The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.
Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
Compounds with two BENZENE rings fused to AZEPINES.
A bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use.
A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
Involuntary discharge of URINE after expected age of completed development of urinary control. This can happen during the daytime (DIURNAL ENURESIS) while one is awake or during sleep (NOCTURNAL ENURESIS). Enuresis can be in children or in adults (as persistent primary enuresis and secondary adult-onset enuresis).
A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
A thioxanthine with effects similar to the phenothiazine antipsychotics.
Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
A selective serotonin reuptake inhibitor that is used in the treatment of DEPRESSION and a variety of ANXIETY DISORDERS.
An activity in which the body is propelled through water by specific movement of the arms and/or the legs. Swimming as propulsion through water by the movement of limbs, tail, or fins of animals is often studied as a form of PHYSICAL EXERTION or endurance.
An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)
The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
Genus of perennial plants in the family CLUSIACEAE (sometimes classified as Hypericaceae). Herbal and homeopathic preparations are used for depression, neuralgias, and a variety of other conditions. Hypericum contains flavonoids; GLYCOSIDES; mucilage, TANNINS; volatile oils (OILS, ESSENTIAL), hypericin and hyperforin.
A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
A phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.
A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
Tricyclic antidepressant similar to IMIPRAMINE, but with more antihistaminic and sedative properties.
A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytocic and an anti-arrhythmia agent. It has also been of interest as an indicator of CYP2D6 genotype.
Antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects.
An anticonvulsant effective in tonic-clonic epilepsy (EPILEPSY, TONIC-CLONIC). It may cause blood dyscrasias.
A serotonin uptake inhibitor that is effective in the treatment of depression.

Effect of psychotropic drugs on caudate spindle in cats. (1/556)

To ascertain whether neuroleptics act on the caudate nucleus itself, the effects of these compounds as well as other centrally acting drugs were examined in relation to caudate spindle and EEG arousal responses (sciatic nerve stimulation) in gallamine-immobilized cats. Haloperidol and chlorpromazine enhanced the caudate spindle at a dose which had no effect on the EEG arousal response. On the other hand, clozapine and a higher dose of chlorpromazine enhanced the caudate spindle, but depressed the arousal response. High frequency stimulation of the sciatic nerve suppressed the caudate spindle. Pentobarbital, biperiden and diazepam, while depressing the arousal response, caused an enhancement of the caudate spindle. Imipramine at a low dose had no effect on either response, whereas at a high dose this drug enhanced the caudate spindle with concomitant depression of the arousal response. From these results, it may be concluded that the enhancing action on the caudate spindle induced by haloperidol and a low dose of chlorpromazine is due to an increase in susceptibility of the caudate nucleus itself. In addition, it is suggested that depression of the activating system is involved in an appearance of the caudate spindle.  (+info)

Imipramine blocks the transient outward potassium current in rat ventricular myocytes. (2/556)

AIM: To examine the effects of imipramine on transient outward potassium current (I(to) in rat ventricular myocytes. METHODS: The patch-clamp whole-cell recording techniques were used. RESULTS: Imipramine resulted in a concentration-dependent inhibition of I(to) with the IC50 of 6.0 mumol.L-1 and a concentration-dependent acceleration of I(to) inactivation. The blocking showed no difference at different testing membrane potentials. Imipramine produced slight effects (about 3 and 4 mV, respectively) on steady-state activation and inactivation curves of I(to), and tended to prolong the recovery of I(to) from inactivation (tau control = 37 +/- 11 ms; tau drug = 58 +/- 17 ms), but not significant (n = 4, P > 0.05). The inhibitory effect of imipramine on Ito was increased when the prepulses were prolonged progressively from 0 to 120 ms. (tau control = 22 +/- 8 ms; tau drug = 14 +/- 5 ms). CONCLUSIONS: Imipramine blocked Ito in concentration-dependent but voltage-independent manners, and with "open channel blocking" properties.  (+info)

Antagonistic effects of trifluoperazine, imipramine, and chlorpromazine against acetylcholine-induced contractions in isolated rat uterus. (3/556)

