Loratadine
Histamine H1 Antagonists, Non-Sedating
Histamine H1 Antagonists
Anti-Allergic Agents
Rhinitis, Allergic, Perennial
Pseudoephedrine
Cyproheptadine
Sneezing
Ketoconazole
Rhinitis, Allergic, Seasonal
Promethazine
Consumer Product Safety
Drug Utilization Review
Comparison of intranasal triamcinolone acetonide with oral loratadine in the treatment of seasonal ragweed-induced allergic rhinitis. (1/86)
A double-blind, randomized, multicenter, parallel-group controlled study compared the efficacy and safety of intranasal triamcinolone acetonide (220 micrograms/day) and oral loratadine (10 mg/day) in patients with at least two seasons of ragweed-induced seasonal allergic rhinitis. A 28-day screening period, including a 5-day baseline period, preceded a 4-week treatment period. Reduction in rhinitis symptom scores was evident in both groups as early as day 1, with no significant between-group differences during week 1. At weeks 2, 3, and 4, patients treated with triamcinolone acetonide were significantly (P < 0.05) more improved in total nasal score, nasal itch, nasal stuffiness, and sneezing than were patients treated with loratadine. At weeks 3 and 4, rhinorrhea and ocular symptoms were significantly (P < 0.05) more improved from baseline among triamcinolone acetonide patients compared with loratadine patients. There was no significant between-group difference in relief from postnasal drip at any time point. Physicians' global evaluations significantly (P = 0.002) favored triamcinolone acetonide at the final visit, with moderate to complete relief of symptoms attained by 68% of triamcinolone acetonide patients and 59% of loratadine patients. Over the 4-week treatment period, triamcinolone acetonide patients had significantly greater improvement in total nasal score, nasal itch, nasal stuffiness, sneezing, and ocular symptoms. Both treatments were well tolerated, with headache being the most frequently reported drug-related adverse effect in both the triamcinolone acetonide (15%) and loratadine (11%) groups. These results indicate that triamcinolone acetonide is more effective than oral loratadine in relieving the symptoms of ragweed-induced seasonal allergic rhinitis. (+info)Rate-dependent blockade of a potassium current in human atrium by the antihistamine loratadine. (2/86)
The antihistamine loratadine is widely prescribed for the treatment of symptoms associated with allergies. Although generally believed to be free of adverse cardiac effects, there are a number of recent reports suggesting that loratadine use may be associated with arrhythmias, in particular atrial arrhythmias. Nothing is known regarding the potassium channel blocking properties of loratadine in human cardiac cells. Using the whole-cell patch clamp technique, the effects of loratadine on the transient outward K current (Ito), sustained current (Isus), and current measured at -100 mV (IK1 and Ins), the major inward and outward potassium currents present in human atrial myocytes, were examined in order to provide a possible molecular mechanism for the observed atrial arrhythmias reported with loratadine use. Loratadine rate-dependently inhibited Ito at therapeutic concentrations with 10 nM loratadine reducing Ito amplitude at a pacing rate of 2 Hz by 34.9+/-6.0%. In contrast, loratadine had no effect on either Isus or current measured at -100 mV. These results may provide a possible mechanism for the incidences of supraventricular arrhythmias reported with the use of loratadine. (+info)Risk of ventricular arrhythmias associated with nonsedating antihistamine drugs. (3/86)
AIMS: To quantify and compare the incidence of ventricular arrhythniias associated with the use of five nonsedating antihistamines: acrivastine, astemizole, cetirizine, loratadine and terfenadine. The effects of age, sex, dose, duration of treatment, and the interaction with P450 inhibitor drugs were also examined. METHODS: We carried out a cohort study with a nested case-control analysis using the UK-based General Practice Research database (GPRD). The study cohort included persons aged less than 80 years old who received their first prescription for any of the five study drugs between January 1, 1992 and September 30, 1996. We estimated relative risks and 95% confidence intervals of idiopathic ventricular arrhythmias with current use of antihistamines as compared with non use. RESULTS: The study cohort included 197425 persons who received 513012 prescriptions. Over the study period 18 valid cases of idiopathic ventricular arrhythmias were detected. Nine occurred during the current use of any antihistamine, resulting in a crude incidence of 1.9 per 10000 person-years (95%CI: 1.0-3.6) and a relative risk of 4.2 (95%CI: 1.5-11.8) as compared with non use. Astemizole presented the highest relative risk (RR= 19.0; 95%CI: 4.8-76.0) of all study drugs, while terfenadine (RR=2.1; 95%CI:0.5-8.5) was in the range of other nonsedating antihistamines. Older age was associated with a greater risk of ventricular arrhythmias (RR=7.4; 95%CI: 2.6-21.4) and seemed to increase the effect of antihistamines (RR=6.4; 95%CI: 1.7-24.8). The proportions of high dose terfenadine and the concomitant use with P450 inhibitors among current users of terfenadine were 2.7% and 3.4%, respectively over the study period with no single case of ventricular arrhythmias occurring in the presence of these two risk factors. CONCLUSIONS: The use of nonsedating antihistamines increases the risk of ventricular arrhythmias by a factor of four in the general population. Yet, the absolute effect is quite low requiring 57000 prescriptions, or 5300 person-years of use for one case to occur. The risk associated with terfenadine was no different from that with other nonsedating antihistamines. (+info)A double-blind, placebo-controlled investigation of the effects of fexofenadine, loratadine and promethazine on cognitive and psychomotor function. (4/86)
