-PLNA using four autoimmunogenic LMWC models, plus one negative control LMWC. Subsequently, we tested seven LMWCs with known sensitizing properties and compared the results from the direct and modified assay. The test group included LMWCs thought to be mechanistically distinct and similar to compounds typically encountered in preclinical safety assessment. All control and treatment AFC plaques were collected (76 total), pooled, coded to conceal their source, and counted. The interlaboratory reproducibility of the RA-PLNA was demonstrated with the model autoimmunogenic compounds HgCl2, diphenylhydantoin, D-penicillamine, and the negative control compound phenobarbital, by detecting TNP-specific IgM and polyclonal IgG production to both reporter antigens. Additionally, the sensitizing effects of streptozotocin were identified using an IgG2a ELISPOT with both TNP-OVA and TNP-Ficoll. With the extended test group, the sensitizing effects of aniline, a false negative LMWC in the direct PLNA, was not detected in this study when using the direct PLNA. However, there was an increase of IgG1 AFCs using TNP-OVA, when compared to control (508 +/- 113 vs. 12 +/- 4 respectively). Glafenine, diclofenac, and ibuprofen, all associated with drug-induced anaphylaxis in humans, produced significant increases in IgG1 production to TNP-OVA. Of these three LMWCs, only diclofenac, which has been documented to induce neo-antigen formation, was detected with TNP-Ficoll. Hydralazine immunomodulation could be detected only with the direct PLNA although significant increases in IgM were identified with the co-injection of either reporter antigen. Isoniazid and methyldopa consistently produced negative responses in both assays. In summary, this study has demonstrated acceptable interlaboratory reproducibility of the RA-PLNA, using model autoimmunogenic LMWCs. Additionally, it demonstrated that an advantage of the RA-PLNA was that it identified all anaphylactic-associated LMWCs tested, detected the false negative compound aniline, and revealed what is thought to be the mechanism(s) associated with diclofenac-induced immunostimulation.  (+info)

(6/926) Effects of drugs on glucose measurements with handheld glucose meters and a portable glucose analyzer.

Thirty drugs used primarily in critical care and hospital settings were tested in vitro to observe interference on glucose measurements with 6 hand-held glucose meters and a portable glucose analyzer. Paired differences of glucose measurements between drug-spiked samples and unspiked control samples were calculated to determine bias. A criterion of +/- 6 mg/dL was used as the cutoff for interference. Ascorbic acid interfered with the measurements on all glucose devices evaluated. Acetaminophen, dopamine, and mannitol interfered with glucose measurements on some devices. Dose-response relationships help assessment of drug interference in clinical use. High dosages of these drugs may be given to critically ill patients or self-administered by patients without medical supervision. Package inserts for the glucose devices may not provide adequate warning information. Hence, we recommend that clinicians choose glucose devices carefully and interpret results cautiously when glucose measurements are performed during or after drug interventions.  (+info)

(7/926) International union of pharmacology. XXII. Nomenclature for chemokine receptors.

Chemokine receptors comprise a large family of seven transmembrane domain G protein-coupled receptors differentially expressed in diverse cell types. Biological activities have been most clearly defined in leukocytes, where chemokines coordinate development, differentiation, anatomic distribution, trafficking, and effector functions and thereby regulate innate and adaptive immune responses. Pharmacological analysis of chemokine receptors is at an early stage of development. Disease indications have been established in human immunodeficiency virus/acquired immune deficiency syndrome and in Plasmodium vivax malaria, due to exploitation of CCR5 and Duffy, respectively, by the pathogen for cell entry. Additional indications are emerging among inflammatory and immunologically mediated diseases, but selection of targets in this area still remains somewhat speculative. Small molecule antagonists with nanomolar affinity have been reported for 7 of the 18 known chemokine receptors but have not yet been studied in clinical trials. Virally encoded chemokine receptors, as well as chemokine agonists and antagonists, and chemokine scavengers have been identified in medically important poxviruses and herpesviruses, again underscoring the importance of the chemokine system in microbial pathogenesis and possibly identifying specific strategies for modulating chemokine action therapeutically. The purpose of this review is to update current concepts of the biology and pharmacology of the chemokine system, to summarize key information about each chemokine receptor, and to describe a widely accepted receptor nomenclature system, ratified by the International Union of Pharmacology, that is facilitating clear communication in this area.  (+info)

(8/926) Mechanisms mediating substance P-induced contraction in the rat iris in vitro.

