A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)
Gases or volatile liquids that vary in the rate at which they induce anesthesia; potency; the degree of circulation, respiratory, or neuromuscular depression they produce; and analgesic effects. Inhalation anesthetics have advantages over intravenous agents in that the depth of anesthesia can be changed rapidly by altering the inhaled concentration. Because of their rapid elimination, any postoperative respiratory depression is of relatively short duration. (From AMA Drug Evaluations Annual, 1994, p173)
Anesthesia caused by the breathing of anesthetic gases or vapors or by insufflating anesthetic gases or vapors into the respiratory tract.
A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
An extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate.
A group of compounds that contain the general formula R-OCH3.
Agents that are capable of inducing a total or partial loss of sensation, especially tactile sensation and pain. They may act to induce general ANESTHESIA, in which an unconscious state is achieved, or may act locally to induce numbness or lack of sensation at a targeted site.
Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
Rapid and excessive rise of temperature accompanied by muscular rigidity following general anesthesia.
A very strong halogenated derivative of acetic acid. It is used in acid catalyzed reactions, especially those where an ester is cleaved in peptide synthesis.
A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration.
'Ethers' in a medical context are a class of organic compounds used as medication, particularly as an inhalational agent to induce and maintain general anesthesia, characterized by their ability to produce a state of unconsciousness while providing muscle relaxation and analgesia.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
The decrease in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.
A mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums. It is mildly irritating to skin and mucous membranes.
An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with NITROUS OXIDE to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180)
"Ethyl ethers, also known as diethyl ether, is a colorless, highly volatile, and flammable liquid that belongs to the class of organic compounds called ethers, used as an anesthetic in medicine."
Procedure in which patients are induced into an unconscious state through use of various medications so that they do not feel pain during surgery.
A series of hydrocarbons containing both chlorine and fluorine. These have been used as refrigerants, blowing agents, cleaning fluids, solvents, and as fire extinguishing agents. They have been shown to cause stratospheric ozone depletion and have been banned for many uses.
Halogenated hydrocarbons refer to organic compounds containing carbon and hydrogen atoms, where one or more hydrogen atoms are replaced by halogens such as fluorine, chlorine, bromine, or iodine.
Agents that induce various degrees of analgesia; depression of consciousness, circulation, and respiration; relaxation of skeletal muscle; reduction of reflex activity; and amnesia. There are two types of general anesthetics, inhalation and intravenous. With either type, the arterial concentration of drug required to induce anesthesia varies with the condition of the patient, the desired depth of anesthesia, and the concomitant use of other drugs. (From AMA Drug Evaluations Annual, 1994, p.173)
A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
The relationship between the dose of an administered drug and the response of the organism to the drug.
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment.
A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for.
The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).
Procedure in which arterial blood pressure is intentionally reduced in order to control blood loss during surgery. This procedure is performed either pharmacologically or by pre-surgical removal of blood.
Derivatives of acetic acid with one or more fluorines attached. They are almost odorless, difficult to detect chemically, and very stable. The acid itself, as well as the derivatives that are broken down in the body to the acid, are highly toxic substances, behaving as convulsant poisons with a delayed action. (From Miall's Dictionary of Chemistry, 5th ed)
A barbiturate that is administered intravenously for the production of complete anesthesia of short duration, for the induction of general anesthesia, or for inducing a hypnotic state. (From Martindale, The Extra Pharmacopoeia, 30th ed, p919)
Intratracheal anesthesia is a technique where anesthetic agents are directly instilled into the trachea to induce or maintain general anesthesia, often used in emergency situations, veterinary medicine, or when conventional methods of administration are not feasible.

Mutation screening of the RYR1 gene and identification of two novel mutations in Italian malignant hyperthermia families. (1/1763)

Point mutations in the ryanodine receptor (RYR1) gene are associated with malignant hyperthermia, an autosomal dominant disorder triggered in susceptible people (MHS) by volatile anaesthetics and depolarising skeletal muscle relaxants. To date, 17 missense point mutations have been identified in the human RYR1 gene by screening of the cDNA obtained from muscle biopsies. Here we report single strand conformation polymorphism (SSCP) screening for nine of the most frequent RYR1 mutations using genomic DNA isolated from MHS patients. In addition, the Argl63Cys mutation was analysed by restriction enzyme digestion. We analysed 57 unrelated patients and detected seven of the known RYR1 point mutations. Furthermore, we found a new mutation, Arg2454His, segregating with the MHS phenotype in a large pedigree and a novel amino acid substitution at position 2436 in another patient, indicating a 15.8% frequency of these mutations in Italian patients. A new polymorphic site in intron 16 that causes the substitution of a G at position -7 with a C residue was identified.  (+info)

A neomorphic syntaxin mutation blocks volatile-anesthetic action in Caenorhabditis elegans. (2/1763)

The molecular mechanisms underlying general anesthesia are unknown. For volatile general anesthetics (VAs), indirect evidence for both lipid and protein targets has been found. However, no in vivo data have implicated clearly any particular lipid or protein in the control of sensitivity to clinical concentrations of VAs. Genetics provides one approach toward identifying these mechanisms, but genes strongly regulating sensitivity to clinical concentrations of VAs have not been identified. By screening existing mutants of the nematode Caenorhabditis elegans, we found that a mutation in the neuronal syntaxin gene dominantly conferred resistance to the VAs isoflurane and halothane. By contrast, other mutations in syntaxin and in the syntaxin-binding proteins synaptobrevin and SNAP-25 produced VA hypersensitivity. The syntaxin allelic variation was striking, particularly for isoflurane, where a 33-fold range of sensitivities was seen. Both the resistant and hypersensitive mutations decrease synaptic transmission; thus, the indirect effect of reducing neurotransmission does not explain the VA resistance. As assessed by pharmacological criteria, halothane and isoflurane themselves reduced cholinergic transmission, and the presynaptic anesthetic effect was blocked by the resistant syntaxin mutation. A single gene mutation conferring high-level resistance to VAs is inconsistent with nonspecific membrane-perturbation theories of anesthesia. The genetic and pharmacological data suggest that the resistant syntaxin mutant directly blocks VA binding to or efficacy against presynaptic targets that mediate anesthetic behavioral effects. Syntaxin and syntaxin-binding proteins are candidate anesthetic targets.  (+info)

Functional brain imaging during anesthesia in humans: effects of halothane on global and regional cerebral glucose metabolism. (3/1763)

BACKGROUND: Propofol and isoflurane anesthesia were studied previously with functional brain imaging in humans to begin identifying key brain areas involved with mediating anesthetic-induced unconsciousness. The authors describe an additional positron emission tomography study of halothane's in vivo cerebral metabolic effects. METHODS: Five male volunteers each underwent two positron emission tomography scans. One scan assessed awake-baseline metabolism, and the other scan assessed metabolism during halothane anesthesia titrated to the point of unresponsiveness (mean +/- SD, expired = 0.7+/-0.2%). Scans were obtained using a GE2048 scanner and the F-18 fluorodeoxyglucose technique. Regions of interest were analyzed for changes in both absolute and relative glucose metabolism. In addition, relative changes in metabolism were evaluated using statistical parametric mapping. RESULTS: Awake whole-brain metabolism averaged 6.3+/-1.2 mg x 100 g(-1) x min(-1) (mean +/- SD). Halothane reduced metabolism 40+/-9% to 3.7+/-0.6 mg x 100 g(-1) x min(-1) (P< or =0.005). Regional metabolism did not increase in any brain areas for any volunteer. The statistical parametric mapping analysis revealed significantly less relative metabolism in the basal forebrain, thalamus, limbic system, cerebellum, and occiput during halothane anesthesia. CONCLUSIONS: Halothane caused a global whole-brain metabolic reduction with significant shifts in regional metabolism. Comparisons with previous studies reveal similar absolute and relative metabolic effects for halothane and isoflurane. Propofol, however, was associated with larger absolute metabolic reductions, suppression of relative cortical metabolism more than either inhalational agent, and significantly less suppression of relative basal ganglia and midbrain metabolism.  (+info)

Primary and secondary hyperalgesia in a rat model for human postoperative pain. (4/1763)

BACKGROUND: Previously, the authors developed and characterized a rat model for postoperative pain to learn more about pain produced by incisions. In this study, the responses to heat and mechanical stimuli were evaluated directly on or adjacent to the incision and at varying distances from the incision. METHODS: Rats were anesthetized with halothane and incisions were made at different locations in the plantar aspect of the foot. The response frequency to a blunt mechanical stimulus, the withdrawal threshold to von Frey filaments (15-522 mN), and the withdrawal latency to radiant heat were measured. Rats were tested before surgery, 2 h later, and then daily through postoperative day 9. RESULTS: After plantar incision, persistent hyperalgesia was observed immediately adjacent to or directly on the incision to punctate and blunt mechanical stimuli, respectively. The withdrawal threshold to punctate stimuli applied 1 cm from the incision was decreased through postoperative day 1. In a transitional area, between the distant and adjacent sites, the withdrawal threshold was intermediate and the duration of hyperalgesia was transient. Heat hyperalgesia was persistent but present when the stimulus was applied to the site of injury but not to a distant site. CONCLUSION: Robust primary hyperalgesia to punctate and blunt mechanical stimuli was present. Hyperalgesia distant to the wound, or secondary hyperalgesia, occurred in response to punctate mechanical stimuli, was short-lived, and required greater forces. These results suggest that the most persistent pain behaviors in this model are largely primary hyperalgesia.  (+info)

