A beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle. Its vasodilating actions are greater on the arteries supplying skeletal muscle than on those supplying skin. It is used in the treatment of peripheral vascular disease and in premature labor.
A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide.
Illegitimate use of substances for a desired effect in competitive sports. It includes humans and animals.
Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.

Direct MS-MS identification of isoxsuprine-glucuronide in post-administration equine urine. (1/14)

Isoxsuprine is routinely recovered from enzymatically-hydrolyzed, post-administration urine samples as parent isoxsuprine in equine forensic science. However, the specific identity of the material in horse urine from which isoxsuprine is recovered has never been established, although it has long been assumed to be a glucuronide conjugate (or conjugates) of isoxsuprine. Using ESI/MS/MS positive mode as an analytical tool, urine samples collected 4-8 h after isoxsuprine administration yielded a major peak at m/z 554 that was absent from control samples and resisted fragmentation to daughter ions. Titration of this material with increasing concentrations of sodium acetate yielded m/z peaks consistent with the presence of monosodium and disodium isoxsuprine-glucuronide complexes, suggesting that the starting material was a dipotassium-isoxsuprine-glucuronide complex. Electrospray ionization mass spectrometry negative mode disclosed the presence of a m/z 476 peak that declined following enzymatic hydrolysis and resulted in the concomitant appearance of peaks at m/z 300 and 175. The resulting peaks were consistent with the presence of isoxsuprine (m/z 300) and a glucuronic acid residue (m/z 175). Examination of the daughter ion spectrum of this putative isoxsuprine-glucuronide m/z 476 peak showed overlap of many peaks with those of similar spectra of authentic morphine-3- and morphine-6-glucuronides, suggesting they were derived from glucuronic acid conjugation. These data suggest that isoxsuprine occurs in post-administration urine samples as an isoxsuprine-glucuronide conjugate and also, under some circumstances, as an isoxsuprine-glucuronide-dipotassium complex.  (+info)

A GC-MS method for the determination of isoxsuprine in biological fluids of the horse utilizing electron impact ionization. (2/14)

Isoxsuprine is used to treat navicular disease and other lower-limb problems in the horse. Isoxsuprine is regulated as a class 4 compound by the Association of Racing Commissioners, International (ARCI) and, thus, requires regulatory monitoring. A gas chromatography-mass spectrometry method utilizing electron impact ionization was developed and validated for the quantitation of isoxsuprine in equine plasma or equine urine. The method utilized robotic solid-phase extraction and tri-methyl silyl ether products of derivatization. Products were bis-trimethylsilyl (TMS) isoxsuprine and tris-TMS ritodrine, which released intense quantifier ions m/z 178 for isoxsuprine and m/z 236 for ritodrine that were products of C-C cleavage. To our knowledge, this procedure is faster and more sensitive than other methods in the literature. Concentrations in urine and plasma of isoxsuprine were determined from a calibrator curve that was generated along with unknowns. Ritodrine was used as an internal standard and was, therefore, present in all samples, standards, and blanks. Validation data was also collected. The limit of detection of isoxsuprine in plasma was determined to be 2 ng/mL, the limit of quantitation of isoxsuprine in plasma was determined to be < 5 ng/mL. The mean coefficient of determination for the calibrator curves for plasma was 0.9925 +/- 0.0052 and for calibrator curves for urine 0.9904 +/- 0.0075. The recovery efficiencies at concentrations of 50, 200, and 300 ng/mL were 76%, 73%, and 76%, respectively, in plasma and 92%, 89%, and 91% in urine.  (+info)

Desensitization of the beta-adrenoceptor of lymphocytes from normal subjects and patients with phaeochromocytoma: studies in vivo. (3/14)

1 Following the observation that lymphocyte beta-adrenoceptor responsiveness was not depressed in asthmatics treated only with non-adrenergic drugs we have explored the effects of prolonged exposure to beta-adrenoceptor agonists in normal subjects. 2 Treatment with oral salbutamol (12-16 mg/kg/day for 10 days), or with inhaled salbutamol (3000 microgram/day for 8-10 days) resulted in a significant reduction in lymphocyte beta-adrenoceptor responsiveness. 3 A 48 h infusion of isoxsuprine (10 mg/h) resulted in a marked depression of lymphocyte beta-adrenoceptor responsiveness (P less than 0.001). 4 Prolonged elevation of endogenous catecholamines caused by phaeochromocytoma was also associated with a marked depression of lymphocyte beta-adrenoceptor responsiveness (P less than 0.001). 5 There was no evidence that an increase in phosphodiesterase activity could explain the reduced cyclic AMP response. 6 It is concluded that diminished beta-adrenoceptor response occurs as a response to prolonged exposure to beta-adrenoceptor agonists. It is likely that the diminished response seen in asthmatic subjects can be explained on a similar basis and does not indicate an inherent cellular defect. 7 The possible clinical significance of such changes in asthmatics are discussed.  (+info)