PURPOSE: To determine some of the mechanisms by which substance P (SP) induces contraction in the isolated rat iris. METHODS: Rings of rat iris were mounted in a 5-ml organ chamber containing Krebs solution at 37 degrees C under basal tension of 75 mg, and isometric tension was recorded. RESULTS: Substance P produced graded contraction in the rat iris, being approximately 40-fold more potent than carbachol. Peptidase inhibitors (captopril, phosphoramidon, thiorphan) did not affect the SP response. The SP contraction was dependent on external Ca2+ by a mechanism resistant to both nifedipine and omega-conotoxin GVIA. Atropine and tetrodotoxin significantly shifted the SP response to the right (three- and fivefold, respectively). Neither phorbol nor genistein altered the SP-induced contraction, whereas staurosporine caused a weak inhibition. Indomethacin, pyrilamine, guanethidine, 8-37 calcitonin gene-related peptide (CGRP) fragment, and NG-nitro-L-arginine methyl ester had no effect on SP response. All the natural tachykinin agonists caused concentration-dependent contraction in rat iris with similar maximal responses. The NK3 selective agonist senktide caused graded contraction, being approximately 150-fold more active than the NK2 selective agonist [beta-ala] NKA. The NK1 selective agonist SP methyl ester induced a small contraction. The NK3 and NK2 antagonists SR 142801 and SR 48968 shifted the SP response to the right. Schilds plots gave pA2 (negative logarithm of the molar concentration of antagonist causing a twofold rightward displacement of the concentration response curves) values of 9.37 and 7.97 and slopes of 0.70 and 1.02, respectively. CONCLUSIONS: Substance P produces a potent contraction in the isolated rat iris that seems to depend on the neural release of acetylcholine by tetrodotoxin-sensitive mechanisms. Its response relies largely on external Ca2+, through mechanisms independent of activation of L- or N-type Ca2+ channels, and is probably mediated via activation of NK3 and NK2 receptors.  (+info)


Molecular Pharmacology


  • Thank you for sharing this Molecular Pharmacology article. (aspetjournals.org)
  • Prior to coming to Yale University, he was Professor in the Department of Chemistry at UC Berkeley and jointly held a faculty position in the Department of Cellular and Molecular Pharmacology at UC San Francisco. (yale.edu)


therapeutics


  • I recently attended a meeting at the Medicines and Healthcare Products Regulatory Agency and a clinical pharmacology colloquium with a large number of specialist registrars in clinical pharmacology and therapeutics. (bmj.com)
  • Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article. (aspetjournals.org)
  • Message Body (Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics. (aspetjournals.org)
  • The International Journal of Clinical Pharmacology and Therapeutics appears monthly and publishes manuscripts containing original material with emphasis on the following topics: Clinical trials, Pharmacoepidemiology - Pharmacovigilance, Pharmacodynamics, Drug disposition and Pharmacokinetics, Quality assurance, Pharmacogenetics, Biotechnological drugs such as cytokines and recombinant antibiotics. (procon.org)


Physiology


  • The program of study includes graduate level courses in pharmacology, physiology, biochemistry, and statistics. (osu.edu)


2017


  • Lane Wallace, PhD, Has recently (2017) assumed a faculty position as Lecturer in the Division of Pharmacology at The Ohio State University College of Pharmacy. (osu.edu)


Biology


  • Nam Lee, PhD, Presently a Posdoctoral Research Associate in the Department of Pharmacology and Cancer Biology, Duke University School of Medicine, working in the laboratory of Dr. Xiao-Fan Wang. (osu.edu)


Editor-in-Ch


  • The proposal of thematic issue will then be immediately forwarded to the Editor-in-Chief/Co-Editors/Executive Editor(s) of Current Clinical Pharmacology who will then inform Guest Editors with a decision about the submitted proposal. (benthamscience.com)


Department


  • Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington (W.A.C. (aspetjournals.org)
  • Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee (P.J.C. (aspetjournals.org)
  • Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina (T.K.H. (aspetjournals.org)


