The properties of a pathogen that makes it capable of infecting one or more specific hosts. The pathogen can include PARASITES as well as VIRUSES; BACTERIA; FUNGI; or PLANTS.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
The relationship between an invertebrate and another organism (the host), one of which lives at the expense of the other. Traditionally excluded from definition of parasites are pathogenic BACTERIA; FUNGI; VIRUSES; and PLANTS; though they may live parasitically.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A genus (and common name) in the AGAVACEAE family. It is known for SAPONINS in the root that are used in SOAPS.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The relationships of groups of organisms as reflected by their genetic makeup.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
The relationship between two different species of organisms that are interdependent; each gains benefits from the other or a relationship between different species where both of the organisms in question benefit from the presence of the other.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
The parts of a GENOME sequence that are involved with the different functions or properties of genomes as a whole as opposed to those of individual GENES.
Invertebrate organisms that live on or in another organism (the host), and benefit at the expense of the other. Traditionally excluded from definition of parasites are pathogenic BACTERIA; FUNGI; VIRUSES; and PLANTS; though they may live parasitically.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Diseases of plants.
A genus of gram-negative, aerobic, rod-shaped bacteria that activate PLANT ROOT NODULATION in leguminous plants. Members of this genus are nitrogen-fixing and common soil inhabitants.
A plant genus of the family MORACEAE. It is the source of the familiar fig fruit and the latex from this tree contains FICAIN.
The interactions between a host and a pathogen, usually resulting in disease.
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
Proteins found in the tail sections of DNA and RNA viruses. It is believed that these proteins play a role in directing chain folding and assembly of polypeptide chains.
The type species of the genus VESIVIRUS infecting pigs. The resulting infection is an acute febrile disease which is clinically indistinguishable from FOOT AND MOUTH DISEASE. Transmission is by contaminated food.
A genus in the family XANTHOMONADACEAE whose cells produce a yellow pigment (Gr. xanthos - yellow). It is pathogenic to plants.
Viruses whose host is Salmonella. A frequently encountered Salmonella phage is BACTERIOPHAGE P22.
Diseases of freshwater, marine, hatchery or aquarium fish. This term includes diseases of both teleosts (true fish) and elasmobranchs (sharks, rays and skates).
Deoxyribonucleic acid that makes up the genetic material of bacteria.
The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of "beans" belong to this family.
Proteins found in any species of bacterium.
Viruses whose nucleic acid is DNA.
Any of numerous winged hymenopterous insects of social as well as solitary habits and having formidable stings.
The functional hereditary units of BACTERIA.
A family of gram-negative bacteria which are saprophytes, symbionts, or plant pathogens.
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Genotypic differences observed among individuals in a population.
Viruses whose hosts are bacterial cells.
Multicellular, eukaryotic life forms of kingdom Plantae (sensu lato), comprising the VIRIDIPLANTAE; RHODOPHYTA; and GLAUCOPHYTA; all of which acquired chloroplasts by direct endosymbiosis of CYANOBACTERIA. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (MERISTEMS); cellulose within cells providing rigidity; the absence of organs of locomotion; absence of nervous and sensory systems; and an alternation of haploid and diploid generations.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
A large order of insects comprising the butterflies and moths.
The complete genetic complement contained in a DNA or RNA molecule in a virus.
A family of RNA viruses infecting insects and fish. There are two genera: Alphanodavirus and Betanodavirus.
The intergenic DNA segments that are between the ribosomal RNA genes (internal transcribed spacers) and between the tandemly repeated units of rDNA (external transcribed spacers and nontranscribed spacers).
The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.
Vertical transmission of hereditary characters by DNA from cytoplasmic organelles such as MITOCHONDRIA; CHLOROPLASTS; and PLASTIDS, or from PLASMIDS or viral episomal DNA.
Viruses whose genetic material is RNA.
The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.
A family of freshwater fish comprising the minnows or CARPS.
A phylum of fungi that produce their sexual spores (basidiospores) on the outside of the basidium. It includes forms commonly known as mushrooms, boletes, puffballs, earthstars, stinkhorns, bird's-nest fungi, jelly fungi, bracket or shelf fungi, and rust and smut fungi.
Warm-blooded VERTEBRATES possessing FEATHERS and belonging to the class Aves.
Diseases of birds not considered poultry, therefore usually found in zoos, parks, and the wild. The concept is differentiated from POULTRY DISEASES which is for birds raised as a source of meat or eggs for human consumption, and usually found in barnyards, hatcheries, etc.
The most diversified of all fish orders and the largest vertebrate order. It includes many of the commonly known fish such as porgies, croakers, sunfishes, dolphin fish, mackerels, TUNA, etc.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The genetic complement of a BACTERIA as represented in its DNA.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
A climate which is typical of equatorial and tropical regions, i.e., one with continually high temperatures with considerable precipitation, at least during part of the year. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Viruses whose host is Escherichia coli.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Woody, usually tall, perennial higher plants (Angiosperms, Gymnosperms, and some Pterophyta) having usually a main stem and numerous branches.
Proteins found in any species of virus.
Deoxyribonucleic acid that makes up the genetic material of viruses.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.
The process in certain BACTERIA; FUNGI; and CYANOBACTERIA converting free atmospheric NITROGEN to biologically usable forms of nitrogen, such as AMMONIA; NITRATES; and amino compounds.
A genus of coccidian parasites of the family CRYPTOSPORIDIIDAE, found in the intestinal epithelium of many vertebrates including humans.
Deoxyribonucleic acid that makes up the genetic material of protozoa.
Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
A field of study concerned with the principles and processes governing the geographic distributions of genealogical lineages, especially those within and among closely related species. (Avise, J.C., Phylogeography: The History and Formation of Species. Harvard University Press, 2000)
Wormlike or grublike stage, following the egg in the life cycle of insects, worms, and other metamorphosing animals.
DNA sequences encoding RIBOSOMAL RNA and the segments of DNA separating the individual ribosomal RNA genes, referred to as RIBOSOMAL SPACER DNA.
A functional system which includes the organisms of a natural community together with their environment. (McGraw Hill Dictionary of Scientific and Technical Terms, 4th ed)
Physicochemical property of fimbriated (FIMBRIAE, BACTERIAL) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. It is a factor in bacterial colonization and pathogenicity.
A group of cold-blooded, aquatic vertebrates having gills, fins, a cartilaginous or bony endoskeleton, and elongated bodies covered with scales.
A serotype of Salmonella enterica that is a frequent agent of Salmonella gastroenteritis in humans. It also causes PARATYPHOID FEVER.
Double-stranded DNA of MITOCHONDRIA. In eukaryotes, the mitochondrial GENOME is circular and codes for ribosomal RNAs, transfer RNAs, and about 10 proteins.
The naturally occurring transmission of genetic information between organisms, related or unrelated, circumventing parent-to-offspring transmission. Horizontal gene transfer may occur via a variety of naturally occurring processes such as GENETIC CONJUGATION; GENETIC TRANSDUCTION; and TRANSFECTION. It may result in a change of the recipient organism's genetic composition (TRANSFORMATION, GENETIC).
Constituent of 30S subunit prokaryotic ribosomes containing 1600 nucleotides and 21 proteins. 16S rRNA is involved in initiation of polypeptide synthesis.
A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.
The systematic study of the complete DNA sequences (GENOME) of organisms.
The variety of all native living organisms and their various forms and interrelationships.
Variation occurring within a species in the presence or length of DNA fragment generated by a specific endonuclease at a specific site in the genome. Such variations are generated by mutations that create or abolish recognition sites for these enzymes or change the length of the fragment.
Ribonucleic acid that makes up the genetic material of viruses.
Diseases of domestic cattle of the genus Bos. It includes diseases of cows, yaks, and zebus.
Deoxyribonucleic acid that makes up the genetic material of fungi.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
A multisubunit enzyme complex containing CYTOCHROME A GROUP; CYTOCHROME A3; two copper atoms; and 13 different protein subunits. It is the terminal oxidase complex of the RESPIRATORY CHAIN and collects electrons that are transferred from the reduced CYTOCHROME C GROUP and donates them to molecular OXYGEN, which is then reduced to water. The redox reaction is simultaneously coupled to the transport of PROTONS across the inner mitochondrial membrane.
Genes, found in both prokaryotes and eukaryotes, which are transcribed to produce the RNA which is incorporated into RIBOSOMES. Prokaryotic rRNA genes are usually found in OPERONS dispersed throughout the GENOME, whereas eukaryotic rRNA genes are clustered, multicistronic transcriptional units.
The rate dynamics in chemical or physical systems.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Procedures for identifying types and strains of bacteria. The most frequently employed typing systems are BACTERIOPHAGE TYPING and SEROTYPING as well as bacteriocin typing and biotyping.
Established cell cultures that have the potential to propagate indefinitely.
The functional hereditary units of VIRUSES.
Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Proteins prepared by recombinant DNA technology.
A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Sites on an antigen that interact with specific antibodies.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Antibodies produced by a single clone of cells.
Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.

Characterization of two host-specific genes, mannose-sensitive hemagglutinin (mshA) and uridyl phosphate dehydrogenase (UDPDH) that are involved in the Vibrio fischeri-Euprymna tasmanica mutualism. (1/413)

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Mutualism favours higher host specificity than does antagonism in plant-herbivore interaction. (2/413)

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Ecological factors driving the long-term evolution of influenza's host range. (3/413)

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Evaluation of infectivity and transmission of different Asian foot-and-mouth disease viruses in swine. (4/413)

Most isolates of foot-and-mouth disease virus (FMDV) display a broad host range. Since the late 1990s, the genetic lineage of PanAsia topotype FMDV serotype O has caused epidemics in the Far East, Africa, the United Kingdom, France, the Netherlands, and numerous other countries throughout Europe and Asia. In contrast, there are several FMDV isolates that exhibit a more restricted host range. A Cathay topotype isolate of FMDV serotype O from the 1997 epizootic in Taiwan (O/TAW/97) demonstrated restricted host specificity, only infecting swine. Methods used to evaluate infectivity and pathogenicity of FMDV isolates in cattle are well-documented, but there has been less progress studying transmission and pathogenicity of FMDV isolates in pigs. In previous studies designed to examine pathogenicity, various chimeric viruses derived from O/TAW/97 were intradermally inoculated in the heel bulb of pigs. Subsequent quantitative scoring of disease and evaluation of virus released into nasal secretions and blood was assessed. Here we prove the usefulness of this method in direct and contact inoculated pigs to evaluate infectivity, pathogenicity and transmission of different Asian FMDV isolates. Virus strains within the Cathay topotype were highly virulent in swine producing a synchronous disease in inoculated animals and were efficiently spread to in-contact naive pigs, while virus strains from the PanAsia topotype displayed more heterogeneous properties.  (+info)

Soil-strain compatibility: the key to effective use of arbuscular mycorrhizal inoculants? (5/413)

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Unique arbuscular mycorrhizal fungal communities uncovered in date palm plantations and surrounding desert habitats of Southern Arabia. (6/413)

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Alternate mechanisms of initial pattern recognition drive differential immune responses to related poxviruses. (7/413)

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Gall-induction in insects: evolutionary dead-end or speciation driver? (8/413)

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Host specificity, in the context of medical and infectious diseases, refers to the tendency of a pathogen (such as a virus, bacterium, or parasite) to infect and cause disease only in specific host species or individuals with certain genetic characteristics. This means that the pathogen is not able to establish infection or cause illness in other types of hosts. Host specificity can be determined by various factors such as the ability of the pathogen to attach to and enter host cells, replicate within the host, evade the host's immune response, and obtain necessary nutrients from the host. Understanding host specificity is important for developing effective strategies to prevent and control infectious diseases.

Species specificity is a term used in the field of biology, including medicine, to refer to the characteristic of a biological entity (such as a virus, bacterium, or other microorganism) that allows it to interact exclusively or preferentially with a particular species. This means that the biological entity has a strong affinity for, or is only able to infect, a specific host species.

For example, HIV is specifically adapted to infect human cells and does not typically infect other animal species. Similarly, some bacterial toxins are species-specific and can only affect certain types of animals or humans. This concept is important in understanding the transmission dynamics and host range of various pathogens, as well as in developing targeted therapies and vaccines.

Host-parasite interactions refer to the relationship between a parasitic organism (the parasite) and its host, which can be an animal, plant, or human body. The parasite lives on or inside the host and derives nutrients from it, often causing harm in the process. This interaction can range from relatively benign to severe, depending on various factors such as the species of the parasite, the immune response of the host, and the duration of infection.

The host-parasite relationship is often categorized based on the degree of harm caused to the host. Parasites that cause little to no harm are called commensals, while those that cause significant damage or disease are called parasitic pathogens. Some parasites can even manipulate their hosts' behavior and physiology to enhance their own survival and reproduction, leading to complex interactions between the two organisms.

Understanding host-parasite interactions is crucial for developing effective strategies to prevent and treat parasitic infections, as well as for understanding the ecological relationships between different species in natural ecosystems.

Sensitivity and specificity are statistical measures used to describe the performance of a diagnostic test or screening tool in identifying true positive and true negative results.

* Sensitivity refers to the proportion of people who have a particular condition (true positives) who are correctly identified by the test. It is also known as the "true positive rate" or "recall." A highly sensitive test will identify most or all of the people with the condition, but may also produce more false positives.
* Specificity refers to the proportion of people who do not have a particular condition (true negatives) who are correctly identified by the test. It is also known as the "true negative rate." A highly specific test will identify most or all of the people without the condition, but may also produce more false negatives.

In medical testing, both sensitivity and specificity are important considerations when evaluating a diagnostic test. High sensitivity is desirable for screening tests that aim to identify as many cases of a condition as possible, while high specificity is desirable for confirmatory tests that aim to rule out the condition in people who do not have it.

It's worth noting that sensitivity and specificity are often influenced by factors such as the prevalence of the condition in the population being tested, the threshold used to define a positive result, and the reliability and validity of the test itself. Therefore, it's important to consider these factors when interpreting the results of a diagnostic test.

I'm sorry for any confusion, but "Yucca" is not a medical term. It is a botanical term that refers to a genus of plants native to the hot and dry parts of North America, Central America, and the Caribbean. Some yucca species are known as "manihot" or "cassava," which are used in medicine and food production. However, the term "Yucca" itself does not have a medical definition.

Molecular sequence data refers to the specific arrangement of molecules, most commonly nucleotides in DNA or RNA, or amino acids in proteins, that make up a biological macromolecule. This data is generated through laboratory techniques such as sequencing, and provides information about the exact order of the constituent molecules. This data is crucial in various fields of biology, including genetics, evolution, and molecular biology, allowing for comparisons between different organisms, identification of genetic variations, and studies of gene function and regulation.

Phylogeny is the evolutionary history and relationship among biological entities, such as species or genes, based on their shared characteristics. In other words, it refers to the branching pattern of evolution that shows how various organisms have descended from a common ancestor over time. Phylogenetic analysis involves constructing a tree-like diagram called a phylogenetic tree, which depicts the inferred evolutionary relationships among organisms or genes based on molecular sequence data or other types of characters. This information is crucial for understanding the diversity and distribution of life on Earth, as well as for studying the emergence and spread of diseases.

Substrate specificity in the context of medical biochemistry and enzymology refers to the ability of an enzyme to selectively bind and catalyze a chemical reaction with a particular substrate (or a group of similar substrates) while discriminating against other molecules that are not substrates. This specificity arises from the three-dimensional structure of the enzyme, which has evolved to match the shape, charge distribution, and functional groups of its physiological substrate(s).

Substrate specificity is a fundamental property of enzymes that enables them to carry out highly selective chemical transformations in the complex cellular environment. The active site of an enzyme, where the catalysis takes place, has a unique conformation that complements the shape and charge distribution of its substrate(s). This ensures efficient recognition, binding, and conversion of the substrate into the desired product while minimizing unwanted side reactions with other molecules.

Substrate specificity can be categorized as:

1. Absolute specificity: An enzyme that can only act on a single substrate or a very narrow group of structurally related substrates, showing no activity towards any other molecule.
2. Group specificity: An enzyme that prefers to act on a particular functional group or class of compounds but can still accommodate minor structural variations within the substrate.
3. Broad or promiscuous specificity: An enzyme that can act on a wide range of structurally diverse substrates, albeit with varying catalytic efficiencies.

Understanding substrate specificity is crucial for elucidating enzymatic mechanisms, designing drugs that target specific enzymes or pathways, and developing biotechnological applications that rely on the controlled manipulation of enzyme activities.

In the context of medicine and biology, symbiosis is a type of close and long-term biological interaction between two different biological organisms. Generally, one organism, called the symbiont, lives inside or on another organism, called the host. This interaction can be mutually beneficial (mutualistic), harmful to the host organism (parasitic), or have no effect on either organism (commensal).

Examples of mutualistic symbiotic relationships in humans include the bacteria that live in our gut and help us digest food, as well as the algae that live inside corals and provide them with nutrients. Parasitic symbioses, on the other hand, involve organisms like viruses or parasitic worms that live inside a host and cause harm to it.

It's worth noting that while the term "symbiosis" is often used in popular culture to refer to any close relationship between two organisms, in scientific contexts it has a more specific meaning related to long-term biological interactions.

