Heterocyclic Compounds: Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)Heterocyclic Compounds, Bridged-Ring: A class of organic compounds which contain two rings that share a pair of bridgehead carbon atoms.Nitrogen Compounds: Inorganic compounds that contain nitrogen as an integral part of the molecule.Cyclization: Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Heterocyclic Compounds, 2-Ring: A class of organic compounds containing two ring structures, one of which is made up of more than one kind of atom, usually carbon plus another atom. The heterocycle may be either aromatic or nonaromatic.Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.Heterocyclic Compounds with 4 or More Rings: A class of organic compounds containing four or more ring structures, one of which is made up of more than one kind of atom, usually carbon plus another atom. The heterocycle may be either aromatic or nonaromatic.Heterocyclic Compounds, 3-Ring: A class of organic compounds containing three ring structures, one of which is made up of more than one kind of atom, usually carbon plus another atom. The heterocycle may be either aromatic or nonaromaticMolecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Heterocyclic Compounds, 1-Ring: A class of organic compounds containing a ring structure made up of more than one kind of atom, usually carbon plus another atom. The ring structure can be aromatic or nonaromatic.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).

*  DESIGN AND SYNTHESIS OF CHIRAL N-HETEROCYCLIC CARBENES WITH APPLICATIONS TO ASYMMETRIC SYNTHESES AND
... SYNTHESIS OF DIBENZAZEPINONES BY PALLADIUM¨CCATALYZED INTRAMOLECULAR ARYLATION OF O- 2¡¯-BROMOPHENYL ANILIDE ENOLATES - D-Scholarship@Pitt. Home. About. FAQ. Help. Login. BROWSE BY:. Year. School. Research Center. Document Type. DESIGN AND SYNTHESIS OF CHIRAL N-HETEROCYCLIC CARBENES WITH APPLICATIONS TO ASYMMETRIC SYNTHESES AND SYNTHESIS OF DIBENZAZEPINONES BY PALLADIUM¨CCATALYZED INTRAMOLECULAR ARYLATION OF O- 2¡¯-BROMOPHENYL ANILIDE ENOLATES. pan, xiaohong 2011 DESIGN AND SYNTHESIS OF CHIRAL N-HETEROCYCLIC CARBENES WITH APPLICATIONS TO ASYMMETRIC SYNTHESES AND SYNTHESIS OF DIBENZAZEPINONES BY PALLADIUM¨CCATALYZED INTRAMOLECULAR ARYLATION OF O- 2¡¯-BROMOPHENYL ANILIDE ENOLATES. Doctoral Dissertation, University of Pittsburgh. Preview. PDF - Primary Text Download 3254Kb. Preview. Abstract Chiral N-heterocyclic carbene NHC ligands were prepared and examined in three asymmetric syntheses oxindole synthesis, pyrrolidine synthesis and cyanosilylation of aldehydes. The ligand generated ...
http://d-scholarship.pitt.edu/7972/
*  π-Face Donation from the aromatic N-substituent of N-Heterocyclic Carbene Ligands to Metal and Its
... Role in Catalysis. BioMedSearch. Document Detail. π-Face Donation from the aromatic N-substituent of N-Heterocyclic Carbene Ligands to Metal and Its Role in Catalysis. MedLine Citation:. PMID: 22524408 Owner: NLM Status: Publisher. In this work we calculate the redox potential in a series of Ir and Ru complexes bearing a N-heterocyclic carbene NHC ligand presenting different Y groups in the para position of the aromatic N-substituent. The calculated redox potentials excellently correlate with the experimental E1/2 potentials, offering a handle to rationalize the experimental findings. Analysis of the HOMO of the complexes before oxidation suggests that electron donating Y groups destabilizes the metal centered HOMO. Energy decomposition of the metal-NHC interaction indicates that electron donating Y groups reinforce this interaction in the oxidized complexes. Analysis of the electron density in the reduced and oxidized states of representative complexes indicates a clear donation from the ...
http://biomedsearch.com/nih/Face-Donation-from-aromatic-N/22524408.html
*  heterocyclic compounds with 4 or more rings
... alertme. You are here: Research Topics chemicals and drugs. heterocyclic compounds heterocyclic compounds with 4 or more rings. Research Topics lactones molecular structure alkaloids stereoisomerism cyclization oxazoles antipsychotic agents structure activity relationship molecular conformation myosin type ii magnetic resonance spectroscopy indoles antineoplastic agents schizophrenia bipolar disorder antitumor drug screening assays medicinal plants benzodiazepines inhibitory concentration 50 x ray crystallography isoquinolines azepines 3 ring heterocyclic compounds quinolines psychiatric status rating scales plant extracts actins tumor cell line piperazines catalysis. Genomes and Genes Sirt1. products. MYH9. products. cdc42. products. Myh9. products. STAT3. products. Ppargc1a. products. Sirt1. products. SIRT3. MMP1. products. Sirt3. products. XIAP. products. Mcl-1. products. TJP1. products. Drd2. products. SIRT1. products. ANLN. products. CDCA8. products. Sirt3. ...
http://labome.org/topics/chemicals/heterocyclic/heterocyclic-compounds-with-4-or-more-rings-11629.html
*  Category:Aromatic nitrogen heterocycles
category aromatic nitrogen heterocycles category aromatic nitrogen heterocycles category nitrogen heterocycles category aromatic compounds
https://en.wikipedia.org/wiki/Category:Aromatic_nitrogen_heterocycles
*  Category:Heterocyclic compounds with 2 rings - Wikimedia Commons
... Open main menu. Category:Heterocyclic compounds with 2 rings. Subcategories. This category has the following 45 subcategories, out of 45 total. A ►. Anethofuran ‎ 2 F. B ►. Benzazocines ‎ 1 C. ►. Benzimidazoles ‎ 19 C, 103 F. ►. Benzisothiazolines ‎ 6 F. ►. Benzisoxazoles ‎ 2 C, 1 F. ►. Benzodiazepines ‎ 27 C, 170 F. ►. Benzodihydropyrans ‎ 1 C, 40 F. ►. Benzodioxoles ‎ 18 C, 181 F. ►. Benzofuran ‎ 13 F. ►. Benzopyranes ‎ 4 C, 31 F. ►. Benzothiadiazoles ‎ 2 F. ►. Benzothiazoles ‎ 4 C, 37 F. ►. Benzothiophenes ‎ 3 C, 38 F. ►. Benzotriazoles ‎ 4 C, 27 F. ►. Benzoxazines ‎ 1 C, 14 F. ►. Benzoxazoles ‎ 3 C, 24 F. ►. Bischler-Napieralski reaction ‎ 1 C, 14 F. C ►. Clavulanic acid ‎ 6 F. ►. Coumarins ‎ 6 C, 108 F. D ►. Decahydroquinolines ‎ 2 F. I ►. Indazole ‎ 13 F. ►. Indazoles ‎ 2 C, 32 F. ►. Indoles ‎ 35 C, 330 F. ►. Indolines ‎ 15 F. ►. Indolizines ‎ 1 C, 3 F. ►. Isoindoles ‎ 2 C, 5 F. ►. Isoindolines ‎ 10 F. ►. Isoquinolines ‎ 7 C, 35 F. L ►. Levamisole ‎ 15 F. N ►. Naphthyridines ‎ 4 C, ...
https://commons.m.wikimedia.org/wiki/Category:Heterocyclic_compounds_with_2_rings
*  Category:Nitrogen heterocycles
category nitrogen heterocycles category nitrogen heterocycles category heterocyclic compounds according to element category organonitrogen compounds
https://en.wikipedia.org/wiki/Category:Nitrogen_heterocycles
*  POE10-03: A Phase I Study of Using Plerixafor as a Chemosensitizing Agent for Relapsed Acute Leukem
... ia and MDS in Pediatric Patients. Clinical Services. Clinical Services. Quick Links Continuing Medical Education. Research At Cincinnati Children's. Our Clinical Services. Cancer - Leukemia and Lymphoma POE10-03: A Phase I Study of Using Plerixafor as a Chemosensitizing Agent for Relapsed Acute Leukemia and MDS in Pediatric Patients. POE10-03: A Phase I Study of Using Plerixafor as a Chemosensitizing Agent for Relapsed Acute Leukemia and MDS in Pediatric Patients What is the purpose of this study. Cytarabine and etoposide have been used as part of standard chemotherapy for ALL and AML. However, the use of plerixafor with cytarabine and etoposide in pediatric patients with relapsed or refractory ALL, AML and MDS is considered experimental. Inclusion Criteria = 3 years of age and 30 years old at study entry diagnosis of relapsed/refractory AML, ALL, secondary AML/MDS, or acute leukemia of ambiguous lineage and meet the following criteria: AML/MDS or leukemia with ambiguous lineage must have 5% blast in ...
http://cincinnatichildrens.org/service/c/clinical-trials/search-studies/leukemia-lymphoma/poe-10-13/
*  Gordon Research Conferences - 1998 Meeting - Heterocyclic Compounds
... Gordon Research Conferences. Conferences. Past Meetings. Contact Chairs. About GRC. Contact Information. News and Events. Home Current Meetings 2016 Past Meetings Gordon Research Seminars Conference Portfolio Proposing a New Gordon Conference Online Application Site, Travel & Poster Information Registration, Payment & Fee Information Guides for Attendees Minority Diversity Initiative Contact Chairs About GRC Governance Contact Information News and Events Supporting GRC Alexander M. Heterocyclic Compounds Gordon Research Conference Dates June 28 - July 3, 1998 Location Salve Regina University Newport, RI Organizers Chair: Paul L. Contact Chairs. Conference History Contact Chairs. What is RSS. About RSS: RSS Really Simple Syndication is a standardized format for publishing news and web content updates. These updates, known as "RSS feeds", can be read using software called an RSS reader or "news aggregator". Subscribing to a feed is a great way to keep up with news and updates for a ...
http://grc.org/programs.aspx?year=1998&program=hetero
*  Cyclam
... {{chembox Verifiedfields = changed Watchedfields = changed verifiedrevid = 460109331 ImageFile= Cyclam.png ImageSize= 120px ImageAlt= ImageFile1 = Cyclam, 2015-10-22.jpg ImageSize1 = ImageAlt1 = Cyclam, recrystallised from chloroform and chlorobenzene twice IUPACName=1,4,8,11-Tetraazacyclotetradecane Section1={{Chembox Identifiers CASNo Ref =. CASNo=295-37-4 ChEMBL Ref = {{ebicite|correct|EBI}} ChEMBL = 125150 PubChem = 64964 ChemSpiderID Ref = {{chemspidercite|correct|chemspider}} ChemSpiderID = 58489 ChEBI Ref = ebicite|correct|EBI ChEBI = 37401 SMILES = N1CCNCCCNCCNCCC1 StdInChI Ref = stdinchicite|correct|chemspider}} StdInChI=1S/C10H24N4/c1-3-11-7-9-13-5-2-6-14-10-8-12-4-1/h11-14H,1-10H2 StdInChIKey Ref = stdinchicite|correct|chemspider StdInChIKey = MDAXKAUIABOHTD-UHFFFAOYSA-N. 'Cyclam' 1,4,8,11-tetraazacyclotetradecane is an organic compound with the formula NHCH 2 CH 2 NHCH 2 CH 2 CH 2 2. The compound is notable as a macrocyclic ligand, which binds strongly to many transition metal cation s. The ...
https://en.wikipedia.org/wiki/Cyclam
*  Filgrastim With or Without Plerixafor in Treating Patients With Multiple Myeloma Previously Treated
... With Lenalidomide - Study Results - ClinicalTrials.gov. National Institutes of Health Example: "Heart attack" AND "Los Angeles" Search for studies:. ClinicalTrials.gov Background. Disclaimer. Find Studies Study Record Detail. Filgrastim With or Without Plerixafor in Treating Patients With Multiple Myeloma Previously Treated With Lenalidomide This study has been terminated. Slow Accrual Sponsor: Case Comprehensive Cancer Center Collaborator: National Cancer Institute NCI Information provided by Responsible Party : Case Comprehensive Cancer Center. ClinicalTrials.gov Identifier: NCT01301963 First received: February 22, 2011 Last updated: July 7, 2014 Last verified: July 2014 History of Changes. Study Results. Disclaimer. Results First Received: July 7, 2014 Study Type: Interventional. Hide Participant Flow. Key information relevant to the recruitment process for the overall study, such as dates of the recruitment period and locations No text entered. Significant events and approaches for the overall study ...
https://clinicaltrials.gov/ct2/show/results/NCT01301963
*  Category:Dioxetanes
category dioxetanes category dioxetanes category oxygen heterocycles category heterocyclic compounds ring
https://en.wikipedia.org/wiki/Category:Dioxetanes
*  Heterocyclic Compounds
... Login. Sign Up. Help. Contact. Home. Search. Search Tutorial. Matches 401 - 450 out of 7,088. 2 3 4 5 6 7 8 9. 10. 11. 12. 13. 14. 15. 16. Document Document Title. WO/2007/069777A2 FUNGICIDAL COMPOSITION CONTAINING CARBOXYLIC ACID AMIDE DERIVATIVE Conventional fungicidal compositions have had practical problems such that either a preventive effect or a curative effect is inadequate, the residual effect tends to be inadequate, or the controlling effect against plant diseases tends ... WO/2007/068330A1 2-ADAMANTYLUREA DERIVATIVES AS SELECTIVE 11β-HSD1 INHIBITORS The present invention relates to 2-adamantylurea derivatives of formula I as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 11β-HSD1 and the use of such compounds for the treatment and prevention of m... WO/2007/063925A1 2-AMINOBENZAMIDE DERIVATIVE Disclosed is a novel and excellent therapeutic or prophylactic agent for nociceptive pain, neuropathic pain, cancer pain, headache, bladder dysfunction or the ...
http://sumobrain.com/ICL-C07D319-p9.html
*  Heterocyclic compound
{{Other uses of|ring structure|Ring structure disambiguation Ring structure}} Image: Pyridine , a heterocyclic compound File:Cyclooctasulfur structural formula 3D.svg|thumb|180px. A '''heterocyclic compound''' or '''ring structure''' is a cyclic compound that has atoms of at least two different elements as members of its ring s. Classification based on electronic structure 3-membered rings 4-membered rings 5-membered rings 6-membered rings 7-membered rings 8-membered rings Images Fused rings History of heterocyclic chemistry Commercial exploitation References External links. Classification based on electronic structure. Heterocyclic compounds can be usefully classified based on their electronic structure. Thus, piperidine and tetrahydrofuran are conventional amines and ethers, with modified steric profiles. Included are pyridine, thiophene, pyrrole, and furan. Another large class of heterocycles are fused to benzene rings, which for pyridine, thiophene, pyrrole, and furan ...
https://en.wikipedia.org/wiki/Heterocyclic_compound
*  Category:Hasubanans
category hasubanans category hasubanans category nitrogen heterocycles category heterocyclic compounds or more rings category heterocyclic compounds bridged ring
https://en.wikipedia.org/wiki/Category:Hasubanans
*  DailyMed - PROHANCE- gadoteridol injection, solution