In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen. (4/14)

 (+info)

Cold injuries in Kashmir, December 1971. (5/14)

A total of 847 cases of cold injury occurred within the short space of 2 weeks during the Indo-Pakistan conflict in Kashmir in December 1971. The management of these cases and their end results are described. A combination of drugs consisting of low-molecular-weight dextran, an anti-inflammatory agent, and a vasodilator was tried with encouraging results. A conservative attitude towards ablation of necrosed tissues paid good dividends.  (+info)

Increased red blood cell deformability due to isoxsuprine administration decreases platelet adherence in a perfusion chamber: a double-blind cross-over study in patients with intermittent claudication. (6/14)

Platelet transport towards the vessel wall is influenced by the hematocrit, red blood cell (RBC) size, and shape. Recent in vitro studies have indicated that RBC deformability may also influence platelet transport. The observation that isoxsuprine, a known vasodilating drug, caused increased RBC deformability in vitro and decreased platelet transport in vitro prompted us to study the effects of this drug in vivo. The study was performed in a double-blind cross-over study of isoxsuprine v placebo in ten patients with peripheral arterial insufficiency. RBC deformability was estimated from viscosity measurements using the blood viscosity equation of Dintenfass and expressed as T value. Platelet transport was studied in an annular perfusion chamber according to Baumgartner. Human umbilical arteries were used as blood vessels. Perfusion studies were performed with whole blood or with RBCs of the patients mixed with normal platelets and plasma at a standardized hematocrit and platelet count. An increase in RBC deformability concomitant with a decrease in platelet adherence was observed in patients on isoxsuprine with a drop in T value of approximately 0.06 (from 0.91 toward 0.86), and a concomitant decrease in platelet adherence of 20% to 40%. These observations differed significantly from the results in the placebo group and showed a significant group-period interaction at the cross-over of medication (analysis of variance). The effects on platelet adherence were observed at high vessel wall shear rate (1,800 s-1) with perfusates consisting of patients' RBCs and donor plasma and platelets at standardized hematocrit and platelet count. No differences were observed under these conditions at a shear rate of 300 s-1. When whole blood of patients was used, nonsignificant effect was observed at shear rates of 300 s-1 and 1,800 s-1. This was probably caused by the added noise due to variations in hematocrit and platelet number. These data demonstrate that isoxsuprine increases RBC deformability, and they suggest the possibility of decreasing platelet-vessel wall interaction in vivo by manipulation of RBC deformability.  (+info)

Premature labour. (7/14)

Prematurity is by far the commonest cause of neonatal morbidity and mortality. The management of premature labour is empirical because little is understood about the mechanism of labour. Effective uterine relaxant drugs have an important, albeit minor role. Phototherapy has reduced the complications of neonatal hyperbilirubinemia, and the beneficial effect of antepartum corticosteroid therapy in minimizing the risk of respiratory distress syndrome is now convincing. Prophylactic antibiotic therapy in premature rupture of the membranes does not alter perinatal mortality, although postpartum maternal morbidity is reduced. The introduction of neonatal intensive care units has improved the survival rate of premature infants. Sound clinical judgement remains the mainstay in the management of premature labour.  (+info)

Isoxsuprine as an oral vasodilator. (8/14)

The effect of isoxsuprine, administered orally as a single 20-mg tablet, was compared with that of a placebo in a double-blind crossover study in 12 volunteers with and in 12 without peripheral vascular disease. Isoxsuprine failed to increase blood flow in the calf, foot or hand, and did not alter blood pressure or heart rate significantly. Claudication time was not prolonged after taking the drug. This study does not support the value of oral administration of isoxsuprine as a peripheral vasodilator.  (+info)

Isoxsuprine is a medication that belongs to a class of drugs known as vasodilators. It works by relaxing and widening the blood vessels, which improves the flow of blood and oxygen to the heart. Isoxsuprine is primarily used in the treatment of chronic foot pain (vasospastic disorders) associated with peripheral vascular disease, such as Raynaud's phenomenon or intermittent claudication.

