The process by which PAIN is recognized and interpreted by the brain.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Amount of stimulation required before the sensation of pain is experienced.
The process by which the nature and meaning of sensory stimuli are recognized and interpreted.
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
Peripheral AFFERENT NEURONS which are sensitive to injuries or pain, usually caused by extreme thermal exposures, mechanical forces, or other noxious stimuli. Their cell bodies reside in the DORSAL ROOT GANGLIA. Their peripheral terminals (NERVE ENDINGS) innervate target tissues and transduce noxious stimuli via axons to the CENTRAL NERVOUS SYSTEM.
A form of therapy that employs a coordinated and interdisciplinary approach for easing the suffering and improving the quality of life of those experiencing pain.
Aching sensation that persists for more than a few months. It may or may not be associated with trauma or disease, and may persist after the initial injury has healed. Its localization, character, and timing are more vague than with acute pain.
Dull or sharp aching pain caused by stimulated NOCICEPTORS due to tissue injury, inflammation or diseases. It can be divided into somatic or tissue pain and VISCERAL PAIN.
Pain during the period after surgery.
Pain in the facial region including orofacial pain and craniofacial pain. Associated conditions include local inflammatory and neoplastic disorders and neuralgic syndromes involving the trigeminal, facial, and glossopharyngeal nerves. Conditions which feature recurrent or persistent facial pain as the primary manifestation of disease are referred to as FACIAL PAIN SYNDROMES.
Sensing of noxious mechanical, thermal or chemical stimuli by NOCICEPTORS. It is the sensory component of visceral and tissue pain (NOCICEPTIVE PAIN).
The sensation of cold, heat, coolness, and warmth as detected by THERMORECEPTORS.
A syndrome characterized by indifference to PAIN despite the ability to distinguish noxious from non-noxious stimuli. Absent corneal reflexes and INTELLECTUAL DISABILITY may be associated. Familial forms with autosomal recessive and autosomal dominant patterns of inheritance have been described. (Adams et al., Principles of Neurology, 6th ed, p1343)
Methods of PAIN relief that may be used with or in place of ANALGESICS.
Acute or chronic pain in the lumbar or sacral regions, which may be associated with musculo-ligamentous SPRAINS AND STRAINS; INTERVERTEBRAL DISK DISPLACEMENT; and other conditions.
An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve.
Compounds capable of relieving pain without the loss of CONSCIOUSNESS.
The selecting and organizing of visual stimuli based on the individual's past experience.
Act of eliciting a response from a person or organism through physical contact.
The minimum amount of stimulus energy necessary to elicit a sensory response.
Acute or chronic pain located in the posterior regions of the THORAX; LUMBOSACRAL REGION; or the adjacent regions.
Presence of warmth or heat or a temperature notably higher than an accustomed norm.
The real or apparent movement of objects through the visual field.
The electric response evoked in the CEREBRAL CORTEX by stimulation along AFFERENT PATHWAYS from PERIPHERAL NERVES to CEREBRUM.
The perceiving of attributes, characteristics, and behaviors of one's associates or social groups.
The process whereby an utterance is decoded into a representation in terms of linguistic units (sequences of phonetic segments which combine to form lexical and grammatical morphemes).
A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
Sensation of discomfort, distress, or agony in the abdominal region.
An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.
Discomfort or more intense forms of pain that are localized to the cervical region. This term generally refers to pain in the posterior or lateral regions of the neck.
Persistent pain that is refractory to some or all forms of treatment.
Drugs that act on neuronal sensory receptors resulting in an increase, decrease, or modification of afferent nerve activity. (From Smith and Reynard, Textbook of Pharmacology, 1991, p367)
A 31-amino acid peptide that is the C-terminal fragment of BETA-LIPOTROPIN. It acts on OPIOID RECEPTORS and is an analgesic. Its first four amino acids at the N-terminal are identical to the tetrapeptide sequence of METHIONINE ENKEPHALIN and LEUCINE ENKEPHALIN.
Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
The process in which specialized SENSORY RECEPTOR CELLS transduce peripheral stimuli (physical or chemical) into NERVE IMPULSES which are then transmitted to the various sensory centers in the CENTRAL NERVOUS SYSTEM.
Pain in the pelvic region of genital and non-genital origin and of organic or psychogenic etiology. Frequent causes of pain are distension or contraction of hollow viscera, rapid stretching of the capsule of a solid organ, chemical irritation, tissue ischemia, and neuritis secondary to inflammatory, neoplastic, or fibrotic processes in adjacent organs. (Kase, Weingold & Gershenson: Principles and Practice of Clinical Gynecology, 2d ed, pp479-508)
Area of the parietal lobe concerned with receiving sensations such as movement, pain, pressure, position, temperature, touch, and vibration. It lies posterior to the central sulcus.
Perception of three-dimensionality.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
Analgesia produced by the insertion of ACUPUNCTURE needles at certain ACUPUNCTURE POINTS on the body. This activates small myelinated nerve fibers in the muscle which transmit impulses to the spinal cord and then activate three centers - the spinal cord, midbrain and pituitary/hypothalamus - to produce analgesia.
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
A class of nerve fibers as defined by their nerve sheath arrangement. The AXONS of the unmyelinated nerve fibers are small in diameter and usually several are surrounded by a single MYELIN SHEATH. They conduct low-velocity impulses, and represent the majority of peripheral sensory and autonomic fibers, but are also found in the BRAIN and SPINAL CORD.
ANGINA PECTORIS or angina-like chest pain with a normal coronary arteriogram and positive EXERCISE TEST. The cause of the syndrome is unknown. While its recognition is of clinical importance, its prognosis is excellent. (Braunwald, Heart Disease, 4th ed, p1346; Jablonski Dictionary of Syndromes & Eponymic Diseases, 2d ed). It is different from METABOLIC SYNDROME X, a syndrome characterized by INSULIN RESISTANCE and HYPERINSULINEMIA, that has increased risk for cardiovascular disease.
Intensely discomforting, distressful, or agonizing sensation associated with trauma or disease, with well-defined location, character, and timing.
The process whereby auditory stimuli are selected, organized, and interpreted by the organism.
Enzyme that catalyzes the movement of a methyl group from S-adenosylmethionone to a catechol or a catecholamine.
Nerve structures through which impulses are conducted from a peripheral part toward a nerve center.
An absence of warmth or heat or a temperature notably below an accustomed norm.
A common nonarticular rheumatic syndrome characterized by myalgia and multiple points of focal muscle tenderness to palpation (trigger points). Muscle pain is typically aggravated by inactivity or exposure to cold. This condition is often associated with general symptoms, such as sleep disturbances, fatigue, stiffness, HEADACHES, and occasionally DEPRESSION. There is significant overlap between fibromyalgia and the chronic fatigue syndrome (FATIGUE SYNDROME, CHRONIC). Fibromyalgia may arise as a primary or secondary disease process. It is most frequent in females aged 20 to 50 years. (From Adams et al., Principles of Neurology, 6th ed, p1494-95)
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
A type of pain that is perceived in an area away from the site where the pain arises, such as facial pain caused by lesion of the VAGUS NERVE, or throat problem generating referred pain in the ear.
The sensory discrimination of a pattern shape or outline.
An optical source that emits photons in a coherent beam. Light Amplification by Stimulated Emission of Radiation (LASER) is brought about using devices that transform light of varying frequencies into a single intense, nearly nondivergent beam of monochromatic radiation. Lasers operate in the infrared, visible, ultraviolet, or X-ray regions of the spectrum.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717)
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Elements of limited time intervals, contributing to particular results or situations.
Those affective states which can be experienced and have arousing and motivational properties.
An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Unilateral or bilateral pain of the shoulder. It is often caused by physical activities such as work or sports participation, but may also be pathologic in origin.
A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The ability to estimate periods of time lapsed or duration of time.
Discomfort stemming from muscles, LIGAMENTS, tendons, and bones.
The feeling-tone accompaniment of an idea or mental representation. It is the most direct psychic derivative of instinct and the psychic representative of the various bodily changes by means of which instincts manifest themselves.
The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.
The time from the onset of a stimulus until a response is observed.
Feeling or emotion of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
The observable response an animal makes to any situation.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain.
A dimension of auditory sensation varying with cycles per second of the sound stimulus.
The process by which the nature and meaning of gustatory stimuli are recognized and interpreted by the brain. The four basic classes of taste perception are salty, sweet, bitter, and sour.
The science dealing with the correlation of the physical characteristics of a stimulus, e.g., frequency or intensity, with the response to the stimulus, in order to assess the psychologic factors involved in the relationship.
Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
The awareness of the spatial properties of objects; includes physical space.
Use of electric potential or currents to elicit biological responses.
The process by which the nature and meaning of tactile stimuli are recognized and interpreted by the brain, such as realizing the characteristics or name of an object being touched.
Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.
The sensory interpretation of the dimensions of objects.
Investigative technique commonly used during ELECTROENCEPHALOGRAPHY in which a series of bright light flashes or visual patterns are used to elicit brain activity.
A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
Mental processing of chromatic signals (COLOR VISION) from the eye by the VISUAL CORTEX where they are converted into symbolic representations. Color perception involves numerous neurons, and is influenced not only by the distribution of wavelengths from the viewed object, but also by its background color and brightness contrast at its boundary.
The process by which the nature and meaning of olfactory stimuli, such as odors, are recognized and interpreted by the brain.
The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.
A subgroup of TRP cation channels named after vanilloid receptor. They are very sensitive to TEMPERATURE and hot spicy food and CAPSAICIN. They have the TRP domain and ANKYRIN repeats. Selectivity for CALCIUM over SODIUM ranges from 3 to 100 fold.
A class of opioid receptors recognized by its pharmacological profile. Mu opioid receptors bind, in decreasing order of affinity, endorphins, dynorphins, met-enkephalin, and leu-enkephalin. They have also been shown to be molecular receptors for morphine.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Public attitudes toward health, disease, and the medical care system.
Stress wherein emotional factors predominate.
Knowledge, attitudes, and associated behaviors which pertain to health-related topics such as PATHOLOGIC PROCESSES or diseases, their prevention, and treatment. This term refers to non-health workers and health workers (HEALTH PERSONNEL).
Those characteristics that distinguish one SEX from the other. The primary sex characteristics are the OVARIES and TESTES and their related hormones. Secondary sex characteristics are those which are masculine or feminine but not directly related to reproduction.
Attitudes of personnel toward their patients, other professionals, toward the medical care system, etc.
Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM.
Recognition and discrimination of the heaviness of a lifted object.
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
Neural tracts connecting one part of the nervous system with another.
The misinterpretation of a real external, sensory experience.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
Differential response to different stimuli.

Pain sensitivity and neural processing during dissociative states in patients with borderline personality disorder with and without comorbid posttraumatic stress disorder: a pilot study. (1/216)

BACKGROUND: Stress-induced dissociative states involving analgesia are a common feature of borderline personality disorder (BPD) and posttraumatic stress disorder (PTSD). Our aim was to investigate the psychologic, somatosensory (pain sensitivity) and neural correlates of dissociative states in patients with these disorders. METHODS: We included 15 women with BPD who were not taking medication; 10 of these women had comorbid PTSD. While undergoing functional magnetic resonance imaging at 1.5 Tesla, participants were exposed to a script describing a personalized dissociation-inducing situation and a personalized script describing a neutral situation. We assessed dissociative psychopathology and pain sensitivity. RESULTS: Dissociative psychopathology scores were significantly higher and pain sensitivity was lower after the dissociation-inducing script was read compared with the neutral script. The blood oxygen level-dependent (BOLD) signal was significantly increased in the left inferior frontal gyrus (Brodmann area [BA] 9) during the presentation of the dissociation-inducing script. Regression analyses revealed positive correlations between BOLD signal and dissociative psychopathology in the left superior frontal gyrus (BA 6) and negative correlations in the right middle (BA 21) and inferior temporal gyrus (BA 20). In the subgroup of participants with comorbid PTSD, we also found increased activity in the left cingulate gyrus (BA 32) during script-driven imagery-induced dissociation, a positive correlation between dissociation scores and activity in the right and left insula (BA 13) and a negative correlation in the right parahippocampal gyrus (BA 35). LIMITATIONS: The main limitation of this pilot study is the absence of a control group. Therefore, the results may also reflect the neural correlates of non-BPD/PTSD specific dissociative states or the neural correlates of emotionally stressful or "loaded" memories. Another limitation is the uncorrected statistical level of the functional magnetic resonance imaging results. CONCLUSION: Our results showed that the script-driven imagery method is capable of inducing dissociative states in participants with BPD with and without comorbid PTSD. These states were characterized by reduced pain sensitivity and a frontolimbic activation pattern, which resembles the findings in participants with PTSD while in dissociative states.  (+info)

The cerebellum and pain: passive integrator or active participator? (2/216)

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Videogame distraction using virtual reality technology for children experiencing cold pressor pain: the role of cognitive processing. (3/216)

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Two novel mutations of SCN9A (Nav1.7) are associated with partial congenital insensitivity to pain. (4/216)

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Flexible cerebral connectivity patterns subserve contextual modulations of pain. (5/216)

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Enteric nervous system in the small intestine: pathophysiology and clinical implications. (6/216)

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Multiple somatotopic representations of heat and mechanical pain in the operculo-insular cortex: a high-resolution fMRI study. (7/216)

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The relationship of demographic and psychosocial variables to pain-related outcomes in a rural chronic pain population. (8/216)

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Pain perception refers to the neural and psychological processes involved in receiving, interpreting, and responding to painful stimuli. It is the subjective experience of pain, which can vary greatly among individuals due to factors such as genetics, mood, expectations, and past experiences. The perception of pain involves complex interactions between the peripheral nervous system (which detects and transmits information about tissue damage or potential harm), the spinal cord (where this information is processed and integrated with other sensory inputs), and the brain (where the final interpretation and emotional response to pain occurs).

Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. It is a complex phenomenon that can result from various stimuli, such as thermal, mechanical, or chemical irritation, and it can be acute or chronic. The perception of pain involves the activation of specialized nerve cells called nociceptors, which transmit signals to the brain via the spinal cord. These signals are then processed in different regions of the brain, leading to the conscious experience of pain. It's important to note that pain is a highly individual and subjective experience, and its perception can vary widely among individuals.

Pain threshold is a term used in medicine and research to describe the point at which a stimulus begins to be perceived as painful. It is an individual's subjective response and can vary from person to person based on factors such as their pain tolerance, mood, expectations, and cultural background.

The pain threshold is typically determined through a series of tests where gradually increasing levels of stimuli are applied until the individual reports feeling pain. This is often used in research settings to study pain perception and analgesic efficacy. However, it's important to note that the pain threshold should not be confused with pain tolerance, which refers to the maximum level of pain a person can endure.

In the context of medicine and psychology, perception refers to the neurophysiological processes, cognitive abilities, and psychological experiences that enable an individual to interpret and make sense of sensory information from their environment. It involves the integration of various stimuli such as sight, sound, touch, taste, and smell to form a coherent understanding of one's surroundings, objects, events, or ideas.

Perception is a complex and active process that includes attention, pattern recognition, interpretation, and organization of sensory information. It can be influenced by various factors, including prior experiences, expectations, cultural background, emotional states, and cognitive biases. Alterations in perception may occur due to neurological disorders, psychiatric conditions, sensory deprivation or overload, drugs, or other external factors.

In a clinical setting, healthcare professionals often assess patients' perceptions of their symptoms, illnesses, or treatments to develop individualized care plans and improve communication and adherence to treatment recommendations.

Pain measurement, in a medical context, refers to the quantification or evaluation of the intensity and/or unpleasantness of a patient's subjective pain experience. This is typically accomplished through the use of standardized self-report measures such as numerical rating scales (NRS), visual analog scales (VAS), or categorical scales (mild, moderate, severe). In some cases, physiological measures like heart rate, blood pressure, and facial expressions may also be used to supplement self-reported pain ratings. The goal of pain measurement is to help healthcare providers better understand the nature and severity of a patient's pain in order to develop an effective treatment plan.

Nociceptors are specialized peripheral sensory neurons that detect and transmit signals indicating potentially harmful stimuli in the form of pain. They are activated by various noxious stimuli such as extreme temperatures, intense pressure, or chemical irritants. Once activated, nociceptors transmit these signals to the central nervous system (spinal cord and brain) where they are interpreted as painful sensations, leading to protective responses like withdrawing from the harmful stimulus or seeking medical attention. Nociceptors play a crucial role in our perception of pain and help protect the body from further harm.

Pain management is a branch of medicine that focuses on the diagnosis and treatment of pain and improvement in the quality of life of patients with chronic pain. The goal of pain management is to reduce pain levels, improve physical functioning, and help patients cope mentally and emotionally with their pain. This may involve the use of medications, interventional procedures, physical therapy, psychological therapy, or a combination of these approaches.

The definition of pain management can vary depending on the medical context, but it generally refers to a multidisciplinary approach that addresses the complex interactions between biological, psychological, and social factors that contribute to the experience of pain. Pain management specialists may include physicians, nurses, physical therapists, psychologists, and other healthcare professionals who work together to provide comprehensive care for patients with chronic pain.

Chronic pain is defined as pain that persists or recurs for a period of 3 months or longer, beyond the normal healing time for an injury or illness. It can be continuous or intermittent and range from mild to severe. Chronic pain can have various causes, such as nerve damage, musculoskeletal conditions, or chronic diseases like cancer. It can significantly impact a person's quality of life, causing limitations in mobility, sleep disturbances, mood changes, and decreased overall well-being. Effective management of chronic pain often involves a multidisciplinary approach, including medications, physical therapy, psychological interventions, and complementary therapies.

Nociceptive pain is a type of pain that results from the activation of nociceptors, which are specialized sensory receptors located in various tissues throughout the body. These receptors detect potentially harmful stimuli such as extreme temperatures, pressure, or chemical irritants and transmit signals to the brain, which interprets them as painful sensations.

Nociceptive pain can be further classified into two categories:

1. Somatic nociceptive pain: This type of pain arises from the activation of nociceptors in the skin, muscles, bones, and joints. It is often described as sharp, aching, or throbbing and may be localized to a specific area of the body.
2. Visceral nociceptive pain: This type of pain arises from the activation of nociceptors in the internal organs, such as the lungs, heart, and digestive system. It is often described as deep, cramping, or aching and may be more diffuse and difficult to localize.

Examples of conditions that can cause nociceptive pain include injuries, arthritis, cancer, and infections. Effective management of nociceptive pain typically involves a multimodal approach that includes pharmacologic interventions, such as non-opioid analgesics, opioids, and adjuvant medications, as well as non-pharmacologic therapies, such as physical therapy, acupuncture, and cognitive-behavioral therapy.

Postoperative pain is defined as the pain or discomfort experienced by patients following a surgical procedure. It can vary in intensity and duration depending on the type of surgery performed, individual pain tolerance, and other factors. The pain may be caused by tissue trauma, inflammation, or nerve damage resulting from the surgical intervention. Proper assessment and management of postoperative pain is essential to promote recovery, prevent complications, and improve patient satisfaction.

Facial pain is a condition characterized by discomfort or pain felt in any part of the face. It can result from various causes, including nerve damage or irritation, injuries, infections, dental problems, migraines, or sinus congestion. The pain can range from mild to severe and may be sharp, dull, constant, or intermittent. In some cases, facial pain can also be associated with other symptoms such as headaches, redness, swelling, or changes in sensation. Accurate diagnosis and treatment of the underlying cause are essential for effective management of facial pain.