... Get RSS News Updates. About Dailymed. NLM SPL Resources. DailyMed. Human Drugs. Human Drugs. Get RSS News & Updates. FDA Guidances Information NLM SPL Resources. Get RSS News Updates. NLM SPL Resources. Get RSS News Updates. NLM SPL Resources. ProHance Gadoteridol Injection is a nonionic contrast medium for magnetic resonance imaging MRI, available as a 0.5M sterile clear colorless to slightly yellow aqueous solution in vials and syringes for intravenous injection. The GBCA-associated NSF risk appears highest for patients with chronic, severe kidney disease GFR 30 mL/min/1.73m 2 as well as patients with acute kidney injury. The risk of acute kidney injury may increase with increasing dose of the contrast agent; administer the lowest dose necessary for adequate imaging. Patients with a history of allergy, drug reactions or other hypersensitivity-like disorders should be closely observed during the procedure and for several hours after drug administration. After ProHance is drawn into a syringe, the ...
http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=778aee03-7d4c-481a-be8a-a75db0702f5a
*  Progress in Heterocyclic Chemistry, Volume 8 | 978-0-08-042795-9 | Elsevier
Progress in Heterocyclic Chemistry, Volume 8. 978-0-08-042795-9. Elsevier. Skip to content Feedback Menu. REST MAGIC. Products - Book. Info/Buy View on ScienceDirect. Progress in Heterocyclic Chemistry, Volume 8 A critical review of the 1995 literature preceded by two chapters on current heterocyclic topics Edited by H. Suschitzky, Department of Chemistry and Applied Chemistry, University of Salford, UK G.W. Gribble, Department of Chemistry, Dartmouth College, 6128 Burke Laboratory, Hanover, NH, USA Progress in Heterocyclic Chemistry PHC is an annual review series commissioned by the International Society of Heterocyclic Chemistry ISHC. The volumes in the series contain both highlights of the previous year's literature on heterocyclic chemistry and articles on new developing topics of interest to heterocyclic chemists. The highlight chapters in Volume 8 are all written by leading researchers in their field and these chapters constitute a systematic survey of ...
http://elsevier.com/books/progress-in-heterocyclic-chemistry-volume-8/suschitzky/978-0-08-042795-9
*  Category:Oxazaphosphinans
category oxazaphosphinans category oxazaphosphinans category nitrogen heterocycles category heterocyclic compounds ring category oxygen heterocycles category phosphorus heterocycles category alkylating antineoplastic agents
https://en.wikipedia.org/wiki/Category:Oxazaphosphinans
*  Category:Sulfur heterocycles
category sulfur heterocycles category sulfur heterocycles category heterocyclic compounds according to element category organosulfur compounds
https://en.wikipedia.org/wiki/Category:Sulfur_heterocycles
*  Category:Arsenic heterocycles
category arsenic heterocycles category arsenic heterocycles category organoarsenic compounds category heterocyclic compounds according to element
https://en.wikipedia.org/wiki/Category:Arsenic_heterocycles
*  Category:Bismuth heterocycles
category bismuth heterocycles category bismuth heterocycles category organobismuth compounds category heterocyclic compounds according to element
https://en.wikipedia.org/wiki/Category:Bismuth_heterocycles
*  Category:Boron heterocycles
category boron heterocycles category boron heterocycles category heterocyclic compounds according to element category organoboron compounds
https://en.wikipedia.org/wiki/Category:Boron_heterocycles
*  Category:Phosphorus heterocycles
category phosphorus heterocycles category phosphorus heterocycles category heterocyclic compounds according to element category organophosphorus
https://en.wikipedia.org/wiki/Category:Phosphorus_heterocycles
*  1,4,2-Dithiazole
dithiazole dithiazole chembox watchedfields changed verifiedrevid imagefile dithiazole svg imagesize px iupacname dithiazole othernames section chembox identifiers casno pubchem chemspiderid ref chemspiderid stdinchi ref stdinchicite correct chemspider stdinchi s c h ns c h h h stdinchikey ref stdinchicite correct chemspider stdinchikey mnnjlazjqbwsst uhfffaoysa n smiles c sc ns section chembox properties c h n s appearance density meltingpt boilingpt solubility section chembox hazards mainhazards flashpt autoignitionpt dithiazole is a heterocyclic compound consisting of an unsaturated five membered ring containing two carbon atoms one nitrogen atom and two sulfur atoms category nitrogen heterocycles category sulfur heterocycles
https://en.wikipedia.org/wiki/1,4,2-Dithiazole
*  Category:Thiazolidines
category thiazolidines category thiazolidines category sulfur heterocycles category nitrogen heterocycles category heterocyclic compounds ring
https://en.wikipedia.org/wiki/Category:Thiazolidines
*  Category:Thiazolopyrimidines
category thiazolopyrimidines category thiazolopyrimidines category nitrogen heterocycles category sulfur heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Thiazolopyrimidines
*  Category:Thienobenzodiazepines
category thienobenzodiazepines category thienobenzodiazepines category sulfur heterocycles category nitrogen heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Thienobenzodiazepines
*  Category:Thienothiazines
category thienothiazines category thienothiazines category nitrogen heterocycles category sulfur heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Thienothiazines
*  Category:Dioxoloisoquinolines
category dioxoloisoquinolines category dioxoloisoquinolines category oxygen heterocycles category nitrogen heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Dioxoloisoquinolines
*  Category:Furopyridines
category furopyridines category furopyridines category nitrogen heterocycles category oxygen heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Furopyridines
*  Category:Isoxazolidines
category isoxazolidines category isoxazolidines category nitrogen heterocycles category oxygen heterocycles category heterocyclic compounds ring
https://en.wikipedia.org/wiki/Category:Isoxazolidines
*  Category:Oxadiazolidines
category oxadiazolidines category oxadiazolidines category oxygen heterocycles category nitrogen heterocycles category heterocyclic compounds ring
https://en.wikipedia.org/wiki/Category:Oxadiazolidines
*  Category:Oxazolobenzodiazepines
category oxazolobenzodiazepines category oxazolobenzodiazepines category oxygen heterocycles category nitrogen heterocycles category heterocyclic compounds rings category benzodiazepines
https://en.wikipedia.org/wiki/Category:Oxazolobenzodiazepines
*  Category:Oxazolopyrrolopyrazines
category oxazolopyrrolopyrazines category oxazolopyrrolopyrazines category oxygen heterocycles category nitrogen heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Oxazolopyrrolopyrazines
*  Category:Pyranoindolizinoquinolines
category pyranoindolizinoquinolines category pyranoindolizinoquinolines category oxygen heterocycles category nitrogen heterocycles category heterocyclic compounds or more rings
https://en.wikipedia.org/wiki/Category:Pyranoindolizinoquinolines
*  7-Phenylalkyl Substituted 2-Quinolinones and 2-Quinoxalinones as Poly(Adp-Ribose) Polymerase Inhibit
a n is 0 or 1;b X is N or CR 7, wherein R 7 is hydrogen;c R 1 is C 1 -6alkyl;d R 2 is hydrogen;e R 3 is a radical selected from a-1 or a-2 or is group of formula b-1 ;f s is 0, 1 or 2;g R 8 is C 1 -6alkyl or arylC 1 -6alkyl C 1 -6alkyl aminoC 1 -6alkyl;h t is 0, 1 or 2;i Z is a heterocyclic ring system selected from c-1, c-2, c-3, c-4, c-5 or c-11 ;j each R 12 independently is hydrogen or C 1 -6alkyloxyC 1 -6alkylamino;k each R 13 independently is hydrogen; andl R 4, R 5 and R 6 are each independently selected from hydrogen, halo or C 1 -6alkyl. b X is N; c R 1 is C 1 -6alkyl;d R 2 is hydrogen;e R 3 is a radical of formula a-1 or is a group of formula b-1 ;f s is 0;g R 8 is arylC 1 -6alkyl C 1 -6alkyl aminoC 1 -6alkyl;h t is 0;i Z is a heterocyclic ring system selected from c-1 or c-2 ;j each R 12 independently is hydrogen or C 1 -6alkyloxyC 1 -6alkylamino;k each R 13 independently is hydrogen; andk R 4, R 5 and R 6 are each independently selected from hydrogen or halo. A group of preferred ...
http://faqs.org/patents/app/20080249099
*  Category:Pyridines
category pyridines category pyridines category heterocyclic compounds ring category aromatic nitrogen heterocycles
https://en.wikipedia.org/wiki/Category:Pyridines
*  Category:Indoles
category indoles category indoles category heterocyclic compounds rings category nitrogen heterocycles
https://en.wikipedia.org/wiki/Category:Indoles
*  Category:Azepanes
category azepanes category azepanes category nitrogen heterocycles category heterocyclic compounds ring
https://en.wikipedia.org/wiki/Category:Azepanes
*  Category:Azepines
category azepines category azepines category nitrogen heterocycles category heterocyclic compounds ring
https://en.wikipedia.org/wiki/Category:Azepines
*  Category:Azetidines
category azetidines category azetidines category nitrogen heterocycles category heterocyclic compounds ring
https://en.wikipedia.org/wiki/Category:Azetidines
*  Category:Azocanes
category azocanes category azocanes category nitrogen heterocycles category heterocyclic compounds ring
https://en.wikipedia.org/wiki/Category:Azocanes
*  Category:Benzimidazolines
category benzimidazolines category benzimidazolines category heterocyclic compounds rings category nitrogen heterocycles
https://en.wikipedia.org/wiki/Category:Benzimidazolines
*  Category:Benzocycloheptapyridines
category benzocycloheptapyridines category benzocycloheptapyridines category nitrogen heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Benzocycloheptapyridines
*  Category:Benzoquinolines
category benzoquinolines category benzoquinolines category heterocyclic compounds rings category nitrogen heterocycles
https://en.wikipedia.org/wiki/Category:Benzoquinolines
*  Category:Decahydroisoquinolines
category decahydroisoquinolines category decahydroisoquinolines category nitrogen heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Decahydroisoquinolines
*  Category:Diazepanes
category diazepanes category diazepanes category nitrogen heterocycles category heterocyclic compounds ring
https://en.wikipedia.org/wiki/Category:Diazepanes
*  Category:Dibenzoquinolines
category dibenzoquinolines category dibenzoquinolines category nitrogen heterocycles category heterocyclic compounds or more rings
https://en.wikipedia.org/wiki/Category:Dibenzoquinolines
*  Category:Imidazobenzodiazepines
category imidazobenzodiazepines category imidazobenzodiazepines category nitrogen heterocycles category heterocyclic compounds rings category benzodiazepines
https://en.wikipedia.org/wiki/Category:Imidazobenzodiazepines
*  Category:Indolines
category indolines category indolines category nitrogen heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Indolines
*  Category:Indolomorphinans
category indolomorphinans category indolomorphinans category nitrogen heterocycles category heterocyclic compounds or more rings
https://en.wikipedia.org/wiki/Category:Indolomorphinans
*  Category:Indolonaphthyridines
category indolonaphthyridines category indolonaphthyridines category nitrogen heterocycles category heterocyclic compounds or more rings
https://en.wikipedia.org/wiki/Category:Indolonaphthyridines
*  Category:Indoloquinolizines
category indoloquinolizines category indoloquinolizines category nitrogen heterocycles category heterocyclic compounds or more rings
https://en.wikipedia.org/wiki/Category:Indoloquinolizines
*  Category:Isoindolines
category isoindolines category isoindolines category nitrogen heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Isoindolines
*  Category:Isoquinolinoisoquinolines
category isoquinolinoisoquinolines category isoquinolinoisoquinolines category nitrogen heterocycles category heterocyclic compounds or more rings
https://en.wikipedia.org/wiki/Category:Isoquinolinoisoquinolines
*  Category:Purines
category purines category purines category nitrogen heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Purines
*  Category:Pyrazolidines
category pyrazolidines category pyrazolidines category nitrogen heterocycles category heterocyclic compounds ring
https://en.wikipedia.org/wiki/Category:Pyrazolidines
*  Category:Pyrazolopyridines
category pyrazolopyridines category pyrazolopyridines category nitrogen heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Pyrazolopyridines
*  Category:Pyrazoloquinolines
category pyrazoloquinolines category pyrazoloquinolines category nitrogen heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Pyrazoloquinolines
*  Category:Pyridobenzodiazepines
category pyridobenzodiazepines category pyridobenzodiazepines category nitrogen heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Pyridobenzodiazepines
*  Category:Pyridodiazepenes
category pyridodiazepenes category pyridodiazepenes category nitrogen heterocycles category heterocyclic compounds rings category benzodiazepines
https://en.wikipedia.org/wiki/Category:Pyridodiazepenes
*  Category:Pyridoindoles
category pyridoindoles category pyridoindoles category nitrogen heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Pyridoindoles
*  Category:Pyridoisoquinolines
category pyridoisoquinolines category pyridoisoquinolines category nitrogen heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Pyridoisoquinolines
*  Category:Pyridopyrimidines
category pyridopyrimidines category pyridopyrimidines category nitrogen heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Pyridopyrimidines
*  Category:Pyrimidopyrimidines
category pyrimidopyrimidines category pyrimidopyrimidines category nitrogen heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Pyrimidopyrimidines
*  Category:Pyrrolines
category pyrrolines category pyrrolines category nitrogen heterocycles category heterocyclic compounds ring
https://en.wikipedia.org/wiki/Category:Pyrrolines