AIM: To examine the effects and affinity of some phenothizines (trifluoperazine, Tri and chlorpromazine, Chl) and antidepressant (imipramine, Imi) drugs on acetylcholine (ACh)-induced uterine contraction. METHODS: Isotonic contractions of rat uterine strips were recorded. ACh was administrated to induce maximal contraction before exchange of nutrient solution. ACh was added 5 min after the testing drugs. The nutrient solution was exchanged 4 times after each agonist (ACh or other agents) to produce maximal contraction. RESULTS: Atropine (Atr, 0.029-2.9 mumol.L-1), 4-DAMP (3.6-360 nmol.L-1), pirenzepine (Pir, 0.23-23.5 mumol.L-1), and AF-DX 116 (0.7-35.6 mumol.L-1) competitively antagonized the muscular uterine concentration induced by ACh (0.068-36068 mumol.L-1). The Schild plot was linear (r = 1.00). The pKB and slopes values (95% confidence limits) were 9.28 +/- 0.12 and 1.00 +/- 0.10 to Atr, 9.06 +/- 0.10 and 1.10 +/- 0.08 to 4-DAMP, 7.03 +/- 0.15 and 0.99 +/- 0.12 to Pir, and 5.60 +/- 0.08 and 1.00 +/- 0.19 to AF-DX 116. Tri 0.01-2 mumol.L-1 (pKB = 8.39 +/- 0.04) and Imi 94-940 nmol.L-1 (pKB = 7.21 +/- 0.10) produced also a competitive antagonism of the muscular uterine contraction induced by ACh (r = 1.00), but the slope was only 0.60 +/- 0.03 to Tri or 0.83 +/- 0.16 to Imi. Chl 2.8-5.6 mumol.L-1 produced a weak antagonism on amplitude of muscular contraction induced by the cholinomimetic. CONCLUSION: The muscarinic receptors on uterus behaved as M3 subtype. Tri and Imi, but not Chl, were competitive antagonist of muscarinic receptors of uterus. Imi behaved a simple competitive antagonist at a single site on myometrium, but Tri was not a simple competitive agent at a single site.  (+info)

Studies on the uptake, metabolism, and release of endogenous and exogenous chemicals by use of the isolated perfused lung. (4/556)

The isolated perfused lung is a valuable tool for studying many lung functions. The kinds of information one can obtain from the isolated perfused lung are illustrated by examples from our studies on the uptake, accumulation, and metabolism of endogenous and exogenous chemicals.  (+info)

Fas/CD95/Apo-I activates the acidic sphingomyelinase via caspases. (5/556)

Fas/CD95/Apo-I has been shown to stimulate a variety of molecules including several members of the caspase family and the acidic sphingomyelinase (Martin and Green 1995; Gulbins et al, 1995). Here, we demonstrate that Fas receptor-triggered activation of the acidic sphingomyelinase, consumption of sphingomyelin, release of ceramide, and subsequent activation of JNK and p38-K are regulated by caspases. Inhibition of caspases by Ac-YVAD-chloromethylketone or transient CrmA transfection prevented stimulation of acidic sphingomyelinase, release of ceramide and activation of JNK and p38-K upon Fas-receptor crosslinking. Likewise, Fas triggered apoptosis was almost completely blocked by Ac-YVAD-chloromethylketone or CrmA mediated inhibition of caspases. The results suggest a new signalling cascade from the Fas receptor via caspases to acidic sphingomyelinase, ceramide and JNK/p38-K.  (+info)

Depressive state with anxiety in repeated cold-stressed mice in forced swimming tests. (6/556)

The effects of various types of stress and drugs were studied to assess mouse performance in forced swimming tests, following characterization of SART (specific alternation of rhythm in environmental temperature) stress. Immobility time in the test decreased in mice subjected to SART, acute cold and restraint stress. No change was noted due to chronic cold stress or repeated fasting. The shortened time did not recover even 24 hr after the end of SART and chronic restraint stress. The time in SART-stressed mice finally recovered at 5-7 days. Shortening of immobility time in SART-stressed mice was inhibited by diazepam and repeated imipramine but not by lithium carbonate. In chronic restraint-stressed mice, this time was inhibited by repeated lithium carbonate but not diazepam or imipramine. SART stress would thus appear related to anxiety and depression and may be useful for detecting new types of antidepressants.  (+info)

Effects of imipramine, an uptake inhibitor, on double-peaked constrictor responses to periarterial nerve stimulation in isolated, perfused canine splenic arteries. (7/556)

Using a cannula insertion method, periarterial nerve electrical stimulations were performed at 1 and 10 Hz in the isolated, perfused canine splenic artery. Electrical nerve stimulation readily caused double-peaked vasoconstrictions. The 1st-peak response at 1 Hz was not influenced by treatment with imipramine but the 2nd one was significantly enhanced by it. The 2nd-peak response was markedly blocked by prazosin. An additional treatment with alpha,beta-methylene ATP, a P2X-purinoceptor desensitizer, abolished electrical stimulation-induced vascular responses that remained. At 10 Hz, the responses to electrical stimulation were not significantly influenced by imipramine. On the other hand, the imipramine treatment inhibited the tyramine-induced vasoconstriction but potentiated the noradrenaline-induced one. ATP-induced responses were not modified by imipramine. From these results, it is concluded that 1) the 1st-peaked constriction is mainly due to a P2X-purinoceptor-dependent mechanism, 2) the 2nd one is mainly due to an alpha1-adrenoceptor-dependent mechanism, and 3) presynaptic uptake mechanisms may perform an important role in the regulation of vascular reactivity, especially at a low frequency.  (+info)