Nociception is the neural process of encoding and processing noxious stimuli, which can result in the perception of pain. It involves the activation of specialized nerve endings called nociceptors, located throughout the body, that detect potentially harmful stimuli such as extreme temperatures, intense pressure, or tissue damage caused by chemicals released during inflammation. Once activated, nociceptors transmit signals through sensory neurons to the spinal cord and then to the brain, where they are interpreted as painful experiences.

It is important to note that while nociception is necessary for pain perception, it does not always lead to conscious awareness of pain. Factors such as attention, emotion, and context can influence whether or not nociceptive signals are experienced as painful.

Thermosensing refers to the ability of living organisms to detect and respond to changes in temperature. This is achieved through specialized proteins called thermosensors, which are capable of converting thermal energy into chemical or electrical signals that can be interpreted by the organism's nervous system. Thermosensing plays a critical role in regulating various physiological processes, such as body temperature, metabolism, and development. In medicine, understanding thermosensing mechanisms can provide insights into the treatment of conditions associated with impaired temperature regulation, such as fever or hypothermia.

Congenital pain insensitivity, also known as congenital analgesia, is a rare genetic disorder characterized by the absence of ability to feel pain due to the malfunction or lack of functioning nociceptors - the nerve cells that transmit painful stimuli to the brain. It is typically caused by mutations in the SCN9A gene, which encodes a sodium channel necessary for the function of nociceptors.

Individuals with congenital pain insensitivity may not feel any pain from injuries or other sources of harm, and as a result, they are at risk for serious injury or even death due to lack of protective responses to painful stimuli. They may also have an increased risk of developing recurrent infections and self-mutilation behaviors.

It is important to note that while these individuals do not feel pain, they can still experience other sensory inputs such as touch, temperature, and pressure. Congenital pain insensitivity is a complex medical condition that requires careful management and monitoring by healthcare professionals.

Analgesia is defined as the absence or relief of pain in a patient, achieved through various medical means. It is derived from the Greek word "an-" meaning without and "algein" meaning to feel pain. Analgesics are medications that are used to reduce pain without causing loss of consciousness, and they work by blocking the transmission of pain signals to the brain.

Examples of analgesics include over-the-counter medications such as acetaminophen (Tylenol) and nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen (Advil, Motrin) and naproxen (Aleve). Prescription opioid painkillers, such as oxycodone (OxyContin, Percocet) and hydrocodone (Vicodin), are also used for pain relief but carry a higher risk of addiction and abuse.

Analgesia can also be achieved through non-pharmacological means, such as through nerve blocks, spinal cord stimulation, acupuncture, and other complementary therapies. The choice of analgesic therapy depends on the type and severity of pain, as well as the patient's medical history and individual needs.

Low back pain is a common musculoskeletal disorder characterized by discomfort or pain in the lower part of the back, typically between the costal margin (bottom of the ribcage) and the gluteal folds (buttocks). It can be caused by several factors including strain or sprain of the muscles or ligaments, disc herniation, spinal stenosis, osteoarthritis, or other degenerative conditions affecting the spine. The pain can range from a dull ache to a sharp stabbing sensation and may be accompanied by stiffness, limited mobility, and radiating pain down the legs in some cases. Low back pain is often described as acute (lasting less than 6 weeks), subacute (lasting between 6-12 weeks), or chronic (lasting more than 12 weeks).

Hyperalgesia is a medical term that describes an increased sensitivity to pain. It occurs when the nervous system, specifically the nociceptors (pain receptors), become excessively sensitive to stimuli. This means that a person experiences pain from a stimulus that normally wouldn't cause pain or experiences pain that is more intense than usual. Hyperalgesia can be a result of various conditions such as nerve damage, inflammation, or certain medications. It's an important symptom to monitor in patients with chronic pain conditions, as it may indicate the development of tolerance or addiction to pain medication.

Analgesics are a class of drugs that are used to relieve pain. They work by blocking the transmission of pain signals in the nervous system, allowing individuals to manage their pain levels more effectively. There are many different types of analgesics available, including both prescription and over-the-counter options. Some common examples include acetaminophen (Tylenol), ibuprofen (Advil or Motrin), and opioids such as morphine or oxycodone.

The choice of analgesic will depend on several factors, including the type and severity of pain being experienced, any underlying medical conditions, potential drug interactions, and individual patient preferences. It is important to use these medications as directed by a healthcare provider, as misuse or overuse can lead to serious side effects and potential addiction.

In addition to their pain-relieving properties, some analgesics may also have additional benefits such as reducing inflammation (like in the case of nonsteroidal anti-inflammatory drugs or NSAIDs) or causing sedation (as with certain opioids). However, it is essential to weigh these potential benefits against the risks and side effects associated with each medication.

When used appropriately, analgesics can significantly improve a person's quality of life by helping them manage their pain effectively and allowing them to engage in daily activities more comfortably.

Visual perception refers to the ability to interpret and organize information that comes from our eyes to recognize and understand what we are seeing. It involves several cognitive processes such as pattern recognition, size estimation, movement detection, and depth perception. Visual perception allows us to identify objects, navigate through space, and interact with our environment. Deficits in visual perception can lead to learning difficulties and disabilities.

Physical stimulation, in a medical context, refers to the application of external forces or agents to the body or its tissues to elicit a response. This can include various forms of touch, pressure, temperature, vibration, or electrical currents. The purpose of physical stimulation may be therapeutic, as in the case of massage or physical therapy, or diagnostic, as in the use of reflex tests. It is also used in research settings to study physiological responses and mechanisms.

In a broader sense, physical stimulation can also refer to the body's exposure to physical activity or exercise, which can have numerous health benefits, including improving cardiovascular function, increasing muscle strength and flexibility, and reducing the risk of chronic diseases.

Sensory thresholds are the minimum levels of stimulation that are required to produce a sensation in an individual, as determined through psychophysical testing. These tests measure the point at which a person can just barely detect the presence of a stimulus, such as a sound, light, touch, or smell.

There are two types of sensory thresholds: absolute and difference. Absolute threshold is the minimum level of intensity required to detect a stimulus 50% of the time. Difference threshold, also known as just noticeable difference (JND), is the smallest change in intensity that can be detected between two stimuli.

Sensory thresholds can vary between individuals and are influenced by factors such as age, attention, motivation, and expectations. They are often used in clinical settings to assess sensory function and diagnose conditions such as hearing or vision loss.

Back pain is a common symptom characterized by discomfort or soreness in the back, often occurring in the lower region of the back (lumbago). It can range from a mild ache to a sharp stabbing or shooting pain, and it may be accompanied by stiffness, restricted mobility, and difficulty performing daily activities. Back pain is typically caused by strain or sprain to the muscles, ligaments, or spinal joints, but it can also result from degenerative conditions, disc herniation, spinal stenosis, osteoarthritis, or other medical issues affecting the spine. The severity and duration of back pain can vary widely, with some cases resolving on their own within a few days or weeks, while others may require medical treatment and rehabilitation.

In a medical context, "hot temperature" is not a standard medical term with a specific definition. However, it is often used in relation to fever, which is a common symptom of illness. A fever is typically defined as a body temperature that is higher than normal, usually above 38°C (100.4°F) for adults and above 37.5-38°C (99.5-101.3°F) for children, depending on the source.

Therefore, when a medical professional talks about "hot temperature," they may be referring to a body temperature that is higher than normal due to fever or other causes. It's important to note that a high environmental temperature can also contribute to an elevated body temperature, so it's essential to consider both the body temperature and the environmental temperature when assessing a patient's condition.

Motion perception is the ability to interpret and understand the movement of objects in our environment. It is a complex process that involves multiple areas of the brain and the visual system. In medical terms, motion perception refers to the specific function of the visual system to detect and analyze the movement of visual stimuli. This allows us to perceive and respond to moving objects in our environment, which is crucial for activities such as driving, sports, and even maintaining balance. Disorders in motion perception can lead to conditions like motion sickness or difficulty with depth perception.

Somatosensory evoked potentials (SEPs) are electrical signals generated in the brain and spinal cord in response to the stimulation of peripheral nerves. These responses are recorded and measured to assess the functioning of the somatosensory system, which is responsible for processing sensations such as touch, temperature, vibration, and proprioception (the sense of the position and movement of body parts).

SEPs are typically elicited by applying electrical stimuli to peripheral nerves in the arms or legs. The resulting neural responses are then recorded using electrodes placed on the scalp or other locations on the body. These recordings can provide valuable information about the integrity and function of the nervous system, and are often used in clinical settings to diagnose and monitor conditions such as nerve damage, spinal cord injury, multiple sclerosis, and other neurological disorders.

SEPs can be further categorized based on the specific type of stimulus used and the location of the recording electrodes. For example, short-latency SEPs (SLSEPs) are those that occur within the first 50 milliseconds after stimulation, and are typically recorded from the scalp over the primary sensory cortex. These responses reflect the earliest stages of sensory processing and can be used to assess the integrity of the peripheral nerves and the ascending sensory pathways in the spinal cord.

In contrast, long-latency SEPs (LLSEPs) occur after 50 milliseconds and are typically recorded from more posterior regions of the scalp over the parietal cortex. These responses reflect later stages of sensory processing and can be used to assess higher-level cognitive functions such as attention, memory, and perception.

Overall, SEPs provide a valuable tool for clinicians and researchers seeking to understand the functioning of the somatosensory system and diagnose or monitor neurological disorders.

Social perception, in the context of psychology and social sciences, refers to the ability to interpret and understand other people's behavior, emotions, and intentions. It is the process by which we make sense of the social world around us, by observing and interpreting cues such as facial expressions, body language, tone of voice, and situational context.

In medical terminology, social perception is not a specific diagnosis or condition, but rather a cognitive skill that can be affected in various mental and neurological disorders, such as autism spectrum disorder, schizophrenia, and dementia. For example, individuals with autism may have difficulty interpreting social cues and understanding other people's emotions and intentions, while those with schizophrenia may have distorted perceptions of social situations and interactions.

Healthcare professionals who work with patients with cognitive or neurological disorders may assess their social perception skills as part of a comprehensive evaluation, in order to develop appropriate interventions and support strategies.

Speech perception is the process by which the brain interprets and understands spoken language. It involves recognizing and discriminating speech sounds (phonemes), organizing them into words, and attaching meaning to those words in order to comprehend spoken language. This process requires the integration of auditory information with prior knowledge and context. Factors such as hearing ability, cognitive function, and language experience can all impact speech perception.

Lidocaine is a type of local anesthetic that numbs painful areas and is used to prevent pain during certain medical procedures. It works by blocking the nerves that transmit pain signals to the brain. In addition to its use as an anesthetic, lidocaine can also be used to treat irregular heart rates and relieve itching caused by allergic reactions or skin conditions such as eczema.

Lidocaine is available in various forms, including creams, gels, ointments, sprays, solutions, and injectable preparations. It can be applied directly to the skin or mucous membranes, or it can be administered by injection into a muscle or vein. The specific dosage and method of administration will depend on the reason for its use and the individual patient's medical history and current health status.

Like all medications, lidocaine can have side effects, including allergic reactions, numbness that lasts too long, and in rare cases, heart problems or seizures. It is important to follow the instructions of a healthcare provider carefully when using lidocaine to minimize the risk of adverse effects.

Neuralgia is a type of pain that occurs along the pathway of a nerve, often caused by damage or irritation to the nerve. It is typically described as a sharp, stabbing, burning, or electric-shock like pain that can be severe and debilitating. Neuralgia can affect any nerve in the body, but it most commonly occurs in the facial area (trigeminal neuralgia) or in the nerves related to the spine (postherpetic neuralgia). The pain associated with neuralgia can be intermittent or constant and may be worsened by certain triggers such as touch, temperature changes, or movement. Treatment for neuralgia typically involves medications to manage pain, as well as other therapies such as nerve blocks, surgery, or lifestyle modifications.

Abdominal pain is defined as discomfort or painful sensation in the abdomen. The abdomen is the region of the body between the chest and the pelvis, and contains many important organs such as the stomach, small intestine, large intestine, liver, gallbladder, pancreas, and spleen. Abdominal pain can vary in intensity from mild to severe, and can be acute or chronic depending on the underlying cause.

Abdominal pain can have many different causes, ranging from benign conditions such as gastritis, indigestion, or constipation, to more serious conditions such as appendicitis, inflammatory bowel disease, or abdominal aortic aneurysm. The location, quality, and duration of the pain can provide important clues about its cause. For example, sharp, localized pain in the lower right quadrant of the abdomen may indicate appendicitis, while crampy, diffuse pain in the lower abdomen may suggest irritable bowel syndrome.

It is important to seek medical attention if you experience severe or persistent abdominal pain, especially if it is accompanied by other symptoms such as fever, vomiting, or bloody stools. A thorough physical examination, including a careful history and a focused abdominal exam, can help diagnose the underlying cause of the pain and guide appropriate treatment.

The placebo effect is a psychological or psychophysiological phenomenon in which a person's symptoms improve following a treatment but this improvement is not attributable to the properties of the treatment itself. Instead, it is believed to be due to the mind's belief in the effectiveness of the treatment, often influenced by positive expectations and the ritualistic aspects of the therapy itself.

Placebos are often used in clinical trials as a control group to compare against the actual treatment. The placebo effect can make it challenging to determine whether an observed improvement is truly due to the treatment or other factors.

Neck pain is discomfort or soreness in the neck region, which can extend from the base of the skull to the upper part of the shoulder blades, caused by injury, irritation, or inflammation of the muscles, ligaments, or nerves in the cervical spine. The pain may worsen with movement and can be accompanied by stiffness, numbness, tingling, or weakness in the neck, arms, or hands. In some cases, headaches can also occur as a result of neck pain.

In medicine, "intractable pain" is a term used to describe pain that is difficult to manage, control or relieve with standard treatments. It's a type of chronic pain that continues for an extended period, often months or even years, and does not respond to conventional therapies such as medications, physical therapy, or surgery. Intractable pain can significantly affect a person's quality of life, causing emotional distress, sleep disturbances, and reduced mobility. It is essential to distinguish intractable pain from acute pain, which is typically sharp and short-lived, resulting from tissue damage or inflammation.

Intractable pain may be classified as:

1. Refractory pain: Pain that persists despite optimal treatment with various modalities, including medications, interventions, and multidisciplinary care.
2. Incurable pain: Pain caused by a progressive or incurable disease, such as cancer, for which no curative treatment is available.
3. Functional pain: Pain without an identifiable organic cause that does not respond to standard treatments.

Managing intractable pain often requires a multidisciplinary approach involving healthcare professionals from various fields, including pain specialists, neurologists, psychiatrists, psychologists, and physical therapists. Treatment options may include:

1. Adjuvant medications: Medications that are not primarily analgesics but have been found to help with pain relief, such as antidepressants, anticonvulsants, and muscle relaxants.
2. Interventional procedures: Minimally invasive techniques like nerve blocks, spinal cord stimulation, or intrathecal drug delivery systems that target specific nerves or areas of the body to reduce pain signals.
3. Psychological interventions: Techniques such as cognitive-behavioral therapy (CBT), mindfulness meditation, and relaxation training can help patients cope with chronic pain and improve their overall well-being.
4. Physical therapy and rehabilitation: Exercise programs, massage, acupuncture, and other physical therapies may provide relief for some types of intractable pain.
5. Complementary and alternative medicine (CAM): Techniques like yoga, tai chi, hypnosis, or biofeedback can be helpful in managing chronic pain.
6. Lifestyle modifications: Dietary changes, stress management, and quitting smoking may also contribute to improved pain management.

I'm sorry for any confusion, but "Sensory System Agents" is not a widely recognized or established medical term. Sensory systems refer to the parts of the nervous system that process and transmit information about the world around us, including the senses of sight, hearing, touch, taste, and smell. However, there are no specific "agents" that are generally recognized as being solely dedicated to affecting these systems in a medical context.

If you're referring to specific pharmaceutical agents or drugs that affect sensory systems, these would be more accurately described using terms related to the specific system (like "ophthalmic agents" for vision, or "anesthetics" for touch/pain) and the specific drug class or mechanism of action.

If you have a more specific context in mind, I'd be happy to try to provide a more targeted answer!

Beta-endorphins are naturally occurring opioid peptides that are produced in the brain and other parts of the body. They are synthesized from a larger precursor protein called proopiomelanocortin (POMC) and consist of 31 amino acids. Beta-endorphins have potent analgesic effects, which means they can reduce the perception of pain. They also play a role in regulating mood, emotions, and various physiological processes such as immune function and hormonal regulation.

Beta-endorphins bind to opioid receptors in the brain and other tissues, leading to a range of effects including pain relief, sedation, euphoria, and reduced anxiety. They are released in response to stress, physical activity, and certain physiological conditions such as pregnancy and lactation. Beta-endorphins have been studied for their potential therapeutic uses in the treatment of pain, addiction, and mood disorders. However, more research is needed to fully understand their mechanisms of action and potential side effects.

Analgesics, opioid are a class of drugs used for the treatment of pain. They work by binding to specific receptors in the brain and spinal cord, blocking the transmission of pain signals to the brain. Opioids can be synthetic or natural, and include drugs such as morphine, codeine, oxycodone, hydrocodone, hydromorphone, fentanyl, and methadone. They are often used for moderate to severe pain, such as that resulting from injury, surgery, or chronic conditions like cancer. However, opioids can also produce euphoria, physical dependence, and addiction, so they are tightly regulated and carry a risk of misuse.

In medical terms, sensation refers to the ability to perceive and interpret various stimuli from our environment through specialized receptor cells located throughout the body. These receptors convert physical stimuli such as light, sound, temperature, pressure, and chemicals into electrical signals that are transmitted to the brain via nerves. The brain then interprets these signals, allowing us to experience sensations like sight, hearing, touch, taste, and smell.

There are two main types of sensations: exteroceptive and interoceptive. Exteroceptive sensations involve stimuli from outside the body, such as light, sound, and touch. Interoceptive sensations, on the other hand, refer to the perception of internal bodily sensations, such as hunger, thirst, heartbeat, or emotions.

Disorders in sensation can result from damage to the nervous system, including peripheral nerves, spinal cord, or brain. Examples include numbness, tingling, pain, or loss of sensation in specific body parts, which can significantly impact a person's quality of life and ability to perform daily activities.

Pelvic pain is defined as discomfort or unpleasant sensation in the lower abdominal region, below the belly button, and between the hips. It can be acute (sudden and lasting for a short time) or chronic (persisting for months or even years), and it may be steady or intermittent, mild or severe. The pain can have various causes, including musculoskeletal issues, nerve irritation, infection, inflammation, or organic diseases in the reproductive, urinary, or gastrointestinal systems. Accurate diagnosis often requires a thorough medical evaluation to determine the underlying cause and develop an appropriate treatment plan.

The somatosensory cortex is a part of the brain located in the postcentral gyrus of the parietal lobe, which is responsible for processing sensory information from the body. It receives and integrates tactile, proprioceptive, and thermoception inputs from the skin, muscles, joints, and internal organs, allowing us to perceive and interpret touch, pressure, pain, temperature, vibration, position, and movement of our body parts. The somatosensory cortex is organized in a map-like manner, known as the sensory homunculus, where each body part is represented according to its relative sensitivity and density of innervation. This organization allows for precise localization and discrimination of tactile stimuli across the body surface.

Depth perception is the ability to accurately judge the distance or separation of an object in three-dimensional space. It is a complex visual process that allows us to perceive the world in three dimensions and to understand the spatial relationships between objects.