Halothane, an inhalational anesthetic agent, increases folding stability of serum albumin. (5/1763)

Inhalational anesthetic agents are known to alter protein function, but the nature of the interactions underlying these effects remains poorly understood. We have used differential scanning calorimetry to study the effects of the anesthetic agent halothane on the thermally induced unfolding transition of bovine serum albumin. We find that halothane (0.6-10 mM) stabilizes the folded state of this protein, increasing its transition midpoint temperature from 62 to 71 degrees C. Binding of halothane to the native state of serum albumin thus outweighs any non-specific interactions between the thermally unfolded state of serum albumin and halothane in this concentration range. Based on the average enthalpy change DeltaH for unfolding of 170 kcal/mol, the increase from 62 to 71 degrees C corresponds to an additional Gibbs energy of stabilization (DeltaDeltaG) due to halothane of more than 4 kcal/mol. Analysis of the dependence of DeltaDeltaG on halothane concentration shows that thermal unfolding of a bovine serum albumin molecule is linked to the dissociation of about one halothane molecule at lower halothane concentrations and about six at higher halothane concentrations. Serum albumin is the first protein that has been shown to be stabilized by an inhalational anesthetic.  (+info)

A mutation in the transmembrane/luminal domain of the ryanodine receptor is associated with abnormal Ca2+ release channel function and severe central core disease. (6/1763)

Central core disease is a rare, nonprogressive myopathy that is characterized by hypotonia and proximal muscle weakness. In a large Mexican kindred with an unusually severe and highly penetrant form of the disorder, DNA sequencing identified an I4898T mutation in the C-terminal transmembrane/luminal region of the RyR1 protein that constitutes the skeletal muscle ryanodine receptor. All previously reported RYR1 mutations are located either in the cytoplasmic N terminus or in a central cytoplasmic region of the 5,038-aa protein. The I4898T mutation was introduced into a rabbit RYR1 cDNA and expressed in HEK-293 cells. The response of the mutant RyR1 Ca2+ channel to the agonists halothane and caffeine in a Ca2+ photometry assay was completely abolished. Coexpression of normal and mutant RYR1 cDNAs in a 1:1 ratio, however, produced RyR1 channels with normal halothane and caffeine sensitivities, but maximal levels of Ca2+ release were reduced by 67%. [3H]Ryanodine binding indicated that the heterozygous channel is activated by Ca2+ concentrations 4-fold lower than normal. Single-cell analysis of cotransfected cells showed a significantly increased resting cytoplasmic Ca2+ level and a significantly reduced luminal Ca2+ level. These data are indicative of a leaky channel, possibly caused by a reduction in the Ca2+ concentration required for channel activation. Comparison with two other coexpressed mutant/normal channels suggests that the I4898T mutation produces one of the most abnormal RyR1 channels yet investigated, and this level of abnormality is reflected in the severe and penetrant phenotype of affected central core disease individuals.  (+info)

Effects of the halothane genotype and slaughter weight on texture of pork. (7/1763)

The objective of this study was to investigate the effects of the halothane (HAL) genotype, slaughter weight (SW), and the HAL x SW interaction on compositional and textural traits of raw and cooked pork. Pigs were bred to exhibit one of the three HAL genotypes (NN, Nn, and nn) with otherwise equivalent genomes. The nn halothane reactors are known to typically produce PSE pork, whereas NN pigs do not typically produce PSE pork. Pietrain x Large White gilts and boars, all with verified Nn genotype (by DNA test), were mated to obtain F2 littermates of the three HAL genotypes. These pigs were slaughtered at either 101 +/- 3 ("light") or 127 +/- 3 ("heavy") kg BW and were evaluated for longissimus muscle traits. The pH at .5 h after death (pH1) was 6.35, 6.13, and 5.68 in NN, Nn, and nn pigs, respectively. Sarcomere length was greater in nn than in NN and Nn pigs (1.94 vs 1.83 and 1.85 microm, respectively). Mechanical resistance was higher in nn than in NN pigs for both raw and cooked meat. Meat from nn pigs was judged by a trained panel to be less rough, more cohesive, harder, more fibrous, less granular, more elastic, and less easy to swallow than meat from NN pigs. For most traits under study, the heterozygotes were intermediate between the homozygotes but closer to NN than to nn pigs. Muscle from heavy pigs had longer sarcomeres and less moisture than muscle from light pigs. The n allele of the HAL gene unfavorably affects pork texture, and this effect is maintained throughout the range of 101 to 127 kg BW.  (+info)

Halothane effect on formalin-induced paw edema and flinching in rat. (8/1763)

The formalin test is a model of injury-produced inflammatory pain. Anesthetics, in clinically relevant concentrations, affect neutrophils and immune suppression. This study was to determine whether halothane reliably inhibits inflammatory reaction and formalin induced pain behavior or does not. Rats were exposed to 100% oxygen (control) or halothane, respectively for 30 min and then 24 hr later five percent formalin test was assessed. The base values of the paw's diameter were obtained earlier, and then formalin induced edema was assessed by measuring diameters of the injected paws at 5 min, 1 hr, 4 hr and 24 hr after the injection. Nociceptive behavior was quantified by counting the number of times with the paw flinched at 5 min intervals for 60 min. The diameters of edema in the halothane group lessened more than those in the oxygen group at 1 and 24 hr in each following of the injection (p<0.05). The rats pre-administered with oxygen or halothane were similar appearances in nociceptive behaviors. It suggests that halothane anesthesia might inhibit slightly the inflammatory reaction with the formalin-induced edema but might not inhibit the formalin-induced pain behavior in the event of pre-administration halothane 24 hr earlier before the formalin test of rat.  (+info)

Halothane is a general anesthetic agent, which is a volatile liquid that evaporates easily and can be inhaled. It is used to produce and maintain general anesthesia (a state of unconsciousness) during surgical procedures. Halothane is known for its rapid onset and offset of action, making it useful for both induction and maintenance of anesthesia.

The medical definition of Halothane is:

Halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) is a volatile liquid general anesthetic agent with a mild, sweet odor. It is primarily used for the induction and maintenance of general anesthesia in surgical procedures due to its rapid onset and offset of action. Halothane is administered via inhalation and acts by depressing the central nervous system, leading to a reversible loss of consciousness and analgesia.

It's important to note that Halothane has been associated with rare cases of severe liver injury (hepatotoxicity) and anaphylaxis (a severe, life-threatening allergic reaction). These risks have led to the development and use of alternative general anesthetic agents with better safety profiles.

Inhalational anesthetics are a type of general anesthetic that is administered through the person's respiratory system. They are typically delivered in the form of vapor or gas, which is inhaled through a mask or breathing tube. Commonly used inhalational anesthetics include sevoflurane, desflurane, isoflurane, and nitrous oxide. These agents work by depressing the central nervous system, leading to a loss of consciousness and an inability to feel pain. They are often used for their rapid onset and offset of action, making them useful for both induction and maintenance of anesthesia during surgical procedures.

Inhalational anesthesia is a type of general anesthesia that is induced by the inhalation of gases or vapors. It is administered through a breathing system, which delivers the anesthetic agents to the patient via a face mask, laryngeal mask airway, or endotracheal tube.

The most commonly used inhalational anesthetics include nitrous oxide, sevoflurane, isoflurane, and desflurane. These agents work by depressing the central nervous system, causing a reversible loss of consciousness, amnesia, analgesia, and muscle relaxation.

The depth of anesthesia can be easily adjusted during the procedure by changing the concentration of the anesthetic agent. Once the procedure is complete, the anesthetic agents are eliminated from the body through exhalation, allowing for a rapid recovery.

Inhalational anesthesia is commonly used in a wide range of surgical procedures due to its ease of administration, quick onset and offset of action, and ability to rapidly adjust the depth of anesthesia. However, it requires careful monitoring and management by trained anesthesia providers to ensure patient safety and optimize outcomes.

Isoflurane is a volatile halogenated ether used for induction and maintenance of general anesthesia. It is a colorless liquid with a pungent, sweet odor. Isoflurane is an agonist at the gamma-aminobutyric acid type A (GABAA) receptor and inhibits excitatory neurotransmission in the brain, leading to unconsciousness and immobility. It has a rapid onset and offset of action due to its low blood solubility, allowing for quick adjustments in anesthetic depth during surgery. Isoflurane is also known for its bronchodilator effects, making it useful in patients with reactive airway disease. However, it can cause dose-dependent decreases in heart rate and blood pressure, so careful hemodynamic monitoring is required during its use.

Enflurane is a volatile halogenated ether that was commonly used as an inhalational general anesthetic agent. Its chemical formula is C3H2ClF5O. It has been largely replaced by newer and safer anesthetics, but it is still occasionally used in certain clinical situations due to its favorable properties such as rapid onset and offset of action, stable hemodynamics, and low blood solubility. However, it can cause adverse effects such as respiratory depression, arrhythmias, and neurotoxicity, particularly with prolonged use or high doses. Therefore, its use requires careful monitoring and management by anesthesia professionals.