Transmembrane domain I contributes to the permeation pathway for serotonin and ions in the serotonin transporter. (8/556)

Mutation of a conserved Asp (D98) in the rat serotonin (5HT) transporter (rSERT) to Glu (D98E) led to decreased 5HT transport capacity, diminished coupling to extracellular Na+ and Cl-, and a selective loss of antagonist potencies (cocaine, imipramine, and citalopram but not paroxetine or mazindol) with no change in 5HT Km value. D98E, which extends the acidic side chain by one carbon, affected the rank-order potency of substrate analogs for inhibition of 5HT transport, selectively increasing the potency of two analogs with shorter alkylamine side chains, gramine, and dihydroxybenzylamine. D98E also increased the efficacy of gramine relative to 5HT for inducing substrate-activated currents in Xenopus laevis oocytes, but these currents were noticeably dependent on extracellular medium acidification. I-V profiles for substrate-independent and -dependent currents indicated that the mutation selectively impacts ion permeation coupled to 5HT occupancy. The ability of the D98E mutant to modulate selective aspects of substrate recognition, to perturb ion dependence as well as modify substrate-induced currents, suggests that transmembrane domain I plays a critical role in defining the permeation pathway of biogenic amine transporters.  (+info)

Imipramine is a tricyclic antidepressant (TCA) medication that is primarily used to treat depression. It works by increasing the levels of certain neurotransmitters, such as serotonin and norepinephrine, in the brain. Imipramine has been found to be effective in treating various types of depression, including major depressive disorder, dysthymia, and depression that is resistant to other treatments.

In addition to its antidepressant effects, imipramine is also used off-label for the treatment of several other conditions, such as anxiety disorders, attention deficit hyperactivity disorder (ADHD), enuresis (bedwetting), and chronic pain.

Imipramine was first synthesized in the 1950s and has been widely used since then. It is available in various forms, including immediate-release tablets, extended-release capsules, and liquid solutions. As with all medications, imipramine can have side effects, which may include dry mouth, blurred vision, constipation, dizziness, and sedation. In rare cases, it can cause more serious side effects, such as cardiac arrhythmias or seizures.

It is important to use imipramine under the close supervision of a healthcare provider, as dosages may need to be adjusted based on individual patient needs and responses to treatment. Additionally, imipramine should not be stopped abruptly, as doing so can lead to withdrawal symptoms or a recurrence of depression.

Tricyclic antidepressants (TCAs) are a class of medications that were commonly used to treat depression. The name "tricyclic" comes from the chemical structure of these drugs, which contain three rings in their molecular makeup. TCAs were first developed in the 1950s and remained a popular choice for treating depression until the introduction of selective serotonin reuptake inhibitors (SSRIs) in the late 1980s.

TCAs work by increasing the levels of neurotransmitters, such as serotonin and norepinephrine, in the brain. Neurotransmitters are chemical messengers that transmit signals between nerve cells. By increasing the levels of these neurotransmitters, TCAs can help to improve mood and alleviate symptoms of depression.

Some common examples of tricyclic antidepressants include amitriptyline, imipramine, and nortriptyline. While TCAs are effective in treating depression, they can have significant side effects, including dry mouth, blurred vision, constipation, and drowsiness. In addition, TCAs can be dangerous in overdose and may increase the risk of suicide in some individuals. As a result, they are typically used as a last resort when other treatments have failed.

Overall, tricyclic antidepressants are a class of medications that were commonly used to treat depression but have largely been replaced by newer drugs due to their side effects and potential risks.

Amitriptyline is a type of medication known as a tricyclic antidepressant (TCA). It is primarily used to treat depression, but it also has other therapeutic uses such as managing chronic pain, migraine prevention, and treating anxiety disorders. Amitriptyline works by increasing the levels of certain neurotransmitters (chemical messengers) in the brain, such as serotonin and norepinephrine, which help to regulate mood and alleviate pain.

The medication is available in various forms, including tablets and liquid solutions, and it is typically taken orally. The dosage of amitriptyline may vary depending on the individual's age, medical condition, and response to treatment. It is essential to follow the prescribing physician's instructions carefully when taking this medication.