Depth perception is achieved through a combination of monocular cues, which are visual cues that can be perceived with one eye, and binocular cues, which require input from both eyes. Monocular cues include perspective (the relative size of objects), texture gradients (finer details become smaller as distance increases), and atmospheric perspective (colors become less saturated and lighter in value as distance increases). Binocular cues include convergence (the degree to which the eyes must turn inward to focus on an object) and retinal disparity (the slight difference in the images projected onto the two retinas due to the slightly different positions of the eyes).

Deficits in depth perception can occur due to a variety of factors, including eye disorders, brain injuries, or developmental delays. These deficits can result in difficulties with tasks such as driving, sports, or navigating complex environments. Treatment for depth perception deficits may include vision therapy, corrective lenses, or surgery.

A questionnaire in the medical context is a standardized, systematic, and structured tool used to gather information from individuals regarding their symptoms, medical history, lifestyle, or other health-related factors. It typically consists of a series of written questions that can be either self-administered or administered by an interviewer. Questionnaires are widely used in various areas of healthcare, including clinical research, epidemiological studies, patient care, and health services evaluation to collect data that can inform diagnosis, treatment planning, and population health management. They provide a consistent and organized method for obtaining information from large groups or individual patients, helping to ensure accurate and comprehensive data collection while minimizing bias and variability in the information gathered.

Acupuncture analgesia is a form of pain relief that involves the stimulation of specific points on the body, called acupoints, using thin needles. This technique is based on traditional Chinese medicine (TCM) principles, which suggest that energy, or "qi," flows through the body along pathways called meridians. According to TCM, blockages or imbalances in this flow of qi can lead to illness or pain. By inserting needles at specific acupoints, acupuncture is thought to help restore the balance and flow of qi, thereby alleviating pain and promoting healing.

In modern medical terms, acupuncture analgesia is believed to work by stimulating the nervous system and triggering the release of natural painkillers called endorphins. The needles may also cause localized changes in blood flow and inflammation, which can help reduce pain and promote healing in the affected area.

Acupuncture has been shown to be effective for a variety of pain conditions, including osteoarthritis, migraines, and chronic low back pain. However, it is important to note that acupuncture should be performed by a qualified practitioner and may not be suitable for everyone. As with any medical treatment, there are potential risks and side effects associated with acupuncture, including infection, bruising, and bleeding. It is always best to consult with a healthcare provider before starting any new treatment.

Local anesthetics are a type of medication that is used to block the sensation of pain in a specific area of the body. They work by temporarily numbing the nerves in that area, preventing them from transmitting pain signals to the brain. Local anesthetics can be administered through various routes, including topical application (such as creams or gels), injection (such as into the skin or tissues), or regional nerve blocks (such as epidural or spinal anesthesia).

Some common examples of local anesthetics include lidocaine, prilocaine, bupivacaine, and ropivacaine. These medications can be used for a variety of medical procedures, ranging from minor surgeries (such as dental work or skin biopsies) to more major surgeries (such as joint replacements or hernia repairs).

Local anesthetics are generally considered safe when used appropriately, but they can have side effects and potential complications. These may include allergic reactions, toxicity (if too much is administered), and nerve damage (if the medication is injected into a nerve). It's important to follow your healthcare provider's instructions carefully when using local anesthetics, and to report any unusual symptoms or side effects promptly.

Unmyelinated nerve fibers, also known as unmyelinated axons or non-myelinated fibers, are nerve cells that lack a myelin sheath. Myelin is a fatty, insulating substance that surrounds the axon of many nerve cells and helps to increase the speed of electrical impulses traveling along the nerve fiber.

In unmyelinated nerve fibers, the axons are surrounded by a thin layer of Schwann cell processes called the endoneurium, but there is no continuous myelin sheath. Instead, the axons are packed closely together in bundles, with several axons lying within the same Schwann cell.

Unmyelinated nerve fibers tend to be smaller in diameter than myelinated fibers and conduct electrical impulses more slowly. They are commonly found in the autonomic nervous system, which controls involuntary functions such as heart rate, blood pressure, and digestion, as well as in sensory nerves that transmit pain and temperature signals.

Microvascular angina, also known as cardiac syndrome X or microvascular ischemia, is a type of angina (chest pain) that results from reduced blood flow to the heart muscle due to dysfunction in the small coronary arteries (microvasculature). These vessels are too small to be visualized during conventional diagnostic tests like coronary angiography.

The medical definition of microvascular angina is:

A clinical syndrome characterized by the presence of anginal chest pain, often accompanied by evidence of myocardial ischemia (insufficient blood flow to the heart muscle), in the absence of obstructive coronary artery disease on conventional diagnostic imaging. The underlying mechanism involves dysfunction and impaired regulation of the microvasculature, leading to reduced vasodilatory capacity, increased vasoconstriction, and ultimately, inadequate oxygen supply to meet the metabolic demands of the heart muscle.

Microvascular angina is more prevalent in women, especially those with risk factors such as hypertension, diabetes, hyperlipidemia, and smoking. Diagnosis often requires specialized testing like coronary flow reserve assessment using positron emission tomography (PET) or cardiac magnetic resonance imaging (MRI). Treatment typically involves a combination of lifestyle modifications, medications to improve blood vessel function and reduce chest pain, and sometimes, invasive treatments such as transmyocardial laser revascularization.

Acute pain is a type of pain that comes on suddenly and can be severe, but it typically lasts for a short period of time. It is often described as sharp or stabbing and can be caused by tissue damage, inflammation, or injury. Acute pain is the body's way of signaling that something is wrong and that action needs to be taken to address the underlying cause.

Acute pain is different from chronic pain, which is pain that persists for 12 weeks or longer. Chronic pain can be caused by a variety of factors, including ongoing medical conditions, nerve damage, or inflammation. It is important to seek medical attention if you are experiencing acute pain that does not improve or becomes severe, as it may be a sign of a more serious underlying condition.

Auditory perception refers to the process by which the brain interprets and makes sense of the sounds we hear. It involves the recognition and interpretation of different frequencies, intensities, and patterns of sound waves that reach our ears through the process of hearing. This allows us to identify and distinguish various sounds such as speech, music, and environmental noises.

The auditory system includes the outer ear, middle ear, inner ear, and the auditory nerve, which transmits electrical signals to the brain's auditory cortex for processing and interpretation. Auditory perception is a complex process that involves multiple areas of the brain working together to identify and make sense of sounds in our environment.

Disorders or impairments in auditory perception can result in difficulties with hearing, understanding speech, and identifying environmental sounds, which can significantly impact communication, learning, and daily functioning.

Catechol-O-methyltransferase (COMT) is an enzyme that plays a role in the metabolism of catecholamines, which are neurotransmitters and hormones such as dopamine, norepinephrine, and epinephrine. COMT mediates the transfer of a methyl group from S-adenosylmethionine (SAM) to a catechol functional group in these molecules, resulting in the formation of methylated products that are subsequently excreted.

The methylation of catecholamines by COMT regulates their concentration and activity in the body, and genetic variations in the COMT gene can affect enzyme function and contribute to individual differences in the metabolism of these neurotransmitters. This has been implicated in various neurological and psychiatric conditions, including Parkinson's disease, schizophrenia, and attention deficit hyperactivity disorder (ADHD).

Afferent pathways, also known as sensory pathways, refer to the neural connections that transmit sensory information from the peripheral nervous system to the central nervous system (CNS), specifically to the brain and spinal cord. These pathways are responsible for carrying various types of sensory information, such as touch, temperature, pain, pressure, vibration, hearing, vision, and taste, to the CNS for processing and interpretation.

The afferent pathways begin with sensory receptors located throughout the body, which detect changes in the environment and convert them into electrical signals. These signals are then transmitted via afferent neurons, also known as sensory neurons, to the spinal cord or brainstem. Within the CNS, the information is further processed and integrated with other neural inputs before being relayed to higher cognitive centers for conscious awareness and response.

Understanding the anatomy and physiology of afferent pathways is essential for diagnosing and treating various neurological conditions that affect sensory function, such as neuropathies, spinal cord injuries, and brain disorders.

"Cold temperature" is a relative term and its definition can vary depending on the context. In general, it refers to temperatures that are lower than those normally experienced or preferred by humans and other warm-blooded animals. In a medical context, cold temperature is often defined as an environmental temperature that is below 16°C (60.8°F).

Exposure to cold temperatures can have various physiological effects on the human body, such as vasoconstriction of blood vessels near the skin surface, increased heart rate and metabolic rate, and shivering, which helps to generate heat and maintain body temperature. Prolonged exposure to extreme cold temperatures can lead to hypothermia, a potentially life-threatening condition characterized by a drop in core body temperature below 35°C (95°F).

It's worth noting that some people may have different sensitivities to cold temperatures due to factors such as age, health status, and certain medical conditions. For example, older adults, young children, and individuals with circulatory or neurological disorders may be more susceptible to the effects of cold temperatures.

Fibromyalgia is a chronic disorder characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and cognitive difficulties. The pain typically occurs in specific tender points or trigger points, which are located on the neck, shoulders, back, hips, arms, and legs. These points are painful when pressure is applied.

The exact cause of fibromyalgia is unknown, but it appears to be related to abnormalities in the way the brain processes pain signals. It may also be associated with certain genetic factors, physical trauma, infection, or emotional stress. Fibromyalgia is more common in women than men and tends to develop between the ages of 20 and 50.

Fibromyalgia can be difficult to diagnose because its symptoms are similar to those of other conditions, such as rheumatoid arthritis, lupus, and chronic fatigue syndrome. However, a diagnosis of fibromyalgia may be made if a person has widespread pain for at least three months and tenderness in at least 11 of 18 specific points on the body when pressure is applied.

There is no cure for fibromyalgia, but medications, therapy, and lifestyle changes can help manage its symptoms. Treatment may include pain relievers, antidepressants, anti-seizure drugs, physical therapy, counseling, stress reduction techniques, and regular exercise.

Medical Definition:

Magnetic Resonance Imaging (MRI) is a non-invasive diagnostic imaging technique that uses a strong magnetic field and radio waves to create detailed cross-sectional or three-dimensional images of the internal structures of the body. The patient lies within a large, cylindrical magnet, and the scanner detects changes in the direction of the magnetic field caused by protons in the body. These changes are then converted into detailed images that help medical professionals to diagnose and monitor various medical conditions, such as tumors, injuries, or diseases affecting the brain, spinal cord, heart, blood vessels, joints, and other internal organs. MRI does not use radiation like computed tomography (CT) scans.

Referred pain is a type of pain that is felt in a part of the body other than its actual source. This occurs because the brain incorrectly interprets nerve signals from damaged tissues or organs. In the case of referred pain, the brain misinterprets the location of the pain signal and attributes it to a different area of the body.

Referred pain is often described as a dull, aching sensation rather than a sharp, stabbing pain. It can be difficult to diagnose because the source of the pain may not be immediately apparent. Common examples of referred pain include:

* Heart attack pain that is felt in the left arm or jaw
* Gallbladder pain that is felt in the right shoulder blade
* Kidney stones that cause pain in the lower back and abdomen
* Appendicitis that causes pain in the lower right quadrant of the abdomen, but can sometimes be referred to the lower left quadrant in pregnant women or those with a longer colon.

Referred pain is thought to occur because the nerves carrying pain signals from different parts of the body converge on the same neurons in the spinal cord before traveling to the brain. If these neurons are stimulated by pain signals from multiple sources, the brain may have difficulty distinguishing between them and may interpret the pain as coming from a single location.

Form perception, also known as shape perception, is not a term that has a specific medical definition. However, in the field of neuropsychology and sensory perception, form perception refers to the ability to recognize and interpret different shapes and forms of objects through visual processing. This ability is largely dependent on the integrity of the visual cortex and its ability to process and interpret information received from the retina.

Damage to certain areas of the brain, particularly in the occipital and parietal lobes, can result in deficits in form perception, leading to difficulties in recognizing and identifying objects based on their shape or form. This condition is known as visual agnosia and can be a symptom of various neurological disorders such as stroke, brain injury, or degenerative diseases like Alzheimer's disease.

A laser is not a medical term per se, but a physical concept that has important applications in medicine. The term "LASER" stands for "Light Amplification by Stimulated Emission of Radiation." It refers to a device that produces and amplifies light with specific characteristics, such as monochromaticity (single wavelength), coherence (all waves moving in the same direction), and high intensity.

In medicine, lasers are used for various therapeutic and diagnostic purposes, including surgery, dermatology, ophthalmology, and dentistry. They can be used to cut, coagulate, or vaporize tissues with great precision, minimizing damage to surrounding structures. Additionally, lasers can be used to detect and measure physiological parameters, such as blood flow and oxygen saturation.

It's important to note that while lasers are powerful tools in medicine, they must be used by trained professionals to ensure safe and effective treatment.

The brain is the central organ of the nervous system, responsible for receiving and processing sensory information, regulating vital functions, and controlling behavior, movement, and cognition. It is divided into several distinct regions, each with specific functions:

1. Cerebrum: The largest part of the brain, responsible for higher cognitive functions such as thinking, learning, memory, language, and perception. It is divided into two hemispheres, each controlling the opposite side of the body.
2. Cerebellum: Located at the back of the brain, it is responsible for coordinating muscle movements, maintaining balance, and fine-tuning motor skills.
3. Brainstem: Connects the cerebrum and cerebellum to the spinal cord, controlling vital functions such as breathing, heart rate, and blood pressure. It also serves as a relay center for sensory information and motor commands between the brain and the rest of the body.
4. Diencephalon: A region that includes the thalamus (a major sensory relay station) and hypothalamus (regulates hormones, temperature, hunger, thirst, and sleep).
5. Limbic system: A group of structures involved in emotional processing, memory formation, and motivation, including the hippocampus, amygdala, and cingulate gyrus.

The brain is composed of billions of interconnected neurons that communicate through electrical and chemical signals. It is protected by the skull and surrounded by three layers of membranes called meninges, as well as cerebrospinal fluid that provides cushioning and nutrients.

Formaldehyde is a colorless, pungent, and volatile chemical compound with the formula CH2O. It is a naturally occurring substance that is found in certain fruits like apples and vegetables, as well as in animals. However, the majority of formaldehyde used in industry is synthetically produced.

In the medical field, formaldehyde is commonly used as a preservative for biological specimens such as organs, tissues, and cells. It works by killing bacteria and inhibiting the decaying process. Formaldehyde is also used in the production of various industrial products, including adhesives, resins, textiles, and paper products.

However, formaldehyde can be harmful to human health if inhaled or ingested in large quantities. It can cause irritation to the eyes, nose, throat, and skin, and prolonged exposure has been linked to respiratory problems and cancer. Therefore, it is essential to handle formaldehyde with care and use appropriate safety measures when working with this chemical compound.

A chronic disease is a long-term medical condition that often progresses slowly over a period of years and requires ongoing management and care. These diseases are typically not fully curable, but symptoms can be managed to improve quality of life. Common chronic diseases include heart disease, stroke, cancer, diabetes, arthritis, and COPD (chronic obstructive pulmonary disease). They are often associated with advanced age, although they can also affect children and younger adults. Chronic diseases can have significant impacts on individuals' physical, emotional, and social well-being, as well as on healthcare systems and society at large.

In the field of medicine, "time factors" refer to the duration of symptoms or time elapsed since the onset of a medical condition, which can have significant implications for diagnosis and treatment. Understanding time factors is crucial in determining the progression of a disease, evaluating the effectiveness of treatments, and making critical decisions regarding patient care.

For example, in stroke management, "time is brain," meaning that rapid intervention within a specific time frame (usually within 4.5 hours) is essential to administering tissue plasminogen activator (tPA), a clot-busting drug that can minimize brain damage and improve patient outcomes. Similarly, in trauma care, the "golden hour" concept emphasizes the importance of providing definitive care within the first 60 minutes after injury to increase survival rates and reduce morbidity.

Time factors also play a role in monitoring the progression of chronic conditions like diabetes or heart disease, where regular follow-ups and assessments help determine appropriate treatment adjustments and prevent complications. In infectious diseases, time factors are crucial for initiating antibiotic therapy and identifying potential outbreaks to control their spread.

Overall, "time factors" encompass the significance of recognizing and acting promptly in various medical scenarios to optimize patient outcomes and provide effective care.

Emotions are complex psychological states that involve three distinct components: a subjective experience, a physiological response, and a behavioral or expressive response. Emotions can be short-lived, such as a flash of anger, or more long-lasting, such as enduring sadness. They can also vary in intensity, from mild irritation to intense joy or fear.

Emotions are often distinguished from other psychological states, such as moods and temperament, which may be less specific and more enduring. Emotions are typically thought to have a clear cause or object, such as feeling happy when you receive good news or feeling anxious before a job interview.

There are many different emotions that people can experience, including happiness, sadness, anger, fear, surprise, disgust, and shame. These emotions are often thought to serve important adaptive functions, helping individuals respond to challenges and opportunities in their environment.

In medical contexts, emotions may be relevant to the diagnosis and treatment of various mental health conditions, such as depression, anxiety disorders, and bipolar disorder. Abnormalities in emotional processing and regulation have been implicated in many psychiatric illnesses, and therapies that target these processes may be effective in treating these conditions.

Capsaicin is defined in medical terms as the active component of chili peppers (genus Capsicum) that produces a burning sensation when it comes into contact with mucous membranes or skin. It is a potent irritant and is used topically as a counterirritant in some creams and patches to relieve pain. Capsaicin works by depleting substance P, a neurotransmitter that relays pain signals to the brain, from nerve endings.

Here is the medical definition of capsaicin from the Merriam-Webster's Medical Dictionary:

caпсаісіn : an alkaloid (C18H27NO3) that is the active principle of red peppers and is used in topical preparations as a counterirritant and analgesic.

Analysis of Variance (ANOVA) is a statistical technique used to compare the means of two or more groups and determine whether there are any significant differences between them. It is a way to analyze the variance in a dataset to determine whether the variability between groups is greater than the variability within groups, which can indicate that the groups are significantly different from one another.

ANOVA is based on the concept of partitioning the total variance in a dataset into two components: variance due to differences between group means (also known as "between-group variance") and variance due to differences within each group (also known as "within-group variance"). By comparing these two sources of variance, ANOVA can help researchers determine whether any observed differences between groups are statistically significant, or whether they could have occurred by chance.

ANOVA is a widely used technique in many areas of research, including biology, psychology, engineering, and business. It is often used to compare the means of two or more experimental groups, such as a treatment group and a control group, to determine whether the treatment had a significant effect. ANOVA can also be used to compare the means of different populations or subgroups within a population, to identify any differences that may exist between them.

Shoulder pain is a condition characterized by discomfort or hurt in the shoulder joint, muscles, tendons, ligaments, or surrounding structures. The shoulder is one of the most mobile joints in the body, and this mobility makes it prone to injury and pain. Shoulder pain can result from various causes, including overuse, trauma, degenerative conditions, or referred pain from other areas of the body.

The shoulder joint is a ball-and-socket joint made up of three bones: the humerus (upper arm bone), scapula (shoulder blade), and clavicle (collarbone). The rotator cuff, a group of four muscles that surround and stabilize the shoulder joint, can also be a source of pain if it becomes inflamed or torn.

Shoulder pain can range from mild to severe, and it may be accompanied by stiffness, swelling, bruising, weakness, numbness, tingling, or reduced mobility in the affected arm. The pain may worsen with movement, lifting objects, or performing certain activities, such as reaching overhead or behind the back.

Medical evaluation is necessary to determine the underlying cause of shoulder pain and develop an appropriate treatment plan. Treatment options may include rest, physical therapy, medication, injections, or surgery, depending on the severity and nature of the condition.

