The three membranes that cover the BRAIN and the SPINAL CORD. They are the dura mater, the arachnoid, and the pia mater.
A delicate membrane enveloping the brain and spinal cord. It lies between the PIA MATER and the DURA MATER. It is separated from the pia mater by the subarachnoid cavity which is filled with CEREBROSPINAL FLUID.
Inflammation of the coverings of the brain and/or spinal cord, which consist of the PIA MATER; ARACHNOID; and DURA MATER. Infections (viral, bacterial, and fungal) are the most common causes of this condition, but subarachnoid hemorrhage (HEMORRHAGES, SUBARACHNOID), chemical irritation (chemical MENINGITIS), granulomatous conditions, neoplastic conditions (CARCINOMATOUS MENINGITIS), and other inflammatory conditions may produce this syndrome. (From Joynt, Clinical Neurology, 1994, Ch24, p6)
Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord.
The outermost of the three MENINGES, a fibrous membrane of connective tissue that covers the brain and the spinal cord.
A superfamily of nematodes of the order STRONGYLIDA. Characteristics include a fluid-filled outer layer of cuticle and a reduced mouth and bursa.
A villous structure of tangled masses of BLOOD VESSELS contained within the third, lateral, and fourth ventricles of the BRAIN. It regulates part of the production and composition of CEREBROSPINAL FLUID.
A species of the genus MACACA which inhabits Malaya, Sumatra, and Borneo. It is one of the most arboreal species of Macaca. The tail is short and untwisted.
A genus of parasitic nematodes of the superfamily METASTRONGYLOIDEA. Two species, ANGIOSTRONGYLUS CANTONENSIS and A. vasorum, infest the lungs of rats and dogs, respectively. A. cantonensis is transmissible to man where it causes frequently fatal infection of the central nervous system.
Irrigation of the nose with saline or irrigation solutions for diagnostic or therapeutic purposes. It is used to remove irritants, allergens, or microorganisms from the nose.
Neoplasms composed of fibrous tissue, the ordinary connective tissue of the body, made up largely of yellow or white fibers. The concept does not refer to neoplasms located in fibrous tissue.
A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)
An inflammatory process involving the brain (ENCEPHALITIS) and meninges (MENINGITIS), most often produced by pathogenic organisms which invade the central nervous system, and occasionally by toxins, autoimmune disorders, and other conditions.
Primary or secondary neoplasm in the ARACHNOID or SUBARACHNOID SPACE. It appears as a diffuse fibrotic thickening of the MENINGES associated with variable degrees of inflammation.
A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.

Ultramicroscopic structures of the leptomeninx of mice with communicating hydrocephalus induced by human recombinant transforming growth factor-beta 1. (1/402)

An experimental model of communicating hydrocephalus was developed based on intrathecal injection of human recombinant transforming growth factor-beta 1 (hrTGF-beta 1) in the mouse. To clarify the mechanism of this hydrocephalus model, the ultrastructure of the leptomeninx in the process of ventricular dilation was examined in C57/BL6 mice injected intrathecally with 60 ng of hrTGF-beta 1. The leptomeninx was examined at various periods after injection by light and electron microscopy. Immunostaining for fibroblasts and macrophages was also performed. Leptomeninx within a week after injection showed that the thin cytoplasmic processes of leptomeningeal cells formed a laminated structure with a meshwork, which was almost the same as the controls. In the second week, many cells with a round nucleus appeared in the leptomeninx. Immunohistochemically, these cells were positive for anti-fibroblast antibody and negative for anti-Mac-1 and anti-macrophage BM-8 antibodies. Three weeks later, the laminated structure was disrupted and abundant deposition of collagen fibers was found in the inter-cellular space of the leptomeninx. Such inter-meningeal fibrosis would disturb cerebrospinal fluid flow in the mouse leptomeninx and cause slowly progressive ventricular dilation.  (+info)

Transthyretin Leu12Pro is associated with systemic, neuropathic and leptomeningeal amyloidosis. (2/402)

