Genetic Markers: A phenotypically recognizable genetic trait which can be used to identify a genetic locus, a linkage group, or a recombination event.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Microsatellite Repeats: A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs).Chromosome Mapping: Any method used for determining the location of and relative distances between genes on a chromosome.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Genetic Linkage: The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME.Alleles: Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.Polymorphism, Single Nucleotide: A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.Polymorphism, Genetic: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.Genetic Variation: Genotypic differences observed among individuals in a population.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Models, Genetic: Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Gene Frequency: The proportion of one particular in the total of all ALLELES for one genetic locus in a breeding POPULATION.Haplotypes: The genetic constitution of individuals with respect to one member of a pair of allelic genes, or sets of genes that are closely linked and tend to be inherited together such as those of the MAJOR HISTOCOMPATIBILITY COMPLEX.Genetics, Population: The discipline studying genetic composition of populations and effects of factors such as GENETIC SELECTION, population size, MUTATION, migration, and GENETIC DRIFT on the frequencies of various GENOTYPES and PHENOTYPES using a variety of GENETIC TECHNIQUES.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Polymorphism, Restriction Fragment Length: Variation occurring within a species in the presence or length of DNA fragment generated by a specific endonuclease at a specific site in the genome. Such variations are generated by mutations that create or abolish recognition sites for these enzymes or change the length of the fragment.Quantitative Trait Loci: Genetic loci associated with a QUANTITATIVE TRAIT.Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.Crosses, Genetic: Deliberate breeding of two different individuals that results in offspring that carry part of the genetic material of each parent. The parent organisms must be genetically compatible and may be from different varieties or closely related species.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Linkage Disequilibrium: Nonrandom association of linked genes. This is the tendency of the alleles of two separate but already linked loci to be found together more frequently than would be expected by chance alone.Recombination, Genetic: Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.Pedigree: The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.Physical Chromosome Mapping: Mapping of the linear order of genes on a chromosome with units indicating their distances by using methods other than genetic recombination. These methods include nucleotide sequencing, overlapping deletions in polytene chromosomes, and electron micrography of heteroduplex DNA. (From King & Stansfield, A Dictionary of Genetics, 5th ed)Genome-Wide Association Study: An analysis comparing the allele frequencies of all available (or a whole GENOME representative set of) polymorphic markers in unrelated patients with a specific symptom or disease condition, and those of healthy controls to identify markers associated with a specific disease or condition.DNA Primers: Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.HLA-B15 Antigen: A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*15 allele family.Expressed Sequence Tags: Partial cDNA (DNA, COMPLEMENTARY) sequences that are unique to the cDNAs from which they were derived.Quantitative Trait, Heritable: A characteristic showing quantitative inheritance such as SKIN PIGMENTATION in humans. (From A Dictionary of Genetics, 4th ed)DNA, Mitochondrial: Double-stranded DNA of MITOCHONDRIA. In eukaryotes, the mitochondrial GENOME is circular and codes for ribosomal RNAs, transfer RNAs, and about 10 proteins.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.DNA, Bacterial: Deoxyribonucleic acid that makes up the genetic material of bacteria.Resedaceae: A plant family of the order Capparales, subclass Dilleniidae, class Magnoliopsida. It is a small family of herbs and shrubs. Some produce GLUCOSINOLATES.Paternity: Establishing the father relationship of a man and a child.Breeding: The production of offspring by selective mating or HYBRIDIZATION, GENETIC in animals or plants.Hybridization, Genetic: The genetic process of crossbreeding between genetically dissimilar parents to produce a hybrid.Genetic Loci: Specific regions that are mapped within a GENOME. Genetic loci are usually identified with a shorthand notation that indicates the chromosome number and the position of a specific band along the P or Q arm of the chromosome where they are found. For example the locus 6p21 is found within band 21 of the P-arm of CHROMOSOME 6. Many well known genetic loci are also known by common names that are associated with a genetic function or HEREDITARY DISEASE.Water Pollution: Contamination of bodies of water (such as LAKES; RIVERS; SEAS; and GROUNDWATER.)Genome, Plant: The genetic complement of a plant (PLANTS) as represented in its DNA.Lod Score: The total relative probability, expressed on a logarithmic scale, that a linkage relationship exists among selected loci. Lod is an acronym for "logarithmic odds."DNA, Plant: Deoxyribonucleic acid that makes up the genetic material of plants.Heterozygote: An individual having different alleles at one or more loci regarding a specific character.Amplified Fragment Length Polymorphism Analysis: The detection of RESTRICTION FRAGMENT LENGTH POLYMORPHISMS by selective PCR amplification of restriction fragments derived from genomic DNA followed by electrophoretic analysis of the amplified restriction fragments.Inbreeding: The mating of plants or non-human animals which are closely related genetically.Geography: The science dealing with the earth and its life, especially the description of land, sea, and air and the distribution of plant and animal life, including humanity and human industries with reference to the mutual relations of these elements. (From Webster, 3d ed)Dinucleotide Repeats: The most common of the microsatellite tandem repeats (MICROSATELLITE REPEATS) dispersed in the euchromatic arms of chromosomes. They consist of two nucleotides repeated in tandem; guanine and thymine, (GT)n, is the most frequently seen.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Phylogeography: A field of study concerned with the principles and processes governing the geographic distributions of genealogical lineages, especially those within and among closely related species. (Avise, J.C., Phylogeography: The History and Formation of Species. Harvard University Press, 2000)Likelihood Functions: Functions constructed from a statistical model and a set of observed data which give the probability of that data for various values of the unknown model parameters. Those parameter values that maximize the probability are the maximum likelihood estimates of the parameters.Bayes Theorem: A theorem in probability theory named for Thomas Bayes (1702-1761). In epidemiology, it is used to obtain the probability of disease in a group of people with some characteristic on the basis of the overall rate of that disease and of the likelihood of that characteristic in healthy and diseased individuals. The most familiar application is in clinical decision analysis where it is used for estimating the probability of a particular diagnosis given the appearance of some symptoms or test result.Random Amplified Polymorphic DNA Technique: Technique that utilizes low-stringency polymerase chain reaction (PCR) amplification with single primers of arbitrary sequence to generate strain-specific arrays of anonymous DNA fragments. RAPD technique may be used to determine taxonomic identity, assess kinship relationships, analyze mixed genome samples, and create specific probes.Gene Flow: The change in gene frequency in a population due to migration of gametes or individuals (ANIMAL MIGRATION) across population barriers. In contrast, in GENETIC DRIFT the cause of gene frequency changes are not a result of population or gamete movement.Chromosomes, Artificial, Bacterial: DNA constructs that are composed of, at least, a REPLICATION ORIGIN, for successful replication, propagation to and maintenance as an extra chromosome in bacteria. In addition, they can carry large amounts (about 200 kilobases) of other sequence for a variety of bioengineering purposes.Minisatellite Repeats: Tandem arrays of moderately repetitive, short (10-60 bases) DNA sequences which are found dispersed throughout the GENOME, at the ends of chromosomes (TELOMERES), and clustered near telomeres. Their degree of repetition is two to several hundred at each locus. Loci number in the thousands but each locus shows a distinctive repeat unit.Sequence Tagged Sites: Short tracts of DNA sequence that are used as landmarks in GENOME mapping. In most instances, 200 to 500 base pairs of sequence define a Sequence Tagged Site (STS) that is operationally unique in the human genome (i.e., can be specifically detected by the polymerase chain reaction in the presence of all other genomic sequences). The overwhelming advantage of STSs over mapping landmarks defined in other ways is that the means of testing for the presence of a particular STS can be completely described as information in a database.Contig Mapping: Overlapping of cloned or sequenced DNA to construct a continuous region of a gene, chromosome or genome.Tandem Repeat Sequences: Copies of DNA sequences which lie adjacent to each other in the same orientation (direct tandem repeats) or in the opposite direction to each other (INVERTED TANDEM REPEATS).Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Transformation, Genetic: Change brought about to an organisms genetic composition by unidirectional transfer (TRANSFECTION; TRANSDUCTION, GENETIC; CONJUGATION, GENETIC, etc.) and incorporation of foreign DNA into prokaryotic or eukaryotic cells by recombination of part or all of that DNA into the cell's genome.Cluster Analysis: A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.Genome: The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.Blood Group Antigens: Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.Genome, Human: The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Models, Statistical: Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.Genetic Diseases, Inborn: Diseases that are caused by genetic mutations present during embryo or fetal development, although they may be observed later in life. The mutations may be inherited from a parent's genome or they may be acquired in utero.Wolves: Any of several large carnivorous mammals of the family CANIDAE that usually hunt in packs.Chromosomes, Bacterial: Structures within the nucleus of bacterial cells consisting of or containing DNA, which carry genetic information essential to the cell.Chromosomes, Plant: Complex nucleoprotein structures which contain the genomic DNA and are part of the CELL NUCLEUS of PLANTS.Genes, Plant: The functional hereditary units of PLANTS.Genetic Association Studies: The analysis of a sequence such as a region of a chromosome, a haplotype, a gene, or an allele for its involvement in controlling the phenotype of a specific trait, metabolic pathway, or disease.Genes, Dominant: Genes that influence the PHENOTYPE both in the homozygous and the heterozygous state.Computer Simulation: Computer-based representation of physical systems and phenomena such as chemical processes.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Genotyping Techniques: Methods used to determine individuals' specific ALLELES or SNPS (single nucleotide polymorphisms).Heterozygote Detection: Identification of genetic carriers for a given trait.Vaccines, Marker: Vaccines used in conjunction with diagnostic tests to differentiate vaccinated animals from carrier animals. Marker vaccines can be either a subunit or a gene-deleted vaccine.Immunoglobulin Gm Allotypes: Allelic variants of the gamma-immunoglobulin heavy chain (IMMUNOGLOBULIN GAMMA-CHAINS) encoded by ALLELES of IMMUNOGLOBULIN HEAVY CHAIN GENES.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)DNA Fingerprinting: A technique for identifying individuals of a species that is based on the uniqueness of their DNA sequence. Uniqueness is determined by identifying which combination of allelic variations occur in the individual at a statistically relevant number of different loci. In forensic studies, RESTRICTION FRAGMENT LENGTH POLYMORPHISM of multiple, highly polymorphic VNTR LOCI or MICROSATELLITE REPEAT loci are analyzed. The number of loci used for the profile depends on the ALLELE FREQUENCY in the population.Evolution, Molecular: The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.Software: Sequential operating programs and data which instruct the functioning of a digital computer.INDEL Mutation: A mutation named with the blend of insertion and deletion. It refers to a length difference between two ALLELES where it is unknowable if the difference was originally caused by a SEQUENCE INSERTION or by a SEQUENCE DELETION. If the number of nucleotides in the insertion/deletion is not divisible by three, and it occurs in a protein coding region, it is also a FRAMESHIFT MUTATION.Genes: A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.Genetic Testing: Detection of a MUTATION; GENOTYPE; KARYOTYPE; or specific ALLELES associated with genetic traits, heritable diseases, or predisposition to a disease, or that may lead to the disease in descendants. It includes prenatal genetic testing.Bacteroidetes: A phylum of bacteria comprised of three classes: Bacteroides, Flavobacteria, and Sphingobacteria.Genomics: The systematic study of the complete DNA sequences (GENOME) of organisms.DNA, Protozoan: Deoxyribonucleic acid that makes up the genetic material of protozoa.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Molecular Epidemiology: The application of molecular biology to the answering of epidemiological questions. The examination of patterns of changes in DNA to implicate particular carcinogens and the use of molecular markers to predict which individuals are at highest risk for a disease are common examples.Selection, Genetic: Differential and non-random reproduction of different genotypes, operating to alter the gene frequencies within a population.HLA Antigens: Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Homozygote: An individual in which both alleles at a given locus are identical.Immunoglobulin Allotypes: Allelic variants of the immunoglobulin light chains (IMMUNOGLOBULIN LIGHT CHAINS) or heavy chains (IMMUNOGLOBULIN HEAVY CHAINS) encoded by ALLELES of IMMUNOGLOBULIN GENES.Digitalis: A genus of toxic herbaceous Eurasian plants of the Plantaginaceae which yield cardiotonic DIGITALIS GLYCOSIDES. The most useful species are Digitalis lanata and D. purpurea.DNA Transposable Elements: Discrete segments of DNA which can excise and reintegrate to another site in the genome. Most are inactive, i.e., have not been found to exist outside the integrated state. DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Repetitive Sequences, Nucleic Acid: Sequences of DNA or RNA that occur in multiple copies. There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. Variations may be direct repeats, those occurring in the same direction, or inverted repeats, those opposite to each other in direction. TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted (INVERTED REPEAT SEQUENCES).Genetics: The branch of science concerned with the means and consequences of transmission and generation of the components of biological inheritance. (Stedman, 26th ed)Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Hybrid Cells: Any cell, other than a ZYGOTE, that contains elements (such as NUCLEI and CYTOPLASM) from two or more different cells, usually produced by artificial CELL FUSION.Pharmacogenetics: A branch of genetics which deals with the genetic variability in individual responses to drugs and drug metabolism (BIOTRANSFORMATION).DNA, Satellite: Highly repetitive DNA sequences found in HETEROCHROMATIN, mainly near centromeres. They are composed of simple sequences (very short) (see MINISATELLITE REPEATS) repeated in tandem many times to form large blocks of sequence. Additionally, following the accumulation of mutations, these blocks of repeats have been repeated in tandem themselves. The degree of repetition is on the order of 1000 to 10 million at each locus. Loci are few, usually one or two per chromosome. They were called satellites since in density gradients, they often sediment as distinct, satellite bands separate from the bulk of genomic DNA owing to a distinct BASE COMPOSITION.European Continental Ancestry Group: Individuals whose ancestral origins are in the continent of Europe.Karyotyping: Mapping of the KARYOTYPE of a cell.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Oncorhynchus: A genus of the family SALMONIDAE (salmons and trouts). They are named for their hooked (onco) nose (rhynchus). They are usually anadromous and occasionally inhabit freshwater. They can be found in North Pacific coastal areas from Japan to California and adjacent parts of the Arctic Ocean. Salmon and trout are popular game and food fish. Various species figure heavily in genetic, metabolism, and hormone research.Fiducial Markers: Materials used as reference points for imaging studies.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.DNA, Ribosomal: DNA sequences encoding RIBOSOMAL RNA and the segments of DNA separating the individual ribosomal RNA genes, referred to as RIBOSOMAL SPACER DNA.Genetic Drift: The fluctuation of the ALLELE FREQUENCY from one generation to the next.Rh-Hr Blood-Group System: Erythrocyte isoantigens of the Rh (Rhesus) blood group system, the most complex of all human blood groups. The major antigen Rh or D is the most common cause of erythroblastosis fetalis.Nuclear Family: A family composed of spouses and their children.Asian Continental Ancestry Group: Individuals whose ancestral origins are in the southeastern and eastern areas of the Asian continent.Blotting, Southern: A method (first developed by E.M. Southern) for detection of DNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.Gene Library: A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.Computational Biology: A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.Molecular Biology: A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.Chromosomes, Human, Pair 1: A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.Chromosomes: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Crossing Over, Genetic: The reciprocal exchange of segments at corresponding positions along pairs of homologous CHROMOSOMES by symmetrical breakage and crosswise rejoining forming cross-over sites (HOLLIDAY JUNCTIONS) that are resolved during CHROMOSOME SEGREGATION. Crossing-over typically occurs during MEIOSIS but it may also occur in the absence of meiosis, for example, with bacterial chromosomes, organelle chromosomes, or somatic cell nuclear chromosomes.Nucleic Acid Hybridization: Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)Nidovirales: An order comprising three families of eukaryotic viruses possessing linear, nonsegmented, positive sense RNA genomes. The families are CORONAVIRIDAE; ARTERIVIRIDAE; and RONIVIRIDAE.Hip Dysplasia, Canine: A hereditary disease of the hip joints in dogs. Signs of the disease may be evident any time after 4 weeks of age.Forensic Genetics: The application of genetic analyses and MOLECULAR DIAGNOSTIC TECHNIQUES to legal matters and crime analysis.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.DNA Mutational Analysis: Biochemical identification of mutational changes in a nucleotide sequence.DNA Restriction Enzymes: Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1.Restriction Mapping: Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.In Situ Hybridization, Fluorescence: A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.Gene Pool: The total genetic information possessed by the reproductive members of a POPULATION of sexually reproducing organisms.Diploidy: The chromosomal constitution of cells, in which each type of CHROMOSOME is represented twice. Symbol: 2N or 2X.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Feces: Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.Nuchal Cord: A complication of pregnancy in which the UMBILICAL CORD wraps around the fetal neck once or multiple times. In some cases, cord entanglement around fetal neck may not affect pregnancy outcome significantly. In others, the nuchal cord may lead to restricted fetal blood flow, oxygen transport, fetal development, fetal movement, and complicated delivery at birth.Genealogy and HeraldryGenes, Bacterial: The functional hereditary units of BACTERIA.Genome, Mitochondrial: The genetic complement of MITOCHONDRIA as represented in their DNA.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Animals, Domestic: Animals which have become adapted through breeding in captivity to a life intimately associated with humans. They include animals domesticated by humans to live and breed in a tame condition on farms or ranches for economic reasons, including LIVESTOCK (specifically CATTLE; SHEEP; HORSES; etc.), POULTRY; and those raised or kept for pleasure and companionship, e.g., PETS; or specifically DOGS; CATS; etc.Y Chromosome: The male sex chromosome, being the differential sex chromosome carried by half the male gametes and none of the female gametes in humans and in some other male-heterogametic species in which the homologue of the X chromosome has been retained.DNA, Ribosomal Spacer: The intergenic DNA segments that are between the ribosomal RNA genes (internal transcribed spacers) and between the tandemly repeated units of rDNA (external transcribed spacers and nontranscribed spacers).Azaguanine: One of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids.Drug Resistance: Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.Epistasis, Genetic: A form of gene interaction whereby the expression of one gene interferes with or masks the expression of a different gene or genes. Genes whose expression interferes with or masks the effects of other genes are said to be epistatic to the effected genes. Genes whose expression is affected (blocked or masked) are hypostatic to the interfering genes.Genetic Techniques: Chromosomal, biochemical, intracellular, and other methods used in the study of genetics.Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.Genes, Mitochondrial: Genes that are located on the MITOCHONDRIAL DNA. Mitochondrial inheritance is often referred to as maternal inheritance but should be differentiated from maternal inheritance that is transmitted chromosomally.Genetics, Microbial: A subdiscipline of genetics which deals with the genetic mechanisms and processes of microorganisms.Data Interpretation, Statistical: Application of statistical procedures to analyze specific observed or assumed facts from a particular study.Oryza sativa: Annual cereal grass of the family POACEAE and its edible starchy grain, rice, which is the staple food of roughly one-half of the world's population.Chimera: An individual that contains cell populations derived from different zygotes.Deoxyribonucleases, Type II Site-Specific: Enzyme systems containing a single subunit and requiring only magnesium for endonucleolytic activity. The corresponding modification methylases are separate enzymes. The systems recognize specific short DNA sequences and cleave either within, or at a short specific distance from, the recognition sequence to give specific double-stranded fragments with terminal 5'-phosphates. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 3.1.21.4.Plasmodium vivax: A protozoan parasite that causes vivax malaria (MALARIA, VIVAX). This species is found almost everywhere malaria is endemic and is the only one that has a range extending into the temperate regions.HLA-DQ Antigens: A group of the D-related HLA antigens found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases.China: A country spanning from central Asia to the Pacific Ocean.Bacterial Typing Techniques: Procedures for identifying types and strains of bacteria. The most frequently employed typing systems are BACTERIOPHAGE TYPING and SEROTYPING as well as bacteriocin typing and biotyping.Immunoglobulin Km Allotypes: Allelic variants of the kappa light chains (IMMUNOGLOBULIN KAPPA-CHAINS) encoded by ALLELES of IMMUNOGLOBULIN LIGHT CHAIN GENES.EuropeTunisia: A country in northern Africa between ALGERIA and LIBYA. Its capital is Tunis.HLA-DR Antigens: A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Immunogenetics: A subdiscipline of genetics which deals with the genetic basis of the immune response (IMMUNITY).Chromosomes, Human, Pair 8: A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.Reproduction: The total process by which organisms produce offspring. (Stedman, 25th ed)Chromosome Aberrations: Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.Genomic Library: A form of GENE LIBRARY containing the complete DNA sequences present in the genome of a given organism. It contrasts with a cDNA library which contains only sequences utilized in protein coding (lacking introns).Prostatic Neoplasms: Tumors or cancer of the PROSTATE.HLA-B Antigens: Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.Chromosomes, Human, Pair 16: A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Chromosomes, Human, Y: The human male sex chromosome, being the differential sex chromosome carried by half the male gametes and none of the female gametes in humans.Real-Time Polymerase Chain Reaction: Methods used for detecting the amplified DNA products from the polymerase chain reaction as they accumulate instead of at the end of the reaction.Breast Neoplasms: Tumors or cancer of the human BREAST.DNA Probes: Species- or subspecies-specific DNA (including COMPLEMENTARY DNA; conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32P and 125I and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.Chromosomes, Human: Very long DNA molecules and associated proteins, HISTONES, and non-histone chromosomal proteins (CHROMOSOMAL PROTEINS, NON-HISTONE). Normally 46 chromosomes, including two sex chromosomes are found in the nucleus of human cells. They carry the hereditary information of the individual.Mice, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.Chromosomes, Human, Pair 6: A specific pair GROUP C CHROMSOMES of the human chromosome classification.Plasmids: Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.Chromosomes, Human, Pair 7: A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.Disease Susceptibility: A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases.Probability: The study of chance processes or the relative frequency characterizing a chance process.Chromosomes, Human, Pair 11: A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.Forsythia: A plant genus of the family OLEACEAE. Members contain suspensaside.Transcriptome: The pattern of GENE EXPRESSION at the level of genetic transcription in a specific organism or under specific circumstances in specific cells.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Principal Component Analysis: Mathematical procedure that transforms a number of possibly correlated variables into a smaller number of uncorrelated variables called principal components.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Streptomycin: An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis.