Methyl ethers are a type of organic compound where a methyl group (CH3-) is attached to an oxygen atom, which in turn is connected to another carbon atom. They are formed by the process of methylation, where a methyl group replaces a hydrogen atom in another molecule.

Methyl ethers can be found in various natural and synthetic substances. For example, dimethyl ether (CH3-O-CH3) is a common fuel used in refrigeration systems and as a propellant in aerosol sprays. Anisole (CH3-O-C6H5), another methyl ether, is found in anise oil and is used as a flavoring agent and solvent.

It's worth noting that some methyl ethers have been associated with potential health risks, particularly when they are volatile and can be inhaled or ingested. For example, exposure to high levels of dimethyl ether can cause respiratory irritation, headaches, and dizziness. Therefore, it's important to handle these substances with care and follow appropriate safety guidelines.

Anesthetics are medications that are used to block or reduce feelings of pain and sensation, either locally in a specific area of the body or generally throughout the body. They work by depressing the nervous system, interrupting the communication between nerves and the brain. Anesthetics can be administered through various routes such as injection, inhalation, or topical application, depending on the type and the desired effect. There are several classes of anesthetics, including:

1. Local anesthetics: These numb a specific area of the body and are commonly used during minor surgical procedures, dental work, or to relieve pain from injuries. Examples include lidocaine, prilocaine, and bupivacaine.
2. Regional anesthetics: These block nerve impulses in a larger area of the body, such as an arm or leg, and can be used for more extensive surgical procedures. They are often administered through a catheter to provide continuous pain relief over a longer period. Examples include spinal anesthesia, epidural anesthesia, and peripheral nerve blocks.
3. General anesthetics: These cause a state of unconsciousness and are used for major surgical procedures or when the patient needs to be completely immobile during a procedure. They can be administered through inhalation or injection and affect the entire body. Examples include propofol, sevoflurane, and isoflurane.

Anesthetics are typically safe when used appropriately and under medical supervision. However, they can have side effects such as drowsiness, nausea, and respiratory depression. Proper dosing and monitoring by a healthcare professional are essential to minimize the risks associated with anesthesia.

Nitrous oxide, also known as laughing gas, is a colorless and non-flammable gas with a slightly sweet odor and taste. In medicine, it's commonly used for its anesthetic and pain reducing effects. It is often used in dental procedures, surgery, and childbirth to help reduce anxiety and provide mild sedation. Nitrous oxide works by binding to the hemoglobin in red blood cells, which reduces the oxygen-carrying capacity of the blood, but this effect is usually not significant at the low concentrations used for analgesia and anxiolysis. It's also considered relatively safe when administered by a trained medical professional because it does not cause depression of the respiratory system or cardiovascular function.

Malignant hyperthermia (MH) is a rare, but potentially life-threatening genetic disorder that can occur in susceptible individuals as a reaction to certain anesthetic drugs or other triggers. The condition is characterized by a rapid and uncontrolled increase in body temperature (hyperthermia), muscle rigidity, and metabolic rate due to abnormal skeletal muscle calcium regulation.

MH can develop quickly during or after surgery, usually within the first hour of exposure to triggering anesthetics such as succinylcholine or volatile inhalational agents (e.g., halothane, sevoflurane, desflurane). The increased metabolic rate and muscle activity lead to excessive production of heat, carbon dioxide, lactic acid, and potassium, which can cause severe complications such as heart rhythm abnormalities, kidney failure, or multi-organ dysfunction if not promptly recognized and treated.

The primary treatment for MH involves discontinuing triggering anesthetics, providing supportive care (e.g., oxygen, fluid replacement), and administering medications to reduce body temperature, muscle rigidity, and metabolic rate. Dantrolene sodium is the specific antidote for MH, which works by inhibiting calcium release from the sarcoplasmic reticulum in skeletal muscle cells, thereby reducing muscle contractility and metabolism.

Individuals with a family history of MH or who have experienced an episode should undergo genetic testing and counseling to determine their susceptibility and take appropriate precautions when receiving anesthesia.

Trifluoroacetic acid (TFA) is not typically considered a medical term, but rather a chemical one. However, it does have relevance to the medical field in certain contexts, such as in laboratory settings or pharmaceutical manufacturing. Here's a definition of TFA:

Trifluoroacetic acid (C2HF3O2) is an inorganic compound that is a colorless liquid at room temperature. It has a strong, pungent odor and is highly corrosive. In the chemical industry, it is commonly used as a reagent or solvent due to its ability to dissolve a wide range of organic compounds.

In the medical field, TFA may be encountered in laboratory settings where it can be used for various purposes such as peptide synthesis, chromatography, and other chemical reactions. It is also sometimes used as an ingredient in certain pharmaceutical formulations, although its use is generally limited due to its potential toxicity.

It's worth noting that TFA is not a medication or drug, but rather a chemical compound with various industrial and laboratory applications.

Thiopental, also known as Thiopentone, is a rapid-onset, ultrashort-acting barbiturate derivative. It is primarily used for the induction of anesthesia due to its ability to cause unconsciousness quickly and its short duration of action. Thiopental can also be used for sedation in critically ill patients, though this use has become less common due to the development of safer alternatives.

The drug works by enhancing the inhibitory effects of gamma-aminobutyric acid (GABA), a neurotransmitter in the brain that produces a calming effect. This results in the depression of the central nervous system, leading to sedation, hypnosis, and ultimately, anesthesia.

It is worth noting that Thiopental has been largely replaced by newer drugs in many clinical settings due to its potential for serious adverse effects, such as cardiovascular and respiratory depression, as well as the risk of anaphylaxis. Additionally, it has been used in controversial procedures like capital punishment in some jurisdictions.

In medical or clinical terms, "ethers" do not have a specific relevance as a single medical condition or diagnosis. However, in a broader chemical context, ethers are a class of organic compounds characterized by an oxygen atom connected to two alkyl or aryl groups. Ethers are not typically used as therapeutic agents but can be found in certain medications as solvents or as part of the drug's chemical structure.

An example of a medication with an ether group is the antihistamine diphenhydramine (Benadryl), which has a phenyl ether moiety in its chemical structure. Another example is the anesthetic sevoflurane, which is a fluorinated methyl isopropyl ether used for inducing and maintaining general anesthesia during surgeries.

It's important to note that 'ethers' as a term primarily belongs to the field of chemistry rather than medicine.

I believe there might be a misunderstanding in your question. "Dogs" is not a medical term or condition. It is the common name for a domesticated carnivore of the family Canidae, specifically the genus Canis, which includes wolves, foxes, and other extant and extinct species of mammals. Dogs are often kept as pets and companions, and they have been bred in a wide variety of forms and sizes for different purposes, such as hunting, herding, guarding, assisting police and military forces, and providing companionship and emotional support.

If you meant to ask about a specific medical condition or term related to dogs, please provide more context so I can give you an accurate answer.

Anesthesia is a medical term that refers to the loss of sensation or awareness, usually induced by the administration of various drugs. It is commonly used during surgical procedures to prevent pain and discomfort. There are several types of anesthesia, including:

1. General anesthesia: This type of anesthesia causes a complete loss of consciousness and is typically used for major surgeries.
2. Regional anesthesia: This type of anesthesia numbs a specific area of the body, such as an arm or leg, while the patient remains conscious.
3. Local anesthesia: This type of anesthesia numbs a small area of the body, such as a cut or wound, and is typically used for minor procedures.

Anesthesia can be administered through various routes, including injection, inhalation, or topical application. The choice of anesthesia depends on several factors, including the type and duration of the procedure, the patient's medical history, and their overall health. Anesthesiologists are medical professionals who specialize in administering anesthesia and monitoring patients during surgical procedures to ensure their safety and comfort.

I couldn't find a medical definition for "Depression, Chemical" as it is not a recognized medical term. However, I can provide you with information about chemical imbalances in the brain that are associated with depression.

Major depressive disorder (MDD), commonly referred to as depression, is believed to be caused by a combination of genetic, environmental, and physiological factors. While there is no definitive evidence that depression is solely caused by a "chemical imbalance," neurotransmitter irregularities in the brain are associated with depressive symptoms. Neurotransmitters are chemical messengers that transmit signals in the brain and other parts of the body. Some of the primary neurotransmitters involved in mood regulation include serotonin, norepinephrine, and dopamine.

In depression, it is thought that there may be alterations in the functioning of these neurotransmitter systems, leading to an imbalance. For example:

1. Serotonin: Low levels of serotonin are associated with depressive symptoms. Selective serotonin reuptake inhibitors (SSRIs), a common class of antidepressants, work by increasing the availability of serotonin in the synapse (the space between neurons) to improve communication between brain cells.
2. Norepinephrine: Imbalances in norepinephrine levels can contribute to depressive symptoms and anxiety. Norepinephrine reuptake inhibitors (NRIs), tricyclic antidepressants (TCAs), and monoamine oxidase inhibitors (MAOIs) are medications that target norepinephrine to help alleviate depression.
3. Dopamine: Deficiencies in dopamine can lead to depressive symptoms, anhedonia (the inability to feel pleasure), and motivation loss. Some antidepressants, like bupropion, work by increasing dopamine levels in the brain.