We report a middle-aged woman with a novel transthyretin (TTR) variant, Leu12Pro. She had extensive amyloid deposition in the leptomeninges and liver as well as the involvement of the heart and peripheral nervous system which characterizes familial amyloid polyneuropathy caused by variant TTR. Clinical features attributed to her leptomeningeal amyloid included radiculopathy, central hypoventilation, recurrent subarachnoid haemorrhage, depression, seizures and periods of decreased consciousness. MRI showed a marked enhancement throughout her meninges and ependyma, and TTR amyloid deposition was confirmed by meningeal biopsy. The simultaneous presence of extensive visceral amyloid and clinically significant deposits affecting both the peripheral and central nervous system extends the spectrum of amyloid-related disease associated with TTR mutations. The unusual association of severe peripheral neuropathy with symptoms of leptomeningeal amyloid indicates that leptomeningeal amyloidosis should be considered part of the syndrome of TTR-related familial amyloid polyneuropathy.  (+info)

Meningioangiomatosis. A comprehensive analysis of clinical and laboratory features. (3/402)

Meningioangiomatosis (MA) is a rare, benign, focal lesion of the leptomeninges and underlying cerebral cortex characterized by leptomeningeal and meningovascular proliferation. It may occur sporadically or in association with neurofibromatosis type 2. Previous reports have emphasized histological and imaging features. Data on the management of these patients are sparse, and electrophysiological features of MA lesions have not been published. We assessed the clinical, electrophysiological, histopathological and imaging features as well as the surgical outcome in MA, and compared MA with and without neurofibromatosis. Seven patients with MA at our centre were investigated and their outcome was assessed. A review of the literature is included. MA exhibits a wide range of clinical, imaging, histopathological and electrophysiological features, making the diagnosis difficult. Sporadic MA cases are not associated with neurofibromatosis and the two disorders are genetically distinct. Medically refractory, localization-related epilepsy is the commonest presentation in sporadic cases, but atypical presentations also occur. Unlike sporadic cases, MA with neurofibromatosis is often found incidentally, does not produce seizures, occurs less frequently (ratio of 1:4), and is multifocal. MRI findings in MA correspond to the histological picture. However, the appearance on imaging is non-specific and may suggest cystic atrophy, angioma and tumours. Several abnormalities have been found in close proximity to MA lesions, i.e. meningioma, oligodendroglioma, arteriovenous malformation, encephalocoel and orbital erosion. In spite of histopathological diversity, MA lesions are either predominantly cellular or vascular. Immunohistochemical results are inconsistent among cases, add little to the diagnosis, and do not support a meningeal origin. Electrocorticographic recordings from the surface and within MA lesions revealed a spectrum of electrophysiological expressions. Intrinsic epileptogenicity of MA lesions was documented in some cases. Epileptogenicity was confined to the perilesional cortex in some patients and it was complex (extralesional, multifocal, generalized) in others. Only 43% of our patients became seizure-free postoperatively compared with 68% previously reported, and >70% of our patients and those in the literature continued to require antiepileptic drugs. This is in keeping with the diverse electrophysiology of MA and suggests a less optimistic postoperative outcome than previously recognized.  (+info)

Tumor necrosis factor alpha is a determinant of pathogenesis and disease progression in mycobacterial infection in the central nervous system. (4/402)