The medical definition of Isoxsuprine can be stated as:

A synthetic imidazolidinone derivative and a selective beta-2 adrenergic receptor agonist, used in the form of its hydrochloride salt (Isoxsuprine HCl) for the treatment of chronic foot pain caused by peripheral vascular disorders. Isoxsuprine acts as a vasodilator, relaxing and widening blood vessels, thereby enhancing blood flow and oxygen supply to the heart. It is also used off-label in some cases to manage premature labor due to its ability to relax uterine smooth muscle.

Acetohexamide is a first-generation sulfonylurea oral hypoglycemic medication that is used in the management of type 2 diabetes. It works by stimulating the release of insulin from the pancreas and increasing insulin sensitivity in peripheral tissues, thereby lowering blood glucose levels.

The chemical name for Acetohexamide is N-(2-Hydroxyethyl)-1-((p-tbutylphenyl)sulfonyl)urea, and it has a molecular formula of C13H19N2O4S. It is available in various forms, including tablets, for oral administration.

Acetohexamide is typically prescribed when diet and exercise have failed to control blood sugar levels effectively. Like other sulfonylureas, it carries a risk of hypoglycemia (low blood sugar) as a side effect, particularly in elderly patients or those with impaired kidney function. Therefore, it is essential to monitor blood glucose levels regularly while taking this medication and adjust the dosage accordingly.

It's important to note that Acetohexamide should be used under the supervision of a healthcare provider, and patients should follow their doctor's instructions carefully when taking this medication.

Doping in sports is the use of prohibited substances or methods to improve athletic performance. The World Anti-Doping Agency (WADA) defines doping as "the occurrence of one or more of the following anti-doping rule violations":

1. Presence of a prohibited substance in an athlete's sample
2. Use or attempted use of a prohibited substance or method
3. Evading, refusing, or failing to submit to sample collection
4. Whereabouts failures (three missed tests or filing failures within a 12-month period)
5. Tampering or attempted tampering with any part of the doping control process
6. Possession, trafficking, or administration of a prohibited substance or method
7. Complicity in an anti-doping rule violation
8. Prohibited association with a person who has been serving a period of ineligibility for an anti-doping rule violation

Doping is considered unethical and harmful to the integrity of sports, as it provides an unfair advantage to those who engage in it. It can also have serious health consequences for athletes. Various international and national organizations, including WADA and the United States Anti-Doping Agency (USADA), work to prevent doping in sports through education, testing, and enforcement of anti-doping rules.

Sympatholytics are a class of drugs that block the action of the sympathetic nervous system, which is the part of the autonomic nervous system responsible for preparing the body for the "fight or flight" response. Sympatholytics achieve this effect by binding to and blocking alpha-adrenergic receptors or beta-adrenergic receptors located in various organs throughout the body, including the heart, blood vessels, lungs, gastrointestinal tract, and urinary system.

Examples of sympatholytic drugs include:

* Alpha blockers (e.g., prazosin, doxazosin)
* Beta blockers (e.g., propranolol, metoprolol)
* Centrally acting sympatholytics (e.g., clonidine, methyldopa)

Sympatholytics are used to treat a variety of medical conditions, including hypertension, angina, heart failure, arrhythmias, and certain neurological disorders. They may also be used to manage symptoms associated with anxiety or withdrawal from alcohol or other substances.