*  Publication : USDA ARS
Title: Genetic variation at the waxy locus associated ... germplasm Author. Genetic variation at the waxy locus associated ... microsatellite marker. Two allele-types of the ex10 SNP,...
https://ars.usda.gov/research/publications/publication/?seqNo115=157575
*  The Biologistical Construction of Race: "Admixture" Technology and the New Genetic Medicine
and the New Genetic Medicine. The Biologistical ... and the New Genetic Medicine. DASH Home. FAS Scholarly ... and the New Genetic Medicine. Show simple item record....
https://dash.harvard.edu/handle/1/2943906?show=full
*  Gene Ontology Classifications
Genes. Genes Markers Query. Batch Query. Mouse Genome ... GO Browser. Genes Markers Query. Batch Query. Mouse Genome ... Batch Query. Genes Markers. Sequence Data. Gene Ontology Data....
http://informatics.jax.org/go/marker/MGI:1100492
*  Dach1 MGI Mouse Gene Detail - MGI:1277991 - dachshund 1 (Drosophila)
1 Drosophila. Genes Markers Query. Mouse Genome Browser. Gene ... Data Query. Genes Markers Query. Mouse Genome Browser. Mouse ... from 3 alleles in 4 genetic backgrounds 12 phenotype references....
http://informatics.jax.org/marker/MGI:1277991
*  XELECT LTD // Genetic solutions for aquaculture
XELECT LTD // Genetic solutions for aquaculture. HOME ABOUT ... SELECTION MARKERS ATLANTIC SALMON. NILE TILAPIA. RAINBOW ... SELECTION MARKERS ATLANTIC SALMON. NILE TILAPIA. RAINBOW ... a licence and genetic services agreement with Atlantic salmon...
http://xelect.co.uk/
*  .. Main menu .. Related Articles .. Breaking News .. The Scan .. Questioning the Worth of Array Dat
News Reimbursement. Genetic Research Gene Expression Research ... Epigenetics Research Proteomics Protein Research ... Diagnostics Biomarker Discovery Validation Drug Discovery...
https://genomeweb.com/archive/questioning-worth-array-data
*  Genetic Marker Linked to Aggressive Prostate Cancer ( nsive Cancer Center at Northwestern Uni...)
... Breaking Medicine Technology: Amgen To Present At The Barclays Biosimilars Symposium 2 Amgen To Present At The Barclays Biosimilars Symposium 3 Hyperalgesia Pipeline and 2015 Hyperalgesia Market Global Clinical Trials Reviewed in New Research Reports 2 Hyperalgesia Pipeline and 2015 Hyperalgesia Market Global Clinical Trials Reviewed in New Research Reports 3 Hyperalgesia Pipeline and 2015 Hyperalgesia Market Global Clinical Trials Reviewed in New Research Reports 4 Hyperalgesia Pipeline and 2015 Hyperalgesia Market Global Clinical Trials Reviewed in New Research Reports 5 Hyperalgesia Pipeline and 2015 Hyperalgesia Market Global Clinical Trials Reviewed in New Research Reports 6 Hyperalgesia Pipeline and 2015 Hyperalgesia Market Global Clinical Trials Reviewed in New Research Reports 7 Hyperalgesia Pipeline and 2015 Hyperalgesia Market Global Clinical Trials Reviewed in New Research Reports 8 Hyperalgesia Pipeline and 2015 Hyperalgesia Market Global Clinical Trials Reviewed in New Research Reports 9 Hype...
http://bio-medicine.org/medicine-news/Genetic-Marker-Linked-to-Aggressive-Prostate-Cancer-21549-2/
*  Adrb3 Targeted Allele Detail MGI Mouse (MGI:1860610)
Tools. Genes. Genes Markers Query. Batch Query. Mouse Genome ... GO Browser. Genes Markers Query. Batch Query. Strains / SNPs. SNP ... Batch Query. Genes Markers. Gene Ontology Data. Strains...
http://informatics.jax.org/allele/MGI:1860610
*  Diagnostic Pathology | Download References | Meta-analyses between 18 candidate genetic markers and
between candidate genetic markers and overweight obesity ... diagnostic pathology download references meta analyses between candidate genetic markers and overweight obesity diagnosticpathology org article bottom top biomed central journals gateways search diagnostic pathology biomed central for go advanced search home articles authors reviewers about this journal my diagnostic pathology diagnostic pathology volume viewing options abstract full text pdf mb additional files associated material pubmed record article metrics open badges readers comments related literature cited by google blog search other articles by authors on google scholar ...
http://diagnosticpathology.org/content/9/1/56/citation
*  Genelux Corporation Release Virus Engineered to Express Melanin Offers New Possibilities to Diagn
used as a visible marker during surgery, a mediator of laser- ... inserted the genetic information encoding melanin-producing ... for 3500 Dx Genetic Analyzers Genelux Corporation Announces...
http://biospace.com/news_story.aspx?StoryID=287572&full=1
*  Re: Out and about with granddaughter - FZ150: Panasonic Compact Camera Talk Forum: Digital Photograp
... hy Review. Reviews. Features. Sample Images. Videos. Cameras. Lenses. Forums. Forum index. Panasonic Compact Camera Talk Change forum Out and about with granddaughter - FZ150 Started Nov 13, 2012. Shop cameras lenses ▾. Forum Parent First Previous Next Next unread. Re: Out and about with granddaughter - FZ150 In reply to Don051348, Nov 13, 2012. Forum Parent First Previous Next Next unread. Posted by When Out and about with granddaughter - FZ150 New. Nov 13, 2012. Re: Out and about with granddaughter - FZ150 New. kkardster. Nov 13, 2012. Re: Out and about with granddaughter - FZ150 New. Nov 13, 2012. Re: Out and about with granddaughter - FZ150 New. Erik Ohlson. Nov 13, 2012. Re: Out and about with granddaughter - FZ150 New. Nov 13, 2012. Re: Out and about with granddaughter - FZ150 New. Nov 13, 2012. Re: Out and about with granddaughter - FZ150 New. John Miles. Nov 14, 2012. Re: Out and about with granddaughter - FZ150 New. Nov 15, 2012. Re: Out and about with granddaughter - FZ150 New. John Miles...
http://dpreview.com/forums/post/50282242
*  Genetic marker
A 'genetic marker' is a gene or DNA sequence with a known location on a chromosome that can be used to identify individuals or species. A genetic marker may be a short DNA sequence, such as a sequence surrounding a single base-pair change single nucleotide polymorphism, SNP, or a long one, like minisatellite s. Background Types Uses See also Other references References. For many years, gene mapping was limited in most organisms by traditional genetic markers which include genes that encode easily observable characteristics such as blood types or seed shapes. The insufficient number of these types of characteristics in several organisms limited the mapping efforts that could be done. RFLP or Restriction fragment length polymorphism SSLP or Simple sequence length polymorphism AFLP or Amplified fragment length polymorphism RAPD or Random amplification of polymorphic DNA VNTR or Variable number tandem repeat SSR Microsatellite polymorphism, or Simple sequence repeat SNP or Single nucleotide polymorphism STR or Sh...
https://en.wikipedia.org/wiki/Genetic_marker
*  New Genetic Marker to Fight Bird Flu Uncovered
... indiatimes logo. News Lifestyle Entertainment Videos Health Trending. indiatimes logo Menu Facebook. facebook USPS twitter facebook twitter search. X. Loading...... Load more. Home. News. India World Sports Weird. Lifestyle. Self Style Tech Who we are Travel Food. Entertainment. Bollywood Celebscoop Hollywood. Videos. Health. Healthy Living Recipes Inspire Tips & Tricks Buzz. Trending. Follow indiatimes facebook. twitter. Home. Technology. Science. New Genetic Marker to Fight Bird Flu By IndiaTimes December 27, 2013. facebook. twitter. mail. twitter. gplus. Indiatimes virality graph The graph shows how relevant this story is on social networks real-time. 2k Shares. Australian scientists have discovered a genetic marker that can accurately predict which patients will experience more severe disease in a new strain of avian influenza H7N9 currently found in China. MELBOURNE: Australian scientists have discovered a genetic marker that can accurately predict which patients will experience more severe disease ...
http://indiatimes.com/technology/science/new-genetic-marker-to-fight-bird-flu-uncovered-119565.html
*  Study Identifies Four New Genetic Markers For Severe Childhood Obesity | TIME.com
Study Identifies Four New Genetic Markers For Severe Childhood Obesity. TIME.com. Time.com. MY ACCOUNT SIGN IN SIGN OUT SUBSCRIBE Home. The TIME Vault. Subscribe Newsletters Feedback Privacy Policy Your California Privacy Rights Terms of Use Ad Choices. RSS TIME Apps TIME for Kids Advertising Reprints and Permissions Site Map Help Customer Service. 2015 Time Inc. All rights reserved. Subscribe. Sign In Subscribe. Study Identifies Four New Genetic Markers For Severe Childhood Obesity By Alexandra Sifferlin @acsifferlin April 12, 2013. Related Childhood Obesity: Scientists Find Two Gene Variants that Predispose Kids to Weight Gain. Childhood Obesity: Most U.S. Genetic mutations linked to childhood obesity The Independent Email. By comparing the genomes of 1,509 children in the UK with severe obesity to 5,380 similar children of normal weight, an international team of researchers first identified a series of 29 genetic changes that distinguished the heavier children. Some children will be obese because they have...
http://healthland.time.com/2013/04/12/study-finds-genetic-markers-for-severe-childhood-obesity/?xid=rss-topstories
*  Utah Mother Ready To Give Birth To Granddaughter, Volunteered As Gestational Surrogate For Daughter
... Vitality Under the Hood Innovation The Hill The Grapevine Weird Medicine Conditions. 8 Healthy Vegetarian Recipes That Are Perfect For Fall. 9 People Under 20 Who Have Contributed Amazing Things To Medicine. Healthcare, Policy & Governance. Weird Medicine. Healthy Living. Healthy Living. Utah Mother Ready To Give Birth To Granddaughter, Volunteered As Gestational Surrogate For Daughter. Justin Caba. When Lorena McKinnon, 32, began to accept that she may not be able to become pregnant, her mother Julia Navarro, 58, decided to do anything in her power to make her daughter’s dreams come true, even if that meant giving birth to her own granddaughter. Navarro is currently serving as gestational surrogate for her daughter Lorena and husband Micah McKinnon, and she says the unusual situation has actually brought the two closer. To qualify as a gestational surrogate, the American Society for Reproductive Medicine recommends a complete review of the surrogate's medical history and a physical examination including...
http://medicaldaily.com/utah-mother-ready-give-birth-granddaughter-volunteered-gestational-surrogate-daughter-266696
*  Gene mapping
'Gene mapping', describes the methods used to identify the locus of a gene and the distances between genes. Genes can be viewed as one special type of genetic markers in the construction of genome maps, and mapped the same way as any other markers. Genetic Mapping VS Physical Mapping Genetic Mapping. Genome sequencing. Use of Gene mapping Disease-association. Genetic Mapping VS Physical Mapping. There are two distinctive types of "Maps" used in the field of genome mapping: genetic maps and physical maps. While both maps are a collection of genetic markers and gene loci, genetic maps' distances are based on the genetic linkage information, while physical maps use actual physical distances usually measured in number of base pairs. Researchers begin a genetic map by collecting samples of blood or tissue from family members that carry a prominent disease or trait and family members that don't. Scientists then isolate DNA from the samples and closely examine it, looking for unique patterns in the DNA of the family...
https://en.wikipedia.org/wiki/Gene_mapping
*  Molecular marker
... A 'molecular marker' is a molecule contained within a sample taken from an organism biological markers or other matter. It can be used to reveal certain characteristics about the respective source. DNA, for example, is a molecular marker containing information about genetic disorder s, genealogy and the evolutionary history of life. Specific regions of the DNA genetic marker s are used to diagnose the autosomal recessive genetic disorder cystic fibrosis,. 1 taxonomic affinity phylogenetics and identity DNA Barcoding. Further, life forms are known to shed unique chemicals, including DNA, into the environment as evidence of their presence in a particular location. 2 Other biological markers, like proteins, are used in diagnostic tests for complex neurodegenerative disorders, such as Alzheimer's disease. 3 Non-biological molecular markers are also used, for example, in environmental studies. 4 Genetic Markers Application. Biochemical Markers Non-Biological Markers See also References External links. Genetic...
https://en.wikipedia.org/wiki/Molecular_marker
*  Catalog Of Gene Markers For Some Cancers Doubles In Size | KCUR
Catalog Of Gene Markers For Some Cancers Doubles In Size. KCUR. NPR News. Generation Listen KC. NPR News. Researchers have found new genetic markers that flag a person's susceptibility to the disease, as well as breast and ovarian cancer. The nearest hope is that the growing catalog of markers will allow researchers to fine-tune screening tests for these cancers. "It will take some time." The same is true for men with prostate cancer, who are currently bedeviled by the ambiguities of a screening test called PSA. Encouragingly, researchers are reporting 23 new genetic markers for prostate cancer. Rosalind Eeles of Britain's Institute of Cancer Research says men with many of these susceptibility markers in their genes have a nearly 50 percent chance of developing prostate cancer, versus about 10 percent for the average man. And if the biopsy shows cancer, that might argue for treatment rather than "watchful waiting." "If your risk is over 50 percent of getting prostate cancer in your lifetime, we don't know if ...
http://kcur.org/post/catalogue-gene-markers-some-cancers-doubles-size
*  ARS | Publication request: New DArT markers for oat provide enhanced map coverage and global germpla
Publication request: New DArT markers for oat provide enhanced map coverage and global germplasm characterization ARS : Research. Site Map. ARS Office of International Research Programs. Title: New DArT markers for oat provide enhanced map coverage and global germplasm characterization Authors. Submitted to: Biomed Central BMC Genomics Publication Type: Peer Reviewed Journal Publication Acceptance Date: January 21, 2009 Publication Date: January 21, 2009 Citation: Tinker, N.A., Kilian, A., Wright, C.P., Heller-Uszynska, K., Wenzl, P., Rines, H.W., Bjornstad, A., Howarth, C., Jannink, J., Anderson, J.M., Rossnagle, B.G., Stuthman, D.D., Sorrells, M.E., Jackson, E.W., Tuvesson, S., Kolb, F.L., Olsson, O., Federizzi, L.C., Carson, M.L., Ohm, H.W., Molnar, S.J., Scoles, G.J., Eckstein, P.E., Bonman, J.M., Ceplitis, A., Langdon, T. New DArT markers for oat provide enhanced map coverage and global germplasm characterization. This study was intended to develop, characterize, and apply a large set of oat genetic mark...
http://ars.usda.gov/research/publications/publications.htm?SEQ_NO_115=244137
*  I think she's Guinevere's gggg...granddaughter: Nikon DX SLR (D40-D90, D3000-D7100) Talk Forum: Digi
I think she's Guinevere's gggg...granddaughter: Nikon DX SLR D40-D90, D3000-D7100 Talk Forum: Digital Photography Review. Reviews. Sample Images. Videos. Cameras. Lenses. Forums. Challenges. Forum index. Nikon DX SLR D40-D90, D3000-D7100 Talk Change forum ***** Challenge # 63: Negative Space PART 2 ***** Started Nov 2, 2008. Shop cameras lenses ▾. Forum Parent First Previous Next Next unread. rhlpetrus. Forum Pro. Gear list. I think she's Guinevere's gggg...granddaughter In reply to jkjond, Nov 4, 2008. Have you seen the last incarnation of her in the movie King Arthur, a Woad warrior tough and good with arches. jkjond wrote: karinatwork wrote: Don't need a dartboard. I am not going. http://www.flickr.com/photos/rhlpedrosa/. rhlpetrus's gear list: rhlpetrus's gear list Leica D-Lux Typ 109. Nikon D7000. Nikon 1 V1. Nikon AF-S DX Nikkor 12-24mm f/4G ED-IF. Nikon AF Nikkor 35mm f/2D. Reply Reply with quote. Forum Parent First Previous Next Next unread. Posted by When ***** Challenge # 63: ...
http://dpreview.com/forums/post/29910293
*  ARS | Publication request: Co-dominant SCAR Markers for Detection of the Ty-3 and Ty-3a Loci from So
ARS. Publication request: Co-dominant SCAR Markers for Detection of the Ty-3 and Ty-3a Loci from Solanum chilense at 25 cM of Chromosome 6 of Tomato ARS : Research. ARS Home. About ARS. International Programs. Find an office at headquarters. Related Topics Programs and Projects. ARS National Programs. ARS Office of International Research Programs. ARS Office of International Research Programs Regional Contacts. Title: Co-dominant SCAR Markers for Detection of the Ty-3 and Ty-3a Loci from Solanum chilense at 25 cM of Chromosome 6 of Tomato Authors. Ji, Yuanfu - UN OF FL WIMAUMA. Salus, Melinda - UN OF WI MADISON. Van Betteray, Bram - NUNHEMS THE NETHERLANDS. Smeets, Josie - NUNHEMS THE NETHERLANDS. Jensen, Katie - UN OF WI MADISON. Martin, Christopher - UN OF WI MADISON. Scott, Jay - UN 0F FL WIMAUMA. Maxwell, Douglas - UN OF WI MADISON. Submitted to: Tomato Genetics Cooperative Publication Type: Research Notes Publication Acceptance Date: November 5, 2007 Publication Date: March 15, 2008 Citation: Ji, Y., Sal...
http://ars.usda.gov/research/publications/publications.htm?seq_no_115=215000
*  Research Summary : Sablefish Anoplopoma fimbria , aka black cod is an excellent species for commercial culture because of its high price and fast growth in culture. NOAA is developing the resources and techniques for intensive aquaculture of this species
http://faculty.washington.edu/sr320/?p=1046
*  ES selectable markers
... p jan hendrikx hendrikx at hema fgg eur nl wed mar est previous message es selectable markers next message mastoparan activation of g proteins and ndpk messages sorted by is it stupid to suggest lacz as a selectable marker it is easy to work with can be selected for using flow cytometry after viable staining and seems to have little effect on viability and growth rates it might also give you interesting expression patterns in the offspring which might give you nice applications greetings jan previous message es selectable markers next message mastoparan activation of g proteins and ndpk messages sorted by more information about the cellbiol mailing list...
http://bio.net/bionet/mm/cellbiol/1994-March/000344.html
*  IHC marker
... redirect immunohistochemistry...
https://en.wikipedia.org/wiki/IHC_marker
*  Study examines link between blood biomarkers and risk of Alzheimer's disease
... Home. Neuroscience. March 26, 2012 Study examines link between blood biomarkers and risk of Alzheimer's disease March 26, 2012 A meta-analysis of previously published studies found that the ratio of blood plasma amyloid- A peptides A 42:A 40 was significantly associated with development of Alzheimer disease and dementia, according to a report published Online First by Archives of Neurology. "Plasma levels of amyloid- A peptides have been a principal focus of the growing literature on blood-based biomarkers, but studies to date have varied in design, assay methods, and sample size, making it difficult to readily interpret the overall data," the authors write as background in the study. Alain Koyama, S.M., then of Harvard School of Public Health and Brigham and Women's Hospital, Boston, now with the University of California, San Francisco, and colleagues conducted a meta-analysis of 13 previously published studies to examine the association between plasma amyloid- and development of dementia, Alzheimer dis...
http://medicalxpress.com/news/2012-03-link-blood-biomarkers-alzheimer-disease.html
*  BSN: Biotech Science News
Cells 2. Cancer 3. Proteins. July 21, 2013 54th Annual Short Course on Medical and Experimental Mammalian Genetics Monday, July 29 Genetics of Infectious Diseases Steven M. September 24, 2009 Track 4: Bridging Silos in Biomarker Development : Seventh Annual Protein Biomarkers Towards a More Efficient Protein Biomarker Development Process Henry Rodriguez. September 29, 2008 Genomic Biomarkers Biomarkers for What. September 29, 2008 Metabolic Biomarkers Biomarkers for What. January 6, 2008 Structural Genomics and its Applications to Chemistry, Biology and Medicine Following Session is for Structural Biology J1 Membrane Protein Structure Alasdair C. December 1, 2007 47TH American Socieity of Cell Biology Membrane Dynamics Jennifer Lippincott-Schwartz. Seeing in The Dark: How Fluorescent Proteins Are Shaping Biology Jennifer Lippincott-Schwartz. September 17, 2007 Biomarker Discovery Summit: Bridging the Silos in Biomarker Discovery Validation Sep17-19 Third annual Genomic Biomarkers: BIOMARKER DATA ANALYSIS: Dec...
http://biotechsciencenews.com/OrgsBySpecialty/EventsByOrg/Proteomics_16871.html
*  Biomarker profiles in serum and saliva of experimental Sjögren's syndrome: associations with specif
... ic autoimmune manifestations. - PubMed - NCBI Warning: The NCBI web site requires JavaScript to function. NCBI. Resources. All Resources. BLAST Basic Local Alignment Search Tool. BLAST Basic Local Alignment Search Tool. Conserved Domain Search Service CD Search. Conserved Domain Search Service CD Search. PubMed. PubMed Central PMC. Search database All Databases Assembly BioProject BioSample BioSystems Books ClinVar Clone Conserved Domains dbGaP dbVar Epigenomics EST Gene Genome GEO DataSets GEO Profiles GSS GTR HomoloGene MedGen MeSH NCBI Web Site NLM Catalog Nucleotide OMIM PMC PopSet Probe Protein Protein Clusters PubChem BioAssay PubChem Compound PubChem Substance PubMed PubMed Health SNP SRA Structure Taxonomy ToolKit ToolKitAll ToolKitBook UniGene Search term. 1 selected item: 18289371 Format Summary Summary text Abstract Abstract text MEDLINE XML PMID List. Biomarker profiles in serum and saliva of experimental Sjögren's syndrome: associations with specific autoimmune manifestations. Factor analyses...
http://ncbi.nlm.nih.gov/pubmed/18289371
*  BSN: Biotech Science News
Cells 2. June 23, 2013 10th International Conference on Innate Immunity 10th International Conference on Innate Immunity Thomas A. February 26, 2011 Immunity in the Respiratory Tract: Challenges of the Lung Environment X6 Mucosal Biology X5. February 12, 2011 Cancer Control by Tumor Suppressors and Immune Effectors J8 Adaptive Immunity against Cancer. September 24, 2009 Track 4: Bridging Silos in Biomarker Development : Seventh Annual Protein Biomarkers Towards a More Efficient Protein Biomarker Development Process Henry Rodriguez. March 25, 2008 Preclinical Development Imaging as a Biomarker in Oncology Drug Trials and Improving Cancer Patient Care Gary J. December 1, 2007 47TH American Socieity of Cell Biology Membrane Dynamics Jennifer Lippincott-Schwartz. Seeing in The Dark: How Fluorescent Proteins Are Shaping Biology Jennifer Lippincott-Schwartz. October 17, 2007 Inaugral Nuclear Harmone Receptors Modulators: Targets for Drug Discovery Oct 17-18 NUCLEAR HORMONE RECEPTORS 14:10-18:50 John Cidlowski. Octo...
http://biotechsciencenews.com/OrgsBySpecialty/EventsByOrg/Cell Biology_16871.html
*  NOT-NS-13-020: Plan To Include All Parkinson's Disease Biomarkers Projects in the NINDS Parkinson's
... Disease Biomarkers Program PDBP. Plan To Include All Parkinson's Disease Biomarkers Projects in the NINDS Parkinson's Disease Biomarkers Program PDBP. Notice of Intent to Publish a Funding Opportunity Announcement for Biomarker Discovery through the Use of Data and Resources Developed by the NINDS Parkinson's Disease Biomarker Program PDBP U01. Key Dates Release Date: March 20, 2013 Issued by National Institute of Neurological Disorders and Stroke NINDS Purpose The creation of the NINDS Parkinson’s Disease Biomarkers Program PDBP has resulted in an opportunity for a common platform for exchanging data, protocols, and biospecimens for Parkinson’s Disease PD Biomarkers Research. Background The overall goal of the NINDS Parkinson’s Disease Biomarkers Program PDBP is to allow the rapid identification and development of potential biomarkers to improve the efficiency and outcome of Phase II or III clinical trials of neuroprotective agents in Parkinson’s Disease. In order to accomplish this goal, it is essentia...
http://grants.nih.gov/grants/guide/notice-files/NOT-NS-13-020.html
*  Biomarker Data Point to Target Patients for Transgene's Vaccine | BioWorld
Biomarker Data Point to Target Patients for Transgene s Vaccine. BioWorld. Jump to Navigation Login. Home. Login to Your Account Username: *. Password: *. Lost password. Register now. Help. Search this site:. explore. about conferences reports staff store about us. advertising BioWorld’s Partners in Focus. archives. editorial guidelines. faqs. publications BioWorld Today. BioWorld Asia. BioWorld Insight. BioWorld Market Reports. BioWorld Snapshots. store Reports. Conferences site map. start a risk-free subscription. Biomarker Data Point to Target Patients for Transgene s Vaccine. By Trista Morrison. Wednesday, September 17, 2008 Buy Reprint. To continue reading subscribe now to BioWorld Asia formerly International Learn More about BioWorld Asia formerly International Already a subscriber. Sign In or Buy now to activate your subscription. Login or register to post comments. explore ». about us. advertising BioWorld’s Partners in Focus. archives. editorial guidelines. faqs. publications BioWorld Today. Bio...
http://bioworld.com/content/biomarker-data-point-target-patients-transgenes-vaccine-0
*  Fecal water as a non-invasive biomarker in nutritional intervention: comparison of preparation meth
... ods and refinement of different endpoints - CentAUR. . University of Reading CentAUR: Central Archive at the University of Reading. Accessibility navigation Fecal water as a non-invasive biomarker in nutritional intervention: comparison of preparation methods and refinement of different endpoints. Tools Tools Tools. Wordle Link RDF+XML BibTeX RIOXX2 XML RDF+N-Triples JSON Dublin Core Atom Simple Metadata Refer METS HTML Citation with IDs HTML Citation ASCII Citation OpenURL ContextObject EndNote OpenURL ContextObject in Span MODS MPEG-21 DIDL EP3 XML Dublin Core Reference Manager RDF+N3. Klinder, A., Karlsson, P.C., Clune, Y., Hughes, R., Glei, M., Rafter, J.J., Rowland, I., Collins, J.K. and Pool-Zobel, B.L. 2007 Fecal water as a non-invasive biomarker in nutritional intervention: comparison of preparation methods and refinement of different endpoints. Nutrition and Cancer, 57 2. pp. 158-167. ISSN 0163-5581 Full text not archived in this repository. Official URL: http://www.tandf.co.uk/journals/authors/h...
http://centaur.reading.ac.uk/13248/
*  BSN: Biotech Science News
University of California, San Francisco. Proteomics: AstraZeneca Total Score People Score Events Score 26 21 19. April 30, 2010 Drug Story Development of a Portfolio of Therapeutic Antibodies for Oncology Combining Xenomouse and Display Technologies David Blakey. September 23, 2009 TRACK 4: Bridging Silos in Biomarker Development : Third Annual Biomarker Data Analysis New Biomarkers: Opportunities and Challenges Anastasia M. October 20, 2008 Protein Expression Europe Comments by Session Chairperson Stefan R. September 29, 2008 Genomic Biomarkers Personalized Healthcare – Where Are We Now. September 29, 2008 Metabolic Biomarkers Metabolomics/Proteomics: Tools for Biomarker Discovery within Safety Assessment Johan Lindberg. April 27, 2008 Phage Display of Antibodies and Peptides Development of a Portfolio of Therapeutic David Blakey. April 27, 2008 Phage Display of Antibodies and Peptides Development of a Portfolio of Therapeutic Antibodies for Oncology Combining Xenomouse and Display Technologies David Blakey....
http://biotechsciencenews.com/OrgsBySpecialty/EventsByOrg/Proteomics_19709.html
*  GEN News Highlights Related To | GEN
FDA Nominee Driven by "Data, Data, Data". Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. FDA Nominee Driven by "Data, Data, Data". Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. RNA Splicing Factor Linked with Causes of Breast Cancer. GEN News Highlights Related to Researchers Claim New Biomarker Detects Acute Kidney Injury Earlier than Serum Creatinine Researchers Identify Serum Biomarkers to Diagnose SLE and Differentiate Disease Severity and Activity Cancer Screening Approach Using HSV to Force Cells to Secrete Biomarker Developed LMTK3 Tyrosine Kinase Found to Impact Breast Cancer Survival and Drug Resistance Researchers Implicate Multiple Loci in Paget Disease of Bone Specific Adipose Stromal Cell Surface Receptor and Ligand Identified GNS and Bristol-Myers Squibb to Identify Immuno-Inflammation Biomarkers Investigators Identify CD8 T Cell Transcription Signature that Predicts Prognosis in Crohn's and Ulcerative Colitis Nuclear Heat-Shock Factor 1 May Represent Ind...
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Transitioning from Traditional Assay Formats to HTRF Technology. Wound Care Pipelines Expand with Bioactive Market. Jobs Report: Data, Business, and Regulatory ... Transitioning from Traditional Assay Formats to HTRF Technology. Wound Care Pipelines Expand with Bioactive Market. GEN News Highlights Related to Inostics Gains License from JHU for Development of Cancer-Related Mutation Testing Erytech, ExonHit Share €8.9M Initial OSEO Funding for Enzyme Depletion Anticancer Project Affymetrix, MGH Team Up to Develop Biomarker Tests Using QuantiGene ViewRNA Platform Biomarker Diagnostics Firm Astute Raises $40.4M in Series C Fundraising Companion Dx Negotiates License to Epigenomics’ Septin9 Blood Biomarker for CRC Test Merck Serono, Compugen Establish Biomarkers Firm Neviah Genomics VTT Joins with GE Healthcare to Validate Alzheimer Disease Biomarker nanoMR, Stratos Partner on Pathogen Detection Micro-Hall Detector Counts Rare CTCs in Clinical Samples TGen Isolation Method May Help Diagnose Kidney Disease Early ...
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*  Study: Blood markers may help determine Type 2 diabetes risk
... Click to Print. Email this. close. Study: Blood markers may help determine Type 2 diabetes risk. By Allison Cerra. DALLAS A new study published in Circulation Research, a journal of the American Heart Association, found that blood levels of some ribonucleic acids known as microRNAs vary among those with Type 2 diabetes or those who develop the disease, compared with healthy people. MicroRNA comprises shorter molecular chains than so-called messenger RNA, which takes the genetic information contained within the DNA and allows it to be turned into proteins with various functions, and previously has been linked to numerous diseases, including diabetes. Investigators analyzed microRNAs in blood samples of the Bruneck study a large population-based survey of heart and other major diseases and found that after analyzing initial blood-sample screens in 1995, 13 microRNAs found in diabetics had distinct differences than healthy controls' blood samples. The scientists further analyzed these 13 microRNAs to identi...
http://drugstorenews.com/print/367381
*  Insight & Intelligence™ Related To | GEN
Wound Care Pipelines Expand with Bioactive Market. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. FDA Nominee Driven by "Data, Data, Data". More GEN Exclusives ». Jobs Report: Data, Business, and Regulatory ... Wound Care Pipelines Expand with Bioactive Market. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. FDA Nominee Driven by "Data, Data, Data". More GEN Exclusives ». Top 25 Biotech Companies of 2015. Top 10 Pharma Firms of 2015. Market & Tech Analysis. GEN Exclusives More. Wound Care Pipelines Expand with Bioactive Market Graying Populations, New Technologies Driving Demand... Top 10 Pharma Firms of 2015 Which Traditional Drug Developers Generated the... Twists and Turns in Protein Expression In Early Drug Discovery it’s Often... Eye on Circulating Biomarkers These biomarkers are driving the liquid biopsy field. Top 20 Diabetes Drugs Find out which treatments are the biggest sellers. Early Detection: The Real Way to Beat Cancer Several new biomarkers may be the key ...
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*  CHARTER
