An alcohol produced from mint oils or prepared synthetically.
Agents, usually topical, that relieve itching (pruritus).
A subgroup of TRP cation channels named after melastatin protein. They have the TRP domain but lack ANKYRIN repeats. Enzyme domains in the C-terminus leads to them being called chanzymes.
A plant genus of the family LAMIACEAE that is the source of peppermint oil.
Substances and products derived from NICOTIANA TABACUM.
Cellular receptors which mediate the sense of temperature. Thermoreceptors in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and NOCICEPTORS which detect cold or heat extreme enough to cause pain.
The sensation of cold, heat, coolness, and warmth as detected by THERMORECEPTORS.
Activity involved in transfer of goods from producer to consumer or in the exchange of services.
An absence of warmth or heat or a temperature notably below an accustomed norm.
Compounds with a core of 10 carbons generally formed via the mevalonate pathway from the combination of 3,3-dimethylallyl pyrophosphate and isopentenyl pyrophosphate. They are cyclized and oxidized in a variety of ways. Due to the low molecular weight many of them exist in the form of essential oils (OILS, VOLATILE).
Acrolein is an unsaturated aldehyde (C3H4O), highly reactive, toxic and naturally occurring compound that can be found in certain foods, tobacco smoke and is produced as a result of environmental pollution or industrial processes.
The aggregate business enterprise of agriculture, manufacture, and distribution related to tobacco and tobacco-derived products.
A phenol obtained from thyme oil or other volatile oils used as a stabilizer in pharmaceutical preparations, and as an antiseptic (antibacterial or antifungal) agent. It was formerly used as a vermifuge.
A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with SENSATION is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a DROSOPHILA mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. ANKYRIN repeats are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES.
Drugs that act locally on cutaneous or mucosal surfaces to produce inflammation; those that cause redness due to hyperemia are rubefacients; those that raise blisters are vesicants and those that penetrate sebaceous glands and cause abscesses are pustulants; tear gases and mustard gases are also irritants.
Sensation of enjoyment or gratification.
Systematic organization, storage, retrieval, and dissemination of specialized information, especially of a scientific or technical nature (From ALA Glossary of Library and Information Science, 1983). It often involves authenticating or validating information.

The posterior nasal nerve plays an important role on cardiopulmonary reflexes to nasal application of capsaicin, distilled water and l-menthol in anesthetized dogs. (1/240)

The sensory innervation of the cardiopulmonary reflexes to nasal application of capsaicin (CAPS), distilled water (DW) and l-menthol (LM) was studied in anesthetized dogs breathing through tracheostomy. A marked cardiopulmonary reflex was observed by CAPS and DW into the nasal cavity, while a prolongation of expiration was induced by LM. All these reflexes were significantly decreased by bilateral section of the posterior nasal nerve (PNN) and completely abolished by topical nasal anesthesia with lidocaine. Responses of the whole nerve activity of the PNN to these substances corresponded to the magnitude of the reflexes. These results indicate that PNN afferents play an important role on the reflex elicitation of the noxious, water and cold stimuli from the nasal cavity.  (+info)

Metabolism of (R)-(+)-pulegone and (R)-(+)-menthofuran by human liver cytochrome P-450s: evidence for formation of a furan epoxide. (2/240)

(R)-(+)-Pulegone, a monoterpene constituent of pennyroyal oil, is a hepatotoxin that has been used in folklore medicine as an abortifacient despite its potential lethal effects. Pulegone is metabolized by human liver cytochrome P-450s to menthofuran, a proximate hepatotoxic metabolite of pulegone. Expressed human liver cytochrome (CYP) P-450s (1A2, 2A6, 2C9, 2C19, 2D6, 2E1, and 3A4) were tested for their ability to catalyze the oxidations of pulegone and menthofuran. Expressed CYP2E1, CYP1A2, and CYP2C19 oxidized pulegone to menthofuran, with respective Km and Vmax values of 29 microM and 8.4 nmol/min/nmol P-450 for CYP2E1, 94 microM and 2.4 nmol/min/nmol P-450 for CYP1A2, and 31 microM and 1.5 nmol/min/nmol P-450 for CYP2C19. The human liver P-450s involved in the metabolism of menthofuran are the same as pulegone except for the addition of CYP2A6. These P-450s were found to oxidize menthofuran to a newly identified metabolite, 2-hydroxymenthofuran, which is an intermediate in the formation of the known metabolites mintlactone and isomintlactone. Based on studies with 18O2 and H218O, 2-hydroxymenthofuran arises predominantly from a dihydrodiol formed from a furan epoxide. CYP2E1, CYP1A2, and CYP2C19 oxidized menthofuran with respective Km and Vmax values of 33 microM and 0.43 nmol/min/nmol P-450 for CYP2E1, 57 microM and 0.29 nmol/min/nmol P-450 for CYP1A2, and 62 microM and 0.26 nmol/min/nmol P-450 for CYP2C19.  (+info)

Developmental regulation of monoterpene biosynthesis in the glandular trichomes of peppermint. (3/240)

Monoterpene production in peppermint (Mentha x piperita L.) glandular trichomes is determined by the rate of biosynthesis, as determined by (14)CO(2) incorporation, and is restricted to leaves 12 to 20 d of age. Using oil glands isolated from peppermint leaves of different ages, in vitro assay of the eight sequential enzymes responsible for the biosynthesis of the principal monoterpene (-)-menthol indicated that all but one biosynthetic enzyme had a very similar developmental profile. Activities were highest in leaves 12 to 20 d of age, with a sharp peak centered at 15 d. The exception, (-)-menthone reductase, the last enzyme of the pathway, exhibited a later peak of activity, which was centered at approximately 21 d. The correlation between in vitro enzyme activity and the rate of biosynthesis measured in vivo suggests that monoterpene formation is controlled mainly by the coordinately regulated activity of the relevant biosynthetic enzymes. Developmental immunoblotting of limonene synthase, which catalyzes the committed step of the pathway, demonstrated a direct correlation between enzyme activity and enzyme protein, suggesting that the dynamic time course for the remaining pathway enzyme activities also reflects the corresponding protein levels. RNA-blot analyses indicated that the genes encoding enzymes of the early pathway steps are transcriptionally activated in a coordinated fashion, with a time course superimpossible with activity measurements and immunoblot data. These results demonstrating coincidental temporal changes in enzyme activities, enzyme protein level, and steady-state transcript abundances indicate that most of the monoterpene biosynthetic enzymes in peppermint are developmentally regulated at the level of gene expression.  (+info)