In medical terms, pressure is defined as the force applied per unit area on an object or body surface. It is often measured in millimeters of mercury (mmHg) in clinical settings. For example, blood pressure is the force exerted by circulating blood on the walls of the arteries and is recorded as two numbers: systolic pressure (when the heart beats and pushes blood out) and diastolic pressure (when the heart rests between beats).

Pressure can also refer to the pressure exerted on a wound or incision to help control bleeding, or the pressure inside the skull or spinal canal. High or low pressure in different body systems can indicate various medical conditions and require appropriate treatment.

Time perception, in the context of medicine and neuroscience, refers to the subjective experience and cognitive representation of time intervals. It is a complex process that involves the integration of various sensory, attentional, and emotional factors.

Disorders or injuries to certain brain regions, such as the basal ganglia, thalamus, or cerebellum, can affect time perception, leading to symptoms such as time distortion, where time may seem to pass more slowly or quickly than usual. Additionally, some neurological and psychiatric conditions, such as Parkinson's disease, attention deficit hyperactivity disorder (ADHD), and depression, have been associated with altered time perception.

Assessment of time perception is often used in neuropsychological evaluations to help diagnose and monitor the progression of certain neurological disorders. Various tests exist to measure time perception, such as the temporal order judgment task, where individuals are asked to judge which of two stimuli occurred first, or the duration estimation task, where individuals are asked to estimate the duration of a given stimulus.

Musculoskeletal pain is discomfort or pain that affects the muscles, bones, ligaments, tendons, and nerves. It can be caused by injury, overuse, or disease and can affect any part of the body, including the neck, back, shoulders, hips, and extremities. The pain can range from mild to severe and may be accompanied by stiffness, swelling, and decreased range of motion. Common causes of musculoskeletal pain include arthritis, fibromyalgia, tendinitis, bursitis, and muscle or ligament strain. Treatment for musculoskeletal pain depends on the underlying cause and may include physical therapy, medication, and in some cases, surgery.

In medical and psychological terms, "affect" refers to a person's emotional or expressive state, mood, or dispositions that are outwardly manifested in their behavior, facial expressions, demeanor, or speech. Affect can be described as being congruent or incongruent with an individual's thoughts and experiences.

There are different types of affect, including:

1. Neutral affect: When a person shows no apparent emotion or displays minimal emotional expressiveness.
2. Positive affect: When a person exhibits positive emotions such as happiness, excitement, or enthusiasm.
3. Negative affect: When a person experiences and displays negative emotions like sadness, anger, or fear.
4. Blunted affect: When a person's emotional response is noticeably reduced or diminished, often observed in individuals with certain mental health conditions, such as schizophrenia.
5. Flat affect: When a person has an almost complete absence of emotional expressiveness, which can be indicative of severe depression or other mental health disorders.
6. Labile affect: When a person's emotional state fluctuates rapidly and frequently between positive and negative emotions, often observed in individuals with certain neurological conditions or mood disorders.

Clinicians may assess a patient's affect during an interview or examination to help diagnose mental health conditions, evaluate treatment progress, or monitor overall well-being.

Morphine is a potent opioid analgesic (pain reliever) derived from the opium poppy. It works by binding to opioid receptors in the brain and spinal cord, blocking the transmission of pain signals and reducing the perception of pain. Morphine is used to treat moderate to severe pain, including pain associated with cancer, myocardial infarction, and other conditions. It can also be used as a sedative and cough suppressant.

Morphine has a high potential for abuse and dependence, and its use should be closely monitored by healthcare professionals. Common side effects of morphine include drowsiness, respiratory depression, constipation, nausea, and vomiting. Overdose can result in respiratory failure, coma, and death.

Reaction time, in the context of medicine and physiology, refers to the time period between the presentation of a stimulus and the subsequent initiation of a response. This complex process involves the central nervous system, particularly the brain, which perceives the stimulus, processes it, and then sends signals to the appropriate muscles or glands to react.

There are different types of reaction times, including simple reaction time (responding to a single, expected stimulus) and choice reaction time (choosing an appropriate response from multiple possibilities). These measures can be used in clinical settings to assess various aspects of neurological function, such as cognitive processing speed, motor control, and alertness.

However, it is important to note that reaction times can be influenced by several factors, including age, fatigue, attention, and the use of certain medications or substances.

Anxiety: A feeling of worry, nervousness, or unease, typically about an imminent event or something with an uncertain outcome. In a medical context, anxiety refers to a mental health disorder characterized by feelings of excessive and persistent worry, fear, or panic that interfere with daily activities. It can also be a symptom of other medical conditions, such as heart disease, diabetes, or substance abuse disorders. Anxiety disorders include generalized anxiety disorder, panic disorder, social anxiety disorder, and phobias.

'Animal behavior' refers to the actions or responses of animals to various stimuli, including their interactions with the environment and other individuals. It is the study of the actions of animals, whether they are instinctual, learned, or a combination of both. Animal behavior includes communication, mating, foraging, predator avoidance, and social organization, among other things. The scientific study of animal behavior is called ethology. This field seeks to understand the evolutionary basis for behaviors as well as their physiological and psychological mechanisms.

The double-blind method is a study design commonly used in research, including clinical trials, to minimize bias and ensure the objectivity of results. In this approach, both the participants and the researchers are unaware of which group the participants are assigned to, whether it be the experimental group or the control group. This means that neither the participants nor the researchers know who is receiving a particular treatment or placebo, thus reducing the potential for bias in the evaluation of outcomes. The assignment of participants to groups is typically done by a third party not involved in the study, and the codes are only revealed after all data have been collected and analyzed.

Spinal ganglia, also known as dorsal root ganglia, are clusters of nerve cell bodies located in the peripheral nervous system. They are situated along the length of the spinal cord and are responsible for transmitting sensory information from the body to the brain. Each spinal ganglion contains numerous neurons, or nerve cells, with long processes called axons that extend into the periphery and innervate various tissues and organs. The cell bodies within the spinal ganglia receive sensory input from these axons and transmit this information to the central nervous system via the dorsal roots of the spinal nerves. This allows the brain to interpret and respond to a wide range of sensory stimuli, including touch, temperature, pain, and proprioception (the sense of the position and movement of one's body).

Pitch perception is the ability to identify and discriminate different frequencies or musical notes. It is the way our auditory system interprets and organizes sounds based on their highness or lowness, which is determined by the frequency of the sound waves. A higher pitch corresponds to a higher frequency, while a lower pitch corresponds to a lower frequency. Pitch perception is an important aspect of hearing and is crucial for understanding speech, enjoying music, and localizing sounds in our environment. It involves complex processing in the inner ear and auditory nervous system.

Taste perception refers to the ability to recognize and interpret different tastes, such as sweet, salty, sour, bitter, and umami, which are detected by specialized sensory cells called taste buds located on the tongue and other areas in the mouth. These taste signals are then transmitted to the brain, where they are processed and identified as specific tastes. Taste perception is an important sense that helps us to appreciate and enjoy food, and it also plays a role in our ability to detect potentially harmful substances in our diet.

Psychophysics is not a medical term per se, but rather a subfield of psychology and neuroscience that studies the relationship between physical stimuli and the sensations and perceptions they produce. It involves the quantitative investigation of psychological functions, such as how brightness or loudness is perceived relative to the physical intensity of light or sound.

In medical contexts, psychophysical methods may be used in research or clinical settings to understand how patients with neurological conditions or sensory impairments perceive and respond to different stimuli. This information can inform diagnostic assessments, treatment planning, and rehabilitation strategies.

Hypnotics and sedatives are classes of medications that have depressant effects on the central nervous system, leading to sedation (calming or inducing sleep), reduction in anxiety, and in some cases, decreased awareness or memory. These agents work by affecting the neurotransmitter GABA (gamma-aminobutyric acid) in the brain, which results in inhibitory effects on neuronal activity.

Hypnotics are primarily used for the treatment of insomnia and other sleep disorders, while sedatives are often prescribed to manage anxiety or to produce a calming effect before medical procedures. Some medications can function as both hypnotics and sedatives, depending on the dosage and specific formulation. Common examples of these medications include benzodiazepines (such as diazepam and lorazepam), non-benzodiazepine hypnotics (such as zolpidem and eszopiclone), barbiturates, and certain antihistamines.

It is essential to use these medications under the guidance of a healthcare professional, as they can have potential side effects, such as drowsiness, dizziness, confusion, and impaired coordination. Additionally, long-term use or high doses may lead to tolerance, dependence, and withdrawal symptoms upon discontinuation.

Space perception, in the context of neuroscience and psychology, refers to the ability to perceive and understand the spatial arrangement of objects and their relationship to oneself. It involves integrating various sensory inputs such as visual, auditory, tactile, and proprioceptive information to create a coherent three-dimensional representation of our environment.

This cognitive process enables us to judge distances, sizes, shapes, and movements of objects around us. It also helps us navigate through space, reach for objects, avoid obstacles, and maintain balance. Disorders in space perception can lead to difficulties in performing everyday activities and may be associated with neurological conditions such as stroke, brain injury, or neurodevelopmental disorders like autism.

Electric stimulation, also known as electrical nerve stimulation or neuromuscular electrical stimulation, is a therapeutic treatment that uses low-voltage electrical currents to stimulate nerves and muscles. It is often used to help manage pain, promote healing, and improve muscle strength and mobility. The electrical impulses can be delivered through electrodes placed on the skin or directly implanted into the body.

In a medical context, electric stimulation may be used for various purposes such as:

1. Pain management: Electric stimulation can help to block pain signals from reaching the brain and promote the release of endorphins, which are natural painkillers produced by the body.
2. Muscle rehabilitation: Electric stimulation can help to strengthen muscles that have become weak due to injury, illness, or surgery. It can also help to prevent muscle atrophy and improve range of motion.
3. Wound healing: Electric stimulation can promote tissue growth and help to speed up the healing process in wounds, ulcers, and other types of injuries.
4. Urinary incontinence: Electric stimulation can be used to strengthen the muscles that control urination and reduce symptoms of urinary incontinence.
5. Migraine prevention: Electric stimulation can be used as a preventive treatment for migraines by applying electrical impulses to specific nerves in the head and neck.

It is important to note that electric stimulation should only be administered under the guidance of a qualified healthcare professional, as improper use can cause harm or discomfort.

Touch perception, also known as tactile perception, refers to the ability to perceive and interpret sensations resulting from mechanical stimulation of the skin and other tissues. This sense is mediated by various receptors in the skin, such as Meissner's corpuscles, Pacinian corpuscles, Merkel's disks, and Ruffini endings, which detect different types of stimuli like pressure, vibration, and texture.

The information gathered by these receptors is transmitted to the brain through sensory neurons, where it is processed and integrated with other sensory information to create a coherent perception of the environment. Touch perception plays a crucial role in many aspects of daily life, including object manipulation, social interaction, and the appreciation of various forms of sensory pleasure.

Brain mapping is a broad term that refers to the techniques used to understand the structure and function of the brain. It involves creating maps of the various cognitive, emotional, and behavioral processes in the brain by correlating these processes with physical locations or activities within the nervous system. Brain mapping can be accomplished through a variety of methods, including functional magnetic resonance imaging (fMRI), positron emission tomography (PET) scans, electroencephalography (EEG), and others. These techniques allow researchers to observe which areas of the brain are active during different tasks or thoughts, helping to shed light on how the brain processes information and contributes to our experiences and behaviors. Brain mapping is an important area of research in neuroscience, with potential applications in the diagnosis and treatment of neurological and psychiatric disorders.

Size perception in a medical context typically refers to the way an individual's brain interprets and perceives the size or volume of various stimuli. This can include visual stimuli, such as objects or distances, as well as tactile stimuli, like the size of an object being held or touched.

Disorders in size perception can occur due to neurological conditions, brain injuries, or certain developmental disorders. For example, individuals with visual agnosia may have difficulty recognizing or perceiving the size of objects they see, even though their eyes are functioning normally. Similarly, those with somatoparaphrenia may not recognize the size of their own limbs due to damage in specific areas of the brain.

It's important to note that while 'size perception' is not a medical term per se, it can still be used in a medical or clinical context to describe these types of symptoms and conditions.

Photic stimulation is a medical term that refers to the exposure of the eyes to light, specifically repetitive pulses of light, which is used as a method in various research and clinical settings. In neuroscience, it's often used in studies related to vision, circadian rhythms, and brain function.

In a clinical context, photic stimulation is sometimes used in the diagnosis of certain medical conditions such as seizure disorders (like epilepsy). By observing the response of the brain to this light stimulus, doctors can gain valuable insights into the functioning of the brain and the presence of any neurological disorders.

However, it's important to note that photic stimulation should be conducted under the supervision of a trained healthcare professional, as improper use can potentially trigger seizures in individuals who are susceptible to them.

The spinal cord is a major part of the nervous system, extending from the brainstem and continuing down to the lower back. It is a slender, tubular bundle of nerve fibers (axons) and support cells (glial cells) that carries signals between the brain and the rest of the body. The spinal cord primarily serves as a conduit for motor information, which travels from the brain to the muscles, and sensory information, which travels from the body to the brain. It also contains neurons that can independently process and respond to information within the spinal cord without direct input from the brain.

The spinal cord is protected by the bony vertebral column (spine) and is divided into 31 segments: 8 cervical, 12 thoracic, 5 lumbar, 5 sacral, and 1 coccygeal. Each segment corresponds to a specific region of the body and gives rise to pairs of spinal nerves that exit through the intervertebral foramina at each level.

The spinal cord is responsible for several vital functions, including:

1. Reflexes: Simple reflex actions, such as the withdrawal reflex when touching a hot surface, are mediated by the spinal cord without involving the brain.
2. Muscle control: The spinal cord carries motor signals from the brain to the muscles, enabling voluntary movement and muscle tone regulation.
3. Sensory perception: The spinal cord transmits sensory information, such as touch, temperature, pain, and vibration, from the body to the brain for processing and awareness.
4. Autonomic functions: The sympathetic and parasympathetic divisions of the autonomic nervous system originate in the thoracolumbar and sacral regions of the spinal cord, respectively, controlling involuntary physiological responses like heart rate, blood pressure, digestion, and respiration.

Damage to the spinal cord can result in various degrees of paralysis or loss of sensation below the level of injury, depending on the severity and location of the damage.

Color perception refers to the ability to detect, recognize, and differentiate various colors and color patterns in the visual field. This complex process involves the functioning of both the eyes and the brain.

The eye's retina contains two types of photoreceptor cells called rods and cones. Rods are more sensitive to light and dark changes and help us see in low-light conditions, but they do not contribute much to color vision. Cones, on the other hand, are responsible for color perception and function best in well-lit conditions.

There are three types of cone cells, each sensitive to a particular range of wavelengths corresponding to blue, green, and red colors. The combination of signals from these three types of cones allows us to perceive a wide spectrum of colors.

The brain then interprets these signals and translates them into the perception of different colors and hues. It is important to note that color perception can be influenced by various factors, including cultural background, personal experiences, and even language. Some individuals may also have deficiencies in color perception due to genetic or acquired conditions, such as color blindness or cataracts.

Olfactory perception refers to the ability to perceive and recognize odors or smells, which is mediated by olfactory receptor neurons located in the nasal cavity. These neurons detect and transmit information about chemical compounds present in the inhaled air to the brain, specifically to the primary olfactory cortex, where the perception of smell is processed and integrated with other sensory inputs. Olfactory perception plays a crucial role in various aspects of human behavior, including food selection, safety, and emotional responses.

The cerebral cortex is the outermost layer of the brain, characterized by its intricate folded structure and wrinkled appearance. It is a region of great importance as it plays a key role in higher cognitive functions such as perception, consciousness, thought, memory, language, and attention. The cerebral cortex is divided into two hemispheres, each containing four lobes: the frontal, parietal, temporal, and occipital lobes. These areas are responsible for different functions, with some regions specializing in sensory processing while others are involved in motor control or associative functions. The cerebral cortex is composed of gray matter, which contains neuronal cell bodies, and is covered by a layer of white matter that consists mainly of myelinated nerve fibers.

Transient receptor potential vanilloid (TRPV) cation channels are a subfamily of transient receptor potential (TRP) channels, which are non-selective cation channels that play important roles in various physiological processes such as nociception, thermosensation, and mechanosensation. TRPV channels are activated by a variety of stimuli including temperature, chemical ligands, and mechanical forces.

TRPV channels are composed of six transmembrane domains with intracellular N- and C-termini. The TRPV subfamily includes six members: TRPV1 to TRPV6. Among them, TRPV1 is also known as the vanilloid receptor 1 (VR1) and is activated by capsaicin, the active component of hot chili peppers, as well as noxious heat. TRPV2 is activated by noxious heat and mechanical stimuli, while TRPV3 and TRPV4 are activated by warm temperatures and various chemical ligands. TRPV5 and TRPV6 are primarily involved in calcium transport and are activated by low pH and divalent cations.

TRPV channels play important roles in pain sensation, neurogenic inflammation, and temperature perception. Dysfunction of these channels has been implicated in various pathological conditions such as chronic pain, inflammatory diseases, and cancer. Therefore, TRPV channels are considered promising targets for the development of novel therapeutics for these conditions.

Opioid mu receptors, also known as mu-opioid receptors (MORs), are a type of G protein-coupled receptor that binds to opioids, a class of chemicals that include both natural and synthetic painkillers. These receptors are found in the brain, spinal cord, and gastrointestinal tract, and play a key role in mediating the effects of opioid drugs such as morphine, heroin, and oxycodone.

MORs are involved in pain modulation, reward processing, respiratory depression, and physical dependence. Activation of MORs can lead to feelings of euphoria, decreased perception of pain, and slowed breathing. Prolonged activation of these receptors can also result in tolerance, where higher doses of the drug are required to achieve the same effect, and dependence, where withdrawal symptoms occur when the drug is discontinued.

MORs have three main subtypes: MOR-1, MOR-2, and MOR-3, with MOR-1 being the most widely studied and clinically relevant. Selective agonists for MOR-1, such as fentanyl and sufentanil, are commonly used in anesthesia and pain management. However, the abuse potential and risk of overdose associated with these drugs make them a significant public health concern.

Treatment outcome is a term used to describe the result or effect of medical treatment on a patient's health status. It can be measured in various ways, such as through symptoms improvement, disease remission, reduced disability, improved quality of life, or survival rates. The treatment outcome helps healthcare providers evaluate the effectiveness of a particular treatment plan and make informed decisions about future care. It is also used in clinical research to compare the efficacy of different treatments and improve patient care.

An "attitude to health" is a set of beliefs, values, and behaviors that an individual holds regarding their own health and well-being. It encompasses their overall approach to maintaining good health, preventing illness, seeking medical care, and managing any existing health conditions.

A positive attitude to health typically includes:

1. A belief in the importance of self-care and taking responsibility for one's own health.
2. Engaging in regular exercise, eating a balanced diet, getting enough sleep, and avoiding harmful behaviors such as smoking and excessive alcohol consumption.
3. Regular check-ups and screenings to detect potential health issues early on.
4. Seeking medical care when necessary and following recommended treatment plans.
5. A willingness to learn about and implement new healthy habits and lifestyle changes.
6. Developing a strong support network of family, friends, and healthcare professionals.

On the other hand, a negative attitude to health may involve:

1. Neglecting self-care and failing to take responsibility for one's own health.
2. Engaging in unhealthy behaviors such as sedentary lifestyle, poor diet, lack of sleep, smoking, and excessive alcohol consumption.
3. Avoidance of regular check-ups and screenings, leading to delayed detection and treatment of potential health issues.
4. Resistance to seeking medical care or following recommended treatment plans.
5. Closed-mindedness towards new healthy habits and lifestyle changes.
6. Lack of a support network or reluctance to seek help from others.