*  Category:Pyrrolizidines
category pyrrolizidines category pyrrolizidines category nitrogen heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Pyrrolizidines
*  Category:Pyrrolizines
category pyrrolizines category pyrrolizines category nitrogen heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Pyrrolizines
*  Category:Pyrroloindoles
category pyrroloindoles category pyrroloindoles category heterocyclic compounds rings category nitrogen heterocycles
https://en.wikipedia.org/wiki/Category:Pyrroloindoles
*  Category:Pyrroloisoquinolines
category pyrroloisoquinolines category pyrroloisoquinolines category nitrogen heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Pyrroloisoquinolines
*  Category:Pyrrolopyrazines
category pyrrolopyrazines category pyrrolopyrazines category nitrogen heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Pyrrolopyrazines
*  Category:Pyrrolopyridines
category pyrrolopyridines category pyrrolopyridines category nitrogen heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Pyrrolopyridines
*  Category:Pyrrolopyrimidines
category pyrrolopyrimidines category pyrrolopyrimidines category nitrogen heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Pyrrolopyrimidines
*  Category:Triazolopyridines
category triazolopyridines category triazolopyridines category nitrogen heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Triazolopyridines
*  Category:Triazolopyrimidines
category triazolopyrimidines category triazolopyrimidines category nitrogen heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Triazolopyrimidines
*  Patent US5866557 - Use of an ester of inositoltrisphosphate for the treatment of inflammatory ... -
6 ##STR9## where n is an integer between 1 and 10 and where R 10 is hydrogen or a substituted or unsubstituted, straight or branched alkyl, cycloalkyl, aryl or aralkyl; preferably n is 2 or 3 and R 10 is hydrogen or a lower alkyl such as methyl, ethyl or propyl. 7 ##STR10## where n is an integer between 1 and 10 and where R 9 is a substituted or unsubstituted, straight or branched alkyl, cycloalkyl, aryl or aralkyl; preferably n is 1 and R 9 is a lower alkyl such as methyl, ethyl or propyl. 8 ##STR11## where n is an integer between 1 and 10 and where R 9 is a substituted or unsubstituted, straight or branched alkyl, cycloalkyl, aryl or aralkyl, and where R 10 is hydrogen or substituted or unsubstituted, straight or branched alkyl, cycloalkyl, aryl or aralkyl; preferably n is 1, R 9 is lower alkyl such as methyl, ethyl or propyl and R 10 is hydrogen. 9 ##STR12## where n is an integer between 1 and 10 and where R 9 is a substituted or unsubstituted, straight or branched alkyl, cycloalkyl, aryl or aralkyl and ...
http://google.com/patents/US5866557?dq=ascentive
*  Kuhn, Norbert: Heterocycles as ligands. XII. Synthesis and structure of (C28H40N)MgC2H5.2C4H8O. Stab
kuhn norbert heterocycles as ligands xii synthesis and structure of c h n mgc h c h o stabilization of a monomeric organomagnesium amide by steric crowding inhalt zielgruppeneinstieg hauptnavigation universit t duisburg essen duepublico kuhn norbert heterocycles as ligands xii synthesis and structure of c h n mgc h c h o stabilization of a monomeric organomagnesium amide by steric crowding ub duepublico suchergebnisse eintrag nr semesterapparate videos podcasts lehrmaterial dissertationen e publikationen universit tsbibliographie allgemeines suchen publikation melden weitere informationen korb statistiken suchen mein dokumentenkorb infos f r autoren ber duepublico a z english in den korb xml mods bibtex endnote ris isi word bib kuhn norbert schulten michael boese roland blaeser dieter heterocycles as ligands xii synthesis and structure of c h n mgc h c h o stabilization of a monomeric organomagnesium amide by steric crowding in journal of organometallic chemistry jg nr s issn x zeitschriftenaufsatz fach ...
http://duepublico.uni-duisburg-essen.de/servlets/DozBibEntryServlet?mode=show&id=12115
*  NY I89002 - The tariff classification of 4-Hydroxy-2,2,6,6-Tetramethylpiperidinlyoxy (CAS 2226-96-2)
ny i the tariff classification of hydroxy tetramethylpiperidinlyoxy cas from china united states international trade commision rulings united states international trade commision rulings and harmonized tariff schedule faqs org rulings by number rulings by category tariff numbers faqs org rulings and tariffs home rulings by number ny rulings ny i ny i ny i previous ruling next ruling ny i december cla rr nc i category classification tariff no ms lori a rand p a t products inc canal st bangor maine re the tariff classification of hydroxy tetramethylpiperidinlyoxy cas from china dear ms rand in your letter dated november you requested a tariff classification ruling for hydroxy tetramethylpiperidinlyoxy which you have stated will be used as an intermediate for the synthesis of organic chemicals the applicable subheading will be harmonized tariff schedule of the united states hts which provides for heterocyclic compounds with nitrogen hetero atom s only compounds containing an unfused ...
http://faqs.org/rulings/rulings2002NYI89002.html
*  Kuhn, Norbert: Heterocycles as ligands. VI. The bridging coordination of 1,1'-diazaferrocene in a di
kuhn norbert heterocycles as ligands vi the bridging coordination of diazaferrocene in a dinuclear silver complex an uncommon structure inhalt zielgruppeneinstieg hauptnavigation universit t duisburg essen duepublico kuhn norbert heterocycles as ligands vi the bridging coordination of diazaferrocene in a dinuclear silver complex an uncommon structure ub duepublico suchergebnisse eintrag nr semesterapparate videos podcasts lehrmaterial dissertationen e publikationen universit tsbibliographie allgemeines suchen publikation melden weitere informationen korb statistiken suchen mein dokumentenkorb infos f r autoren ber duepublico a z english in den korb xml mods bibtex endnote ris isi word bib kuhn norbert horn eva maria boese roland blaeser dieter heterocycles as ligands vi the bridging coordination of diazaferrocene in a dinuclear silver complex an uncommon structure in chemische berichte chem ber jg nr s issn zeitschriftenaufsatz fach chemie abstract reaction of octamethyldiazaferrocene tetramethylpyrrole ...
http://duepublico.uni-duisburg-essen.de/servlets/DozBibEntryServlet?mode=show&id=12129
*  The 2011 Import and Export Market for Heterocyclic Compounds with Nitrogen Hetero-Atom(s) Only, Cont
EUR 86 USD 93 GBP 63. EUR 171 USD 186 GBP 127.
http://researchandmarkets.com/reports/1422326/the_2011_import_and_export_market_for
*  Category:Benzoxathioles
category benzoxathioles category benzoxathioles category oxygen heterocycles category sulfur heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Benzoxathioles
*  Category:Oxathiazines
category oxathiazines category oxathiazines category heterocyclic compounds ring category oxygen heterocycles category sulfur heterocycles category azines
https://en.wikipedia.org/wiki/Category:Oxathiazines
*  Category:Oxathiolanes
category oxathiolanes category oxathiolanes category oxygen heterocycles category sulfur heterocycles category heterocyclic compounds ring category thioethers
https://en.wikipedia.org/wiki/Category:Oxathiolanes
*  Haematopodin B
... chembox verifiedrevid imagefile haematopodin b png imagesize imagealt iupacname othernames section section haematopodin b is a chemical compound that is found in the mushroom mycena haematopus it decomposes to haematopodin under the influence of air and light references category alkaloids found in fungi category nitrogen heterocycles category oxygen heterocycles
https://en.wikipedia.org/wiki/Haematopodin_B
*  Category:Morpholines
category morpholines category morpholines category oxygen heterocycles category nitrogen heterocycles category ethers category amines
https://en.wikipedia.org/wiki/Category:Morpholines
*  Thiete
... chembox verifiedrevid imagefile thietene png imagesize iupacname h thiete othernames section chembox identifiers casno pubchem smiles c c cs section chembox properties formula c h s molarmass appearance density meltingpt boilingpt solubility section chembox hazards mainhazards flashpt autoignitionpt thiete is a heterocyclic compound containing an unsaturated four membered ring with three carbon atoms and one sulfur atom it is more commonly encountered not on its own but in anellated derivatives several of which have been synthesized thietes are generally not very stable structure thiete is a valence isomer of the unknown compound thio acrolein ch chch s thiete has been shown to be planar with a c s c angle of degrees thiete dioxides thiete dioxides are sulfone s the parent being c h so they are more stable than thietes themselves thomas c sedergran and donald c dittmer thiete dioxide and chlorothiete dioxide org synth vol substituted thiete dioxides can also be prepared by cycloaddition of ...
https://en.wikipedia.org/wiki/Thiete
*  Category:Benzodioxins
category benzodioxins category benzodioxins category aromatic compounds category oxygen heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Benzodioxins
*  Thiane
... chembox verifiedfields changed watchedfields changed verifiedrevid imagefilel tetrahydrothiopyran png imagesizel imagealtl skeletal formula of thiane imagefiler thiane d ball png imagesizer imagealtr ball and stick model of the thiane molecule iupacname thiane othernames tetrahydro h thiopyran section chembox identifiers casno ref casno pubchem smiles c ccscc chemspiderid ref chemspidercite changed chemspider chemspiderid inchi c h s c h h inchikey ypwfisctzqnzau uhfffaoyav stdinchi ref stdinchicite changed chemspider stdinchi s c h s c h h stdinchikey ref stdinchicite changed chemspider stdinchikey ypwfisctzqnzau uhfffaoysa n section chembox properties formula c h s molarmass appearance density meltingpt boilingpt solubility section chembox hazards mainhazards flashpt autoignitionpt thiane is a heterocyclic compound containing a saturated six membered ring with five carbon atoms and one sulfur atom category sulfur heterocycles
https://en.wikipedia.org/wiki/Thiane
*  Thietane
... chembox verifiedfields changed watchedfields changed verifiedrevid imagefilel thietan png imagefilel ref imagesizel imagealtl structural formula of thietane imagefiler thietane d ball png imagesizer imagealtr ball and stick model of the thietane molecule iupacname thietane othernames thiacyclobutane trimethylene sulfide section rphrases thietane is a heterocyclic compound containing a saturated four membered ring with three carbon atoms and one sulfur atom references category sulfur heterocycles
https://en.wikipedia.org/wiki/Thietane
*  Thiopyran
... chembox verifiedfields changed watchedfields changed verifiedrevid imagefilel thiapyran svg imagealtl skeletal formula of h thiopyran imagecaptionl h thiopyran imagefiler thiapyran svg imagealtr skeletal formula of h thiopyran imagecaptionr h thiopyran imagefilel thiapyran d ball png imagesizel imagealtl ball and stick model of the thiapyran molecule imagefiler thiapyran d ball png imagesizer imagealtr ball and stick model of the thiapyran molecule iupacname h thiopyran h thiopyran othernames section chembox identifiers casno ref casno chemspiderid ref chemspidercite changed chemspider chemspiderid chemspiderid comment h chemspiderid ref chemspidercite changed chemspider chemspiderid chemspiderid comment h pubchem pubchem comment h pubchem pubchem comment h smiles section chembox properties c h s appearance density meltingpt boilingpt solubility section chembox hazards mainhazards flashpt autoignitionpt thiopyran is a heterocyclic compound with the chemical formula c h s there are two isomers h ...
https://en.wikipedia.org/wiki/Thiopyran
*  Category:Trioxanes
category trioxanes category trioxanes category oxygen heterocycles category heterocyclic compounds ring category ethers
https://en.wikipedia.org/wiki/Category:Trioxanes
*  Category:Benzocycloheptathiophenes
category benzocycloheptathiophenes category benzocycloheptathiophenes category sulfur heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Benzocycloheptathiophenes
*  Category:Benzoisothiazoles
category benzoisothiazoles category benzoisothiazoles category heterocyclic compounds rings category sulfur heterocycles category azoles
https://en.wikipedia.org/wiki/Category:Benzoisothiazoles
*  Category:Benzothiadiazoles
category benzothiadiazoles category benzothiadiazoles category azoles category sulfur heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Benzothiadiazoles
*  Category:Benzothiazines
category benzothiazines category benzothiazines category sulfur heterocycles category azines category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Benzothiazines
*  Category:Dibenzothiepines
category dibenzothiepines category dibenzothiepines category sulfur heterocycles category heterocyclic compounds rings
https://en.wikipedia.org/wiki/Category:Dibenzothiepines
*  Category:Dithietanes
category dithietanes category dithietanes category sulfur heterocycles category heterocyclic compounds ring
https://en.wikipedia.org/wiki/Category:Dithietanes
*  Category:Dithiolanes
category dithiolanes category dithiolanes category sulfur heterocycles category heterocyclic compounds ring
https://en.wikipedia.org/wiki/Category:Dithiolanes
*  Category:Dithioles
category dithioles category dithioles category sulfur heterocycles category heterocyclic compounds ring
https://en.wikipedia.org/wiki/Category:Dithioles
*  Category:Thiepines
category thiepines category thiepines category sulfur heterocycles category heterocyclic compounds ring
https://en.wikipedia.org/wiki/Category:Thiepines
*  Category:Thiiranes
category thiiranes category thiiranes category sulfur heterocycles category heterocyclic compounds ring category thioethers
https://en.wikipedia.org/wiki/Category:Thiiranes