Amplification of odor-induced Ca(2+) transients by store-operated Ca(2+) release and its role in olfactory signal transduction. (4/240)

A critical role of Ca(2+) in vertebrate olfactory receptor neurons (ORNs) is to couple odor-induced excitation to intracellular feedback pathways that are responsible for the regulation of the sensitivity of the sense of smell, but the role of intracellular Ca(2+) stores in this process remains unclear. Using confocal Ca(2+) imaging and perforated patch recording, we show that salamander ORNs contain a releasable pool of Ca(2+) that can be discharged at rest by the SERCA inhibitor thapsigargin and the ryanodine receptor agonist caffeine. The Ca(2+) stores are spatially restricted; emptying produces compartmentalized Ca(2+) release and capacitative-like Ca(2+) entry in the dendrite and soma but not in the cilia, the site of odor transduction. We deplete the stores to show that odor stimulation causes store-dependent Ca(2+) mobilization. This odor-induced Ca(2+) release does not seem to be necessary for generation of an immediate electrophysiological response, nor does it contribute significantly to the Ca(2+) transients in the olfactory cilia. Rather, it is important for amplifying the magnitude and duration of Ca(2+) transients in the dendrite and soma and is thus necessary for the spread of an odor-induced Ca(2+) wave from the cilia to the soma. We show that this amplification process depends on Ca(2+)-induced Ca(2+) release. The results indicate that stimulation of ORNs with odorants can produce Ca(2+) mobilization from intracellular stores without an immediate effect on the receptor potential. Odor-induced, store-dependent Ca(2+) mobilization may be part of a feedback pathway by which information is transferred from the distal dendrite of an ORN to its soma.  (+info)

'Microsmatic' primates revisited: olfactory sensitivity in the squirrel monkey. (5/240)

Using a conditioning paradigm, the olfactory sensitivity of three squirrel monkeys to nine odorants representing different chemical classes as well as members of a homologous series of substances was investigated. The animals significantly discriminated dilutions as low as 1:10,000 n-propionic acid, 1:30,000 n-butanoic acid and n-pentanoic acid, 1:100,000 n-hexanoic acid, 1:1Mio n-heptanoic acid, 1:30, 000 1-pentanol, 1:300,000 1,8-cineole, 1:1Mio n-heptanal and 1:30Mio amyl acetate from the near-odorless solvent, with single individuals scoring even slightly better. The results showed (i) the squirrel monkey to have an unexpectedly high olfactory sensitivity, which for some substances matches or even is better than that of species such as the rat or the dog, and (ii) a significant negative correlation between perceptibility in terms of olfactory detection thresholds and carbon chain length of carboxylic acids. These findings support the assumptions that olfaction may play a significant and hitherto underestimated role in the regulation of primate behavior, and that the concept of primates as primarily visual and 'microsmatic' animals needs to be revised.  (+info)

Purification and characterization of a Baeyer-Villiger mono-oxygenase from Rhodococcus erythropolis DCL14 involved in three different monocyclic monoterpene degradation pathways. (6/240)

A Baeyer-Villiger mono-oxygenase (BVMO), catalysing the NADPH- and oxygen-dependent oxidation of the monocyclic monoterpene ketones 1-hydroxy-2-oxolimonene, dihydrocarvone and menthone, was purified to homogeneity from Rhodococcus erythropolis DCL14. Monocyclic monoterpene ketone mono-oxygenase (MMKMO) is a monomeric enzyme of molecular mass 60 kDa. It contains 1 mol of FAD/monomer as the prosthetic group. The N-terminal amino acid sequence showed homology with many other NADPH-dependent and FAD-containing (Type 1) BVMOs. Maximal enzyme activity was measured at pH 9 and 35 degrees C. MMKMO has a broad substrate specificity, catalysing the lactonization of a large number of monocyclic monoterpene ketones and substituted cyclohexanones. The natural substrates 1-hydroxy-2-oxolimonene, dihydrocarvone and menthone were converted stoichiometrically into 3-isopropenyl-6-oxoheptanoate (the spontaneous rearrangement product of the lactone formed by MMKMO), 4-isopropenyl-7-methyl-2-oxo-oxepanone and 7-isopropyl-4-methyl-2-oxo-oxepanone respectively. The MMKMO-catalysed conversion of iso-dihydrocarvone showed an opposite regioselectivity to that of dihydrocarvone; in this case, 6-isopropenyl-3-methyl-2-oxo-oxepanone was formed as the product. MMKMO converted all enantiomers of the natural substrates with almost equal efficiency. MMKMO is involved in the conversion of the monocyclic monoterpene ketone intermediates formed in the degradation pathways of all stereoisomers of three different monocyclic monoterpenes, i.e. limonene, (dihydro)carveol and menthol.  (+info)

Role of C-5 chiral center in R-(+)-pulegone-mediated hepatotoxicity: metabolic disposition and toxicity of 5, 5-dimethyl-2-(1-Methylethylidene)-cyclohexanone in rats. (7/240)