In summary, while "Chemical Depression" is not a recognized medical term, chemical imbalances in neurotransmitter systems are associated with depressive symptoms. However, depression is a complex disorder that cannot be solely attributed to a single cause or a simple chemical imbalance. It is essential to consider multiple factors when diagnosing and treating depression.

In medical terms, "ether" is an outdated term that was used to refer to a group of compounds known as diethyl ethers. The most common member of this group, and the one most frequently referred to as "ether," is diethyl ether, also known as sulfuric ether or simply ether.

Diethyl ether is a highly volatile, flammable liquid that was once widely used as an anesthetic agent in surgical procedures. It has a characteristic odor and produces a state of unconsciousness when inhaled, allowing patients to undergo surgery without experiencing pain. However, due to its numerous side effects, such as nausea, vomiting, and respiratory depression, as well as the risk of explosion or fire during use, it has largely been replaced by safer and more effective anesthetic agents.

It's worth noting that "ether" also has other meanings in different contexts, including a term used to describe a substance that produces a feeling of detachment from reality or a sense of unreality, as well as a class of organic compounds characterized by the presence of an ether group (-O-, a functional group consisting of an oxygen atom bonded to two alkyl or aryl groups).

Methoxyflurane is a sweet-smelling, volatile liquid that is used as an inhalational general anesthetic agent. It is chemically described as 2,2-dichloro-1,1-difluoro-1-methoxyethane. Methoxyflurane is a fluorinated hydrocarbon with low blood/gas solubility, which allows for rapid induction and emergence from anesthesia. It has been used for the induction and maintenance of anesthesia in both adults and children. However, its use has been limited due to concerns about nephrotoxicity associated with high concentrations or prolonged exposure.

Ethyl ether, also known as diethyl ether or simply ether, is a type of organic compound that is classified as a simple ether. It is a colorless and highly volatile liquid with a characteristic odor that is often described as sweet or fruity. In medical contexts, ethyl ether has been historically used as an anesthetic agent due to its ability to produce unconsciousness and insensitivity to pain when inhaled. However, its use as an anesthetic has largely been replaced by safer and more effective alternatives due to its flammability, explosiveness, and potential for causing serious adverse effects such as heart problems and liver damage.

Ethyl ether is a simple ether consisting of two ethyl groups (-C2H5) linked to an oxygen atom (O), with the molecular formula C4H10O. It is produced by the reaction of ethanol with sulfuric acid, followed by distillation to separate the resulting ethyl ether from other products.

In addition to its historical use as an anesthetic, ethyl ether has been used in various industrial and laboratory applications, such as a solvent for fats, oils, resins, and waxes, and as a starting material for the synthesis of other chemicals. However, due to its flammability and potential for causing harm, it is important to handle ethyl ether with care and follow appropriate safety precautions when using it.

General anesthesia is a state of controlled unconsciousness, induced by administering various medications, that eliminates awareness, movement, and pain sensation during medical procedures. It involves the use of a combination of intravenous and inhaled drugs to produce a reversible loss of consciousness, allowing patients to undergo surgical or diagnostic interventions safely and comfortably. The depth and duration of anesthesia are carefully monitored and adjusted throughout the procedure by an anesthesiologist or certified registered nurse anesthetist (CRNA) to ensure patient safety and optimize recovery. General anesthesia is typically used for more extensive surgical procedures, such as open-heart surgery, major orthopedic surgeries, and neurosurgery.

Chlorofluorocarbons (CFCs) are synthetic, volatile organic compounds that consist of carbon atoms, chlorine atoms, and fluorine atoms. They were widely used in various applications such as refrigerants, aerosol propellants, solvents, and fire extinguishing agents due to their non-toxicity, non-flammability, and chemical stability.

However, CFCs have been found to contribute significantly to the depletion of the Earth's ozone layer when released into the atmosphere. This is because they are stable enough to reach the upper atmosphere, where they react with ultraviolet radiation to release chlorine atoms that can destroy ozone molecules. As a result, the production and use of CFCs have been phased out under the Montreal Protocol, an international treaty aimed at protecting the ozone layer.

Halogenated hydrocarbons are organic compounds containing carbon (C), hydrogen (H), and one or more halogens, such as fluorine (F), chlorine (Cl), bromine (Br), or iodine (I). These compounds are formed when halogens replace one or more hydrogen atoms in a hydrocarbon molecule.

Halogenated hydrocarbons can be further categorized into two groups:

1. Halogenated aliphatic hydrocarbons: These include alkanes, alkenes, and alkynes with halogen atoms replacing hydrogen atoms. Examples include chloroform (trichloromethane, CHCl3), methylene chloride (dichloromethane, CH2Cl2), and trichloroethylene (C2HCl3).
2. Halogenated aromatic hydrocarbons: These consist of aromatic rings, such as benzene, with halogen atoms attached. Examples include chlorobenzene (C6H5Cl), bromobenzene (C6H5Br), and polyhalogenated biphenyls like polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs).

Halogenated hydrocarbons have various industrial applications, including use as solvents, refrigerants, fire extinguishing agents, and intermediates in chemical synthesis. However, some of these compounds can be toxic, environmentally persistent, and bioaccumulative, posing potential health and environmental risks.

General anesthetics are a type of medication used to render a person unconscious and insensible to pain during surgical procedures. They work by depressing the central nervous system, affecting the brain's ability to process information and transmit signals, including those related to pain and muscle movement. General anesthesia involves a combination of intravenous (IV) drugs and inhaled gases that produce a state of controlled unconsciousness, amnesia, analgesia, and immobility.

General anesthetics can be classified into several categories based on their chemical structure and mechanism of action, including:

1. Inhalation anesthetics: These are volatile liquids or gases that are vaporized and inhaled through a breathing circuit. Examples include sevoflurane, desflurane, isoflurane, and nitrous oxide.
2. Intravenous anesthetics: These are drugs that are administered directly into the bloodstream through an IV line. Examples include propofol, etomidate, and ketamine.
3. Dissociative anesthetics: These are drugs that produce a state of dissociation between the thalamus and the cerebral cortex, resulting in altered consciousness, analgesia, and amnesia. Ketamine is a commonly used example.
4. Neurodegenerative anesthetics: These are drugs that cause degeneration of neurons in specific areas of the brain, leading to loss of consciousness. Examples include barbiturates such as thiopental and methohexital.

The choice of general anesthetic depends on several factors, including the patient's medical history, the type and duration of surgery, and the anesthesiologist's preference. The administration of general anesthetics requires careful monitoring and management by a trained anesthesia provider to ensure the patient's safety and comfort throughout the procedure.

Pentobarbital is a barbiturate medication that is primarily used for its sedative and hypnotic effects in the treatment of insomnia, seizure disorders, and occasionally to treat severe agitation or delirium. It works by decreasing the activity of nerves in the brain, which produces a calming effect.

In addition to its medical uses, pentobarbital has been used for non-therapeutic purposes such as euthanasia and capital punishment due to its ability to cause respiratory depression and death when given in high doses. It is important to note that the use of pentobarbital for these purposes is highly regulated and restricted to licensed medical professionals in specific circumstances.

Like all barbiturates, pentobarbital has a high potential for abuse and addiction, and its use should be closely monitored by a healthcare provider. It can also cause serious side effects such as respiratory depression, decreased heart rate, and low blood pressure, especially when used in large doses or combined with other central nervous system depressants.

A dose-response relationship in the context of drugs refers to the changes in the effects or symptoms that occur as the dose of a drug is increased or decreased. Generally, as the dose of a drug is increased, the severity or intensity of its effects also increases. Conversely, as the dose is decreased, the effects of the drug become less severe or may disappear altogether.

The dose-response relationship is an important concept in pharmacology and toxicology because it helps to establish the safe and effective dosage range for a drug. By understanding how changes in the dose of a drug affect its therapeutic and adverse effects, healthcare providers can optimize treatment plans for their patients while minimizing the risk of harm.

The dose-response relationship is typically depicted as a curve that shows the relationship between the dose of a drug and its effect. The shape of the curve may vary depending on the drug and the specific effect being measured. Some drugs may have a steep dose-response curve, meaning that small changes in the dose can result in large differences in the effect. Other drugs may have a more gradual dose-response curve, where larger changes in the dose are needed to produce significant effects.

In addition to helping establish safe and effective dosages, the dose-response relationship is also used to evaluate the potential therapeutic benefits and risks of new drugs during clinical trials. By systematically testing different doses of a drug in controlled studies, researchers can identify the optimal dosage range for the drug and assess its safety and efficacy.

Drug-Induced Liver Injury (DILI) is a medical term that refers to liver damage or injury caused by the use of medications or drugs. This condition can vary in severity, from mild abnormalities in liver function tests to severe liver failure, which may require a liver transplant.

The exact mechanism of DILI can differ depending on the drug involved, but it generally occurs when the liver metabolizes the drug into toxic compounds that damage liver cells. This can happen through various pathways, including direct toxicity to liver cells, immune-mediated reactions, or metabolic idiosyncrasies.

Symptoms of DILI may include jaundice (yellowing of the skin and eyes), fatigue, abdominal pain, nausea, vomiting, loss of appetite, and dark urine. In severe cases, it can lead to complications such as ascites, encephalopathy, and bleeding disorders.