... return to CHARTER site. Publication Abstract Display. Type: Poster. Title: CSF biomarker profile in HIV patients with and without CSF viral escape. Authors: P rez-Valero I, Letendre S, Heaton R, Ellis R, MCCutchan A, Simpson D, Deutsch R, Grant I, and the CHARTER Group. Date: 03-03-2014. Abstract: Background: The association between levels of inflammatory biomarkers and CSF Viral Escape CVE is unexplored. Methodology: Cross-sectional analysis performed to compare levels of inflammatory biomarkers in patients with and without CVE HIV-RNA 50cop/mL in CSF and 50cop/mL in plasma. Individuals followed in two large HIV Cohorts, tested for CSF and blood biomarkers of immune activation CXCL10, IL6, TNF-Alpha, MCP-1 and WBC were included. Blood and CSF biomarkers along with demographics and HIV-related clinical data of patients with and without CVE were compared using multivariable logistic regression. Results: 296 patients were evaluated: Mean age 46.6 years, 58% Caucasian, 87% male with a mean time of HIV-infec...
https://publications.hivresearch.ucsd.edu/index.php?token=b37e64a8e5c72bef0450a2d432b31743&sort_type=abs&abstract_id=2263
*  GEN News Highlights Related To | GEN
Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Analysis of the RNA-Seq and SCA Publication Landscape. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Analysis of the RNA-Seq and SCA Publication Landscape. RNA Splicing Factor Linked with Causes of Breast Cancer. Analysis of the RNA-Seq and SCA Publication Landscape RNA-Seq and SCA Could Have a... GEN News Highlights Related to Gentris, China’s SIPM Collaborate on Biomarker Discovery CE Mark for Rapid Acute Kidney Injury Test Blood Biomarker Identifies Early Lung Cancer Fast Forward, Ezose Partner on MS Biomarker Discovery Agenix Nabs Diagnostic Platform and TB Biomarker New Breast Cancer Biomarker and Therapeutic Target Naked Eye ELISA Developed as Biomarker Diagnostic CTC Distributes Data Analysis and Biomarker Platform in Japan Response Genetics Offers New Test for Lung Cancer Biomarker Biomarker for Youth Depression and Anxiety Discovered Childhood Cancer-Linked Mutations May Point Toward New Targets $2M Grant Launches...
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*  Targeting Pre-Plaque Clumps May Boost Resistance to Diabetes | GEN News Highlights | GEN
GEN. Jobs Report: Data, Business, and Regulatory Savvy Driving New Hiring. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Linking Phenotypes and Modes of Action Through High-Content Screen Fingerprints. More GEN Exclusives ». Jobs Report: Data, Business, and Regulatory Savvy Driving New Hiring. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Linking Phenotypes and Modes of Action Through High-Content Screen Fingerprints. More GEN Exclusives ». MORE GEN. Market & Tech Analysis. GEN Exclusives More. Linking Phenotypes and Modes of Action Through High-Content Screen Fingerprints The Use of High-Content Screening as... GEN News Highlights More » Nov 13, 2013 Targeting Pre-Plaque Clumps May Boost Resistance to Diabetes Page 1 of 1 The sketchy picture of amyloid formation in type 2 diabetes has become a little more detailed, thanks to a structural study that applied the techniques of 2D infrared IR spectroscopy and isotope labeling. Zanni said. Zanni said. Zanni and his collab...
http://genengnews.com/gen-news-highlights/targeting-pre-plaque-clumps-may-boost-resistance-to-diabetes/81249112/?kwrd=University of Wisconsin - Madison
*  GEN News Highlights Related To | GEN
Jobs Report: Data, Business, and Regulatory Savvy Driving New Hiring. Wound Care Pipelines Expand with Bioactive Market. FDA Nominee Driven by "Data, Data, Data". Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Transitioning from Traditional Assay Formats to HTRF Technology. Jobs Report: Data, Business, and Regulatory Savvy Driving New Hiring. Wound Care Pipelines Expand with Bioactive Market. FDA Nominee Driven by "Data, Data, Data". Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Transitioning from Traditional Assay Formats to HTRF Technology. GEN News Highlights Related to Multiplicom, ICAN, ICM to Develop Tests for Cardiovascular, Metabolic, and Neurological Diseases New Indiana Institute Targets Metabolic Disorders Catching Alzheimer’s Early On with Blood-Based Biomarkers Neurelis, Biotie Therapies Enter Option and Merger Agreement Stopping MS Inflammation in Its Tracks ADA, Lilly Partner on Grant-Giving Diabetes Research Program Biomarker Study Suggests Potential Al...
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*  Protein in Fat Cells Protects Against Diabetes | GEN News Highlights | GEN
Protein in Fat Cells Protects Against Diabetes. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. FDA Nominee Driven by "Data, Data, Data". Analysis of the RNA-Seq and SCA ... Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. FDA Nominee Driven by "Data, Data, Data". Jobs. Market & Tech Analysis. Analysis of the RNA-Seq and SCA Publication Landscape RNA-Seq and SCA Could Have a... The protein, SIRT1, is a deacetylase enzyme that in mice has already been shown to protect against the development of liver steatosis and insulin resistance as a result of a high-fat diet HFD. Most notably, the white fat cells in these modified animals exhibited an altered gene expression profile that was very similar to that observed in the adipocytes of wild-type mice fed a HFD. Further studies showed that in normal mice given a HFD, the SIRT1 protein is cleaved by caspase-1, an enzyme induced by inflammation. The researchers say their studies thus demonstrate that SIRT1 is required for the mainte...
http://genengnews.com/gen-news-highlights/protein-in-fat-cells-protects-against-diabetes/81247164/?kwrd=Diabetes
*  BioCat and Alpco Sign Distribution Agreement | GEN News Highlights | GEN
BioCat and Alpco Sign Distribution Agreement. GEN. The Pons Asinorum of Diagnostic Genomics. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. FDA Nominee Driven by "Data, Data, Data". Transitioning from Traditional Assay Formats to HTRF Technology. Jobs Report: Data, Business, and Regulatory ... The Pons Asinorum of Diagnostic Genomics. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. FDA Nominee Driven by "Data, Data, Data". Transitioning from Traditional Assay Formats to HTRF Technology. MORE GEN. Market & Tech Analysis. Jobs. Transitioning from Traditional Assay Formats to HTRF Technology Sensitivity of Fluorescence Coupled to Low... The Pons Asinorum of Diagnostic Genomics Non-Small Cell Lung Carcinoma: ROSter for... GEN News Highlights More » Nov 19, 2012 BioCat and Alpco Sign Distribution Agreement Page 1 of 1 BioCat, a distributor of research reagents and technologies in the fields of genomics, proteomics, and cell biology, signed an exclusive distribution agreement ...
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*  Insight & Intelligence™ Related To | GEN
Jobs Report: Data, Business, and Regulatory Savvy Driving New Hiring. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Jobs Report: Data, Business, and Regulatory Savvy Driving New Hiring. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Top 25 Biotech Companies of 2015. Insight & Intelligence Related to AstraZeneca Partners on miRNA Inhibitors Value of Oncology Drugs Recognized Over Time Our Understanding of the Benefits and Risks of Therapies Evolves over Time as Evidence Accumulates JobWatch: More Layoffs Loom as M&A Zooms 2015 Allergan Layoffs Surpass Last Year’s Total, Yet Deals Aren’t the Only Factor in Job Cuts 20 Top-Paid Research Institute Leaders of 2015 Meet the Movers and Shakers Who Made the Most at Their Institutions 14 Industry-Venture Alliances, 2015 Edition Where Biopharma Innovation and VC Investment Can Add Up To Successful Startups At the Heart of the Matter: The Genomics Underlying Cardiovascular Disease It’s Important to Examine the Associated Genetic ...
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*  What is a Biomarker?
News A-Z. Health A-Z. Clinical Diagnostics. Medical News 'Tweets'. Health. News. By Dr Ananya Mandal, MD Biomarkers short for biological markers are biological measures of a biological state. Biomarkers are the measures used to perform a clinical assessment such as blood pressure or cholesterol level and are used to monitor and predict health states in individuals or across populations so that appropriate therapeutic intervention can be planned. Biomarkers may be used alone or in combination to assess the health or disease state of an individual. Every biological system for example the cardiovascular system, metabolic system or the immune system has its own specific biomarkers. Many of these biomarkers are relatively easy to measure and form part of routine medical examinations. Characteristics of an ideal biomarker An ideal biomarker has certain characteristics that make it appropriate for checking a particular disease condition. Biomarkers as health and disease predictors Biomarkers are used to predict seri...
http://news-medical.net/health/What-is-a-Biomarker.aspx
*  GEN Articles Related To | GEN
GEN Articles Related To. GEN. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Analysis of the RNA-Seq and SCA Publication Landscape. Standardization of High Content Imaging and Informatics. More GEN Exclusives ». Exclusives. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Analysis of the RNA-Seq and SCA Publication Landscape. Standardization of High Content Imaging and Informatics. More GEN Exclusives ». Top 25 Biotech Companies of 2015. MORE GEN. Jobs. Market & Tech Analysis. GEN Exclusives More. Analysis of the RNA-Seq and SCA Publication Landscape RNA-Seq and SCA Could Have a... GEN Articles Related to Vaccine World China Tutorials:. Hastening Epitope Discovery for Vaccines Feature Articles:. Adults Now Drive Growth of Vaccine Market Feature Articles:. Biomarker Assay Use Increases Feature Articles:. DNA Vaccines Meeting Feature Articles:. DNA Vaccines Inch Toward Human Use Feature Articles:. Ramping Up Flu Vaccine Efforts Feature Articles:. Bioreactor and Fermentor Ma...
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Linking Phenotypes and Modes of Action Through High-Content Screen Fingerprints. Jobs Report: Data, Business, and Regulatory Savvy Driving New Hiring. Wound Care Pipelines Expand with Bioactive Market. More GEN Exclusives ». Linking Phenotypes and Modes of Action Through High-Content Screen Fingerprints. Jobs Report: Data, Business, and Regulatory Savvy Driving New Hiring. Wound Care Pipelines Expand with Bioactive Market. More GEN Exclusives ». Market & Tech Analysis. GEN Exclusives More. Linking Phenotypes and Modes of Action Through High-Content Screen Fingerprints The Use of High-Content Screening as... Wound Care Pipelines Expand with Bioactive Market Graying Populations, New Technologies Driving Demand... Denovo Partners with ALS Nonprofit to ID Biomarkers Study Points to Potential Biomarker for Atherosclerosis Empire Genomics Nabs Prostate Cancer Biomarker from Cornell Diet, Exercise...Epigenetics. Qiagen Picks Up New Cancer Biomarkers in Two Deals Biomarker Study Suggests Potential Alternative to Colo...
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FDA Nominee Driven by "Data, Data, Data". Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Linking Phenotypes and Modes of Action Through High-Content Screen Fingerprints. Jobs Report: Data, Business, and Regulatory Savvy Driving New Hiring. FDA Nominee Driven by "Data, Data, Data". Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Linking Phenotypes and Modes of Action Through High-Content Screen Fingerprints. Jobs Report: Data, Business, and Regulatory Savvy Driving New Hiring. Linking Phenotypes and Modes of Action Through High-Content Screen Fingerprints The Use of High-Content Screening as... Axes Partnership with Galapagos Scientists Shed Light on Link Between 9p21 SNPs, CAD, and Vascular Diseases Scientists Implicate Potassium Channel Mutations in Severe Hypertension Nonfasting Triglyceride Levels Linked to Ischemic Stroke Risk Moleculence to Use Pronota's Platforms to Find Biomarkers for Stroke Santaris Pharma Licenses miRNA from MGH for Development in Cardiovascular...
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*  Best of the Web Related To | GEN
Best of the Web Related To. GEN. FDA Nominee Driven by "Data, Data, Data". Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Wound Care Pipelines Expand with Bioactive Market. The Pons Asinorum of Diagnostic Genomics. Analysis of the RNA-Seq and SCA Publication Landscape. More GEN Exclusives ». Exclusives. FDA Nominee Driven by "Data, Data, Data". Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Wound Care Pipelines Expand with Bioactive Market. The Pons Asinorum of Diagnostic Genomics. Analysis of the RNA-Seq and SCA Publication Landscape. More GEN Exclusives ». Top 25 Biotech Companies of 2015. MORE GEN. Jobs. Best of the Web. GEN Exclusives More. Analysis of the RNA-Seq and SCA Publication Landscape RNA-Seq and SCA Could Have a... Twists and Turns in Protein Expression In Early Drug Discovery it’s Often... Best of the Web Related to Adapting Protein Expression for HT Interactive Timeline—50 Years of Protein Struture Determination Protein Crystallography Universe Proteinch...
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*  GEN News Highlights Related to Antibodies | GEN
GEN News Highlights Related to Antibodies. GEN. Transitioning from Traditional Assay Formats to HTRF Technology. Analysis of the RNA-Seq and SCA Publication Landscape. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. FDA Nominee Driven by "Data, Data, Data". Standardization of High Content Imaging and Informatics. The Pons Asinorum of Diagnostic Genomics. More GEN Exclusives ». Exclusives. Transitioning from Traditional Assay Formats to HTRF Technology. Analysis of the RNA-Seq and SCA Publication Landscape. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. FDA Nominee Driven by "Data, Data, Data". Standardization of High Content Imaging and Informatics. The Pons Asinorum of Diagnostic Genomics. More GEN Exclusives ». Top 10 Pharma Firms of 2015. Top 25 Biotech Companies of 2015. MORE GEN. Jobs. Market & Tech Analysis. GEN Exclusives More. Analysis of the RNA-Seq and SCA Publication Landscape RNA-Seq and SCA Could Have a... The Pons Asinorum of Diagnostic Genomics Non-Small C...
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*  Insight & Intelligence™ Related To | GEN
Insight & Intelligence Related To. GEN. Standardization of High Content Imaging and Informatics. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Analysis of the RNA-Seq and SCA Publication Landscape. FDA Nominee Driven by "Data, Data, Data". More GEN Exclusives ». Standardization of High Content Imaging and Informatics. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Analysis of the RNA-Seq and SCA Publication Landscape. FDA Nominee Driven by "Data, Data, Data". More GEN Exclusives ». Top 25 Biotech Companies of 2015. MORE GEN. Jobs. Market & Tech Analysis. GEN Exclusives More. See the Rare Antibody In this literature review, learn how researchers converted stem cells to dendritic cells using agonist antibodies. Defenders against Death A review of literature describing how researchers used intracellular combinatorial libraries to select antibodies that protected cells from death. Key Questions for Cell-Line Acquisition, Storage, and Usage Make sure your cell lines are aut...
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Standardization of High Content Imaging and Informatics. FDA Nominee Driven by "Data, Data, Data". Transitioning from Traditional Assay Formats to HTRF Technology. Jobs Report: Data, Business, and Regulatory Savvy Driving New Hiring. Standardization of High Content Imaging and Informatics. FDA Nominee Driven by "Data, Data, Data". Transitioning from Traditional Assay Formats to HTRF Technology. Jobs Report: Data, Business, and Regulatory Savvy Driving New Hiring. Top 10 Pharma Firms of 2015. GEN Exclusives More. Top 10 Pharma Firms of 2015 Which Traditional Drug Developers Generated the... Transitioning from Traditional Assay Formats to HTRF Technology Sensitivity of Fluorescence Coupled to Low... GEN News Highlights Related to Heterodimer Immunoassay Kit KineMed Wins $1.2M from MJFF for Parkinson Disease Biomarker Program Plexpress, Phalanx Offer Biomarker Discovery and Validation Service Micro-Hall Detector Counts Rare CTCs in Clinical Samples Isolation and Imaging of CTCs Enabled with New Technology Jansse...
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FDA Nominee Driven by "Data, Data, Data". Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Analysis of the RNA-Seq and SCA Publication Landscape. More GEN Exclusives ». FDA Nominee Driven by "Data, Data, Data". Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Analysis of the RNA-Seq and SCA Publication Landscape. More GEN Exclusives ». GEN Exclusives More. Ink Diabetes Biomarker Deal Abbott Pays Reata $400M in Expanded Antioxidant Inflammation Modulator Deal Ember Therapeutics Launched with $34M to Focus on Metabolic Disorders Researchers Find Approach to Hold Type 1 Diabetes Back JDRF Provides $2.2M Support for KalVista’s Kallikrein Inhibitor DME Drug Akebia Spins out Aerpio to Develop Tie-2 Activators and HIF-1a Stabilizers PCT Inks Manufacturing and Service Deal with Islet for Diabetes Transplantation Therapy FDA Asks BMS, AstraZeneca for More Clinical Data for Antidiabetic EMD Millipore, Proteomics International to Validate Diabetic Nephropathy Biomarkers Islet Sciences...
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*  Qiagen Page | GEN
Qiagen Page. GEN. FDA Nominee Driven by "Data, Data, Data". Analysis of the RNA-Seq and SCA Publication Landscape. The Pons Asinorum of Diagnostic Genomics. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. More GEN Exclusives ». Exclusives. FDA Nominee Driven by "Data, Data, Data". Analysis of the RNA-Seq and SCA Publication Landscape. The Pons Asinorum of Diagnostic Genomics. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. More GEN Exclusives ». Top 25 Biotech Companies of 2015. Enabling a Paradigm Shift in Precision Medicine. MORE GEN. GEN Webinars. Best Apps. Market & Tech Analysis. Jobs. GEN Exclusives More. The Pons Asinorum of Diagnostic Genomics Non-Small Cell Lung Carcinoma: ROSter for... Analysis of the RNA-Seq and SCA Publication Landscape RNA-Seq and SCA Could Have a... Qiagen - Related Content. Assay Tutorials:. Qiagen Boasts Broad Purview from Molecular Biology to Molecular Diagnostics. Assay Tutorials:. Efficient Detection and Analysis of miRNAs. This Time La...
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GEN Articles Related To. GEN. Linking Phenotypes and Modes of Action Through High-Content Screen Fingerprints. Standardization of High Content Imaging and Informatics. The Pons Asinorum of Diagnostic Genomics. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. FDA Nominee Driven by "Data, Data, Data". More GEN Exclusives ». Exclusives. Analysis of the RNA-Seq and SCA ... Linking Phenotypes and Modes of Action Through High-Content Screen Fingerprints. Standardization of High Content Imaging and Informatics. The Pons Asinorum of Diagnostic Genomics. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. FDA Nominee Driven by "Data, Data, Data". More GEN Exclusives ». MORE GEN. Jobs. Market & Tech Analysis. GEN Exclusives More. Analysis of the RNA-Seq and SCA Publication Landscape RNA-Seq and SCA Could Have a... The Pons Asinorum of Diagnostic Genomics Non-Small Cell Lung Carcinoma: ROSter for... Stopping the Misidentification of Cell Lines Feature Articles:. coli Feature Articles:. G...
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GEN Polls Related To. GEN. Standardization of High Content Imaging and Informatics. Analysis of the RNA-Seq and SCA Publication Landscape. Linking Phenotypes and Modes of Action Through High-Content Screen Fingerprints. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Wound Care Pipelines Expand with Bioactive Market. The Pons Asinorum of Diagnostic Genomics. FDA Nominee Driven by "Data, Data, Data". More GEN Exclusives ». Exclusives. Standardization of High Content Imaging and Informatics. Analysis of the RNA-Seq and SCA Publication Landscape. Linking Phenotypes and Modes of Action Through High-Content Screen Fingerprints. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Wound Care Pipelines Expand with Bioactive Market. The Pons Asinorum of Diagnostic Genomics. FDA Nominee Driven by "Data, Data, Data". More GEN Exclusives ». Top 25 Biotech Companies of 2015. Magazine. Advertorial: TangenX. MORE GEN. Market & Tech Analysis. Jobs. GEN Exclusives More. The Pons Asinorum of D...
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GEN Articles Related To. GEN. Linking Phenotypes and Modes of Action Through High-Content Screen Fingerprints. Standardization of High Content Imaging and Informatics. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. FDA Nominee Driven by "Data, Data, Data". The Pons Asinorum of Diagnostic Genomics. Analysis of the RNA-Seq and SCA Publication Landscape. More GEN Exclusives ». Exclusives. Linking Phenotypes and Modes of Action Through High-Content Screen Fingerprints. Standardization of High Content Imaging and Informatics. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. FDA Nominee Driven by "Data, Data, Data". The Pons Asinorum of Diagnostic Genomics. Analysis of the RNA-Seq and SCA Publication Landscape. More GEN Exclusives ». Top 25 Biotech Companies of 2015. MORE GEN. Jobs. Market & Tech Analysis. GEN Exclusives More. The Pons Asinorum of Diagnostic Genomics Non-Small Cell Lung Carcinoma: ROSter for... GEN Articles Related to SBS Conference Features Diverse New Product...
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*  Bayer Licenses Brenda-Amenda Database for Target Research | GEN News Highlights | GEN
Bayer Licenses Brenda-Amenda Database for Target Research. GEN. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Analysis of the RNA-Seq and SCA Publication Landscape. The Pons Asinorum of Diagnostic Genomics. More GEN Exclusives ». Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Analysis of the RNA-Seq and SCA Publication Landscape. The Pons Asinorum of Diagnostic Genomics. More GEN Exclusives ». Top 25 Biotech Companies of 2015. MORE GEN. Jobs. GEN Exclusives More. The Pons Asinorum of Diagnostic Genomics Non-Small Cell Lung Carcinoma: ROSter for... GEN News Highlights More » Dec 6, 2006 Bayer Licenses Brenda-Amenda Database for Target Research Page 1 of 1 Bayer HealthCare gained access to Biobase’s enzyme and metabolism research database, according to a license agreement between the two companies. The Brenda-Amenda database summarizes more than 50 years worth of research in this field. Brenda-Amenda is a relational database that contains manually-curated biochemical and...
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GEN Articles Related To. GEN. FDA Nominee Driven by "Data, Data, Data". Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Standardization of High Content Imaging and Informatics. The Pons Asinorum of Diagnostic Genomics. Analysis of the RNA-Seq and SCA Publication Landscape. More GEN Exclusives ». Exclusives. FDA Nominee Driven by "Data, Data, Data". Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Standardization of High Content Imaging and Informatics. The Pons Asinorum of Diagnostic Genomics. Analysis of the RNA-Seq and SCA Publication Landscape. More GEN Exclusives ». Top 25 Biotech Companies of 2015. MORE GEN. Jobs. Market & Tech Analysis. GEN Exclusives More. The Pons Asinorum of Diagnostic Genomics Non-Small Cell Lung Carcinoma: ROSter for... GEN Articles Related to Eppendorf, Vela Develop Nucleic Acid Extraction Platform BioMarket Trends:. Improving Molecular Genetic Testing Feature Articles:. Genomic Data in Patients’ Hands Feature Articles:. Use of Digital PCR Ramp...
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GEN Articles Related To. GEN. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Linking Phenotypes and Modes of Action Through High-Content Screen Fingerprints. Analysis of the RNA-Seq and SCA Publication Landscape. FDA Nominee Driven by "Data, Data, Data". Wound Care Pipelines Expand with Bioactive Market. More GEN Exclusives ». Exclusives. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Linking Phenotypes and Modes of Action Through High-Content Screen Fingerprints. Analysis of the RNA-Seq and SCA Publication Landscape. FDA Nominee Driven by "Data, Data, Data". Wound Care Pipelines Expand with Bioactive Market. More GEN Exclusives ». Top 25 Biotech Companies of 2015. MORE GEN. Jobs. BioPerspectives. Market & Tech Analysis. GEN Exclusives More. Analysis of the RNA-Seq and SCA Publication Landscape RNA-Seq and SCA Could Have a... GEN Articles Related to Flick a Switch to Burn More Fat Feature Articles:. Regulatory Environment Warms Up to Obesity Drugs Feature Articles:. PCR...
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*  GEN News Highlights Related To | GEN
Analysis of the RNA-Seq and SCA Publication Landscape. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Analysis of the RNA-Seq and SCA Publication Landscape. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Analysis of the RNA-Seq and SCA Publication Landscape RNA-Seq and SCA Could Have a... GEN News Highlights Related to Scientists Say that Jhdm2a Gene Is Associated with Obesity Investigators Throw Genetic Light on Role of DHEAS in Aging and Related Diseases Whole-Exome Sequencing Implicates GRIN2A and TRRAP Mutations in Melanoma Researchers Claim That Measuring Seven Proteins Could Help Anticipate Melanoma Relapse Mucin Gene Promotor SNP Linked to Risk of Pulmonary Fibrosis Researchers Identify Brain Cell Protein as Potential Target for Obesity and Type 2 Diabetes Researchers Identify New Malarial Drug Resistance Gene Researchers Suggest Role for Hypothalamic PPAR-Gamma in Diabetes Drug-Related Weight Gain Scientists Claim Region of Hypothalamus Could Represent New Targe...
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*  GEN News Highlights Related To | GEN
Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. GEN News Highlights Related to 25 Diabetes Drugs in the Pipeline Right Now Lotus Raises $26M in Series A to Progress Recombinant Collagen Type VII Platform Scientists Trigger White Fat to Become Brown Fat-Like to Treat Obesty and Type 2 Diabetes EMA Recommends Cautious Prescribing of Takeda's Actos due to Bladder Cancer Risk Scientists Develop DNA Sensor that Allows Personal Glucose Monitors to Quantitatively Measure Wide Range of Analytes Axxam and Polyphor Receive €3.1M for GLP-1 Receptor Diabetes Program Amarantus and Generex to Develop Cell Replacement Therapy for Late-Stage Diabetes Intercept Signs Potentially $163M Diabetes Drug Development Deal with Servier Scientists Find High-Fat Diet Causes Beta Cell Dysfunction Leading to Type 2 Diabetes Diamyd Shifts Development Focus from Diabetes to Pain and CNS Disorders Santarus and Depomed Amend U.S. GEN EDITORIAL Editorial Sta...
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*  GEN News Highlights Related To | GEN
The Pons Asinorum of Diagnostic Genomics. FDA Nominee Driven by "Data, Data, Data". Analysis of the RNA-Seq and SCA Publication Landscape. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. The Pons Asinorum of Diagnostic Genomics. FDA Nominee Driven by "Data, Data, Data". Analysis of the RNA-Seq and SCA Publication Landscape. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Analysis of the RNA-Seq and SCA Publication Landscape RNA-Seq and SCA Could Have a... Human GI Cells Retrained to Make Insulin Diagnosing Type 1 Diabetes with Nanotechnology Boehringer Ingelheim, Zealand Expand Peptide Partnership in Up to $396M Deal Sanofi Licenses Afrezza from MannKind for Up to $925M AstraZeneca, MTPC Partner to Validate Diabetic Nephropathy Targets Hyperion Scuttles T1D Drug, Citing Falsified Data Warnings, Postmarket Studies Tip the Scale for Weight Loss Drug Contrave Obesity and Stress Present Double Whammy against Good Health Hyperion, Clal Biotech Call Truce in Dispute Over Diabet...
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*  GEN News Highlights Related To | GEN
FDA Nominee Driven by "Data, Data, Data". Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Transitioning from Traditional Assay Formats to HTRF Technology. FDA Nominee Driven by "Data, Data, Data". Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Transitioning from Traditional Assay Formats to HTRF Technology. GEN News Highlights Related to Vitae Earns $8M Milestone from Boehringer Ingelheim Boehringer Ingelheim, Zealand Expand Peptide Partnership in Up to $396M Deal Sanofi Licenses Afrezza from MannKind for Up to $925M AstraZeneca, MTPC Partner to Validate Diabetic Nephropathy Targets Hyperion Scuttles T1D Drug, Citing Falsified Data Warnings, Postmarket Studies Tip the Scale for Weight Loss Drug Contrave Obesity and Stress Present Double Whammy against Good Health Hyperion, Clal Biotech Call Truce in Dispute Over Diabetes Compound New Class of "Good Fats" Protects against Diabetes Sanofi Board Ousts CEO Viehbacher Lilly, Boehringer Ingelheim Restructure Diabetes Alliance ...
http://genengnews.com/more/related/gen-news-highlights/4/8539/?page=2
*  GEN News Highlights Related To | GEN
Analysis of the RNA-Seq and SCA Publication Landscape. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Analysis of the RNA-Seq and SCA Publication Landscape. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. RNA Splicing Factor Linked with Causes of Breast Cancer. Market & Tech Analysis. Analysis of the RNA-Seq and SCA Publication Landscape RNA-Seq and SCA Could Have a... GEN News Highlights Related to Horizon, AstraZeneca Seek Kinase-Targeting Cancer Drugs MYC Disrupts Cancer’s Rhythm Channel Molecular Noise to Keep Cells Healthy Early Circulating Lung Cancer DNA Found by Hopkins Team AstraZeneca Answers the DREAM Challenge’s Call to Find Combination Cancer Therapies ImmunoCellular Therapeutics Receives $19.9 Million from CIRM for Phase III Glioblastoma Trial New Evidence Gained for Arming the Immune System to Fight Cancer Aduro Biotech to Acquire BioNovion Dako Joins Merck, Pfizer to Develop CDx for Avelumab MedImmune, 3M Partner to Develop TLR Agonist Cancer Treatments M...
http://genengnews.com/more/related/gen-news-highlights/4/31095/
*  Biogen Idec and Portola Forge $45M Pact to Tackle Autoimmune and Inflammatory Diseases | GEN News
Biogen Idec and Portola Forge $45M Pact to Tackle Autoimmune and Inflammatory Diseases. The Pons Asinorum of Diagnostic Genomics. FDA Nominee Driven by "Data, Data, Data". Analysis of the RNA-Seq and SCA Publication Landscape. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. The Pons Asinorum of Diagnostic Genomics. FDA Nominee Driven by "Data, Data, Data". Analysis of the RNA-Seq and SCA Publication Landscape. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Top 25 Biotech Companies of 2015. Jobs. Market & Tech Analysis. GEN News Highlights More » Oct 27, 2011 Biogen Idec and Portola Forge $45M Pact to Tackle Autoimmune and Inflammatory Diseases Page 1 of 1 Biogen Idec is paying Portola Pharmaceuticals $36 million in cash and $9 million in equity under an exclusive, worldwide collaboration to conduct R D in autoimmune and inflammatory diseases. The collaboration s lead molecule, Portola s Phase I PRT062607, has been shown to be a highly potent and specific oral inhibitor o...
http://genengnews.com/gen-news-highlights/biogen-idec-and-portola-forge-45m-pact-to-tackle-autoimmune-and-inflammatory-diseases/81245883/
*  | GEN
GEN. FDA Nominee Driven by "Data, Data, Data". Standardization of High Content Imaging and Informatics. Linking Phenotypes and Modes of Action Through High-Content Screen Fingerprints. RNA-Based Therapeutics and Vaccines. Transitioning from Traditional Assay Formats to HTRF Technology. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Wound Care Pipelines Expand with Bioactive Market. Jobs Report: Data, Business, and Regulatory Savvy Driving New Hiring. More GEN Exclusives ». Exclusives. FDA Nominee Driven by "Data, Data, Data". Standardization of High Content Imaging and Informatics. Linking Phenotypes and Modes of Action Through High-Content Screen Fingerprints. RNA-Based Therapeutics and Vaccines. Transitioning from Traditional Assay Formats to HTRF Technology. Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes. Wound Care Pipelines Expand with Bioactive Market. Jobs Report: Data, Business, and Regulatory Savvy Driving New Hiring. More GEN Exclusives ». 1000 Genomes Project ...