Metabolic disposition of 5, 5-dimethyl-2-(1-methylethylidene)-cyclohexanone (I) was examined in rats. Compound (I) was administered orally (250 mg/kg of body weight/day) to rats for 5 days. The following urinary metabolites were isolated and identified: 4,5,6,7-tetrahydro-3,6, 6-trimethylbenzofuran (III), 3,3-dimethylcyclohexanone (VI), 5, 5-dimethyl-3-hydroxy-2-(1-methylethylidene)-cyclohexanone (X), 5, 5-dimethyl-2-(1-hydroxymethylethyl)-cyclohexanone (IX), 3-hydroxy-5-hydroxymethyl-5-methyl-2-(1-methylethylidene)-cyclo hexano ne (XI), 5,6-dihydro-3,6,6-trimethyl-2(4H)-benzofuranone (VIII), and 5,5-dimethyl-3-hydroxy-2-(1-carboxy ethylidene)-cyclohexanone (XIII). Incubation of compound (I) with phenobarbital (PB)-induced rat liver microsomes in the presence of NADPH resulted in the formation of a metabolite, tentatively identified as a furanoterpene (III) based on proton magnetic resonance, gas chromatography, and gas chromatography-mass spectroscopy analyses. The formation of III was inhibited to a significant extent by carbon monoxide, metyrapone, SKF 525-A, and cytochrome c, suggesting the participation of PB-induced microsomal cytochrome P-450 system in the conversion of I to III. Compound I gave type I spectral change in the PB-induced liver microsomes and the dissociation constant (Ks) for I was 38.5 microM. Intraperitoneal administration of a single dose (250 mg/kg) of I to rats resulted in 26, 23, and 41% decreases in the levels of cytochrome P-450, glucose-6-phosphatase, and aminopyrine N-demethylase, respectively, at the end of 24 h. During this period, a 11-fold increase in serum glutamate pyruvate transaminase level was also observed. However, a decrease in the level of cytochrome P-450 and glucose-6-phosphatase, and an increase in serum glutamate pyruvate transaminase values were comparatively more pronounced when R-(+)-pulegone (250 mg/kg) or CCl(4) (0.6 ml/kg) was administered to rats. Pretreatment of rats with PB potentiated the hepatotoxicity caused by I, whereas pretreatment with 3-methylcholanthrene protected from it. This suggests that PB-induced cytochrome P-450-catalyzed reactive metabolites may be responsible for the toxic effects caused by I.  (+info)

Inhibition of plant asparagine synthetase by monoterpene cineoles. (8/240)

Asparagine (Asn) synthetase (AS) is the key enzyme in Asn biosynthesis and plays an important role in nitrogen mobilization. Despite its important physiological function, little research has been done documenting inhibitors of plant AS. Plant growth inhibition caused by the natural monoterpene 1,4-cineole and its structurally related herbicide cinmethylin was reversed 65% and 55%, respectively, by providing 100 microM Asn exogenously. Reversion of the phytotoxic effect was dependent on the concentration of Asn. The presence of either 1,4-cineole or cinmethylin stimulated root uptake of [(14)C]Asn by lettuce (Lactuca sativa) seedlings. Although the physiological responses suggested that both compounds affected Asn biosynthesis, biochemical analysis of AS activity showed that the natural monoterpene was a potent inhibitor (I(50) = approximately 0. 5 microM) of the enzyme, whereas the commercial product was not inhibitory up to levels of 10 mM. Analysis of the putative metabolite, 2-hydroxy-1,4-cineole, showed that the cis-enantiomer was much more active than the trans-enantiomer, suggesting that the hydroxyl group was involved in the specific ligand/active site interaction. This is the first report that AS is a suitable herbicide target site, and that cinmethylin is apparently a proherbicide that requires metabolic bioactivation via cleavage of the benzyl-ether side chain.  (+info)

Menthol is a compound obtained from the crystals of the mint plant (Mentha arvensis). It is a white, crystalline substance that is solid at room temperature but becomes a clear, colorless, oily liquid when heated. Menthol has a cooling and soothing effect on mucous membranes, which makes it a common ingredient in over-the-counter products used to relieve symptoms of congestion, coughs, and sore throats. It is also used as a topical analgesic for its pain-relieving properties and as a flavoring agent in various products such as toothpaste, mouthwashes, and candies.

Antipruritics are a class of medications or substances that are used to relieve or prevent itching (pruritus). They work by reducing the sensation of itchiness and can be applied topically to the skin, taken orally, or administered intravenously. Some common antipruritics include diphenhydramine, hydroxyzine, and corticosteroids.

Transient Receptor Potential Melastatin (TRPM) cation channels are a subfamily of the transient receptor potential (TRP) channel superfamily, which are non-selective cation channels that play important roles in various cellular processes such as sensory perception, cell proliferation, and migration.

The TRPM subfamily consists of eight members (TRPM1-8), each with distinct functional properties and expression patterns. These channels are permeable to both monovalent and divalent cations, including calcium (Ca^2+^) and magnesium (Mg^2+^).

TRPM channels can be activated by a variety of stimuli, such as changes in temperature, voltage, osmolarity, and chemical ligands. For example, TRPM8 is known to be activated by cold temperatures and menthol, while TRPV1 is activated by heat and capsaicin.

Dysregulation of TRPM channels has been implicated in various pathological conditions, including pain, neurodegenerative diseases, and cancer. Therefore, understanding the structure and function of these channels may provide insights into potential therapeutic targets for these conditions.

"Mentha piperita" is the scientific name for peppermint, which is a hybrid plant that's a cross between watermint and spearmint. It is a commonly used herb in medicine, particularly in the form of peppermint oil. The oil has been found to have several medicinal properties including antimicrobial, analgesic, anti-inflammatory, and antispasmodic effects. It is often used to treat gastrointestinal disorders such as irritable bowel syndrome (IBS), nausea, and vomiting. Additionally, it has been found to be effective in providing relief from headaches and muscle pain.

Tobacco products are defined as any items that contain tobacco, including but not limited to cigarettes, cigars, pipe tobacco, snuff, chewing tobacco, and electronic nicotine delivery systems (such as e-cigarettes). These products can be smoked, smokeless, or heated and involve the inhalation or ingestion of tobacco or its derivatives. They are known to cause addiction due to their nicotine content and can lead to a variety of serious health problems, including cancer, heart disease, and lung disease.

Thermoreceptors are specialized sensory nerve endings or neurons that are sensitive to changes in temperature. They detect and respond to heat or cold stimuli by converting them into electrical signals that are transmitted to the brain for interpretation. These receptors are found throughout the body, particularly in the skin, mucous membranes, and internal organs. There are two main types of thermoreceptors: warm receptors, which respond to increasing temperatures, and cold receptors, which react to decreasing temperatures. The information provided by thermoreceptors helps maintain homeostasis and protect the body from harmful temperature changes.