Overall, an individual's attitude to health can significantly impact their physical and mental well-being, as well as their ability to manage and overcome any health challenges that may arise.

Psychological stress is the response of an individual's mind and body to challenging or demanding situations. It can be defined as a state of emotional and physical tension resulting from adversity, demand, or change. This response can involve a variety of symptoms, including emotional, cognitive, behavioral, and physiological components.

Emotional responses may include feelings of anxiety, fear, anger, sadness, or frustration. Cognitive responses might involve difficulty concentrating, racing thoughts, or negative thinking patterns. Behaviorally, psychological stress can lead to changes in appetite, sleep patterns, social interactions, and substance use. Physiologically, the body's "fight-or-flight" response is activated, leading to increased heart rate, blood pressure, muscle tension, and other symptoms.

Psychological stress can be caused by a wide range of factors, including work or school demands, financial problems, relationship issues, traumatic events, chronic illness, and major life changes. It's important to note that what causes stress in one person may not cause stress in another, as individual perceptions and coping mechanisms play a significant role.

Chronic psychological stress can have negative effects on both mental and physical health, increasing the risk of conditions such as anxiety disorders, depression, heart disease, diabetes, and autoimmune diseases. Therefore, it's essential to identify sources of stress and develop effective coping strategies to manage and reduce its impact.

"Health Knowledge, Attitudes, and Practices" (HKAP) is a term used in public health to refer to the knowledge, beliefs, assumptions, and behaviors that individuals possess or engage in that are related to health. Here's a brief definition of each component:

1. Health Knowledge: Refers to the factual information and understanding that individuals have about various health-related topics, such as anatomy, physiology, disease processes, and healthy behaviors.
2. Attitudes: Represent the positive or negative evaluations, feelings, or dispositions that people hold towards certain health issues, practices, or services. These attitudes can influence their willingness to adopt and maintain healthy behaviors.
3. Practices: Encompass the specific actions or habits that individuals engage in related to their health, such as dietary choices, exercise routines, hygiene practices, and use of healthcare services.

HKAP is a multidimensional concept that helps public health professionals understand and address various factors influencing individual and community health outcomes. By assessing and addressing knowledge gaps, negative attitudes, or unhealthy practices, interventions can be designed to promote positive behavior change and improve overall health status.

"Sex characteristics" refer to the anatomical, chromosomal, and genetic features that define males and females. These include both primary sex characteristics (such as reproductive organs like ovaries or testes) and secondary sex characteristics (such as breasts or facial hair) that typically develop during puberty. Sex characteristics are primarily determined by the presence of either X or Y chromosomes, with XX individuals usually developing as females and XY individuals usually developing as males, although variations and exceptions to this rule do occur.

The "attitude of health personnel" refers to the overall disposition, behavior, and approach that healthcare professionals exhibit towards their patients or clients. This encompasses various aspects such as:

1. Interpersonal skills: The ability to communicate effectively, listen actively, and build rapport with patients.
2. Professionalism: Adherence to ethical principles, confidentiality, and maintaining a non-judgmental attitude.
3. Compassion and empathy: Showing genuine concern for the patient's well-being and understanding their feelings and experiences.
4. Cultural sensitivity: Respecting and acknowledging the cultural backgrounds, beliefs, and values of patients.
5. Competence: Demonstrating knowledge, skills, and expertise in providing healthcare services.
6. Collaboration: Working together with other healthcare professionals to ensure comprehensive care for the patient.
7. Patient-centeredness: Focusing on the individual needs, preferences, and goals of the patient in the decision-making process.
8. Commitment to continuous learning and improvement: Staying updated with the latest developments in the field and seeking opportunities to enhance one's skills and knowledge.

A positive attitude of health personnel contributes significantly to patient satisfaction, adherence to treatment plans, and overall healthcare outcomes.

Afferent neurons, also known as sensory neurons, are a type of nerve cell that conducts impulses or signals from peripheral receptors towards the central nervous system (CNS), which includes the brain and spinal cord. These neurons are responsible for transmitting sensory information such as touch, temperature, pain, sound, and light to the CNS for processing and interpretation. Afferent neurons have specialized receptor endings that detect changes in the environment and convert them into electrical signals, which are then transmitted to the CNS via synapses with other neurons. Once the signals reach the CNS, they are processed and integrated with other information to produce a response or reaction to the stimulus.

I'm sorry for any confusion, but "weight perception" is not a standard medical term with a widely accepted or specific definition in the field of medicine. It seems more related to the general psychological concept of how individuals perceive and judge their own weight or the weight of objects. If you have a more specific context or situation related to this term, I would be happy to help further!

A cross-over study is a type of experimental design in which participants receive two or more interventions in a specific order. After a washout period, each participant receives the opposite intervention(s). The primary advantage of this design is that it controls for individual variability by allowing each participant to act as their own control.

In medical research, cross-over studies are often used to compare the efficacy or safety of two treatments. For example, a researcher might conduct a cross-over study to compare the effectiveness of two different medications for treating high blood pressure. Half of the participants would be randomly assigned to receive one medication first and then switch to the other medication after a washout period. The other half of the participants would receive the opposite order of treatments.

Cross-over studies can provide valuable insights into the relative merits of different interventions, but they also have some limitations. For example, they may not be suitable for studying conditions that are chronic or irreversible, as it may not be possible to completely reverse the effects of the first intervention before administering the second one. Additionally, carryover effects from the first intervention can confound the results if they persist into the second treatment period.

Overall, cross-over studies are a useful tool in medical research when used appropriately and with careful consideration of their limitations.

Neural pathways, also known as nerve tracts or fasciculi, refer to the highly organized and specialized routes through which nerve impulses travel within the nervous system. These pathways are formed by groups of neurons (nerve cells) that are connected in a series, creating a continuous communication network for electrical signals to transmit information between different regions of the brain, spinal cord, and peripheral nerves.

Neural pathways can be classified into two main types: sensory (afferent) and motor (efferent). Sensory neural pathways carry sensory information from various receptors in the body (such as those for touch, temperature, pain, and vision) to the brain for processing. Motor neural pathways, on the other hand, transmit signals from the brain to the muscles and glands, controlling movements and other effector functions.

The formation of these neural pathways is crucial for normal nervous system function, as it enables efficient communication between different parts of the body and allows for complex behaviors, cognitive processes, and adaptive responses to internal and external stimuli.

An illusion is a perception in the brain that does not match the actual stimulus in the environment. It is often described as a false or misinterpreted sensory experience, where the senses perceive something that is different from the reality. Illusions can occur in any of the senses, including vision, hearing, touch, taste, and smell.

In medical terms, illusions are sometimes associated with certain neurological conditions, such as migraines, brain injuries, or mental health disorders like schizophrenia. They can also be a side effect of certain medications or substances. In these cases, the illusions may be a symptom of an underlying medical condition and should be evaluated by a healthcare professional.

It's important to note that while illusions are often used in the context of entertainment and art, they can also have serious implications for individuals who experience them frequently or as part of a medical condition.

In medical terms, the skin is the largest organ of the human body. It consists of two main layers: the epidermis (outer layer) and dermis (inner layer), as well as accessory structures like hair follicles, sweat glands, and oil glands. The skin plays a crucial role in protecting us from external factors such as bacteria, viruses, and environmental hazards, while also regulating body temperature and enabling the sense of touch.