Common side effects of amitriptyline include drowsiness, dry mouth, blurred vision, constipation, and weight gain. In some cases, it may cause more severe side effects such as orthostatic hypotension (low blood pressure upon standing), cardiac arrhythmias, and seizures. It is crucial to inform the healthcare provider of any pre-existing medical conditions or current medications before starting amitriptyline therapy, as these factors can influence its safety and efficacy.

Amitriptyline has a well-established history in clinical practice, but it may not be suitable for everyone due to its potential side effects and drug interactions. Therefore, it is essential to consult with a healthcare professional before using this medication.

Desipramine is a tricyclic antidepressant (TCA) that is primarily used to treat depression. It works by increasing the levels of certain neurotransmitters, such as norepinephrine and serotonin, in the brain. These neurotransmitters are important for maintaining mood, emotion, and behavior.

Desipramine is also sometimes used off-label to treat other conditions, such as anxiety disorders, chronic pain, and attention deficit hyperactivity disorder (ADHD). It is available in oral form and is typically taken one to three times a day.

Like all medications, desipramine can cause side effects, which can include dry mouth, blurred vision, constipation, dizziness, and drowsiness. More serious side effects are rare but can include heart rhythm problems, seizures, and increased suicidal thoughts or behavior in some people, particularly children and adolescents.

It is important to take desipramine exactly as prescribed by a healthcare provider and to report any bothersome or unusual symptoms promptly. Regular follow-up appointments with a healthcare provider are also recommended to monitor the effectiveness and safety of the medication.

Antidepressive agents are a class of medications used to treat various forms of depression and anxiety disorders. They act on neurotransmitters, the chemical messengers in the brain, to restore the balance that has been disrupted by mental illness. The most commonly prescribed types of antidepressants include selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), and monoamine oxidase inhibitors (MAOIs). These medications can help alleviate symptoms such as low mood, loss of interest in activities, changes in appetite and sleep patterns, fatigue, difficulty concentrating, and thoughts of death or suicide. It is important to note that antidepressants may take several weeks to reach their full effectiveness and may cause side effects, so it is essential to work closely with a healthcare provider to find the right medication and dosage.

Dibenzazepines are a class of chemical compounds that contain a dibenzazepine structure, which is a fusion of a benzene ring with a diazepine ring. Dibenzazepines have a wide range of pharmacological activities and are used in the treatment of various medical conditions.

Some of the medically relevant dibenzazepines include:

1. Antipsychotics: Some antipsychotic drugs, such as clozapine and olanzapine, have a dibenzazepine structure. These drugs are used to treat schizophrenia and other psychotic disorders.
2. Antidepressants: Mianserin and mirtazapine are dibenzazepine antidepressants that work by blocking the uptake of serotonin and noradrenaline in the brain. They are used to treat depression, anxiety, and insomnia.
3. Anticonvulsants: Some anticonvulsant drugs, such as levetiracetam and brivaracetam, have a dibenzazepine structure. These drugs are used to treat epilepsy and other seizure disorders.
4. Anxiolytics: Prazepam is a benzodiazepine derivative with a dibenzazepine structure that is used to treat anxiety disorders.
5. Analgesics: Tramadol is a centrally acting analgesic with a dibenzazepine structure that is used to treat moderate to severe pain.

It's important to note that while these drugs have a dibenzazepine structure, they may also contain other functional groups and have different mechanisms of action. Therefore, it's essential to consider the specific pharmacological properties of each drug when prescribing or administering them.

Maprotiline is a tetracyclic antidepressant (TCA) medication that is primarily used to treat major depressive disorder. It works by increasing the levels of neurotransmitters, such as norepinephrine and serotonin, in the brain, which can help to improve mood and alleviate symptoms of depression.

Maprotiline has a unique chemical structure that distinguishes it from other antidepressants, including selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs). It is considered to be a second-line treatment option for depression, typically reserved for use when other antidepressants have not been effective.

Like other TCAs, maprotiline can cause a range of side effects, including dry mouth, blurred vision, constipation, and dizziness. It may also cause more serious side effects, such as seizures, irregular heartbeat, and changes in blood pressure. As a result, it is important to use maprotiline under the close supervision of a healthcare provider.

Maprotiline is available in tablet form and is typically taken two to four times per day, with or without food. The dosage may be gradually increased over time to achieve the desired therapeutic effect. It may take several weeks of treatment before the full benefits of maprotiline are felt.

Mianserin is a tetracyclic antidepressant (TCA) that is primarily used to treat major depressive disorders. It functions by inhibiting the reuptake of neurotransmitters such as serotonin and noradrenaline, thereby increasing their availability in the brain and helping to alleviate symptoms of depression.