Thermosensing refers to the ability of living organisms to detect and respond to changes in temperature. This is achieved through specialized proteins called thermosensors, which are capable of converting thermal energy into chemical or electrical signals that can be interpreted by the organism's nervous system. Thermosensing plays a critical role in regulating various physiological processes, such as body temperature, metabolism, and development. In medicine, understanding thermosensing mechanisms can provide insights into the treatment of conditions associated with impaired temperature regulation, such as fever or hypothermia.

I am not aware of a specific medical definition for the term "marketing." In general, marketing refers to the activities involved in promoting, selling, and distributing a product or service. This can include market research, product development, advertising, public relations, sales, and customer service. Marketing is used in many industries, including healthcare, to connect with and engage customers, build brand awareness, and increase sales.

"Cold temperature" is a relative term and its definition can vary depending on the context. In general, it refers to temperatures that are lower than those normally experienced or preferred by humans and other warm-blooded animals. In a medical context, cold temperature is often defined as an environmental temperature that is below 16°C (60.8°F).

Exposure to cold temperatures can have various physiological effects on the human body, such as vasoconstriction of blood vessels near the skin surface, increased heart rate and metabolic rate, and shivering, which helps to generate heat and maintain body temperature. Prolonged exposure to extreme cold temperatures can lead to hypothermia, a potentially life-threatening condition characterized by a drop in core body temperature below 35°C (95°F).

It's worth noting that some people may have different sensitivities to cold temperatures due to factors such as age, health status, and certain medical conditions. For example, older adults, young children, and individuals with circulatory or neurological disorders may be more susceptible to the effects of cold temperatures.

Monoterpenes are a class of terpenes that consist of two isoprene units and have the molecular formula C10H16. They are major components of many essential oils found in plants, giving them their characteristic fragrances and flavors. Monoterpenes can be further classified into various subgroups based on their structural features, such as acyclic (e.g., myrcene), monocyclic (e.g., limonene), and bicyclic (e.g., pinene) compounds. In the medical field, monoterpenes have been studied for their potential therapeutic properties, including anti-inflammatory, antimicrobial, and anticancer activities. However, more research is needed to fully understand their mechanisms of action and clinical applications.

Acrolein is an unsaturated aldehyde with the chemical formula CH2CHCHO. It is a colorless liquid that has a distinct unpleasant odor and is highly reactive. Acrolein is produced by the partial oxidation of certain organic compounds, such as glycerol and fatty acids, and it is also found in small amounts in some foods, such as coffee and bread.

Acrolein is a potent irritant to the eyes, nose, and throat, and exposure to high levels can cause coughing, wheezing, and shortness of breath. It has been shown to have toxic effects on the lungs, heart, and nervous system, and prolonged exposure has been linked to an increased risk of cancer.

In the medical field, acrolein is sometimes used as a laboratory reagent or as a preservative for biological specimens. However, due to its potential health hazards, it must be handled with care and appropriate safety precautions should be taken when working with this compound.

A Tobacco Industry is a commercial sector involved in the cultivation, production, manufacturing, marketing, and distribution of tobacco and tobacco-related products. This can include growers who produce tobacco leaves, manufacturers who process the leaves into various forms (such as cigarettes, chewing tobacco, or snuff), and companies that market and distribute these products to consumers. It is important to note that the tobacco industry has been associated with significant health risks, as the use of tobacco products can lead to a range of serious health problems, including cancer, heart disease, and lung disease.

Thymol is not a medical condition or term, but rather it's an organic compound that is commonly used in the medical and pharmaceutical fields. Thymol is a natural monoterpene phenol derivative of cymene, found in oil of thyme and other essential oils. It has antiseptic, antibiotic, and antifungal properties, which makes it useful as a disinfectant and preservative in various medical and dental applications.

In some contexts, thymol may be used to treat conditions related to fungal or bacterial infections, but it is not typically used as a standalone treatment. Instead, it's often combined with other active ingredients in medications such as mouthwashes, throat lozenges, and topical creams.

It's important to note that thymol should be used under the guidance of a healthcare professional, as its misuse or overuse can lead to adverse effects.

Transient receptor potential (TRP) channels are a type of ion channel proteins that are widely expressed in various tissues and cells, including the sensory neurons, epithelial cells, and immune cells. They are named after the transient receptor potential mutant flies, which have defects in light-induced electrical responses due to mutations in TRP channels.

TRP channels are polymodal signal integrators that can be activated by a diverse range of physical and chemical stimuli, such as temperature, pressure, touch, osmolarity, pH, and various endogenous and exogenous ligands. Once activated, TRP channels allow the flow of cations, including calcium (Ca2+), sodium (Na+), and magnesium (Mg2+) ions, across the cell membrane.

TRP channels play critical roles in various physiological processes, such as sensory perception, neurotransmission, muscle contraction, cell proliferation, differentiation, migration, and apoptosis. Dysfunction of TRP channels has been implicated in a variety of pathological conditions, including pain, inflammation, neurodegenerative diseases, cardiovascular diseases, metabolic disorders, and cancer.

There are six subfamilies of TRP channels, based on their sequence homology and functional properties: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPP (polycystin), and TRPML (mucolipin). Each subfamily contains several members with distinct activation mechanisms, ion selectivity, and tissue distribution.

In summary, Transient Receptor Potential Channels are a group of polymodal cation channels that play critical roles in various physiological processes and are implicated in many pathological conditions.

Irritants, in a medical context, refer to substances or factors that cause irritation or inflammation when they come into contact with bodily tissues. These substances can cause a range of reactions depending on the type and duration of exposure, as well as individual sensitivity. Common examples include chemicals found in household products, pollutants, allergens, and environmental factors like extreme temperatures or friction.

When irritants come into contact with the skin, eyes, respiratory system, or mucous membranes, they can cause symptoms such as redness, swelling, itching, pain, coughing, sneezing, or difficulty breathing. In some cases, prolonged exposure to irritants can lead to more serious health problems, including chronic inflammation, tissue damage, and disease.

It's important to note that irritants are different from allergens, which trigger an immune response in sensitive individuals. While both can cause similar symptoms, the underlying mechanisms are different: allergens cause a specific immune reaction, while irritants directly affect the affected tissues without involving the immune system.