Heterocyclic amine: Heterocyclic amines, also sometime referred to as HCAs, are chemical compounds containing at least one heterocyclic ring, which by definition has atoms of at least two different elements, as well as at least one amine (nitrogen-containing) group. Typically it is a nitrogen atom of an amine group that also makes the ring heterocyclic (e.Ecuadorian cuisine: Ecuadorian cuisine is diverse, varying with altitude, and associated agricultural conditions. Pork, chicken, beef, and (guinea pig) are popular in the mountainous regions, and are served with a variety of carbohydrate-rich foods, especially rice, corn, and potatoes.Nitrogen trichlorideStilbene photocyclization: Stilbene photocyclization is the coupling of two aromatic carbons in stilbenes upon ultraviolet irradiation. The reaction can be used to form polycyclic aromatic hydrocarbons and heteroaromatics.Basic aromatic ring: Basic aromatic rings are aromatic rings in which the lone pair of electrons of a ring-nitrogen atom is not part of the aromatic system and extends in the plane of the ring. This lone pair is responsible for the basicity of these nitrogenous bases, similar to the nitrogen atom in amines.Palladium(II) chlorideRoquefortine CDolutegravirAffibody molecule: Affibody molecules are small proteins engineered to bind to a large number of target proteins or peptides with high affinity, imitating monoclonal antibodies, and are therefore a member of the family of antibody mimetics. Affibody molecules are used in biochemical research and are being developed as potential new biopharmaceutical drugs.Spin–lattice relaxation in the rotating frame: Spin–lattice relaxation in the rotating frame is the mechanism by which Mxy, the transverse component of the magnetization vector, exponentially decays towards its equilibrium value of zero, under the influence of a radio frequency (RF) field in nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI). It is characterized by the spin–lattice relaxation time constant in the rotating frame, T1ρ.