DNA Sequence Analysis is the systematic determination of the order of nucleotides in a DNA molecule. It is a critical component of modern molecular biology, genetics, and genetic engineering. The process involves determining the exact order of the four nucleotide bases - adenine (A), guanine (G), cytosine (C), and thymine (T) - in a DNA molecule or fragment. This information is used in various applications such as identifying gene mutations, studying evolutionary relationships, developing molecular markers for breeding, and diagnosing genetic diseases.

The process of DNA Sequence Analysis typically involves several steps, including DNA extraction, PCR amplification (if necessary), purification, sequencing reaction, and electrophoresis. The resulting data is then analyzed using specialized software to determine the exact sequence of nucleotides.

In recent years, high-throughput DNA sequencing technologies have revolutionized the field of genomics, enabling the rapid and cost-effective sequencing of entire genomes. This has led to an explosion of genomic data and new insights into the genetic basis of many diseases and traits.

A genome is the complete set of genetic material, including all the genes and non-coding DNA, that an organism possesses. Genome components refer to the individual parts that make up this genetic material. These can include:

1. **Genes**: These are segments of DNA that contain the instructions for making proteins or RNA molecules. They are the fundamental units of heredity and can be passed down from one generation to the next.

2. **Chromosomes**: These are thread-like structures located in the nucleus of a cell that consist of DNA tightly coiled around histones. Humans have 23 pairs of chromosomes for a total of 46.

3. **Non-coding DNA**: This is DNA that does not contain instructions for making proteins. It was once thought to be "junk" DNA, but it's now known to have various functions, such as regulating gene expression and providing structural support to chromosomes.

4. **Mitochondrial DNA (mtDNA)**: This is the genetic material found in mitochondria, the energy-producing structures in a cell. In humans, mtDNA is inherited solely from the mother.

5. **Epigenetic modifications**: These are changes to the genome that do not involve alterations to the DNA sequence itself but can influence gene expression. They include DNA methylation and histone modification.

6. **Mobile genetic elements (transposons or jumping genes)**: These are sequences of DNA that can move around and change position within the genome, potentially disrupting or enhancing the function of nearby genes.

Each of these components plays a unique role in the functioning of the organism's genome and can influence its characteristics, development, and health.

A parasite is an organism that lives on or in a host organism and gets its sustenance at the expense of the host. Parasites are typically much smaller than their hosts, and they may be classified as either ectoparasites (which live on the outside of the host's body) or endoparasites (which live inside the host's body).

Parasites can cause a range of health problems in humans, depending on the type of parasite and the extent of the infection. Some parasites may cause only mild symptoms or none at all, while others can lead to serious illness or even death. Common symptoms of parasitic infections include diarrhea, abdominal pain, weight loss, and fatigue.

There are many different types of parasites that can infect humans, including protozoa (single-celled organisms), helminths (worms), and ectoparasites (such as lice and ticks). Parasitic infections are more common in developing countries with poor sanitation and hygiene, but they can also occur in industrialized nations.

Preventing parasitic infections typically involves practicing good hygiene, such as washing hands regularly, cooking food thoroughly, and avoiding contaminated water. Treatment for parasitic infections usually involves medication to kill the parasites and relieve symptoms.

A base sequence in the context of molecular biology refers to the specific order of nucleotides in a DNA or RNA molecule. In DNA, these nucleotides are adenine (A), guanine (G), cytosine (C), and thymine (T). In RNA, uracil (U) takes the place of thymine. The base sequence contains genetic information that is transcribed into RNA and ultimately translated into proteins. It is the exact order of these bases that determines the genetic code and thus the function of the DNA or RNA molecule.

An amino acid sequence is the specific order of amino acids in a protein or peptide molecule, formed by the linking of the amino group (-NH2) of one amino acid to the carboxyl group (-COOH) of another amino acid through a peptide bond. The sequence is determined by the genetic code and is unique to each type of protein or peptide. It plays a crucial role in determining the three-dimensional structure and function of proteins.

A plant disease is a disorder that affects the normal growth and development of plants, caused by pathogenic organisms such as bacteria, viruses, fungi, parasites, or nematodes, as well as environmental factors like nutrient deficiencies, extreme temperatures, or physical damage. These diseases can cause various symptoms, including discoloration, wilting, stunted growth, necrosis, and reduced yield or productivity, which can have significant economic and ecological impacts.

Rhizobium is not a medical term, but rather a term used in microbiology and agriculture. It refers to a genus of gram-negative bacteria that can fix nitrogen from the atmosphere into ammonia, which can then be used by plants as a nutrient. These bacteria live in the root nodules of leguminous plants (such as beans, peas, and clover) and form a symbiotic relationship with them.

The host plant provides Rhizobium with carbon sources and a protected environment within the root nodule, while the bacteria provide the plant with fixed nitrogen. This mutualistic interaction plays a crucial role in maintaining soil fertility and promoting plant growth.

While Rhizobium itself is not directly related to human health or medicine, understanding its symbiotic relationship with plants can have implications for agricultural practices, sustainable farming, and global food security.

"Ficus" is not a medical term. It is a genus of plants, including the fig tree, which is widely distributed in tropical and subtropical regions. Some species of Ficus are used in traditional medicine, but "Ficus" itself does not have a specific medical definition.

Host-pathogen interactions refer to the complex and dynamic relationship between a living organism (the host) and a disease-causing agent (the pathogen). This interaction can involve various molecular, cellular, and physiological processes that occur between the two entities. The outcome of this interaction can determine whether the host will develop an infection or not, as well as the severity and duration of the illness.

During host-pathogen interactions, the pathogen may release virulence factors that allow it to evade the host's immune system, colonize tissues, and obtain nutrients for its survival and replication. The host, in turn, may mount an immune response to recognize and eliminate the pathogen, which can involve various mechanisms such as inflammation, phagocytosis, and the production of antimicrobial agents.

Understanding the intricacies of host-pathogen interactions is crucial for developing effective strategies to prevent and treat infectious diseases. This knowledge can help identify new targets for therapeutic interventions, inform vaccine design, and guide public health policies to control the spread of infectious agents.

Virulence, in the context of medicine and microbiology, refers to the degree or severity of damage or harm that a pathogen (like a bacterium, virus, fungus, or parasite) can cause to its host. It is often associated with the ability of the pathogen to invade and damage host tissues, evade or suppress the host's immune response, replicate within the host, and spread between hosts.

Virulence factors are the specific components or mechanisms that contribute to a pathogen's virulence, such as toxins, enzymes, adhesins, and capsules. These factors enable the pathogen to establish an infection, cause tissue damage, and facilitate its transmission between hosts. The overall virulence of a pathogen can be influenced by various factors, including host susceptibility, environmental conditions, and the specific strain or species of the pathogen.

I'm sorry for any confusion, but "viral tail proteins" is not a widely recognized or established medical term. The term "tail proteins" is used in the context of certain viruses, particularly bacteriophages (viruses that infect bacteria), which have a tail-like structure that helps them attach to and inject their genetic material into host cells.

However, even within this context, there isn't a specific concept known as "viral tail proteins" that has a widely accepted medical definition. The proteins that make up the tail structure of bacteriophages have various functions and are referred to by different names based on their roles. These can include terms like "tail fiber proteins," "tail tube proteins," "tail terminator proteins," etc.

If you're looking for information about a specific protein or group of proteins related to viral tails, I would be happy to help further if you could provide more details.

Vesicular exanthema of swine (VES) is a viral disease that affects pigs, characterized by the formation of blisters or vesicles on the skin and mucous membranes. The causative agent of VES is a member of the Caliciviridae family, specifically the vesicular exanthema of swine virus (VESV).

The disease is highly contagious and can spread rapidly in pig populations through direct contact with infected animals or contaminated fomites. The incubation period for VES is typically 2-6 days, after which affected pigs may develop fever, lethargy, loss of appetite, and lameness. Within a few days, small fluid-filled vesicles appear on the snout, lips, ears, and coronary bands of the hooves. These vesicles can rupture, leading to the formation of raw, painful erosions that may become secondarily infected with bacteria.

While VES is not a direct threat to human health, it can cause significant economic losses in the swine industry due to decreased growth rates, reduced feed conversion, and increased mortality in affected animals. Additionally, the clinical signs of VES are similar to those of other vesicular diseases, such as foot-and-mouth disease (FMD), which can lead to costly trade restrictions and quarantines.

Historically, VES was a significant problem in the United States swine industry, but extensive vaccination programs and eradication efforts have largely eliminated the disease from domestic pig populations. However, VESV continues to circulate in wild pig populations and remains a potential threat to the swine industry.

Xanthomonas is a genus of Gram-negative, rod-shaped bacteria that are widely distributed in various environments, including water, soil, and plant surfaces. They are known to cause diseases in plants, such as black rot in crucifers, bacterial spot in tomatoes and peppers, and citrus canker in citrus trees. Some species of Xanthomonas can also infect humans, although this is relatively rare. Infections in humans typically occur through contact with contaminated water or soil, and can cause various symptoms such as pneumonia, skin infections, and bloodstream infections. However, it's important to note that Xanthomonas species are not typically associated with human diseases and are mainly known for their impact on plants.

Salmonella phages are viruses that infect and replicate within bacteria of the genus Salmonella. These phages, also known as bacteriophages or simply phages, are composed of a protein capsid that encases the genetic material, which can be either DNA or RNA. They specifically target Salmonella bacteria, using the bacteria's resources to replicate and produce new phage particles. This process often leads to the lysis (breaking open) of the bacterial cell, resulting in the release of newly formed phages.

Salmonella phages have been studied as potential alternatives to antibiotics for controlling Salmonella infections, particularly in food production settings. They offer the advantage of being highly specific to their target bacteria, reducing the risk of disrupting beneficial microbiota. However, further research is needed to fully understand their safety and efficacy before they can be widely used as therapeutic or prophylactic agents.

"Fish diseases" is a broad term that refers to various health conditions and infections affecting fish populations in aquaculture, ornamental fish tanks, or wild aquatic environments. These diseases can be caused by bacteria, viruses, fungi, parasites, or environmental factors such as water quality, temperature, and stress.

Some common examples of fish diseases include:

1. Bacterial diseases: Examples include furunculosis (caused by Aeromonas salmonicida), columnaris disease (caused by Flavobacterium columnare), and enteric septicemia of catfish (caused by Edwardsiella ictaluri).

2. Viral diseases: Examples include infectious pancreatic necrosis virus (IPNV) in salmonids, viral hemorrhagic septicemia virus (VHSV), and koi herpesvirus (KHV).

3. Fungal diseases: Examples include saprolegniasis (caused by Saprolegnia spp.) and cotton wool disease (caused by Aphanomyces spp.).

4. Parasitic diseases: Examples include ichthyophthirius multifiliis (Ich), costia, trichodina, and various worm infestations such as anchor worms (Lernaea spp.) and tapeworms (Diphyllobothrium spp.).

5. Environmental diseases: These are caused by poor water quality, temperature stress, or other environmental factors that weaken the fish's immune system and make them more susceptible to infections. Examples include osmoregulatory disorders, ammonia toxicity, and low dissolved oxygen levels.

It is essential to diagnose and treat fish diseases promptly to prevent their spread among fish populations and maintain healthy aquatic ecosystems. Preventative measures such as proper sanitation, water quality management, biosecurity practices, and vaccination can help reduce the risk of fish diseases in both farmed and ornamental fish settings.

Bacterial DNA refers to the genetic material found in bacteria. It is composed of a double-stranded helix containing four nucleotide bases - adenine (A), thymine (T), guanine (G), and cytosine (C) - that are linked together by phosphodiester bonds. The sequence of these bases in the DNA molecule carries the genetic information necessary for the growth, development, and reproduction of bacteria.

Bacterial DNA is circular in most bacterial species, although some have linear chromosomes. In addition to the main chromosome, many bacteria also contain small circular pieces of DNA called plasmids that can carry additional genes and provide resistance to antibiotics or other environmental stressors.

Unlike eukaryotic cells, which have their DNA enclosed within a nucleus, bacterial DNA is present in the cytoplasm of the cell, where it is in direct contact with the cell's metabolic machinery. This allows for rapid gene expression and regulation in response to changing environmental conditions.

Fabaceae is the scientific name for a family of flowering plants commonly known as the legume, pea, or bean family. This family includes a wide variety of plants that are important economically, agriculturally, and ecologically. Many members of Fabaceae have compound leaves and produce fruits that are legumes, which are long, thin pods that contain seeds. Some well-known examples of plants in this family include beans, peas, lentils, peanuts, clover, and alfalfa.

In addition to their importance as food crops, many Fabaceae species have the ability to fix nitrogen from the atmosphere into the soil through a symbiotic relationship with bacteria that live in nodules on their roots. This makes them valuable for improving soil fertility and is one reason why they are often used in crop rotation and as cover crops.

It's worth noting that Fabaceae is sometimes still referred to by its older scientific name, Leguminosae.

Bacterial proteins are a type of protein that are produced by bacteria as part of their structural or functional components. These proteins can be involved in various cellular processes, such as metabolism, DNA replication, transcription, and translation. They can also play a role in bacterial pathogenesis, helping the bacteria to evade the host's immune system, acquire nutrients, and multiply within the host.

Bacterial proteins can be classified into different categories based on their function, such as:

1. Enzymes: Proteins that catalyze chemical reactions in the bacterial cell.
2. Structural proteins: Proteins that provide structural support and maintain the shape of the bacterial cell.
3. Signaling proteins: Proteins that help bacteria to communicate with each other and coordinate their behavior.
4. Transport proteins: Proteins that facilitate the movement of molecules across the bacterial cell membrane.
5. Toxins: Proteins that are produced by pathogenic bacteria to damage host cells and promote infection.
6. Surface proteins: Proteins that are located on the surface of the bacterial cell and interact with the environment or host cells.

Understanding the structure and function of bacterial proteins is important for developing new antibiotics, vaccines, and other therapeutic strategies to combat bacterial infections.

DNA viruses are a type of virus that contain DNA (deoxyribonucleic acid) as their genetic material. These viruses replicate by using the host cell's machinery to synthesize new viral components, which are then assembled into new viruses and released from the host cell.

DNA viruses can be further classified based on the structure of their genomes and the way they replicate. For example, double-stranded DNA (dsDNA) viruses have a genome made up of two strands of DNA, while single-stranded DNA (ssDNA) viruses have a genome made up of a single strand of DNA.

Examples of DNA viruses include herpes simplex virus, varicella-zoster virus, human papillomavirus, and adenoviruses. Some DNA viruses are associated with specific diseases, such as cancer (e.g., human papillomavirus) or neurological disorders (e.g., herpes simplex virus).

It's important to note that while DNA viruses contain DNA as their genetic material, RNA viruses contain RNA (ribonucleic acid) as their genetic material. Both DNA and RNA viruses can cause a wide range of diseases in humans, animals, and plants.

I'm sorry for any confusion, but "wasps" is not a term that has a specific medical definition. Wasps are a type of insect in the order Hymenoptera, and some people can have allergic reactions to their stings. However, there is no medical condition or disease specifically associated with wasps. If you have any specific medical concerns or questions, I would be happy to try to help if I can!

A bacterial gene is a segment of DNA (or RNA in some viruses) that contains the genetic information necessary for the synthesis of a functional bacterial protein or RNA molecule. These genes are responsible for encoding various characteristics and functions of bacteria such as metabolism, reproduction, and resistance to antibiotics. They can be transmitted between bacteria through horizontal gene transfer mechanisms like conjugation, transformation, and transduction. Bacterial genes are often organized into operons, which are clusters of genes that are transcribed together as a single mRNA molecule.

It's important to note that the term "bacterial gene" is used to describe genetic elements found in bacteria, but not all genetic elements in bacteria are considered genes. For example, some DNA sequences may not encode functional products and are therefore not considered genes. Additionally, some bacterial genes may be plasmid-borne or phage-borne, rather than being located on the bacterial chromosome.

Rhizobiaceae is a family of bacteria that have the ability to fix nitrogen. These bacteria are gram-negative, motile, and rod-shaped. They are commonly found in the root nodules of leguminous plants, where they form a symbiotic relationship with the plant. The bacteria provide the plant with fixed nitrogen, while the plant provides the bacteria with carbon and a protected environment.

The most well-known genus of Rhizobiaceae is Rhizobium, which includes several species that are important for agriculture because of their ability to fix nitrogen in the root nodules of legumes. Other genera in this family include Bradyrhizobium, Mesorhizobium, and Sinorhizobium.

It's worth noting that while Rhizobiaceae bacteria are generally beneficial, they can sometimes cause disease in plants under certain conditions. For example, some strains of Rhizobium can cause leaf spots on certain crops.

Antibody specificity refers to the ability of an antibody to bind to a specific epitope or antigenic determinant on an antigen. Each antibody has a unique structure that allows it to recognize and bind to a specific region of an antigen, typically a small portion of the antigen's surface made up of amino acids or sugar residues. This highly specific binding is mediated by the variable regions of the antibody's heavy and light chains, which form a pocket that recognizes and binds to the epitope.

The specificity of an antibody is determined by its unique complementarity-determining regions (CDRs), which are loops of amino acids located in the variable domains of both the heavy and light chains. The CDRs form a binding site that recognizes and interacts with the epitope on the antigen. The precise fit between the antibody's binding site and the epitope is critical for specificity, as even small changes in the structure of either can prevent binding.

Antibody specificity is important in immune responses because it allows the immune system to distinguish between self and non-self antigens. This helps to prevent autoimmune reactions where the immune system attacks the body's own cells and tissues. Antibody specificity also plays a crucial role in diagnostic tests, such as ELISA assays, where antibodies are used to detect the presence of specific antigens in biological samples.