The pathogenesis of tuberculous meningitis, a devastating complication of tuberculosis in man, is poorly understood. We previously reported that rabbits with experimental tuberculous meningitis were protected from death by a combination of antibiotics and thalidomide therapy. Survival was associated with inhibition of tumor necrosis factor alpha (TNF-alpha) production by thalidomide. To test whether cerebrospinal fluid (CSF) levels of TNF-alpha correlated with pathogenesis, the response of rabbits infected in the central nervous system (CNS) with various mycobacterial strains was studied. CNS infection with Mycobacterium bovis Ravenel, M. bovis bacillus Calmette-Guerin (BCG) Pasteur, and M. bovis BCG Montreal were compared. M. bovis Ravenel induced the highest levels of TNF-alpha in the CSF in association with high leukocytosis, protein accumulation, and severe meningeal inflammation. BCG Pasteur had intermediate effects, and BCG Montreal was the least virulent. In addition, M. bovis Ravenel numbers were highest in the brain and CSF and the bacilli also disseminated more efficiently to distant organs, compared with BCG Pasteur and BCG Montreal. In subsequent experiments, rabbits were infected with either recombinant M. bovis BCG Montreal (vector), or BCG Montreal expressing the murine gene for TNF-alpha (BCG mTNF-alpha). BCG Montreal was rendered virulent by the expression of murine TNF-alpha, as demonstrated by high CSF leukocytosis, high protein accumulation, severe meningeal inflammation, persistent bacillary load, and progressive clinical deterioration. Taken together, these results demonstrate that the level of TNF-alpha produced during mycobacterial CNS infection determines, at least in part, the extent of pathogenesis.  (+info)

MR of CNS sarcoidosis: correlation of imaging features to clinical symptoms and response to treatment. (5/402)

BACKGROUND AND PURPOSE: Sarcoidosis is an idiopathic systemic granulomatous disease, recognized in a patient when clinical and radiologic findings are confirmed by histopathologic analysis. The objective was to identify a relationship between MR imaging and clinical findings in CNS sarcoidosis. METHODS: The clinical charts of 461 patients with biopsy-proved sarcoidosis were reviewed retrospectively. Criteria for including patients in the study included those with symptoms referable to the CNS, excluding those with another explanation for their symptoms, those with headaches or other subjective complaints without accompanying objective findings, and those with peripheral neuropathy other than cranial nerve involvement or myopathy without CNS manifestations. Thirty-four of 38 patients whose conditions met the criteria for CNS sarcoidosis underwent a total of 82 MR examinations. The positive imaging findings were divided into categories as follows: pachymeningeal, leptomeningeal, nonenhancing brain parenchymal, enhancing brain parenchymal, cranial nerve, and spinal cord and nerve root involvement. Treatment response, clinical symptomatology, and any available histopathologic studies were analyzed with respect to imaging manifestations in each of the categories. RESULTS: Eighty-two percent of the patients with sarcoidosis with neurologic symptoms referable to the CNS had findings revealed by MR imaging. However, eight (40%) of 20 cranial nerve deficits seen at clinical examination of 13 patients were not seen at contrast-enhanced MR imaging, and 50% of the patients with symptoms referable to the pituitary axis had no abnormal findings on routine contrast-enhanced MR images. In contradistinction, 44% of 18 cranial nerves in nine patients with MR evidence of involvement had no symptoms referable to the involved cranial nerve. Clinical and radiologic deterioration occurred more commonly with leptomeningeal and enhancing brain parenchymal lesions. CONCLUSION: MR imaging can be used to confirm clinical suspicion and to show subclinical disease and the response of pathologic lesions to treatment.  (+info)

Multifocal meningioangiomatosis: a report of two cases. (6/402)

We report the CT and MR findings in two patients with multifocal meningioangiomatosis, neither of whom had a family history or stigmata of neurofibromatosis. All lesions were located in the cortical and subcortical areas and had round dense calcifications with eccentric cysts. The masses were associated with surrounding edema and gliosis.  (+info)

Magnetization transfer MR imaging in CNS tuberculosis. (7/402)