AIMS: To assess whether fexofenadine in a range of doses from 80 to 180 mg has any disruptive effects on aspects of psychomotor and cognitive function in comparison with placebo, loratadine and promethazine, an antihistamine known to produce psychomotor and cognitive impairment. METHODS: Twenty-four healthy volunteers received fexofenadine 80 mg, 120 mg and 180 mg, loratadine 10 mg, promethazine 30 mg (as a positive internal control) and placebo in a six-way crossover, double-blind study. Following each dose, subjects were required to perform a series of tests of cognitive function and psychomotor performance at 1.5, 3, 6, 9, 12 and 24 h post dose. The test battery included critical flicker fusion (CFF), choice reaction time (CRT) and assessment of subjective sedation (LARS). Overall levels of activity were monitored by means of wrist mounted actigraphs throughout each of the 24 h experimental periods. RESULTS: Fexofenadine at all doses tested was not statistically different from placebo in any of the tests used and loratadine did not cause any significant impairment of cognitive function. Significant impairments were found following promethazine. Promethazine caused a significant reduction in CFF threshold and this effect was evident up to 12 h post dose (P<0.05). There was a significant increase in recognition reaction time at 3 and 6 h post promethazine administration, and the drug caused a significant (P<0. 002) increase in the percentage of 'sleep-like' activity from actigraph records during the daytime. CONCLUSIONS: Fexofenadine at doses up to 180 mg appears free from disruptive effects on aspects of psychomotor and cognitive function in a study where the psychometric assessments have been shown to be sensitive to impairment, as evidenced by the effects of the verum control promethazine 30 mg. (+info)Comparison of the response to histamine challenge of the nose and the maxillary sinus: effect of loratadine. (5/86)
To study the response of the maxillary sinus to histamine provocation, we performed a double-blind, randomized, crossover trial during which nonallergic subjects without symptoms of rhinitis (n = 25) received either 10 mg loratadine or placebo once daily for a week and then underwent nasal challenge with histamine (3, 10, and 30 mg/ml) followed, 24 h later, by a maxillary sinus challenge while still receiving the medication. Nasal challenge with histamine led to significant increases in vascular permeability, reflex nasal secretions, sneezing, and other nasal symptoms. Sinus challenge resulted in significant increases in vascular permeability within the sinus cavity (P < 0.01) and some nasal symptoms but no significant change in reflex nasal secretions. The response of the sinus mucosa to histamine was lower in magnitude than that of the nose. Treatment with loratadine resulted in a significant inhibition of the histamine-induced changes in both nasal and sinus cavities. Our data suggest the lack of a sinonasal reflex response to histamine provocation of the maxillary sinus of nonallergic individuals. (+info)Loratadine blockade of K(+) channels in human heart: comparison with terfenadine under physiological conditions. (6/86)
Recently, there has been considerable attention focused on drugs that prolong the QT interval of the electrocardiogram, with the H(1)-receptor antagonist class of drugs figuring prominently. Albeit rare, incidences of QT prolongation and ventricular arrhythmias, in particular torsade de pointes, have been reported with the antihistamines astemizole and terfenadine and more recently with loratadine. The most likely mechanism for these drug-related arrhythmias is blockage of one or more ion channels involved in cardiac repolarization. Several studies have demonstrated block of multiple cardiac K(+) channels by terfenadine, including I(to), I(sus), I(K1), and I(Kr) or human ether-a-go-go-related gene (HERG). In contrast to terfenadine, previous studies have shown the antihistamine loratadine to be virtually free of cardiac ion channel-blocking effects. This disparity in the lack of any significant cardiac ion channel-blocking effect and the existence of numerous adverse cardiac event reports for loratadine prompted the comparison of the human cardiac K(+) channel-blocking profile for loratadine and terfenadine under physiological conditions [37 degrees C, holding potential (V(hold)) = -75 mV] with the whole-cell patch-clamp method. Isolated human atrial myocytes were used to examine drug effects on I(to), I(sus), and I(K1), whereas HERG was studied in stably transfected HEK cells. In contrast to previous studies in nonhuman systems and/or under nonphysiological conditions, terfenadine (1 microM) had no effect on I(to), I(sus), or I(K1) at pacing rates up to 3 Hz. Similar results were found for 1 microM loratadine. However, both drugs potently blocked HERG current amplitude, with a mean IC(50) of 173 nM for loratadine and 204 nM for terfenadine (pacing rate, 0.1 Hz). Neither drug exhibited any significant use-dependent blockage of HERG (pacing rates = 0.1-3 Hz). These results point to a similarity in the human cardiac K(+) channel-blocking effects of loratadine and terfenadine and provide a possible mechanism for the arrhythmias associated with the use of either drug. (+info)Sedation with "non-sedating" antihistamines: four prescription-event monitoring studies in general practice. (7/86)
OBJECTIVES: To investigate the frequency with which sedation was reported in post-marketing surveillance studies of four second generation antihistamines: loratadine, cetirizine, fexofenadine, and acrivastine. DESIGN: Prescription-event monitoring studies. SETTING: Prescriptions were obtained for each cohort in the immediate post-marketing period. SUBJECTS: Event data were obtained for a total of 43 363 patients. MAIN OUTCOME MEASURES: Reporting of sedation or drowsiness. RESULTS: The odds ratios (adjusted for age and sex) for the incidence of sedation were 0.63 (95% confidence interval 0.36 to 1.11; P=0.1) for fexofenadine; 2.79 (1.69 to 4.58; P<0.0001) for acrivastine, and 3.53 (2.07 to 5.42; P<0.0001) for cetirizine compared with loratadine. No increased risk of accident or injury was evident with any of the four drugs. CONCLUSIONS: Although the risk of sedation was low with all four drugs, fexofenadine and loratadine may be more appropriate for people working in safety critical jobs. (+info)Evaluation of the pharmacokinetics and electrocardiographic pharmacodynamics of loratadine with concomitant administration of ketoconazole or cimetidine. (8/86)