http://genengnews.com/contentframe.aspx?code=bkXSmz1FOA3BXJtK60Wi3pl0HKQ8DYLN/xaagn7asrjqvUROZ/teo5d32yBQWLEy
*  ABT-510
abt abt abt is a molecular therapeutic drug that was the subject of research as a potential treatment for cancer according to the journal of clinical oncology abt is a subcutaneously sc administered nonapeptide thrombospondin analogue following inconclusive phase i clinical trials a phase ii study of abt for treatment of metastatic melanoma failed to reach its primary endpoint resulting in termination of the study only three out of twenty one patients reached the primary endpoint of progression free survival at weeks but these three patients remained progression free for and weeks however biomarker data collected during this study showed a decrease in vegf c circulating endothelial cells and cd and cd counts and a maximum tolerated dose has still not been established further study could consider a higher dose and or combination treatment references category angiogenesis inhibitors...
https://en.wikipedia.org/wiki/ABT-510
*  AD biomarker
... redirect alzheimer s disease biomarkers...
https://en.wikipedia.org/wiki/AD_biomarker
*  Microsatellite instability at chromosome 8p in non-small cell lung cancer is associated with lymph
... node metastasis and squamous differentiation - University of Regensburg Publication Server. Microsatellite instability at chromosome 8p in non-small cell lung cancer is associated with lymph node metastasis and squamous differentiation. and Zieglmeier, Ulrike and Foerster, Julia and Merk, Johannes and Blaszyk, Hagen and Pfeifer, Michael and Hofstaedter, Ferdinand and Hartmann, Arndt 2003 Microsatellite instability at chromosome 8p in non-small cell lung cancer is associated with lymph node metastasis and squamous differentiation. We studied the frequency of microsatellite instability MSI and loss of heterozygosity LOH at chromosome 8p in early stage non-small cell lung cancer NSCLC of 47 patients with stage I or II disease 25 squamous cell carcinomas and 22 adenocarcinomas. We studied the frequency of microsatellite instability MSI and loss of heterozygosity LOH at chromosome 8p in early stage non-small cell lung cancer NSCLC of 47 patients with stage I or II disease 25 squamous cell carcinomas and 22 ad...
http://epub.uni-regensburg.de/15427/
*  ARS | Publication request: HIGHLY POLYMORPHIC MICROSATELLITE DNA MARKERS FOR U.S. SUGARCANE GERMPLAS
ARS. Publication request: HIGHLY POLYMORPHIC MICROSATELLITE DNA MARKERS FOR U.S. SUGARCANE GERMPLASM EVALUATION AND VARIETY FINGERPRINTING ARS : Research. ARS Home. About ARS. International Programs. Related Topics Programs and Projects. ARS National Programs. ARS Office of International Research Programs. ARS Office of International Research Programs Regional Contacts. Title: HIGHLY POLYMORPHIC MICROSATELLITE DNA MARKERS FOR U.S. SUGARCANE GERMPLASM EVALUATION AND VARIETY FINGERPRINTING Authors. Submitted to: Plant and Animal Genome Conference Publication Type: Abstract Only Publication Acceptance Date: September 30, 2004 Publication Date: January 15, 2005 Citation: Pan, Y.B., Comstock, J.C., Scheffler, B.E. Highly Polymorphic Microsatellite DNA Markers for U.S. Sugarcane Germplasm Evaluation and Variety Fingerprinting. Technical Abstract: Sugarcane breeding programs can be enhanced by the utilization of a diverse group of DNA markers to genetically characterize parental lines and the progeny that are produc...
http://ars.usda.gov/research/publications/publications.htm?SEQ_NO_115=170454
*  Genetic variability and efficiency of DNA microsatellite markers for paternity testing in horse bree
... ds from the Brazilian Marajó archipelago. . . . Services on Demand Article. English pdf. English epdf. Article in xml format. Article references. How to cite this article Curriculum ScienTI. Automatic translation. Send this article by e-mail Indicators. Cited by SciELO. Access statistics. Related links. Cited by Google. Similars in SciELO. Similars in Google. uBio. Share. More More. Permalink. Genetics and Molecular Biology On-line version ISSN 1678-4685 Genet. Mol. Biol. vol.31 no.1 São Paulo 2008 http://dx.doi.org/10.1590/S1415-47572008000100014 ANIMAL GENETICS SHORT COMMUNICATION. Genetic variability and efficiency of DNA microsatellite markers for paternity testing in horse breeds from the Brazilian Maraj archipelago. S vio P. Reis, Evonnildo C. Gon alves; Artur Silva; Maria P.C. Schneider Laborat rio de Polimorfismo de DNA, Departamento de Gen tica, Universidade Federal do Par, Bel m, PA, Brazil Send correspondence to. ABSTRACT In this study, 15 microsatellite DNA loci used in comparative tests by th...
http://scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000100014&lng=en&nrm=iso&tlng=en
*  Microsatellite DNA marker mapping of bovine chromosome 1 for QTL affecting birth weight and prewean
... ing growth in Japanese Black Cattle Wagyu - Library Open Repository. Library. Staff. Search UTAS. Study with UTAS I am a: Future Student Domestic. Library. Research at UTAS Research Our Research. Community. UTAS Community Community Alumni Friends. Giving to UTAS. About UTAS. About UTAS Our University Council. Library. News, Events Publications News. Repository Home. Library Home. Statistics. Browse. Login. Library Open Repository. Microsatellite DNA marker mapping of bovine chromosome 1 for QTL affecting birth weight and preweaning growth in Japanese Black Cattle Wagyu. Download Statistics Download Statistics Download Statistics. Downloads. Malau-Aduli, AEO and Niibayashi, T and Kojima, T and Oshima, K and Mizoguchi, Y and Sugimoto, Y and Komatsu, M 2003 Microsatellite DNA marker mapping of bovine chromosome 1 for QTL affecting birth weight and preweaning growth in Japanese Black Cattle Wagyu. In: Association for the Advancement of Animal Breeding and Genetics Conference, 7 July 2003, Melbourne. PDF Malau...
http://eprints.utas.edu.au/2977/
*  ARS | Publication request: Imputation of microsatellite allele from dense SNP genotypes for parentag
Publication request: Imputation of microsatellite allele from dense SNP genotypes for parentage verification ARS : Research. ARS Office of International Research Programs. Title: Imputation of microsatellite allele from dense SNP genotypes for parentage verification Authors. Imputation of Microsatellite Allele from Dense SNP Genotypes for Parentage Verification. Interpretive Summary: Microsatellites are the current international molecular marker standard for genomically determining parental verification in livestock species. There is industry interest in using Single Nucleotide Polymorphisms SNP instead of microsatellites as they are easier to automate for genotyping, have a lower error rate, and can have a lower producer cost. Using data from USA dairy breeds, we have devised a simple and economical method to impute microsatellite alleles within a breed from phased SNP genotypes, using existing technology. Implementation of this method will allow dairy producers in the USA and worldwide to quickly transition...
http://ars.usda.gov/research/publications/publications.htm?SEQ_NO_115=280079
*  Microsatellite
Structures and Locations Mutation mechanism Biological effects of microsatellite mutations Effects on proteins. Analysis of microsatellites Amplification. thumb|right|DNA strand slippage during replication of an STR locus. 7 Thus, slippage changes in repetitive DNA are three orders of magnitude more common than point mutations in other parts of the genome. 8 Most slippage results in a change of just one repeat unit, and slippage rates vary for different repeat unit sizes, and within different species. Others are located in regulatory or even coding DNA - microsatellite mutations in such cases can lead to phenotypic changes and diseases. Length changes in other triplet repeats are linked to more than 40 neurological diseases in humans. Analysis of microsatellites. Microsatellites can be amplified for identification by the polymerase chain reaction PCR process, using the unique sequences of flanking regions as primers. Once the potentially useful microsatellites are determined, the flanking sequences can be use...
https://en.wikipedia.org/wiki/Microsatellite
*  Microsatellite instability
... Microsatellites are repeated sequences of DNA. While all researchers agree that microsatellites are repeat sequences, the lengths of the sequences remain in question. In a broad sense, MSI results from the inability of the mismatch repair MMR proteins to fix a DNA replication error. However, when the MMR proteins do not function normally, as in the case of MSI, this loop results in frame-shift mutations, either through insertions or deletions, yielding non-functioning proteins. 5 Researchers have shown that oxidative damage yields frame-shift mutations, thus yielding MSI, but they have yet to agree on a precise mechanism.. Microsatellite instability may result in colon cancer, gastric cancer, endometrium cancer, ovarian cancer, hepatobiliary tract cancer, urinary tract cancer, brain cancer, and skin cancers. MSI is most prevalent as the cause of colon cancers. MSI-H tumors contributing to colorectal cancer exhibit less metastasis than other derived colorectal cancer. Like MSI, VPS is linked to gastric an...
https://en.wikipedia.org/wiki/Microsatellite_instability
*  .. hMLH1 Gene Promoter Methylation is the Major Cause of Microsatellite Instability in Gastric Canc
hMLH1 Gene Promoter Methylation is the Major Cause of Microsatellite Instability in Gastric Cancer. Malfalda Pinto Instituto de Patologia e Imunologia Molecular da Universidade do Porto;. Mutation of DNA mismatch repair genes has rarely been documented in sporadic gastric carcinoma with microsatellite instability MIN 1. In sporadic colorectal carcinoma, as well as in sporadic gastric carcinoma, hMLH1 promoter methylation associated with protein loss is found in the majority of MIN cases 2,3,4. We searched for microsatellite instability in a series of 152 thoroughly studied cases of sporadic gastric carcinoma with 5 or 6 microsatellite loci and/or BAT26, using polymerase chain reaction and electrophoresis. Thirty-five cases 23.0% were positive for MIN. We analyzed 21 tumors, randomly selected from the series referred above, stratified into 14 MIN positive MIN+ and 7 MIN negative MIN-, for mutations in the repeat sequences of TGFßRII, BAX and IGFIIR genes, and for hMLH1 promoter methylation. Mutations in TGFßRI...
http://geneimprint.com/utilities/abstract-ajax.php?page=1999-dublin&id=1156793471&height=500&width=680
*  Microsatellite - Psychology Wiki
... Wikia. Skip to Content Skip to Wiki Navigation Skip to Site Navigation. Psychology Wiki Navigation On the Wiki. Edit this Page. Edit. These markers often present high levels of inter- and intra-specific polymorphism, particularly when tandem repeats number ten or greater. Once the potentially useful microsatellites are determined removing non-useful ones such as those with random inserts within the repeat region, the flanking sequences can be used to design oligonucleotide primers which will amplify the specific microsatellite repeat in a PCR reaction. Random microsatellite primers can be developed by cloning random segments of DNA from the focal species. Microsatellites developed for particular species can often be applied to closely related species, but the percentage of loci that successfully amplify may decrease with increasing genetic distance. Point mutation in the primer annealing sites in such species may lead to the occurrence of ‘ null alleles ’, where microsatellites fail to amplify in PCR ass...
http://psychology.wikia.com/wiki/Microsatellite
*  Replication error phenotype
... the positive replication error phenotype rer defines a subgroup of tumors that have been documented well in hereditary nonpolyposis colorectal cancer hnpcc more recently this phenotype also has been described in breast carcinoma and is a predictor of metastases http cat inist fr amodele affichen cpsidt category oncology...
https://en.wikipedia.org/wiki/Replication_error_phenotype
*  Microsatellite probes
... lo wing ip anthony alo at b hkstar com thu mar est previous message microsatellite probes next message www site for consultants contract labs service providers messages sorted by kevin o donnell odonnell at sasa gov uk wrote can anyone suggest a supplier of microsatellite probes ideally biotin labelled how about oncor dr anthony w i lo mb chb b med sc tel medical officer fax chemical pathology dept of pathology pager princess margaret hospital e mail anthony lo at cuhk hk lai king hill kowloon hong kong http www hkstar com alo previous message microsatellite probes next message www site for consultants contract labs service providers messages sorted by more information about the diagnost mailing list...
http://bio.net/bionet/mm/diagnost/1996-March/000660.html
*  News & Opinion Articles | The Scientist Magazine®| Page 576
News & Opinion Articles. The Scientist Magazine. Page 576. The Scientist Sign In or Register. Advertisement. The Scientist. News & Opinion. News & Opinion Covering the life sciences inside and out. Most Recent Leprosy locus By Jonathan Weitzman jonathanweitzman@hotmail.com. April 6, 2001. There appears to be a genetic contribution to the susceptibility to leprosy, and high concordance rates have been observed amongst monozygotic Indian twins. In the April Nature Genetics, Siddiqui et al. report the identification of a major susceptibility locus for leprosy Nature Genetics 2001, 27:439-441. They performed a genome-wide scan of 245 independent affected sibpairs from Southern India, using 396 highly polymorphic microsatellite markers. Only one region showed a MLS maximum lod scor 0 Comments. Why eating bacteria is good for you By Tudor Toma ttoma@mail.dntis.ro. April 6, 2001. GG given prenatally to mothers with a family history of atopy and postnatally for 6 months to their infants reduced the frequency of atopy...
http://the-scientist.com/?articles.list/categoryNo/2901/pageNo/576/
*  sequencing PCR products rich in GT microsatellite sequence
http://bio.net/bionet/mm/diagnost/1995-July/000182.html
*  .. Characterization and Functions of Imprinted Genes on Proximal Chromosome 7
characterization and functions of imprinted genes on proximal chromosome azim surani wellcome crc institute university of cambridge three imprinted genes have so far been identified on proximal chromosome peg was the first gene to be identified which encodes a c h type zinc finger protein and it exhibits paternal allele specific expression we also recently detected another novel paternally expressed gene oat which maps at bp upstream of peg and that is transcribed in the opposite direction to peg in addition a kruppel type zinc finger gene zim has also been reported within kb downstream of peg but this gene shows expression of the maternal allele only expression patterns of all these three genes are dissimilar which suggests that their expression is regulated by distinct gene specific control elements we are investigating the organization and mechanism of imprinting of these genes and their functions during development and in adults peg is the most extensively studied gene so far ...
http://geneimprint.com/utilities/abstract-ajax.php?page=1999-dublin&id=1156794575&height=500&width=680
*  High-Resolution Mutation Mapping Reveals Parallel Experimental Evolution in Yeast
... . . . High-Resolution Mutation Mapping Reveals Parallel Experimental Evolution in Yeast. DSpace/Manakin Repository. DASH Home. Faculty of Arts and Sciences. FAS Scholarly Articles View Item. Login. High-Resolution Mutation Mapping Reveals Parallel Experimental Evolution in Yeast. Download Full Text. Citable link to this page. . . Title:. High-Resolution Mutation Mapping Reveals Parallel Experimental Evolution in Yeast. Author:. Segrè, Ayellet V ; Leu, Jun-Yi ; Murray, Andrew W. Note: Order does not necessarily reflect citation order of authors. Citation:. Segrè, Ayellet V., Andrew W. Murray, and Jun-Yi Leu. 2006. High-resolution mutation mapping reveals parallel experimental evolution in yeast. PLoS Biology 4 8 : e256. Full Text Related Files:. 1514788.pdf 967.2Kb; PDF. Abstract:. Understanding the genetic basis of evolutionary adaptation is limited by our ability to efficiently identify the genomic locations of adaptive mutations. Here we describe a method that can quickly and precisely map the genetic ...
http://dash.harvard.edu/handle/1/4455977
*  Chromosome regions
... image frame diagram of a duplicated and condensed metaphase eukaryotic chromosome chromatid one of the two identical parts of the chromosome after s phase centromere the point where the two chromatids touch and where the microtubules attach short arm p long arm q several chromosome regions have been defined by convenience in order to talk about gene loci most important is the distinction between chromosome region p and chromosome region q these are virtual regions that exist in all chromosome s during cell division the molecules that compose chromosomes dna and protein s suffer a condensation process called the chromatin condensation that forms a compact and small complex called a chromatid the complexes containing the duplicated dna molecules the sister chromatids are attached to each other by the centromere the centromere divides each chromosome into two regions the smaller one which is the p region and the bigger one the q region the sister chromatids will be distributed to each daughter cell at the e...
https://en.wikipedia.org/wiki/Chromosome_regions
*  References
Mammalian Genome 2: 106-109. See also MGI. See also MGI. See also PubMed. Genome 1: 206-210. See also MGI. L., and Katz, D., eds. Princeton University Press, Princeton, NJ USA. See also PubMed. K., eds. Sinauer New York , pp. Review: PCR analysis of DNA sequences in single cells: Single sperm gene mapping and genetic disease diagnosis. Genomics 8: 415-419. See also PubMed. See also MGI. Nature Genetics 6: 363-368. See also MGI. Gene trees and the origins of inbred strains of mice. Science 254: 554-558. See also MGI. Mouse Genome 88: 7-8. Genetics by gel electrophoresis: the impact of pulsed field gel electrophoresis on mammalian genetics. Mapping genes in the mouse using single-strand conformation polymorphism analysis of recombinant inbred strains and interspecific crosses. Most classical Mus musculus domesticus laboratory mouse strains carry a Mus musculus musculus Y chromosome. Development and applications of a molecular genetic linkage map of the mouse genome. The generation of a library of PCR-analyzed m...
http://informatics.jax.org/silverbook/references.shtml
*  MGI 6.0 - Marker Mapping Data Query Results (Summary)
MGI 6.0 - Marker Mapping Data Query Results Summary. Genes Markers Query. Batch Query. Mouse Genome Browser. Mammalian Phenotype MP Browser. Human Disease OMIM Browser. Gene Expression Data Query. GO Browser. Genes Markers Query. Batch Query. Mouse Genome Browser. Batch Query. Reference Query. Gene Expression Literature Query. GO Browser. Human Disease OMIM Browser. Mammalian Phenotype MP Browser. Batch Query. Mouse Genome Browser. All MGI Reports. Batch Query. Gene Expression. Phenotypes Mutants Community Resources. Experiment Type = CROSS Experiment Chr Cross Type Mapping Panel Reference CROSS 6 Backcross J:40150 Forbes CA, Genomics 1997 May 1;41 3 :406-13 CROSS 6 Backcross J:40150 Forbes CA, Genomics 1997 May 1;41 3 :406-13 2 matching items displayed Experiment Type = IN SITU Experiment Chr Band Reference IN SITU 6 F1-G3 J:1697 Hilliker C, Mamm Genome 1992;3 8 :469-71 IN SITU 6 F1-G3 J:1697 Hilliker C, Mamm Genome 1992;3 8 :469-71 IN SITU 6 telomeric region J:1697 Hilliker C, Mamm Genome 1992;3 8 :469-71 I...
http://informatics.jax.org/searches/mapdata_report_by_marker.cgi?86511
*  High-resolution mapping of the 3D organization of chromosomes - CNRS Web site - CNRS
... Skip to content. skip to menu. Search Search. You are here: CNRS. Media. Paris, 20 January 2012 High-resolution mapping of the 3D organization of chromosomes In collaboration with researchers from the Weizmann Institute in Israel, a team from the Institut de Génétique Humaine CNRS has, for the first time, revealed the detailed three-dimensional architecture of chromosomes 1 : Giacomo Cavalli and his colleagues have achieved high-resolution 2 mapping of the different contacts that exist within and between chromosomes. They performed this feat using a new very high-throughput technique improved by the Montpellier team. This major research work should shed new light on the impact of 3D chromosome organization on genome 3 expression and on the onset of diseases such as cancer. It is published in the online version of the journal Cell of 19 January 2012. Researchers had suspected for years: individuals are more than the sum of their genes and therefore the architecture of their chromosomes could also be a key...
http://www2.cnrs.fr/en/1963.htm?theme1=7&debut=8
*  Psych Central - Scientists analyze chromosomes 2 and 4
... Home Conditions Quizzes Ask the Therapist Drugs Blogs News Research Resources Find Help Psychotherapy 101 Forums Support Groups Pro. NHGRI-supported researchers discover largest 'gene deserts'; find new clues to ancestral chromosome fusion event. The sequencing work on the chromosomes was carried out as part of the Human Genome Project at Washington University; Broad Institute of MIT, Cambridge, Mass.; Stanford DNA Sequencing and Technology Development Center, Stanford, Calif.; Wellcome Trust Sanger Institute, Hinxton, England; National Yang-Ming University, Taipei, Taiwan; Genoscope, Evry, France; Baylor College of Medicine, Houston; University of Washington Multimegabase Sequencing Center, Seattle; U.S. The new analysis confirmed the existence of 1,346 protein-coding genes on chromosome 2 and 796 protein-coding genes on chromosome 4. As part of their examination of chromosome 4, the researchers found what are believed to be the largest "gene deserts" yet discovered in the human genome sequence. These r...
http://psychcentral.com/news/archives/2005-04/nhgr-sac040605.html
*  Happy mapping
... in genetics happy mapping first proposed by paul h dear and peter r cook in is a method used to study the linkage between two or more dna sequences according to the it is mapping based on the analysis of approximately haploid dna samples using the polymerase chain reaction in genomics happy mapping can be applied to assess the synteny and orientation of various dna sequences across a particular genome the generation of a genomic map as with linkage mapping happy mapping relies on the differential probability of two or more dna sequences being separated in genetic mapping the probability of a recombination event between two genetic loci on the same chromosome is directly proportional to the distance between them happy mapping replaces recombination with fragmentation instead of relying on recombination to separate genetic loci the entire genome is fragmented for example by radiation or mechanical shearing if the dna is broken on a random basis the longer the distance between two dna sequences the higher t...
https://en.wikipedia.org/wiki/Happy_mapping
*  Mapping proteins on chromosome 19 -- ScienceDaily
... Your source for the latest research news. Mobile. Follow. Subscribe. Breaking News :. Rocks Show First Photosynthesis That Made Oxygen. Understanding Others' Thoughts Helps Kids to Lie. Extremely Light Storage Device as E-Car Battery. Birds Flew Over the Heads of Dinosaurs. Hog-Nose Rat Discovered. Foot Fossil: Evolutionary Messiness of Walking. Migrating Songbirds Can Be Tricked by Magnets. Fossils Intensify Mystery of Odd Toothy Mammal. Predator Survives, but Ecosystem Crashes. Restoring Vision With Stem Cells. Science News from research organizations. Mapping proteins on chromosome 19. Date: February 3, 2011 Source: Lund University Summary: Today, we know what all the genes on a person's 46 chromosomes look like, but it is only by studying the gene coding information linked to different proteins that we can gain knowledge that can lead to new drug developments. Researchers at one university have now taken on responsibility for coordinating the mapping of all the proteins of chromosome 19. Share:. Tota...
http://sciencedaily.com/releases/2011/02/110203081453.htm
*  JCVI: Chromosomal Distribution of 320 Genes from a Brain CDNA Library
jcvi chromosomal distribution of genes from a brain cdna library home about research sustainable lab publications education giving press careers contact listing about publications citation polymeropoulos m h xiao h sikela j m adams m venter j c merril c r chromosomal distribution of genes from a brain cdna library nat genet aug pubmed citation abstract we have determined the chromosomal assignment of brain expressed genes by studying the segregation of polymerase chain reaction pcr products in human rodent somatic cell hybrids and by genetically mapping polymorphic cdnas using the ceph centre d etude du polymophisme humaine reference pedigrees and database these mapped genes can function as markers on the physical map of the human genome as well as serve as candidate disease gene loci distribution of these genes to the human chromosomes correlates well with the gc content of the chromosomes however the distribution of these genes does not correlate well with the cytogenetic length of each chromosome back to l...
http://jcvi.org/cms/publications/listing/abstract/article/chromosomal-distribution-of-320-genes-from-a-brain-cdna-library/
*  ING1
ing ing inhibitor of growth protein is a protein that in humans is encoded by the ing gene function location on chromosome interactions references further reading external links function this gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis the encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein tp and is a component of the p signaling pathway reduced expression and rearrangement of this gene have been detected in various cancers multiple alternatively spliced transcript variants encoding distinct isoforms have been reported location on chromosome ing is located near the following genes on chromosome carkd carbohydrate kinase domain containing protein unknown function col a a subunit of type iv collagen rab potential regulator of connexin trafficking cars mitochondrial cystienyl trna synthetase interactions ing has been shown to interact with creb binding protein dmap hdac p pcna sap sin a smarca and smarcc references further...
https://en.wikipedia.org/wiki/ING1
*  Origins Map on Forge Island
... Search Older Posts on This Forum: Posts on Current Forum. View Thread. Origins Map on Forge Island. DOWNLOAD MAP HERE https://www.halowaypoint.com/en-us/players/sespider/halo4/fileshare #!/?section=GameMap&SearchDate=7&SortBy=2&view-select=Tile&startIndex=0&details=9e1ce458-54af-46ba-98a8-9552ef8decfb No images yet so I've substituted the images for this post. Map Name: Origins Layout This is a simple layout and VERY easy to navigate for Halo Vets. For every structure is based off of a classic structure/area from the Original Halo. http://hce.halomaps.org/images/files/lg/ACF330.jpg 2 The Reds get the Beach structure and the Covie Sniper Tower. http://cdn2.planetminecraft.com/files/resource media/screenshot/1239/2012-09-26 164529 3694760.jpg http://images.mocpages.com/user images/16468/1233808905m SPLASH.jpg 3 No spawns have been made for Gold and Purple bases yet. Purple base is the side structure also found on the Instillation 04 map. This structure can be seen at the bottom of this image: http://downlo...
http://carnage.bungie.org/haloforum/halo.forum.pl?read=1178162
*  Genatlas sheet
... selected genatlas references source genecards ncbi gene ensembl hgnc unigene nucleotide omim ucsc home page flash gene symbol krt p contributors npt updated hgnc name keratin pseudogene hgnc id flash gene dna rna expression protein disorder animal cell models location p physical location dna type pseudogene mapping cloned y linked n status provisional rna transcripts type expression protein associated disorders animal cell models...
http://genatlas.medecine.univ-paris5.fr/fiche.php?symbol=KRT18P40
*  Esri Mapping Center - Ask a Cartographer
... Ask A Cartographer Data Frame coordinate system different from data projection March 23 2009. 1 comment Categories: ArcGIS Methods, Map Elements I'm starting a new mapping project using our corporate data stored in UTM projection. The data frame for the map series will have a UTM projection but the data frame boundary will be geographical i.e., a 2-degree lat/lon system. Mapping Center Answer: What you're looking for is a grid we loosely shortened our internal term of "Map Grid" for the user interface for your data frame. In the help we called these reference systems*. There are three kinds of grids or reference systems: 1. Graticule what you're asking for, which displays latitude and longitude coordinates. 2 Measured Grid, which displays the coordinates of a coordinate system that you choose could be UTM, or here in the U.S., State Plane. To add a grid to your data frame, open the data frame's properties and click on the Grids tab. Click the New Grid button to launch the wizard default option; if you've...
http://mappingcenter.esri.com/index.cfm?fa=ask.answers&q=676
*  SPDYE1
spdye spdye multiple issues speedy homolog e xenopus laevis is a protein that in humans is encoded by the spdye gene function this gene is located at chromosome p which is close to the williams beuren syndrome chromosome region q evidence data start transcript exon combination af al rnaseq introns single sample supports all introns ers evidence data end references further reading category genes on human chromosome...
https://en.wikipedia.org/wiki/SPDYE1
*  MiR-212
mir mir multiple issues mir is a short non coding rna molecule microrna s function to regulate the expression levels of other genes by several mechanisms generally reducing protein levels through the cleavage of mrna s or the repression of their translation several targets for mir have been described including mediators of neurological development synaptic transmission inflammation and angiogenesis the rna molecule mir arises from the mir cluster located in the intron of a non coding gene on mouse chromosome heart pathology research in germany has found that mir and mir can inhibit cardiac pathology in rodents references category rna...
https://en.wikipedia.org/wiki/MiR-212
*  WSMethod
... All Classes. DETAIL: FIELD. Interface WSMethod. Method Summary. WSEndpoint. getEndpoint. java.util.Map java.lang.String,. Gets the map of WebParameter for the webserice method represented by instance of this type. invoke java.lang.Object args, WiseMapper mapper. Invokes this method with the provided arguments applying provided mapper. void setEndpoint WSEndpoint endpoint. Method Detail. InvocationResult invoke java.lang.Object args, WiseMapper mapper throws InvocationException , java.lang.IllegalArgumentException, MappingException. Invokes this method with the provided arguments applying provided mapper. Parameters: args - the arguments to call operation. It could be a generic Object to be passed to provided mapper. If mapper is null args must be a Map. This Map have to contain entries for all needed parameters, keys have to reflect operation parameter name as defined in wsdl. Keys which names are not defined in wsdls will be simply ignored. Implementation will take care values nullability will reflect "...
http://docs.jboss.org/wise/0.9/apiDocs/org/jboss/wise/core/client/WSMethod.html
*  #22799 y[1] w[67c23]; Mi{ET1}Liprin-gamma[MB00440]
y w mi et liprin gamma home browse search order fees accounts fly food supplies import permits bloomington stock report stock number plain text genotype y w mi et liprin gamma genotype with flybase links y w c mi et liprin γ mb chromosome s affected insertion chromosome s breakpoints or insertion site d r r ti date added to collection donor gene disruption project donor s source hugo j bellen comments flanking sequences map nucleotides apart but both ends show canonical minos sequences g d p may be segregating cyo k c flybase id fbst date report created top home...
http://flystocks.bio.indiana.edu/Reports/22799.html
*  RALGPS1
ralgps ralgps ral gef with ph domain and sh binding motif is a protein in humans that is encoded by the ralgps gene in chromosome references further reading category genes on human chromosome category human proteins...
https://en.wikipedia.org/wiki/RALGPS1

