A genetic model of substrate deprivation therapy for a glycosphingolipid storage disorder. (1/26926)

Inherited defects in the degradation of glycosphingolipids (GSLs) cause a group of severe diseases known as GSL storage disorders. There are currently no effective treatments for the majority of these disorders. We have explored a new treatment paradigm, substrate deprivation therapy, by constructing a genetic model in mice. Sandhoff's disease mice, which abnormally accumulate GSLs, were bred with mice that were blocked in their synthesis of GSLs. The mice with simultaneous defects in GSL synthesis and degradation no longer accumulated GSLs, had improved neurologic function, and had a much longer life span. However, these mice eventually developed a late-onset neurologic disease because of accumulation of another class of substrate, oligosaccharides. The results support the validity of the substrate deprivation therapy and also highlight some limitations.  (+info)

A computational screen for methylation guide snoRNAs in yeast. (2/26926)

Small nucleolar RNAs (snoRNAs) are required for ribose 2'-O-methylation of eukaryotic ribosomal RNA. Many of the genes for this snoRNA family have remained unidentified in Saccharomyces cerevisiae, despite the availability of a complete genome sequence. Probabilistic modeling methods akin to those used in speech recognition and computational linguistics were used to computationally screen the yeast genome and identify 22 methylation guide snoRNAs, snR50 to snR71. Gene disruptions and other experimental characterization confirmed their methylation guide function. In total, 51 of the 55 ribose methylated sites in yeast ribosomal RNA were assigned to 41 different guide snoRNAs.  (+info)

Familial antiphospholipid antibody syndrome: criteria for disease and evidence for autosomal dominant inheritance. (3/26926)

OBJECTIVE: To develop diagnostic criteria for a familial form of antiphospholipid antibody syndrome (APS), identify families with >1 affected member, examine possible modes of inheritance, and determine linkage to potential candidate genes. METHODS: Family members of probands with primary APS were analyzed for clinical and laboratory abnormalities associated with APS. Families with > or =2 affected members were analyzed by segregation analysis and typed for candidate genetic markers. RESULTS: Seven families were identified. Thirty of 101 family members met diagnostic criteria for APS. Segregation studies rejected both environmental and autosomal recessive models, and the data were best fit by either a dominant or codominant model. Linkage analysis showed independent segregation of APS and several candidate genes. CONCLUSION: Clinical and laboratory criteria are essential to identify the spectrum of disease associated with APS. We believe a set of criteria was developed that can precisely define affected family members with APS. Modeling studies utilizing these criteria strongly support a genetic basis for disease in families with APS and suggest that a susceptibility gene is inherited in an autosomal dominant pattern. However, in these families, APS was not linked with HLA, Fas, or other candidate genes, including beta2-glycoprotein 1, HLA, T cell receptor beta chain, Ig heavy chain, antithrombin III, Fas ligand, factor V, complement factor H, IgK, and Fas.  (+info)

Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. (4/26926)

To study the effect of continued telomere shortening on chromosome stability, we have analyzed the telomere length of two individual chromosomes (chromosomes 2 and 11) in fibroblasts derived from wild-type mice and from mice lacking the mouse telomerase RNA (mTER) gene using quantitative fluorescence in situ hybridization. Telomere length at both chromosomes decreased with increasing generations of mTER-/- mice. At the 6th mouse generation, this telomere shortening resulted in significantly shorter chromosome 2 telomeres than the average telomere length of all chromosomes. Interestingly, the most frequent fusions found in mTER-/- cells were homologous fusions involving chromosome 2. Immortal cultures derived from the primary mTER-/- cells showed a dramatic accumulation of fusions and translocations, revealing that continued growth in the absence of telomerase is a potent inducer of chromosomal instability. Chromosomes 2 and 11 were frequently involved in these abnormalities suggesting that, in the absence of telomerase, chromosomal instability is determined in part by chromosome-specific telomere length. At various points during the growth of the immortal mTER-/- cells, telomere length was stabilized in a chromosome-specific man-ner. This telomere-maintenance in the absence of telomerase could provide the basis for the ability of mTER-/- cells to grow indefinitely and form tumors.  (+info)

Plasmid replication initiator protein RepD increases the processivity of PcrA DNA helicase. (5/26926)