(1/1106) Comparison of ultrasmall particles of iron oxide (USPIO)-enhanced T2-weighted, conventional T2-weighted, and gadolinium-enhanced T1-weighted MR images in rats with experimental autoimmune encephalomyelitis.

BACKGROUND AND PURPOSE: Ultrasmall particles of iron oxide (USPIO) constitute a contrast agent that accumulates in cells from the mononuclear phagocytic system. In the CNS they may accumulate in phagocytic cells such as macrophages. The goal of this study was to compare USPIO-enhanced MR images with conventional T2-weighted images and gadolinium-enhanced T1-weighted images in a model of experimental autoimmune encephalomyelitis (EAE). METHODS: Nine rats with EAE and four control rats were imaged at 4.7 T and 1.5 T with conventional T1- and T2-weighted sequences, gadolinium-enhanced T1-weighted sequences, and T2-weighted sequences obtained 24 hours after intravenous injection of a USPIO contrast agent, AMI-227. Histologic examination was performed with hematoxylin-eosin stain, Perls' stain for iron, and ED1 immunohistochemistry for macrophages. RESULTS: USPIO-enhanced images showed a high sensitivity (8/9) for detecting EAE lesions, whereas poor sensitivity was obtained with T2-weighted images (1/9) and gadolinium-enhanced T1-weighted images (0/9). All the MR findings in the control rats were negative. Histologic examination revealed the presence of macrophages at the site where abnormalities were seen on USPIO-enhanced images. CONCLUSION: The high sensitivity of USPIO for macrophage activity relative to other imaging techniques is explained by the histologic findings of numerous perivascular cell infiltrates, including macrophages, in EAE. This work supports the possibility of intracellular USPIO transport to the CNS by monocytes/macrophages, which may have future implications for imaging of human inflammatory diseases.  (+info)