BACKGROUND AND PURPOSE: CNS tuberculosis may simulate other granulomas and meningitis on MR images. The purpose of this study was to improve the characterization of lesions in CNS tuberculosis and to assess the disease load using magnetization transfer (MT) imaging. METHODS: A total of 107 tuberculomas in seven patients with or without meningitis and 15 patients with tuberculosis meningitis alone were studied. Fifteen patients with cysticercus granulomas with T2 hypointensity, five patients each with viral and pyogenic meningitis, and two patients with cryptococcal meningitis were also studied. The MT ratios were calculated from tuberculomas, cysticercus granulomas, and thickened meninges in tuberculous, viral, pyogenic, and cryptococcal meningitis and were compared within each pathologic group and with the MT ratio of different regions of normal brain parenchyma. Detectability of lesions on T1-weighted MT spin-echo (SE) images was compared with that on conventional SE and postcontrast MT-SE images. RESULTS: Thickened meninges appeared hyperintense relative to surrounding brain parenchyma in the basal and supratentorial cisterns on precontrast MT-SE images in all 18 patients with tuberculosis meningitis. These meninges were not seen or were barely visible on conventional SE images, and enhanced on postcontrast MT-SE images. The MT ratio from the thickened meninges of tuberculous meningitis was significantly lower than that from the meninges in cryptococcal and pyogenic disease and significantly higher than the meninges in viral meningoencephalitis. The MT ratio from T2 visible and invisible tuberculomas appeared to be significantly lower than that of normal white matter. The MT ratio of T2 hypointense cysticercus granuloma was significantly higher than that of T2 hypointense tuberculoma. CONCLUSION: Precontrast MT-SE imaging helps to better assess the disease load in CNS tuberculosis by improving the detectability of the lesions. With the use of MT ratios, it may be possible to differentiate tuberculosis from similar-appearing infective lesions on MR images.  (+info)

Sclerosing spinal pachymeningitis. A complication of intrathecal administration of Depo-Medrol for multiple sclerosis. (8/402)

Reported complications of intrathecal steroid therapy include aseptic meningitis, infectious meningitis, and arachnoiditis. We report a case of sclerosing spinal pachymeningitis complicating the attempted intrathecal administration of Depo-Medrol for multiple sclerosis. The lesion is characterised by concentric laminar proliferation of neomembranes within the subdural space of the entire spinal cord and cauda equina, resulting from repeated episodes of injury and repair to the spinal dura mater by Depo-Medrol. There is clinical and laboratory evidence that Depo-Medrol produces meningeal irritation and that the vehicle is the necrotising fraction.  (+info)

The meninges are the protective membranes that cover the brain and spinal cord. They consist of three layers: the dura mater (the outermost, toughest layer), the arachnoid mater (middle layer), and the pia mater (the innermost, delicate layer). These membranes provide protection and support to the central nervous system, and contain blood vessels that supply nutrients and remove waste products. Inflammation or infection of the meninges is called meningitis, which can be a serious medical condition requiring prompt treatment.

The arachnoid is one of the three membranes that cover the brain and the spinal cord, known as the meninges. It is located between the dura mater (the outermost layer) and the pia mater (the innermost layer). The arachnoid is a thin, delicate membrane that is filled with cerebrospinal fluid, which provides protection and nutrition to the central nervous system.

The arachnoid has a spider-web like appearance, hence its name, and it is composed of several layers of collagen fibers and elastic tissue. It is highly vascularized, meaning that it contains many blood vessels, and it plays an important role in regulating the flow of cerebrospinal fluid around the brain and spinal cord.

In some cases, the arachnoid can become inflamed or irritated, leading to a condition called arachnoiditis. This can cause a range of symptoms, including pain, muscle weakness, and sensory changes, and it may require medical treatment to manage.

Meningitis is a medical condition characterized by the inflammation of the meninges, which are the membranes that cover the brain and spinal cord. This inflammation can be caused by various infectious agents, such as bacteria, viruses, fungi, or parasites, or by non-infectious causes like autoimmune diseases, cancer, or certain medications.

The symptoms of meningitis may include fever, headache, stiff neck, nausea, vomiting, confusion, and sensitivity to light. In severe cases, it can lead to seizures, coma, or even death if not treated promptly and effectively. Bacterial meningitis is usually more severe and requires immediate medical attention, while viral meningitis is often less severe and may resolve on its own without specific treatment.

It's important to note that meningitis can be a serious and life-threatening condition, so if you suspect that you or someone else has symptoms of meningitis, you should seek medical attention immediately.

Meningeal neoplasms, also known as malignant meningitis or leptomeningeal carcinomatosis, refer to cancerous tumors that originate in the meninges, which are the membranes covering the brain and spinal cord. These tumors can arise primarily from the meningeal cells themselves, although they more commonly result from the spread (metastasis) of cancer cells from other parts of the body, such as breast, lung, or melanoma.