Issue


  • Guest Editors who wish to submit an issue proposal to Current Clinical Pharmacology are requested to complete the following online form. (benthamscience.com)


drug


  • A PhD in Pharmaceutical Sciences with an emphasis in Pharmacology immerses a student in discovering the mechanisms of drug action, using drugs as tools to explore the workings of the body, and studying disease models to find new drug targets. (osu.edu)


knowledge


  • This classroom-based, facilitator-led course is designed to improve electrocardiogram (ECG) recognition skills and pharmacology knowledge for treating cardiovascular emergencies. (barnabashealth.org)


years


  • A policy statement in the British Journal of Clinical Pharmacology more than 30 years ago defined the role of the clinical pharmacologist in the district general hospital. (bmj.com)
  • The Association of the British Pharmaceutical Industry's guidelines for phase I clinical trials suggest that those individuals who act as principal investigators should have specific qualifications, including a certificate of completion of clinical training in clinical pharmacology and a minimum of two years' phase I experience. (bmj.com)


course


  • Ocular pharmacology is a blended learning course. (neco.edu)


Program


  • added 'See the links at the left to find out more about the graduate program in pharmacology' per Dale Hoyt's request. (osu.edu)


What's the difference between PHARMACY, PHARMACOLOGY and PHARMACEUTICS?


  • Do they bascially mean the same thing? And do university courses in pharmacy and pharmacology teach the same stuff?
  • Pharmacology and Pharmaceutics are basically the same thing. Pharmacology is the study of the metabolism of drugs in the body, and Pharmaceutics is the study of the chemical compounding of medicine. Pharmacy, depending on the way it is put, is just the general aspect of Pharmaceuticals. As far as the university courses, you need to check with your counselor on that. Different classes have different curriculums.


What kind of patients will I see on a pharmacology ward?


  • I'm starting my first placement (adult nursing) on a pharmacology ward. After briefly speaking to a member of staff I was told it will be "overdoses and stuff". Can anybody give me information on what the "and stuff" might be?
  • Anything related to drugs, their misuse, overdose, and intense side effects.


what are the different divisions of pharmacology?


  • thank you very much for the response. im glad that you give time for my question. GOD BLESS.
  • duh what?


whats the difference between pharmacology and pharmacy programs?


  • i really want to learn about drugs and their affects on the body but this inst something im looking to do as a career. which one do you think is best for me?
  • Pharmacology is a pharmaceutical science: it is the study of drugs and medications. It breaks down the usage, dosages, side effects, formulations... ect of medications. I only know people that have Ph.Ds in pharmacology ie my pharmacology professors. With this you can teach at a pharmacy school or probably work for the CDC. Pharmacy is a 6 year doctorate degree that incompasses pharmacology as two classes. To be a licensed practicing pharmacist in the U.S you must have the PharmD.(doctor of Pharmacy) degree. So best bet would be to become a pharmacist there over 60 career path ways that a pharmacist can choose from and they are considered the medication expert . Nuclear Pharmacy, forensic pharmacy, clinical Pharmacy- oncology, pediatrics....., etc and ofcourse what most people associate pharmacy with...retail pharmacy ie walgreens, publix , CVS, Walmart ...ect


Where can I learn pharmacology online for free?


  • I have been a clinical tech in the ER for 3 years and have alot of experience but a new job is being offered to me in a doctors office and it requires that I do IM injections. I am nervous because I have never done them. I have witness it several times but never done them (nurses job). I am not nervouse about the sites being chosen I am nervous about correct dosing and making sure I choose the right muscle. HELP!!
  • I've enclosed a link for a book that covers everything about online pharmacology education. Injections IM are not that difficult to do, knowing exactly where to place the needle is the most important thing. You can practice Doing injections using an orange. That's the way they usually teach you how to do it in school. I think it's going to be difficult to learn this online.


What is the diffference between pharmacy and pharmacology?


what are some healing rituals related to pharmacology?


  • Rituals can be from any cultures and any religion.
  • I think I'm misunderstanding your question... there are no cultural rituals in pharmacology. http://dictionary.reference.com/browse/pharmacology lists pharmacology as "the science dealing with the preparation, uses, and esp. the effects of drugs"... it has nothing to do with cultures, herbs, or anything other than the commonly chemically-produced drugs. The only "rituals" that would take place would be for cleaning/sanitation purposes. Is there something else in particular you're trying to ask?


I want a subject for a presentation for general pharmacology?


  • Hi! Can somebody help! I have to choice a subject for a apresentation (that teacher didn't explain). But the porfessor have acepted sujects like self medication, placebo, Thinning tablets (clear that i can no longer use this ones: ( ) . If anyone can help, Thank you :)
  • Pick a commonly used herbal over the counter med and research effects it can have on some doctor prescribed pills. Many doctors do not ask about herbals that a patient may be taking and reactions can be mild to severe and can actually cause death. Very interesting topic I think.