The replication initiator protein RepD encoded by the Staphylococcus chloramphenicol resistance plasmid pC221 stimulates the helicase activity of the Bacillus stearothermophilus PcrA DNA helicase in vitro. This stimulatory effect seems to be specific for PcrA and differs from the stimulatory effect of the Escherichia coli ribosomal protein L3. Whereas L3 stimulates the PcrA helicase activity by promoting co-operative PcrA binding onto its DNA substrate, RepD stimulates the PcrA helicase activity by increasing the processivity of the enzyme and enables PcrA to displace DNA from a nicked substrate. The implication of these results is that PcrA is the helicase recruited into the replisome by RepD during rolling circle replication of plasmids of the pT181 family.  (+info)

Transplacement mutagenesis: a novel in situ mutagenesis system using phage-plasmid recombination. (6/26926)

Site-specific mutagenesis provides the ability to alter DNA with precision so that the function of any given gene can be more fully understood. Several methods of in vitro mutagenesis are time-consuming and imprecise, requiring the subcloning and sequencing of products. Here we describe a rapid, high fidelity method of in situ mutagenesis in bacteriophage lambda using transplacement. Using this method, mutations are transferred from oligonucleotides to target phages using a plasmid interface. A small (50 bp) homology region bearing a centred point mutation is generated from oligonucleotides and subcloned into a transplacement plasmid bearing positive and negative phage selectable markers. Following a positive/negative selection cycle of integrative recombination and excision, the point mutation is transferred precisely from plasmid to phage in a subset ( approximately 25-50%) of recombinants. As the fidelity of both oligonucleotide synthesis and phage-plasmid recombination is great, this approach is extremely reliable. Using transplacement, point mutations can be accurately deposited within large phage clones and we demonstrate the utility of this technique in the construction of gene targeting vectors in bacteriophages.  (+info)

Rapid modification of bacterial artificial chromosomes by ET-recombination. (7/26926)

We present a method to modify bacterial artificial chromosomes (BACs) resident in their host strain. The method is based on homologous recombination by ET-cloning. We have successfully modified BACs at two distinct loci by recombination with a PCR product containing homology arms of 50 nt. The procedure we describe here is rapid, was found to work with high efficiency and should be applicable to any BAC modification desired.  (+info)

Amplification of cDNA ends based on template-switching effect and step-out PCR. (8/26926)

A new method for amplifying cDNA ends is described which requires only first-strand cDNA synthesis and a single PCR to generate a correct product with very low or no background. The method can be successfully applied to total RNA as well as poly A+ RNA. The same first-strand cDNA can be used to amplify flanking sequences of any cDNA species present in the sample.  (+info)