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Castañeda-Hernández GC, Bach-y-Rita P (August 2003). "Volume transmission and pain perception". ScientificWorldJournal. 3: 677- ... relief of pain, or control of symptoms, such as tremor seen in movement disorders like Parkinson's disease. The therapies ...
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The phrase also relates to the ability to control the perception of pain that one may or may not be experiencing. "mind over ... Wiech, Katja; Ploner, Markus; Tracey, Irene (1 August 2008). "Neurocognitive aspects of pain perception". Trends in Cognitive ... our committee could find no scientific justification for the existence of phenomena such as extrasensory perception, mental ...
Androstadienone negatively influences[how?] the perception of pain in women. Women tend to react positively after ...
Derr, Robert F. (29 August 1991). "Pain perception in decapitated rat brain". Life Sciences. 49 (19): 1399-1402. doi:10.1016/ ... The sword was expected to be used upon the slightest sign that the practitioner might yield to pain and cry out-avoiding ... unable to perceive distress and pain. It was estimated that this point was reached within 3-4 seconds, correlating closely with ... although it is disputed as to whether such activity implies that pain is perceived), and a 2010 study reported that ...
Adler, Georg; Gattaz, Wagner F (1993). "Pain perception threshold in major depression". Biological Psychiatry. 34 (10): 687-689 ... Mental state, memory, mental illness, fatigue, and other factors can alter perception. When related to motion in any of the ... Defining and measuring sensory thresholds requires setting the sensitivity limit such that the perception observations lead to ... Detection theory Odor detection threshold Perception Sensory analysis Smith, Christopher U. M. (20 November 2008). Biology of ...
... contributing to the perception of pain; regulating cell growth; controlling blood pressure; and modulating the regional flow of ... Pain-The cytokines increase COX-2 activity. This elevates levels of PGE2, sensitizing pain neurons. Heat-PGE2 is also a potent ... and in the peripheral nervous system inhibit or reduce pain perception. The reduction in AA-derived eicosanoids and the ... Lim JY, Park CK, Hwang SW (2015). "Biological Roles of Resolvins and Related Substances in the Resolution of Pain". BioMed ...
Short, C.E. (1998). "Fundamentals of pain perception in animals". Applied Animal Behaviour Science. 59 (1-3): 125-133. doi: ... Pain in invertebrates is a contentious issue. Although there are numerous definitions of pain, almost all involve two key ... Pain is therefore a private, emotional experience. Pain cannot be directly measured in other animals, including other humans; ... they felt pain. It has been questioned why the inference does not then follow that a cockroach experiences pain when it writhes ...
Park, Thomas (2017). "Pain, Perception, and the Appearance-Reality Distinction". Philosophical Analysis. 2017 (38): 205-237. ... This is the source of the so-called "problem of perception". It consists in the fact that the features ascribed to perception ... auditory perception or haptic perception. It is usually held that the objects perceived this way are ordinary material objects ... While perception is usually a reliable source of information for the practical matters of our everyday affairs, it can also ...
It may have been more advantageous to link the pain and pleasure perceptions together to be able to reduce pain to gain a ... "Human brain mechanisms of pain perception and regulation in health and disease" (PDF). European Journal of Pain. 9 (4): 463-484 ... Activity in many parts of the brain is associated with pain perception. Some of the known parts for the ascending pathway ... There is strong evidence of biological connections between the neurochemical pathways used for the perception of both pain and ...
Tidwell, James H. and Allan, Geoff L. Sneddon, LU (2009). "Pain perception in fish: indicators and endpoints". ILAR Journal. 50 ... "Do fish feel pain? Not as humans do, study suggests". ScienceDaily. 8 August 2013. Retrieved 2 August 2017. Lund, V; Mejdell, ... Historically, some doubted that fish could experience pain. Laboratory experiments have shown that fish do react to painful ... Oidtmann, B; Hoffman, RW (July-August 2001). "Pain and suffering in fish". Berliner und Münchener Tierärztliche Wochenschrift. ...
Harkins, S. W.; Price, D. D.; Martelli, M. (1986-01-01). "Effects of Age on Pain Perception: Thermonociception". Journal of ... The perception that those in this stage of development of life undergo a so-called midlife crisis is a largely false one. ...
... would experience pain and suffering..." In 2015, Brown wrote "A review of the evidence for pain perception strongly suggests ... Sometimes a distinction is made between "physical pain" and "emotional" or "psychological pain". Emotional pain is the pain ... "Ontogeny and phylogeny of facial expression of pain". Pain. 156 (5): 798-799. doi:10.1097/j.pain.0000000000000133. PMID ... Henriksen, S., Vaagland, H., Sundt-Hansen, L., May, R. and Fjellheim, A. (2003). "Consequences of pain perception in fish for ...
Guénette SA, Giroux MC, Vachon P (2013). "Pain perception and anaesthesia in research frogs". Experimental Animals. 62 (2): 87- ... Otic pain (earache) Surgical or procedural local anesthesia Relief of skin pain caused by sunburn, ingrown toenails, ... Benzocaine is indicated to treat a variety of pain-related conditions. It may be used for: Local anesthesia of oral and ... The action potential is propagated down the nerve toward the central nervous system, which interprets this as pain. Benzocaine ...
"Although the evidence for pain perception is equivocal..." "...the evidence certainly does not preclude the possibility of pain ... Sometimes a distinction is made between "physical pain" and "emotional" or "psychological pain". Emotional pain is the pain ... "Ontogeny and phylogeny of facial expression of pain". Pain. 156 (5): 798-799. doi:10.1097/j.pain.0000000000000133. PMID ... If true, this would also rule out pain perception in most mammals, all birds, reptiles and cephalopods. However, the Cambridge ...
Sneddon LU (28 August 2012). "Pain perception in fish: Why critics cannot accept the scientific evidence for fish pain" (PDF). ... Sometimes a distinction is made between "physical pain" and "emotional" or "psychological pain". Emotional pain is the pain ... Studies indicating that fish can feel pain were confusing nociception with feeling pain, says Rose. "Pain is predicated on ... Sneddon LU (2011). "Pain perception in fish evidence and implications for the use of fish". Journal of Consciousness Studies. ...
Cannabis alters mental activity, memory, and pain perception. One who is under the influence of cannabis may (or may not) ... Opioid abuse may result in decreased production of endorphins in the brain, natural pain relievers whose effects may be ... are obviously dependent on sense perceptions, and vary accordingly as they do.{{cite news}}: CS1 maint: others (link) Mailhouse ...
Meditation has been shown to reduce pain perception. An intervention known as mindfulness-based pain management (MBPM) has been ... "Psychobiological correlates of improved mental health in patients with musculoskeletal pain after a mindfulness-based pain ... Kabat-Zinn, Jon (2013). Full Catastrophe Living: Using the Wisdom of Your Body and Mind to Face Stress, Pain, and Illness (2nd ... In 2013, researchers found moderate evidence that meditation can reduce anxiety, depression, and pain, but no evidence that it ...
July 2015). "Transcriptional regulator PRDM12 is essential for human pain perception". Nature Genetics. 47 (7): 803-8. doi: ... did not experience pain during childbirth, did not experience pain from degeneration of a hip that required hip replacement ... a patient cannot describe the intensity or type of pain. Indifference to pain means that the patient can perceive the stimulus ... Because feeling physical pain is vital for survival, CIP is an extremely dangerous condition. It is common for people with the ...
LXA4 and 15-epi-LXA4, when introduced by intrathecal administration into rodents, suppress the perception of inflammatory pain ... reduce perception of pain due to inflammation. LXA4 and 15-epi-LTA4 also act by mobilizing transcription factors that regulate ... and suppress the perception of inflammatory pain in rodents. One or more of the lipoxins or their metabolically resistant ... and inflammation-based pain and hyperalgesia. Lipoxins have protective effects in animal models of infection-based inflammation ...
People with HSAN5 lose the ability to feel pain, heat, and cold. Deep pain perception, the feeling of pain from injuries to ... February 19, 2004). "A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception". Hum. Mol. Genet. ... The ability to sense all pain (including visceral pain) is absent, resulting in repeated injuries including: oral self- ... Type 5, congenital insensitivity to pain with partial anhidrosis, also manifests with congenital insensitivity to pain & ...
These mechanoreceptors monitor pressure, heat, perception of pain, and texture. Touch is a form of nonverbal communication that ... deals with the insertion of needles into the skin in order to affect one's mood and perception of pain. Reiki, a Japanese touch ... and pain. Psychosensory therapy has its roots in traditional Chinese medicine in addition to energy psychology. Some important ... in the hope this might alleviate pain. According to Ruden, touch facilitates an increase in calming chemicals like serotonin, ...
This process, called nociception, usually causes the perception of pain. They are found in internal organs as well as on the ... Problems with mechanoreceptors lead to disorders such as: Neuropathic pain - a severe pain condition resulting from a damaged ... Nociceptors are responsible for processing pain and temperature changes. The burning pain and irritation experienced after ... to pain perception Osmoreceptors respond to the osmolarity of fluids (such as in the hypothalamus) Proprioceptors provide the ...
GABA usually diminishes the perception of pain. The method by which GABA modulates synaptic transmission from primary afferent ... They found that pharmacologically blocking GABA receptors actually enhanced the perception of pain; in other words, ... One study showed that animals without a specific type of GABA receptor on their nociceptors were hypersensitive to pain, thus ... Price TJ, Cervero F, Gold MS, Hammond DL, Prescott SA (April 2009). "Chloride regulation in the pain pathway". Brain Research ...
van der Kolk, BA; Greenberg, MS; Orr, S; Pittman, RK (1989). "Pain Perception and endogenous opioids in Post Traumatic Stress ... psychiatrist Bessel van der Kolk on how to recover from our deepest pain". The Guardian. Archived from the original on ...
Klepstad P, Maurset A, Moberg ER, Oye I (October 1990). "Evidence of a role for NMDA receptors in pain perception". European ...
This process, called nociception, usually causes the perception of pain. They are found in internal organs, as well as on the ... "Experiencing Sensation and Perception - Chapter 1: What is Sensation and Perception?" (PDF). p. 1.6. Retrieved May 16, 2013. ... Experiencing Sensation and Perception. Pearson Education, Limited, 2009. p. 12.3[permanent dead link] Julius, David. "How ... Rapidly adapting receptors have small receptive fields and underlie the perception of slip. Pacinian receptors have large ...
This leads to increased pain perception in areas under inflammation. In acquired immunity, NGF is produced by the Thymus as ...
... has a modulatory effect on pain processing. Particularly strong evidence comes from animal models. Here, we review recent ... Oxytocin and Pain Perception: From Animal Models to Human Research Neuroscience. 2018 Sep 1:387:149-161. doi: 10.1016/j. ... The human literature is therefore scanned thoroughly and different approaches to study the effects of OT on pain perception in ... Human studies investigating the influence of OT on pain perception are less numerous and have revealed less consistent results ...
... pain interference, and pain behavior. Interventions designed to dec... ... poor sleep in the prior week increased pain intensity, ... Pain perception (pain intensity, pain interference, and pain ... Discussion: In this study, poor sleep in the prior week increased pain intensity, pain interference, and pain behavior. ... pain interference, and pain behavior. There was a trend toward sleep efficiency, and increased pain intensity and sleep ...
Kuypers KP A low dose of lysergic acid diethylamide decreases pain perception in healthy volunteers J Psychopharmacol 2020 ... "A low dose of lysergic acid diethylamide decreases pain perception in healthy volunteers". ... "A low dose of lysergic acid diethylamide decreases pain perception in healthy volunteers" J Psychopharmacol. 2020 Jul 28; ... is an ergot alkaloid derivative with psychedelic properties that has been implicated in the management of persistent pain. ...
... the cutaneous pressure pain perception threshold (CPPPT) and the deep pressure pain perception threshold (DPPPT) at the foot ... The diagnostic value of measuring pressure pain perception in patients with diabetes mellitus *Tobias Wienemann ... Wienemann T, Chantelau E. The diagnostic value of measuring pressure pain perception in patients with diabetes mellitus. Swiss ... Pain. 1988;34:1-10. *Krumova E K, Geber C, Westermann A, Maier C. Neuropathic pain: is quantitative sensory testing helpful? ...
It could also increase pain alleviation for other cattle diseases because producer perceptions on disbudding-related pain are ... PhD study shows that dairy producers who have knowledge of pain and who think pain alleviation is beneficial and important are ... Hot-iron disbudding is very painful and causes severe pain-related distress and behavioural changes in calves. ... also more prone to administer pain alleviation for disbudded calves. ...
... beliefs and perceptions. Methods: We analyzed 896,867 cleaned tweets about LBP between January 1, 2014, and December 31, 2018. ... Low back pain (LBP) remains the leading cause of disability worldwide. A better understanding of the beliefs regarding LBP and ... Investigating Individuals Perceptions Regarding the Context Around the Low Back Pain Experience: Topic Modeling Analysis of ... Investigating Individuals Perceptions Regarding the Context Around the Low Back Pain Experience: Topic Modeling Analysis of ...
Although there are some differences between countries in the management of pain, the impact of pain and perceptions of ... Musculoskeletal pain in Europe: its impact and a comparison of population and medical perceptions of treatment in eight ... Musculoskeletal pain in Europe: its impact and a comparison of population and medical perceptions of treatment in eight ... Some people with pain have never sought medical help despite being in constant/daily pain. Those who do seek help receive ...
The pain self-efficacy questionnaire: taking pain into account. Eur J Pain 2007;11:153-63. doi:10.1016/j.ejpain.2005.12.008. ... e-Health and chronic pain management: current status and developments. Pain 2010;151:18-21. doi:10.1016/j.pain.2010.07.014. ... Factors related to seeking health care among adolescents with musculoskeletal pain. Pain 2011;152:896-903. doi:10.1016/j.pain. ... Beyond nociception: the imprecision hypothesis of chronic pain. Pain 2015;156:35-8. doi:10.1016/j.pain.0000000000000014. ...
... Information about the Resource. Schema.org Name(s): Controlled Heading Identifier: * http://id.worldcat.org/ ...
The effect of anticipation of a sweet taste on heat pain threshold was also assessed.,/ns4:p,,ns4:p, ,ns4:bold,Results,/ns4: ... However, there are no published studies examining the effects of sweet substances on heat pain thresholds and percept in adult ... Alternatively, sweet tastes may have a specific effect on pain tolerance rather than the threshold and acute percept measures ... on the warm detection or heat pain threshold (43.3±0.8, 43.2±0.8 vs 43.0±0.8°C). Anticipation of a sweet substance similarly ...
Parsing pain perception between nociceptive representation and magnitude estimation. / Baliki, M. N.; Geha, P. Y.; Apkarian, A ... Given that pain perception is fundamentally an assessment of stimulus intensity, it must necessarily engage such a central ... Baliki, M. N., Geha, P. Y., & Apkarian, A. V. (2009). Parsing pain perception between nociceptive representation and magnitude ... Baliki, M. N. ; Geha, P. Y. ; Apkarian, A. V. / Parsing pain perception between nociceptive representation and magnitude ...
"Pain Perception" by people in this website by year, and whether "Pain Perception" was a major or minor topic of these ... "Pain Perception" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Do health beliefs affect pain perception after pectus excavatum repair? Pediatr Surg Int. 2018 Dec; 34(12):1363-1367. ... Below are the most recent publications written about "Pain Perception" by people in Profiles. ...
The brain is the final gatekeeper to the perception of pain. In other words, pain may not always correlate with the amount of ... I - Perception of pain. Go Back to the Homepage / I - Perception of pain ... The brain is the final gatekeeper to the perception of pain. In other words, pain may not always correlate with the amount of ... I am not telling you all to ignore your pain, but do know that it is possible to reduce the sensitivity to pain by thinking ...
Perry Nickelston: Changing Perceptions of Pain Dr. Perry Nickelston, host of the Stop Chasing Pain podcast, found his calling ... Perry Nickelston: Changing Perceptions of Pain Dr. Perry Nickelston, host of the Stop Chasing Pain podcast, found his calling ...
SIQUEIRA, Hilze Benigno de Oliveira Moura et al. Pain perception in adolescents with cancer: phenomenological research. Rev. ... The results showed the perception associated with significant experience of existential pain situations, as the following ... coexisting with pain; (4) realizing the pain negatively. The adolescents with cancer understood their painful experience in ... Palabras clave : Pain; Neoplasms; Adolescent; Phenomenology. · resumen en Español , Portugués · texto en Portugués · Portugués ...
Topics covered include: colour perception; face recognition; perception of pain and age related changes in perception. Students ... Spatial Vision, Temporal Vision, Depth Perception, Biopsychology of Vision, Role of Attention in Perception. ... Understand the role of visual illusions in the study of perception.. Conceptual. Understand. Understand the basics of ... The course will focus on theoretical approaches in terms of lightness perception and attention. ...
Pain management in dental care Dental Pain Management Strategies ... Patient perception of a dental experience - discomfort vs ... "Id rather experience any pain except tooth ache.". The age old portrayal of dental appointments and dentists even in the ... Many patients with dental fear describe the helplessness and pain they may have been subjected to which caused them to not go ... Man being a pleasure-seeking organism definitely does not want to ever encounter pain or danger. We are built to avoid that ...
Barriers include misconceptions about pain perception, lack of knowledge about potential long-term consequences of pain in ... Pain Assessment. Optimal pain management begins with an accurate and thorough assessment of pain. Self-reporting is considered ... 4 Barriers include misconceptions about pain perception; lack of knowledge about potential long-term consequences of pain in ... Pain Perception. Fetal neuronal connections between spinal dorsal horn cells and sensory neurons occur early in gestation and ...
... through Pain Visual Analog Scale (VAS). Methods: Four electronic databases (Pubmed, Medline, CENTRAL and Scholar) were s... ... This systematic review aimed to compare the pain discomfort levels between InvisalignⓇ aligners comparing with traditional ... Patients anticipation of pain and pain-related side effects, and their perception of pain as a result of orthodontic treatment ... Perception of pain as a result of orthodontic treatment with fixed appliances. Eur. J. Orthod. 1996;18(4):349-57. Available at ...
The Spectrum of Pain Perception: While it is true that some individuals with cerebral palsy may experience pain, it is ... Pain Management Strategies: When pain is present in individuals with cerebral palsy, appropriate pain management strategies ... Debunking the Myth: Understanding Pain Perception in Cerebral Palsy. 17 juli 2023. Share Share Länk. ... but its association with pain is often misunderstood. Join us as we delve into the complexities of pain perception in cerebral ...
Psychophysiology / 002A26E Perception / 002A26E07 Proprioception. Interoception. Pain perception. Francis. 770 Psychology. ... Analgesia Electrical conductance Pain Habituation Human Hypnosis Skin Perception Somatosensory evoked potential Relaxation ... Pain perception, somatosensory event-related potentials and skin conductance responses to painful stimuli in high, mid, and low ... "Pain perception, somatosensory event-related potentials and skin conductance responses to painful stimuli in high, mid, and low ...
Body perception distortions and disassociation are traits common to chronic pain sufferers such as CRPS. CRPS is a syndrome in ... Hallmark study on body perception and chronic pain wins UK Arthritis Society research grant ... And with these changes in visual perception, the researchers noted, there is a modest decrease in pain. By comparison, the same ... "Chronic pain may be a lot more complex and a lot more of a whole system issue than we previously thought," says Moayedi, who ...
A 10-point scale (1-least to 10-most painful) was used to measure pain perception.. RESULTS: In men pain perception was ... There was a slight decrease in pain perception with increasing age (-0.23 +/- 0.10 points per decade, p = 0.021). The level of ... Randomized, prospective, double-blind study of the effects on pain perception of lidocaine jelly versus plain lubricant during ... In women there was no observed difference in pain perception when lidocaine jelly or plain lubricant was used (3.21 +/- 0.38 ...
Exploring perceptions of the Mentastics Trager Psychophysical Integration method in chronic pain management ... Exploring perceptions of the Mentastics Trager Psychophysical Integration method in chronic pain management ... Serpa, Christina (2022) Exploring perceptions of the Mentastics Trager Psychophysical Integration method in chronic pain ... chronic pain, pain management, complementary alternative medicine (CAM), active movement education, Trager MD.. ...
Period Pain & Perception: When a Womans Pain is Ignored. Something thats been making headlines more often in recent months is ... Its clear that weve got a long way to go culturally when it comes to our perceptions of women, period pain, and its reception ... However, recurring period pain bring up another aspect of this question. Since women deal with pain on a regular, recurring ... One popular, though untested, belief is that continued exposure to pain builds up a sort of pain immunity, making the sufferer ...
Predicting Postoperative Pain Based on Preoperative Pain Perception: Are We Doing Better Than the Weatherman? Srinivasa N. Raja ... Srinivasa N. Raja, Troels S. Jensen; Predicting Postoperative Pain Based on Preoperative Pain Perception: Are We Doing Better ... They conclude that quantitative testing of pain perception may predict nearly half of the variance in postoperative pain ... Andersen S, Skorpen F: Variation in the COMT gene: Implications for pain perception and pain treatment. Pharmacogenomics 2009; ...
STOP CHASING PAIN by Perry Nickelston. A Vital Guide for healing your body, moving well, and regaining control of your life ... A neuroscientist and world-renowned expert in perception; his research explores the ways in which we experience the world ... By illuminating these principles of perception he has helped individuals and companies transform their approach to creativity ... explores the surprising science of creativity and unveils the unexpected relationship between perception, reality and ...
... , Busra Ucmaz* ... in the perception of pain [12]. Generally, it was stated that females suffer more from pain than males. Reporting more pain by ... forces affect pain perception, debonding was performed in an open-mouthed position. In order to avoid confusing the pain ... value of a pain stimulus and to feel helpless in the presence of pain [16]. The Pain Catastrophizing Scale is a survey that ...
  • Chronic musculoskeletal pain (MP) is a debilitating condition that affects over 100 million people in Europe and around one in four people in less developed and more developed countries world wide. (bmj.com)
  • The AAG undertook the first extensive pan-European survey to quantify the impact of MP on quality of life, to describe current management, and to identify the beliefs and perceptions of treatment that are held by physicians and people with chronic MP. (bmj.com)
  • Body perception distortions and disassociation are traits common to chronic pain sufferers such as CRPS. (utoronto.ca)
  • By comparison, the same illusion in patients with osteoarthritis markedly reduces chronic pain. (utoronto.ca)
  • While the researchers hope to pinpoint why these patients lose ownership of their hands and other limbs, and reverse disassociation, they also hope to discover new regions that can serve as therapeutic biomarkers in the brain that may be responsible for chronic pain and body distortion. (utoronto.ca)
  • Chronic pain may be a lot more complex and a lot more of a whole system issue than we previously thought," says Moayedi, who hopes that non-pharmacological brain stimulation therapies are one outcome of the research. (utoronto.ca)
  • If we can find the part of the brain that changes from normal to diseased, we can then potentially target these with brain stimulation to treat chronic pain," he says. (utoronto.ca)
  • This study brings together research from the fields of chronic pain management, complementary alternative medicine (CAM), and somatic practices to enlighten the chronic pain population, massage therapists, and manual therapists about a novel and lesser-known framework of movement principles within the Trager Psychophysical Integration MD method (Mentastics). (mun.ca)
  • This exploratory and descriptive study examined individuals' perceptions of the Mentastics technique to help support people living with persistent chronic pain. (mun.ca)
  • Results have the potential to offer a new way of supporting and offering a lesser-known self-care protocol for mobility maintenance and shaping the future of massage education practices in the field of chronic pain. (mun.ca)
  • This study demonstrated the high potential of the Mentastics technique, in possibly aiding with the alleviation of perceived pain levels, within the demographic of individuals dealing with chronic pain. (mun.ca)
  • However, we know that chronic pain (not menstrual pain) can actually increase sensitivity in sufferers, and that more women than men experience chronic pain. (rubylove.com)
  • Significant progress during this period include advances in our knowledge of the pain signaling pathways and the plasticity of the peripheral and central nervous systems leading to chronic pain, the acceptance of pain as the "fifth vital sign," and the development of standards for pain evaluation and care by the Joint Commission on Accreditation of Health Care Organizations. (silverchair.com)