AIMS: To evaluate whether ketoconazole or cimetidine alter the pharmacokinetics of loratadine, or its major metabolite, desloratadine (DCL), or alter the effects of loratadine or DCL on electrocardiographic repolarization in healthy adult volunteers. METHODS: Two randomized, evaluator-blind, multiple-dose, three-way crossover drug interaction studies were performed. In each study, subjects received three 10 day treatments in random sequence, separated by a 14 day washout period. The treatments were loratadine alone, cimetidine or ketoconazole alone, or loratadine plus cimetidine or ketoconazole. The primary study endpoint was the difference in mean QTc intervals from baseline to day 10. In addition, plasma concentrations of loratadine, DCL, and ketoconazole or cimetidine were obtained on day 10. RESULTS: Concomitant administration of loratadine and ketoconazole significantly increased the loratadine plasma concentrations (307%; 90% CI 205-428%) and DCL concentrations (73%; 62-85%) compared with administration of loratadine alone. Concomitant administration of loratadine and cimetidine significantly increased the loratadine plasma concentrations (103% increase; 70-142%) but not DCL concentrations (6% increase; 1-11%) compared with administration of loratadine alone. Cimetidine or ketoconazole plasma concentrations were unaffected by coadministration with loratadine. Despite increased concentrations of loratadine and DCL, there were no statistically significant differences for the primary electrocardiographic repolarization parameter (QTc) among any of the treatment groups. No other clinically relevant changes in the safety profile of loratadine were observed as assessed by electrocardiographic parameters (mean (90% CI) QTc changes: loratadine vs loratadine + ketoconazole = 3.6 ms (-2.2, 9.4); loratadine vs loratadine + cimetidine = 3.2 ms (-1.6, 7.9)), clinical laboratory tests, vital signs, and adverse events. CONCLUSIONS: Loratadine 10 mg daily was devoid of any effects on electrocardiographic parameters when coadministered for 10 days with therapeutic doses of ketoconazole or cimetidine in healthy volunteers. It is concluded that, although there was a significant pharmacokinetic drug interaction between ketoconazole or cimetidine and loratadine, this effect was not accompanied by a change in the QTc interval in healthy adult volunteers. (+info)Loratadine is an antihistamine medication that is commonly used to relieve symptoms of allergies, such as hay fever, hives, and other skin reactions. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. Loratadine is available over-the-counter in various forms, including tablets, capsules, and syrup.
The medical definition of loratadine is: "A second-generation antihistamine used for the symptomatic treatment of allergies, including hay fever, hives, and other skin reactions. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms."
It's important to note that while loratadine is generally considered safe, it can cause side effects such as dizziness, dry mouth, and headache. If you have any concerns about taking loratadine or experience severe side effects, you should speak with your healthcare provider.
Histamine H1 antagonists, non-sedating, also known as second-generation antihistamines, are medications that block the action of histamine at the H1 receptor without causing significant sedation. Histamine is a chemical mediator released by mast cells and basophils in response to an allergen, leading to allergic symptoms such as itching, sneezing, runny nose, and hives.
The non-sedating antihistamines have a higher affinity for the H1 receptor and are less lipophilic than first-generation antihistamines, which results in less penetration of the blood-brain barrier and reduced sedative effects. Examples of non-sedating antihistamines include cetirizine, levocetirizine, loratadine, desloratadine, fexofenadine, and rupatadine. These medications are commonly used to treat allergic rhinitis, urticaria, and angioedema.
Histamine H1 antagonists, also known as H1 blockers or antihistamines, are a class of medications that work by blocking the action of histamine at the H1 receptor. Histamine is a chemical mediator released by mast cells and basophils in response to an allergic reaction or injury. It causes various symptoms such as itching, sneezing, runny nose, and wheal and flare reactions (hives).
H1 antagonists prevent the binding of histamine to its receptor, thereby alleviating these symptoms. They are commonly used to treat allergic conditions such as hay fever, hives, and eczema, as well as motion sickness and insomnia. Examples of H1 antagonists include diphenhydramine (Benadryl), loratadine (Claritin), cetirizine (Zyrtec), and doxylamine (Unisom).
Anti-allergic agents, also known as antihistamines, are a class of medications used to treat allergies. They work by blocking the action of histamine, a substance in the body that is released during an allergic reaction and causes symptoms such as itching, sneezing, runny nose, and watery eyes.
There are two main types of antihistamines: first-generation and second-generation. First-generation antihistamines, such as diphenhydramine (Benadryl) and chlorpheniramine (Chlor-Trimeton), can cause drowsiness and other side effects, such as dry mouth and blurred vision. They are typically used for the treatment of short-term symptoms, such as those caused by seasonal allergies or a mild reaction to an insect bite.