Meningeal neoplasms can cause a variety of symptoms, including headaches, nausea and vomiting, mental status changes, seizures, and focal neurological deficits. Diagnosis typically involves imaging studies (such as MRI) and analysis of cerebrospinal fluid obtained through a spinal tap. Treatment options may include radiation therapy, chemotherapy, or surgery, depending on the type and extent of the tumor. The prognosis for patients with meningeal neoplasms is generally poor, with a median survival time of several months to a year.

Dura Mater is the thickest and outermost of the three membranes (meninges) that cover the brain and spinal cord. It provides protection and support to these delicate structures. The other two layers are called the Arachnoid Mater and the Pia Mater, which are thinner and more delicate than the Dura Mater. Together, these three layers form a protective barrier around the central nervous system.

Metastrongyloidea is a superfamily of nematode (roundworm) parasites that have complex life cycles involving intermediate hosts such as mollusks or arthropods. The adult worms typically reside in the respiratory system, lungs, or other tissues of various mammalian hosts, including humans.

The Metastrongyloidea superfamily includes several medically and veterinarily important genera such as:

* Metastrongylus (e.g., M. pudendotectus, M. salmi) - found in the lungs of suids (pigs, wild boars, warthogs)
* Angiostrongylus (e.g., A. cantonensis, A. costaricensis) - parasites of rodents and other mammals, with zoonotic potential
* Crenosoma (e.g., C. vulpis, C. striatum) - found in the respiratory tracts of canids (dogs, wolves, foxes) and mustelids (otters, weasels)
* Varestrongylus (e.g., V. capreoli, V. alces) - parasites of cervids (deer, elk, moose)

These nematodes are often associated with respiratory and pulmonary diseases in their respective hosts, causing conditions such as pneumonia, bronchitis, or granulomatous inflammation. In humans, angiostrongyliasis can lead to eosinophilic meningitis, a severe neurological condition caused by the migration of larvae through the central nervous system.

The choroid plexus is a network of blood vessels and tissue located within each ventricle (fluid-filled space) of the brain. It plays a crucial role in the production of cerebrospinal fluid (CSF), which provides protection and nourishment to the brain and spinal cord.

The choroid plexus consists of modified ependymal cells, called plexus epithelial cells, that line the ventricular walls. These cells have finger-like projections called villi, which increase their surface area for efficient CSF production. The blood vessels within the choroid plexus transport nutrients, ions, and water to these epithelial cells, where they are actively secreted into the ventricles to form CSF.

In addition to its role in CSF production, the choroid plexus also acts as a barrier between the blood and the central nervous system (CNS), regulating the exchange of substances between them. This barrier function is primarily attributed to tight junctions present between the epithelial cells, which limit the paracellular movement of molecules.

Abnormalities in the choroid plexus can lead to various neurological conditions, such as hydrocephalus (excessive accumulation of CSF) or certain types of brain tumors.

"Macaca nemestrina," also known as the pig-tailed macaque, is not a medical term but a species name in biology. It refers to a specific species of monkey that is native to Southeast Asia. The pig-tailed macaque is a medium-sized monkey with a reddish-brown fur and a distinctive tail that resembles a pig's tail. They are omnivorous and live in social groups that can range from a few individuals to several hundred.

While "Macaca nemestrina" may not have a direct medical definition, these monkeys have been used as models in biomedical research due to their close genetic relationship with humans. Some studies involving pig-tailed macaques have contributed to our understanding of various human diseases and conditions, such as infectious diseases, neurological disorders, and reproductive health. However, it is important to note that the use of animals in research remains a controversial topic, and ethical considerations must be taken into account when conducting such studies.

Angiostrongylus is a genus of parasitic nematode roundworms that are known to cause serious diseases in humans and animals. The most common species that affects humans is Angiostrongylus cantonensis, also known as the rat lungworm. This parasite primarily infects rats but can accidentally infect humans through the consumption of raw or undercooked intermediate hosts, such as snails, slugs, or freshwater shrimp.