  • QST of patients with chronic pain has provided valuable mechanistic insights. (silverchair.com)
  • Drawing on a panel of United Kingdom practitioners' expertise, this study aimed to investigate their perceptions of CFs during the management of patients presenting with chronic low back pain (LBP). (biomedcentral.com)
  • Clinically, cannabinoids may be critical to chronic pain treatment not only to help reduce pain, but also to reduce the need for high doses of addictive painkillers. (cedclinic.com)
  • Considering cannabis for chronic pain? (cedclinic.com)
  • the two most commonly used markers being 3 months and 6 months since the onset of pain, though some theorists and researchers have placed the transition from acute to chronic pain at 12 months. (wikipedia.org)
  • 93 Others apply "acute" to pain that lasts less than 30 days, "chronic" to pain of more than six months' duration, and "subacute" to pain that lasts from one to six months. (wikipedia.org)
  • Chronic pain may be classified as "cancer-related" or "benign. (wikipedia.org)
  • Chronic pain enhances this cortico-cortical connection, as manifested by an increased number of ACC neurons that respond to S1 inputs and the magnified contribution of these neurons to the nociceptive response in the ACC. (iasp-pain.org)
  • An amygdalo-parabrachial pathway regulates pain perception and chronic pain. (iasp-pain.org)
  • We have recently reported that chronic pain is associated with amplified activity of PB neurons in a rat model of neuropathic pain. (iasp-pain.org)
  • Animals with pain after chronic constriction injury of the infraorbital nerve (CCI-Pain) displayed higher spontaneous and evoked activity in PB neurons, and a dramatic increase in after-discharges-responses that far outlast the stimulus-compared to controls. (iasp-pain.org)
  • We find that the efficacy of this CeA-LPB pathway is suppressed in chronic pain. (iasp-pain.org)
  • These findings demonstrate that the CeA-LPB pathway is critically involved in pain regulation, and in the pathogenesis of chronic pain. (iasp-pain.org)
  • We show that this pathway regulates the activity of pain-related neurons in PB, and that, in chronic pain, this inhibitory pathway is suppressed, and that this suppression is causally related to pain perception. (iasp-pain.org)
  • We propose that this amygdalo-parabrachial pathway is a key regulator of both chronic and acute pain, and a novel target for pain relief. (iasp-pain.org)
  • There are two types of pain: acute and chronic . (medlineplus.gov)
  • It usually goes away, though sometimes it can turn into chronic pain. (medlineplus.gov)
  • Chronic pain lasts for a long time, and can cause severe problems. (medlineplus.gov)
  • Posttraumatic stress disorder (PTSD) and chronic pain often co-occur and exacerbate each other. (iucc.ac.il)
  • Previously, patients with PTSD with chronic pain were found to demonstrate a unique paradoxical pain profile: hyperresponsiveness together with hyposensitivity to pain. (iucc.ac.il)
  • Chronic pain intensity was associated with anxiety, anxiety sensitivity, and pain catastrophizing. (iucc.ac.il)
  • It appears that reduced conscious attention toward incoming stimuli, resulting from dissociation, causes delayed response in pain threshold measurement, whereas biases toward threatening stimuli and decreased inhibition, possibly caused by increased anxiety, are responsible for the intensification of experimental and chronic pain. (iucc.ac.il)
  • The paradoxical facets of PTSD and their particular influences over pain perception seem to reinforce the coexistence of PTSD and chronic pain, and should be considered when treating traumatized individuals. (iucc.ac.il)
  • Perspective This article provides new information regarding the underlying mechanism of the coexistence of PTSD and chronic pain. (iucc.ac.il)
  • This knowledge could help to provide better management of PTSD and chronic pain among individuals in the aftermath of trauma. (iucc.ac.il)
  • 6 Patients with SCD may not always appear to be in pain because they have often developed a high pain tolerance due to a lifetime of chronic pain. (cdc.gov)
  • Pain has sensory and emotional components and is often classified as acute or chronic. (msdmanuals.com)
  • A personal or family history of chronic pain can often illuminate the current problem. (msdmanuals.com)
  • Whether family members perpetuate chronic pain (eg, by constantly asking about the patient's health) should be considered. (msdmanuals.com)
  • The prediction of diabetic neuropathic foot ulceration using vibration perception thresholds. (smw.ch)
  • Rolke R, Campbell KA, Magerl W, Treede RD. Deep pain thresholds in the distal limbs of healthy human subjects. (smw.ch)
  • However, there are no published studies examining the effects of sweet substances on heat pain thresholds and percept in adult humans. (ox.ac.uk)
  • Healthy adult volunteers (n=27, aged 18-48 years) were recruited to a controlled, double-blind, randomised, cross-over study to characterise the effect of tasting solutions of equivalent sweetness (10% sucrose and 0.016% sucralose) on warm detection and heat pain thresholds and the percept ratings of painfully hot stimuli. (ox.ac.uk)
  • Tasting either sucrose or sucralose had no significant effect on the percept of an individually titrated hot stimulus (54.5±4.2 and 54.9±3.2 vs 53.2±3.5 for water, 0-100 visual analogue scale), on the warm detection or heat pain threshold (43.3±0.8, 43.2±0.8 vs 43.0±0.8°C). Anticipation of a sweet substance similarly did not affect heat pain thresholds. (ox.ac.uk)
  • There's been some debate (though unfortunately no clinical studies) about whether or not women tend to have higher pain thresholds than men. (rubylove.com)
  • The participants completed the Beck Depression Inventory and Pain Catastrophizing Scales before removing the brackets, and pressure pain thresholds were detected by using the algometer device. (jrmds.in)
  • Patients with PTSD had higher pain thresholds and higher pain ratings to suprathreshold stimuli than control individuals. (iucc.ac.il)
  • Pain thresholds were positively associated with dissociation levels and negatively associated with anxiety sensitivity levels. (iucc.ac.il)
  • However, pain thresholds, VAS measures, and tactile thresholds were not consistently affected by sweet intake. (mun.ca)
  • females reported lower pain thresholds and pain tolerances and rated the pain as more intense and more unpleasant than did males. (mun.ca)
  • Krumova E K, Geber C, Westermann A, Maier C. Neuropathic pain: is quantitative sensory testing helpful? (smw.ch)
  • A new definition of neuropathic pain. (smw.ch)
  • Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Standardized protocol and reference values. (smw.ch)
  • Test-retest and interobserver reliability of quantitative sensory testing according to the protocol of the German Research Network on Neuropathic Pain (DFNS):A multi-centre study. (smw.ch)
  • 4,5 QST has been used for prediction or early identification of neuropathies to classify the sensory abnormalities in peripheral and central neuropathic pain states, 6 as a tool in more accurately diagnosing fibromyalgia, 7 and in illuminating patient characteristics that are associated with treatment outcomes. (silverchair.com)
  • It is a type of neuropathic pain. (wikipedia.org)
  • Functional neurorehabilitation promotes neural reorganization by stimulating subjects without deep pain perception, leading to a faster recovery when compared to spontaneous recovery, and achieving fewer compensatory errors, or even deviations to neuropathic or adaptive pain pathways, such as spasticity. (mdpi.com)
  • The patient's perception of pain and other factors may influence the clinical presentation. (msdmanuals.com)
  • Dr. Perry Nickelston, host of the Stop Chasing Pain podcast, found his calling in the health and wellness field as a result of an unforgettable experience. (podcastmagazine.com)
  • Instead, measuring the vibration perception threshold (VPT) by 64 Hz graduated Rydel-Seiffer tuning fork has become standard clinical practice to screen for neuropathy and ulcer proneness. (smw.ch)
  • Studies are needed to identify optimal strategies for translating current knowledge into improved clinical practices in pediatric pain management. (uspharmacist.com)
  • Randomized clinical trials (RCTs) and case-control studies comparing pain perception through VAS in patients treated with Invisalign aligners and with labial appliances were included. (researchsquare.com)
  • Optimal shaping of contextual factors (CFs) during clinical encounters may be associated with analgesic responses in treatments for musculoskeletal pain. (biomedcentral.com)
  • After the first dose of the two-shot Moderna regimen, 87 percent of people under 65 years old and 74 percent of those 65 and up in clinical trials reported localized pain, echoing research that shows a decline in immune reactivity with age. (nationalgeographic.com)
  • Inhibitory control and simple reaction time were assessed via the Flanker task and clinical reaction time test, pain and fatigue were assessed using Borg's category-ratio scale (CR-10), and the state-trait anxiety inventory Y-1 test assessed anxiety. (uninsubria.it)
  • Thus, the use of psychological techniques is a cornerstone in pain management and must be reflected in clinical guidelines . (bvsalud.org)
  • Hundreds of clinical reports exist concerning the use of TENS for various types of conditions, such as low back pain (LBP), myofascial and arthritic pain, sympathetically mediated pain, bladder incontinence , neurogenic pain, visceral pain, and postsurgical pain . (medscape.com)
  • Over the last decades, the gender of investigator as well as participant has been found to influence pain perception in both preclinical and clinical studies. (lu.se)
  • Conclusions: Main findings of lower pain intensity reported by males to a female than to a male investigator early after surgery in this paired crossover study in mixed postoperative patients, indicate that potential impact of investigator gender on pain perception should be considered and further evaluated in clinical bedside practice. (lu.se)
  • Aim: To report the semiological conduct taken in three clinical cases of orofacial pain in patients with head and neck cancer and to describe the therapeutic approach adopted, discussing the analgesic ladder as set forth by the World Health Organization (WHO). (bvsalud.org)
  • Here, we review recent advances in animal research on the analgesic effects of OT and discuss possible target sites of OT within descending and ascending pain pathways in the brain. (nih.gov)
  • 5 The only pathways documented to be deficient in prematures are those of the descending inhibitory controllers of pain. (uspharmacist.com)
  • Hyperalgesia and allodynia have been reported in the literature as a result of pain in prematures and neonates, presumably a result of modification of neuronal pathways in response to painful stimuli. (uspharmacist.com)
  • Mapping Cortical Integration of Sensory and Affective Pain Pathways. (iasp-pain.org)
  • The study found that fetuses start developing the biological pathways related to pain sensation at this stage of gestation, but there is not enough evidence to suggest that they can actually experience pain in the way we understand it. (yourtango.com)
  • These results demonstrate that pain perception is due to the transformation of nociceptive representation into subjective magnitude assessment within the insula. (northwestern.edu)
  • The parabrachial (PB) complex mediates both ascending nociceptive signaling and descending pain modulatory information in the affective/emotional pain pathway. (iasp-pain.org)
  • The results of laboratory studies suggest that electrical stimulation delivered by a TENS unit reduces pain through nociceptive inhibition at the presynaptic level in the dorsal horn, thus limiting its central transmission. (medscape.com)
  • Perception of nociceptive pain. (lu.se)
  • Almost two-thirds of participants with persistent musculoskeletal pain reported comorbid mental health conditions. (bmj.com)
  • Results Participants described their daily experiences of living with persistent musculoskeletal pain, their fears and the challenges imposed by the invisibility of pain, and the two-way relationship between their pain and mental well-being. (bmj.com)
  • Conclusions Young people living with persistent musculoskeletal pain described the absence of age-appropriate pain services and clearly articulated their perceptions on the role of, and opportunities provided by, digital technologies to connect with and support improved pain healthcare. (bmj.com)
  • In-depth interviews with 23 young people with persistent musculoskeletal pain recruited through purposeful sampling from across Australian jurisdictions. (bmj.com)
  • Pain, musculoskeletal and skin disorders. (bangor.ac.uk)
  • In addition to the spinal cord being a direct target of the neuropeptide, OT has also been shown to modulate the neuronal activity of limbic and cortical brain regions, which play a major role in the cognitive and emotional processing of pain. (nih.gov)
  • Moreover, we also address how OT might alleviate pain by influencing socio-emotional components in humans. (nih.gov)
  • The complexity of the sensory and emotional aspects of pain, particularly in pathologic cases, makes it highly unlikely that one single measure, be it psychosocial or biomechanical, could predict all aspects of acute or more persistent postoperative pain. (silverchair.com)
  • The aim of this study was to investigate the effects of physiological-emotional state on perceived pain during bracket debonding. (jrmds.in)
  • Although few correlations were found statistically significant, there was no remarkable relationship between the physiological-emotional state and debonding pain. (jrmds.in)
  • Pain is a subjective phenomenon and it is argued that it is affected by many individual variations such as age, gender, individual pain threshold, present emotional state and stress, cultural differences, and previous pain experiences [ 2 ]. (jrmds.in)
  • Spouses who were accurate in their perceptions of their partner's level of pain during a log-carrying task responded less negatively and provided emotional support that was more satisfying to patients. (psu.edu)
  • The International Association for the Study of Pain defines pain as "an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage. (wikipedia.org)
  • The arousal and emotional perception scores of odors with terpene-type oil were significantly higher than odors with ester-alcohol type. (frontiersin.org)
  • The habits of fragrance usage also significantly influenced some of the odors' subjective intensity and emotional perception ratings. (frontiersin.org)
  • In addition, familiarity and pleasantness were positively correlated, and emotional perception and subjective intensity also showed a weak correlation. (frontiersin.org)
  • Fibromyalgia (fi·bro·my·al·gi·a) is a condition that causes pain all over the body (also referred to as widespread pain), sleep problems, fatigue, and often emotional and mental distress. (cdc.gov)
  • Pain clinics can place pets in waiting, evaluation, and therapy rooms to improve patients' emotional and physical well-being. (wakeup-world.com)
  • Finnish dairy producers estimated disbudding pain to be severe and producer estimation of pain severity caused by disbudding was correlated with their sensitivity to pain caused by different cattle diseases in general. (helsinki.fi)
  • Acyloxyacyl hydrolase modulates pelvic pain severity. (childrensmercy.org)
  • This study of older patients with osteoarthritis and their spouses examined concordance between patients' and spouses' reports of patients' pain severity and the association of concordance with support and caregiving outcomes. (psu.edu)
  • Examples include being perceived as drug-seeking and being doubted when they report the severity of their pain. (cdc.gov)
  • Pain severity should be assessed before and after potentially painful interventions. (msdmanuals.com)
  • And with these changes in visual perception, the researchers noted, there is a modest decrease in pain. (utoronto.ca)
  • Across a number of different diseases, including diabetes, arthritis and certain respiratory infections, women in the study reported feeling more pain than men, the researchers said. (livescience.com)
  • Because pain is subjective, the researchers can't know for sure whether women, in fact, experience more pain than men. (livescience.com)
  • But most haven't looked at how intense the pain is, and many have not included enough people to be able to detect differences between the sexes in pain perception, the researchers said. (livescience.com)
  • In all, the researchers assessed sex differences in reported pain for more than 250 diseases and conditions. (livescience.com)
  • Researchers conducted a study to record dogs' effects on pain patients in a clinic. (wakeup-world.com)
  • Pain is a subjective phenomenon and it is highly affected by individual variations. (jrmds.in)
  • Ultimately, pain is subjective and typically relies on self-reporting, even in medical practice. (yourtango.com)
  • However, aromachology research has found that odor subjective perception was relevant to the possible impact of odor ( Herz, 2009 ). (frontiersin.org)
  • 8 The assumption that increased distractibility in children indicates a lack of pain may lead to the incorrect conclusion that pediatric patients do not perceive pain as noxious stimuli and therefore need minimal analgesia. (uspharmacist.com)
  • Pain is a distressing feeling often caused by intense or damaging stimuli. (wikipedia.org)
  • They convey the tactile stimuli to the spinal cord leading to the perception of a painful experience 6 . (nature.com)
  • We conclude that further investigating specific OT and OT-sensitive circuits, which modulate pain processing especially in primates, will improve our understanding of OT-analgesic effects. (nih.gov)
  • QUESTION UNDER STUDY: Repetitive skin trauma and reduced pressure pain sensation are necessary components of plantar ulcer risk in patients with diabetic neuropathy. (smw.ch)
  • We therefore set up a diagnostic case-control study to compare the VPT, the cutaneous pressure pain perception threshold (CPPPT) and the deep pressure pain perception threshold (DPPPT) at the foot sole in diabetic patients with and without past or present painless plantar ulcer. (smw.ch)
  • 55% or fewer patients who have seen a doctor are currently receiving prescription treatment for their pain. (bmj.com)
  • For years, we as dental professionals have identified the biggest challenge to treating our patients has been this all-encompassing fear of going to the dentist that prevents so many people from seeking care at the right time, this in fact makes the occurrence of dental pain a definite reality. (dentalreach.today)
  • In regard to the type of material, SmartTrackⓇ aligners appear to give significantly better comfort for orthodontic patients than previous standard material, being that 3 days after appliance's insertion this pain differential becomes significant, and this difference is more pronounced at 7 days. (researchsquare.com)
  • Conclusion: Patients treated with Invisalign experience less pain discomfort than those treated with fixed appliances and consume less analgesics. (researchsquare.com)
  • While it has yet to be determined if patients with osteoarthritis also suffer from body perception distortion, one part of the study will work to determine if this is the case. (utoronto.ca)
  • There is no clear evidence that intraurethral lidocaine jelly decreases pain and/or makes rigid cystoscopy more tolerable for patients. (qxmd.com)
  • The bill passed by the U.S. Congress and signed by President Clinton dedicated this decade to improving professional training in pain care, educating patients about pain management, providing access to pain treatment, and expanding pain research. (silverchair.com)
  • Although considerable advances have been made in the management of perioperative pain, a significant proportion of patients still suffer from inadequate pain control. (silverchair.com)
  • A better understanding of the predictors of postsurgical pain will help in identifying the subset of patients who are likely to require additional care to optimize their perioperative pain management. (silverchair.com)
  • 2 The challenge in predicting the patients who will experience the most postoperative pain or who require the most treatment is that the risk factors for perioperative pain include not only quantitative sensory measures but also psychosocial and genetic factors. (silverchair.com)
  • Their article reported that preoperative QST may also predict up to 54% of the variance in acute postoperative pain across individual patients. (silverchair.com)
  • Pain is a side effect that is frequently experienced during orthodontic procedure and causes patients to avoid treatment. (jrmds.in)
  • Although different percentages have been reported, studies have shown that almost 90% of patients undergoing orthodontic treatment experienced pain at different stages of the treatment [ 1 - 5 ]. (jrmds.in)
  • Patel said that 8% of orthodontic patients had chosen to discontinue treatment because of pain [ 7 ]. (jrmds.in)
  • Reporting more pain by female patients was associated with their fragility and sensitivity to pain [ 13 ]. (jrmds.in)
  • Patients and spouses independently viewed videotapes of the patient performing simulated household tasks and provided ratings of patients' pain. (psu.edu)
  • Spousal overestimation of patients' pain was the most common type of nonconcordance. (psu.edu)
  • The new study included information from more than 11,000 patients whose pain scores were recorded in electronic medical records at Stanford Hospital and Clinics between 2007 and 2010. (livescience.com)
  • Patients were asked to rate their pain on a scale of zero (no pain) to 10 (worst pain imaginable). (livescience.com)
  • One study found that eight days after amputation, 72% of patients had phantom limb pain, and six months later, 67% reported it. (wikipedia.org)
  • Despite large efforts to test analgesics in animal models, only a handful of new pain drugs have shown efficacy in patients. (iasp-pain.org)
  • The analgesic effect of pregabalin was consistently robust across every etiology/measure tested, even for pain conditions that have not responded to pregabalin in patients. (iasp-pain.org)
  • To improve patients ' ability to deal with pain in conjunction with dental extraction, the dental team should ensure better and individually tailored information about the treatment . (bvsalud.org)
  • When TENS is used analgesically, patients are instructed to try different frequencies and intensities to find those that provide them with the best pain control. (medscape.com)
  • Methods: In this prospective observational paired crossover study, two investigators of opposite genders independently obtained individually reported pain intensity levels with a visual analogue scale in a mixed cohort of adult postoperative study patients at Skåne University Hospital in Malmö, Sweden. (lu.se)
  • Pain intensity levels did not differ between female and male study patients (P = 0.210). (lu.se)
  • Patients with SCD frequently have difficulty getting proper treatment when they arrive in the ED. One study found that they wait 25% longer to see a doctor in the ED than do other patients, even though people with SCD tend to have worse pain. (cdc.gov)
  • Inaccurate provider beliefs and lack of pain management protocols in the ED may prolong pain episodes for patients with SCD. (cdc.gov)
  • Research shows that adults with SCD experience significant delay in receiving pain medications when they go to the ED. 7 In one study, patients with SCD waited an average of 30 minutes longer before receiving pain medications compared to patients with kidney stones, which can cause pain comparable to pain from SCD. (cdc.gov)
  • Overview of Pain Pain is the most common reason patients seek medical care. (msdmanuals.com)
  • Pain Adverse effects are common in patients receiving any cancer therapy, particularly cytopenias, gastrointestinal effects, and tumor lysis and cytokine release syndromes. (msdmanuals.com)
  • In some patients, secondary gain (external, incidental benefits of a disorder-eg, time off, disability payments) may contribute to pain or pain-related disability. (msdmanuals.com)
  • In verbal patients, self-report is the gold standard, and external signs of pain or distress (eg, crying, wincing, rocking) are secondary. (msdmanuals.com)
  • Results: The most commonly reported complaint was orofacial pain in the three male patients with head and neck squamous cell carcinoma. (bvsalud.org)
  • Insular cortex responses similarly segregated to a pain-specific area and an area (extending to the lateral prefrontal cortex) conjointly representing perceived magnitudes for pain and vision. (northwestern.edu)
  • 5,6 Although infants have more generalized responses to pain compared with older children, their ability to perceive and react to pain has been documented. (uspharmacist.com)
  • Furthermore, modulation of this S1→ACC projection regulates aversive responses to pain. (iasp-pain.org)
  • Olfactory perception, and especially affective responses of odors, is highly flexible, but some mechanisms involved in this flexibility remain to be elucidated. (frontiersin.org)
  • Pain and rashes are normal responses to foreign substances being injected into our bodies. (nationalgeographic.com)
  • The good news, experts say, is that arm pain and even rashes are normal responses to the injection of foreign substances into our bodies. (nationalgeographic.com)
  • PB neurons in CCI-Pain animals showed a reduction in inhibitory, GABAergic inputs. (iasp-pain.org)
  • Within a framework for a new socio-ecological narrative that considers opposition (such as fighting) and collaboration (cooperative learning) as carriers of self-control and pain perception inhibition, we investigated the acute effects of a judo-specific session on cognitive (inhibitory control and simple reaction time), perceptual (pain and fatigue), affective (anxiety) and physiological (hormone profile) domains. (uninsubria.it)
  • Pain perception (pain intensity, pain interference, and pain behavior) is measured by the Patient-Reported Outcomes Measurement Information System during monthly in-person visits. (nursingcenter.com)
  • Increased awakenings after sleep onset in the prior week is associated with increased pain intensity, pain interference, and pain behavior. (nursingcenter.com)
  • There was a trend toward sleep efficiency, and increased pain intensity and sleep efficiency predicted increased pain interference and pain behavior. (nursingcenter.com)
  • In this study, poor sleep in the prior week increased pain intensity, pain interference, and pain behavior. (nursingcenter.com)
  • Given that pain perception is fundamentally an assessment of stimulus intensity, it must necessarily engage such a central module. (northwestern.edu)
  • Objectives of this study were to test the hypotheses that pain intensity levels early after acute or scheduled in- or out-hospital surgery are lower when evaluated by a female investigator, and higher when reported by a female patient. (lu.se)
  • Pain intensity was evaluated through the visual analogic scale (VAS). (bvsalud.org)
  • After the diagnosis and treatment of orofacial pain, the pain intensity and drug intake were reduced. (bvsalud.org)