Genetic variation refers to the differences in DNA sequences among individuals and populations. These variations can result from mutations, genetic recombination, or gene flow between populations. Genetic variation is essential for evolution by providing the raw material upon which natural selection acts. It can occur within a single gene, between different genes, or at larger scales, such as differences in the number of chromosomes or entire sets of chromosomes. The study of genetic variation is crucial in understanding the genetic basis of diseases and traits, as well as the evolutionary history and relationships among species.

Bacteriophages, often simply called phages, are viruses that infect and replicate within bacteria. They consist of a protein coat, called the capsid, that encases the genetic material, which can be either DNA or RNA. Bacteriophages are highly specific, meaning they only infect certain types of bacteria, and they reproduce by hijacking the bacterial cell's machinery to produce more viruses.

Once a phage infects a bacterium, it can either replicate its genetic material and create new phages (lytic cycle), or integrate its genetic material into the bacterial chromosome and replicate along with the bacterium (lysogenic cycle). In the lytic cycle, the newly formed phages are released by lysing, or breaking open, the bacterial cell.

Bacteriophages play a crucial role in shaping microbial communities and have been studied as potential alternatives to antibiotics for treating bacterial infections.

I apologize for any confusion, but "plants" is not a term that has a medical definition. The term "plants" refers to a large and diverse group of organisms that obtain their energy through photosynthesis, which is the process of converting sunlight into chemical energy. Plants are typically characterized by having cells with cell walls containing cellulose, chloroplasts containing the pigment chlorophyll, and the ability to synthesize their own food through photosynthesis.

In a medical or biological context, you might be thinking of "plant-based" or "phytomedicine," which refer to the use of plants or plant extracts as a form of medicine or treatment. Phytomedicines have been used for thousands of years in many traditional systems of medicine, and some plant-derived compounds have been found to have therapeutic benefits in modern medicine as well. However, "plants" itself does not have a medical definition.

Polymerase Chain Reaction (PCR) is a laboratory technique used to amplify specific regions of DNA. It enables the production of thousands to millions of copies of a particular DNA sequence in a rapid and efficient manner, making it an essential tool in various fields such as molecular biology, medical diagnostics, forensic science, and research.

The PCR process involves repeated cycles of heating and cooling to separate the DNA strands, allow primers (short sequences of single-stranded DNA) to attach to the target regions, and extend these primers using an enzyme called Taq polymerase, resulting in the exponential amplification of the desired DNA segment.

In a medical context, PCR is often used for detecting and quantifying specific pathogens (viruses, bacteria, fungi, or parasites) in clinical samples, identifying genetic mutations or polymorphisms associated with diseases, monitoring disease progression, and evaluating treatment effectiveness.

'Escherichia coli' (E. coli) is a type of gram-negative, facultatively anaerobic, rod-shaped bacterium that commonly inhabits the intestinal tract of humans and warm-blooded animals. It is a member of the family Enterobacteriaceae and one of the most well-studied prokaryotic model organisms in molecular biology.

While most E. coli strains are harmless and even beneficial to their hosts, some serotypes can cause various forms of gastrointestinal and extraintestinal illnesses in humans and animals. These pathogenic strains possess virulence factors that enable them to colonize and damage host tissues, leading to diseases such as diarrhea, urinary tract infections, pneumonia, and sepsis.

E. coli is a versatile organism with remarkable genetic diversity, which allows it to adapt to various environmental niches. It can be found in water, soil, food, and various man-made environments, making it an essential indicator of fecal contamination and a common cause of foodborne illnesses. The study of E. coli has contributed significantly to our understanding of fundamental biological processes, including DNA replication, gene regulation, and protein synthesis.

I'm sorry for any confusion, but "Lepidoptera" is not a medical term. It is a taxonomic order that includes moths and butterflies, which are insects known for their distinctive wing scales. This term is used in the field of biology, not medicine.

A viral genome is the genetic material (DNA or RNA) that is present in a virus. It contains all the genetic information that a virus needs to replicate itself and infect its host. The size and complexity of viral genomes can vary greatly, ranging from a few thousand bases to hundreds of thousands of bases. Some viruses have linear genomes, while others have circular genomes. The genome of a virus also contains the information necessary for the virus to hijack the host cell's machinery and use it to produce new copies of the virus. Understanding the genetic makeup of viruses is important for developing vaccines and antiviral treatments.

Nodaviridae is a family of small, non-enveloped viruses with icosahedral symmetry. The genome consists of two positive-sense, single-stranded RNA segments: RNA1 (3.1 kb) encodes the RNA-dependent RNA polymerase and RNA2 (1.4 kb) encodes the capsid protein. A subgenomic RNA3 is also produced from RNA1 during replication, which encodes a non-structural protein involved in viral replication. Nodaviruses infect insects and fish and can cause diseases such as encephalopathy and retinopathy in fish. They are transmitted horizontally through the fecal-oral route and vertically through the egg. Nodaviridae is a member of the order Picornavirales.

The ribosomal spacer in DNA refers to the non-coding sequences of DNA that are located between the genes for ribosomal RNA (rRNA). These spacer regions are present in the DNA of organisms that have a nuclear genome, including humans and other animals, plants, and fungi.

In prokaryotic cells, such as bacteria, there are two ribosomal RNA genes, 16S and 23S, separated by a spacer region known as the intergenic spacer (IGS). In eukaryotic cells, there are multiple copies of ribosomal RNA genes arranged in clusters called nucleolar organizer regions (NORs), which are located on the short arms of several acrocentric chromosomes. Each cluster contains hundreds to thousands of copies of the 18S, 5.8S, and 28S rRNA genes, separated by non-transcribed spacer regions known as internal transcribed spacers (ITS) and external transcribed spacers (ETS).

The ribosomal spacer regions in DNA are often used as molecular markers for studying evolutionary relationships among organisms because they evolve more rapidly than the rRNA genes themselves. The sequences of these spacer regions can be compared among different species to infer their phylogenetic relationships and to estimate the time since they diverged from a common ancestor. Additionally, the length and composition of ribosomal spacers can vary between individuals within a species, making them useful for studying genetic diversity and population structure.

Molecular evolution is the process of change in the DNA sequence or protein structure over time, driven by mechanisms such as mutation, genetic drift, gene flow, and natural selection. It refers to the evolutionary study of changes in DNA, RNA, and proteins, and how these changes accumulate and lead to new species and diversity of life. Molecular evolution can be used to understand the history and relationships among different organisms, as well as the functional consequences of genetic changes.

Extrachromosomal inheritance refers to the transmission of genetic information that occurs outside of the chromosomes, which are the structures in the cell nucleus that typically contain and transmit genetic material. This type of inheritance is relatively rare and can involve various types of genetic elements, such as plasmids or transposons.

In extrachromosomal inheritance, these genetic elements can replicate independently of the chromosomes and be passed on to offspring through mechanisms other than traditional Mendelian inheritance. This can lead to non-Mendelian patterns of inheritance, where traits do not follow the expected dominant or recessive patterns.

One example of extrachromosomal inheritance is the transmission of mitochondrial DNA (mtDNA), which occurs in the cytoplasm of the cell rather than on the chromosomes. Mitochondria are organelles that produce energy for the cell, and they contain their own small circular genome that is inherited maternally. Mutations in mtDNA can lead to a variety of genetic disorders, including mitochondrial diseases.

Overall, extrachromosomal inheritance is an important area of study in genetics, as it can help researchers better understand the complex ways in which genetic information is transmitted and expressed in living organisms.

RNA viruses are a type of virus that contain ribonucleic acid (RNA) as their genetic material, as opposed to deoxyribonucleic acid (DNA). RNA viruses replicate by using an enzyme called RNA-dependent RNA polymerase to transcribe and replicate their RNA genome.

There are several different groups of RNA viruses, including:

1. Negative-sense single-stranded RNA viruses: These viruses have a genome that is complementary to the mRNA and must undergo transcription to produce mRNA before translation can occur. Examples include influenza virus, measles virus, and rabies virus.
2. Positive-sense single-stranded RNA viruses: These viruses have a genome that can serve as mRNA and can be directly translated into protein after entry into the host cell. Examples include poliovirus, rhinoviruses, and coronaviruses.
3. Double-stranded RNA viruses: These viruses have a genome consisting of double-stranded RNA and use a complex replication strategy involving both transcription and reverse transcription. Examples include rotaviruses and reoviruses.

RNA viruses are known to cause a wide range of human diseases, ranging from the common cold to more severe illnesses such as hepatitis C, polio, and COVID-19. Due to their high mutation rates and ability to adapt quickly to new environments, RNA viruses can be difficult to control and treat with antiviral drugs or vaccines.

Biological evolution is the change in the genetic composition of populations of organisms over time, from one generation to the next. It is a process that results in descendants differing genetically from their ancestors. Biological evolution can be driven by several mechanisms, including natural selection, genetic drift, gene flow, and mutation. These processes can lead to changes in the frequency of alleles (variants of a gene) within populations, resulting in the development of new species and the extinction of others over long periods of time. Biological evolution provides a unifying explanation for the diversity of life on Earth and is supported by extensive evidence from many different fields of science, including genetics, paleontology, comparative anatomy, and biogeography.

Cyprinidae is a family of fish that includes carps, minnows, and barbs. It is the largest family of freshwater fish, with over 2,400 species found worldwide, particularly in Asia and Europe. These fish are characterized by their lack of teeth on the roof of their mouths and have a single dorsal fin. Some members of this family are economically important as food fish or for aquarium trade.

Basidiomycota is a phylum in the kingdom Fungi that consists of organisms commonly known as club fungi or club mushrooms. The name Basidiomycota is derived from the presence of a characteristic reproductive structure called a basidium, which is where spores are produced.

The basidiomycetes include many familiar forms such as mushrooms, toadstools, bracket fungi, and other types of polypores. They have a complex life cycle that involves both sexual and asexual reproduction. The sexual reproductive stage produces a characteristic fruiting body, which may be microscopic or highly visible, depending on the species.

Basidiomycota fungi play important ecological roles in decomposing organic matter, forming mutualistic relationships with plants, and acting as parasites on other organisms. Some species are economically important, such as edible mushrooms, while others can be harmful or even deadly to humans and animals.

I am not aware of a medical definition for the term "birds." Birds are a group of warm-blooded vertebrates constituting the class Aves, characterized by feathers, toothless beaked jaws, the laying of hard-shelled eggs, and lightweight but strong skeletons. Some birds, such as pigeons and chickens, have been used in medical research, but the term "birds" itself does not have a specific medical definition.

'Bird diseases' is a broad term that refers to the various medical conditions and infections that can affect avian species. These diseases can be caused by bacteria, viruses, fungi, parasites, or toxic substances and can affect pet birds, wild birds, and poultry. Some common bird diseases include:

1. Avian influenza (bird flu) - a viral infection that can cause respiratory symptoms, decreased appetite, and sudden death in birds.
2. Psittacosis (parrot fever) - a bacterial infection that can cause respiratory symptoms, fever, and lethargy in birds and humans who come into contact with them.
3. Aspergillosis - a fungal infection that can cause respiratory symptoms and weight loss in birds.
4. Candidiasis (thrush) - a fungal infection that can affect the mouth, crop, and other parts of the digestive system in birds.
5. Newcastle disease - a viral infection that can cause respiratory symptoms, neurological signs, and decreased egg production in birds.
6. Salmonellosis - a bacterial infection that can cause diarrhea, lethargy, and decreased appetite in birds and humans who come into contact with them.
7. Trichomoniasis - a parasitic infection that can affect the mouth, crop, and digestive system in birds.
8. Chlamydiosis (psittacosis) - a bacterial infection that can cause respiratory symptoms, lethargy, and decreased appetite in birds and humans who come into contact with them.
9. Coccidiosis - a parasitic infection that can affect the digestive system in birds.
10. Mycobacteriosis (avian tuberculosis) - a bacterial infection that can cause chronic weight loss, respiratory symptoms, and skin lesions in birds.

It is important to note that some bird diseases can be transmitted to humans and other animals, so it is essential to practice good hygiene when handling birds or their droppings. If you suspect your bird may be sick, it is best to consult with a veterinarian who specializes in avian medicine.

I'm sorry for any confusion, but "Perciformes" is not a medical term. It is a term used in the field of biology, specifically in taxonomy and ichthyology (the study of fish). Perciformes is an order of ray-finned bony fishes that includes over 10,000 species, making it the largest order of vertebrates. Examples of fish within this order include perch, sea bass, sunfish, and tuna.

A mutation is a permanent change in the DNA sequence of an organism's genome. Mutations can occur spontaneously or be caused by environmental factors such as exposure to radiation, chemicals, or viruses. They may have various effects on the organism, ranging from benign to harmful, depending on where they occur and whether they alter the function of essential proteins. In some cases, mutations can increase an individual's susceptibility to certain diseases or disorders, while in others, they may confer a survival advantage. Mutations are the driving force behind evolution, as they introduce new genetic variability into populations, which can then be acted upon by natural selection.

A bacterial genome is the complete set of genetic material, including both DNA and RNA, found within a single bacterium. It contains all the hereditary information necessary for the bacterium to grow, reproduce, and survive in its environment. The bacterial genome typically includes circular chromosomes, as well as plasmids, which are smaller, circular DNA molecules that can carry additional genes. These genes encode various functional elements such as enzymes, structural proteins, and regulatory sequences that determine the bacterium's characteristics and behavior.

Bacterial genomes vary widely in size, ranging from around 130 kilobases (kb) in Mycoplasma genitalium to over 14 megabases (Mb) in Sorangium cellulosum. The complete sequencing and analysis of bacterial genomes have provided valuable insights into the biology, evolution, and pathogenicity of bacteria, enabling researchers to better understand their roles in various diseases and potential applications in biotechnology.

In genetics, sequence alignment is the process of arranging two or more DNA, RNA, or protein sequences to identify regions of similarity or homology between them. This is often done using computational methods to compare the nucleotide or amino acid sequences and identify matching patterns, which can provide insight into evolutionary relationships, functional domains, or potential genetic disorders. The alignment process typically involves adjusting gaps and mismatches in the sequences to maximize the similarity between them, resulting in an aligned sequence that can be visually represented and analyzed.

I'm sorry for any confusion, but "tropical climate" is not a medical term. It is a geographical term that refers to the climate of tropical regions, which are located around the equator. These regions are characterized by high temperatures and consistent rainfall throughout the year.

However, it's worth noting that certain environmental factors, such as climate, can have an impact on human health. For instance, tropical climates can contribute to the spread of certain diseases, like malaria and dengue fever, due to the presence of mosquitoes that thrive in warm, wet environments. But a "tropical climate" itself is not a medical condition or diagnosis.

Coliphages are viruses that infect and replicate within certain species of bacteria that belong to the coliform group, particularly Escherichia coli (E. coli). These viruses are commonly found in water and soil environments and are frequently used as indicators of fecal contamination in water quality testing. Coliphages are not harmful to humans or animals, but their presence in water can suggest the potential presence of pathogenic bacteria or other microorganisms that may pose a health risk. There are two main types of coliphages: F-specific RNA coliphages and somatic (or non-F specific) DNA coliphages.

"Cattle" is a term used in the agricultural and veterinary fields to refer to domesticated animals of the genus *Bos*, primarily *Bos taurus* (European cattle) and *Bos indicus* (Zebu). These animals are often raised for meat, milk, leather, and labor. They are also known as bovines or cows (for females), bulls (intact males), and steers/bullocks (castrated males). However, in a strict medical definition, "cattle" does not apply to humans or other animals.

A plasmid is a small, circular, double-stranded DNA molecule that is separate from the chromosomal DNA of a bacterium or other organism. Plasmids are typically not essential for the survival of the organism, but they can confer beneficial traits such as antibiotic resistance or the ability to degrade certain types of pollutants.

Plasmids are capable of replicating independently of the chromosomal DNA and can be transferred between bacteria through a process called conjugation. They often contain genes that provide resistance to antibiotics, heavy metals, and other environmental stressors. Plasmids have also been engineered for use in molecular biology as cloning vectors, allowing scientists to replicate and manipulate specific DNA sequences.

Plasmids are important tools in genetic engineering and biotechnology because they can be easily manipulated and transferred between organisms. They have been used to produce vaccines, diagnostic tests, and genetically modified organisms (GMOs) for various applications, including agriculture, medicine, and industry.

Molecular cloning is a laboratory technique used to create multiple copies of a specific DNA sequence. This process involves several steps:

1. Isolation: The first step in molecular cloning is to isolate the DNA sequence of interest from the rest of the genomic DNA. This can be done using various methods such as PCR (polymerase chain reaction), restriction enzymes, or hybridization.
2. Vector construction: Once the DNA sequence of interest has been isolated, it must be inserted into a vector, which is a small circular DNA molecule that can replicate independently in a host cell. Common vectors used in molecular cloning include plasmids and phages.
3. Transformation: The constructed vector is then introduced into a host cell, usually a bacterial or yeast cell, through a process called transformation. This can be done using various methods such as electroporation or chemical transformation.
4. Selection: After transformation, the host cells are grown in selective media that allow only those cells containing the vector to grow. This ensures that the DNA sequence of interest has been successfully cloned into the vector.
5. Amplification: Once the host cells have been selected, they can be grown in large quantities to amplify the number of copies of the cloned DNA sequence.