Biomarkers of aging: Biomarkers of aging are biomarkers that better predict functional capacity at a later age than chronological age. Stated another way, biomarkers of aging would give the true "biological age", which may be different from the chronological age.Microsatellite: A microsatellite is a tract of repetitive DNA in which certain DNA motifs (ranging in length from 2–5 base pairs) are repeated, typically 5-50 times. Microsatellites occur at thousands of locations in the human genome and they are notable for their high mutation rate and high diversity in the population.Chromosome regionsGenetic linkage: Genetic linkage is the tendency of alleles that are located close together on a chromosome to be inherited together during the meiosis phase of sexual reproduction. Genes whose loci are nearer to each other are less likely to be separated onto different chromatids during chromosomal crossover, and are therefore said to be genetically linked.Infinite alleles model: The infinite alleles model is a mathematical model for calculating genetic mutations. The Japanese geneticist Motoo Kimura and American geneticist James F.WGAViewer: WGAViewer is a bioinformatics software tool which is designed to visualize, annotate, and help interpret the results generated from a genome wide association study (GWAS). Alongside the P values of association, WGAViewer allows a researcher to visualize and consider other supporting evidence, such as the genomic context of the SNP, linkage disequilibrium (LD) with ungenotyped SNPs, gene expression database, and the evidence from other GWAS projects, when determining the potential importance of an individual SNP.Gene polymorphismGenetic variation: right|thumbCancer biomarkers: A cancer biomarker refers to a substance or process that is indicative of the presence of cancer in the body. A biomarker may be a molecule secreted by a tumor or a specific response of the body to the presence of cancer.DNA sequencer: A DNA sequencer is a scientific instrument used to automate the DNA sequencing process. Given a sample of DNA, a DNA sequencer is used to determine the order of the four bases: G (guanine), C (cytosine), A (adenine) and T (thymine).Thermal cyclerPanmixia: Panmixia (or panmixis) means random mating.King C and Stanfield W.Phenotype microarray: The phenotype microarray approach is a technology for high-throughput phenotyping of cells.Amplified fragment length polymorphismSymmetry element: A symmetry element is a point of reference about which symmetry operations can take place. In particular, symmetry elements can be centers of inversion, axes of rotation and mirror planes.Branching order of bacterial phyla (Gupta, 2001): There are several models of the Branching order of bacterial phyla, one of these was proposed in 2001 by Gupta based on conserved indels or protein, termed "protein signatures", an alternative approach to molecular phylogeny. Some problematic exceptions and conflicts are present to these conserved indels, however, they are in agreement with several groupings of classes and phyla.Coles PhillipsDisequilibrium (medicine): Disequilibrium}}Recombination (cosmology): In cosmology, recombination refers to the epoch at which charged electrons and protons first became bound to form electrically neutral hydrogen atoms.Note that the term recombination is a misnomer, considering that it represents the first time that electrically neutral hydrogen formed.Pedigree chart: A pedigree chart is a diagram that shows the occurrence and appearance or phenotypes of a particular gene or organism and its ancestors from one generation to the next,pedigree chart Genealogy Glossary - About.com, a part of The New York Times Company.Population stratification: Population stratification is the presence of a systematic difference in allele frequencies between subpopulations in a population possibly due to different ancestry, especially in the context of association studies. Population stratification is also referred to as population structure, in this context.Sequence clustering: In bioinformatics, sequence clustering algorithms attempt to group biological sequences that are somehow related. The sequences can be either of genomic, "transcriptomic" (ESTs) or protein origin.Haplogroup L0 (mtDNA)Nested case-control study: A nested case control (NCC) study is a variation of a case-control study in which only a subset of controls from the cohort are compared to the incident cases. In a case-cohort study, all incident cases in the cohort are compared to a random subset of participants who do not develop the disease of interest.Silent mutation: Silent mutations are mutations in DNA that do not significantly alter the phenotype of the organism in which they occur. Silent mutations can occur in non-coding regions (outside of genes or within introns), or they may occur within exons.Reseda odorata: Reseda odorata is a species of flowering plant in the reseda family known by many common names, including garden mignonette and common mignonette. It is probably native to the Mediterranean Basin, but it can sometimes be found growing in the wild as an introduced species in many parts of the world.Misattributed paternity: Misattributed paternity is the situation when a child’s putative father is not the child's biological father. Overall, the incidence of misattributed paternity ranges from about 1% to 2%, though it may be considerably higher in certain populations.Plant breedingHybrid inviability: Hybrid inviability is a post-zygotic barrier, which reduces a hybrid's capacity to mature into a healthy, fit adult.Hybrid inviability.United States regulation of point source water pollution: Point source water pollution comes from discrete conveyances and alters the chemical, biological, and physical characteristics of water. It is largely regulated by the Clean Water Act (CWA) of 1972.Inbreeding depression: Inbreeding depression is the reduced biological fitness in a given population as a result of inbreeding, or breeding of related individuals. Population biological fitness refers to its ability to survive and reproduce itself.Health geography: Health geography is the application of geographical information, perspectives, and methods to the study of health, disease, and health care.Clonal Selection Algorithm: In artificial immune systems, Clonal selection algorithms are a class of algorithms inspired by the clonal selection theory of acquired immunity that explains how B and T lymphocytes improve their response to antigens over time called affinity maturation. These algorithms focus on the Darwinian attributes of the theory where selection is inspired by the affinity of antigen-antibody interactions, reproduction is inspired by cell division, and variation is inspired by somatic hypermutation.Phylogeography: Phylogeography is the study of the historical processes that may be responsible for the contemporary geographic distributions of individuals. This is accomplished by considering the geographic distribution of individuals in light of the patterns associated with a gene genealogy.Decoding methods: In coding theory, decoding is the process of translating received messages into codewords of a given code. There have been many common methods of mapping messages to codewords.Hyperparameter: In Bayesian statistics, a hyperparameter is a parameter of a prior distribution; the term is used to distinguish them from parameters of the model for the underlying system under analysis.RAPD: RAPD (pronounced "rapid") stands for 'Random Amplified Polymorphic DNA'. It is a type of PCR reaction, but the segments of DNA that are amplified are random.Multiple Loci VNTR Analysis: Multiple Loci VNTR Analysis (MLVA ) is a method employed for the genetic analysis of particular microorganisms, such as pathogenic bacteria, that takes advantage of the polymorphism of tandemly repeated DNA sequences. A "VNTR" is a "variable-number tandem repeat".Tandem repeat: Tandem repeats occur in DNA when a pattern of one or more nucleotides is repeated and the repetitions are directly adjacent to each other. Several protein domains also form tandem repeats within their amino acid primary structure, such as Armadillo repeats.Beef cattle: Beef cattle are cattle raised for meat production (as distinguished from dairy cattle, used for milk production). The meat of adult cattle is known as beef.List of sequenced eukaryotic genomesIndian blood group system: The Indian blood group system (In) is a classification of blood based on the presence or absence of inherited antigens that reside within the CD44 molecule that is expressed on the surface of blood cells. It is named so because 4% of the population in India possess it.Inverse probability weighting: Inverse probability weighting is a statistical technique for calculating statistics standardized to a population different from that in which the data was collected. Study designs with a disparate sampling population and population of target inference (target population) are common in application.Hereditary Disease Foundation: The Hereditary Disease Foundation (HDF) aims to cure genetic disorders by supporting basic biomedical research.California Wolf Center: California Wolf Center is a 501(c)3 nonprofit located 50 miles east of San Diego, near the town of Julian, California. It is a one-of-a-kind, conservation, education, and research center dedicated to wolf recovery in the wild.Circular bacterial chromosome: A circular bacterial chromosome is a bacterial chromosome in the form of a molecule of circular DNA. Unlike the linear DNA of most eukaryotes, typical bacterial chromosomes are circular.Iridogoniodysgenesis, dominant type: Iridogoniodysgenesis, dominant type (type 1, IRID1) refers to a spectrum of diseases characterized by malformations of the irido-corneal angle of the anterior chamber of the eye. Iridogoniodysgenesis is the result of abnormal migration or terminal induction of neural crest cells.Interval boundary element method: Interval boundary element method is classical boundary element method with the interval parameters.
DNA condensation: DNA condensation refers to the process of compacting DNA molecules in vitro or in vivo. Mechanistic details of DNA packing are essential for its functioning in the process of gene regulation in living systems.Gene signature: A gene signature is a group of genes in a cell whose combined expression patternItadani H, Mizuarai S, Kotani H. Can systems biology understand pathway activation?Marker vaccine: A marker vaccine allows for immunological differentiation of infected from vaccinated individuals, and is also referred to as a DIVA vaccine in veterinary medicine (differentiation of infected from vaccinated animals). In practical terms, this is most often achieved by omitting an immunogenic antigen present in the pathogen being vaccinated against, thus creating a negative marker of vaccination.Assay sensitivity: Assay sensitivity is a property of a clinical trial defined as the ability of a trial to distinguish an effective treatment from a less effective or ineffective intervention. Without assay sensitivity, a trial is not internally valid and is not capable of comparing the efficacy of two interventions.Molecular evolution: Molecular evolution is a change in the sequence composition of cellular molecules such as DNA, RNA, and proteins across generations. The field of molecular evolution uses principles of evolutionary biology and population genetics to explain patterns in these changes.Mac OS X Server 1.0Alkaliflexus: Alkaliflexus is a genus in the phylum Bacteroidetes (Bacteria).Ontario Genomics Institute: The Ontario Genomics Institute (OGI) is a not-for-profit organization that manages cutting-edge genomics research projects and platforms.The Ontario Genomics Institute OGI also helps scientists find paths to the marketplace for their discoveries and the products to which they lead, and it works through diverse outreach and educational activities to raise awareness and facilitate informed public dialogue about genomics and its social impacts.QRISK: QRISK2 (the most recent version of QRISK) is a prediction algorithm for cardiovascular disease (CVD) that uses traditional risk factors (age, systolic blood pressure, smoking status and ratio of total serum cholesterol to high-density lipoprotein cholesterol) together with body mass index, ethnicity, measures of deprivation, family history, chronic kidney disease, rheumatoid arthritis, atrial fibrillation, diabetes mellitus, and antihypertensive treatment.Selection (relational algebra): In relational algebra, a selection (sometimes called a restriction to avoid confusion with SQL's use of SELECT) is a unary operation written as