I'm sorry for any confusion, but "pleasure" is not typically defined in medical terms. It is more commonly understood in psychological or philosophical contexts. Pleasure is often described as a positive emotional response associated with satisfying needs and desires, or enjoying certain experiences. However, in a medical context, the term might be used to describe the positive feelings some people may associate with certain health-related behaviors or experiences. For example, a person might derive pleasure from engaging in regular exercise, which can have positive effects on their physical and mental health.

In a medical context, documentation refers to the process of recording and maintaining written or electronic records of a patient's health status, medical history, treatment plans, medications, and other relevant information. The purpose of medical documentation is to provide clear and accurate communication among healthcare providers, to support clinical decision-making, to ensure continuity of care, to meet legal and regulatory requirements, and to facilitate research and quality improvement initiatives.

Medical documentation typically includes various types of records such as:

1. Patient's demographic information, including name, date of birth, gender, and contact details.
2. Medical history, including past illnesses, surgeries, allergies, and family medical history.
3. Physical examination findings, laboratory and diagnostic test results, and diagnoses.
4. Treatment plans, including medications, therapies, procedures, and follow-up care.
5. Progress notes, which document the patient's response to treatment and any changes in their condition over time.
6. Consultation notes, which record communication between healthcare providers regarding a patient's care.
7. Discharge summaries, which provide an overview of the patient's hospital stay, including diagnoses, treatments, and follow-up plans.

Medical documentation must be clear, concise, accurate, and timely, and it should adhere to legal and ethical standards. Healthcare providers are responsible for maintaining the confidentiality of patients' medical records and ensuring that they are accessible only to authorized personnel.