Molecular cloning is a powerful tool in molecular biology and has numerous applications, including the production of recombinant proteins, gene therapy, functional analysis of genes, and genetic engineering.

I'm sorry for any confusion, but "trees" is not a medical term. It is a common term used in various fields, including biology, ecology, and dendrology, to refer to a woody perennial plant with a single stem or trunk that supports branches and leaves in most species.

If you have any questions related to medical terminology or health-related topics, please provide more context so I can offer an accurate and helpful response.

Viral proteins are the proteins that are encoded by the viral genome and are essential for the viral life cycle. These proteins can be structural or non-structural and play various roles in the virus's replication, infection, and assembly process. Structural proteins make up the physical structure of the virus, including the capsid (the protein shell that surrounds the viral genome) and any envelope proteins (that may be present on enveloped viruses). Non-structural proteins are involved in the replication of the viral genome and modulation of the host cell environment to favor viral replication. Overall, a thorough understanding of viral proteins is crucial for developing antiviral therapies and vaccines.

Viral DNA refers to the genetic material present in viruses that consist of DNA as their core component. Deoxyribonucleic acid (DNA) is one of the two types of nucleic acids that are responsible for storing and transmitting genetic information in living organisms. Viruses are infectious agents much smaller than bacteria that can only replicate inside the cells of other organisms, called hosts.

Viral DNA can be double-stranded (dsDNA) or single-stranded (ssDNA), depending on the type of virus. Double-stranded DNA viruses have a genome made up of two complementary strands of DNA, while single-stranded DNA viruses contain only one strand of DNA.

Examples of dsDNA viruses include Adenoviruses, Herpesviruses, and Poxviruses, while ssDNA viruses include Parvoviruses and Circoviruses. Viral DNA plays a crucial role in the replication cycle of the virus, encoding for various proteins necessary for its multiplication and survival within the host cell.

Sequence homology, amino acid, refers to the similarity in the order of amino acids in a protein or a portion of a protein between two or more species. This similarity can be used to infer evolutionary relationships and functional similarities between proteins. The higher the degree of sequence homology, the more likely it is that the proteins are related and have similar functions. Sequence homology can be determined through various methods such as pairwise alignment or multiple sequence alignment, which compare the sequences and calculate a score based on the number and type of matching amino acids.

Medicinal plants are defined as those plants that contain naturally occurring chemical compounds which can be used for therapeutic purposes, either directly or indirectly. These plants have been used for centuries in various traditional systems of medicine, such as Ayurveda, Chinese medicine, and Native American medicine, to prevent or treat various health conditions.

Medicinal plants contain a wide variety of bioactive compounds, including alkaloids, flavonoids, tannins, terpenes, and saponins, among others. These compounds have been found to possess various pharmacological properties, such as anti-inflammatory, analgesic, antimicrobial, antioxidant, and anticancer activities.

Medicinal plants can be used in various forms, including whole plant material, extracts, essential oils, and isolated compounds. They can be administered through different routes, such as oral, topical, or respiratory, depending on the desired therapeutic effect.

It is important to note that while medicinal plants have been used safely and effectively for centuries, they should be used with caution and under the guidance of a healthcare professional. Some medicinal plants can interact with prescription medications or have adverse effects if used inappropriately.

Nitrogen fixation is a process by which nitrogen gas (N2) in the air is converted into ammonia (NH3) or other chemically reactive forms, making it available to plants and other organisms for use as a nutrient. This process is essential for the nitrogen cycle and for the growth of many types of plants, as most plants cannot utilize nitrogen gas directly from the air.

In the medical field, nitrogen fixation is not a commonly used term. However, in the context of microbiology and infectious diseases, some bacteria are capable of fixing nitrogen and this ability can contribute to their pathogenicity. For example, certain species of bacteria that colonize the human body, such as those found in the gut or on the skin, may be able to fix nitrogen and use it for their own growth and survival. In some cases, these bacteria may also release fixed nitrogen into the environment, which can have implications for the ecology and health of the host and surrounding ecosystems.

Cryptosporidium is a genus of protozoan parasites that can cause the diarrheal disease known as cryptosporidiosis in humans and animals. These microscopic pathogens infect the epithelial cells of the gastrointestinal tract, primarily in the small intestine, leading to symptoms such as watery diarrhea, stomach cramps, nausea, vomiting, fever, and dehydration.

Cryptosporidium parasites have a complex life cycle, including several developmental stages within host cells. They are protected by an outer shell called oocyst, which allows them to survive outside the host's body for extended periods, making them resistant to chlorine-based disinfectants commonly used in water treatment.

Transmission of Cryptosporidium occurs through the fecal-oral route, often via contaminated water or food, or direct contact with infected individuals or animals. People at higher risk for severe illness include young children, elderly people, pregnant women, and those with weakened immune systems due to HIV/AIDS, cancer treatment, or organ transplantation.

Preventive measures include proper hand hygiene, avoiding consumption of untreated water or raw fruits and vegetables likely to be contaminated, and practicing safe sex. For immunocompromised individuals, antiparasitic medications such as nitazoxanide may help reduce the severity and duration of symptoms.

There doesn't seem to be a specific medical definition for "DNA, protozoan" as it is simply a reference to the DNA found in protozoa. Protozoa are single-celled eukaryotic organisms that can be found in various environments such as soil, water, and the digestive tracts of animals.

Protozoan DNA refers to the genetic material present in these organisms. It is composed of nucleic acids, including deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), which contain the instructions for the development, growth, and reproduction of the protozoan.

The DNA in protozoa, like in other organisms, is made up of two strands of nucleotides that coil together to form a double helix. The four nucleotide bases that make up protozoan DNA are adenine (A), thymine (T), guanine (G), and cytosine (C). These bases pair with each other to form the rungs of the DNA ladder, with A always pairing with T and G always pairing with C.

The genetic information stored in protozoan DNA is encoded in the sequence of these nucleotide bases. This information is used to synthesize proteins, which are essential for the structure and function of the organism's cells. Protozoan DNA also contains other types of genetic material, such as regulatory sequences that control gene expression and repetitive elements with no known function.

Understanding the DNA of protozoa is important for studying their biology, evolution, and pathogenicity. It can help researchers develop new treatments for protozoan diseases and gain insights into the fundamental principles of genetics and cellular function.

Feces are the solid or semisolid remains of food that could not be digested or absorbed in the small intestine, along with bacteria and other waste products. After being stored in the colon, feces are eliminated from the body through the rectum and anus during defecation. Feces can vary in color, consistency, and odor depending on a person's diet, health status, and other factors.

Phylogeography is not a medical term, but rather a subfield of biogeography and phylogenetics that investigates the spatial distribution of genealogical lineages and the historical processes that have shaped them. It uses genetic data to infer the geographic origins, dispersal routes, and demographic history of organisms, including pathogens and vectors that can affect human health.

In medical and public health contexts, phylogeography is often used to study the spread of infectious diseases, such as HIV/AIDS, influenza, or tuberculosis, by analyzing the genetic diversity and geographic distribution of pathogen isolates. This information can help researchers understand how diseases emerge, evolve, and move across populations and landscapes, which can inform disease surveillance, control, and prevention strategies.

A larva is a distinct stage in the life cycle of various insects, mites, and other arthropods during which they undergo significant metamorphosis before becoming adults. In a medical context, larvae are known for their role in certain parasitic infections. Specifically, some helminth (parasitic worm) species use larval forms to infect human hosts. These invasions may lead to conditions such as cutaneous larva migrans, visceral larva migrans, or gnathostomiasis, depending on the specific parasite involved and the location of the infection within the body.

The larval stage is characterized by its markedly different morphology and behavior compared to the adult form. Larvae often have a distinct appearance, featuring unsegmented bodies, simple sense organs, and undeveloped digestive systems. They are typically adapted for a specific mode of life, such as free-living or parasitic existence, and rely on external sources of nutrition for their development.

In the context of helminth infections, larvae may be transmitted to humans through various routes, including ingestion of contaminated food or water, direct skin contact with infective stages, or transmission via an intermediate host (such as a vector). Once inside the human body, these parasitic larvae can cause tissue damage and provoke immune responses, leading to the clinical manifestations of disease.

It is essential to distinguish between the medical definition of 'larva' and its broader usage in biology and zoology. In those fields, 'larva' refers to any juvenile form that undergoes metamorphosis before reaching adulthood, regardless of whether it is parasitic or not.

Ribosomal DNA (rDNA) refers to the specific regions of DNA in a cell that contain the genes for ribosomal RNA (rRNA). Ribosomes are complex structures composed of proteins and rRNA, which play a crucial role in protein synthesis by translating messenger RNA (mRNA) into proteins.

In humans, there are four types of rRNA molecules: 18S, 5.8S, 28S, and 5S. These rRNAs are encoded by multiple copies of rDNA genes that are organized in clusters on specific chromosomes. In humans, the majority of rDNA genes are located on the short arms of acrocentric chromosomes 13, 14, 15, 21, and 22.

Each cluster of rDNA genes contains both transcribed and non-transcribed spacer regions. The transcribed regions contain the genes for the four types of rRNA, while the non-transcribed spacers contain regulatory elements that control the transcription of the rRNA genes.

The number of rDNA copies varies between species and even within individuals of the same species. The copy number can also change during development and in response to environmental factors. Variations in rDNA copy number have been associated with various diseases, including cancer and neurological disorders.

An "ecosystem" is not a term that has a specific medical definition, as it is a concept that is more commonly used in the fields of ecology and environmental science. However, I can provide you with the general ecological definition of an ecosystem:

An ecosystem is a community of living organisms interacting with each other and their non-living environment, including both biotic factors (plants, animals, microorganisms) and abiotic factors (climate, soil, water, and air). These interactions create a complex network of relationships that form the foundation of ecological processes, such as energy flow, nutrient cycling, and population dynamics.

While there is no direct medical definition for an ecosystem, understanding the principles of ecosystems can have important implications for human health. For example, healthy ecosystems can provide clean air and water, regulate climate, support food production, and offer opportunities for recreation and relaxation, all of which contribute to overall well-being. Conversely, degraded ecosystems can lead to increased exposure to environmental hazards, reduced access to natural resources, and heightened risks of infectious diseases. Therefore, maintaining the health and integrity of ecosystems is crucial for promoting human health and preventing disease.

Bacterial adhesion is the initial and crucial step in the process of bacterial colonization, where bacteria attach themselves to a surface or tissue. This process involves specific interactions between bacterial adhesins (proteins, fimbriae, or pili) and host receptors (glycoproteins, glycolipids, or extracellular matrix components). The attachment can be either reversible or irreversible, depending on the strength of interaction. Bacterial adhesion is a significant factor in initiating biofilm formation, which can lead to various infectious diseases and medical device-associated infections.

I believe there may be a misunderstanding in your question. The term "fishes" is not typically used in a medical context. "Fish" or "fishes" refers to any aquatic organism belonging to the taxonomic class Actinopterygii (bony fish), Chondrichthyes (sharks and rays), or Agnatha (jawless fish).

However, if you are referring to a condition related to fish or consuming fish, there is a medical issue called scombroid fish poisoning. It's a foodborne illness caused by eating spoiled or improperly stored fish from the Scombridae family, which includes tuna, mackerel, and bonito, among others. The bacteria present in these fish can produce histamine, which can cause symptoms like skin flushing, headache, diarrhea, and itchy rash. But again, this is not related to the term "fishes" itself but rather a condition associated with consuming certain types of fish.

"Salmonella enterica" serovar "Typhimurium" is a subspecies of the bacterial species Salmonella enterica, which is a gram-negative, facultatively anaerobic, rod-shaped bacterium. It is a common cause of foodborne illness in humans and animals worldwide. The bacteria can be found in a variety of sources, including contaminated food and water, raw meat, poultry, eggs, and dairy products.

The infection caused by Salmonella Typhimurium is typically self-limiting and results in gastroenteritis, which is characterized by symptoms such as diarrhea, abdominal cramps, fever, and vomiting. However, in some cases, the infection can spread to other parts of the body and cause more severe illness, particularly in young children, older adults, and people with weakened immune systems.

Salmonella Typhimurium is a major public health concern due to its ability to cause outbreaks of foodborne illness, as well as its potential to develop antibiotic resistance. Proper food handling, preparation, and storage practices can help prevent the spread of Salmonella Typhimurium and other foodborne pathogens.

Mitochondrial DNA (mtDNA) is the genetic material present in the mitochondria, which are specialized structures within cells that generate energy. Unlike nuclear DNA, which is present in the cell nucleus and inherited from both parents, mtDNA is inherited solely from the mother.

MtDNA is a circular molecule that contains 37 genes, including 13 genes that encode for proteins involved in oxidative phosphorylation, a process that generates energy in the form of ATP. The remaining genes encode for rRNAs and tRNAs, which are necessary for protein synthesis within the mitochondria.

Mutations in mtDNA can lead to a variety of genetic disorders, including mitochondrial diseases, which can affect any organ system in the body. These mutations can also be used in forensic science to identify individuals and establish biological relationships.

Horizontal gene transfer (HGT), also known as lateral gene transfer, is the movement of genetic material between organisms in a manner other than from parent to offspring (vertical gene transfer). In horizontal gene transfer, an organism can take up genetic material directly from its environment and incorporate it into its own genome. This process is common in bacteria and archaea, but has also been observed in eukaryotes including plants and animals.

Horizontal gene transfer can occur through several mechanisms, including:

1. Transformation: the uptake of free DNA from the environment by a cell.
2. Transduction: the transfer of genetic material between cells by a virus (bacteriophage).
3. Conjugation: the direct transfer of genetic material between two cells in physical contact, often facilitated by a conjugative plasmid or other mobile genetic element.

Horizontal gene transfer can play an important role in the evolution and adaptation of organisms, allowing them to acquire new traits and functions rapidly. It is also of concern in the context of genetically modified organisms (GMOs) and antibiotic resistance, as it can facilitate the spread of genes that confer resistance or other undesirable traits.

Ribosomal RNA (rRNA) is a type of RNA that combines with proteins to form ribosomes, which are complex structures inside cells where protein synthesis occurs. The "16S" refers to the sedimentation coefficient of the rRNA molecule, which is a measure of its size and shape. In particular, 16S rRNA is a component of the smaller subunit of the prokaryotic ribosome (found in bacteria and archaea), and is often used as a molecular marker for identifying and classifying these organisms due to its relative stability and conservation among species. The sequence of 16S rRNA can be compared across different species to determine their evolutionary relationships and taxonomic positions.

An open reading frame (ORF) is a continuous stretch of DNA or RNA sequence that has the potential to be translated into a protein. It begins with a start codon (usually "ATG" in DNA, which corresponds to "AUG" in RNA) and ends with a stop codon ("TAA", "TAG", or "TGA" in DNA; "UAA", "UAG", or "UGA" in RNA). The sequence between these two points is called a coding sequence (CDS), which, when transcribed into mRNA and translated into amino acids, forms a polypeptide chain.

In eukaryotic cells, ORFs can be located in either protein-coding genes or non-coding regions of the genome. In prokaryotic cells, multiple ORFs may be present on a single strand of DNA, often organized into operons that are transcribed together as a single mRNA molecule.

It's important to note that not all ORFs necessarily represent functional proteins; some may be pseudogenes or result from errors in genome annotation. Therefore, additional experimental evidence is typically required to confirm the expression and functionality of a given ORF.

DNA primers are short single-stranded DNA molecules that serve as a starting point for DNA synthesis. They are typically used in laboratory techniques such as the polymerase chain reaction (PCR) and DNA sequencing. The primer binds to a complementary sequence on the DNA template through base pairing, providing a free 3'-hydroxyl group for the DNA polymerase enzyme to add nucleotides and synthesize a new strand of DNA. This allows for specific and targeted amplification or analysis of a particular region of interest within a larger DNA molecule.

Cluster analysis is a statistical method used to group similar objects or data points together based on their characteristics or features. In medical and healthcare research, cluster analysis can be used to identify patterns or relationships within complex datasets, such as patient records or genetic information. This technique can help researchers to classify patients into distinct subgroups based on their symptoms, diagnoses, or other variables, which can inform more personalized treatment plans or public health interventions.

Cluster analysis involves several steps, including:

1. Data preparation: The researcher must first collect and clean the data, ensuring that it is complete and free from errors. This may involve removing outlier values or missing data points.
2. Distance measurement: Next, the researcher must determine how to measure the distance between each pair of data points. Common methods include Euclidean distance (the straight-line distance between two points) or Manhattan distance (the distance between two points along a grid).
3. Clustering algorithm: The researcher then applies a clustering algorithm, which groups similar data points together based on their distances from one another. Common algorithms include hierarchical clustering (which creates a tree-like structure of clusters) or k-means clustering (which assigns each data point to the nearest centroid).
4. Validation: Finally, the researcher must validate the results of the cluster analysis by evaluating the stability and robustness of the clusters. This may involve re-running the analysis with different distance measures or clustering algorithms, or comparing the results to external criteria.

Cluster analysis is a powerful tool for identifying patterns and relationships within complex datasets, but it requires careful consideration of the data preparation, distance measurement, and validation steps to ensure accurate and meaningful results.

In the context of medical and biological sciences, a "binding site" refers to a specific location on a protein, molecule, or cell where another molecule can attach or bind. This binding interaction can lead to various functional changes in the original protein or molecule. The other molecule that binds to the binding site is often referred to as a ligand, which can be a small molecule, ion, or even another protein.