Second-generation antihistamines, such as loratadine (Claritin) and cetirizine (Zyrtec), are less likely to cause drowsiness and other side effects. They are often used for the long-term treatment of chronic allergies, such as those caused by dust mites or pet dander.
In addition to their use in treating allergies, antihistamines may also be used to treat symptoms of motion sickness, insomnia, and anxiety. It is important to follow the instructions on the label when taking antihistamines and to talk to a healthcare provider if you have any questions or concerns about using these medications.
Butyrophenones are a group of synthetic antipsychotic drugs that are primarily used to treat symptoms of schizophrenia and other psychotic disorders. They act as dopamine receptor antagonists, which means they block the action of dopamine, a neurotransmitter in the brain associated with mood, motivation, and pleasure.
Some examples of butyrophenones include haloperidol, droperidol, and benperidol. These drugs are known for their potent antipsychotic effects and can also be used to manage agitation, aggression, and other behavioral disturbances in patients with various psychiatric and neurological disorders.
In addition to their antipsychotic properties, butyrophenones have been used off-label for their sedative and analgesic effects. However, they are associated with a range of side effects, including extrapyramidal symptoms (EPS), such as involuntary muscle spasms and tremors, as well as other neurological and cardiovascular adverse reactions. Therefore, their use is typically reserved for cases where other treatments have been ineffective or contraindicated.
Allergic rhinitis, perennial type, is a medical condition characterized by inflammation of the nasal passages caused by an allergic response to environmental allergens that are present throughout the year. Unlike seasonal allergic rhinitis, which is triggered by specific pollens or molds during certain times of the year, perennial allergic rhinitis is a persistent condition that occurs year-round.
Common allergens responsible for perennial allergic rhinitis include dust mites, cockroaches, pet dander, and indoor mold spores. Symptoms may include sneezing, runny or stuffy nose, itchy eyes, ears, throat, or roof of the mouth. Treatment options typically involve avoiding exposure to the offending allergens, if possible, as well as medications such as antihistamines, nasal corticosteroids, and leukotriene receptor antagonists to manage symptoms. Immunotherapy (allergy shots) may also be recommended for long-term management in some cases.
Pseudoephedrine is a decongestant medication that works by narrowing the blood vessels in the lining of the nose, which can help to relieve nasal congestion. It is commonly used to treat symptoms of allergies, colds, and sinusitis. Pseudoephedrine is available over-the-counter in various forms, including tablets, capsules, and liquids.
It is important to note that pseudoephedrine has been misused in the production of methamphetamine, a highly addictive and illegal drug. As a result, some countries have implemented regulations on the sale of products containing pseudoephedrine, requiring them to be sold behind the counter or kept in locked cases.
Cyproheptadine is an antihistamine and anticholinergic medication that is primarily used to treat symptoms of allergies, such as runny nose, sneezing, and itching. It works by blocking the action of histamine, a substance in the body that causes allergic reactions.
Cyproheptadine also has other uses, including the treatment of migraines and cluster headaches, appetite stimulation in people with certain medical conditions, and as a sedative in some cases. It is available in various forms, such as tablets, capsules, and syrup.
Like all medications, cyproheptadine can have side effects, including drowsiness, dry mouth, dizziness, and blurred vision. It is important to follow the dosage instructions carefully and talk to a healthcare provider if you experience any bothersome or persistent side effects.
Sneezing is an involuntary, forceful expulsion of air through the nose and mouth, often triggered by irritation or inflammation in the nasal passages. It is a protective reflex that helps to clear the upper respiratory tract of irritants such as dust, pollen, or foreign particles. The sneeze begins with a deep inspiration of air, followed by closure of the glottis (the opening between the vocal cords) and contraction of the chest and abdominal muscles. This builds up pressure in the lungs, which is then suddenly released through the nose and mouth as the glottis opens and the velum (the soft tissue at the back of the roof of the mouth) rises to block the nasal passage. The result is a powerful burst of air that can travel at speeds of up to 100 miles per hour, expelling mucus and any trapped irritants along with it.
Ketoconazole is an antifungal medication that is primarily used to treat various fungal infections, including those caused by dermatophytes, Candida, and pityrosporum. It works by inhibiting the synthesis of ergosterol, a crucial component of fungal cell membranes, which leads to increased permeability and ultimately results in fungal cell death.
Ketoconazole is available as an oral tablet for systemic use and as a topical cream or shampoo for localized applications. The oral formulation is used to treat severe or invasive fungal infections, while the topical preparations are primarily indicated for skin and scalp infections, such as athlete's foot, ringworm, jock itch, candidiasis, and seborrheic dermatitis.
Common side effects of oral ketoconazole include nausea, vomiting, headache, and altered liver function tests. Rare but serious adverse reactions may include hepatotoxicity, adrenal insufficiency, and interactions with other medications that can affect the metabolism and elimination of drugs. Topical ketoconazole is generally well-tolerated, with local irritation being the most common side effect.
It's important to note that due to its potential for serious liver toxicity and drug-drug interactions, oral ketoconazole has been largely replaced by other antifungal agents, such as fluconazole and itraconazole, which have more favorable safety profiles. Topical ketoconazole remains a valuable option for treating localized fungal infections due to its effectiveness and lower risk of systemic side effects.