(1/12529) 11q23.1 and 11q25-qter YACs suppress tumour growth in vivo.

Frequent allelic deletion at chromosome 11q22-q23.1 has been described in breast cancer and a number of other malignancies, suggesting putative tumour suppressor gene(s) within the approximately 8 Mb deleted region. In addition, we recently described another locus, at the 11q25-qter region, frequently deleted in breast cancer, suggesting additional tumour suppressor gene(s) in this approximately 2 Mb deleted region. An 11q YAC contig was accessed and three YACs, one containing the candidate gene ATM at 11q23.1, and two contiguous YACs (overlapping for approximately 400-600 kb) overlying most of the 11q25 deleted region, were retrofitted with a G418 resistance marker and transfected into murine A9 fibrosarcoma cells. Selected A9 transfectant clones (and control untransfected and 'irrelevant' alphoid YAC transfectant A9 clones) were assayed for in vivo tumorigenicity in athymic female Balb c-nu/nu mice. All the 11q YAC transfectant clones demonstrated significant tumour suppression compared to the control untransfected and 'irrelevant' YAC transfected A9 cells. These results define two discrete tumour suppressor loci on chromosome 11q by functional complementation, one to a approximately 1.2 Mb region on 11q23.1 (containing the ATM locus) and another to a approximately 400-600 kb subterminal region on 11q25-qter.  (+info)