... is given orally, and many horses find the pills quite palatable. Isoxsuprine is a prohibited class B drug in FEI- ... Isoxsuprine (used as isoxsuprine hydrochloride) is a drug used as a vasodilator in humans (under the trade name Duvadilan) and ... Isoxsuprine is used in humans for treatment of premature labor, i.e. a tocolytic, and as a vasodilator for the treatment of ... Isoxsuprine may increase the heart rate, cause changes in blood pressure, and irritate the GI tract. It should therefore be ...
Isoxsuprine and pentoxifylline are two commonly used vasodilators in equine medicine. Isoxsuprine has been shown to have ... Isoxsuprine hydrochloride in the horse: a review. J Vet Pharmacol Ther. 2002 Apr;25(2):81-7. Liska, Dana A., et al. " ... The lack of efficacy of isoxsuprine may be partially due to its poor oral bioavailability (2.2%) and high first pass effect. ... The effect of oral isoxsuprine and pentoxifylline on digital and laminar blood flow in healthy horses. Vet. Surg. 1999; 28(3): ...
Examples include isoxsuprine (currently unavailable in the UK) and pentoxifylline. Anticoagulants can also improve blood flow. ...
Isoxsuprine Mittag TW, Tormay A, Messenger M, Podos SM (February 1985). "Ocular hypotension in the rabbit. Receptor mechanisms ...
1997). "Effects of acepromazine maleate, isoxsuprine hydrochloride and prazosin hydrochloride on laminar blood flow in healthy ...
Befunolol Bromoacetylalprenololmenthane Broxaterol Cimaterol Cirazoline Etilefrine Hexoprenaline Higenamine Isoxsuprine ...
C04AA01 Isoxsuprine C04AA02 Buphenine C04AA31 Bamethan C04AB01 Phentolamine C04AB02 Tolazoline C04AC01 Nicotinic acid C04AC02 ...
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Prashant Pawar, Amol Pawar, "Nifedipineversus Isoxsuprine for Suppression of Preterm Labour - A Comparative Randomised Study", ... Nifedipineversus Isoxsuprine for Suppression of Preterm Labour - A Comparative Randomised Study. Prashant Pawar , Amol Pawar ... Objectives - To compare the efficacy of Nifedipine and Isoxsuprine with respect to Days of gestation gained by tocolysis ... This study was undertaken to compare the efficacy of Nifedipine and Isoxsuprine for suppression of preterm labour. ...
SIDE EFFECTS. All medicines may cause side effects, but many people have no, or minor, side effects.. When used in small doses, no common side effects have been reported with this product.. Seek medical attention right away if any of these severe side effects occur:. Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fast or irregular heartbeat; severe or persistent dizziness.. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. ...
Isoxsuprine Hydrochloride. Catalog No: Product Name: Isoxsuprine Hydrochloride. CAS No:579-56-6,,Chemical Formula:C18H24ClNO3 ...
Isoxsuprine. 0.05%. Pyrantel. 0.03%. N-[3-(Trifluoromethyl)phenyl]piperazine. 0.03%. Imipramine. 0.02%. ...
Vasodilan®see Isoxsuprine. *Vasotec®see Enalapril. *Vaxchora®see Cholera Vaccine. *Vaxneuvance®see Pneumococcal Conjugate ...
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Use of isoxsuprine hydrochloride as a tocolytic agent in the treatment of preterm labour: a systematic review of previous ...
Weve ordered some isoxsuprine for him to start and also bute 3 days per week, as well as theraputic shoeing. I just ran across ...
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  • Isoxsuprine (used as isoxsuprine hydrochloride) is a drug used as a vasodilator in humans (under the trade name Duvadilan) and equines. (wikipedia.org)
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  • However, your response is inadequate because it failed to include a retrospective review of (b)(4)/(b)(4) USP, (b)(4)/(b)(4) mg tablets, and isoxsuprine hydrochloride USP, 20 mg tablets, manufactured for the US market on equipment identified above," FDA stated in the letter. (biopharminternational.com)
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  • When your horse is diagnosed with navicular syndrome by your veterinarian a common drug therapy will normally include isoxsuprine hydrochloride, a drug which causes dilation of the small blood vessels. (hoof-it.com)
  • Vasodilan es utilizado para mejorar el flujo sanguíneo en ciertas condiciones (por ejemplo, insuficiencia vascular cerebral, la arteriosclerosis obliterante, enfermedad de Buerger, enfermedad de Raynaud). (metodosanticonceptivos.online)
  • Isoxsuprine is a β2 adrenoreceptor agonist that causes direct relaxation of uterine and vascular smooth muscle via β2 receptors. (wikipedia.org)
  • Isoxsuprine relaxes the uterine smooth muscles and is used for treatment of pre-term labor and dysmenorrhea. (arlakcorazon.co.in)