doi:10.1016/S0304-3975(00)00406-0. Schmitt, Lothar M. (2004). "Theory of Genetic Algorithms II: models for genetic operators ... Genetic programming List of genetic algorithm applications Genetic algorithms in signal processing (a.k.a. particle filters) ... These less fit solutions ensure genetic diversity within the genetic pool of the parents and therefore ensure the genetic ... Skiena advises against genetic algorithms for any task: [I]t is quite unnatural to model applications in terms of genetic ...
Thein, S. L.; Old, J. M.; Wainscoat, J. S.; Petrou, M.; Modell, B.; Weatherall, D. J. (1984-06-01). "Population and genetic ... The studies suggested that they are considerably hetero-genetic and have small genetic difference among them which is due to ... that this location may have been the origin of this genetic group. The genetic similarities between North Indians and Eastern ... They have some genetic commonalities as well as differences with other ethnic groups of India. According to a 2017 study by ...
a tutorial on genetic particle models Joachim De Zutter Craig Aaen Stockdale (June 1, 2008). "A (r)evolution in Crime-fighting ... a tutorial on genetic particle models Hitoshi Iba, Sumitaka Akiba, Tetsuya Higuchi, Taisuke Sato: BUGS: A Bug-Based Search ... "an article on genetic particle models". Archived from the original on 2012-05-01. Retrieved 2011-12-29. Hill T, Lundgren A, ... "a review article on genetic particle models". Archived from the original on 2012-05-01. Retrieved 2011-12-29. "Feynman-Kac ...
McMaster University website on genetic distance Computing distance by stepwise genetic distance model, web pages of Bruce Walsh ... This has happened because different authors considered different evolutionary models. The most commonly used are Nei's genetic ... It assumes that genetic differences arise due to genetic drift only. One major advantage of this measure is that the ... Genetic distance is a measure of the genetic divergence between species or between populations within a species, whether the ...
This is not a problem within mathematical models of genetic load, or for empirical studies that compare the relative value of ... Haag, C. R.; Roze, D. (2007). "Genetic load in sexual and asexual diploids: segregation, dominance and genetic drift". Genetics ... genetic load in one setting to genetic load in another. Deleterious mutation load is the main contributing factor to genetic ... have more surviving offspring than the average individual from a population with a high genetic load. Genetic load can also be ...
The gene's-eye view was a synthesis of the population genetic models of the modern synthesis, in particular the work of RA ... An important component of modeling these processes in natural populations is to consider the genetic response in the target ... Some selfish genetic elements manipulate the genetic transmission process to their own advantage, and so end up being ... First, sex and outcrossing put selfish genetic elements into new genetic lineages. In contrast, in a highly selfing or asexual ...
... and Illingworth infer that the Gaussian Model is a more accurate way to account for Genetic drift. The Moran model assumes ... One important alternative source of stochasticity, perhaps more important than genetic drift, is genetic draft. Genetic draft ... which claims that most of the genetic changes are caused by genetic drift acting on neutral mutations. The role of genetic ... Mathematical models of genetic drift can be designed using either branching processes or a diffusion equation describing ...
The primary model and test case of German editions has been Johann Wolfgang von Goethe while in England and the United States ... Completed works of genetic editing are known as genetic editions. These documents are similar to documentary editions but it ... Genetic editing is strong in European, particularly French and German, textual scholarship. The German genetic editing, which ... genetic editing closely examines a single extant manuscript and traces back each aspect to cast light on the work. Genetic ...
Taxonomy and Archetypes of Business Models in Direct-to-Consumer Genetic Testing". Journal of Medical Internet Research. 22 (1 ... Direct-to-consumer (DTC) genetic testing (also called at-home genetic testing) is a type of genetic test that is accessible ... Genetic testing is often done as part of a genetic consultation and as of mid-2008 there were more than 1,200 clinically ... Genetic testing can also include measuring the results of genetic changes, such as RNA analysis as an output of gene expression ...
Much depends on how "African" is defined and the model of interpretation. The various genetic studies usually suffer from what ... Genetic studies on Jews Genetic studies on Arabs Genetic history of the Iberian Peninsula Genetic studies on Moroccans Genetic ... Genetic genealogy, Human population genetics, Modern human genetic history, Indigenous peoples of North Africa, Genetic history ... The genetic history of North Africa encompasses the genetic history of the people of North Africa. The most important source of ...