The diagnosis of DILI is often challenging because it requires the exclusion of other potential causes of liver injury. Liver function tests, imaging studies, and sometimes liver biopsies may be necessary to confirm the diagnosis. Treatment typically involves discontinuing the offending drug and providing supportive care until the liver recovers. In some cases, medications that protect the liver or promote its healing may be used.

Succinylcholine is a neuromuscular blocking agent, a type of muscle relaxant used in anesthesia during surgical procedures. It works by inhibiting the transmission of nerve impulses at the neuromuscular junction, leading to temporary paralysis of skeletal muscles. This facilitates endotracheal intubation and mechanical ventilation during surgery. Succinylcholine has a rapid onset of action and is metabolized quickly, making it useful for short surgical procedures. However, its use may be associated with certain adverse effects, such as increased heart rate, muscle fasciculations, and potentially life-threatening hyperkalemia in susceptible individuals.

Medical Definition of Respiration:

Respiration, in physiology, is the process by which an organism takes in oxygen and gives out carbon dioxide. It's also known as breathing. This process is essential for most forms of life because it provides the necessary oxygen for cellular respiration, where the cells convert biochemical energy from nutrients into adenosine triphosphate (ATP), and releases waste products, primarily carbon dioxide.

In humans and other mammals, respiration is a two-stage process:

1. Breathing (or external respiration): This involves the exchange of gases with the environment. Air enters the lungs through the mouth or nose, then passes through the pharynx, larynx, trachea, and bronchi, finally reaching the alveoli where the actual gas exchange occurs. Oxygen from the inhaled air diffuses into the blood, while carbon dioxide, a waste product of metabolism, diffuses from the blood into the alveoli to be exhaled.

2. Cellular respiration (or internal respiration): This is the process by which cells convert glucose and other nutrients into ATP, water, and carbon dioxide in the presence of oxygen. The carbon dioxide produced during this process then diffuses out of the cells and into the bloodstream to be exhaled during breathing.

In summary, respiration is a vital physiological function that enables organisms to obtain the necessary oxygen for cellular metabolism while eliminating waste products like carbon dioxide.

Controlled hypotension is a medical procedure in which the healthcare provider intentionally lowers the patient's blood pressure during surgery. This is done to reduce bleeding and improve surgical conditions. The goal is to maintain the patient's blood pressure at a level that is lower than their normal resting blood pressure, but high enough to ensure adequate blood flow to vital organs such as the heart and brain. Controlled hypotension is closely monitored and managed throughout the surgery to minimize risks and ensure the best possible outcomes for the patient.

Fluoroacetates are organic compounds that contain a fluorine atom and an acetic acid group. The most well-known and notorious compound in this family is sodium fluoroacetate, also known as 1080 or compound 1080, which is a potent metabolic poison. It works by interfering with the citric acid cycle, a critical process that generates energy in cells. Specifically, fluoroacetates are converted into fluorocitrate, which inhibits an enzyme called aconitase, leading to disruption of cellular metabolism and ultimately cell death.

Fluoroacetates have been used as rodenticides and pesticides, but their use is highly regulated due to their high toxicity to non-target species, including humans. Exposure to fluoroacetates can cause a range of symptoms, including nausea, vomiting, seizures, and cardiac arrest, and can be fatal if not treated promptly.

Thiamylal is a fast-acting, ultra-short-acting barbiturate drug that is primarily used for the induction of anesthesia before surgical procedures. It works by depressing the central nervous system, producing sedation, relaxation, and hypnosis. Thiamylal has a rapid onset of action and its effects last only a short time, making it useful for quickly achieving a desired level of anesthesia while minimizing the risk of prolonged sedation or respiratory depression.

It is important to note that thiamylal should be administered under the close supervision of trained medical personnel, as its use carries certain risks and potential complications, such as cardiovascular and respiratory depression. Additionally, patients with a history of drug allergies, liver or kidney disease, or other medical conditions may require special precautions before receiving thiamylal.

Intratracheal anesthesia refers to the administration of anesthetic agents directly into the trachea. This type of anesthesia is typically used in specific medical procedures, such as bronchoscopy or airway surgery, where it is necessary to achieve adequate anesthesia and analgesia of the airways while avoiding systemic effects.

Intratracheal anesthesia is usually delivered through a specialized device called a laryngoscope, which is used to visualize the vocal cords and introduce a narrow tube (endotracheal tube) into the trachea. Once the endotracheal tube is in place, anesthetic gases or liquids can be administered directly into the airways, providing rapid onset of action and minimal systemic absorption.

It's important to note that intratracheal anesthesia should only be performed by trained medical professionals, as there are potential risks associated with this procedure, including damage to the airway, respiratory compromise, and other complications.