The binding between a ligand and its target binding site can be specific and selective, meaning that only certain ligands can bind to particular binding sites with high affinity. This specificity plays a crucial role in various biological processes, such as signal transduction, enzyme catalysis, or drug action.

In the case of drug development, understanding the location and properties of binding sites on target proteins is essential for designing drugs that can selectively bind to these sites and modulate protein function. This knowledge can help create more effective and safer therapeutic options for various diseases.

Genetic recombination is the process by which genetic material is exchanged between two similar or identical molecules of DNA during meiosis, resulting in new combinations of genes on each chromosome. This exchange occurs during crossover, where segments of DNA are swapped between non-sister homologous chromatids, creating genetic diversity among the offspring. It is a crucial mechanism for generating genetic variability and facilitating evolutionary change within populations. Additionally, recombination also plays an essential role in DNA repair processes through mechanisms such as homologous recombinational repair (HRR) and non-homologous end joining (NHEJ).

Genomics is the scientific study of genes and their functions. It involves the sequencing and analysis of an organism's genome, which is its complete set of DNA, including all of its genes. Genomics also includes the study of how genes interact with each other and with the environment. This field of study can provide important insights into the genetic basis of diseases and can lead to the development of new diagnostic tools and treatments.

Biodiversity is the variety of different species of plants, animals, and microorganisms that live in an ecosystem. It also includes the variety of genes within a species and the variety of ecosystems (such as forests, grasslands, deserts, and oceans) that exist in a region or on Earth as a whole. Biodiversity is important for maintaining the health and balance of ecosystems, providing resources and services such as food, clean water, and pollination, and contributing to the discovery of new medicines and other useful products. The loss of biodiversity can have negative impacts on the functioning of ecosystems and the services they provide, and can threaten the survival of species and the livelihoods of people who depend on them.

Restriction Fragment Length Polymorphism (RFLP) is a term used in molecular biology and genetics. It refers to the presence of variations in DNA sequences among individuals, which can be detected by restriction enzymes. These enzymes cut DNA at specific sites, creating fragments of different lengths.

In RFLP analysis, DNA is isolated from an individual and treated with a specific restriction enzyme that cuts the DNA at particular recognition sites. The resulting fragments are then separated by size using gel electrophoresis, creating a pattern unique to that individual's DNA. If there are variations in the DNA sequence between individuals, the restriction enzyme may cut the DNA at different sites, leading to differences in the length of the fragments and thus, a different pattern on the gel.

These variations can be used for various purposes, such as identifying individuals, diagnosing genetic diseases, or studying evolutionary relationships between species. However, RFLP analysis has largely been replaced by more modern techniques like polymerase chain reaction (PCR)-based methods and DNA sequencing, which offer higher resolution and throughput.

A viral RNA (ribonucleic acid) is the genetic material found in certain types of viruses, as opposed to viruses that contain DNA (deoxyribonucleic acid). These viruses are known as RNA viruses. The RNA can be single-stranded or double-stranded and can exist as several different forms, such as positive-sense, negative-sense, or ambisense RNA. Upon infecting a host cell, the viral RNA uses the host's cellular machinery to translate the genetic information into proteins, leading to the production of new virus particles and the continuation of the viral life cycle. Examples of human diseases caused by RNA viruses include influenza, COVID-19 (SARS-CoV-2), hepatitis C, and polio.

Cattle diseases are a range of health conditions that affect cattle, which include but are not limited to:

1. Bovine Respiratory Disease (BRD): Also known as "shipping fever," BRD is a common respiratory illness in feedlot cattle that can be caused by several viruses and bacteria.
2. Bovine Viral Diarrhea (BVD): A viral disease that can cause a variety of symptoms, including diarrhea, fever, and reproductive issues.
3. Johne's Disease: A chronic wasting disease caused by the bacterium Mycobacterium avium subspecies paratuberculosis. It primarily affects the intestines and can cause severe diarrhea and weight loss.
4. Digital Dermatitis: Also known as "hairy heel warts," this is a highly contagious skin disease that affects the feet of cattle, causing lameness and decreased productivity.
5. Infectious Bovine Keratoconjunctivitis (IBK): Also known as "pinkeye," IBK is a common and contagious eye infection in cattle that can cause blindness if left untreated.
6. Salmonella: A group of bacteria that can cause severe gastrointestinal illness in cattle, including diarrhea, dehydration, and septicemia.
7. Leptospirosis: A bacterial disease that can cause a wide range of symptoms in cattle, including abortion, stillbirths, and kidney damage.
8. Blackleg: A highly fatal bacterial disease that causes rapid death in young cattle. It is caused by Clostridium chauvoei and vaccination is recommended for prevention.
9. Anthrax: A serious infectious disease caused by the bacterium Bacillus anthracis. Cattle can become infected by ingesting spores found in contaminated soil, feed or water.
10. Foot-and-Mouth Disease (FMD): A highly contagious viral disease that affects cloven-hooved animals, including cattle. It is characterized by fever and blisters on the feet, mouth, and teats. FMD is not a threat to human health but can have serious economic consequences for the livestock industry.

It's important to note that many of these diseases can be prevented or controlled through good management practices, such as vaccination, biosecurity measures, and proper nutrition. Regular veterinary care and monitoring are also crucial for early detection and treatment of any potential health issues in your herd.

Fungal DNA refers to the genetic material present in fungi, which are a group of eukaryotic organisms that include microorganisms such as yeasts and molds, as well as larger organisms like mushrooms. The DNA of fungi, like that of all living organisms, is made up of nucleotides that are arranged in a double helix structure.

Fungal DNA contains the genetic information necessary for the growth, development, and reproduction of fungi. This includes the instructions for making proteins, which are essential for the structure and function of cells, as well as other important molecules such as enzymes and nucleic acids.

Studying fungal DNA can provide valuable insights into the biology and evolution of fungi, as well as their potential uses in medicine, agriculture, and industry. For example, researchers have used genetic engineering techniques to modify the DNA of fungi to produce drugs, biofuels, and other useful products. Additionally, understanding the genetic makeup of pathogenic fungi can help scientists develop new strategies for preventing and treating fungal infections.

Genotype, in genetics, refers to the complete heritable genetic makeup of an individual organism, including all of its genes. It is the set of instructions contained in an organism's DNA for the development and function of that organism. The genotype is the basis for an individual's inherited traits, and it can be contrasted with an individual's phenotype, which refers to the observable physical or biochemical characteristics of an organism that result from the expression of its genes in combination with environmental influences.

It is important to note that an individual's genotype is not necessarily identical to their genetic sequence. Some genes have multiple forms called alleles, and an individual may inherit different alleles for a given gene from each parent. The combination of alleles that an individual inherits for a particular gene is known as their genotype for that gene.

Understanding an individual's genotype can provide important information about their susceptibility to certain diseases, their response to drugs and other treatments, and their risk of passing on inherited genetic disorders to their offspring.

Electron Transport Complex IV is also known as Cytochrome c oxidase. It is the last complex in the electron transport chain, located in the inner mitochondrial membrane of eukaryotic cells and the plasma membrane of prokaryotic cells. This complex contains 13 subunits, two heme groups (a and a3), and three copper centers (A, B, and C).

In the electron transport chain, Complex IV receives electrons from cytochrome c and transfers them to molecular oxygen, reducing it to water. This process is accompanied by the pumping of protons across the membrane, contributing to the generation of a proton gradient that drives ATP synthesis via ATP synthase (Complex V). The overall reaction catalyzed by Complex IV can be summarized as follows:

4e- + 4H+ + O2 → 2H2O

Defects in Cytochrome c oxidase can lead to various diseases, including mitochondrial encephalomyopathies and neurodegenerative disorders.

rRNA (ribosomal RNA) is not a type of gene itself, but rather a crucial component that is transcribed from genes known as ribosomal DNA (rDNA). In cells, rRNA plays an essential role in protein synthesis by assembling with ribosomal proteins to form ribosomes. Ribosomes are complex structures where the translation of mRNA into proteins occurs. There are multiple types of rRNA molecules, including 5S, 5.8S, 18S, and 28S rRNAs in eukaryotic cells, each with specific functions during protein synthesis.

In summary, 'Genes, rRNA' would refer to the genetic regions (genes) that code for ribosomal RNA molecules, which are vital components of the protein synthesis machinery within cells.

In the context of medicine and pharmacology, "kinetics" refers to the study of how a drug moves throughout the body, including its absorption, distribution, metabolism, and excretion (often abbreviated as ADME). This field is called "pharmacokinetics."

1. Absorption: This is the process of a drug moving from its site of administration into the bloodstream. Factors such as the route of administration (e.g., oral, intravenous, etc.), formulation, and individual physiological differences can affect absorption.

2. Distribution: Once a drug is in the bloodstream, it gets distributed throughout the body to various tissues and organs. This process is influenced by factors like blood flow, protein binding, and lipid solubility of the drug.

3. Metabolism: Drugs are often chemically modified in the body, typically in the liver, through processes known as metabolism. These changes can lead to the formation of active or inactive metabolites, which may then be further distributed, excreted, or undergo additional metabolic transformations.

4. Excretion: This is the process by which drugs and their metabolites are eliminated from the body, primarily through the kidneys (urine) and the liver (bile).

Understanding the kinetics of a drug is crucial for determining its optimal dosing regimen, potential interactions with other medications or foods, and any necessary adjustments for special populations like pediatric or geriatric patients, or those with impaired renal or hepatic function.

I apologize, but "sheep" is not a term that has a medical definition. It is a common animal with the scientific name Ovis aries. If you have any medical or health-related questions, I would be happy to try and help answer those for you.

Protein binding, in the context of medical and biological sciences, refers to the interaction between a protein and another molecule (known as the ligand) that results in a stable complex. This process is often reversible and can be influenced by various factors such as pH, temperature, and concentration of the involved molecules.

In clinical chemistry, protein binding is particularly important when it comes to drugs, as many of them bind to proteins (especially albumin) in the bloodstream. The degree of protein binding can affect a drug's distribution, metabolism, and excretion, which in turn influence its therapeutic effectiveness and potential side effects.

Protein-bound drugs may be less available for interaction with their target tissues, as only the unbound or "free" fraction of the drug is active. Therefore, understanding protein binding can help optimize dosing regimens and minimize adverse reactions.

Sequence homology in nucleic acids refers to the similarity or identity between the nucleotide sequences of two or more DNA or RNA molecules. It is often used as a measure of biological relationship between genes, organisms, or populations. High sequence homology suggests a recent common ancestry or functional constraint, while low sequence homology may indicate a more distant relationship or different functions.

Nucleic acid sequence homology can be determined by various methods such as pairwise alignment, multiple sequence alignment, and statistical analysis. The degree of homology is typically expressed as a percentage of identical or similar nucleotides in a given window of comparison.

It's important to note that the interpretation of sequence homology depends on the biological context and the evolutionary distance between the sequences compared. Therefore, functional and experimental validation is often necessary to confirm the significance of sequence homology.

Molecular models are three-dimensional representations of molecular structures that are used in the field of molecular biology and chemistry to visualize and understand the spatial arrangement of atoms and bonds within a molecule. These models can be physical or computer-generated and allow researchers to study the shape, size, and behavior of molecules, which is crucial for understanding their function and interactions with other molecules.

Physical molecular models are often made up of balls (representing atoms) connected by rods or sticks (representing bonds). These models can be constructed manually using materials such as plastic or wooden balls and rods, or they can be created using 3D printing technology.

Computer-generated molecular models, on the other hand, are created using specialized software that allows researchers to visualize and manipulate molecular structures in three dimensions. These models can be used to simulate molecular interactions, predict molecular behavior, and design new drugs or chemicals with specific properties. Overall, molecular models play a critical role in advancing our understanding of molecular structures and their functions.

Nucleic acid hybridization is a process in molecular biology where two single-stranded nucleic acids (DNA, RNA) with complementary sequences pair together to form a double-stranded molecule through hydrogen bonding. The strands can be from the same type of nucleic acid or different types (i.e., DNA-RNA or DNA-cDNA). This process is commonly used in various laboratory techniques, such as Southern blotting, Northern blotting, polymerase chain reaction (PCR), and microarray analysis, to detect, isolate, and analyze specific nucleic acid sequences. The hybridization temperature and conditions are critical to ensure the specificity of the interaction between the two strands.

A phenotype is the physical or biochemical expression of an organism's genes, or the observable traits and characteristics resulting from the interaction of its genetic constitution (genotype) with environmental factors. These characteristics can include appearance, development, behavior, and resistance to disease, among others. Phenotypes can vary widely, even among individuals with identical genotypes, due to differences in environmental influences, gene expression, and genetic interactions.

Bacterial typing techniques are methods used to identify and differentiate bacterial strains or isolates based on their unique characteristics. These techniques are essential in epidemiological studies, infection control, and research to understand the transmission dynamics, virulence, and antibiotic resistance patterns of bacterial pathogens.

There are various bacterial typing techniques available, including:

1. **Bacteriophage Typing:** This method involves using bacteriophages (viruses that infect bacteria) to identify specific bacterial strains based on their susceptibility or resistance to particular phages.
2. **Serotyping:** It is a technique that differentiates bacterial strains based on the antigenic properties of their cell surface components, such as capsules, flagella, and somatic (O) and flagellar (H) antigens.
3. **Biochemical Testing:** This method uses biochemical reactions to identify specific metabolic pathways or enzymes present in bacterial strains, which can be used for differentiation. Commonly used tests include the catalase test, oxidase test, and various sugar fermentation tests.
4. **Molecular Typing Techniques:** These methods use genetic markers to identify and differentiate bacterial strains at the DNA level. Examples of molecular typing techniques include:
* **Pulsed-Field Gel Electrophoresis (PFGE):** This method uses restriction enzymes to digest bacterial DNA, followed by electrophoresis in an agarose gel under pulsed electrical fields. The resulting banding patterns are analyzed and compared to identify related strains.
* **Multilocus Sequence Typing (MLST):** It involves sequencing specific housekeeping genes to generate unique sequence types that can be used for strain identification and phylogenetic analysis.
* **Whole Genome Sequencing (WGS):** This method sequences the entire genome of a bacterial strain, providing the most detailed information on genetic variation and relatedness between strains. WGS data can be analyzed using various bioinformatics tools to identify single nucleotide polymorphisms (SNPs), gene deletions or insertions, and other genetic changes that can be used for strain differentiation.

These molecular typing techniques provide higher resolution than traditional methods, allowing for more accurate identification and comparison of bacterial strains. They are particularly useful in epidemiological investigations to track the spread of pathogens and identify outbreaks.

A cell line is a culture of cells that are grown in a laboratory for use in research. These cells are usually taken from a single cell or group of cells, and they are able to divide and grow continuously in the lab. Cell lines can come from many different sources, including animals, plants, and humans. They are often used in scientific research to study cellular processes, disease mechanisms, and to test new drugs or treatments. Some common types of human cell lines include HeLa cells (which come from a cancer patient named Henrietta Lacks), HEK293 cells (which come from embryonic kidney cells), and HUVEC cells (which come from umbilical vein endothelial cells). It is important to note that cell lines are not the same as primary cells, which are cells that are taken directly from a living organism and have not been grown in the lab.

Viral genes refer to the genetic material present in viruses that contains the information necessary for their replication and the production of viral proteins. In DNA viruses, the genetic material is composed of double-stranded or single-stranded DNA, while in RNA viruses, it is composed of single-stranded or double-stranded RNA.

Viral genes can be classified into three categories: early, late, and structural. Early genes encode proteins involved in the replication of the viral genome, modulation of host cell processes, and regulation of viral gene expression. Late genes encode structural proteins that make up the viral capsid or envelope. Some viruses also have structural genes that are expressed throughout their replication cycle.

Understanding the genetic makeup of viruses is crucial for developing antiviral therapies and vaccines. By targeting specific viral genes, researchers can develop drugs that inhibit viral replication and reduce the severity of viral infections. Additionally, knowledge of viral gene sequences can inform the development of vaccines that stimulate an immune response to specific viral proteins.

"Chickens" is a common term used to refer to the domesticated bird, Gallus gallus domesticus, which is widely raised for its eggs and meat. However, in medical terms, "chickens" is not a standard term with a specific definition. If you have any specific medical concern or question related to chickens, such as food safety or allergies, please provide more details so I can give a more accurate answer.

"Swine" is a common term used to refer to even-toed ungulates of the family Suidae, including domestic pigs and wild boars. However, in a medical context, "swine" often appears in the phrase "swine flu," which is a strain of influenza virus that typically infects pigs but can also cause illness in humans. The 2009 H1N1 pandemic was caused by a new strain of swine-origin influenza A virus, which was commonly referred to as "swine flu." It's important to note that this virus is not transmitted through eating cooked pork products; it spreads from person to person, mainly through respiratory droplets produced when an infected person coughs or sneezes.

Recombinant proteins are artificially created proteins produced through the use of recombinant DNA technology. This process involves combining DNA molecules from different sources to create a new set of genes that encode for a specific protein. The resulting recombinant protein can then be expressed, purified, and used for various applications in research, medicine, and industry.

Recombinant proteins are widely used in biomedical research to study protein function, structure, and interactions. They are also used in the development of diagnostic tests, vaccines, and therapeutic drugs. For example, recombinant insulin is a common treatment for diabetes, while recombinant human growth hormone is used to treat growth disorders.