Allergic rhinitis, seasonal (also known as hay fever) is a type of inflammation in the nose which occurs when an individual breathes in allergens such as pollen or mold spores. The immune system identifies these substances as harmful and releases histamine and other chemicals, causing symptoms such as sneezing, runny or stuffy nose, red, watery, and itchy eyes, cough, and fatigue. Unlike perennial allergic rhinitis, seasonal allergic rhinitis is worse during specific times of the year when certain plants pollinate.
Promethazine is an antihistamine and phenothiazine derivative, which is commonly used for its sedative, anti-emetic (prevents vomiting), and anti-allergic properties. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms, and by blocking the action of dopamine, a neurotransmitter in the brain that helps transmit signals.
Promethazine is used to treat various conditions such as allergies, motion sickness, nausea and vomiting, and as a sedative before and after surgery or medical procedures. It may also be used for its calming effects in children with certain behavioral disorders.
Like all medications, promethazine can have side effects, including drowsiness, dry mouth, blurred vision, and dizziness. More serious side effects may include seizures, irregular heartbeat, and difficulty breathing. It is important to follow the instructions of a healthcare provider when taking promethazine and to report any unusual symptoms or side effects promptly.
Nonprescription drugs, also known as over-the-counter (OTC) drugs, are medications that can be legally purchased without a prescription from a healthcare professional. They are considered safe and effective for treating minor illnesses or symptoms when used according to the directions on the label. Examples include pain relievers like acetaminophen and ibuprofen, antihistamines for allergies, and topical treatments for skin conditions. It is still important to follow the recommended dosage and consult with a healthcare provider if there are any concerns or questions about using nonprescription drugs.
Consumer Product Safety refers to the measures taken to ensure that products intended for consumer use are free from unreasonable risks of injury or illness. This is typically overseen by regulatory bodies, such as the Consumer Product Safety Commission (CPSC) in the United States, which establishes safety standards, tests products, and recalls dangerous ones.
The definition of 'Consumer Product' can vary but generally refers to any article, or component part thereof, produced or distributed (i) for sale to a consumer for use in or around a permanent or temporary household or residence, a school, in recreation, or otherwise; (ii) for the personal use, consumption or enjoyment of a consumer in or around a permanent or temporary household or residence, a school, in recreation, or otherwise; (iii) for sensory evaluation and direct physical contact by a consumer in or around a permanent or temporary household or residence, a school, in recreation, or otherwise.
The safety measures can include various aspects such as design, manufacturing, packaging, and labeling of the product to ensure that it is safe for its intended use. This includes ensuring that the product does not contain any harmful substances, that it functions as intended, and that it comes with clear instructions for use and any necessary warnings.
It's important to note that even with these safety measures in place, it is still possible for products to cause injury or illness if they are used improperly or if they malfunction. Therefore, it is also important for consumers to be aware of the risks associated with the products they use and to take appropriate precautions.
A Drug Utilization Review (DUR) is a systematic retrospective examination of a patient's current and past use of medications to identify medication-related problems, such as adverse drug reactions, interactions, inappropriate dosages, duplicate therapy, and noncompliance with the treatment plan. The goal of DUR is to optimize medication therapy, improve patient outcomes, reduce healthcare costs, and promote safe and effective use of medications.
DUR is typically conducted by pharmacists, physicians, or other healthcare professionals who review medication records, laboratory results, and clinical data to identify potential issues and make recommendations for changes in medication therapy. DUR may be performed manually or using automated software tools that can analyze large datasets of medication claims and electronic health records.
DUR is an important component of medication management programs in various settings, including hospitals, long-term care facilities, managed care organizations, and ambulatory care clinics. It helps ensure that patients receive the right medications at the right doses for the right indications, and reduces the risk of medication errors and adverse drug events.
Loratadine
H1 antagonist
Tricyclic
Desloratadine
Cold medicine
Suplatast tosilate
Levocetirizine
Azatadine
Pollen
Drugs in pregnancy
Cetirizine
Montelukast
Over-the-counter drug
Eriksen flanker task
KCNA5
Rhinovirus
Phenylephrine
Pseudoephedrine
Antihistamine
Diphenhydramine
Ze339
Dimetapp
Basopenia
Cimetidine
Basophil
Aquagenic pruritus
Pruritic urticarial papules and plaques of pregnancy
Prodrug
Allergic rhinitis
Ebastine
Antihistamine16
- As a "non-sedating" antihistamine, loratadine causes less (but still significant, in some cases) sedation and psychomotor retardation than the older antihistamines, because it penetrates the blood/brain barrier less. (wikipedia.org)
- Loratadine is a tricyclic antihistamine, which acts as a selective inverse agonist of peripheral histamine H1 receptors. (wikipedia.org)