Eshel, I.; Matessi, C. (August 1998). "Canalization, genetic assimilation and preadaptation. A quantitative genetic model". ... Crispo defines genetic assimilation as a kind of genetic accommodation, "evolution in response to both genetically based and ... Genetic assimilation is a process described by Conrad H. Waddington by which a phenotype originally produced in response to an ... Perturbations can be genetic or epigenetic rather than environmental. For example, Drosophila fruit flies have a heat shock ...
"Genetic demixing and evolution in linear stepping stone models". Reviews of Modern Physics. 82 (2): 1691-1718. arXiv:0904.4625 ... In biology, genetic demixing refers to a phenomenon in which an initial mixture of individuals with two or more distinct ... Population genetics Microbiology Genomics Ecology microbial ecology Genetic admixture Korolev, K. S.; Avlund, Mikkel; ...
However, different models may give different estimates of genetic variances. They found that expected genetic variances usually ... In this research, the researchers use the different relationship models to compare estimates of genetic variance components and ... 3. Genetic variance-covariance (G) matrices conveniently summarize the genetic relationships among a suite of traits and are a ... ISSN 0962-1083 Legarra, Andres (2016). "Comparing estimates of genetic variance across different relationship models". ...
Alcais A, Philippi A, Abel L (1999). "Genetic model-free linkage analysis using the maximum-likelihood- binomial method for ... Lathrop GM, Lalouel JM (1984). "Easy calculations of lod scores and genetic risks on small computers". Am J Hum Genet. 36 (2): ... Kong A, Cox NJ (1997). "Allele-sharing models: LOD scores and accurate linkage tests". Am J Hum Genet. 61 (5): 1179-1188. doi: ... Lange K, Papp JC, Sinsheimer JS, Sripracha R, Zhou H, Sobel EM (2013). "Mendel: the Swiss army knife of genetic analysis ...
Translation: Numerical optimization of computer models, Wiley, Chichester, 1981. ISBN 0-471-09988-0. OCLC 8011455. Wright, ... Mutation is a genetic operator used to maintain genetic diversity of the chromosomes of a population of a genetic or, more ... "Real-Coded Genetic Algorithms and Interval-Schemata", Foundations of Genetic Algorithms, Elsevier, vol. 2, pp. 187-202, doi: ... Alden H. (1991), Rawlins, Gregory J. E. (ed.), Genetic Algorithms for Real Parameter Optimization, Foundations of Genetic ...
... models were introduced into behavioral genetics in the 1970s-1980s. Genetic correlations have applications ... A genetic correlation of 0 implies that the genetic effects on one trait are independent of the other, while a correlation of 1 ... A genetic correlation between two traits will tend to produce phenotypic correlations - e.g. the genetic correlation between ... The bivariate genetic correlation can be generalized to inferring genetic latent variable factors across > 2 traits using ...
"Genetic Programming and Jominy Test Modeling". www.cs.bham.ac.uk. Retrieved 2018-05-20. Nichael L. Cramer "A Representation for ... Meta-genetic programming is the proposed meta-learning technique of evolving a genetic programming system using genetic ... "Genetic Programming". www.cs.bham.ac.uk. Retrieved 2018-05-19. "Genetic Programming and Data Structures: Genetic Programming + ... "Genetic Programming Theory and Practice". www.cs.bham.ac.uk. Retrieved 2018-05-20. "A Field Guide to Genetic Programming". www. ...
Helbing, Dirk (ed.). "Agent-Based Modeling". Social Self-Organization: 25-70. Holland, John H. (1992). "Genetic Algorithms". ... Agent-based models now complement traditional compartmental models, the usual type of epidemiological models. ABMs have been ... Building DREAM models allows model comparison across scientific disciplines. Validated agent-based modeling using Virtual ... but argued for the creation of a very large model that incorporates low level models. By modeling a complex system of analysts ...
"Projection regression models for multivariate imaging phenotype". Genetic Epidemiology. 36 (6): 631-641. doi:10.1002/gepi.21658 ... Vibration-based damage diagnosis in a laboratory cable-stayed bridge model via an RCP-ARX model based method (PDF). Proceedings ... Markon, Kristian E. (February 2010). "Modeling psychopathology structure: a symptom-level analysis of Axis I and II disorders ... Articles on Subsampling Romano, Joseph P.; Wolf, Michael (September 2001). "Subsampling intervals in autoregressive models with ...
Stender, J.; Hillebrand, E.; Kingdon, J. (1994). Genetic algorithms in optimisation, simulation, and modelling. Amsterdam: IOS ... Traditional genetic algorithms store genetic information in a chromosome represented by a bit array. Crossover methods for bit ... Mühlenbein, Heinz; Schlierkamp-Voosen, Dirk (1993). "Predictive Models for the Breeder Genetic Algorithm I. Continuous ... In genetic algorithms and evolutionary computation, crossover, also called recombination, is a genetic operator used to combine ...
ISBN 978-0-19-886229-1. Luo L, Zhang YM, Xu S (March 2005). "A quantitative genetics model for viability selection". Heredity. ... Higher genetic diversity and a larger population size will decrease the negative effects of genetic drift and inbreeding in a ... For long-term genetic viability, the population size should consist of enough breeding pairs to maintain genetic diversity. The ... The minimum viable population needed to maintain genetic viability is where the loss of genetic variation because of small ...