(2/1106) 67Cu-versus 131I-labeled Lym-1 antibody: comparative pharmacokinetics and dosimetry in patients with non-Hodgkin's lymphoma.

Antilymphoma mouse monoclonal antibody (MoAb) Lym-1, labeled with 67Cu or 131I, has demonstrated promising results in radioimmunotherapy (RIT) for lymphoma. Although 131I has played a central role in RIT thus far, some properties of 67Cu are preferable. A subset of our patients received both 67Cu- and 131I-labeled Lym-1, allowing a comparative evaluation of the two radiopharmaceuticals administered to a matched population of patients. Four patients with B-lymphocytic non-Hodgkin's lymphoma that had progressed despite standard therapy entered trials of 67Cu- and 131I-labeled Lym-1, which were injected 3-26 days apart. Lym-1 was conjugated to 6-[p-(bromoacetamido)benzyl]-1,4,7,11-tetraazacyclotetradecane-N,N ',N",N'"-tetraacetic acid (BAT) via 2-iminothiolane (2IT) and radiolabeled with 67Cu to prepare 67Cu-2IT-BAT-Lym-1; 131I-Lym-1 was preparred by the chloramine-T reaction. Planar imaging was used to quantitate 67Cu-2IT-BAT-Lym-1 or 131I-Lym-1 in organs and tumors daily for 3 days or longer. 67Cu-2IT-BAT-Lym-1 exhibited higher peak concentration in 92% (12 of 13) of tumors and a longer biological half-time in every tumor than 131I-Lym-1. The mean tumor concentration (%ID/g) of 67Cu-2IT-BAT-Lym-1 was 1.7, 2.2, and 2.8 times that of 131I-Lym-1 at 0, 24, and 48 h after injection, respectively. The mean biological half-times of 67Cu-2IT-BAT-Lym-1 and 131I-Lym-1 in tumor were 8.8 and 2.3 days, respectively. Consequently, the mean tumor radiation dose delivered by 67Cu-2IT-BAT-Lym-1 was twice that of 131I-Lym-1, 2.8 (range 0.8-6.7), and 1.4 (range 0.4-35) Gy/GBq, respectively. 67Cu-2IT-BAT-Lym-1 delivered a lower marrow radiation dose than 131I-Lym-1; hence, the tumor:marrow therapeutic indices were 29 and 9.7, respectively. Radiation doses from 67Cu-2IT-BAT-Lym-1 and 131I-Lym-1 to normal tissues were similar except for liver, which received a higher dose from 67Cu-2IT-BAT-Lym-1. Images obtained with 67Cu-2IT-BAT-Lym-1 were superior. Radiation dosimetry data for 67Cu-2IT-BAT-Lym-1 and 131I-Lym-1 agreed with corresponding data from the larger populations of patients from which the matched population for the current study was drawn. In conclusion, 67Cu-2IT-BAT-Lym-1 given to non-Hodgkin's lymphoma patients in close temporal proximity to 131I-Lym-1 exhibited greater uptake and longer retention in tumor, resulting in higher radiation dose and therapeutic index than 131I-Lym-1. These as well as other factors suggest that 67Cu-2IT-BAT-Lym-1 may be superior to 131I-Lym-1 for RIT.  (+info)

(3/1106) Efficacy of RD3-0028 aerosol treatment against respiratory syncytial virus infection in immunosuppressed mice.

RD3-0028, a benzodithiin compound, has antiviral activity against respiratory syncytial virus (RSV) in cell culture. We used a mouse model of RSV infection to determine the in vivo effect of RD3-0028. Cyclophosphamide (CYP)-treated, immunosuppressed mice were inoculated intranasally. The lungs of the mice were removed on day 4. The virus titers of the lungs of RD3-0028-treated mice were compared to the virus titers of the lungs of virus-inoculated, untreated control mice. In an effort to increase the therapeutic effectiveness of this compound, RD3-0028 was administered by aerosol to RSV-infected mice by using a head-exposure system. Aerosols generated from reservoirs containing RD3-0028 (7 mg/ml) administered for 2 h twice daily for 3 days significantly reduced the pulmonary titer of RSV-infected mice. It is clear that the minimal effective dose of RD3-0028 for RSV-infected mice is significantly less than that of ribavirin, the only compound currently available for use against RSV disease. Furthermore, the RD3-0028 aerosol administration appeared to protect the lungs of infected, CYP-treated mice against tissue damage, as evidenced by the preservation of the lung architecture and a reduction in pulmonary inflammatory infiltrates. RD3-0028 aerosol was not toxic for mice at the therapeutic dose. The present study demonstrates the effectiveness of aerosol administration of RD3-0028 for RSV-infected mice.  (+info)

(4/1106) Cancer chemopreventive mechanisms of tea against heterocyclic amine mutagens from cooked meat.

Cooking meat and fish under normal conditions produces heterocyclic amine mutagens, several of which have been shown to induce colon tumors in experimental animals. In our search for natural dietary components that might protect against these mutagens, it was found that green tea and black tea inhibit the formation of heterocyclic amine-induced colonic aberrant crypt foci (ACF) in the rat. Since ACF are considered to be putative preneoplastic lesions, we examined the inhibitory mechanisms of tea against the heterocyclic amines. In the initial studies using the Salmonella mutagenicity assay, green tea and black tea inhibited according to the concentration of tea leaves during brewing and the time of brewing; a 2-3-min brew of 5% green tea (w/v) was sufficient for >90% antimutagenic activity. N-hydroxylated heterocyclic amines, which are direct-acting mutagens in Salmonella, were inhibited by complete tea beverage and by individual components of tea, such as epigallocatechin-3-gallate (EGCG). Inhibition did not involve enhanced mutagen degradation, and EGCG and other catechins complexed only weakly with the mutagens, suggesting electrophile scavenging as an alternative mechanism. Enzymes that contribute to the metabolic activation of heterocyclic amines, namely microsomal NADPH-cytochrome P450 reductase and N, O-acetyltransferase, were inhibited by tea in vitro. Studies in vivo established that tea also induces cytochromes P450 and Phase II enzymes in a manner consistent with the rapid metabolism and excretion of heterocyclic amines. Collectively, the results indicate that tea possesses anticarcinogenic activity in the colon, and this most likely involves multiple inhibitory mechanisms.  (+info)

(5/1106) The Saccharomyces cerevisiae hyperrecombination mutant hpr1Delta is synthetically lethal with two conditional alleles of the acetyl coenzyme A carboxylase gene and causes a defect in nuclear export of polyadenylated RNA.

In a screen for mutants that display synthetic lethal interaction with hpr1Delta, a hyperrecombination mutant of Saccharomyces cerevisiae, we have isolated a novel cold-sensitive allele of the acetyl coenzyme A (CoA) carboxylase gene, acc1(cs), encoding the rate-limiting enzyme of fatty acid synthesis. The synthetic lethal phenotype of the acc1(cs) hpr1Delta double mutant was only partially complemented by exogenous fatty acids. hpr1Delta was also synthetically lethal with a previously isolated, temperature-sensitive allele of ACC1, mtr7 (mRNA transport), indicating that the lethality of the acc1(cs) hpr1Delta double mutant was not allele specific. The basis for the interaction between conditional acc1 alleles and hpr1Delta was investigated in more detail. In the hpr1Delta mutant background, acetyl-CoA carboxylase enzyme activity was reduced about 15-fold and steady-state levels of biotinylated Acc1p and ACC1 mRNA were reduced 2-fold. The reduced Acc1p activity in hpr1Delta cells, however, did not result in an altered lipid or fatty acid composition of the mutant membranes but rendered cells hypersensitive to soraphen A, an inhibitor of Acc1p. Similar to mtr7, hpr1Delta and acc1(cs) mutant cells displayed a defect in nuclear export of polyadenylated RNA. Oversized transcripts were detected in hpr1Delta, and rRNA processing was disturbed, but pre-mRNA splicing appeared wild type. Surprisingly, the transport defect of hpr1Delta and acc1(cs) mutant cells was accompanied by an altered ring-shaped structure of the nucleolus. These observations suggest that the basis for the synthetic lethal interaction between hpr1Delta and acc1 may lie in a functional overlap of the two mutations in nuclear poly(A)+ RNA production and export that results in an altered structure of the nucleolus.  (+info)

(6/1106) Diverse oxygenations catalyzed by carbazole 1,9a-dioxygenase from Pseudomonas sp. Strain CA10.