Mianserin also has additional properties, including antihistamine and anti-cholinergic effects, which can help reduce some side effects commonly associated with other antidepressants, such as insomnia and agitation. However, these same properties can also lead to side effects such as drowsiness, dry mouth, and orthostatic hypotension (a drop in blood pressure upon standing).

It's important to note that mianserin is not commonly prescribed due to its narrow therapeutic index and the risk of serious side effects, including agranulocytosis (a severe decrease in white blood cells), which can increase the risk of infection. As with any medication, it should only be taken under the close supervision of a healthcare provider.

Chlorpromazine is a type of antipsychotic medication, also known as a phenothiazine. It works by blocking dopamine receptors in the brain, which helps to reduce the symptoms of psychosis such as hallucinations, delusions, and disordered thinking. Chlorpromazine is used to treat various mental health conditions including schizophrenia, bipolar disorder, and severe behavioral problems in children. It may also be used for the short-term management of severe anxiety or agitation, and to control nausea and vomiting.

Like all medications, chlorpromazine can have side effects, which can include drowsiness, dry mouth, blurred vision, constipation, weight gain, and sexual dysfunction. More serious side effects may include neurological symptoms such as tremors, rigidity, or abnormal movements, as well as cardiovascular problems such as low blood pressure or irregular heart rhythms. It is important for patients to be monitored closely by their healthcare provider while taking chlorpromazine, and to report any unusual symptoms or side effects promptly.

Enuresis is a medical term that refers to the involuntary or unconscious release of urine, especially at night during sleep, in children who are at least 5 years old. It's commonly known as bedwetting. Enuresis can be classified into two types: primary and secondary. Primary enuresis occurs when a child has never achieved consistent dryness during sleep, while secondary enuresis happens when a child starts wetting the bed again after having been dry for at least six months.

Enuresis can have various causes, including developmental delays, small bladder capacity, urinary tract infections, constipation, sleep disorders, and emotional stress. In some cases, it may also be associated with genetic factors. Treatment options depend on the underlying cause and may include behavioral interventions, bladder training, alarm systems, medication, or a combination of these approaches.

Clomipramine is a tricyclic antidepressant drug that is primarily used to treat obsessive-compulsive disorder (OCD). It works by increasing the levels of certain neurotransmitters, such as serotonin and norepinephrine, in the brain. These neurotransmitters are involved in regulating mood and behavior.

Clomipramine is also used off-label to treat other conditions, including panic disorder, depression, chronic pain, and sleep disorders. It is available as a tablet or capsule and is typically taken one to three times a day. Common side effects of clomipramine include dry mouth, constipation, blurred vision, dizziness, and drowsiness.

As with all medications, clomipramine should be used under the close supervision of a healthcare provider, who can monitor its effectiveness and potential side effects. It is important to follow the dosage instructions carefully and to report any unusual symptoms or concerns to the healthcare provider promptly.

Chlorprothixene is a type of antipsychotic medication that is primarily used to treat chronic schizophrenia and related psychotic disorders. It belongs to a class of drugs known as phenothiazines, which work by blocking dopamine receptors in the brain. This helps to reduce the symptoms of psychosis, such as hallucinations, delusions, and disordered thinking.

Chlorprothixene is available in tablet and injectable forms, and its typical starting dose for adults ranges from 10 to 25 milligrams per day. The dosage may be gradually increased over time based on the individual's response to treatment. Common side effects of chlorprothixene include drowsiness, dizziness, dry mouth, constipation, and weight gain.

It is important to note that chlorprothixene can have serious side effects, including tardive dyskinesia (involuntary muscle movements), neuroleptic malignant syndrome (a rare but potentially fatal reaction to antipsychotic medication), and agranulocytosis (a severe decrease in white blood cell count). As with any medication, chlorprothixene should only be used under the close supervision of a healthcare provider.

Adrenergic uptake inhibitors are a class of medications that work by blocking the reuptake of neurotransmitters, such as norepinephrine and dopamine, into the presynaptic neuron. This results in an increase in the amount of neurotransmitter available to bind to postsynaptic receptors, leading to an enhancement of adrenergic transmission.

These medications are used in the treatment of various medical conditions, including depression, attention deficit hyperactivity disorder (ADHD), and narcolepsy. Some examples of adrenergic uptake inhibitors include:

* Tricyclic antidepressants (TCAs): These medications, such as imipramine and amitriptyline, were developed in the 1950s and are used to treat depression, anxiety disorders, and chronic pain.
* Selective serotonin-norepinephrine reuptake inhibitors (SNRIs): These medications, such as venlafaxine and duloxetine, were developed in the 1990s and are used to treat depression, anxiety disorders, and chronic pain.
* Norepinephrine-dopamine reuptake inhibitors (NDRIs): These medications, such as bupropion, are used to treat depression and ADHD.