The production of recombinant proteins typically involves the use of host cells, such as bacteria, yeast, or mammalian cells, which are engineered to express the desired protein. The host cells are transformed with a plasmid vector containing the gene of interest, along with regulatory elements that control its expression. Once the host cells are cultured and the protein is expressed, it can be purified using various chromatography techniques.

Overall, recombinant proteins have revolutionized many areas of biology and medicine, enabling researchers to study and manipulate proteins in ways that were previously impossible.

A Receiver Operating Characteristic (ROC) curve is a graphical representation used in medical decision-making and statistical analysis to illustrate the performance of a binary classifier system, such as a diagnostic test or a machine learning algorithm. It's a plot that shows the tradeoff between the true positive rate (sensitivity) and the false positive rate (1 - specificity) for different threshold settings.

The x-axis of an ROC curve represents the false positive rate (the proportion of negative cases incorrectly classified as positive), while the y-axis represents the true positive rate (the proportion of positive cases correctly classified as positive). Each point on the curve corresponds to a specific decision threshold, with higher points indicating better performance.

The area under the ROC curve (AUC) is a commonly used summary measure that reflects the overall performance of the classifier. An AUC value of 1 indicates perfect discrimination between positive and negative cases, while an AUC value of 0.5 suggests that the classifier performs no better than chance.

ROC curves are widely used in healthcare to evaluate diagnostic tests, predictive models, and screening tools for various medical conditions, helping clinicians make informed decisions about patient care based on the balance between sensitivity and specificity.

The Predictive Value of Tests, specifically the Positive Predictive Value (PPV) and Negative Predictive Value (NPV), are measures used in diagnostic tests to determine the probability that a positive or negative test result is correct.

Positive Predictive Value (PPV) is the proportion of patients with a positive test result who actually have the disease. It is calculated as the number of true positives divided by the total number of positive results (true positives + false positives). A higher PPV indicates that a positive test result is more likely to be a true positive, and therefore the disease is more likely to be present.

Negative Predictive Value (NPV) is the proportion of patients with a negative test result who do not have the disease. It is calculated as the number of true negatives divided by the total number of negative results (true negatives + false negatives). A higher NPV indicates that a negative test result is more likely to be a true negative, and therefore the disease is less likely to be present.

The predictive value of tests depends on the prevalence of the disease in the population being tested, as well as the sensitivity and specificity of the test. A test with high sensitivity and specificity will generally have higher predictive values than a test with low sensitivity and specificity. However, even a highly sensitive and specific test can have low predictive values if the prevalence of the disease is low in the population being tested.

Reproducibility of results in a medical context refers to the ability to obtain consistent and comparable findings when a particular experiment or study is repeated, either by the same researcher or by different researchers, following the same experimental protocol. It is an essential principle in scientific research that helps to ensure the validity and reliability of research findings.

In medical research, reproducibility of results is crucial for establishing the effectiveness and safety of new treatments, interventions, or diagnostic tools. It involves conducting well-designed studies with adequate sample sizes, appropriate statistical analyses, and transparent reporting of methods and findings to allow other researchers to replicate the study and confirm or refute the results.

The lack of reproducibility in medical research has become a significant concern in recent years, as several high-profile studies have failed to produce consistent findings when replicated by other researchers. This has led to increased scrutiny of research practices and a call for greater transparency, rigor, and standardization in the conduct and reporting of medical research.

Tertiary protein structure refers to the three-dimensional arrangement of all the elements (polypeptide chains) of a single protein molecule. It is the highest level of structural organization and results from interactions between various side chains (R groups) of the amino acids that make up the protein. These interactions, which include hydrogen bonds, ionic bonds, van der Waals forces, and disulfide bridges, give the protein its unique shape and stability, which in turn determines its function. The tertiary structure of a protein can be stabilized by various factors such as temperature, pH, and the presence of certain ions. Any changes in these factors can lead to denaturation, where the protein loses its tertiary structure and thus its function.

Organ specificity, in the context of immunology and toxicology, refers to the phenomenon where a substance (such as a drug or toxin) or an immune response primarily affects certain organs or tissues in the body. This can occur due to various reasons such as:

1. The presence of specific targets (like antigens in the case of an immune response or receptors in the case of drugs) that are more abundant in these organs.
2. The unique properties of certain cells or tissues that make them more susceptible to damage.
3. The way a substance is metabolized or cleared from the body, which can concentrate it in specific organs.

For example, in autoimmune diseases, organ specificity describes immune responses that are directed against antigens found only in certain organs, such as the thyroid gland in Hashimoto's disease. Similarly, some toxins or drugs may have a particular affinity for liver cells, leading to liver damage or specific drug interactions.

An Enzyme-Linked Immunosorbent Assay (ELISA) is a type of analytical biochemistry assay used to detect and quantify the presence of a substance, typically a protein or peptide, in a liquid sample. It takes its name from the enzyme-linked antibodies used in the assay.

In an ELISA, the sample is added to a well containing a surface that has been treated to capture the target substance. If the target substance is present in the sample, it will bind to the surface. Next, an enzyme-linked antibody specific to the target substance is added. This antibody will bind to the captured target substance if it is present. After washing away any unbound material, a substrate for the enzyme is added. If the enzyme is present due to its linkage to the antibody, it will catalyze a reaction that produces a detectable signal, such as a color change or fluorescence. The intensity of this signal is proportional to the amount of target substance present in the sample, allowing for quantification.

ELISAs are widely used in research and clinical settings to detect and measure various substances, including hormones, viruses, and bacteria. They offer high sensitivity, specificity, and reproducibility, making them a reliable choice for many applications.

An epitope is a specific region on the surface of an antigen (a molecule that can trigger an immune response) that is recognized by an antibody, B-cell receptor, or T-cell receptor. It is also commonly referred to as an antigenic determinant. Epitopes are typically composed of linear amino acid sequences or conformational structures made up of discontinuous amino acids in the antigen. They play a crucial role in the immune system's ability to differentiate between self and non-self molecules, leading to the targeted destruction of foreign substances like viruses and bacteria. Understanding epitopes is essential for developing vaccines, diagnostic tests, and immunotherapies.

A Structure-Activity Relationship (SAR) in the context of medicinal chemistry and pharmacology refers to the relationship between the chemical structure of a drug or molecule and its biological activity or effect on a target protein, cell, or organism. SAR studies aim to identify patterns and correlations between structural features of a compound and its ability to interact with a specific biological target, leading to a desired therapeutic response or undesired side effects.

By analyzing the SAR, researchers can optimize the chemical structure of lead compounds to enhance their potency, selectivity, safety, and pharmacokinetic properties, ultimately guiding the design and development of novel drugs with improved efficacy and reduced toxicity.

Deoxyribonucleic acid (DNA) is the genetic material present in the cells of organisms where it is responsible for the storage and transmission of hereditary information. DNA is a long molecule that consists of two strands coiled together to form a double helix. Each strand is made up of a series of four nucleotide bases - adenine (A), guanine (G), cytosine (C), and thymine (T) - that are linked together by phosphate and sugar groups. The sequence of these bases along the length of the molecule encodes genetic information, with A always pairing with T and C always pairing with G. This base-pairing allows for the replication and transcription of DNA, which are essential processes in the functioning and reproduction of all living organisms.

Recombinant fusion proteins are artificially created biomolecules that combine the functional domains or properties of two or more different proteins into a single protein entity. They are generated through recombinant DNA technology, where the genes encoding the desired protein domains are linked together and expressed as a single, chimeric gene in a host organism, such as bacteria, yeast, or mammalian cells.

The resulting fusion protein retains the functional properties of its individual constituent proteins, allowing for novel applications in research, diagnostics, and therapeutics. For instance, recombinant fusion proteins can be designed to enhance protein stability, solubility, or immunogenicity, making them valuable tools for studying protein-protein interactions, developing targeted therapies, or generating vaccines against infectious diseases or cancer.

Examples of recombinant fusion proteins include:

1. Etaglunatide (ABT-523): A soluble Fc fusion protein that combines the heavy chain fragment crystallizable region (Fc) of an immunoglobulin with the extracellular domain of the human interleukin-6 receptor (IL-6R). This fusion protein functions as a decoy receptor, neutralizing IL-6 and its downstream signaling pathways in rheumatoid arthritis.
2. Etanercept (Enbrel): A soluble TNF receptor p75 Fc fusion protein that binds to tumor necrosis factor-alpha (TNF-α) and inhibits its proinflammatory activity, making it a valuable therapeutic option for treating autoimmune diseases like rheumatoid arthritis, ankylosing spondylitis, and psoriasis.
3. Abatacept (Orencia): A fusion protein consisting of the extracellular domain of cytotoxic T-lymphocyte antigen 4 (CTLA-4) linked to the Fc region of an immunoglobulin, which downregulates T-cell activation and proliferation in autoimmune diseases like rheumatoid arthritis.
4. Belimumab (Benlysta): A monoclonal antibody that targets B-lymphocyte stimulator (BLyS) protein, preventing its interaction with the B-cell surface receptor and inhibiting B-cell activation in systemic lupus erythematosus (SLE).
5. Romiplostim (Nplate): A fusion protein consisting of a thrombopoietin receptor agonist peptide linked to an immunoglobulin Fc region, which stimulates platelet production in patients with chronic immune thrombocytopenia (ITP).
6. Darbepoetin alfa (Aranesp): A hyperglycosylated erythropoiesis-stimulating protein that functions as a longer-acting form of recombinant human erythropoietin, used to treat anemia in patients with chronic kidney disease or cancer.
7. Palivizumab (Synagis): A monoclonal antibody directed against the F protein of respiratory syncytial virus (RSV), which prevents RSV infection and is administered prophylactically to high-risk infants during the RSV season.
8. Ranibizumab (Lucentis): A recombinant humanized monoclonal antibody fragment that binds and inhibits vascular endothelial growth factor A (VEGF-A), used in the treatment of age-related macular degeneration, diabetic retinopathy, and other ocular disorders.
9. Cetuximab (Erbitux): A chimeric monoclonal antibody that binds to epidermal growth factor receptor (EGFR), used in the treatment of colorectal cancer and head and neck squamous cell carcinoma.
10. Adalimumab (Humira): A fully humanized monoclonal antibody that targets tumor necrosis factor-alpha (TNF-α), used in the treatment of various inflammatory diseases, including rheumatoid arthritis, psoriasis, and Crohn's disease.
11. Bevacizumab (Avastin): A recombinant humanized monoclonal antibody that binds to VEGF-A, used in the treatment of various cancers, including colorectal, lung, breast, and kidney cancer.
12. Trastuzumab (Herceptin): A humanized monoclonal antibody that targets HER2/neu receptor, used in the treatment of breast cancer.
13. Rituximab (Rituxan): A chimeric monoclonal antibody that binds to CD20 antigen on B cells, used in the treatment of non-Hodgkin's lymphoma and rheumatoid arthritis.
14. Palivizumab (Synagis): A humanized monoclonal antibody that binds to the F protein of respiratory syncytial virus, used in the prevention of respiratory syncytial virus infection in high-risk infants.
15. Infliximab (Remicade): A chimeric monoclonal antibody that targets TNF-α, used in the treatment of various inflammatory diseases, including Crohn's disease, ulcerative colitis, rheumatoid arthritis, and ankylosing spondylitis.
16. Natalizumab (Tysabri): A humanized monoclonal antibody that binds to α4β1 integrin, used in the treatment of multiple sclerosis and Crohn's disease.
17. Adalimumab (Humira): A fully human monoclonal antibody that targets TNF-α, used in the treatment of various inflammatory diseases, including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, and ulcerative colitis.
18. Golimumab (Simponi): A fully human monoclonal antibody that targets TNF-α, used in the treatment of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis.
19. Certolizumab pegol (Cimzia): A PEGylated Fab' fragment of a humanized monoclonal antibody that targets TNF-α, used in the treatment of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and Crohn's disease.
20. Ustekinumab (Stelara): A fully human monoclonal antibody that targets IL-12 and IL-23, used in the treatment of psoriasis, psoriatic arthritis, and Crohn's disease.
21. Secukinumab (Cosentyx): A fully human monoclonal antibody that targets IL-17A, used in the treatment of psoriasis, psoriatic arthritis, and ankylosing spondylitis.
22. Ixekizumab (Taltz): A fully human monoclonal antibody that targets IL-17A, used in the treatment of psoriasis and psoriatic arthritis.
23. Brodalumab (Siliq): A fully human monoclonal antibody that targets IL-17 receptor A, used in the treatment of psoriasis.
24. Sarilumab (Kevzara): A fully human monoclonal antibody that targets the IL-6 receptor, used in the treatment of rheumatoid arthritis.
25. Tocilizumab (Actemra): A humanized monoclonal antibody that targets the IL-6 receptor, used in the treatment of rheumatoid arthritis, systemic juvenile idiopathic arthritis, polyarticular juvenile idiopathic arthritis, giant cell arteritis, and chimeric antigen receptor T-cell-induced cytokine release syndrome.
26. Siltuximab (Sylvant): A chimeric monoclonal antibody that targets IL-6, used in the treatment of multicentric Castleman disease.
27. Satralizumab (Enspryng): A humanized monoclonal antibody that targets IL-6 receptor alpha, used in the treatment of neuromyelitis optica spectrum disorder.
28. Sirukumab (Plivensia): A human monoclonal antibody that targets IL-6, used in the treatment

Peptides are short chains of amino acid residues linked by covalent bonds, known as peptide bonds. They are formed when two or more amino acids are joined together through a condensation reaction, which results in the elimination of a water molecule and the formation of an amide bond between the carboxyl group of one amino acid and the amino group of another.

Peptides can vary in length from two to about fifty amino acids, and they are often classified based on their size. For example, dipeptides contain two amino acids, tripeptides contain three, and so on. Oligopeptides typically contain up to ten amino acids, while polypeptides can contain dozens or even hundreds of amino acids.

Peptides play many important roles in the body, including serving as hormones, neurotransmitters, enzymes, and antibiotics. They are also used in medical research and therapeutic applications, such as drug delivery and tissue engineering.

Monoclonal antibodies are a type of antibody that are identical because they are produced by a single clone of cells. They are laboratory-produced molecules that act like human antibodies in the immune system. They can be designed to attach to specific proteins found on the surface of cancer cells, making them useful for targeting and treating cancer. Monoclonal antibodies can also be used as a therapy for other diseases, such as autoimmune disorders and inflammatory conditions.

Monoclonal antibodies are produced by fusing a single type of immune cell, called a B cell, with a tumor cell to create a hybrid cell, or hybridoma. This hybrid cell is then able to replicate indefinitely, producing a large number of identical copies of the original antibody. These antibodies can be further modified and engineered to enhance their ability to bind to specific targets, increase their stability, and improve their effectiveness as therapeutic agents.

Monoclonal antibodies have several mechanisms of action in cancer therapy. They can directly kill cancer cells by binding to them and triggering an immune response. They can also block the signals that promote cancer growth and survival. Additionally, monoclonal antibodies can be used to deliver drugs or radiation directly to cancer cells, increasing the effectiveness of these treatments while minimizing their side effects on healthy tissues.

Monoclonal antibodies have become an important tool in modern medicine, with several approved for use in cancer therapy and other diseases. They are continuing to be studied and developed as a promising approach to treating a wide range of medical conditions.

Site-directed mutagenesis is a molecular biology technique used to introduce specific and targeted changes to a specific DNA sequence. This process involves creating a new variant of a gene or a specific region of interest within a DNA molecule by introducing a planned, deliberate change, or mutation, at a predetermined site within the DNA sequence.

The methodology typically involves the use of molecular tools such as PCR (polymerase chain reaction), restriction enzymes, and/or ligases to introduce the desired mutation(s) into a plasmid or other vector containing the target DNA sequence. The resulting modified DNA molecule can then be used to transform host cells, allowing for the production of large quantities of the mutated gene or protein for further study.

Site-directed mutagenesis is a valuable tool in basic research, drug discovery, and biotechnology applications where specific changes to a DNA sequence are required to understand gene function, investigate protein structure/function relationships, or engineer novel biological properties into existing genes or proteins.