... is a chiral molecule that is used as a racemic mixture. Halothane was discovered in 1951. It was approved for medical ... Halothane is believed to make a negligible contribution to global warming. Halothane is an ozone depleting substance with an ... Since the risk of halothane hepatitis in children was substantially lower than in adults, halothane continued to be used in ... Halothane, sold under the brand name Fluothane among others, is a general anaesthetic. It can be used to induce or maintain ...
The oxidation of these molecules by CYP2E1 can produce harmful substances such as trifluoroacetic acid chloride from halothane ... Ray DC, Drummond GB (Jul 1991). "Halothane hepatitis". British Journal of Anaesthesia. 67 (1): 84-99. doi:10.1093/bja/67.1.84. ... In doing so, CYP2E1 bioactivates a variety of common anesthetics, including paracetamol (acetaminophen), halothane, enflurane, ...
Jaundice after halothane. British Medical Journal, 1:220-221, 27 April 1974 Inman WHW. Monitoring for Drug Safety. J B ... halothane and jaundice, and phenylbutazone and blood dyscrasias. In total Inman published around 100 papers on drug monitoring ...
Halothane: an inhalational anesthetic. Isoflurane: an inhalational anesthetic. Ketamine: a dissociative hallucinogen with ...
Kimless-Garber, D.B.; Wolfson, M.R.; Carlsson, C.; Shaffer, T.H. (May 1997). "Halothane administration during liquid ...
... s consisting of two constituents are called binary azeotropes such as diethyl ether (33%) / halothane (66%) a mixture ... G.A.; Bashein, Professor G. (2004). "The halothane/ether azeotrope - A reconsideration". Update in Anaesthesia. 18. Archived ...
At ~1 MAC halothane, reported minor changes in tubulin protein expression (~1.3-fold) in primary cortical neurons after ... Further proteomic study reports 0.5 mM [14C]halothane binding to tubulin monomers alongside three dozens of other proteins. In ... Pan, Jonathan Z.; Xi, Jin; Tobias, John W.; Eckenhoff, Maryellen F.; Eckenhoff, Roderic G. (2007). "Halothane binding proteome ... At high concentrations (~5 MAC) the anesthetic gas halothane causes reversible depolymerization of microtubules. This cannot be ...
Part II: Halothane effects on structure and dynamics". Biophysical Journal. 94 (11): 4464-4472. Bibcode:2008BpJ....94.4464C. ... Hemmings Jr, H. C.; Adamo, A. I. (1994). "Effects of halothane and propofol on purified brain protein kinase C activation". ... enflurane and halothane. The enhancement of GABAA receptor activity is unlikely to be the only mechanism to account for the ...
Humans that have been anesthetised by halothane, convert some in the body to 2-chloro-1,1-difluoroethene and then exhale it. ... "Volatile Metabolites and Decomposition Products of Halothane In Man". Anesthesiology. 50 (1): 2-8. doi:10.1097/00000542- ...
TFA is a metabolic breakdown product of the volatile anaesthetic agent halothane. It is thought to be responsible for halothane ... "Halothane", LiverTox: Clinical and Research Information on Drug-Induced Liver Injury, Bethesda (MD): National Institute of ...
Pig farmers use halothane cones in swine yards to expose piglets to halothane. Those that die were MH-susceptible, thus saving ... Intramuscular injection of halothane 6 vol% has been shown to result in higher than normal increases in local pCO 2 among ... Caffeine, halothane, and other triggering agents act by drastically increasing the affinity of the A-site for Ca2+ and ... The standard procedure is the "caffeine-halothane contracture test", CHCT. A muscle biopsy is carried out at an approved ...
This channel has also been found to be involved in the action of anaesthetics such as chloroform, halothane and propofol. TRPC5 ... "Modulation of TRPC5 cation channels by halothane, chloroform and propofol". Br. J. Pharmacol. 153 (7): 1505-12. doi:10.1038/sj. ...
Halothane gas was the most common anaesthetic for many years. There had been deaths with halothane and liver damage, and was ... Work was carried out at Widnes Laboratory from 1951 to 1956 which led to the discovery of halothane in 1955. ...
In particular, the Halothane gene, HAL, induces PSS in swine. It is a single point mutation in this gene that causes abnormal ... The first gene discovered was named the Halothane gene, Hal, because researchers noticed that pigs with this specific genotype ... developed PSE meat after being anesthetized with the halothane drug. However, the Hal gene is only responsible for about 25-35 ...
The introduction of halothane into clinical practice: the Oxford experience. Anaesth. Intensive Care. 2006 Jun;34 Suppl 1:27-32 ... Suckling first investigated halothane's anaesthetic action by experimenting on mealworms and houseflies, and then forwarded it ... Charles Walter Suckling CBE FRS (24 July 1920 - 31 October 2013) was a British chemist who first synthesised halothane, a ...
Older, less popular, volatile anaesthetics, include halothane, enflurane, and methoxyflurane. Researchers are also actively ...
The introduction of halothane in 1956 greatly diminished the use of TCE as a general anesthetic. TCE was still used as an ... It was used with halothane in the Tri-service field anaesthetic apparatus used by the UK armed forces under field conditions. ... Trichloroethylene has been used in the production of halothane, another anaesthetic. It has also been used as a dry cleaning ... TCE lost popularity in North America and Europe to more potent anesthetics such as halothane by the 1960s. The symptoms of ...
In 1956 halothane was introduced which had the significant advantage of not being flammable. This reduced the risk of operating ... Halothane remains in common place throughout much of the developing world. Many new intravenous and inhalational anesthetics ... In the sixties the halogenated ethers superseded Halothane due to the rare, but significant side effects of cardiac arrhythmias ...
Compared with halothane, methoxyflurane produces dose-dependent abnormalities in kidney function. The authors showed that ...
Lanier WL, Milde JH, Michenfelder JD (Dec 1985). "The cerebral effects of pancuronium and atracurium in halothane-anesthetized ... increases the minimum alveolar concentration of halothane in rabbits". Anesthesiology. 63 (6): 584-589. doi:10.1097/00000542- ...
It is an anesthetic with effects related to isoflurane and halothane. Chlorobutanol is toxic to the liver, a skin irritant and ...
There were rare reports involving adults with symptoms similar to halothane hepatotoxicity. Sevoflurane is the preferred agent ... Together with desflurane, sevoflurane is replacing isoflurane and halothane in modern anesthesia practice. It is often ...
Merkel, Giles; Eger, Edmond I. (1963-05-01). "A Comparative Study of Halothane and Halopropane AnesthesiaIncluding Method for ... 1.17 Halothane - 0.75 Chloroform - 0.5 Methoxyflurane - 0.16 "Policy: Ban on Use of Ether". Laboratory Animal Science Center. ...
The compound can also be produced if halothane is oxidized using CYP2E1. This is also done with CYP2A6 instead of CPY2E1, but ...
The majority of inhaled anesthetics are heavily fluorinated; the prototype halothane is much more inert and potent than its ... Later compounds such as the fluorinated ethers sevoflurane and desflurane are better than halothane and are almost insoluble in ...
Halothane, the world's first synthetic inhalation general anaesthetic gas, was discovered in 1951 at ICI's Widnes Laboratory by ... for metered-dose inhalers and the anaesthetic halothane. There is Ineos Chlor and Ineos Vinyls. BNFL and its subsidiary ...
"Influence of morphine sulfate on the halothane sparing effect of xylazine hydrochloride in horses". American Journal of ... "The pharmacokinetics of ketamine after a continuous infusion under halothane anaesthesia in horses". Journal of Veterinary ... the half-life of xylazine is approximately 66 minutes and the clearance is around 31 mL/kg/min when patients are halothane- ...
... in children during halothane anaesthesia". British Journal of Anaesthesia. 74 (1): 6-11. doi:10.1093/bja/74.1.6. PMID 7880708. ...
When used with halothane d-tubocurarine can cause a profound fall in blood pressure in some patients as both the drugs are ... Mashraqui, S. (October 1994). "Hypotension induced with d-tubocurarine and halothane for surgery of patent ductus arteriosus". ...
The anesthetic halothane (CF3CHBrCl) is 2-bromo-2-chloro-1,1,1-trifluoroethane. Alcohols (R-OH) take the suffix "-ol" with a ...
Halothane is a chiral molecule that is used as a racemic mixture. Halothane was discovered in 1951. It was approved for medical ... Halothane is believed to make a negligible contribution to global warming. Halothane is an ozone depleting substance with an ... Since the risk of halothane hepatitis in children was substantially lower than in adults, halothane continued to be used in ... Halothane, sold under the brand name Fluothane among others, is a general anaesthetic. It can be used to induce or maintain ...
Other names: Ethane, 2-bromo-2-chloro-1,1,1-trifluoro-; Anestan; Fluktan; Fluorotane; Fluorothane; Fluothane; Ftorotan; Ftuorotan; Halan; Halotan; Halotano; Halothan; Halsan; Narcotan; Narcotane; Narkotan; CF3CHClBr; 1,1,1-Trifluoro-2-bromo-2-chloroethane; 2-Bromo-2-chloro-1,1,1-trifluoroethane; 1,1,1-Trifluoro-2-chloro-2-bromoethane; FREON 123B1; 1-Bromo-1-chloro-2,2,2-trifluoroethane; Bromochlorotrifluoroethane; 2,2,2-Trifluoro-1-chloro-1-bromoethane; Chalothane; Ethane, 1-bromo-1-chloro-2,2,2-trifluoro-; Narcotann ne-spofa; Rhodialothan; (.+/-.))-Halothane; Alotano; NSC 143490 ...
The National Halothane Study, a retrospective analysis, reviewed the incidence and mortality rates of postoperative hepatic ... Halothane and other halogenated inhalational anesthetic agents, such as enflurane, isoflurane, sevoflurane, and desflurane, are ... Type I (mild) halothane hepatotoxicity occurs within hours of halothane exposure. It does not occur after other agents. Type I ... Halothane hepatotoxicity is more likely to occur in lower resource settings where halothane continues to be used. ...
Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. ( ... Halothane: A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no ... Halothane (Fluothane). Subscribe to New Research on Halothane A nonflammable, halogenated, hydrocarbon anesthetic that provides ... halothane. ". 12/01/1983 - "The results of these studies do not support a use of halothane-induced aggregation of platelets to ...
Halothane and propofol appear to cause much less emergence agitation. The aim of this study was to compare the incidence of ... The mean dose during maintenance of anesthesia with propofol was 9.0 mg/kg/h or halothane 1.5-2% and fentanyl at a total dose ... emergence agitation in children receiving either propofol or halothane anesthesia for a variety of surgical treatments using ... of propofol maintenance anesthesia is associated with a significantly higher incidence of emergence agitation than halothane ...
