The fluctuation of the ALLELE FREQUENCY from one generation to the next.
Differential and non-random reproduction of different genotypes, operating to alter the gene frequencies within a population.
The discipline studying genetic composition of populations and effects of factors such as GENETIC SELECTION, population size, MUTATION, migration, and GENETIC DRIFT on the frequencies of various GENOTYPES and PHENOTYPES using a variety of GENETIC TECHNIQUES.
Genotypic differences observed among individuals in a population.
Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.
The proportion of one particular in the total of all ALLELES for one genetic locus in a breeding POPULATION.
The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.
The change in gene frequency in a population due to migration of gametes or individuals (ANIMAL MIGRATION) across population barriers. In contrast, in GENETIC DRIFT the cause of gene frequency changes are not a result of population or gamete movement.
The relationships of groups of organisms as reflected by their genetic makeup.
The science dealing with the earth and its life, especially the description of land, sea, and air and the distribution of plant and animal life, including humanity and human industries with reference to the mutual relations of these elements. (From Webster, 3d ed)
A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs).
Number of individuals in a population relative to space.
A phenomenon that is observed when a small subgroup of a larger POPULATION establishes itself as a separate and isolated entity. The subgroup's GENE POOL carries only a fraction of the genetic diversity of the parental population resulting in an increased frequency of certain diseases in the subgroup, especially those diseases known to be autosomal recessive.
Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.
Double-stranded DNA of MITOCHONDRIA. In eukaryotes, the mitochondrial GENOME is circular and codes for ribosomal RNAs, transfer RNAs, and about 10 proteins.
The biological objects that contain genetic information and that are involved in transmitting genetically encoded traits from one organism to another.
The genetic constitution of individuals with respect to one member of a pair of allelic genes, or sets of genes that are closely linked and tend to be inherited together such as those of the MAJOR HISTOCOMPATIBILITY COMPLEX.
An animal or plant species in danger of extinction. Causes can include human activity, changing climate, or change in predator/prey ratios.
The pattern of any process, or the interrelationship of phenomena, which affects growth or change within a population.
The relative amount by which the average fitness of a POPULATION is lowered, due to the presence of GENES that decrease survival, compared to the GENOTYPE with maximum or optimal fitness. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
An ethnic group with historical ties to the land of ISRAEL and the religion of JUDAISM.
The comparative science dealing with the physical characteristics of humans as related to their origin, evolution, and development in the total environment.
The detection of RESTRICTION FRAGMENT LENGTH POLYMORPHISMS by selective PCR amplification of restriction fragments derived from genomic DNA followed by electrophoretic analysis of the amplified restriction fragments.
The capability of an organism to survive and reproduce. The phenotypic expression of the genotype in a particular environment determines how genetically fit an organism will be.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
The mating of plants or non-human animals which are closely related genetically.
The functions and activities of living organisms that support life in single- or multi-cellular organisms from their origin through the progression of life.
Nonrandom association of linked genes. This is the tendency of the alleles of two separate but already linked loci to be found together more frequently than would be expected by chance alone.
The total genetic information possessed by the reproductive members of a POPULATION of sexually reproducing organisms.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
A genus of gram-negative bacteria which are obligately intracellular endosymbionts of APHIDS. The bacteria are found within specialized cells in the aphid body cavity.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
The splitting of an ancestral species into daughter species that coexist in time (King, Dictionary of Genetics, 6th ed). Causal factors may include geographic isolation, HABITAT geometry, migration, REPRODUCTIVE ISOLATION, random GENETIC DRIFT and MUTATION.
Changes in biological features that help an organism cope with its ENVIRONMENT. These changes include physiological (ADAPTATION, PHYSIOLOGICAL), phenotypic and genetic changes.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A plant species of the genus PINUS that contains isocupressic acid.
A functional system which includes the organisms of a natural community together with their environment. (McGraw Hill Dictionary of Scientific and Technical Terms, 4th ed)
Computer-based representation of physical systems and phenomena such as chemical processes.