The main form of menthol occurring in nature is (−)-menthol, which is assigned the (1R,2S,5R) configuration. Menthol has local ... Menthol also acts as a weak κ-opioid receptor agonist. Natural menthol exists as one pure stereoisomer, nearly always the (1R, ... Menthol also shares anaesthetic properties similar to propofol by modulating the same sites of the GABAA receptor. Menthol is ... "Menthol". Drug Information Portal. U.S. National Library of Medicine. Ryoji Noyori Nobel lecture (2001) A review of menthol ...
... menthol content by weight. Lower-tar menthol cigarettes may have menthol levels up to 2%, in order to keep menthol delivery ... A menthol cigarette is a cigarette infused with the compound menthol which imparts a "minty" flavor to the smoke. Menthol also ... Menthol cigarettes are just as hard to quit and are just as harmful as regular cigarettes. Menthol cigarettes have been banned ... Menthol may be derived from distilled corn mint oil, or produced synthetically. While trace amounts of menthol may be added to ...
In enzymology, a (−)-menthol monooxygenase (EC 1.14.13.46) is an enzyme that catalyzes the chemical reaction (−)-menthol + ... This enzyme is also called l-menthol monooxygenase. Use of (−)-menthol monooxygenase has been explored by several companies ... The systematic name of this enzyme class is (−)-menthol,NADPH:oxygen oxidoreductase (8-hydroxylating). ... menthol, NADPH, H+, and O2, whereas its 3 products are p-menthane-3,8-diol, NADP+, and H2O. This enzyme belongs to the family ...
A (−)-menthol dehydrogenase (EC 1.1.1.207) is an enzyme that catalyzes the chemical reaction (−)-menthol + NADP+ ⇌ {\ ... Kjonaas R, Martinkus-Taylor C, Croteau R (May 1982). "Metabolism of Monoterpenes: Conversion of l-Menthone to l-Menthol and d- ... Thus, the two substrates of this enzyme are (−)-menthol and NADP+, whereas its 3 products are (−)-menthone, NADPH, and H+. This ... The systematic name of this enzyme class is (−)-menthol:NADP+ oxidoreductase. This enzyme is also called monoterpenoid ...
Menthol - A Cool Place -Page 1 (Articles with short description, Short description is different from Wikidata, Chemical data ... Baker MSDS (l-form) Fisher MSDS (DL or racemic form) Fisher MSDS (l-form) Ambix MSDS Menthol Eucalyptus ointment This box: view ... This page provides supplementary chemical data on Menthol. The handling of this chemical may incur notable safety precautions. ...
... is a 1994 EP by Guided by Voices. The song Matter Eater Lad is based on the superhero ... www.allmusic.com/album/clown-prince-of-the-menthol-trailer-ep-mw0000927549 "GBVDB - Guided By Voices Database". www.gbvdb.com. ... a 2022 compilation collecting many of these tracks Clown Prince of the Menthol Trailer,http:// ...
Davis EM, Ringer KL, McConkey M, Croteay R (2005). "Enzyme Menthol deghydrogenase". Matthijs HC, Coughlan SJ, Hind G (September ...
"Hotel Menthol musical". Cervinus Teatrum. Retrieved 2020-07-25. Hungária Zene.hu Discogs (CS1 Hungarian-language sources (hu), ... The 1981 album Hotel Menthol was another substantial hit. In 1982 the band played to 150,000 people at Népstadion in Budapest. ... Koncert a marson (1970) Hungária (1971) Beatles Laz (1978) Rock 'n' Roll Party (1980) Hotel Menthol (1981) Arena (1983) Finale ... titled Hotel Menthol, debuted in 1998 and was performed more than 200 times. ...
"Djarum Forte Menthol". CiggiesWorld. Retrieved 2022-02-17. "Djarum Super". CiggiesWorld. Retrieved 2022-02-17. "Djarum Super ...
"Cooler Than Menthol". Retrieved 2008-06-14. v t e (Chemical articles with multiple compound IDs, Multiple chemicals in an ... While the cooling strength of 3-(l-menthoxy)propane-1,2-diol is accepted as being about 20-25% that of menthol, it is also ... Menthoxypropanediol (also known as Cooling agent 10 [tradename of Takasago]), is a synthetic derivative of menthol. ... 2-diol shows a cool feeling 2.0 to 2.5 times stronger than that of l-menthol". It is used in various cosmetic chemical ...
Halls contain menthol, which acts as local anaesthetic and "creates a cooling sensation". It also acts as a cough suppressant. ... "Halls Cough Drops (Menthol)". Iodine, Medication information that really helps. Retrieved 25 April 2016. "HALLS MENTHO-LYPTUS ( ...
"Pianissimo Pêche Menthol One". Chen1923.blogspot.nl. 17 August 2008. Retrieved 1 February 2018. v t e (Articles with short ... "Pianissimo Pêche Menthol One". Chen1923.blogspot.nl. 17 August 2008. "PIANISSIMO - Okcig.com". Archived from the original on ... other variants like Petil and Franc were added and other JT Menthol brands were made into Pianissimo. Like Virginia S made by ...
"Tobacco makers fight menthol rules". Associated Press. 18 March 2011. Archived from the original on 27 April 2012. Retrieved 27 ... In March 2011, the tobacco industry released a report to the FDA in response to the TPSAC decision claiming menthol cigarettes ... Wilson, Duff (18 March 2011). "Advisory Panel Urges F.D.A. to Re-examine Menthol in Cigarettes". New York Times. Retrieved 27 ... On March 18, 2011 the panel concluded that removing menthol cigarettes from the market would benefit public health in the ...
In addition, mints can desensitize a region through the activation of TRPM8 receptors (the 'cold'/menthol receptor). The key ... Galeotti N, Di Cesare Mannelli L, Mazzanti G, Bartolini A, Ghelardini C (April 2002). "Menthol: a natural analgesic compound". ... biased agonist Erinacine E Menthol RB-64 - G protein biased agonist with a bias factor of 96; β-arrestin antagonist Salvinorin ... the naturally-occurring compound menthol is a weak KOR agonist owing to its antinociceptive, or pain blocking, effects in rats ...
"HORIZON LINES/BEL-AIR MENTHOL , LACMA Collections". collections.lacma.org. Retrieved 2023-08-05. Desmarais, Ilene Segalove: Why ... Gifts/I Love You/Bel Air Menthol (1975), and If You Live Near Hollywood, You Can't Help But Look Like Some 8x10 Glossy (1976). ...
The active ingredient is menthol and it also contains cetylated and esterified fatty acids. A before/after human study with no ... "Celadrin joint and muscle pain relieving- menthol cream". DailyMed. U.S. National Library of Medicine. Retrieved 2020-07-28. ... May 2005). "A cetylated fatty acid topical cream with menthol reduces pain and improves functional performance in individuals ... Factors Group of Nutritional Products (January 2013). "Prescribing monograph for Celadrin (menthol)". DailyMed. U.S. National ...
In most essential oils, it is a minor compound; it was first synthesized by oxidation of menthol in 1881 before it was found in ... On menthol or peppermint camphor". Journal of the Chemical Society, Transactions. 39: 77-83. doi:10.1039/CT8813900077. John ... It is structurally related to menthol, which has a secondary alcohol in place of the carbonyl. Menthone is used in flavoring, ... It was then synthesized by heating menthol with chromic acid, and its structure was later confirmed by synthesizing it from 2- ...
Gaubius isolated menthol in 1771. He was elected a Fellow of the Royal Society in 1764. One of his best known works was ...
Menthol - Adds sweet smell 3. Borneol - for smelling, relieves dizziness; for fainting, relieves pain and ache 4. Paraffin - ...
Menthol activates cold-sensitive TRPM8 receptors in the skin and mucosal tissues, and is the primary source of the cooling ... R. Eccles (1994). "Menthol and Related Cooling Compounds". J. Pharm. Pharmacol. 46 (8): 618-630. doi:10.1111/j.2042-7158.1994. ... M. × piperita and M. haplocalyx are both recognized as plant sources of menthol and menthone, and are among the oldest herbs ... Peppermint has a high menthol content. The essential oil also contains menthone and carboxyl esters, particularly menthyl ...
... excluding menthol); removed descriptions including "light," "mild," and "low-tar" from cigarette packs; and made larger the ...