van Someren EP, Wessels LF, Backer E, Reinders MJ (July 2002). "Genetic network modeling". Pharmacogenomics. 3 (4): 507-525. ... Model refinement Cross-check how well the results meet the expectations. The process is terminated upon obtaining a good model ... Model selection A formalism to model your system, usually an ordinary differential equation, boolean network, or Linear ... There is great interest in network medicine for the modelling biological systems. This article focuses on inference of ...
"Alex Carneiro Interview". Genetic War. Retrieved 13 September 2015. "Learn the secret to dropping body fat from IFBB pro Alex ... "Fitness Model Alex Carneiro Talks with Sixpackfactory.com". Sicpackfactory.com. Retrieved 13 September 2015. "Alex Carnerio". ... "Interview With Physique Athlete and Pro-Fitness Model Alex Carneiro". ManiacFitness. Retrieved 13 September 2015. "Personal ... "IFBB Pro and Fitness Model Alex Carneiro Talks to Directlyfitness.com". DirectlyFitness. Retrieved 13 September 2015. " ...
This model was popularized by Ernst Mayr in his 1954 paper "Change of genetic environment and evolution," and his classic ... Their paper built upon Ernst Mayr's model of geographic speciation, I. M. Lerner's theories of developmental and genetic ... Lerner, I.M. (1954). Genetic Homeostasis. New York, NY: John Wiley. Eldredge, Niles (1971). "The allopatric model and phylogeny ... According to Michael Benton, "it seems clear then that stasis is common, and that had not been predicted from modern genetic ...
... is a computer program based on genetic algorithm that creates ecological niche models for species. The generated models ... Environmental niche modelling Stockwell, D. R. B. 1999. Genetic algorithms II. Pages 123-144 in A. H. Fielding, editor. Machine ... A GARP model is a random set of mathematical rules which can be read as limiting environmental conditions. Each rule is ... The GARP modelling system: Problems and solutions to automated spatial prediction. International Journal of Geographic ...
And as mentioned, since HR can lead to aggressive chromosomal rearrangement, loss of genetic information that could contribute ... A double-strand break repair model refers to the various models of pathways that cells undertake to repair double strand-breaks ... In terms of repair models in the cell cycle, HR is only possible during the S and G2 phases, while NHEJ can occur throughout ... Besides HR and NHEJ, there are also other repair models which exists in cells. Some are categorized under HR, such as synthesis ...
Eshel I, Matessi C (August 1998). "Canalization, genetic assimilation and preadaptation. A quantitative genetic model". ... It is, however, possible to explain genetic assimilation using only quantitative genetics and a threshold model, with no ... Genetic canalisation could allow for evolutionary capacitance, where genetic diversity accumulates in a population over time, ... thus buffering against genetic variation in those pathways. hsp83 mutants would therefore release the cryptic genetic variation ...
"Animal Models in Drug Discovery". Taconic Biosciences. Retrieved 2020-01-14. Herper M. "The Truly Staggering Cost Of Inventing ... Klotz L (16 January 2014). "What Is the Real Drug Development Cost for Very Small Biotech Companies?". Genetic Engineering & ... Only then do scientists work on developing chemical compounds to treat these abnormalities with the aid of computer models. ...
Committee on Animal Models for Research on Aging; National Research Council (U.S.). Committee on Animal Models for Research on ... "Peromycus maniculatus Deer Mouse , Peromyscus Genetic Stock Center , University of South Carolina". www.pgsc.cas.sc.edu. ... Crossland, J. & Lewandowski, A. (2006). "Peromyscus - A fascinating laboratory animal model" (PDF). Techtalk. 11 (1-2). ... Aging (1981). Mammalian models for research on aging. National Academies. ISBN 978-0-309-03094-6. Retrieved 11 May 2011. Dice, ...
... but researchers are attempting to clarify it by combining reliable genetic techniques, such as genetically-ablated model ... This model yields a structure which is more random at the tips than in the major lines, which is related to the fact that ... However, this model does not take into effect the diffusion of oxygen or signalling factors which may play a role in embryonic ... In this model, a traveling pressure wave would act upon the vasculature via shear stress to rearrange branches into the lowest- ...
ACCE, which takes its name from the four main criteria for evaluating a genetic test - analytic validity, clinical validity, ... testing for disorders with a genetic component in a format that allows policy makers to have access to up-to-date and reliable ... clinical utility and associated ethical, legal and social implications - is a model process that includes collecting, ... ACCE Model Process for Evaluating Genetic Tests including an introduction to ACCE, ACCE resources and references. It includes ...
Genetic Diversity among Clonal Lineages within Escherichia coli O157:H7 Stepwise Evolutionary Model Peter C.H. Feng*. , Steven ... Genetic Diversity among Clonal Lineages within Escherichia coli O157:H7 Stepwise Evolutionary Model. ...