- Schering-Plough developed loratadine as part of a quest for a potential blockbuster drug: a nonsedating antihistamine. (wikipedia.org)
- By the time Schering submitted the drug to the U.S. Food and Drug Administration (FDA) for approval, the agency had already approved a competitor's nonsedating antihistamine, terfenadine (trade name Seldane), and, therefore, put loratadine on a lower priority. (wikipedia.org)
- In 2002, a study in Sweden noted that among male infants born to women who while pregnant had taken loratadine (Claritin ® ), a nonsedating antihistamine commonly used for seasonal allergies, hypospadias prevalence was twice that of the general population ( 1 ). (cdc.gov)
- Loratadine, the active element in this medication is a long-acting tricyclic antihistamine which prevents the actions of a biochemical mediator called histamine, a chemical which is a controller of allergic reactions in the body. (mynetpharma.com)
- Generic Loratadine contains 10mg of micronized loratadine, an antihistamine, to be administered orally. (mynetpharma.com)
- Loratadine is an antihistamine - a type of medicine commonly used to treat allergic conditions. (lloydspharmacy.com)
- each 5 mL contains): Loratadine 5mg (Antihistamine). (myotcstore.com)
- Loratadine may be included in antihistamine trials for allergic skin diseases. (vin.com)
- Claritin (loratadine) is an antihistamine that reduces the effect of the natural chemical histamine in the body. (novalarpharm.com)
- Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis. (allergostore.com)
- Loratadine includes 10mg of an active ingredient called Loratadine, which is an antihistamine. (pharmacyplanet.com)
- They contain the active ingredient loratadine, which is an antihistamine. (ambicapharmacy.com)
- Loratadine Tablets 10 MG offered by us, are an antihistamine that is used to reduce the symptoms of hay fever and other allergies. (brixpharma.com)
- Sedaghat suggests taking a second-generation OTC antihistamine that's less likely to cause drowsiness, such as fexofenadine (Allegra), loratadine, or cetirizine (Zyrtec). (snackroots.com)
10mg4
- Allergy & Hayfever Relief 30 Days contains 10mg of Loratadine for relief from hayfever, seasonal allergies, skin allergies, and hives. (nasalcongestion.eu)
- What is Loratadine 10mg side effects? (snackroots.com)
- No, the maximum recommended daily dose of loratadine is 10mg once daily. (snackroots.com)
- Each tablet contains 10mg loratadine. (mccormackspharmacy.ie)
Antihistamines13
- Loratadine is in a class of medications called antihistamines. (medlineplus.gov)
- Use of nonsedating antihistamines (including loratadine) and sedating antihistamines also were not associated with hypospadias. (cdc.gov)
- Comparative assessment of environmental risk when using the antihistamines desloratadine, cetirizine, loratadine, ebastine, clemastine and fexofenadine from a Swedish perspective (Report Goodpoint 2019). (janusinfo.se)
- Generic Loratadine comprises of Loratadine as an active ingredient which belongs to the pharmacological class of tricyclic antihistamines. (mynetpharma.com)
- Loratadine represents a new generation of antihistamines that does not cross the blood-brain barrier and does not cause drowsiness. (vin.com)
- Loratadine, a member of the piperidine class of antihistamines, has gotten relatively positive reviews in particular for treating feline itchy skin, but actual published studies are few. (vin.com)
- Traditional antihistamines such as diphenhydramine are used to combat the histamine released by the tumor but loratadine could also be used. (vin.com)
- Due to their lack of sedative and CNS adverse effects, loratadine along with other second generation antihistamines have become preferable over their 1st generation counterparts in many clinical situations. (allergostore.com)
- Antihistamines work to block histamine cells, resulting in Loratadine tablets directly blocking the cause of allergy symptoms in the body. (pharmacyplanet.com)
- Loratadine is a medication that helps reduce itchiness caused by allergies by blocking the effects of histamine, and may also be used as an additional treatment for itching related to certain types of cancers in animals, but its effectiveness can vary and may be used in combination with other antihistamines. (northwestcompounders.com)
- Both cetirizine and loratadine are nonsedating antihistamines. (snackroots.com)
- It is similar to other second-generation antihistamines including loratadine (Claritin), fexofenadine (Allegra) and azelastine (Astelin). (snackroots.com)
- Benadryl (diphenhydramine) and Claritin (loratadine) are antihistamines used to treat allergy symptoms, such as itching, hives, runny nose, watery eyes, and sneezing from hay fever (allergic rhinitis) and other allergies, such as allergies to molds and dust mites. (snackroots.com)
Tablets14
- Although tablets such as loratadine and Telfast can prove invaluable, several factors have been linked to the severity of hay fever symptoms. (lloydspharmacy.com)
- Administration of CLARITIN REDITABS (loratadine rapidly-disintegrating tablets): Place CLARITIN REDITABS (loratadine rapidly-disintegrating tablets) on the tongue. (novalarpharm.com)
- Loratadine disintegrating tablets (Claritin Reditab) may contain phenylalanine. (novalarpharm.com)
- Loratadine tablets are a medication used to relieve symptoms associated with allergies, such as hay fever, allergic rhinitis, and hives. (ambicapharmacy.com)
- This short description provides key information and answers frequently asked questions about Loratadine tablets. (ambicapharmacy.com)
- Loratadine tablets are a non-prescription (over-the-counter) medication used to alleviate symptoms caused by allergies. (ambicapharmacy.com)
- Q: What are the uses of Loratadine Tablets? (ambicapharmacy.com)