Carbazole 1,9a-dioxygenase (CARDO) from Pseudomonas sp. strain CA10 is a multicomponent enzyme that catalyzes the angular dioxygenation of carbazole, dibenzofuran, and dibenzo-p-dioxin. It was revealed by gas chromatography-mass spectrometry and 1H and 13C nuclear magnetic resonance analyses that xanthene and phenoxathiin were converted to 2,2',3-trihydroxydiphenylmethane and 2,2',3-trihydroxydiphenyl sulfide, respectively. Thus, for xanthene and phenoxathiin, angular dioxygenation by CARDO occurred at the angular position adjacent to the oxygen atom to yield hetero ring-cleaved compounds. In addition to the angular dioxygenation, CARDO catalyzed the cis dihydroxylation of polycyclic aromatic hydrocarbons and biphenyl. Naphthalene and biphenyl were converted by CARDO to cis-1, 2-dihydroxy-1,2-dihydronaphthalene and cis-2,3-dihydroxy-2, 3-dihydrobiphenyl, respectively. On the other hand, CARDO also catalyzed the monooxygenation of sulfur heteroatoms in dibenzothiophene and of the benzylic methylenic group in fluorene to yield dibenzothiophene-5-oxide and 9-hydroxyfluorene, respectively. These results indicate that CARDO has a broad substrate range and can catalyze diverse oxygenation: angular dioxygenation, cis dihydroxylation, and monooxygenation. The diverse oxygenation catalyzed by CARDO for several aromatic compounds might reflect the differences in the binding of the substrates to the reaction center of CARDO.  (+info)

(7/1106) Pharmacokinetics and pharmacodynamics of Ro 44-3888 after single ascending oral doses of sibrafiban, an oral platelet aggregation inhibitor, in healthy male volunteers.

AIMS: This study constituted the first administration of the oral platelet inhibitor, sibrafiban, to humans. The aim was to investigate the pharmacokinetics and pharmacodynamics of Ro 44-3888, the active principle of sibrafiban, after single ascending oral doses of sibrafiban. Particular emphasis was placed on intersubject variability of the pharmacokinetic and pharmacodynamic parameters of Ro 44-3888. METHODS: The study consisted of three parts. Part I was an open ascending-dose study to determine target effect ranges of sibrafiban. Part II, a double-blind, placebo-controlled, parallel-group study, addressed the intersubject variability of pharmacokinetic and pharmacodynamic parameters of the active principle at a sibrafiban dose achieving an intermediate effect. Part III was a double-blind, placebo-controlled, ascending-dose design covering the complete plasma concentration vs pharmacodynamic response curve of sibrafiban. RESULTS: At sibrafiban doses between 5 mg and 12 mg, the pharmacokinetics of free Ro 44-3888 in plasma were linear whereas those of total Ro 44-3888 were non-linear because of the saturable binding to the glycoprotein IIb-IIIa receptor. Saturation of the GP IIb-IIIa receptor was reached at plasma concentrations of 15.9 ng ml-1. At sibrafiban doses up to 2 mg, ADP-induced platelet aggregation was inhibited by 50%, whereas the inhibition of TRAP-induced platelet aggregation was about 20-30%. At the higher doses, ADP-induced platelet aggregation was almost completely inhibited while a clear dose-response could be observed with TRAP-induced inhibition of platelet aggregation at sibrafiban doses of 5 to 12 mg. Ivy bleeding time increased very steeply with dose with a significant prolongation observed at doses of 5 to 7 mg of sibrafiban (5-7 min, >30 min in one case). At a sibrafiban dose of 12 mg, the stopping criterion for dose escalation (prolongation of the Ivy bleeding time >30 min in three out of four subjects per dose group) was reached. The interindividual coefficients of variation of the integrated pharmacokinetic and pharmacodynamic parameters (AUC and AUE) were below 20%, thus lying well within the pre-set level of acceptance. CONCLUSIONS: With a low intersubject variability of its pharmacokinetic and pharmacodynamic parameters, linear pharmacokinetics and pharmacodynamic effects closely related to its plasma concentrations, Ro 44-3888 has good pharmacological prerequisites for a well controllable therapy of secondary prevention of arterial thrombosis in patients with acute coronary syndrome.  (+info)

(8/1106) Shift of clinical human immunodeficiency virus type 1 isolates from X4 to R5 and prevention of emergence of the syncytium-inducing phenotype by blockade of CXCR4.

The emergence of X4 human immunodeficiency virus type 1 (HIV-1) strains in HIV-1-infected individuals has been associated with CD4(+) T-cell depletion, HIV-mediated CD8(+) cell apoptosis, and an impaired humoral response. The bicyclam AMD3100, a selective antagonist of CXCR4, selected for the outgrowth of R5 virus after cultivation of mixtures of the laboratory-adapted R5 (BaL) and X4 (NL4-3) HIV strains in the presence of the compound. The addition of AMD3100 to peripheral blood mononuclear cells infected with X4 or R5X4 clinical HIV isolates displaying the syncytium-inducing phenotype resulted in a complete suppression of X4 variants and a concomitant genotypic change in the V2 and V3 loops of the envelope gp120 glycoprotein. The recovered viruses corresponded genotypically and phenotypically to R5 variants in that they could no longer use CXCR4 as coreceptor or induce syncytium formation in MT-2 cells. Furthermore, the phenotype and genotype of a cloned R5 HIV-1 virus converted to those of the R5X4 virus after prolonged culture in lymphoid cells. However, these changes did not occur when the infected cells were cultured in the presence of AMD3100, despite low levels of virus replication. Our findings indicate that selective blockade of the CXCR4 receptor prevents the switch from the less pathogenic R5 HIV to the more pathogenic X4 HIV strains, a process that heralds the onset of AIDS. In this article, we show that it could be possible to redirect the evolution of HIV so as to impede the emergence of X4 strains or to change the phenotype of already-existing X4 isolates to R5.  (+info)


nitrogen containing heterocycli


  • This technology is a [4+3] cycloaddition reaction having an intermediate aza-oxyallylcation which can react with an appropriate second reactant to synthesize 7-membered nitrogen containing heterocyclic compounds. (testtechnologypublisher.com)
  • It is involved in the oxidation of nitrogen-containing heterocyclic compounds to lactams, as well as oxidation of aldehydes (as the name implies) and reduction reactions of N-O and N-S bonds. (aspetjournals.org)


biologically


  • Heterocyclic compounds represent an important class of biologically active molecules. (logoburg.com)


amines


  • Research published in the Journal of Food Science suggests that marinating meats may decrease the cancer-forming compounds called heterocyclic amines (HCA), which are produced during grilling, by a whopping 70 percent or more. (blogspot.com)
  • The protein in meat, poultry, and fish create heterocyclic amines (HCAs). (concordfoodcoop.coop)


anticancer


  • Koca İ, Gümüş M, Ö zgür A, Dişli A, Tutar Y. A novel approach to inhibit heat shock response as anticancer strategy by coumarine compounds containing thiazole skeleton. (jacobspublishers.com)