... specificity can be looked at both from the perspective of the host i.e. how many different species of symbionts does the host ... how many different host species can a symbiont associate with (host specificity). There are two major approaches to determine ... In the field based approach specificity is assessed by determining the natural range of hosts or symbionts an organism ... Mandel, Mark J. (2010-11-01). "Models and approaches to dissect host-symbiont specificity". Trends in Microbiology. 18 (11): ...
2004). "Host specificity, plant communities". The European and North-American species of Sarcoscypha. Retrieved 2010-08-22. ... 2005). "[Purification and study of carbohydrate specificity of lectin from Sarcoscypha coccinea (Fr.) Lambette]". Ukrainskii ...
How to measure host specificity. Vie et Milieu (Life and Environment) 58, 121-124. 2010 Marine parasite diversity and ... In: S Morand and B Krasnov (eds.). The Biogeography of Host-Parasite Interactions. Oxford University Press, pp. 73-88. ...
Hernandez-Bello, M.A.; M. I. Chilvers; H. Akamatsu; T. L. Peever (2006). "Host Specificity of Ascochyta spp. Infecting Legumes ... These can also overwinter in infected plant debris and release their ascospores in the spring to infect new hosts as primary ... That is, each species only causes symptoms on their respective hosts and not on another. Areas where rainfall and/or high ... The asexual conidia travel short distances to new hosts via water splashes from rain.[citation needed] Crop rotation: Since ...
It has low host specificity. Captive fish are especially susceptible due to the confined space of aquariums and accumulation of ... Symbiotic relationships with host plants also allow for improved growth performance and plant survival rate in drought ...
Steward, J. S. (1 July 1947). "Host-parasite specificity in Coccidia; infection of the chicken with the turkey coccidium, ...
Host Specificity in Plant Diseases. Vol. 1: Prokaryotes (1st ed.). Amsterdam: Elsevier Science. ISBN 978-0-08-098473-5. Satola ...
Yan, Z. (1990). Host Specificity of Lysiana exocarpi subsp. exocarpi and Other Mistletoes in Southern South Australia. ... No host species were herbaceous. Every host family and genus recorded contained species which were not documented as mistletoe ... Seven mistletoe species commonly parasitised exotic host species including L. exocarpi. The commonly recorded exotic host ... Attachment to the host plant is by means of one or more woody absorbing organs (haustoria). This organ effectively replaces the ...
Hence their host specificity is uncertain. Cullenia exarillata "BioLib: Biological library". www.biolib.cz. U'Ren, Jana M.; ... It is assumed to be host-specific, however it has been recorded growing on and Inga sp. fruits which is a Legume. ... The species grows on fruits and seeds are generally considered as host-specific. This species was collected from Sri Lanka ...
Larval feeding behaviour and host specificity. Can Entomol 105:985-990 Howard, Russell "Insects and Arthropods" Diagnostic ... Once the host worm begins to decompose and is no longer useful to the larvae, the larvae can either leave to find another host ... If a first instar larva decides to move to another host, it must penetrate its new host quickly in order to survive. Towards ... It is important that they find their host quickly, because larvae must penetrate a worm within three days in order to survive. ...
The presence of heterophyid infection in humans is generally caused by a lack of host specificity by the parasites, as seen in ... "Classification and host specificity of Metagonimus spp. from Korean freshwater fish." Korean Journal of Parasitology. Vol. 34: ... Definitive hosts include humans and various fish-eating mammals, primarily dogs, cats, and pigs. Fish-eating birds may also be ... One is to control the intermediate host (snails). This can be done through use of molluscidals. Another is to use education to ...
2016). "Host specificity of Asian Chrysochus Chevr. in Dej. (Coleoptera, Chrysomelidae: Eumolpinae) and their potential use for ...
Beaver, R. A. (September 1979). "Host specificity of temperate and tropical animals". Nature. 281 (5727): 139-141. Bibcode: ...
He also examined host specificity of species. Hale found that there are different communities at the base of the tree compared ...
Generally, high host specificity exists among lagoviruses. Classic RHDVa only affects European rabbits, a species native to ...
and its nodule isolates Azorhizobium johannae with other legume hosts and rhizobia. I." (PDF). Symbiosis. 36: 57-68. Moreira FM ... Gonçalves M, Moreira FM (2004). "Specificity of the legume Sesbania virgata (Caz.) Pers. ...
Host specificity is not yet fully understood. Originally pathovar groups were documented according to the hosts from which they ... Important host families and species economically affected include: There are also many significant hosts for D. dadantii ... dadantii can survive in potting media with or without a host plant for a year or more and in the leaves of host or nonhost ... The host range of D. dadantii continues growing as new susceptible species are continuously being documented. It has also been ...
... species vary in their host specificity. This can lead to nontarget hosts being parasitized. This, in turn, can ... To locate host eggs, adult females use chemical and visual signals, such as egg shape and colour. After she finds a suitable ... In addition, some hosts can evolve with a dependency on Wolbachia for core reproductive functions, such as oogenesis, so that ... A single female can parasitize up to 10 host eggs a day. Trichogramma wasps are small and very uniform in structure, which ...
Kistler HC (2001). "Evolution of host specificity in Fusarium oxysporum". In Nelson PE, Summerell BA (eds.). Fusarium: Paul E. ... The host range of these fungi is broad and includes animals, ranging from arthropods to humans, as well as plants, including a ... Because the hosts of a given forma specialis usually are closely related, many have assumed that members of a forma specialis ... In this case, any further changes in the host or parasite could disturb the relationship, in a way that fungal activities or a ...
Dussoix, D.; Arber, W. (1965). "Host specificity of DNA produced by Escherichia coli. IV. Host specificity of infectious DNA ... Arber, W.; Dussoix, D. (1962). "Host specificity of DNA produced by Escherichia coli. I. Host controlled modification of ... Arber W, Dussoix D (1962). "Host specificity of DNA produced by Escherichia coli: I. Host controlled modification of ... Arber, Werner; Dussoix, Daisy (1962). "Host specificity of DNA produced by Escherichia coli. I. Host controlled modification of ...
Novotny, V.; Basset, Y. (7 June 2005). "Host specificity of insect herbivores in tropical forests". Proceedings of the Royal ... L is the average infection time of the host, and S is the density of the host population. By decreasing any one of the ... This is an example of "the enemy of my enemy is my friend" and it has been shown that the potential of host-specific insects to ... Through these observations, Connell suggests that each tree species has host-specific enemies that attack it and any of its ...
Dussoix D, Arber W (July 1962). "Host specificity of DNA produced by Escherichia coli. II. Control over acceptance of DNA from ... The host cell, in this example E. coli K, is known as the restricting host and appears to have the ability to reduce the ... are a powerful tool for host genome editing due to their enhanced sequence specificity. ZFN work in pairs, their dimerization ... HsdM is necessary for adding methyl groups to host DNA (methyltransferase activity), and HsdS is important for specificity of ...
Heed, William B. (1971). "Host Plant Specificity and Speciation in Hawaiian Drosophila". Taxon. 20 (1): 115-121. doi:10.2307/ ... The major ancestral host plant for members of plantibia subgroup is Clermontia, with derived species like D. silvestris ... Feral pigs, goats, and other mammals will eat host plants like Clermontia and trample on terrain, threatening the habitat and ... D. silvestris females deposit their eggs on the decaying or fermenting bark of principal host plant Clermontia, a large, ...
... a novel virophage with Mimiviridae host specificity". PLOS ONE. 9 (4): e94923. Bibcode:2014PLoSO...994923G. doi:10.1371/journal ... Amoeba and other protists serve as natural hosts. The family is divided in up to 4 subfamilies. Viruses in this family belong ... Amoeba serve as the natural host. Within the genome of Lentille virus integrated genome of a virophage (Sputnik 2) and a ... However, the mimivirus Cafeteria roenbergensis virus was isolated and partially characterized in 1995, although the host was ...
Munshi, G.H.; & Moiz, S.A. (1967). Host plant specificity of the black swallowtail butterfly. Polydorus aristolochiae ( ...
Morphometric correlates of host specificity in Dactylogyrus species (Monogenea) parasites of European Cyprinid fish. ... However, the degree of host specificity varies strongly. Thus, Toxoplasma (Protista) infects numerous vertebrates including ... Many congeners (species belonging to the same genus) and non-congeners were found on single host species. The maximum number of ... For example, there is no universal parasite which infects all host species and microhabitats within or on them. ...
These specialists demonstrate high levels of specificity for their host species and may form physiologically adapted host-races ... Leuchtmann, A. (1992). "Systematics, distribution and host specificity of grass endophytes". Nat. Toxins. 1 (3): 150-162. doi: ... fungi that are closely associated with their hosts have transferred genes for secondary metabolite production to the host ... The fungal hyphae penetrates the host plant's embryo and grows along the seeds to infect the new plants that will grow from the ...
"Host specificity in spinturnicid mites: do parasites share a long evolutionary history with their host?". Journal of Zoological ... Their selection of host tends to align with the host species that lives closest to their local environment. Spinturnix mites ... July 2007). "Host sex and ectoparasites choice: preference for, and higher survival on female hosts". The Journal of Animal ... Spinturnix mites are a host specific species, meaning they have a few major host species that they prefer, as well as a few ...
The different species of Brucella are genetically very similar, although each has a slightly different host specificity. Hence ... They are intracellular within the host organism, and show environmental persistence outside the host. The intracellular ... The specificity was >99%. In a study including 75 patients with brucellosis, five patients with positive ELISA had a negative ... They infect many species, but with some specificity. The Brucella species belongs to the Rhizobiales group, in the ...
DUSSOIX D, ARBER W (1962). "Host specificity of DNA produced by Escherichia coli. II. Control over acceptance of DNA from ... The restriction modification systems in N. meningitidis vary in specificity between different clades. This specificity provides ... ZFNs are a powerful tool for host genome editing due to their enhanced sequence specificity. ZFN work in pairs, their ... Luria SE (1953). "Host-induced modifications of viruses". Cold Spring Harb. Symp. Quant. Biol. 18: 237-44. doi:10.1101/sqb. ...
Heiniger, U., & Frey, W. (1995). Host specificity of Gremmeniella abietina. In P. Capretti, U. Heiniger, & R. Stephan (Eds.), ... 3 to 7 septa were abundant with a slight maximum of 3 septate spores independent of the host or site. ...
Host Specificity and Regional Endemicity in Symbiotic Dinoflagellates (Symbiodinium, Dinophyta) Associated with Sea Anemones in ... Recent investigations of coral reef biology have focused on the global biogeography and host specificity of Symbiodinium, a ... One suitable system to investigate Symbiodinium population genetics of a single host across a global range is the facultatively ... In order to determined the specificity and population genetic structure of Symbiodinium communities associated with Aiptasia ...
Host Specificity and Regional Endemicity in Symbiotic Dinoflagellates (Symbiodinium, Dinophyta) Associated with Sea Anemones in ... Recent investigations of coral reef biology have focused on the global biogeography and host specificity of Symbiodinium, a ... One suitable system to investigate Symbiodinium population genetics of a single host across a global range is the facultatively ... In order to determined the specificity and population genetic structure of Symbiodinium communities associated with Aiptasia ...
Keywords: Tamarix, Diorhabda, biological control, host specificity, ecological host range, fundamental host range, climatic ... The host specificity of Diorhabda carinulata was tested in open-field multichoice tests as well as laboratory-based choice and ... An alternative biological agent with a higher host specificity and greater environmental suitability should be sought for ... Open-field host choice tests and outdoor, caged multi-choice tests were conducted in Western Colorado, USA using native and ...
... host ranges of these parasitoids. We present the results of the first retrospective host-specificity study on T. basalis in New ... Retrospective host-specificity testing shows Trissolcus basalis (Wollaston) and the native Trissolcus oenone (Dodd) ( ... while development times were similar for both parasitoids regardless of host. We discuss the importance of physiological host ... Retrospective host range testing is essential for understanding the physiological host range of introduced biological control ...
... specificity can be looked at both from the perspective of the host i.e. how many different species of symbionts does the host ... how many different host species can a symbiont associate with (host specificity). There are two major approaches to determine ... In the field based approach specificity is assessed by determining the natural range of hosts or symbionts an organism ... Mandel, Mark J. (2010-11-01). "Models and approaches to dissect host-symbiont specificity". Trends in Microbiology. 18 (11): ...
morsprunorum of Differing Host Specificity and Virulence * Susanne E. Zamze1,†, A. R. W. Smith1, R. C. Hignett2 ... Crosse J. E., Garrett C. M. E. 1970; Pathogenicity of Pseudomonas morsprunorum in relation to host specificity. Journal of ... Composition of lipopolysaccharide from Pseudomonas morsprunorum strains of differing host specificity and virulence. Society ... morsprunorum of Differing Host Specificity and Virulence. Microbiology 131, 1941 (1985); https://doi.org/10.1099/00221287-131-8 ...
Selected quality suppliers for anti-Dual Specificity Phosphatase 3 antibodies. ... Order monoclonal and polyclonal Dual Specificity Phosphatase 3 antibodies for many applications. ... Dual Specificity Phosphatase 3 Antibodies by Host. Find Dual Specificity Phosphatase 3 Antibodies with a specific Host. The ... Dual Specificity Phosphatase 3 Antibodies by Binding Specificity. Find Dual Specificity Phosphatase 3 Antibodies with a ...
Here, clues are provided as to how differences in specificity come about. The genomes of two Fusarium fungi with differing host ... While some species have a wide host range, others are more selective. Comparative genomics of three Fusarium fungi with broad ... These findings shed light on the evolution of host range and pathogenicity. Fungi from the genus Fusarium are important ... Some have a wide host range, whereas others are more specific in the organisms they infect. ...
The parasite has been found in a perplexing array of hosts, but some host specificity has been observed. When it comes to ... host specificity, parasite-host-microbiome interaction, etc.), issues have emerged when it comes quality-controlling DNA ... Labels: Blastocystis, diagnosis, dogs, host specificity, IBS, PCR, pets, real-time PCR, ST10, STS primers, subtypes ... Labels: animals, Blastocystis, Blastocystis hominis, host specificity, IBS, India, macaque, subtype, subtypes, Treatment ...
See other pages where Nodulation host specificity is mentioned: [Pg.85] [Pg.85] [Pg.105] [Pg.208] [Pg.210] [Pg.307] [Pg.307] [ ... Nodulation host specificity. Z. Banfalvi and A. Kondorosi, Production of root hair deformation factors by Rhizohium meliloti ... Spaink, H.P. et al., Rhizobium nodulation gene nodD as a determinant of host specificity, Nature, 328, 337, 1987. [Pg.437]. ... A central domain of Rhizobium NodE protein mediates host specificity by determining the hydropho-bicity of fatty acyl moieties ...
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RCSB PDB (citation) is hosted by. RCSB PDB is a member of the ... assessing specificity and affinity.. Rutenber, E.E., Stroud, R. ... BINDING OF THE ANTICANCER DRUG ZD1694 TO E. COLI THYMIDYLATE SYNTHASE: ASSESSING SPECIFICITY AND AFFINITY. *PDB DOI: https:// ...
Host species. Human. * Specificity. Not suitable for ICC/IF.. * Tested applications. Suitable for: IHC-P, WBmore details. ...
Host species. Mouse. * Specificity. Reacts with NP of all influenza A viruses so far tested, including seasonal H2N2, H3N2(A/ ... single cell analysis of pandemic influenza A virus infection in the human airways uncovers cell-type specific host ...
Host species. Donkey. * Target species. Rabbit. * Specificity. Recognizes rabbit IgG, H&L. X-Adsorbed and exhibits minimal ...
Host: Mouse. Antibody Format: Whole IgG. Specificity: IgG, F(ab)â‚‚ fragment specific. Minimal Cross Reactivity: Bovine, Horse, ...
Host: Goat. Antibody Format: Whole IgG. Specificity: IgG (H+L). Minimal Cross Reactivity: Human, Bovine, Horse, Rabbit, Rat ...
Rat Dual Specificity Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) ELISA Kit. Cat# MBS9933460. Supplier: MyBiosource. ... MBS9933460 , Rat Dual Specificity Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) ELISA Kit. (No reviews yet) Write a Review ... Host: N/A. Reactivity: Rat. Specificity: N/A. Purity: N/A. Form: N/A ... MBS9933460 , Rat Dual Specificity Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) ELISA Kit ...
Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing A study in Nature suggests epitope editing in ... Researchers Develop Simoa-based Assay for Dengue Fever Host Immune Response Feb 20, 2015 , staff reporter ... may allow more sensitive detection of the host immune response to dengue fever than other current methods. ...
These findings, taken together with lack of phylogenetic association to host, suggest that the HEV host specificity is a ... Genetic host specificity of hepatitis E vi... [Infect Genet Evol. 2014] - PubMed - NCBI. Infect Genet Evol. 2014 Mar 22. pii: ... Genetic host specificity of hepatitis E virus.. Lara J1, Purdy MA2, Khudyakov YE2. ... Genetic host specificity of hepatitis E vi... [Infect Genet Evol. 2014] - PubMed - NCBI ...
Dive into the research topics of Host specificity of the gut microbiome. Together they form a unique fingerprint. ...
Call for Proposals to Host FORCE11 Annual Conference FORCE11 Admin 15 Jul 2023 No Comments ... Study shows scientific reproducibility is hampered by lack of specificity of resources. ...
Inflammation-associated enterotypes, host genotype, cage and inter-individual effects drive gut microbiota variation in common ...
Host specificity of the gut microbiome.. Mallott, Elizabeth K; Amato, Katherine R. Nat Rev Microbiol ; 19(10): 639-653, 2021 10 ... Phylosymbiosis, or patterns of microbiome composition that can be predicted by host phylogeny, is a unique framework for ... We also note that despite hosting rich microbiomes, mammals commonly exhibit phylosymbiosis. We hypothesize that this pattern ... Developing general principles of host-microorganism interactions necessitates a robust understanding of the eco-evolutionary ...
A seven-gene region with a host association signal was found. Genes in this region were almost universally present in cattle ... Phylogenetic analysis implied frequent host switching but also showed that some lineages were strongly associated with ... from cattle were better able to grow in vitamin B5-depleted media and propose that this difference may be an adaptation to host ... the factors responsible for adaptation to cattle and chickens among 192 Campylobacter isolates from these and other host ...