- Loratadine tablets are primarily used to relieve symptoms associated with seasonal allergies, such as sneezing, itching, runny nose, and watery eyes. (ambicapharmacy.com)
- Q: How do Loratadine Tablets work? (ambicapharmacy.com)
- Loratadine tablets work by blocking the effects of histamine, a substance released by the body during an allergic reaction. (ambicapharmacy.com)
- Q: Can Loratadine Tablets be used in children? (ambicapharmacy.com)
- Q: How are Loratadine Tablets taken? (ambicapharmacy.com)
- Loratadine tablets are typically taken orally with or without food. (ambicapharmacy.com)
- When taking nolvadex, patients experience decreased cravings for alcohol and drug use and buy loratadine tablets increased feelings of confidence and control. (dewysparkle.com)
Tablet5
- Loratadine comes as a syrup (liquid), a tablet, and a rapidly disintegrating (dissolving) tablet to take by mouth. (medlineplus.gov)
- Each Tablet contains 5 mg of loratadine. (citymarket.com)
- Adults and children 6 years of age and over: The recommended dose of CLARITIN (loratadine) is one 10 mg tablet or reditab, or 2 teaspoonfuls (10 mg) of syrup once daily. (novalarpharm.com)
- Loratadine Actavis is available in tablet form and is typically taken orally, with or without food. (allergostore.com)
- Atadyn Tablet is a non-drowsy loratadine tablet used for allergic rhinitis, nasal discharge and itching, ocular itching and burning and sneezing. (com.ng)
Allergies6
- Loratadine, sold under the brand name Claritin among others, is a medication used to treat allergies. (wikipedia.org)
- Loratadine is indicated for the symptomatic relief of allergy such as hay fever (allergic rhinitis), urticaria (hives), chronic idiopathic urticaria, and other skin allergies. (wikipedia.org)
- Loratadine is used to temporarily relieve the symptoms of hay fever (allergy to pollen, dust, or other substances in the air) and other allergies. (medlineplus.gov)
- Loratadine and pseudoephedrine is a combination medicine used to treat sneezing, runny or stuffy nose, sinus pain, itchy or watery eyes or nose, and other symptoms of allergies and the common cold. (cigna.com)
- Loratadine Actavis is a medication used to relieve symptoms associated with allergies, such as sneezing, runny or itchy nose, and itchy eyes. (allergostore.com)
- He is currently taking fluticasone and loratadine for seasonal allergies but is not using any eye drops. (medscape.com)
Clarityn2
- Fass environmental information for Clarityn (loratadine) from Bayer (downloaded 2019-11-28). (janusinfo.se)
- What is Loratadine/Clarityn? (pharmacyplanet.com)
Fexofenadine2
- there was no significant difference between loratadine and fexofenadine. (snackroots.com)
- History or evidence of allergy or hypersensitivity to Fexofenadine, Loratadine, Levocetirizine, Cetirizine, Hydroxyzine or any piperidine derivative drugs or any of the excipients of this product. (who.int)
Symptoms5
- For allergic rhinitis, loratadine is indicated for both nasal and eye symptoms - sneezing, runny nose, and itchy or burning eyes. (wikipedia.org)
- Telfast works exactly the same way as loratadine but, being prescription-only, might be more effective in treating severe hay fever symptoms. (lloydspharmacy.com)
- Loratadine blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial smooth muscle, and gastrointestinal smooth muscle, including vasodilatation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscle. (allergostore.com)
- By inhibiting histamine, loratadine helps reduce or alleviate allergy symptoms. (ambicapharmacy.com)
- Finally, it gets very itchy and you'll notice that the pimples, and the other signs cost of loratadine and symptoms of the skin disorder, aren't clearing up. (dewysparkle.com)
Active ingredients2
- Loratadine has active ingredients of loratadine . (ehealthme.com)
- It is based on loratadine (the active ingredients of Loratadine) and Loratadine (the brand name). (ehealthme.com)
Histamine1
- Loratadine is a piperidine histamine H1-receptor antagonist with anti-allergic properties and without sedative effects. (allergostore.com)
Pseudoephedrine9
- It is also available in combination with pseudoephedrine, a decongestant, known as loratadine/pseudoephedrine. (wikipedia.org)
- Loratadine is also available in combination with pseudoephedrine (Sudafed, others). (medlineplus.gov)
- If you are taking the loratadine and pseudoephedrine combination product, read the information on the package label or ask your doctor or pharmacist for more information. (medlineplus.gov)
- What is the most important information I should know about loratadine and pseudoephedrine? (cigna.com)
- Loratadine and pseudoephedrine may also be used for purposes not listed in this medication guide. (cigna.com)
- What should I discuss with my healthcare provider before taking loratadine and pseudoephedrine? (cigna.com)
- Do not use loratadine and pseudoephedrine if you have used an MAO inhibitor in the past 14 days. (cigna.com)
- How should I take loratadine and pseudoephedrine? (cigna.com)
- What should I avoid while taking loratadine and pseudoephedrine? (cigna.com)
Drowsiness5
- If you take more loratadine than directed, you may experience drowsiness. (medlineplus.gov)
- If loratadine is used with either of these medications, drowsiness may result. (vin.com)
- Common side effects of Loratadine Actavis include drowsiness, dry mouth, and headache. (allergostore.com)
- Loratadine is generally well-tolerated in dogs and cats, but occasional side effects such as drowsiness can occur. (northwestcompounders.com)
- Use loratadine mainly if drowsiness from Benadryl interferes with function. (childrenscolorado.org)
Cetirizine7
- Similarly to cetirizine, loratadine attenuates the itching associated with Kimura's disease. (wikipedia.org)