Techniques which study entities using their topological, geometric, or geographic properties and include the dimension of time in the analysis.
The total number of individuals inhabiting a particular region or area.
Individual members of South American ethnic groups with historic ancestral origins in Asia.
An individual having different alleles at one or more loci regarding a specific character.
Functions constructed from a statistical model and a set of observed data which give the probability of that data for various values of the unknown model parameters. Those parameter values that maximize the probability are the maximum likelihood estimates of the parameters.
A large family of fruit flies in the order DIPTERA, comprising over 4,500 species in about 100 genera. They have patterned wings and brightly colored bodies and are found predominantly in the tropical latitudes.
Family of the suborder HAPLORHINI (Anthropoidea) comprising bipedal primate MAMMALS. It includes modern man (HOMO SAPIENS) and the great apes: gorillas (GORILLA GORILLA), chimpanzees (PAN PANISCUS and PAN TROGLODYTES), and orangutans (PONGO PYGMAEUS).
The process of leaving one's country to establish residence in a foreign country.
Processes that incorporate some element of randomness, used particularly to refer to a time series of random variables.
The total process by which organisms produce offspring. (Stedman, 25th ed)
A phenotypically recognizable genetic trait which can be used to identify a genetic locus, a linkage group, or a recombination event.
A theorem in probability theory named for Thomas Bayes (1702-1761). In epidemiology, it is used to obtain the probability of disease in a group of people with some characteristic on the basis of the overall rate of that disease and of the likelihood of that characteristic in healthy and diseased individuals. The most familiar application is in clinical decision analysis where it is used for estimating the probability of a particular diagnosis given the appearance of some symptoms or test result.
A field of study concerned with the principles and processes governing the geographic distributions of genealogical lineages, especially those within and among closely related species. (Avise, J.C., Phylogeography: The History and Formation of Species. Harvard University Press, 2000)
I'm afraid there seems to be a misunderstanding - "Africa" is not a medical term and does not have a medical definition. Africa is the world's second-largest and second-most populous continent, consisting of 54 countries with diverse cultures, peoples, languages, and landscapes. If you have any questions related to medical topics or definitions, I would be happy to help answer those for you!
Specific regions that are mapped within a GENOME. Genetic loci are usually identified with a shorthand notation that indicates the chromosome number and the position of a specific band along the P or Q arm of the chromosome where they are found. For example the locus 6p21 is found within band 21 of the P-arm of CHROMOSOME 6. Many well known genetic loci are also known by common names that are associated with a genetic function or HEREDITARY DISEASE.
The human male sex chromosome, being the differential sex chromosome carried by half the male gametes and none of the female gametes in humans.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Periodic movements of animals in response to seasonal changes or reproductive instinct. Hormonal changes are the trigger in at least some animals. Most migrations are made for reasons of climatic change, feeding, or breeding.
The production of offspring by selective mating or HYBRIDIZATION, GENETIC in animals or plants.
Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.
A family (Aphididae) of small insects, in the suborder Sternorrhyncha, that suck the juices of plants. Important genera include Schizaphis and Myzus. The latter is known to carry more than 100 virus diseases between plants.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Statistical interpretation and description of a population with reference to distribution, composition, or structure.
The non-genetic biological changes of an organism in response to challenges in its ENVIRONMENT.
The homologous chromosomes that are dissimilar in the heterogametic sex. There are the X CHROMOSOME, the Y CHROMOSOME, and the W, Z chromosomes (in animals in which the female is the heterogametic sex (the silkworm moth Bombyx mori, for example)). In such cases the W chromosome is the female-determining and the male is ZZ. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
The deductive study of shape, quantity, and dependence. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.
I'm sorry for any confusion, but 'Europe' is a geographical continent and not a medical term; therefore, it doesn't have a medical definition.
The study of chance processes or the relative frequency characterizing a chance process.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
One of the BIOLOGICAL SCIENCE DISCIPLINES concerned with the origin, structure, development, growth, function, genetics, and reproduction of animals, plants, and microorganisms.