(2/12529) Superimposed histologic and genetic mapping of chromosome 9 in progression of human urinary bladder neoplasia: implications for a genetic model of multistep urothelial carcinogenesis and early detection of urinary bladder cancer.

The evolution of alterations on chromosome 9, including the putative tumor suppressor genes mapped to the 9p21-22 region (the MTS genes), was studied in relation to the progression of human urinary bladder neoplasia by using whole organ superimposed histologic and genetic mapping in cystectomy specimens and was verified in urinary bladder tumors of various pathogenetic subsets with longterm follow-up. The applicability of chromosome 9 allelic losses as non-invasive markers of urothelial neoplasia was tested on voided urine and/or bladder washings of patients with urinary bladder cancer. Although sequential multiple hits in the MTS locus were documented in the development of intraurothelial precursor lesions, the MTS genes do not seem to represent a major target for p21-23 deletions in bladder cancer. Two additional tumor suppressor genes involved in bladder neoplasia located distally and proximally to the MTS locus within p22-23 and p11-13 regions respectively were identified. Several distinct putative tumor suppressor gene loci within the q12-13, q21-22, and q34 regions were identified on the q arm. In particular, the pericentromeric q12-13 area may contain the critical tumor suppressor gene or genes for the development of early urothelial neoplasia. Allelic losses of chromosome 9 were associated with expansion of the abnormal urothelial clone which frequently involved large areas of urinary bladder mucosa. These losses could be found in a high proportion of urothelial tumors and in voided urine or bladder washing samples of nearly all patients with urinary bladder carcinoma.  (+info)