Infection with Angiostrongylus cantonensis can lead to a condition called angiostrongyliasis, which primarily affects the central nervous system. Symptoms of this disease may include severe headaches, neck stiffness, nausea, vomiting, and in some cases, temporary paralysis or long-term neurological damage.

Preventing Angiostrongylus infection involves avoiding the consumption of raw or undercooked intermediate hosts and practicing good hygiene when handling raw produce. In areas where the parasite is endemic, public health education campaigns are often implemented to raise awareness about the risks associated with this infection and promote preventative measures.

Nasal lavage, also known as nasal washing or saline irrigation, is a procedure in which a saline solution is used to flush out the nasal passages. This is often done to help relieve symptoms associated with nasal congestion, allergies, sinusitis, and other respiratory conditions. The process involves instilling the saline solution into one nostril and allowing it to flow out through the other, taking with it any mucus, debris, or irritants that may be present in the nasal passages. This can help promote better breathing, reduce inflammation, and alleviate symptoms such as sinus pressure, headaches, and sneezing. Nasal lavage can be performed using a variety of devices, including bulb syringes, neti pots, or specialized squeeze bottles designed specifically for this purpose.

Neoplasms of fibrous tissue are abnormal growths or tumors that originate from fibroblasts, the cells responsible for producing connective tissue in the body. These neoplasms can be benign or malignant (cancerous). Benign fibrous neoplasms include fibromas and fibrohistiocytic tumors, while malignant fibrous neoplasms are called fibrosarcomas. Fibrosarcomas are aggressive tumors that invade surrounding tissues and can metastasize (spread) to other parts of the body.

Fibrous tissue neoplasms can occur in any part of the body, but they are most commonly found in the soft tissues such as muscles, tendons, and ligaments. They can also develop in bones, where they are called osteosarcomas. Symptoms of fibrous tissue neoplasms depend on their size and location, but may include a painless mass or swelling, limited mobility, or pain if the tumor is pressing on nerves or blood vessels.

Diagnosis of fibrous tissue neoplasms typically involves imaging tests such as X-rays, CT scans, or MRI scans, followed by a biopsy to confirm the type and grade of the tumor. Treatment options may include surgery, radiation therapy, chemotherapy, or a combination of these approaches. Regular follow-up care is important to monitor for recurrence or metastasis.

A meningioma is a type of slow-growing tumor that forms on the membranes (meninges) surrounding the brain and spinal cord. It's usually benign, meaning it doesn't spread to other parts of the body, but it can still cause serious problems if it grows and presses on nearby tissues.

Meningiomas most commonly occur in adults, and are more common in women than men. They can cause various symptoms depending on their location and size, including headaches, seizures, vision or hearing problems, memory loss, and changes in personality or behavior. In some cases, they may not cause any symptoms at all and are discovered only during imaging tests for other conditions.

Treatment options for meningiomas include monitoring with regular imaging scans, surgery to remove the tumor, and radiation therapy to shrink or kill the tumor cells. The best treatment approach depends on factors such as the size and location of the tumor, the patient's age and overall health, and their personal preferences.

Meningoencephalitis is a medical term that refers to an inflammation of both the brain (encephalitis) and the membranes covering the brain and spinal cord (meninges), known as the meninges. It is often caused by an infection, such as bacterial or viral infections, that spreads to the meninges and brain. In some cases, it can also be caused by other factors like autoimmune disorders or certain medications.

The symptoms of meningoencephalitis may include fever, headache, stiff neck, confusion, seizures, and changes in mental status. If left untreated, this condition can lead to serious complications, such as brain damage, hearing loss, learning disabilities, or even death. Treatment typically involves antibiotics for bacterial infections or antiviral medications for viral infections, along with supportive care to manage symptoms and prevent complications.

Meningeal carcinomatosis, also known as leptomeningeal metastasis or neoplastic meningitis, is a medical condition characterized by the spread of cancer cells to the meninges, which are the thin layers of tissue that cover and protect the brain and spinal cord.