Hsp90


  • Especially, pyrimidine derivative compounds inhibit Heat Shock Protein 90 (Hsp90) chaperone activity, and interrupt proliferation in cancer cell. (jacobspublishers.com)
  • Thermodynamic values of the interaction between the compounds and Hsp90 are determined by molecular docking studies. (jacobspublishers.com)


scaffold


  • These compounds can then be used as a novel scaffold in drug development. (testtechnologypublisher.com)
  • Pyrimidine scaffold is an important member of bioactive heterocyclic compounds which are also used in the treatment of cancer, infection diseases, diabetes, gastrointestinal diseases, and cardiovascular diseases. (jacobspublishers.com)


active


  • This reminded me: A few years back some ±23 patent applications were submitted for furfural-based active compounds for anti retro viral drugs. (dalinyebo.com)
  • The second aim of this project is to develop and synthesise a range of MGBs which will link the head group and/or heterocyclic monomers via an alkene linker, replacing the typical amide links, this should give these compounds enhanced Lipophilicity and in turn better membrane permeability which we hope will result in more active antibacterial compounds. (bl.uk)
  • AstraZeneca has filed a patent infringement complaint in the US District Court for the District of New Jersey against Novartis generic unit - Sandoz alleging infringement of the US 4,879,288 (the '288 patent) protecting Quetiapine fumarate, the active ingredient of SEROQUEL , and methods of using that compound. (blogspot.com)


peptide


  • Additionally, different bis-N-heterocyclic carbene (NHC) gold(I) complexes based on the amino acid L-histidine are prepared for the integration into the structure of the peptide through exchange of one amino acid. (tum.de)


molecular


  • this may allow these compounds to have a range of further application other than as antibacterial agents, as potential analytical tool for example as molecular stains etc. (bl.uk)
  • Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focusing on small chemical compounds. (isciencesearch.com)


pharmaceuticals


  • Nitrogen based heterocyclic compounds are widely represented in natural products, pharmaceuticals, peptidomimetics, and monomers for polymerization. (testtechnologypublisher.com)


biological activity


  • The reaction will produce nitrogen-based seven membered heterocycles (also referred to as azepanes) which have been proven as both intermediates and compounds that exhibit useful biological activity. (testtechnologypublisher.com)


amino


  • Additionally, different bis-N-heterocyclic carbene (NHC) gold(I) complexes based on the amino acid L-histidine are prepared for the in. (tum.de)


class


  • Indolo[3,2- c ]quinolines are pharmacologically attractive class of heterocyclic compounds. (dalinyebo.com)
  • Distamycin 1 and netropsin 2 are naturally occurring MOBs, and are members of the polypyrrole class of compounds. (bl.uk)
  • Prodigiosin a bacterial secondary metabolite is a heterocyclic compound belongs to the class of tripyrrole, synthesized by various strains of bacteria includes Serratia species. (jams.org.au)


targets


  • This intermediate is a suitable compound which allows for several direct synthesization targets in carbocyclic nucleosides and their analogs, polyhydroxylated alkaloids, and polyhydroxylated azepanes. (testtechnologypublisher.com)


Preparation


  • Chennai Patent Office has issued an Indian Patent Number 203560 titled New heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them. (blogspot.com)


useful


  • More useful routes to heterocyclic compounds! (rsc.org)


research


  • In early drug research efforts, it is commonplace for newly synthesized compounds to be tested for proclivity to high clearance by incubating with human liver microsomes and cofactors to support cytochrome P450 activity ( Obach, 2001 ). (aspetjournals.org)


systems


  • These compounds were assayed using two in vitro systems (pooled human liver cytosol and liver S -9 fractions) to calculate scaled unbound intrinsic clearance, and they were then compared with calculated in vivo unbound intrinsic clearance. (aspetjournals.org)


activity


  • The compounds exemplified in the '367 patent disclosures exhibits antagonistic activity at CRF1 receptors. (blogspot.com)


drug


  • The compounds listed below have the potential to or have been used as an intermediate in drug systhesis. (testtechnologypublisher.com)


potential


  • Aldehyde oxidase is a cytosolic enzyme, and thus its potential contribution to the metabolic clearance of new compounds is not addressed in standard metabolic lability screens using liver microsomes. (aspetjournals.org)
  • Among the heterocyclic compounds, Coumarin and coumarin-related compounds have proved to have significant therapeutic potential. (logoburg.com)


high


  • Compounds demonstrating high lability are either discarded or structurally modified to impart improved metabolic stability. (aspetjournals.org)


Especially


  • A freely available collection of data about small molecules (over 2000 compounds) and resources for studying their properties, especially their effects on biology. (isciencesearch.com)


human


  • Although an ability to predict in vivo clearance from in vitro intrinsic clearance (CL int ) data measured in human liver microsomes is well established for P450-cleared compounds, an ability to do the same for aldehyde oxidase-cleared compounds has not been demonstrated. (aspetjournals.org)


several


  • Therefore, several ruthenium(II) polypyridyl complexes are synthesized and selected compounds attached to the cyclic pentapeptide cyc(RGDfK). (tum.de)


What are the primary compounds in beer?


  • What are the primary compounds in beer? Both organic and inorganic is most helpful for my study. This is my third site posting for this and my other question. Thank you Thank you for your effort. Barley is an ingredient but I am looking for the chemicals that constitute a beer/beer flavor. Thanks I would not have considered water or acids.
  • Probably far too many to list. But a short list and extended from the above follows: Alcohol -ethanol -isoamyl alcohol -isomaltose lanosterol -phenol alcohol Aldehydes -isobutyraldehyde -isovaleraldehyde Organic Acids (inorganic) iiso butyric acid isocitric acid -isohexenoic acid -isovaleric acid iso-alpha-acids lactic acid -linoleic acid Esters -Ethyl acetate Isoamyl acetate -Ethyl hexanoate Ketones -isoamyl acetate -lupulone Phenols -phenol alanine -phenol alcohol Sulfer Compounds -epi sulfides


What is the difference between compound and isolated weight lifting?


  • I know that compound works more than one muscle and isolation works only one. But do they do something else? Will isolation make the muscles look more defined?
  • hellz yes. if you isolate each muscle group and do more reps than compound lifting than they will grow faster.


What are some examples of compound exercises?


  • I heard compound exercises are the best for muscle growth. The only one i know of right now is pullups. What are some other ones?


What are the other compounds found in psiloscybe mushrooms?


  • I ask because I had discovered that the compound CBD found in Cannabis is useful in treating psychosis, as well I have found another compound found in Yohimbe that looks like it would be useful in treating psychosis, this makes me believe that there could possibly be other compounds found in psychedelic drugs that may be useful in for treating psychosis if separate from the compound that is abused.
  • Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) Psilocin (4-hydroxy-N,N-dimethyltryptamine) Baeocystin (4-phosphoryloxy-N-methyltryptamine) Norbaeocystin (4-phosphoryloxytryptamine)


Is Rainbow Henna a compound henna? How long do I have to wait to dye my hair with regular permanent color?


  • Is Rainbow Henna a compound henna? How long do I have to wait to dye my hair with regular permanent color once i've already dyed my hair with the Rainbow Henna? Thank you soo much!!
  • I cannot honestly say that I believe Rainbow henna is pure henna, or even pure plant mixes. They have henna kits that list nothing but natural ingredients, but that doesn't mean that's a complete list. They used to sell compound henna, and they currently sell a cream dye that's called henna but contains no henna at all. Some websites mention it contains "colorless" henna, which means it has cassia, another plant which isn't henna and doesn't dye hair unless you're blond. Cassia adds shine, but it's not henna. Personally, I would consider it not real henna, since it says it only lasts 4-6 weeks. Henna is permanent. Rainbow sounds like a temporary dye, possibly one that contains henna extracts or other plants, but not true and pure henna powder. Take some hair from your hair brush and make two balls. Add peroxide to one ball and ammonia to another. If there's no weird reaction after a few hours, then most likely it doesn't contain metallic salts. Although it still may have other unpleasant ingredients. If there is a strange reaction, don't dye your hair with chemical dyes until the henna has grown out and been cut off.


What other chemicals/compounds are similar to bleach?


  • I want to know if there are other chemicals or compounds out there that has same destructive nature (ie ruining clothing) as bleach or chlorine.
  • Water containing excessive amounts of iron and manganese can stain clothes. Are you going for the torn and dirty look or do you just want to play with chemicals? I once mixed boric acid with comet and it ruined my clothes, burned my nostrils, and ran us out of the house for a day. This mixture started to smoke. (I really would suggest this)


Is a skillet a simple or compound machine?


  • I'm doing a physical science project and I am wondering if this is a simple or compound machine. If it is a compound machine, what type of simple machines are contained in it?
  • Depending on what you are cooking it can be either simple or compound. If you are using it to saute, which involves moving the pan in a fashion to make the food jump, then catching it in the pan. Then you are using the skillet handle as a lever and your wrist, is sort of acting as a fulcrum. Furthermore, if you are cooking something with liquid in it, you can tilt the pan toward you while it is on top of the heat source, and gravity will cause all the liquid will gather at the bottom of the pan close to the handle. The heat will cause the liquid to evaporate, and you will have a reduced liquid after a time without burning the food in the rest of the pan. Doing this with the skillet, makes it an inclined plane. So if you really want to be specific, it can be a compound machine or it can be a simple machine... Depending on what you are cooking.


How do you treat a compound fracture when you can't afford medical bills?


  • My boyfriend (Brad) was skiing and he got a compound fracture in his arm. How can we care for it if we can't afford medical bills? How do we take care of it at home?
  • You cannot fix something like this at home. You have no way of knowing if he has done damage within his arm that you cannot see. Take him to the doctor. Most physicians will go easy on you as far as billing goes if you explain that you don't have insurance (or have crappy insurance). Their billing departments will set you up on a payment plan so that you can pay off the balance in installments.