(3/12529) Multiple target sites of allelic imbalance on chromosome 17 in Barrett's oesophageal cancer.

Twelve Barrett's adenocarcinomas have been analysed for the occurrence of allelic imbalance (LOH) on chromosome 17 using 41 microsatellite markers. This study provides evidence for 13 minimal regions of LOH, six on 17p and seven on 17q. Four of these centre in the vicinity of the known tumour suppressor genes (TSGs) TP53 (17p13.1), NFI (17q11.2), BRCA1 (17q21.1), and a putative TSG (17p13.3). The tumours all displayed relatively small regions of LOH (1-10 cM), and in several tumours extensive regions of LOH were detected. One tumour displayed only two very small regions of LOH; 17p11.2 and 17p13.1. The frequency of allelic imbalance has been calculated based on the LOH encompassing only one minimal region, and based on all the LOH observations. By both evaluations the highest LOH frequencies were found for regions II (p53), III (17p13.1 centromeric to p53), IV (17p12), V (17p11.2) and VII (NF1, 17q11.2). Our data supports the existence of multiple TSGs on chromosome 17 and challenges the view that p53 is the sole target of LOH on 17p in Barrett's adenocarcinoma.  (+info)

(4/12529) Correlation between the status of the p53 gene and survival in patients with stage I non-small cell lung carcinoma.

The association of p53 abnormalities with the prognosis of patients with non-small cell lung carcinoma (NSCLC) has been extensively investigated to date, however, this association is still controversial. Therefore, we investigated the prognostic significance of p53 mutations through exons 2 to 11 and p53 protein expression in 103 cases of stage I NSCLC. p53 mutations were detected in 49 of 103 (48%) tumors. Two separate mutations were detected in four tumors giving a total of 53 unique mutations in 49 tumors. Ten (19%) of mutations occurred outside exons 5-8. Positive immunohistochemical staining of p53 protein was detected in 41 of 103 (40%) tumors. The concordance rate between mutations and protein overexpression was only 69%. p53 mutations, but not expression, were significantly associated with a shortened survival of patients (P<0.001). Furthermore, we investigated the correlation between the types of p53 mutations and prognosis. p53 missense mutations rather than null mutations were associated with poor prognosis (P < 0.001 in missense mutations and P=0.243 in null mutations). These results indicated that p53 mutations, in particular missense mutations, rather than p53 expression could be a useful molecular marker for the prognosis of patients with surgically resected stage I NSCLC.  (+info)

(5/12529) p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent.

p73, a novel p53 family member, is a recently identified candidate neuroblastoma (NBL) suppressor gene mapped at chromosome 1p36.33 and was found to inhibit growth and induce apoptosis in cell lines. To test the hypothesis that p73 is a NBL suppressor gene, we analysed the p73 gene in primary human NBLs. Loss of heterozygosity (LOH) for p73 was observed in 19% (28/151) of informative cases which included 92 mass-screening (MS) tumors. The high frequency of p73 LOH was significantly associated with sporadic NBLs (9% vs 34%, P<0.001), N-myc amplification (10% vs 71%, P<0.001), and advanced stage (14% vs 28%, P<0.05). Both p73alpha and p73beta transcripts were detectable in only 46 of 134 (34%) NBLs at low levels by RT-PCR methods, while they were easily detectable in most breast cancers and colorectal cancers under the same conditions. They found no correlation between p73 LOH and its expression levels (P>0.1). We found two mutations out of 140 NBLs, one somatic and one germline, which result in amino acid substitutions in the C-terminal region of p73 which may affect transactivation functions, though, in the same tumor samples, no mutation of the p53 gene was observed as reported previously. These results suggest that allelic loss of the p73 gene may be a later event in NBL tumorigenesis. However, p73 is infrequently mutated in primary NBLs and may hardly function as a tumor suppressor in a classic Knudson's manner.  (+info)

(6/12529) High polymorphism level of genomic sequences flanking insertion sites of human endogenous retroviral long terminal repeats.

The polymorphism at the multitude of loci adjacent to human endogenous retrovirus long terminal repeats (LTRs) was analyzed by a technique for whole genome differential display based on the PCR suppression effect that provides selective amplification and display of genomic sequences flanking interspersed repeated elements. This strategy is simple, target-specific, requires a small amount of DNA and provides reproducible and highly informative data. The average frequency of polymorphism observed in the vicinity of the LTR insertion sites was found to be about 12%. The high incidence of polymorphism within the LTR flanks together with the frequent location of LTRs near genes makes the LTR loci a useful source of polymorphic markers for gene mapping.  (+info)

(7/12529) Structure of cag pathogenicity island in Japanese Helicobacter pylori isolates.

BACKGROUND: cag pathogenicity island (PAI) is reported to be a major virulence factor of Helicobacter pylori. AIM: To characterise cagA and the cag PAI in Japanese H pylori strains. METHODS: H pylori isolates from Japanese patients were evaluated for CagA by immunoblot, for cagA transcription by northern blot, and for cagA and 13 other cag PAI genes by Southern blot. cagA negative strains from Western countries were also studied. Induction of interleukin-8 secretion from gastric epithelial cells was also investigated. RESULTS: All Japanese strains retained cagA. Fifty nine of 63 (94%) strains had all the cag PAI genes. In the remaining four, cag PAI was partially deleted, lacking cagA transcripts and not producing CagA protein. Details of the PAI of these strains were checked; three lacked cagB to cagQ (cagI) and continuously cagS to cag13 (cagII), and the remaining one lacked cagB to cag8. Western cagA negative strains completely lacked cag PAI including cagA. Nucleotide sequence analysis in one strain in which the cag PAI was partially deleted showed that the partial deletion contained 25 kb of cag PAI and the cagA promoter. Interleukin-8 induction was lower with the cag PAI partial deletion strains than with the intact ones. All Japanese cag PAI deleted strains were derived from patients with non-ulcer dyspepsia, whereas 41 of 59 (70%) CagA-producing strains were from patients with peptic ulcers or gastric cancer (p<0.05). CONCLUSIONS: Most Japanese H pylori strains had the intact cag PAI. However, some lacked most of the cag PAI in spite of the presence of cagA. Thus the presence of the cagA gene is not an invariable marker of cag PAI related virulence in Japanese strains.  (+info)

(8/12529) Screening for mutations of the cationic trypsinogen gene: are they of relevance in chronic alcoholic pancreatitis?

BACKGROUND: In hereditary pancreatitis mutations of exons 2 (N21I) and 3 (R117H) of the cationic trypsinogen gene have been described. AIMS: To investigate whether the same mutations can also be found in patients with chronic alcoholic pancreatitis. METHODS: Leucocyte DNA was prepared from 23 patients with chronic alcoholic pancreatitis, 21 with alcoholic liver cirrhosis, 34 individuals from seven independent families with hereditary pancreatitis, and 15 healthy controls. DNA was also obtained from pancreatic tissue (n=7) and from pancreatic juice (n=5) of patients suffering from chronic alcoholic pancreatitis. R117H was detected by restriction digestion with Afl III. N21I was identified by an allele specific polymerase chain reaction (PCR). RESULTS: R117H was detected in four families with hereditary pancreatitis. The N21I mutation was identified in three families. All mutations were confirmed by sequencing of the corresponding DNAs. In patients with chronic alcoholic pancreatitis neither the exon 2 nor exon 3 mutations were present in blood leucocytes, pancreatic juice, or pancreatic tissue. DNA of the patients with alcoholic liver cirrhosis as well as all controls was of wild type. CONCLUSIONS: The allele specific PCR may be used to screen for the N21I mutation of cationic trypsinogen. Both trypsinogen mutations were found in hereditary pancreatitis but do not seem to be major pathogenic factors in chronic alcoholic pancreatitis.  (+info)


What does it mean to have 3 out of 6 genetics markers when getting test results for being a kidney donor?


I got tested for being a kidney donor and they said I was a negative cross match and that I have 3 out of 6 genetic markers, what does that mean? Is that good?
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That doesn't sound good...disappointing to hear you may not be able to donate.  You have only 3 out 6 matching genetic characteristics--a 50% correct match.  If you matched on 6 out of 6 "markers" it would be a perfect match--likely only with full-blood siblings. 
Here's an excerpt from a web page  (reference below) that discusses the tissue typing question you ask. 

After the blood types match, doctors then check tissue compatibility....

     "A second test of compatibility looks at the match of human leukocyte antigens (HLA). There are many different kinds of antigens, but there are three categories assessed for kidney donation, designated HLA-A, HLA-B, and HLA-DR. You inherit one set of these three antigens from each parent giving you a total of six HLAs.

    Your antigens are determined by drawing blood and testing it. A similar test is run for the recipient, and the antigens are compared. The closer the match the better because the recipient is less likely to reject the donated organ. You might hear of a "six-of-six" match (all donor and recipient antigens match) or a "half match" (three of the six antigens are the same) or a "zero match" (none of the antigens matches).

There was a time when this type of tissue compatibility was important. However, the development of more effective anti-rejection drugs has reduced the importance of the HLA match. In fact, some transplant teams ignore tissue typing. Therefore, even if your degree of matching with the donor is relatively low, you may still be considered for donation."

So that makes it sound like there still is some hope... but  
since the doctors said you were a negative cross match I would follow up with them directly...your kidney might be rejected by the doner or cause other health problems for him or her...or it might still work, depending on how desperate the situation is. Call and ask the doctors this question since every donation is different.

Good luck!

Amy

Amy


what is the genetic marker that dictates penis size?


what is the genetic marker that dictates penis size?
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if your dad's will reach the back of your throat, your's will be huge!


White parents give birth to black baby?


I heard this phenomenon and i know it's possible, I discovered some countries in europe have genetic markers shared among north africa, ( most frequent of these genes is found among somalians) but i have a question, who were these people that gave birth to a black baby,i heard it did happen but who was it?..... Give me a link to the article that talks about it .
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http://www.afroromance.com/blog/white-mother-white-father-black-baby.htm


What are the options for individual genetic testing?


I heard that there are some companies that do genetic testing and determine susceptibility to various diseases.

For example Market America has "Gene SNP" program when you send your saliva in and get report with recommendations and some food supplements.

How reliable such tests are?
Which company's tests have the widest disease coverage?
What is the reasonable price to pay for such service?
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I wouldn't waste your money on this type of test.  This type of science is not advanced enough to give you much in the way of useful information.  Even if a company can test for 100 different diseases, that doesn't mean that the genetic markers they test for account for much of your overall disease risk.  Most common diseases are caused by a combination of many genetic and environmental factors, most of which we probably have not yet discovered.  Additionally, we don't really have enough data about these types of genetic variants for doctors to know what to do with the results.  Your doctors probably wouldn't (and really shouldn't) change your medical management, regardless of what your results found.


Can someone give me a rare genetic disorder to write a paper on?


I need to write a paper on a genetic disorder. It has to be something not in my biology book so that's why I want a rare one. Can anyone list some? Perhaps some interesting ones? Thanks.
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MY TOP 3 FAVORITE GENETIC DISORDERS I LEARNED ABOUT IN MED SCHOOL:
1. Alkaptonuria- when your pee turns black when exposed to air
2. Huntington's- when people have abnormal jerky body movements
3. Pseudoxanthoma elasticum- when a 20 year old person has the lose  skin of an 80 year old

Good Luck!


What is a lethal genetic disease that starts in teen years?


I'm writing a story where the main character is in her mid-teen years. She is diagnosed with a genetic disease that will kill her in 2-3 years. I need to know of a genetic disease/mutation that would begin to show symptoms at 13-17 years and results in death a few years later. Thank you for any help!
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Diseases that are diagnosed later in life generally aren't genetic. If you want to change your story a little she could have cystic fibrosis (CF) but if she wasn't diagnosed when she was a baby it would be a really mild case and it wouldn't kill her in 2-3 years.


How many genetic diseases can be tested for?


I'm wondering how many genetic tests they are able to test for. I know there are already over 1300 different tests available, but how many diseases are there that can be tested for?
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many genetic diseases can be tested. Here's the situation. I have cystic fibrosis. There are over 1600 DNA mutations for this illness, any of them can be a diagnosis of this illness. this is just chrome 7. there can be other mutations to chrome 7 for other illnesses, ie candida predisposition, something like that. most hosp/clinics will initially test for the most common mutations and are limited to the 32 most common mutations, pt can fall outside that area. I did. the 23/32 most common were negative. further testing proved that. It was expensive, $1150. out of pocket. took about a month.



For amniotic screening, many genetic diseases can be tested, most common are tested for unless known family hx and specific testing is requested. Ambry genetics does mostly cystic fibrosis.


What kind of markers do they use on the chalkboards at starbucks or other coffee places?


You know the beautiful markers they use on the boards to put the menus and coffee specials up....what are they?
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They're called "Chalk Ink" markers. That's the brand - you can get them at Michael's Craft stores.