... seven genetic mouse models have been reported to show increased lifespan: Ames and Snell dwarf mice, the little mouse (Ghrhr( ... Genetic mouse models of extended lifespan Exp Gerontol. 2003 Nov-Dec;38(11-12):1353-64. doi: 10.1016/j.exger.2003.10.019. ... Since 1996, seven genetic mouse models have been reported to show increased lifespan: Ames and Snell dwarf mice, the little ... While these seven genetic models all show a significant increase in lifespan, issues of sample size and animal husbandry ...
Maybe the genetic test report your doctor ordered says your DNA contains many ... Expert proposes new model to generate automated updates of genetic test results. *Download PDF Copy ... Tags: Bases, Bioinformatics, Children, Diagnostic, Diagnostics, DNA, Doctor, Exome Sequencing, Gene, Genes, Genetic, Genetic ... www.chop.edu/news/chop-expert-proposes-new-model-continuously-update-genetic-test-results ...
... in building genetic regulatory networks (GRN). Explore the regulatory mechanisms between genes and organism functions. Uncover ... Discover the power of Hidden Markov Models (HMM) ... The application of hidden markov model in building genetic ... Ji, R. , Liu, D. and Zhang, W. (2010) The application of hidden markov model in building genetic regulatory network. Journal of ... Hidde, D.J. (2002) Modeling and simulation of genetic regulatory systems: A literature review. Journal of Computational Biology ...
A widely unexplored field in humans, though clearly documented in rodents, is genetic brain inflammation, particularly that ... Immunization of Cnp −/− mice, a genetic model of mild primary white matter encephalitis, against NMDAR1. Young female Cnp−/− ... NMDAR1 autoantibodies amplify behavioral phenotypes of genetic white matter inflammation: a mild encephalitis model with ... NMDAR1 autoantibodies amplify behavioral phenotypes of genetic white matter inflammation: a mild encephalitis model with ...
... associated genes in the Drosophila model, which included seven genes that had never been analyzed in a pre-clinical model. " ... Next steps include using the in vivo models for drug screens in order to identify treatments for kidney diseases that currently ...
... has the potential to shape the distribution of genetic diversity and influence speciation. However, detecting and... ... availability of large genetic datasets thanks to the decreasing cost of genotyping and sequencing in both model and non-model ... to quantify the extent of local adaptation in Anatomically Modern Humans by using climate-informed spatial genetic models ( ... CISGeM) to reconstruct past population sizes, local movements, and range expansions, and thus provide a null model against ...
We applied biophysically detailed models of layer V pyramidal cells and sinoatrial node cells to study the contribution of ... effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling ...
A genetic timestamping mouse model has shown the rate at which antibody-producing cells accumulate and disappear after ... Genetic timestamping model reveals lifespan of cells behind vaccine-induced immunity. By Nick Paul Taylor, The Science Advisory ... October 31, 2022 -- A genetic timestamping mouse model has shown the rate at which antibody-producing cells accumulate and ... In the mouse model, the administration of a single vaccine dose triggered the production of around 40,000 persisting plasma ...
Using Java 3DTM-based computer models of targeted organisms (mouse, rat, and human) the team will develop four dimensional ( ... This project will create fully integrated virtual reality models of all aspects of disease. This will include medical ... as well as international genetic disease research. Their goal is to advance the field of genomics research in an easily ... spatial and temporal) approaches to data visualization, querying, and mining to help elucidate the nature of genetic disease. ...
The economics of genetic modified trees in forestry: Time to model and value?. Editorial article ... Karl-Gustaf Löfgren (2005), "The economics of genetic modified trees in forestry: Time to model and value?", Journal of Forest ...
Genetic and economic modelling comparing closed captive koala populations suggest that supplementing them with cryopreserved ... We present a modelled scenario, supported by detailed costings, where these technologies are optimized and could be integrated ... Ambitious genetic retention targets (maintaining 90%, 95% and 99% of source population heterozygosity for 100 years) could be ... Integrating biobanking into the zoo and wildlife hospital network presents a cost-effective and financially feasible model for ...
A fuzzy programming model and a genetic algorithm are developed to solve the proposed model with different sizes. The mining ... 4.3.4. Mathematical Model. The proposed biobjective model is formulated as follows:. st. ... A fuzzy credibility model is applied for the integrated proposed model. The credibility measure is defined as [33]. where and A ... A fuzzy programming model and a genetic algorithm are developed to solve the proposed model with different sizes. The mining ...
The economics of genetic modified trees in forestry: Time to model and value?. Editorial article ... Karl-Gustaf Löfgren (2005), "The economics of genetic modified trees in forestry: Time to model and value?", Journal of Forest ...