A344 HALOTHANE, ISOFLURANE AND Ca2+ TRANSIENTS IN CULTURED VASCULAR SMOOTH MUSCLE CELLS P laizzo, Ph.D; P laizzo, Ph.D ... P laizzo, J C Sill, R Olsen, G Powis, R A Van Dyke; A344 HALOTHANE, ISOFLURANE AND Ca2+ TRANSIENTS IN CULTURED VASCULAR SMOOTH ... Role of Intracellular Ca 2+ Stores in the Inhibitory Effect of Halothane on Airway Smooth Muscle Contraction Anesthesiology ( ...
Selective bond breaking of halothane induced by electron transfer in potassium collisions. / Lozano, Ana Isabel; Maioli, ... Selective bond breaking of halothane induced by electron transfer in potassium collisions. Physical Chemistry Chemical Physics ... Selective bond breaking of halothane induced by electron transfer in potassium collisions. In: Physical Chemistry Chemical ... Dive into the research topics of Selective bond breaking of halothane induced by electron transfer in potassium collisions. ...
DATEX OHMEDA TEC-5 HALOTHANE. The GE Datex Ohmeda TEC 5 Halothane anesthesia vaporizers are temperature, flow, and pressure ... Be the first to review "DATEX OHMEDA TEC-5 HALOTHANE" Cancel reply. Your Rating. Rate…. Perfect. Good. Average. Not that bad. ...
"Halothane Hepatitis" B. Walton, M.B., B.S., F.F.A.R.C.S.; B. Walton, M.B., B.S., F.F.A.R.C.S. ... Suspected Isoflurane Hepatitis in an Obese Patient with a History of Halothane Hepatitis Anesthesiology (December 1995) ... Cardiac and Regional Hemodynamic Interactions between Halothane and Nitric Oxide Synthase Activity in Dogs Anesthesiology (July ... Hepatic Effects of Repeated Halothane Anesthetics in the Hypoxic Rat Model Anesthesiology (September 1987) ...
The Metabolic Effects of Halothane on Mammalian Hepatoma Cells in Vitro: I. Inhibition of Cell Replication Stephen H. Jackson, ... Stephen H. Jackson; The Metabolic Effects of Halothane on Mammalian Hepatoma Cells in Vitro: I. Inhibition of Cell Replication ...
Goldmans Halothane Vaporizer offered by Oxytech Engineers, Kolkata, West Bengal. ... We are prime manufacturers of Goldman halothane vaporizer which is primarily used in hospitals due to their critical and very ...
Although these investigations disclosed no evidence of adverse effects, reports of liver dysfunction after halothane ... Halothane (2-bromo-2-chloro-1, 1, 1-trifluoro-ethane) is the most popular inhalation agent in todays anesthetic practice. Its ... Halothane (2-bromo-2-chloro-1, 1, 1-trifluoro-ethane) is the most popular inhalation agent in todays anesthetic practice. Its ... Although these investigations disclosed no evidence of adverse effects, reports of liver dysfunction after halothane ...
View products detecting gaseous Halothane. Tiger Handheld VOC Gas Detector. The Tiger handheld VOC gas detector is a ... View products detecting gaseous Halothane. Tiger Handheld VOC Gas Detector. The Tiger handheld VOC gas detector is a ...
Comparison between halothane and sevoflurane for adult vital capacity induction. British Journal of Anaesthesia 79 (3) , pp. ... After the randomization code was revealed, the adverse events were found to be in the halothane group. Although the sample size ... We have examined the differences in ventilatory characteristics between halothane and sevoflurane when used for adult vital ...
How to calculate what mass of halothane is inspired in one minute given the partial pressure and temperature?. Ask Question ... If the anesthetic mixture is inspired at the rate of $\pu{100 mL/min}$, what mass of halothane, $\ce{CHCIBrCF3}$, molecular ... weight $M = \pu{197.4 g/mol}$, is inspired in one minute if the partial pressure of halothane is $\pu{7.6 torr}$ and the ...
Halothane *. 151-67-7. KH6550000. Halowax® [Tetrachloronaphthalene]. 1335-88-2. QK3700000. Halowax® [Trichloronaphthalene]. ...
Elevation of serum xanthine oxidase following halothane anesthesia in the rat. Sh Giler*, E. Ventura, E. Levy, I. Urca, O. ... N2 - Halothane anesthesia was found to be hepatotoxic in the rat, as demonstrated by a significant elevation of serum xanthine ... AB - Halothane anesthesia was found to be hepatotoxic in the rat, as demonstrated by a significant elevation of serum xanthine ... Giler S, Ventura E, Levy E, Urca I, Sperling O, de Vries A. Elevation of serum xanthine oxidase following halothane anesthesia ...
Halothane reduced the response to both types of stimulation in a dose-dependent fashion. At halothane concentrations greater ... Halothane reduced the response to both types of stimulation in a dose-dependent fashion. At halothane concentrations greater ... Halothane reduced the response to both types of stimulation in a dose-dependent fashion. At halothane concentrations greater ... Halothane reduced the response to both types of stimulation in a dose-dependent fashion. At halothane concentrations greater ...
Effects of halothane sensitivity on growth and body composition traits in pigs. Y. HOUIX, P. SELLIER and G. MONIN Without ... Influence of halothane sensitivity and ultimate pH on meat quality in three pig breeds Ann. Zootech. 37, 199-200 (1988). ... Meat quality in four pig breeds : relationships with halothane sensitivity and plasma creatine phosphokinase activity Ann. ...
... ... The kidney effects of halothane, enflurane and isoflurane were evaluated by using the ratio of urinary excretion of alanine ... Groups 1, 2 and 3 received halothane, enflurane and isoflurane respectively, Creatinine and AAP activities in urine spot tests ... The present study did not reveal any significant difference in the kidney effects of halothane, enflurane and isoflurane ...
Halothane. Only generic is available. Isoflurane. Forane Ketamine. Ketalar Lorazepam injection. Ativan ...
The aims of our study were to determine concentrations of wasted halothane in operating rooms and to investigate the effect of ... halothane pollution on liver functions of exposed personnel. The studied group included operating room personnel from the ... The aims of our study were to determine concentrations of wasted halothane in operating rooms and to investigate the effect of ... The results suggest that exposure to wasted halothane may be harmful to the livers of operating room personnel. ...
Effects of Halothane In healthy hamsters, halothane induced a marked dose-dependent negative inotropic effect, as shown by the ... Myocardial Effects of Halothane and Isoflurane in Hamsters with Hypertrophic Cardiomyopathy Benoit Vivien, MD; Benoit Vivien, ... but this is not true for halothane. [11] In contrast, Hattori et al. [12] showed that the effects of halothane and isoflurane ... which has been shown to occur to a lesser extent with isoflurane than with halothane; furthermore, halothane, but not ...
Dive into the research topics of Use of halothane as a model for investigating chemical-induced autoimmune hepatotoxicity. ... Use of halothane as a model for investigating chemical-induced autoimmune hepatotoxicity. ...
Detailed drug Information for Ritalin-SR. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
This medicine may cause some people to be agitated, irritable, or display other abnormal behaviors, such as feeling sad or hopeless, getting upset easily, or feeling nervous, restless, or hostile. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you or your caregiver notice any of these side effects, tell your doctor right away. This medicine may cause respiratory depression, a serious breathing problem that can be life-threatening, when used together with narcotic pain medicines. Check with your doctor right away if you have pale or blue lips, fingernails, or skin, difficult or troubled breathing, or irregular, fast or slow, or shallow breathing. Check with your doctor right away if you have a fever, rash, swollen, painful, or tender lymph glands in the neck, armpit, or groin, unusual bleeding or bruising, or yellow eyes or skin. These may be symptoms of a serious and life-threatening allergic reaction called drug reaction with eosinophilia ...
Detailed drug Information for Duo-Vil 2-25. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
Halothane / adverse effects * Humans * Isoflurane / adverse effects * Isoflurane / analogs & derivatives* * Methyl Ethers / ...
Drug-induced liver injury (DILI) is an injury of the liver that may occur when you take certain medicines.
  • Concern for hepatitis resulted in a dramatic reduction in the use of halothane for adults and it was replaced in the 1980s by enflurane and isoflurane. (wikipedia.org)
  • The kidney effects of halothane, enflurane and isoflurane were evaluated by using the ratio of urinary excretion of alanine aminopeptidase (AAP) to urine creatinine. (hacettepe.edu.tr)
  • Groups 1, 2 and 3 received halothane, enflurane and isoflurane respectively, Creatinine and AAP activities in urine spot tests, serum creatinine and BUN levels were determined preoperatively and on the first and second postoperative days. (hacettepe.edu.tr)
  • The present study did not reveal any significant difference in the kidney effects of halothane, enflurane and isoflurane through AAP/creatinine in spot urine values. (hacettepe.edu.tr)
  • The effects of halothane and isoflurane on myocardial contraction and relaxation in diseased myocardium are not completely understood. (silverchair.com)
  • However, the negative inotropic effects of halothane and isoflurane were not different for cardiomyopathic or healthy hamsters when their concentrations were corrected for minimum alveolar concentration (MAC) values in each strain. (silverchair.com)
  • Halothane and isoflurane induced no significant lusitropic effect under high load. (silverchair.com)
  • Halothane and isoflurane had greater negative inotropic effects in cardiomyopathic than in healthy hamsters. (silverchair.com)
  • 2. Inhalant anesthetics (e.g., halothane, isoflurane) can be used for euthanasia of rodents. (theodora.com)
  • We have examined the short-term effects of three volatile anaesthetics, halothane, isoflurane and desflurane, on mucociliary activity in the rabbit maxillary sinus in vivo. (lu.se)
  • Administration of 1.0 MAC of halothane, isoflurane or desflurane caused a temporary increase in mucociliary activity, with mean peak responses of 47.8 (SEM 13.0)%, 44.0 (9.6)% and 45.1 (23.7)% (n = 6), respectively. (lu.se)
  • The second peak at 3-5 min was less pronounced for halothane than for isoflurane or desflurane. (lu.se)
  • the inhalational anesthetic is most often halothane, but other anesthetics (eg, isoflurane , sevoflurane , desflurane ) may also be involved. (msdmanuals.com)
  • Currently, halothane is rarely used in economically developed nations due to the availability of newer and safer volatile anesthetics, such as enflurane and sevoflurane . (medscape.com)
  • We have examined the differences in ventilatory characteristics between halothane and sevoflurane when used for adult vital capacity induction of anaesthesia. (cardiff.ac.uk)
  • Differential effects of halothane and sevoflurane on hypoxia-induced intracellular calcium transients of neonatal rat carotid body type I cells. (ox.ac.uk)
  • BACKGROUND: The purpose of this study was to investigate the effects of halothane and sevoflurane on the magnitude of the increase in intracellular calcium with hypoxia in carotid body type I (glomus) cells. (ox.ac.uk)