Small genome of Candidatus Blochmannia, the bacterial endosymbiont of Camponotus, implies irreversible specialization to an intracellular lifestyle. (1/553)

Blochmannia (Candidatus Blochmannia gen. nov.) is the primary bacterial endosymbiont of the ant genus CAMPONOTUS: Like other obligate endosymbionts of insects, Blochmannia occurs exclusively within eukaryotic cells and has experienced long-term vertical transmission through host lineages. In this study, PFGE was used to estimate the genome size of Blochmannia as approximately 800 kb, which is significantly smaller than its free-living relatives in the enterobacteria. This small genome implies that Blochmannia has deleted most of the genetic machinery of related free-living bacteria. Due to restricted gene exchange in obligate endosymbionts, the substantial gene loss in Blochmannia and other insect mutualists may reflect irreversible specialization to a host cellular environment.  (+info)

Multileveled selection on plasmid replication. (2/553)

The replication control genes of bacterial plasmids face selection at two conflicting levels. Plasmid copies that systematically overreplicate relative to their cell mates have a higher chance of fixing in descendant cells, but these cells typically have a lower chance of fixing in the population. Apart from identifying the conflict, this mathematical discussion characterizes the efficiency of the selection levels and suggests how they drive the evolution of kinetic mechanisms. In particular it is hypothesized that: (1) tighter replication control is more vulnerable to selfishness; (2) cis-acting replication activators are relics of a conflict where a plasmid outreplicated its intracellular competitors by monopolizing activators; (3) high-copy plasmids with sloppy replication control arise because intracellular selection favors overreplication, thereby relieving intercellular selection for lower loss rates; (4) the excessive synthesis of cis-acting replication activators and trans-acting inhibitors is the result of an arms race between cis selfishness and trans retaliations; (5) site-specific recombination of plasmid dimers is equivalent to self-policing; and (6) plasmids modify their horizontal transfer to spread without promoting selfishness. It is also discussed how replication control may be subject to a third level of selection acting on the entire population of plasmid-containing cells.  (+info)

Microsatellite diversities and gene flow in the tsetse fly, Glossina morsitans s.l. (3/553)

Tsetse flies occupy discontinuous habitats and gene flow among them needs to be investigated in anticipation of area-wide control programs. Genetic diversities were estimated at six microsatellite loci in seven Glossina morsitans submorsitans Newstead (Diptera: Glossinidae) populations and five microsatellite loci in six G. m. morsitans Westwood populations. Nei's unbiased diversities were 0.808 and 76 alleles in G. m. submorsitans and 0.727 and 55 alleles in G. m. morsitans. Diversities were less in three laboratory cultures. Matings were random within populations. Populations were highly differentiated genetically. Populations were strongly subdivided, as indicated by fixation indices (F(ST)) of 0.18 in G. m. morsitans and 0.17 in G. m. submorsitans. 35% of the genetic variance in G. m. submorsitans was attributed to differences between populations from The Gambia and Ethiopia. All available genetic evidence suggests that genetic drift is much greater than gene flow among G. morsitans s.l. populations.  (+info)

Detecting genomic features under weak selective pressure: the example of codon usage in animals and plants. (4/553)

Large scale experiments of gene inactivation in yeast have shown that 50% of genes have no detectable impact on the phenotype, and similar observations have been made in other model organisms. This apparent paradox is probably due to the fact that many genes only have a marginal contribution to the fitness of organisms. Because of the size of populations and the number of generations that can be studied in laboratories, experimental approaches only permit to detect functional elements that have a strong phenotypic impact. Comparative sequence analysis can help to solve this problem: the analysis of sequences evolution permits to detect the action of selection, and hence to reveal functional features of genomes. This approach will be illustrated by the study of synonymous codon usage in animals and plants.  (+info)

Conflict between nuclear and mitochondrial DNA phylogenies of a recent species radiation: what mtDNA reveals and conceals about modes of speciation in Hawaiian crickets. (5/553)