In the same year, with the bans of menthol cigarettes in Nova Scotia in June 2015 and Alberta in September 2015, Global Tobacco ... In 2015, the Canadian Cancer Society warned that the use of so-called "click" cigarettes (which contain a capsule of menthol in ... Benham, Barbara (20 July 2016). "Menthol-Like Cigarettes Still Sold in Canada Despite Ban". Johns Hopkins Bloomberg School of ... Canadian Classics Original Canadian Classics Silver Canadian Classics White Canadian Classics Crush (menthol capsule) Canadian ...
Non-menthol throat lozenges generally use either zinc gluconate glycine or pectin as an oral demulcent. Several brands of ... However, one study found that excessive use of menthol cough drops can prolong coughs rather than relieve them. Candies to ... Other varieties such as Halls contain menthol, peppermint oil and/or spearmint as their active ingredient(s). Honey lozenges ... "Menthol Cough Drops: Cause for Concern?". Journal of the American Board of Family Medicine. 31 (2): 183-191. doi:10.3122/jabfm. ...
Measurable levels of eucalyptol and pulegone were found in the menthol-flavored varieties for all manufacturers. Menthol ... Interestingly, menthol was found at low concentrations in 40% of the tobacco-flavored nonmenthol products tested. Other flavor ... Menthol flavorings could also contain diacetyl. Diacetyl and acetyl propionyl are associated with bronchiolitis obliterans. A ... The four most commonly found flavor additives were vanillin, ethyl maltol, ethyl vanillin and menthol. They are carcinogenic or ...
The active ingredient of Original Strength Gold Bond Powder is Menthol. Inactive ingredients include talc and zinc oxide. The ... "Gold Bond Original Strength- menthol powder". DailyMed. National Institutes of Health. January 15, 2016. Archived from the ...
Menthol Pulegone BSBI List 2007 (xls). Botanical Society of Britain and Ireland. Archived from the original (xls) on 2015-06-26 ...
Menthol appeals to younger or beginning smokers largely because the menthol masks the harshness and discomfort of inhaling ... Trying menthols increases smoking initiation among youth and young adults, and menthols users face greater addiction and ... Where these demographics overlap, menthol use is especially high: most female LGBT smokers use menthols, as do 80 percent of ... excluding menthol. Canada banned menthol cigarettes in 2017. Preliminary research in Ontario Province indicates that this ban ...
"Débile menthol" was the first single released from the album on 26 April 2006. "Débile menthol - Single by Elisa Tovati". ...
Kaplan, Sheila (March 22, 2021). "Menthol Cigarettes Kill Many Black People. A Ban May Finally Be Near". New York Times. ...
"EU agrees ban on menthol cigarettes". RTÉ.ie. 21 June 2013. Archived from the original on 21 February 2014. Retrieved 6 ...
The main form of menthol occurring in nature is (−)-menthol, which is assigned the (1R,2S,5R) configuration. Menthol has local ... Menthol also acts as a weak κ-opioid receptor agonist. Natural menthol exists as one pure stereoisomer, nearly always the (1R, ... Menthol also shares anaesthetic properties similar to propofol by modulating the same sites of the GABAA receptor. Menthol is ... "Menthol". Drug Information Portal. U.S. National Library of Medicine. Ryoji Noyori Nobel lecture (2001) A review of menthol ...
Prohibiting sales of menthol and other tobacco products.. *Raising the price of menthol and other tobacco products and ... Learn about menthol and its relationship to tobacco product use and nicotine dependence among young people, how menthol ... Menthol Tobacco Productsplus icon*Menthol Tobacco Products are a Public Health Problem ... For example, after laws prohibiting the sale of menthol cigarettes were implemented in Canada, adults who smoked menthol ...
This article discusses menthol poisoning from swallowing pure menthol. ... This article discusses menthol poisoning from swallowing pure menthol. ... Menthol is used to add peppermint flavor to candy and other products. It is also used in certain skin lotions and ointments. ... Menthol is used to add peppermint flavor to candy and other products. It is also used in certain skin lotions and ointments. ...
About 80 percent of black smokers prefer menthol cigarettes compared with 22 percent of white smokers. The civil rights group ... Food and Drug Administration is debating a ban on menthol cigarettes as their slightly minty taste can cover up tobaccos ... Should Menthol Cigarettes Be Banned? The U.S. Food and Drug Administration is debating a ban on menthol cigarettes as their ... And if 80 percent of smokers who are African-American use menthol products, to ban those products and to leave the non-menthol ...
No Menthol Sunday. No Menthol Sunday, an annual observance led by the Center for Black Health & Equity, is an opportunity to ... What Is Menthol?. Menthol is a chemical compound found naturally in peppermint and similar plants. It can also be produced in a ... Menthol Use. Targeted marketing of menthol cigarettes and other factors have contributed to tobacco-related health disparities ... And people who smoke menthol cigarettes may have more difficulty quitting smoking than people who smoke non-menthol cigarettes ...
CHERRY COUGH DROP- menthol lozenge BestCo Inc.. Disclaimer: Most OTC drugs are not reviewed and approved by FDA, however they ...
Are Menthol Smokers Different? An Economic Perspective Yu-Chun Cheng, Donald S. Kenkel, Alan D. Mathios & Hua Wang ... Of the 45.7 million current smokers in the U.S. age 12 and over, more than 18.5 million usually smoke menthol cigarettes. The ... We discuss several lines of evidence about whether self-selection into menthol use might be mainly quasi-random. We leave it to ... We acknowledge that the associations we document in observational data might reflect bias due to self-selection into menthol ...
Menthol is a white crystalline compound found in all mints, giving the green herbs their refreshing and aromatic properties. ... Menthol was used in Japan 2000 years before being known in the rest of the world. It is still a very popular ingredient today, ... Lush purchase menthol crystals from two sources in India. They extract the crystals from wild mint (Mentha arvensis). ... Menthol is a white crystalline compound found in all mints, giving the green herbs their refreshing and aromatic properties. ...
Ingrédients : Calcium carbonate, Bentonite, Xylitol Maltodextrin**, Sodium coco-sulfate, Citric acid, Xanthan gum, Menthol* ...
Find patient medical information for menthol topical on WebMD including its uses, side effects and safety, interactions, ... Menthol 5 % Topical Patch - Uses, Side Effects, and More Generic Name(S): menthol. ... How to use Menthol 5 % Topical Patch. Use this medication on the skin only. Clean and dry the affected area. Remove the backing ... Before using this product, tell your doctor or pharmacist if you are allergic to menthol; or if you have any other allergies. ...
Menthol not only gives smokers a "more pleasant" feeling in their mouths and throats, but also keeps tobacco smoke - with its ... The fact that menthol is added without the products label informing customers that it makes them more addictive is an ... Menthol additives, in fact, induce young people to start smoking, experts say. She tried smoking-cessation courses and holding ... The Florida case inspired Hausner to launch the first menthol-cigarette lawsuit in the world. ...
Menthol and mint tobacco products like vapes and mass-produced cigars have been shown to significantly increase youth tobacco ... After years without a response to the 2013 citizen petition that sought out a menthol cigarette ban, a lawsuit was filed by ... More than a third of cigarette purchases in the U.S. are for menthols, the largest proportion of sales, according to the ... The share of smokers who use menthols has risen continuously, from 30.5% in 2005 to 40.2% in 2019, according to data from the ...