It's important to note that these medications can have side effects and should be used under the supervision of a healthcare provider.

Fluvoxamine is a type of antidepressant known as a selective serotonin reuptake inhibitor (SSRI). It works by increasing the levels of serotonin, a neurotransmitter in the brain that helps maintain mental balance. Fluvoxamine is primarily used to treat obsessive-compulsive disorder (OCD) and may also be prescribed for other conditions such as depression, panic disorder, or social anxiety disorder.

The medical definition of Fluvoxamine can be stated as:

Fluvoxamine maleate, a selective serotonin reuptake inhibitor (SSRI), is a psychotropic medication used primarily in the treatment of obsessive-compulsive disorder (OCD). It functions by increasing the availability of serotonin in the synaptic cleft, which subsequently modulates neurotransmission and helps restore emotional balance. Fluvoxamine may also be employed off-label for managing other conditions, such as depression, panic disorder, or social anxiety disorder, subject to clinical judgment and patient needs.

I'm sorry for any confusion, but "swimming" is not typically considered a medical term. It refers to the act of moving through water using your arms and legs in a rhythmic pattern, often as a form of exercise, recreation, or competition. However, if you're referring to a medical condition related to swimming, such as "swimmer's ear" (otitis externa), I would be happy to provide a definition for that.

Swimmer's ear is a type of outer ear infection caused by water remaining in the ear after swimming or bathing, creating a moist environment that can lead to bacterial growth. It can also be caused by scratching or damaging the lining of the ear canal through the use of cotton swabs or other objects. Symptoms may include itching, redness, pain, and sometimes discharge from the ear. If left untreated, swimmer's ear can lead to more serious complications, such as hearing loss or damage to the inner ear.

Nomifensine is a medication that was previously used in the treatment of depression, but it is no longer available in many countries due to safety concerns. It is a non-tricyclic antidepressant that works by inhibiting the reuptake of dopamine and noradrenaline, which helps to increase the levels of these neurotransmitters in the brain and improve mood.

The medical definition of Nomifensine is:

"Nomifensine is a non-tricyclic antidepressant that is a potent inhibitor of dopamine and noradrenaline reuptake, with minimal effects on serotonin reuptake. It was used in the treatment of depression but has been withdrawn from the market due to safety concerns."

It's important to note that Nomifensine should only be taken under the supervision of a medical professional, and it is not available in many countries due to its potential for causing serious side effects such as liver toxicity and the risk of developing a rare but potentially fatal condition called hemolytic anemia.

Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) medication that is primarily used to treat major depressive disorder, obsessive-compulsive disorder, bulimia nervosa, panic disorder, and premenstrual dysphoric disorder. It works by increasing the levels of serotonin, a neurotransmitter in the brain that helps maintain mental balance.

Fluoxetine is available under the brand name Prozac and is also available as a generic medication. It comes in various forms, including capsules, tablets, delayed-release capsules, and liquid solution. The typical starting dose for adults with depression is 20 mg per day, but the dosage may be adjusted based on individual patient needs and response to treatment.

Fluoxetine has a relatively long half-life, which means it stays in the body for an extended period of time. This can be beneficial for patients who may have difficulty remembering to take their medication daily, as they may only need to take it once or twice a week. However, it also means that it may take several weeks for the full effects of the medication to become apparent.

As with any medication, fluoxetine can cause side effects, including nausea, dry mouth, sleepiness, insomnia, dizziness, and headache. In some cases, it may also increase the risk of suicidal thoughts or behavior in children, adolescents, and young adults, particularly during the initial stages of treatment. It is important for patients to discuss any concerns about side effects with their healthcare provider.

'Hypericum' is a genus of flowering plants, also known as St. John's Wort. While it is primarily used in herbal medicine and not considered a standard medical term, it is important to note that some species of Hypericum have been found to have medicinal properties. The most commonly studied and used species is Hypericum perforatum, which has been found to have potential benefits in treating depression, anxiety, and sleep disorders. However, its use as a medical treatment is still a subject of ongoing research and debate, and it can interact with several medications. Always consult with a healthcare provider before starting any new supplement or medication.

Trazodone is an antidepressant medication that belongs to the class of drugs called serotonin antagonist and reuptake inhibitors (SARIs). It works by increasing the levels of the neurotransmitter serotonin in the brain, which helps to improve mood and reduce symptoms of depression.