This regression model was compared to two null models: one in which neither a genetic variant nor open chromatin element affect ... To this end, we compared interacting models, found to represent 32.29% of significant intra-TAD models (Fig. 1C), with models ... Genetic variation within CTCF binding sites can alter binding potential41,42. We hypothesized that our regression models ... of SNPs are shared between non-additive interacting models and additive models, and 22.59% are shared with models that contain ...
Modeling Human Multimodal Perception and Control Using Genetic Maximum Likelihood Estimation. Title Modeling Human Multimodal ... The genetic maximum likelihood method is successfully applied to data from a recent human-in-the-loop experiment. Accurate ... This paper presents a new method for estimating the parameters of multi-channel pilot models that is based on maximum ... Perception and Control Using Genetic Maximum Likelihood Estimation. Author Zaal, P.M.T. Pool, D.M. Chu, Q.P. Van Paassen, M.M. ...
The researchers built a computational genetic model to predict the risk to the Israeli participants by determining a genetic ... Researchers at Tel Aviv University have developed a computational model that makes it possible to predict each womans genetic ... TAU Researchers Develop Computational Model to Predict Genetic Risk for Breast Cancer. By ... TAU Researchers Develop Computational Model to Predict Genetic Risk for Breast Cancer ...
Seminars and Events at the Research Institute of Molecular Pathology (IMP) and Vienna Biocenter (VBC).
250+ Modeling Agencies Worldwide. All Ages, Sizes, Heights Welcome. GET SCOUTED® ... ModelScouts.com Scouts Models for Genetic Model Management Los Angeles & ... Genetics diverse team holds experiences across the fashion & art industries, providing models and clients with outstanding and ... Genetic Models Management is a premier boutique agency located in Los Angeles, CA. ...
Title:Extending a Physics-Based Constitutive Model using Genetic Programming. Authors:Gabriel Kronberger, Evgeniya Kabliman, ... Download a PDF of the paper titled Extending a Physics-Based Constitutive Model using Genetic Programming, by Gabriel ... Download a PDF of the paper titled Extending a Physics-Based Constitutive Model using Genetic Programming, by Gabriel ... The approach is used to extend a physics-based constitutive model for deformation processes. This constitutive model operates ...
We contend that genetic factor analytic modeling provided a new approach to unravel the complexity of animal behaviors and FPSS ... Deciphering cattle temperament measures derived from a four-platform standing scale using genetic factor analytic modeling. ... This was followed by fitting a pedigree-based Bayesian multi-trait model to characterize the genetic interrelationships among ... Deciphering cattle temperament measures derived from a four-platform standing scale using genetic factor analytic modeling ...
Phenotypes & Models Find Models new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner ... If inbred animal models are used, then both the genetic constitution and environmental influences can be carefully controlled. ... Genetic analysis of susceptibility to endometrial adenocarcinoma in the BDII rat model.. ... Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 ...
... there is a need for upscaled models that do not requir ... Due to the considerable computational demands of modeling ... Upscaling models of solute transport in porous media through genetic programming David J. Hill; David J. Hill ... This study investigates the development of upscaled solute transport models using genetic programming (GP), a domain- ... Upscaling models of solute transport in porous media through genetic programming. Journal of Hydroinformatics 1 October 2007; 9 ...
... curd firming modeling, milk yield, composition, and acidity in Sarda dairy sheep ... Genetic analysis of coagulation properties, curd firming modeling, milk yield, composition, and acidity in Sarda dairy sheep. ... properties and curd-firming modeling parameters of ovine milk using Fourier-transform infrared spectroscopy and Bayesian models ... curd firmness modeling and acidity in milk from Brown Swiss cows Animal: An International Journal of Animal Bioscience 9(7): ...
Likelihood Ratio Test for Multi-Sample Mixture Model and Its Application to Genetic Imprinting. ... Likelihood Ratio Test for Multi-Sample Mixture Model and Its Application to Genetic Imprinting. ... Likelihood Ratio Test for Multi-Sample Mixture Model and Its Application to Genetic Imprinting. ... Likelihood Ratio Test for Multi-Sample Mixture Model and Its Application to Genetic Imprinting ...
Be it resolved that the genetic and fossil evidence supports the evolution model and refutes the biblical creation model.. ... Problem: the genetic distance between chimps and humans is the same as the genetic distance between the two most distantly ... He says "The genetic information for all finch beak shapes is built in and they can flip flop beak shape almost at will." ... The genetic information for all finch beak shapes is built in and they can flip flop beak shape almost at will. This is ...

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