In particular, host specificity, host-finding capacity, and prey behavior are important factors that should be evaluated. ... In particular, host specificity, host-finding capacity, and prey behavior are important factors that should be evaluated. ... The tests on parasitoid host specificity include studies on chemical ecology. In this regard, we investigated and compared the ... The tests on parasitoid host specificity include studies on chemical ecology. In this regard, we investigated and compared the ...
Host Specificity * Papillomaviridae / classification* * Papillomaviridae / genetics* Grants and funding * Wellcome Trust/United ... Despite a long co-evolutionary history with their hosts, some papillomaviruses are pathogens of their natural host species. ...
Psst! Create a DigitalOcean account and get $200 in free credit for cloud-based hosting and services. ... In such a stylesheet, since the specificity of the rules also corresponds to the source order or the rules, specificity is ... While its not possible to simply instruct the browser to ignore specificity altogether, it is possible to prevent specificity ... Do We Actually Need Specificity In CSS? Chris Coyier on Nov 4, 2015 ...
  • The host specificity of Diorhabda carinulata was tested in open-field multichoice tests as well as laboratory-based choice and no-choice tests using invasive target Tamarix species as well as the indigenous non-target T. usneoides. (wits.ac.za)
  • We conducted no-choice oviposition tests between the two resident Trissolcus species and all available New Zealand pentatomid species to characterise the physiological (=fundamental) host ranges of these parasitoids. (stanford.edu)
  • In a symbiosis between a larger organism such as a plant or an animal (called host) and a microorganism (called symbiont) specificity can be looked at both from the perspective of the host i.e. how many different species of symbionts does the host associate with (symbiont specificity), as well as from the perspective of the symbiont i.e. how many different host species can a symbiont associate with (host specificity). (wikipedia.org)
  • Find Dual Specificity Phosphatase 3 Antibodies for a variety of species such as anti-Human Dual Specificity Phosphatase 3, anti-Mouse Dual Specificity Phosphatase 3, anti-Rat Dual Specificity Phosphatase 3. (antibodies-online.com)
  • Some species, such as F. graminearum ( Fg ) and F . verticillioides ( Fv ), have a narrow host range, infecting predominantly the cereals ( Fig. 1a ). (nature.com)
  • Aside from their differences in host adaptation and specificity, Fusarium species also vary in reproductive strategy. (nature.com)
  • It is a characteristic of the rhizobium-legume symbiosis that the bacteria exhibit great specificity in their choice of host, indeed the genus Rhizobium is divided into species on the ability of the strain to form nodules in specific plant species (Table 6.1). (chempedia.info)
  • Therefore, a choice test to determine host-finding capacity was performed on Ganaspis brasiliensis, which is a larval parasitoid of another important invasive species, Drosophila suzukii. (unitn.it)
  • Despite a long co-evolutionary history with their hosts, some papillomaviruses are pathogens of their natural host species. (nih.gov)
  • The immunology of enzyme inhibitors synthesized in the host cells are summarized in this article, with case studies in mammal species, insect species, plant species. (natural-foundation-science.org)
  • SCIN infects a broad range of animal species, including horses, humans, pigs, which is evolved into strong adaptiveness through genome modification (such as by gene communications with external genetic segments aiming to host-invasion interactions). (natural-foundation-science.org)
  • We suggest using a phylogenetic framework of pathogens and their infected host species for insight into which animals may serve as reservoirs. (springer.com)
  • When scant information is available about a novel emerging virus, understanding it within a framework of evolutionary relationships can help characterize it in the context of its most closely related species and their known hosts and vectors. (springer.com)
  • In previous studies on marine algae, these symbioses range from innocuous to pathogenic depending on the host and endophyte species. (degruyter.com)
  • These specialized antibodies are tailored for various scientific applications like WB, ELISA, FACS, IHC, IF (cc), providing you with options like polyclonal, recombinant, and monoclonal antibodies, sourced from different host species such as Rabbit. (antibodies-online.com)
  • Host plants are restricted to Macadamia species, with Macadamia integrifolia Maiden & Betche (Proteaceae) being grown in Hawaii for nut production. (bvsalud.org)
  • These findings, taken together with lack of phylogenetic association to host, suggest that the HEV host specificity is a heritable and convergent phenotypic trait achievable through variety of genetic pathways (abundance), and explain a broad host range for HEV3 and HEV4. (blogspot.com)
  • Phylogenetic analysis implied frequent host switching but also showed that some lineages were strongly associated with particular hosts. (ox.ac.uk)
  • The second use of phylogenetic information, and our focus, is to predict relationships among pathogens and their hosts and/or vectors. (springer.com)
  • Albrecht, C., Geurts, R. and Bisseling, T. (1999) Legume nodulation and mycorrhizae formation two extremes in host specificity meet. (chempedia.info)
  • However, between 1930to 1940 several studies demonstrated that only certain strains of Rhizobium induce nodules on specific legume hosts. (chempedia.info)
  • The Rhizobium-legume symbiosis , an interaction between a prokaryote (Rhizobium) and a eukaryote (legume), requires a series of sequential induction and function of both bacterium-encoded (bac-teroidins) and host-encoded (nodulins) nodule- specific proteins . (chempedia.info)
  • Genome-wide association study identifies vitamin B5 biosynthesis as a host specificity factor in Campylobacter. (ox.ac.uk)
  • Transfer of LS chromosomes between otherwise genetically isolated strains explains the polyphyletic origin of host specificity and the emergence of new pathogenic lineages in F. oxysporum . (nature.com)
  • BN models for individual proteins and domains of the nonstructural polyprotein detected the host origin of HEV strains with accuracy of 74-93% and 63-87%, respectively. (blogspot.com)
  • These structural proteins are important to determine host range and tropism, and they play a crucial role in delivering the RNA genome into the cytoplasm of new host cells. (medscape.com)
  • Specificity in symbiosis refers to the taxonomic range with which an organism associates in a symbiosis. (wikipedia.org)
  • It has an estabUshment of a host-specific symbiosis between legumes, and their rhizobia were determined in plants (Cohn et al. (chempedia.info)
  • One suitable system to investigate Symbiodinium population genetics of a single host across a global range is the facultatively symbiotic anemone Aiptasia. (auburn.edu)
  • We tested the physiological host ranges of an introduced biocontrol agent (T. basalis) and native parasitoid (T. oenone). (stanford.edu)
  • The host-parasitoid complex between New Zealand pentatomids, T. basalis , and the native pentatomid parasitoid Trissolcus oenone Dodd, is therefore poorly understood. (stanford.edu)
  • The tests on parasitoid host specificity include studies on chemical ecology. (unitn.it)
  • When host specificity testing is complete, Maori, community and interest groups will be engaged and, an application to release the parasitoid from containment will be submitted to the Environmental Protection Authority in 2018. (nzffa.org.nz)
  • Parasitoid emergence from the control (MFC) averaged 30.2% compared to 0% on non-target hosts. (bvsalud.org)
  • We report on the parasitoid performance in native Australia, rearing biology, host specificity testing, and the extant natural enemies associated with MFC in Hawaii. (bvsalud.org)
  • The relevance of HEV genetic diversity to host adaptation is poorly understood. (blogspot.com)
  • We applied our association mapping method to identify the factors responsible for adaptation to cattle and chickens among 192 Campylobacter isolates from these and other host sources. (ox.ac.uk)
  • We found that isolates from cattle were better able to grow in vitamin B5-depleted media and propose that this difference may be an adaptation to host diet. (ox.ac.uk)
  • An advantage and disadvantage of monoclonal antibodies reside in their specificity. (forbes.com)
  • Molecular isolation of these genes will enable study of the molecular interaction between pathogen effector and host resistance genes. (edu.sa)
  • Some of the molecules Legionella injects into a microbial or mammalian eukaryotic host cell are called "effector proteins. (huffpost.com)
  • Effector proteins alter control of host cell biology by changing control and signaling pathways and thus restructuring the cytoskeleton that organizes the interior of the cell. (huffpost.com)
  • The presence of eukaryotic domains in these effector proteins indicates that Legionella acquired them from eukaryotic hosts, most probably their amoebal and other microbial hosts. (huffpost.com)
  • Developing general principles of host-microorganism interactions necessitates a robust understanding of the eco-evolutionary processes that structure microbiota . (bvsalud.org)
  • Elucidation of the mechanisms that distinguish between homeostatic and pathogenic microbiota-host interactions could identify therapeutic targets for preventing or modulating inflammatory diseases and for boosting the efficacy of cancer immunotherapy. (nature.com)
  • We employed a Bayesian network (BN) analysis of HEV3 and HEV4 to detect epistatic connectivity among protein sites and its association with the host specificity in each genotype. (blogspot.com)
  • Find available monoclonal or polyclonal Dual Specificity Phosphatase 3 Antibodies. (antibodies-online.com)
  • Phylosymbiosis, or patterns of microbiome composition that can be predicted by host phylogeny , is a unique framework for interrogating these processes. (bvsalud.org)
  • Open-field host choice tests and outdoor, caged multi-choice tests were conducted in Western Colorado, USA using native and invasive Tamarix material imported from South Africa, identified using molecular genotyping. (wits.ac.za)
  • Expect important and potentially game-changing updates on host-pathogen interactions, cell biology and evolution, epidemiology, intestinal ecology, diagnosis and molecular characterisation. (blastocystis.net)
  • In this study, molecular mechanisms underlying the sequence diversification-enabled HopZ1 allelic specificity is investigated. (uea.ac.uk)
  • The specificity of host-pathogen interactions with emphasis on the specific i. (natural-foundation-science.org)
  • 2021). Article 14: The specificity of host-pathogen interactions with emphasis on the specific inhibitor enzyme synthesized in the invasion-defense process. (natural-foundation-science.org)
  • While this situation is one of the things that stimulate research (genetic diversity, co-evolution, host specificity, parasite-host-microbiome interaction, etc.), issues have emerged when it comes quality-controlling DNA sequences and putting taxonomic identifiers on these sequences. (blastocystis.net)
  • The present study further assessed a pathogenic relationship between filamentous algal endophytes and a red algal host from the western Antarctic Peninsula. (degruyter.com)
  • Successful infection proceeds simultaneously with nodule morphogenesis triggered by the signal compounds produced by Rhizobium in response to its host, and leads to the release of bacteria from the infection threads into the cortical cells . (chempedia.info)
  • Figure 3: LPS of gram-negative bacteria activates host innate immune responses. (europeanpharmaceuticalreview.com)
  • This blog will present some of the evidence for horizontal transfer in the reverse direction: DNA acquisition by infectious bacteria from eukaryotic hosts. (huffpost.com)
  • Bacteria take control of eukaryotic cells by injecting regulatory proteins into their hosts. (huffpost.com)
  • Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. (antibodies-online.com)
  • It plays an important role in the onset of localized AgP because of its virulence factors, such as RTX leukotoxin and cytolethal distending toxin, which triggerimmunological host responses activating osteoclastogenesis and leading to tissue breakdown 9 . (bvsalud.org)
  • However, viral evolution, spillover events, or changes in hosts can turn seemingly unimportant viruses into biosecurity threats or public health emergencies. (springer.com)
  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. (antibodies-online.com)
  • viciae NodO protein compensates for the exported signal made by the host-specific nodulation genes. (chempedia.info)
  • A central domain of Rhizobium NodE protein mediates host specificity by determining the hydropho-bicity of fatty acyl moieties of nodulation factors . (chempedia.info)
  • S. R. Long, In vitro sulfotransferase activity of NodH, a nodulation protein of Rhizobium meliloti required for host-specific nodulation. (chempedia.info)
  • Unique aspects of the cell surface polysaccharide of Pseudomonas phaseolicola as demonstrated by bacteriophage specificity. (microbiologyresearch.org)
  • Pathogenicity of Pseudomonas morsprunorum in relation to host specificity. (microbiologyresearch.org)
  • Parasitism efficiencies for all treatments exceeded 60%, while development times were similar for both parasitoids regardless of host. (stanford.edu)
  • Eadya parasitoids were most likely to survive to pupation if their beetle larva hosts were large at prepupation. (nzffa.org.nz)
  • The effect of nutrition and body size of host beetle larvae on successful rearing of the Eadya parasitoids comes just in time. (nzffa.org.nz)
  • Exploration in Australia started in November 2013 for the evaluation of potential parasitoids being host specific for introduction into Hawaii. (bvsalud.org)
  • There are two major approaches to determine specificity, the field based (ecological) approach and the physiological (experimental) approach. (wikipedia.org)
  • Retrospective host-specificity testing shows Trissolcus basalis (Wollaston) and the native Trissolcus oenone (Dodd) (Hymenoptera: Scelionidae) have overlapping physiological host ranges in New Zealand. (stanford.edu)
  • NEW YORK (GenomeWeb) - A team from Tufts University has published a proof of concept demonstrating that Quanterix's digital ELISA technology, Simoa, may allow more sensitive detection of the host immune response to dengue fever than other current methods. (genomeweb.com)
  • Here we show that two wheat resistance genes, Rwt3 and Rwt4, acting as host-specificity barriers against non-Triticum blast pathotypes encode a nucleotide-binding leucine-rich repeat immune receptor and a tandem kinase, respectively. (edu.sa)
  • Clearly, the injected proteins have to be able to interact in very specific ways with molecules in the host cell's control circuitry. (huffpost.com)
  • Z. Banfalvi and A. Kondorosi, Production of root hair deformation factors by Rhizohium meliloti nodulation genes in Escherichia coli H.mD (NocM) is involved in the plant host -specific modification of the NodABS-factor. (chempedia.info)
  • Host-specific regulation of nodulation genes in Rhizobium is mediated by a plant-signal interacting with the nodD gene product. (chempedia.info)
  • The objectives of this study were to understand the meanings attributed by workers in relation to the hosting of crack users at CAPS ad (Centro de Atenção Psicossocial) in the interior of Bahia, and to identify what actions workers developed in relation to this hosting. (bvsalud.org)
  • Find Dual Specificity Phosphatase 3 Antibodies validated for a specific application such as WB, ELISA, IHC, IF (cc). (antibodies-online.com)
  • Find Dual Specificity Phosphatase 3 Antibodies with a specific Host. (antibodies-online.com)
  • Find Dual Specificity Phosphatase 3 Antibodies with a specific conjugate such as Biotin, FITC, HRP. (antibodies-online.com)
  • Find KCNH2 Antibodies with a specific Host. (antibodies-online.com)
  • They target specific surface structures and either eliminate the virus from the host bloodstream or destroy the infected cell in which it resides. (forbes.com)
  • The answer is that Legionella takes the specific information from its hosts. (huffpost.com)
  • Results indicated that M. macadamiae is host specific to MFC. (bvsalud.org)
  • We also note that despite hosting rich microbiomes , mammals commonly exhibit phylosymbiosis. (bvsalud.org)
  • Biology and host specificity testing were conducted at the Hawaii Department of Agriculture, Insect Containment Facility on nine Hemipteran and three Lepidopteran eggs. (bvsalud.org)
  • There has been no evidence of parasitism or host feeding on any of the non-target insect hosts that were tested. (bvsalud.org)
  • We present the results of the first retrospective host-specificity study on T. basalis in New Zealand. (stanford.edu)
  • The economic importance of nitrogen-fixation by leguminous plants has led to extensive study of the process of nodulation and in particular the nature of the host specificity of Rhizobium. (chempedia.info)
  • To determine if host plant abundance determined the size of clover root weevil (CRW) Sitona obsoletus larval populations, a study was conducted over 4 years in plots sown in ryegrass ( Lolium perenne ) (cv. (frontiersin.org)
  • Trissolcus basalis Wollaston was released in New Zealand in 1949 against green vegetable bug (Nezara viridula [L.]), but host range testing was never undertaken, and subsequent work in the 1960s was only of a qualitative nature and remains incomplete. (stanford.edu)
  • Retrospective host range testing is essential for understanding the physiological host range of introduced biological control agents (BCAs) and updating forecasts of non-target risks. (stanford.edu)
  • We discuss the importance of physiological host range testing for understanding potential non-target effects. (stanford.edu)
  • In this Review , we summarize the prevalence of phylosymbiosis across the animal kingdom on the basis of the current literature and explore the microbial community assembly processes and related host traits that contribute to phylosymbiosis. (bvsalud.org)
  • Further host specificity testing on more non-target beetles is the plan for this summer. (nzffa.org.nz)
  • In addition, the isolation of virophages has led us to discover previously unknown features displayed by their host viruses and cells. (mdpi.com)
  • In the field based approach specificity is assessed by determining the natural range of hosts or symbionts an organism associates with. (wikipedia.org)
  • Endophytic organisms are known to have varied effects on their host organism in terrestrial and marine environments. (degruyter.com)
  • Host specificity testing of Diorhabda carinulata (Coleoptera: Chrysomelidae) as a biological control agent of Tamarix spp. (wits.ac.za)
  • [8] The white-footed mouse is the favored host for the parasitic botfly Cuterebra fontinella . (wikipedia.org)
  • The high genetic structure of Symbiodinium populations and the association with one particular symbiont lineage across large geographic scales suggests strong regional endemism and the existence of specificity in Aiptasia-Symbiodinium symbioses. (auburn.edu)
  • Later outdoor-caged trials found that the beetles alighted and laid eggs on T. usneoides, indicating the possible inclusion of T. usneoides in the host range of the agent. (wits.ac.za)
  • It is especially important to conduct this work if there was no host range testing prior to release of the agent. (stanford.edu)
  • In order to determined the specificity and population genetic structure of Symbiodinium communities associated with Aiptasia spp. (auburn.edu)
  • Enzyme inhibitors can be divided into reversible inhibitors and irreversible inhibitors, which shows relative specificity or selectivity for enzymes, inhibiting one or several kinds of enzymes[15]. (natural-foundation-science.org)
  • Such preference of T. mitsukurii was also confirmed by the bioassay involving the synthetic chemical cues of the aforementioned host. (unitn.it)