Trazodone is primarily used to treat major depressive disorder, but it may also be prescribed for anxiety, insomnia, and other conditions. The medication comes in various forms, including tablets and an extended-release formulation, and is typically taken orally one to three times a day. Common side effects of trazodone include dizziness, dry mouth, and sedation.

It's important to note that trazodone can interact with other medications and substances, so it's essential to inform your healthcare provider about all the drugs you are taking before starting treatment. Additionally, trazodone may increase the risk of suicidal thoughts or behavior in some people, particularly during the initial stages of treatment, so close monitoring is necessary.

Metyrapone is a medication that is primarily used in the diagnosis and treatment of Cushing's syndrome, a condition characterized by excessive levels of cortisol hormone in the body. It works as an inhibitor of steroidogenesis, specifically blocking the enzyme 11-beta-hydroxylase, which is involved in the production of cortisol in the adrenal gland.

By inhibiting this enzyme, metyrapone prevents the formation of cortisol and leads to an accumulation of its precursor, 11-deoxycortisol. This can help restore the balance of hormones in the body and alleviate symptoms associated with Cushing's syndrome.

It is important to note that metyrapone should only be used under the supervision of a healthcare professional, as it can have significant side effects and interactions with other medications.

Promazine is a type of medication known as a phenothiazine antipsychotic. It works by blocking the action of dopamine, a neurotransmitter in the brain that is involved in emotion and thought. Promazine is primarily used to treat schizophrenia and other psychotic disorders, as well as to manage agitation and anxiety in certain medical conditions. It may also be used for its sedative effects in the management of insomnia or related sleep disturbances.

Promazine was first synthesized in the 1940s and has been used in clinical practice since then. It is available in various forms, including tablets and injectable solutions, and is typically administered two to four times a day. Common side effects of promazine include dry mouth, blurred vision, constipation, dizziness, and orthostatic hypotension (a sudden drop in blood pressure upon standing). Less commonly, it can cause extrapyramidal symptoms, such as tremors, rigidity, and akathisia (restlessness and inability to sit still).

It is important to note that promazine and other phenothiazine antipsychotics have been largely replaced by newer, atypical antipsychotic medications due to their greater efficacy and lower risk of extrapyramidal side effects. However, promazine may still be used in certain cases where its specific properties are desired or when other treatments have failed. As with any medication, it should only be used under the close supervision of a healthcare provider, who can monitor for potential adverse effects and adjust the dosage as needed.

Nortriptyline is a tricyclic antidepressant (TCA) that is primarily used in the treatment of depression. It works by increasing the levels of certain neurotransmitters, such as serotonin and norepinephrine, in the brain. These neurotransmitters are involved in regulating mood, and increasing their levels can help to alleviate symptoms of depression.

Nortriptyline is available in oral form and is typically taken two or three times a day. It may take several weeks of treatment before the full benefits of the medication are felt. Common side effects of nortriptyline include dry mouth, blurred vision, constipation, and dizziness. In rare cases, it can cause more serious side effects such as heart rhythm problems, seizures, or increased suicidal thoughts or behavior.

Nortriptyline is generally considered to be safe and effective for the treatment of depression, but it should only be used under the close supervision of a healthcare provider due to its potential for serious side effects. It may also interact with other medications, so it is important to inform your doctor of all medications you are taking before starting nortriptyline.

Serotonin, also known as 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter that is found primarily in the gastrointestinal (GI) tract, blood platelets, and the central nervous system (CNS) of humans and other animals. It is produced by the conversion of the amino acid tryptophan to 5-hydroxytryptophan (5-HTP), and then to serotonin.

In the CNS, serotonin plays a role in regulating mood, appetite, sleep, memory, learning, and behavior, among other functions. It also acts as a vasoconstrictor, helping to regulate blood flow and blood pressure. In the GI tract, it is involved in peristalsis, the contraction and relaxation of muscles that moves food through the digestive system.

Serotonin is synthesized and stored in serotonergic neurons, which are nerve cells that use serotonin as their primary neurotransmitter. These neurons are found throughout the brain and spinal cord, and they communicate with other neurons by releasing serotonin into the synapse, the small gap between two neurons.

Abnormal levels of serotonin have been linked to a variety of disorders, including depression, anxiety, schizophrenia, and migraines. Medications that affect serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs), are commonly used to treat these conditions.

Doxepin is a tricyclic antidepressant (TCA) medication that is primarily used to treat depression and anxiety disorders. It works by increasing the levels of certain neurotransmitters, such as serotonin and norepinephrine, in the brain. Doxepin is also used in the treatment of insomnia, as it can help to improve sleep quality and reduce nighttime awakenings.