In this condition, cancer cells from a primary tumor or metastatic cancer elsewhere in the body invade the cerebrospinal fluid (CSF) and spread throughout the meningeal spaces, causing inflammation and damage to the surrounding tissues. This can result in various neurological symptoms such as headache, nausea, vomiting, seizures, confusion, weakness, or paralysis, depending on the location of the cancer cells in the meninges.

Meningeal carcinomatosis is a serious and often life-threatening complication of advanced cancer, with a poor prognosis and limited treatment options. It can occur in various types of cancer, including lung, breast, melanoma, and hematological malignancies such as leukemia and lymphoma. Early diagnosis and prompt treatment are crucial to improve the quality of life and prolong survival in affected patients.

Cerebrospinal fluid (CSF) is a clear, colorless fluid that surrounds and protects the brain and spinal cord. It acts as a shock absorber for the central nervous system and provides nutrients to the brain while removing waste products. CSF is produced by specialized cells called ependymal cells in the choroid plexus of the ventricles (fluid-filled spaces) inside the brain. From there, it circulates through the ventricular system and around the outside of the brain and spinal cord before being absorbed back into the bloodstream. CSF analysis is an important diagnostic tool for various neurological conditions, including infections, inflammation, and cancer.

  • In anatomy, the meninges (/məˈnɪndʒiːz/, SG: meninx (/ˈmiːnɪŋks/ or /ˈmɛnɪŋks/), from Ancient Greek μῆνιγξ (mēninx) 'membrane') are the three membranes that envelop the brain and spinal cord. (wikipedia.org)
  • The three membranes that cover the brain and spinal cord (singular: meninx). (rxlist.com)
  • However, ERC and PRC are commonly over-segmented in T1-weighted MRI (T1w MRI) because of the adjacent meninges, which consist of three layers of membranes, including dura mater, arachnoid mater and pia mater, and envelop the brain and spinal cord. (upenn.edu)
  • By releasing the meninges properly you will also help all the membranes of the body, help modify the tensions inside the cranium, thorax, abdomen, and pelvis, ​and support the flow of intracerebral sinuses including sagittal sinuses, straight sinuses, the vein of Galen, the vein of Rosendal, etc. (thelivingwellco.com.sg)
  • In mammals, the meninges are the dura mater, the arachnoid mater, and the pia mater. (wikipedia.org)
  • The dura mater (Latin: tough mother) (also rarely called meninx fibrosa or pachymeninx) is a thick, durable membrane, closest to the skull and vertebrae. (wikipedia.org)
  • The outside meninx is called the dura mater, and is the most resilient of the three. (rxlist.com)
  • around the brain and spinal cord called the meninges (pronounced: meh-NIN-jeez). (kidshealth.org)
  • One common approach to studying drug transfer across the spinal meninges has been the use of a classical diffusion cell model, in which a section of the meninges is mounted in vitro into a diffusion cell apparatus. (asahq.org)
  • Some of these studies have used fresh spinal meninges obtained from living animals, [1-4] whereas others have relied on cadaveric human tissue previously frozen for variable periods of time before study. (asahq.org)
  • still, diffusion cell studies using fresh and frozen meningeal tissues continue to be submitted to anesthesia journals for publication (personal observation, C.M.B.). To address this concern, we directly compared the permeability of morphine through fresh and dry-frozen spinal meninges. (asahq.org)
  • We measured the permeability of morphine through fresh spinal meninges obtained from anesthetized monkeys and then repeated this measurement through the same tissues after they were dry-frozen at -20 [degree sign]C. (asahq.org)
  • The cranial meninges are continuous with, and similar to, the spinal meninges through the foramen magnum. (mhmedical.com)
  • Pictured above is an exclusive preview of our new Scalp & Meninges detailed model, coming this summer to Complete Anatomy. (3d4medical.com)
  • This medical illustration series depicts a cross-sectional view of the normal anatomy of the brain, spinal cord and meninges. (nucleusmedicalmedia.com)
  • 2014). Anatomy of the meninges. (mhmedical.com)