  • Conclusion: The precise and individual diagnosis of orofacial pain allows for a more effective pain management, thus reducing the pain intensity, the number of complaints, and the amount of medicine. (bvsalud.org)
  • But scientific conclusions about when a fetus can feel pain may be different from the information you receive from legislators and activists. (yourtango.com)
  • Sweet induced-analgesia is thought to operate through an endogenous opioid system whereby sweet consumption causes the release of opioids into the CNS, resulting in pain-inhibition. (mun.ca)
  • Fetal pain perception, or misperception, is often peddled out by anti-choice campaigners as a means of deterring people from abortion. (yourtango.com)
  • Why do people get the facts about fetal pain perception wrong? (yourtango.com)
  • Fetal pain perception may or may not alter a person's perspective on abortion and their choice to terminate their pregnancy, but we at least owe women access to the available facts when we attempt to infringe on their right to choose. (yourtango.com)
  • Lysergic acid diethylamide (LSD) is an ergot alkaloid derivative with psychedelic properties that has been implicated in the management of persistent pain. (erowid.org)
  • Preoperative pain represents a consistent risk factor for development of persistent postoperative pain for a series of surgical conditions, such as limb amputation, breast surgery, hysterectomy, thoracotomy, and hernia repair. (silverchair.com)
  • In this informative and intriguing article, we explore the common misconception surrounding pain in individuals with cerebral palsy (CP). (konfidostore.com)
  • Join us as we delve into the complexities of pain perception in cerebral palsy, dispel misconceptions, and shed light on the experiences of individuals living with CP. (konfidostore.com)
  • The Spectrum of Pain Perception: While it is true that some individuals with cerebral palsy may experience pain, it is essential to understand that pain perception can vary widely among individuals. (konfidostore.com)
  • However, secondary factors such as muscle stiffness, contractures, or associated conditions can contribute to pain experiences in some individuals. (konfidostore.com)
  • Factors Influencing Pain in Cerebral Palsy: Several factors can contribute to the presence or absence of pain in individuals with cerebral palsy. (konfidostore.com)
  • Secondary Conditions and Pain: Individuals with cerebral palsy may be more prone to certain secondary conditions that can cause pain. (konfidostore.com)
  • Communication Challenges: One of the complexities in assessing pain in individuals with cerebral palsy is the potential communication challenges they may face. (konfidostore.com)
  • Some individuals may have difficulty expressing their pain due to limited verbal communication skills. (konfidostore.com)
  • Pain Management Strategies: When pain is present in individuals with cerebral palsy, appropriate pain management strategies should be considered. (konfidostore.com)
  • While some individuals may experience pain due to specific factors, others may have minimal or no pain. (konfidostore.com)
  • Cerebral palsy itself is not inherently a painful condition, but individuals with CP may experience pain due to associated factors. (konfidostore.com)
  • By addressing secondary conditions, utilizing pain management strategies, and fostering a supportive environment, we can help individuals with cerebral palsy live comfortable and fulfilling lives. (konfidostore.com)
  • By illuminating these principles of perception he has helped individuals and companies transform their approach to creativity and innovation. (stopchasingpain.com)
  • The hormonal response reduces individuals' perception of pain and enhances positive feelings. (wakeup-world.com)
  • Does instantaneous blood glucose affect vibration perception threshold measurement using biothesiometer? (smw.ch)
  • The effect of anticipation of a sweet taste on heat pain threshold was also assessed. (ox.ac.uk)
  • Alternatively, sweet tastes may have a specific effect on pain tolerance rather than the threshold and acute percept measures assayed in this study. (ox.ac.uk)
  • Pain sensitivity was assessed with four pain measures: pain threshold, pain tolerance, and visual analogue scale (VAS) ratings of painintensity and unpleasantness. (mun.ca)
  • A number of factors, including a person's mood and whether they take pain medication , likely influence how much pain they say they're in. (livescience.com)
  • CBD isolate may affect a person's appetite, mood, and pain perception. (medicalnewstoday.com)
  • There was a slight decrease in pain perception with increasing age (-0.23 +/- 0.10 points per decade, p = 0.021). (qxmd.com)
  • Professionals found a 23% decrease in pain throughout the study. (wakeup-world.com)
  • 1,2 Although progress has been made in the availability of pain-assessment tools and the understanding of pain pharmacotherapy, research suggests that hospitalized children are still receiving inadequate analgesia. (uspharmacist.com)
  • However, the present results also indicate that this sweet-induced analgesia is influenced by a number of factors, including the method of pain induction, the type of pain measure, and the gender of the subjects. (mun.ca)
  • Paraplegia, the loss of sensation and voluntary motor control after serious spinal cord damage, may be accompanied by girdle pain at the level of the spinal cord damage, visceral pain evoked by a filling bladder or bowel, or, in five to ten per cent of paraplegics, phantom body pain in areas of complete sensory loss. (wikipedia.org)
  • Options for treating disbudding-related pain during the procedure, and for 24 hours subsequently, are well known, but continued pain and its management are not much studied in calves after disbudding. (helsinki.fi)
  • Thus, is suggested that psychologists, nurses and physicians pay attention the history of life, the duration of hospitalization and the pain expression this stage of life, so that, based on the reports, health professionals may think about treatments and management strategies that can relieve your pain. (bvsalud.org)
  • Optimal pain management begins with an accurate and thorough assessment of pain. (uspharmacist.com)
  • Prompt identification and management of these conditions can help alleviate pain and improve overall well-being. (konfidostore.com)
  • A comprehensive approach, involving healthcare professionals and individualized care plans, is essential for effective pain management. (konfidostore.com)
  • This includes providing accessible healthcare services, promoting early intervention for secondary conditions, and ensuring effective pain management. (konfidostore.com)
  • When CB 1 receptors detect cannabinoids, they alter how we perceive pain and pleasure, and how these feelings can be manipulated by a placebo effect, making the ECS a promising area of study for pain management . (cedclinic.com)
  • In the context of pain management, cannabinoid agonists increase the anticipation that opioids will relieve pain, while the opioids actually relieve the pain. (cedclinic.com)
  • In addition to medical treatment, people can manage their fibromyalgia with the self-management strategies described below, which are proven to reduce pain and disability, so they can pursue the activities important to them. (cdc.gov)
  • See Pain Management: Concepts, Evaluation, and Therapeutic Options , a Critical Images slideshow, to help assess pain and establish efficacious treatment plans. (medscape.com)
  • Yet, they deserve appropriate pain management. (cdc.gov)
  • Blocking either CB 1 receptors or opioid receptors decreases the rise in pain tolerance, and blocking both receptors abolishes this effect entirely. (cedclinic.com)
  • Hot-iron disbudding is very painful and causes severe pain-related distress and behavioural changes in calves. (helsinki.fi)
  • A 10-point scale (1-least to 10-most painful) was used to measure pain perception. (qxmd.com)
  • Participants have a higher pain tolerance when they are told that a painful tourniquet will build muscle compared to when they are told that the tourniquet has no benefits. (cedclinic.com)
  • When painful peripheral stimulation occurs, however, the information carried by C fibers reaches the T cells and opens the gate, allowing pain transmission centrally to the thalamus and cortex, where it is interpreted as pain. (medscape.com)
  • Usually, the electrodes are initially placed on the skin over the painful area, but other locations (eg, over cutaneous nerves, trigger points, acupuncture sites) may give comparable or even better pain relief. (medscape.com)
  • 1 critically review the literature on the predictive factors for postoperative pain based on preoperative quantitative testing of a patient's basal pain perception. (silverchair.com)
  • They conclude that quantitative testing of pain perception may predict nearly half of the variance in postoperative pain experience. (silverchair.com)
  • However, from a clinician's perspective, we are still only as good as the weatherman in predicting an individual's postoperative pain experience. (silverchair.com)
  • suggests that despite the complexity of pain perception, preoperative quantitative sensory testing (QST) may be a clinically relevant predictor of postoperative pain. (silverchair.com)
  • 3 These findings that QST and heat hyperalgesia can be predictive of postoperative pain are consistent with the existing literature in other areas of pain research. (silverchair.com)
  • Background: Postoperative pain is common but often difficult to assess, and there are many potential confounders. (lu.se)
  • The human literature is therefore scanned thoroughly and different approaches to study the effects of OT on pain perception in humans are discussed. (nih.gov)
  • Objective: The aim of the study was to examine a predictive model of the relationship between poor sleep and pain perception among community-dwelling older adults with mild cognitive impairment. (nursingcenter.com)
  • PhD study shows that dairy producers who have knowledge of pain and who think pain alleviation is beneficial and important are also more prone to administer pain alleviation for disbudded calves. (helsinki.fi)
  • This exploratory descriptive study developed at the Hospital for an inner city of São Paulo aimed to understand how adolescents with cancer perceived the pain experience. (bvsalud.org)
  • The hallmark study will for the first time run a brain imaging study identifying brain regions involved in body perception distortions in people suffering from osteoarthritis and a rare condition, Complex Regional Pain Syndrome (CRPS). (utoronto.ca)
  • The group will begin this new phase of the study by running osteoarthritis and CRPS participants with body perception and disassociation disorders through visuo-haptic illusions, simultaneously imaging those subjects' brains with functional MRI. (utoronto.ca)
  • Randomized, prospective, double-blind study of the effects on pain perception of lidocaine jelly versus plain lubricant during outpatient rigid cystoscopy. (qxmd.com)
  • In a study evaluating the level of patient discomfort at the time of debonding, Williams and Bishara stated that the level of debonding pain was significantly influenced by two factors: the mobility of the tooth and the direction of application of force [ 8 ]. (jrmds.in)
  • When a woman falls ill, her pain may be more intense than a man's, a new study suggests. (livescience.com)
  • The study is one of the largest to examine sex differences in human pain perception. (livescience.com)
  • Whatever the reason, I think it's important to be aware of this pain discrepancy between men and women and look into it further," said study researcher Linda Liu, a doctoral student in Stanford University Biomedical Informatics program. (livescience.com)
  • The study was published online Jan. 12 in the Journal of Pain. (livescience.com)
  • It could be that women assign different numbers to the level of pain they perceive compared with men, said Roger B. Fillingim, a pain researcher at the University of Florida College of Dentistry, who was not involved with the new study. (livescience.com)
  • Results from the study indicate that CBD isolate is only effective against pain and swelling at a specific dose. (medicalnewstoday.com)
  • This study investigated the odor perceptions of several essential oils used in aromatherapy with emotion regulation functions among college students. (frontiersin.org)
  • The results indicated that chemical type, but not concentration, significantly influenced the odor perception and there was no interaction between the two factors in this study. (frontiersin.org)
  • This research was designed to study the efficacy of placebo and laughter therapy on pain perception, sleep quality, and post-traumatic growth in recovering drug abusers. (jmchemsci.com)
  • A grounded theory study on Swedish 10 to 16-year-olds' perceptions of pain in conjunction with orthodontically indicated tooth extraction. (bvsalud.org)
  • This study aims to explore and describe children 's experiences and/or thoughts regarding pain in conjunction with tooth extraction . (bvsalud.org)
  • It is important to acknowledge and understand this barrier of perceived pain, from a psychological as well as technological stand point, that will help us create awareness for a better patient experience among our patient populations. (dentalreach.today)
  • Past research suggests a number of factors contribute to perceptions of pain level, including hormones, genetics and psychological factors, which may vary between men and women, Fillingim said. (livescience.com)
  • 4. Psychological changes in pain perception and reporting behavior. (cdc.gov)
  • Also, nearly 80% of female participants believe that a fetus can perceive pain prior to the third trimester, compared to just 56% of males. (yourtango.com)
  • 9 Anecdotal reports and animal data indicate that repeated exposure to pain may result in patterns of self-destructive behavior, attention-deficit/hyperactivity disorder, impaired social skills, anxiety, and stress-related disorders in older children and adolescents. (uspharmacist.com)
  • The term back injury is used throughout the text to refer to all back disorders, injuries, or pain. (cdc.gov)
  • Pain is an integrated sensory and affective experience. (iasp-pain.org)
  • Our results thus define a cortical circuit that plays a potentially important role in integrating sensory and affective pain signals. (iasp-pain.org)
  • From primary care physicians' perceptions, MP appears to be well managed. (bmj.com)
  • Krishnan stated that the primary causes of poor cooperation were pain, functional and aesthetic impairment caused by the appliances [ 2 ]. (jrmds.in)
  • Here, we investigate the projection from the primary somatosensory cortex (S1), which encodes the sensory pain information, to the anterior cingulate cortex (ACC), a key area for processing pain affect, in freely behaving rats. (iasp-pain.org)
  • Our primary objective was to describe design characteristics and outcomes of studies testing the efficacy of pregabalin in behavioral models of pain. (iasp-pain.org)
  • The results demonstrate that Invisalign aligners seems to be associated with significantly less pain than fixed appliances at 7 days after beginning the orthodontic treatment, although at 1 and 3 days the pain experience was similar in both orthodontics appliances. (researchsquare.com)
  • Overall, Invisalign promotes better pain and discomfort experience for the patient in the course of orthodontic treatment. (researchsquare.com)
  • O'Connor has revealed that pain was the most unpleasant situation during treatment and fourth among major fears and apprehensions prior to orthodontic treatment [ 6 ]. (jrmds.in)
  • CB1 and opioid receptors may work together to regulate this pain-relieving placebo effect. (cedclinic.com)
  • Therefore, CB 1 and opioid receptors together could be most effective at driving reward-related pain tolerance. (cedclinic.com)
  • It contains sensory receptors for touch, pressure and pain and also has respiratory, excretory and osmoregulatory functions. (coe.int)
  • Prostaglandins interact directly with local pain receptors. (nationalgeographic.com)
  • The mechanism of pain perception has individual peripheral receptors and includes a complex and chemically unique set of central circuits 7 . (nature.com)
  • Symptom science research in the direction of how poor sleep affects pain among older adults, especially those with mild cognitive impairment, is needed for the development of targeted sleep interventions to reduce pain and potentially delay/reduce the risk for Alzheimer's disease in this population. (nursingcenter.com)
  • Therefore, more knowledge and research are needed on the recognition of calves pain after hot-iron disbudding, on the duration of pain and on options to treat it in an effective, safe and practical way. (helsinki.fi)
  • Research is also needed on producer knowledge and attitudes towards pain in calves and their decision-making in connection with pain alleviation. (helsinki.fi)
  • The aim of this course is to consider a range of approaches to human perception, from historical beginnings to recent innovative research. (abdn.ac.uk)
  • WE are nearing the end of the Decade of Pain Control and Research (2000-2010). (silverchair.com)
  • Women also reported feeling more pain in the neck (for conditions such as torticollis, in which the neck muscles twist or spasm) and sinuses (during sinus infections) than did men, a result not found by previous research. (livescience.com)
  • Future research is needed to find out the exact causes of pain perception differences, and which ones would be best to target for more effective pain control, Fillingim said. (livescience.com)
  • While CBD isolate may provide pain relief, research indicates that a full-spectrum CBD product may be even more effective because cannabidiol acts synergistically with THC to boost its analgesic effects. (medicalnewstoday.com)
  • Still it should be noted that, as the nervous system is still in development prior to the 27-week mark, some research does suggest fetuses might feel pain at 24 weeks. (yourtango.com)
  • Findings were presented in two descriptive and analytical sections: the descriptive section addressed the status of each variable in the statistical sample and in the analytical section, the relationship between the independent variables with each of the three dependent variables of the research, including pain perception, sleep quality, and post-traumatic growth, was measured. (jmchemsci.com)
  • Still, pain research in dentistry has mainly been performed on adults using quantitative methods while research on the child 's perspective is scarce. (bvsalud.org)
  • I'd rather experience any pain except tooth ache. (dentalreach.today)
  • Effective communication to set expectations, adequate anesthesia and raising awareness about prevention can ensure a successful result so the patient doesn't experience pain. (dentalreach.today)
  • There is a lack of knowledge about the potential long-term consequences of pain in children, but evidence is growing that children, even young prematures, experience pain and the consequences of pain in the form of metabolic, hormonal, and hemodynamic stress. (uspharmacist.com)
  • In fact, the pain experience progression after initial archwire placement in fixed orthodontic appliance is well established in the literature, comparing multistrand stainless steel and superelastic NiTi archwires 11-18 . (researchsquare.com)
  • It's also possible the pain systems work differently in men and women, or women experience more severe forms of disease than men, he said. (livescience.com)
  • Finding biological markers for pain, such as genes or proteins, would also help take some of the subjectivity out of assessing the experience of pain, Liu said, but the identification of such markers is likely a long way off. (livescience.com)
  • Across many different diseases, women say they experience more pain than men. (livescience.com)
  • People in pain experience impaired concentration, working memory, mental flexibility, problem solving and information processing speed, and are more likely to experience irritability, depression and anxiety. (wikipedia.org)
  • others experience several bouts of pain per day, or it may reoccur less often. (wikipedia.org)
  • But how much pain you experience after a shot depends on a lot of factors. (nationalgeographic.com)
  • Children frequently experience pain and/or discomfort during dental treatment . (bvsalud.org)
  • This may help explain why CBD eases anxiety and pain in some people. (medicalnewstoday.com)
  • Experimental pain ratings were positively associated with anxiety sensitivity and negatively related to dissociation levels. (iucc.ac.il)
  • Intense sports activities affect cognitive, perceptual, and physiological domains, possibly concurring in reducing pain perception and anxiety. (uninsubria.it)
  • Acute pain is frequently associated with anxiety. (msdmanuals.com)
  • What pain means to the patient should be determined, with emphasis on psychologic issues, depression, and anxiety. (msdmanuals.com)
  • Reporting pain may be more socially acceptable than reporting anxiety or depression, and appropriate therapy often depends on identifying any additional issues. (msdmanuals.com)
  • For some people, the same inflammatory process also can cause fevers, body aches, joint pain, rashes or headaches. (nationalgeographic.com)
  • All social strata as well as the urban and tions or pathology that cause pelvic pain in rural sectors of the community were repre- conjunction with the menses. (who.int)
  • If the pain is continuous for a long period, parts of the intact body may become sensitized, so that touching them evokes pain in the phantom limb. (wikipedia.org)
  • These may include physical therapy to address muscle tightness and improve mobility, medication to alleviate pain, orthotic devices to support the body, and assistive technologies to enhance comfort and function. (konfidostore.com)
  • It is commonly observed that humans who are in pain or discomfort seek solace in the form of sweet foods and drinks. (ox.ac.uk)
  • Background: This systematic review aimed to compare the pain discomfort levels between InvisalignⓇ aligners comparing with traditional fixed appliances at multiple time points, through Pain Visual Analog Scale (VAS). (researchsquare.com)
  • The informants recalled experiences of pain and discomfort during extractions. (bvsalud.org)
  • However, instead of focussing on pain , they described an urge for more information about the procedure and what to expect in terms of pain and/or discomfort, during and/or after treatment . (bvsalud.org)
  • They stated that the levels of pain /discomfort were manageable, while the lack of information negatively affected their coping abilities , causing feelings of unease. (bvsalud.org)
  • Our findings suggest opportunities for improving the design and reporting of preclinical studies in pain. (iasp-pain.org)
  • Sujka J, St Peter S, Mueller CM. Do health beliefs affect pain perception after pectus excavatum repair? (childrensmercy.org)
  • Seven participants watched a 15-minute video introducing Mentastics and then participated in an online semi-structured interview, which asked them about their opinions and perceptions of the Mentastics technique video. (mun.ca)
  • So when it comes to the question of period pain building up a tolerance or creating hypersensitivity, the jury is still out. (rubylove.com)
  • Regardless of any actual benefits of pain, we have a higher tolerance for pain that is viewed as beneficial (for example, exercise) than pain that is viewed as aversive. (cedclinic.com)
  • Results showed that sweet palatable foods appeared to produce significant increases in females' pain tolerance to contact heat and to pressure. (mun.ca)
  • Constance remembers her tolerance to pain medications increasing to the point that some became like "Tic Tacs"-not very effective. (cdc.gov)
  • A longitudinal prospective design with 58 continuous matched sleep-pain observations of 15 older adults with mild cognitive impairment for up to 6 months was used. (nursingcenter.com)
  • Given that these symptoms are prevalent among older adults with mild cognitive impairment, sleep and pain interventions may also ameliorate some of the risk for Alzheimer's disease in this population. (nursingcenter.com)
  • Cognitive performance, perception of fatigue and physiological variables increased after randori bouts, while pain decreased. (uninsubria.it)
  • Cognition and perception symptoms included anosmia, ageusia, and altered mental status. (cdc.gov)
  • 1-4 Fewer than 25% of hospitalized children who reported moderate-to-severe pain received an appropriate scheduled opioid, and fewer than 33% of those prescribed as-needed opioids received their medication. (uspharmacist.com)
  • There are promising results from studies looking at pain treatment with both cannabinoids and opioids. (cedclinic.com)
  • Barriers include misconceptions about pain perception, lack of knowledge about potential long-term consequences of pain in children, and perceived difficulties in assessing the presence and degree of pain in children. (uspharmacist.com)
  • This finding highlights the individual differences in pain perception and response to tissue injury. (silverchair.com)
  • Meanwhile, due to individual differences, people have different perceptions of odors, which may influence the potential effects of those functional odors. (frontiersin.org)
  • From a population perspective, up to 27% of people with pain do not seek medical help and of those who do, several wait months/years before seeing a doctor. (bmj.com)
  • Some people with pain have never sought medical help despite being in constant/daily pain. (bmj.com)
  • This graph shows the total number of publications written about "Pain Perception" by people in this website by year, and whether "Pain Perception" was a major or minor topic of these publications. (childrensmercy.org)
  • Below are the most recent publications written about "Pain Perception" by people in Profiles. (childrensmercy.org)
  • Future studies, in both people and animals, should analyze their results to see whether sex differences in pain may be present, Liu said. (livescience.com)
  • Why do so many people believe that fetuses feel pain by 20-weeks? (yourtango.com)
  • People with fibromyalgia may be more sensitive to pain than people without fibromyalgia. (cdc.gov)
  • But as the United States undergoes its first mass vaccination campaign in recent memory, the widespread prevalence of arm pain is sparking questions about why certain shots hurt so much, why some people feel more pain than others, and why some don't feel any pain at all. (nationalgeographic.com)
  • Separation, archwire placement, force activation, and debonding have been expressed as the main stages of treatment that cause pain [ 2 ]. (jrmds.in)
  • In men pain perception was significantly decreased when lidocaine jelly was used (mean plus or minus standard error 3.00 +/- 0.21 versus 4.36 +/- 0.37 points, p = 0.002). (qxmd.com)
  • The results are in line with earlier findings, and reveal that sex differences in pain sensitivity may be present in many more diseases than previously thought. (livescience.com)
  • Most human studies examining gender differences in reported pain have compared the number of women with the number of men with a given condition who say they are in pain. (livescience.com)
  • However, there were no significant gender differences in most of the odor perceptions. (frontiersin.org)
  • Significant differences were observed in the areas of pain and general health. (who.int)