- Is loratadine and cetirizine the same thing? (snackroots.com)
- Is loratadine or cetirizine better? (snackroots.com)
- While patients have reported that cetirizine hydrochloride works faster, loratadine lasts longer. (snackroots.com)
- Can I take loratadine and cetirizine? (snackroots.com)
- No interactions were found between cetirizine and loratadine. (snackroots.com)
- Which is more sedating cetirizine or loratadine? (snackroots.com)
Take loratadine7
- Take loratadine exactly as directed. (medlineplus.gov)
- The phase IV clinical study analyzes which people take Loratadine and have Enterovesical fistula. (ehealthme.com)
- Do you take Loratadine and have Enterovesical fistula? (ehealthme.com)
- Can I take loratadine at night? (snackroots.com)
- Timing: Take loratadine once a day at the same time each day, either in the morning OR in the evening. (snackroots.com)
- You can take loratadine with or without food. (snackroots.com)
- Can I take loratadine 10 mg twice a day? (snackroots.com)
Medicine Loratadine1
- This medicine loratadine ritemed price is used to treat certain infections caused by bacteria, virus, fungus and parasites in your body. (dewysparkle.com)
Desloratadine1
- You should not take Claritin if you are allergic to loratadine or to desloratadine (Clarinex). (novalarpharm.com)
Medication4
- Loratadine is available as a generic medication. (wikipedia.org)
- Generic Loratadine is a medication which effectively resolves mild, moderate and severe allergic reactions. (mynetpharma.com)
- Drugs found to increase loratadine blood levels with concurrent use include ketoconazole (an anti-fungal medication), cimetidine (an antacid), and erythromycin (an antibiotic). (vin.com)
- Claritin is a common medication containing loratadine. (snackroots.com)
Hives5
- Loratadine is also used to treat itching and redness caused by hives. (medlineplus.gov)
- However, loratadine does not prevent hives or other allergic skin reactions. (medlineplus.gov)
- Do not use loratadine to treat hives that are bruised or blistered, that are an unusual color, or that do not itch. (medlineplus.gov)
- Stop taking loratadine and call your doctor if your hives do not improve during the first 3 days of your treatment or if your hives last longer than 6 weeks. (medlineplus.gov)
- Hives are also treated with loratadine to relieve itching and redness. (brixpharma.com)
Prescription2
- Being an over-the-counter treatment, a prescription isn't needed to obtain loratadine. (lloydspharmacy.com)
- Cheap Claritin 'Loratadine' Online No Prescription. (novalarpharm.com)
Syrup1
- Children 2 to 5 years of age: The recommended dose of CLARITIN (loratadine) Syrup is 5 mg (1 teaspoonful) once daily. (novalarpharm.com)
Allegra1
- Claritin , ( loratadine ) Allegra and zyrtec are relatively safe. (healthtap.com)
Drugs3
- With allergy drugs such as astemizole, how about claritin (loratadine)? (healthtap.com)
- With allergy drugs such as astemizole can I take claritin (loratadine)? (healthtap.com)
- Generic drugs come in a multitude of cost of loratadine forms, each designed to suit an individual's needs. (dewysparkle.com)
Ingredients1
- tell your doctor and pharmacist if you are allergic to loratadine, any other medications, or any of the ingredients in loratadine preparations. (medlineplus.gov)
Prescriptions2
- Buy Claritin 'Loratadine' Online Without Prescriptions. (novalarpharm.com)
- Order Claritin 'Loratadine' Online Without Prescriptions. (novalarpharm.com)
Dose1
- Substances that act as inhibitors of the CYP3A4 enzyme such as ketoconazole, erythromycin, cimetidine, and furanocoumarin derivatives (found in grapefruit) lead to increased plasma levels of loratadine - that is, more of the drug was present in the bloodstream than typical for a dose. (wikipedia.org)
Kimura's1
- Besides this, loratadine resolves the itching due to Kimura's disease. (mynetpharma.com)
Epinephrine1
- Do not use loratadine in place of the epinephrine injector. (medlineplus.gov)
Pregnant1
- If you become pregnant while taking loratadine, call your doctor. (medlineplus.gov)
Benadryl1
- Is loratadine the same as Benadryl? (snackroots.com)
Urticaria1
- Claritin es indicado para el alivio de los síntomas nasales y non-nasales de la rinitis alérgica estacional y para el tratamiento de la urticaria idiopática crónica en pacientes de 2 años o más. (alpiedelamuralla.org)
Generic4
- How to use Generic Loratadine? (mynetpharma.com)
- Generic Loratadine should be taken precisely as directed by the doctor after carefully reading the label instructions. (mynetpharma.com)
- If no symptom improvement is realized within a small number of days or symptom exacerbate after long term use of Generic Loratadine, call the doctor proximately. (mynetpharma.com)
- Generic Loratadine is not for use in children younger than 12 years of age. (mynetpharma.com)
Healthcare1
- It is important to follow the instructions of a healthcare professional when taking Loratadine Actavis. (allergostore.com)
Side6
- Side effects to loratadine are very rare and usually mild. (lloydspharmacy.com)
- If you experience these side effects, stop taking loratadine and consult a GP for alternate treatment. (lloydspharmacy.com)
- We study 50,414 people who have side effects when taking Loratadine. (ehealthme.com)
- 50,414 people reported to have side effects when taking Loratadine. (ehealthme.com)
- Limit drinking alcohol while you are taking loratadine: It may increase your chance of side effects such as sleepiness. (snackroots.com)
- Loratadine may cause side effects. (snackroots.com)
Populations1
- Among the 1,957 mothers of infants in the case and control populations, 33 (1.7%) reported using loratadine during the exposure period. (cdc.gov)
Treatments1
- Loratadine is one of a number of over the counter treatments for hay fever. (lloydspharmacy.com)