  • We wished to ascertain if the effects of these agents in single cells paralleled their known effects on the human hypoxic ventilatory response, where halothane depresses this response more than does sevoflurane. (ox.ac.uk)
  • Halothane and sevoflurane were administered in concentrations ranging from 0.18 to 1.45 and 0.1 to 2 minimum alveolar concentration (MAC), respectively (rat values). (ox.ac.uk)
  • RESULTS: Halothane depressed the increase in intracellular calcium with hypoxia more than did sevoflurane (P=0.036). (ox.ac.uk)
  • Although halothane was depressive at all concentrations tested, sevoflurane depressed the calcium response only at 2 MAC. (ox.ac.uk)
  • Both agents also depressed the calcium response to elevated extracellular potassium-halothane more so than sevoflurane (P=0.004). (ox.ac.uk)
  • For single breath induction, what percentage Halothane or Sevoflurane? (studystack.com)
  • Since the risk of halothane hepatitis in children was substantially lower than in adults, halothane continued to be used in pediatrics in the 1990s as it was especially useful for inhalation induction of anesthesia. (wikipedia.org)
  • The aim of this study was to compare the incidence of emergence agitation in children receiving either propofol or halothane anesthesia for a variety of surgical treatments using the Pediatric Anesthesia Emergence Delirium (PAED) scale. (medscimonit.com)
  • The subjects were 83 premedicated children aged 1 to 6 years who underwent surgical procedures with propofol (group P, n=41) or with halothane (group H, n=42) anesthesia. (medscimonit.com)
  • The mean dose during maintenance of anesthesia with propofol was 9.0 mg/kg/h or halothane 1.5-2% and fentanyl at a total dose of 5 microg/kg administered during surgery. (medscimonit.com)
  • In children, the administration of propofol maintenance anesthesia is associated with a significantly higher incidence of emergence agitation than halothane maintenance anesthesia. (medscimonit.com)
  • The GE Datex Ohmeda TEC 5 Halothane anesthesia vaporizers are temperature, flow, and pressure compensated so that its output remains relatively constant despite cooling due to evaporation.Designed for out of circuit use in continuous flow techniques of inhalation anesthesia,The TEC 5 is designed to be used on Selectatec Series Mounted Manifolds.Our All Units Are Refurbished , Ready to Use and all units are checked with our Biomedical Engineer team. (med-equip.ca)
  • Halothane anesthesia was found to be hepatotoxic in the rat, as demonstrated by a significant elevation of serum xanthine oxidase (SXO) level. (tau.ac.il)
  • Chemically, halothane is an alkyl halide (not an ether like many other anesthetics). (wikipedia.org)
  • Halothane, sold under the brand name Fluothane among others, is a general anaesthetic. (wikipedia.org)
  • The resulting syndrome was referred to as halothane hepatitis, immunoallergic in origin, and is thought to result from the metabolism of halothane to trifluoroacetic acid via oxidative reactions in the liver. (wikipedia.org)
  • To examine possible mechanisms of action of halothane at clinically relevant concentrations the authors studied the effect of halothane on increases in pulmonary resistance (R(L)) produced by either vagus nerve stimulation (VNS, which caused neurally mediated constriction) or the inhalation of nebulized acetylcholine (ACh, which directly stimulated the smooth muscle cell) in nine mongrel dogs. (elsevierpure.com)
  • At halothane concentrations greater than or equal to 0.4 MAC, the VNS response was significantly less than the ACh response. (elsevierpure.com)
  • The authors conclude that in addition to neurally mediated effects, halothane at clinically used concentrations has significant direct effects on airway smooth muscle stimulated by ACh. (elsevierpure.com)
  • The aims of our study were to determine concentrations of wasted halothane in operating rooms and to investigate the effect of halothane pollution on liver functions of exposed personnel. (pjoes.com)
  • In rare cases, cirrhosis may develop following halothane hepatitis. (medscape.com)
  • However, the findings in halothane hepatitis are indistinguishable from those of fulminant viral hepatitis . (medscape.com)
  • Because halothane hepatitis is a diagnosis of exclusion, ruling out other causes is essential. (medscape.com)
  • We evaluated various dimensions of this replacement through a literature review to assess the incidence of halothane-induced hepatitis and costs of anaesthetics in the country. (who.int)
  • The results indicate that the incidence of halothane hepatitis in the Islamic Republic of Iran is very low and could mostly be avoided by strict adherence to guidelines. (who.int)
  • Anaesthesia has been influential in dif- Iran in 2006 when a number of experts thane-induced hepatitis, some profes- ferent fields of medical practice, espe- claimed that halothane should be sionals have insisted on the necessity cially in surgical procedures and efforts considered a major health threat [10]. (who.int)
  • Our product range includes a wide range of goldmans halothane vaporizer. (ipsmedicalproducts.com)
  • We are prime manufacturers of Goldman halothane vaporizer which is primarily used in hospitals due to their critical and very important requirement and performance. (ipsmedicalproducts.com)
  • Halothane vaporizer. (theodoregray.com)
  • In rare cases, repeated exposure to halothane in adults was noted to result in severe liver injury. (wikipedia.org)
  • Type I (mild) halothane hepatotoxicity occurs within hours of halothane exposure. (medscape.com)
  • Type II (fulminant) halothane hepatotoxicity usually occurs 5-7 days following exposure, although it can be delayed by up to 4 weeks. (medscape.com)
  • The results suggest that exposure to wasted halothane may be harmful to the livers of operating room personnel. (pjoes.com)
  • Halothane given with succinylcholine for induction anesthetic is associated with masseter spasm. (medscape.com)
  • Halothane (2-bromo-2-chloro-1, 1, 1-trifluoro-ethane) is the most popular inhalation agent in today's anesthetic practice. (vcu.edu)
  • Inhalation anesthetic molecules such as halothane cause these lipid regions to mix, potentially affecting the function of ion channel proteins found imbedded in the membrane. (nist.gov)
  • Halothane is the most effective inhalant anesthetic for euthanasia. (theodora.com)
  • It has been suggested that halothane inhibits contraction of airway smooth muscle in vivo mainly by reducing reflex activity in nerves innervating the muscle with only minimal direct effects on the muscle itself. (elsevierpure.com)
  • The National Halothane Study, a retrospective analysis, reviewed the incidence and mortality rates of postoperative hepatic necrosis from 1959-1962. (medscape.com)
  • Worker exposures to nitrous - oxide (10024972), halothane (151677), and ethrane (13838169) were surveyed on August 6 to 8, 1980 and February 9 to 12, 1981 at the Lincoln Medical and Mental Health Center (SIC-8062) in the Bronx, New York. (cdc.gov)
  • Exposures to nitrous - oxide , halothane, and ethrane ranged from 16 to 850, up to 14.4, and up to 2.4 parts per million (ppm), respectively. (cdc.gov)
  • Halothane and propofol appear to cause much less emergence agitation. (medscimonit.com)
  • Although these investigations disclosed no evidence of adverse effects, reports of liver dysfunction after halothane administration have appeared constantly in the literature. (vcu.edu)
  • of complete replacement of halothane have been ongoing over the years to Consequently, under supervision of with other inhalation agents such as find the most suitable anaesthetic agent. (who.int)
  • Halothane sensitises the heart to catecholamines, so it is liable to cause cardiac arrhythmia, occasionally fatal, particularly if hypercapnia has been allowed to develop. (wikipedia.org)
  • Halothane is C 2 HBrClF 3 , basically a chlorofluorocarbon of the ozone-depleting variety. (theodoregray.com)
  • Torske KE, Dyson DH, Pettifer G. End tidal halothane concentration and postoperative analgesia requirements in dogs: a comparison between intravenous oxymorphone and epidural bupivacaine alone and in combination with oxymorphone. (scielo.br)
  • Serum autoantibodies may be present in 30-44% of patients with type II halothane hepatotoxicity. (medscape.com)
  • This is then reacted with bromine at 450 °C to produce halothane. (wikipedia.org)
  • Based on this study, the risk of fatal halothane hepatotoxicity was estimated to be 1 in 35,000. (medscape.com)
  • Halothane hepatotoxicity is more likely to occur in lower resource settings where halothane continues to be used. (medscape.com)
  • Halothane hepatotoxicity is a diagnosis of exclusion. (medscape.com)
  • Physical findings in type II halothane hepatotoxicity include delayed pyrexia (up to 75% of patients). (medscape.com)
  • Eosinophilia occurs in 8-32% of patients with type II halothane hepatotoxicity. (medscape.com)
  • No specific therapy is available for either fulminant hepatic necrosis or mild hepatotoxicity due to halothane. (medscape.com)
  • Two major types of hepatotoxicity are associated with halothane administration. (medscape.com)
  • After the randomization code was revealed, the adverse events were found to be in the halothane group. (cardiff.ac.uk)
  • Halothane changes the domain structure of a binary lipid membrane. (nist.gov)
  • Given this risk, halothane is not recommended for use in adults. (medscape.com)
  • Surgeons were exposed to an average concentration of 29.41 mg/m 3 , anesthesiologists to 34.60 mg/m 3 , instrumenting nurses to 28.62 mg/m 3 and anesthetists to 30.09 mg/m 3 of halothane. (pjoes.com)
  • We present novel experimental results of negative ion formation of halothane (C2HBrClF3) upon electron transfer from hyperthermal neutral potassium atoms (K°) in the collision energy range of 8-1000 eV. (unl.pt)
  • Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (curehunter.com)
  • Comprehensive cost-effectiveness studies are needed before a decision is made on complete replacement of halothane with other anaesthetics. (who.int)
  • citation needed] The commercial synthesis of halothane starts from trichloroethylene, which is reacted with hydrogen fluoride in the presence of antimony trichloride at 130 °C to form 2-chloro-1,1,1-trifluoroethane. (wikipedia.org)
  • Halothane induced a negative lusitropic effect under low load, which was more important in cardiomyopathic hamsters, suggesting a greater impairment in calcium uptake by the sarcoplasmic reticulum. (silverchair.com)
  • The frequency of bilateral VNS and the dose of nebulized ACh were adjusted to produce approximately equal increases in R(L). Halothane reduced the response to both types of stimulation in a dose-dependent fashion. (elsevierpure.com)
  • The second response was not significant for halothane. (lu.se)
  • A combination of atropine and CP-99 pretreatment abolished the mucociliary response to halothane. (lu.se)
  • About 20% of inhaled halothane is metabolized by the liver and these products are excreted in the urine. (wikipedia.org)