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  • The prolongation of pregnancy up to 37 weeks was 23 (46 %) and 13 (26 %) in Nifedipine and Isoxsuprine group respectively.19 (38 %) patients in Nifedipine group had side effects as compared to 42 (84 %) in Isoxsuprine group. (ijsr.net)
  • Isoxsuprine is used in humans for treatment of premature labor, i.e. a tocolytic, and as a vasodilator for the treatment of cerebral vascular insufficiency, Raynaud's phenomenon, and other conditions. (wikipedia.org)
  • Isoxsuprine is most commonly used to treat hoof-related problems in the horse, most commonly for laminitis and navicular disease, as its effects as a vasodilator are thought to increase circulation within the hoof to help counteract the problems associated with these conditions. (wikipedia.org)
  • Manchester United may have to put their pursuit of Jadon Sancho off isoxsuprine until next year as they are unwilling to meet the asking price, according to The Mirror. (ziptango.com)
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  • Products from these mills can be used in this isoxsuprine chapter. (auxerretv.com)
  • Isoxsuprine is given orally, and many horses find the pills quite palatable. (wikipedia.org)
  • 9.17 shows the CP-MAS spectrum of applicability isoxsuprine but each of these standards. (auxerretv.com)
  • Isoxsuprine (used as isoxsuprine hydrochloride) is a drug used as a vasodilator in humans (under the trade name Duvadilan) and equines. (wikipedia.org)
  • Buy Duvadilan 10mg (Isoxsuprine), Isoxsuprine is in a class of drugs called vasodilators. (alldaygeneric.com)
  • Duvadilan Retards is in the FDA pregnancy category C. This means that it is not known whether isoxsuprine will be harmful to an unborn baby. (alldaygeneric.com)
  • Take isoxsuprine exactly as directed. (medlineplus.gov)
  • Older adults should not usually take isoxsuprine because it is not as safe and effective as other medications that can be used to treat the same condition. (medlineplus.gov)
  • How should I take isoxsuprine? (alldaygeneric.com)
  • It is important to take isoxsuprine regularly to get the most benefit. (alldaygeneric.com)
  • Isoxsuprine is a β2 adrenoreceptor agonist that causes direct relaxation of uterine and vascular smooth muscle via β2 receptors. (wikipedia.org)
  • Isoxsuprine is a beta adrenoceptor agonist with selectivity of action for the smooth muscles of the blood vessels, particularly the cerebral vessels and the deeper vessels of the limbs. (jairadhesales.co.in)
  • Isoxsuprine is a β2 adrenoreceptor agonist and can be used as a vasodilator in humans and. (bocsci.com)
  • tell your doctor and pharmacist if you are allergic to isoxsuprine, any other medications, or any of the ingredients in isoxsuprine tablets. (medlineplus.gov)
  • Isoxsuprine is used in humans for treatment of premature labor, i.e. a tocolytic, and as a vasodilator for the treatment of cerebral vascular insufficiency, Raynaud's phenomenon, and other conditions. (wikipedia.org)
  • Isoxsuprine is used to relieve the symptoms of central and peripheral vascular diseases such as arteriosclerosis, Buerger's disease, and Raynaud's disease. (medlineplus.gov)
  • If you become pregnant while taking isoxsuprine, call your doctor. (medlineplus.gov)
  • Dear sir, please advice me the oral dose rate of isoxsuprine for equine laminitis and also how long i have to administer. (medschat.com)
  • Isoxsuprine is given orally, and many horses find the pills quite palatable. (wikipedia.org)
  • Alternatively, you can ask the pharmacist to recommend good options for the Isoxsuprine generic medicine (which is what iscom essentially is). (medicineindia.org)
  • Do not drive a car or operate machinery until you know how isoxsuprine will affect you. (medlineplus.gov)
  • Isoxsuprine may cause side effects. (medlineplus.gov)
  • Your doctor may want you to have blood tests or other medical evaluations during treatment with isoxsuprine to monitor progress and side effects. (alldaygeneric.com)
  • Separation of the isoxsuprine chiral selectors that would still have good recovery? (hotpod.net.au)
  • Store isoxsuprine at room temperature away from moisture and heat. (alldaygeneric.com)
  • talk to your doctor about the risks and benefits of taking isoxsuprine if you are 65 years of age or older. (medlineplus.gov)
  • Isoxsuprine is a prohibited class B drug in FEI-regulated competition, and is often prohibited by other equine associations. (wikipedia.org)
  • Isoxsuprine relaxes veins and arteries, which makes them wider and allows blood to pass through them more easily. (alldaygeneric.com)