In addition to its antidepressant and sedative effects, doxepin has anti-inflammatory properties and is sometimes used off-label to treat chronic itching associated with various skin conditions, such as eczema and psoriasis.

Like other TCAs, doxepin can cause a range of side effects, including dry mouth, blurred vision, constipation, dizziness, and drowsiness. It may also cause weight gain, sexual dysfunction, and orthostatic hypotension (a drop in blood pressure upon standing). In rare cases, doxepin can cause more serious side effects, such as seizures, irregular heart rhythms, and serotonin syndrome (a potentially life-threatening condition caused by excessive levels of serotonin in the body).

Doxepin is available in immediate-release and extended-release forms, and is typically taken orally once or twice a day. The dosage may vary depending on the individual's age, weight, and medical history, as well as the specific condition being treated. It is important to follow the prescribing physician's instructions carefully when taking doxepin, and to report any unusual symptoms or side effects promptly.

Trimipramine is a type of antidepressant known as a tricyclic, which is used primarily to treat major depressive disorder. It works by increasing the levels of certain neurotransmitters (chemical messengers) in the brain, such as serotonin and norepinephrine, which help to regulate mood.

Trimipramine also has sedative properties and is sometimes used off-label for the treatment of insomnia or anxiety. It is available in immediate-release and extended-release forms, and is typically taken orally.

As with all medications, trimipramine can have side effects, which may include dry mouth, blurred vision, constipation, dizziness, drowsiness, and weight gain. In rare cases, it may cause more serious side effects such as heart rhythm abnormalities, seizures, or increased suicidal thoughts or behaviors in some individuals, particularly in children and adolescents.

It is important to take trimipramine exactly as prescribed by a healthcare provider, and to discuss any potential risks or benefits with them before starting treatment.

Sparteine is not typically referred to as a "medical definition" in the context of modern medicine. However, it is a chemical compound with some historical use in medicine and a well-defined chemical structure.

Here's a chemical definition of sparteine:

Sparteine is an alkaloid derived from plants of the genus *Colutea* and *Genista*, but most notably from *Crotalaria sagittalis* (rattlebox) and *Echium plantagineum* (viper's bugloss). Its chemical formula is C15H24N2, and it has a molecular weight of 228.36 g/mol.

Sparteine is a stereoisomer of lupanine and is structurally related to other natural alkaloids such as nicotine and coniine. It is a chiral compound with two stereocenters, existing as four different stereoisomers: (−)-sparteine, (+)-sparteine, (−)-pseudosparteine, and (+)-pseudosparteine.

Historically, sparteine has been used in medicine as a cardiotonic, uterine stimulant, and antispasmodic. However, due to its narrow therapeutic index and the availability of safer alternatives, it is no longer in common clinical use today.

Astemizole is a second-generation antihistamine that was previously used to treat symptoms associated with allergies, such as hay fever, hives, and other allergic skin reactions. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. However, astemizole has been withdrawn from the market in many countries due to rare but serious side effects on the heart.

Mephenytoin is defined as an anticonvulsant drug, specifically a hydantoin derivative, that is used in the treatment of complex partial seizures and generalized tonic-clonic seizures. It works by decreasing abnormal electrical activity in the brain. Mephenytoin has been largely replaced by other anticonvulsants due to its adverse effects such as rash, agranulocytosis, and liver toxicity. It is also known as Mesantoin or Mefenitoin.

Please note that this definition is for informational purposes only and should not be used as a medical advice. Always consult with a healthcare professional for accurate information regarding medications and their effects.

Paroxetine is a selective serotonin reuptake inhibitor (SSRI) medication that is primarily used to treat major depressive disorders, obsessive-compulsive disorder, panic disorder, social anxiety disorder, generalized anxiety disorder, and post-traumatic stress disorder. It works by increasing the levels of serotonin, a neurotransmitter in the brain that helps maintain mental balance, leading to an improvement in mood and other symptoms associated with these conditions.

Paroxetine is available under various brand names, such as Paxil and Seroxat, and it comes in different forms, including tablets, capsules, and liquid solutions. The medication is typically taken once daily, although the dosage may vary depending on the individual's needs and the specific condition being treated.

As with any medication, paroxetine can have side effects, such as nausea, dizziness, dry mouth, and sleep disturbances. In some cases, it may also cause more serious side effects, including increased risk of suicidal thoughts or behaviors in children, adolescents, and young adults, as well as an increased risk of bleeding and hyponatremia (low sodium levels).

It is important to consult with a healthcare provider before starting paroxetine or any other medication, and to follow their instructions carefully regarding dosage, timing, and potential interactions with other drugs or medical conditions.

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