Menthol milestone, the anniversary no one is celebrating. March 21, 2019. Menthol has been the tobacco industrys recruitment ... The smoothness of menthol allows smokers to inhale more deeply, so harmful particles can settle lower in the lungs. Menthol ... What does menthol have to do with it? Everything! Tobacco and.... March 2, 2017. ... The city of Chicago made history when it passed tobacco control legislation in mid-December that will regulate where menthol ...
The FDA is expected to announce a federal menthol cigarette ban, which would impact government revenue with likely limited ... Revenue Impact of Federal Menthol Cigarette Ban. State. Menthol cigarettes share of market. Excise tax rate per pack of 20 ... In Europe, where the menthol consumer group was much smaller, about 8 percent of menthol consumers reported quitting after the ... Federal Menthol Cigarette Ban May Cost Governments $6.6 Billion. March 2, 2022. November 20, 2023. 8 min readBy: Ulrik Boesen ...
The FDA estimates that eliminating menthol products would reduce smoking rates by 15% within 40 years. ... The FDA said menthol interacts with nicotine in the brain to enhance nicotines addictive effects. The combination of menthols ... Menthol accounts for more than a third of cigarettes sold in the U.S, and the mint flavor is overwhelmingly favored by Black ... Menthol is the only cigarette flavor that was not banned under the 2009 law that gave the FDA authority over tobacco products. ...
After finding that a ban on menthol cigarettes in Canada was linked to a large increase in the number of smokers who quit, ... Menthol smokers who had quit smoking before the menthol ban were also significantly less likely than non-menthol smokers who ... The researchers found that menthol smokers were much more likely than non-menthol smokers to try to quit after the menthol ban ... and that daily menthol smokers were nearly two times more likely than daily non-menthol smokers to quit after the menthol ban ...
MENTHOL (UNII: L7T10EIP3A) (MENTHOL - UNII:L7T10EIP3A) MENTHOL. 0.42 mg in 1 mL. ... ANTISEPTIC- eucalyptol, menthol, methyl salicylate, thymol mouthwash. Number of versions: 7. Published Date (What is this?). ... ANTISEPTIC- eucalyptol, menthol, methyl salicylate, thymol mouthwash. To receive this label RSS feed. Copy the URL below and ... eucalyptol 0.092 % / menthol 0.042 % / methyl salicylate 0.06 % / thymol 0.064 % Mouthwash. PSN. 2. 1043619. eucalyptol 0.92 MG ...
... and individuals reporting a greater frequency of mental distress are more likely to smoke menthol versus nonmenthol cigarettes ... Menthol cigarette smoking and health, Florida 2007 BRFSS Am J Health Behav. 2011 Jan-Feb;35(1):3-14. doi: 10.5993/ajhb.35.1.1. ... Objective: To examine associations between menthol cigarette smoking and nicotine dependence, quit attempts, and physical and ... Results: In multivariate analyses, menthol cigarette smoking was associated with women, African American and Hispanic race/ ...
... and menthol topical is a combination product that is applied to the skin. . When applied to the chest, inhaling the vapors of ... camphor, eucalyptus, and menthol topical camphor, eucalyptus, and menthol topical. Pronunciation: KAM for, ue ka LIP tus, and ... How should I use camphor, eucalyptus, and menthol topical? How should I use camphor, eucalyptus, and menthol topical?. Use ... What is camphor, eucalyptus, and menthol topical? What is camphor, eucalyptus, and menthol topical?. Camphor, eucalyptus, and ...
... supports arguments for enhanced regulation of tobacco marketing and tobacco ingredients such as menthol. ... and also in menthol smokers (aOR = 4.58, 95% CI = 1.94-10.78). Most smokers in this study (56%), and especially menthol smokers ... Smokers have varying misperceptions about the harmfulness of menthol cigarettes: national survey data Aust N Z J Public Health ... Objective: To describe the prevalence of menthol use and perceptions of relative harmfulness among smokers in an ethnically ...
Menthol cigarettes are just as hazardous, and some research has even suggested that menthol can actually magnify nicotines ... in part because advertisers focus on marketing menthols to them. Eighty-five percent of all Black smokers use menthol ... But if menthol cigarettes are your current go-to, you might want to consider quitting before they become hard to come by. ... Now, as CNN reports, the U.S. Food and Drug Administration (FDA) wants to do away with both menthol cigarettes and cigars of ...
Menthol-labelled cigarettes accounted for almost one-third of the US cigarette market in 2012.1 Menthol may be present in ... The amount of menthol measured in the whole cigarettes ranged from 2.9 to 19.6 mg/cigarette for menthol-flavoured cigarettes ... Instead of examining the menthol levels of different cigarette brands,5 we consider … ... 5 In an effort to understand how menthol may be used by various cigarette manufacturers, here we present the repeated and ...
As a result, nearly 9 out of 10 of African Americans that smoke, smoke menthols.The International Convention on the Eliminat... ...
Looking for a bit of a cool refreshing flavor while enjoying your tobacco. You are sure to find a favorite from the wide variety of brands below.
714-X is made by mixing chemicals with camphor, a natural substance that comes from the wood and bark of the camphor tree. 714-X is reported to help the ...
Menthol Architects Tower for Swifts is an 8-meter-high free-standing structure that provides birds with a safe place to nest ... One thought on "Menthol Architects Tower for Swifts Provides a Safe Nesting Place for Birds in Warsaw, Poland" * ... Menthol Architects Tower for Swifts Provides a Safe Nesting Place for Birds in Warsaw, Poland Architecture. ... Menthol Architects Tower for Swifts Provides a Safe Nesting Place for Birds in Warsaw, Poland. ...
The menthol cigarette citizens petition recalls the lost political tradition of petition democracy, when not only could the ... The menthol cigarette citizens petition recalls the lost political tradition of petition democracy, when not only could the ... The anti-menthol "citizens petition" was first sent to the FDA in 2013, after gathering support from a multiracial alliance ... The anti-menthol petition is neither a lawsuit nor an agonistic tantrum. It is a public document: accessible, readable, and ...
Detailed description for our premium quality Organic Menthol Crystals. We offer an impressive range of certified organic and ... Our Menthol Crystals are soluble in both oil and alcohol. Menthol Crystals are typically used at 5-20% in balms, liniments, ... Organic Menthol Crystals. Add to Personalized Shopping List. Save 25% on Select Sizes! Limited time only. Sorry, no rainchecks. ... INCI: Menthol. Typical Shelf Life*: 2 Years. *Typical Shelf Life begins on the date of manufacture and is defined as the ...
Cushmans Menthol Inhaler Description. Advertisement for Cushmans Menthol Inhaler depicting a young woman dressed with a ... Cushmans Menthol Inhaler . 1870-1890. Advertising Collection. LL02.12.01.38.02. East Carolina University Digital Collections. ... My husband Joe found a metal cap showing Cushmans menthol inhaler, Three Rivers, Mich. while metal detecting on our property. ... feather topped hat, holding a Cushmans Menthol Inhaler in her hand. The caption above the picture states: Catarrh, Neuralgia ...
My colleagues and I have introduced two bills that would significantly restrict menthol and flavored e-cigarettes in New York. ... Menthol smokers also become more addicted; they have a lower rate of quitting. Sadly, but not surprisingly, more than half of ... In addition to the menthol loophole, we also now have a new front in the war against flavored tobacco: e-cigarettes. It seems I ... My grandfather was a menthol smoker-as are many people of color. Eighty-five percent of Black adult smokers and 64 percent of ...

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