  • In mice injected with α-synuclein (α-syn) preformed fibrils, we showed that the emergence of α-syn pathology was followed by delayed meningeal lymphatic drainage, loss of tight junctions among meningeal lymphatic endothelial cells and increased inflammation of the meninges. (lu.se)
  • Fig. 8.34 ), which are continuous through the foramen magnum with the cranial meninges. (pediagenosis.com)
  • Inflammation of the meninges ( meningitis ) can occur due to bacterial infection. (rxlist.com)
  • The specific tensegrity work on the cranial meninges is extremely important, for example, for conditions such as motor vehicle accidents, strokes, chronic headaches as well as for children with cerebral palsy, autistic spectrum disorders, Down syndrome, chronic meningitis, etc. (thelivingwellco.com.sg)
  • Meningitis is the term used to describe the Enteroviruses are responsible for approxima- inflammation of the brain meninges, and it is the tely 90% of cases of aseptic meningitis. (bvsalud.org)
  • The SLYM is located in the subarachnoid space, the space between the middle reticular meninges and the innermost tender meninges that lie close to the brain. (wikipedia.org)
  • The arachnoid is connected to the pia mater by numerous delicate strands that cross the subarachnoid space between the two meninges. (pediagenosis.com)
  • The middle element of the meninges is the arachnoid mater, or arachnoid membrane, so named because of its resemblance to a spider web. (wikipedia.org)
  • The arachnoid mater is the middle tissue of the meninges. (medicalnewstoday.com)
  • For økt beskyttelse er den utstyrt med MIPS, en rotasjonsteknologi som hjelper til ved ekstra harde slag. (skistar.com)
  • Separating the scalp and meninges are the cranial bones. (3d4medical.com)
  • The meninges are found beneath the cranial bones. (3d4medical.com)
  • We will work with a specific concept of stress bands and reinforcement of the cranial bones ("buttresses") that can indicate problems with the meninges. (thelivingwellco.com.sg)
  • After allowing 30 min for equilibration to 37 [degree sign]C, the study drug was added to the epidural side of the meninges. (asahq.org)
  • Like the spinal cord, the brain is covered and partially protected by connective tissue meninges. (lumenlearning.com)
  • A congenital or acquired protrusion of the meninges, unaccompanied by neural tissue, through a bony defect in the skull or vertebral column. (bvsalud.org)
  • The subarachnoid lymphatic-like membrane (SLYM) is a highly debated anatomical structure in the human brain that was proposed in 2023 as a possible fourth layer of the meninges. (wikipedia.org)
  • An all-encompassing protective layer, the Meninx is as influenced by science, and the body's own meninges which protect the central nervous system, as it is by classic ski helmets. (s3-swiss.ch)
  • If a person were to take a "slice" of the spinal cord horizontally, they would see a circular area in the middle covered in protective layers (the meninges). (medicalnewstoday.com)
  • The primary function of the meninges is to protect the central nervous system. (wikipedia.org)
  • The nerves in the spinal cord are surrounded by several thin tissues, called meninges, which provide cushioning and protection. (medicalnewstoday.com)
  • Our evaluation also showed that the proposed pipeline using T1w MRI is not as reliable or accurate as T2-based segmentation of ERC and PRC, which could due to the poorer ability to resolve GM boundaries limited by low resolution and the confound of meninges in T1w MRI. (upenn.edu)
  • A hollow space that contains the spinal cord and meninges. (github.io)
  • The likely mislabeling of meninges as GM by intensity-based methods using T1w MRI would introduce errors to the quantification of ERC and PRC, potentially confounding the findings of research studies by generating incorrect measurements. (upenn.edu)
  • This volume offers a synthesis of the multifaceted results of a Tunisian-German research project carried out at the ancient seaport of Meninx on Djerba. (reichert-verlag.de)
  • The rate at which a study drug diffuses through the meninges from a donor reservoir to the recipient reservoir is quantified to the permeability of the coefficient of the drug. (asahq.org)
  • By contrast, in T2w MRI, meninges are easy to separate from GM due to their dark appearance in T2 contrast (Figure 2b). (upenn.edu)

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