It has been asserted that recent mtDNA phylogenies support the plausibility of sympatric speciation, long considered a controversial mechanism of the origin of species. If such inferences are reliable, mtDNA phylogenies should be congruent with phylogenies based on other data. In previous work, a mtDNA phylogeny suggested that diversification of the Hawaiian cricket genus Laupala was initiated by single invasions into each of several Hawaiian islands, followed by multiple sympatric divergences within each island. In contrast, a systematic hypothesis based on morphology argues that speciation in Laupala has occurred primarily in allopatry, with two independent species radiations diversifying across the archipelago. In this study, I analyze nuclear DNA (nDNA) sequences from Laupala to compare with sequences from the mtDNA. The nDNA phylogeny corroborates the hypothesis of allopatric divergence and multiple invasions, and when compared with mtDNA patterns, suggests that interspecific hybridization is a persistent feature of the history of Laupala. The discrepancy between mtDNA and nDNA phylogenies reveals that speciation histories based on mtDNA alone can be extensively misleading.  (+info)

Near-neutrality in evolution of genes and gene regulation. (6/553)

The nearly neutral theory contends that the interaction of drift and selection is important and occurs at various levels, including synonymous and nonsynonymous substitutions in protein coding regions and sequence turnover of regulatory elements. Recent progress of the theory is reviewed, and the interaction between drift and selection is suggested to differ at these different levels. Weak selective force on synonymous changes is stable, whereas its consequence on nonsynonymous changes depends on environmental factors. Selection on differentiation of regulatory elements is even more dependent on environmental factors than on amino acid changes. Of particular significance is the role of drift in the evolution of gene regulation that directly participates in morphological evolution. The range of near neutrality depends on the effective size of the population that is influenced by selected linked loci. In addition to the effective population size, molecular chaperones such as heat shock protein 90 have significant effects on the range of near neutrality.  (+info)

Genetic structure of human populations. (7/553)

We studied human population structure using genotypes at 377 autosomal microsatellite loci in 1056 individuals from 52 populations. Within-population differences among individuals account for 93 to 95% of genetic variation; differences among major groups constitute only 3 to 5%. Nevertheless, without using prior information about the origins of individuals, we identified six main genetic clusters, five of which correspond to major geographic regions, and subclusters that often correspond to individual populations. General agreement of genetic and predefined populations suggests that self-reported ancestry can facilitate assessments of epidemiological risks but does not obviate the need to use genetic information in genetic association studies.  (+info)

Noisy clues to the origin of life. (8/553)

The origin of stable self-replicating molecules represents a fundamental obstacle to the origin of life. The low fidelity of primordial replicators places restrictions on the quantity of information encoded in a primitive nucleic acid alphabet. Further difficulties for the origin of life are the role of drift in small primordial populations, reducing the rate of fixation of superior replicators, and the hostile conditions increasing developmental noise. Thus, mutation, noise and drift are three different stochastic effects that are assumed to make the evolution of life improbable. Here we show, to the contrary, how noise present in hostile early environments can increase the probability of faithful replication, by amplifying selection in finite populations. Noise has negative consequences in infinite populations, whereas in finite populations, we observe a synergistic interaction among noise sources. Hence, two factors formerly considered inimical to the origin of life-developmental noise and drift in small populations-can in combination give rise to conditions favourable to robust replication.  (+info)

Genetic drift is a mechanism of evolution that causes changes in the frequency of alleles (versions of a gene) in a population due to random sampling. It occurs when the sample size is small, and therefore the genetic variation may not reflect the population's genetic diversity as a whole. This can lead to the loss of certain alleles and an increase in others, even if those alleles are not necessarily advantageous or disadvantageous. Genetic drift can be a significant factor in shaping the genetic composition of small, isolated populations and can result in the fixation (complete loss or gain) of particular alleles over time.

Genetic selection, also known as natural selection, is a fundamental mechanism of evolution. It refers to the process by which certain heritable traits become more or less common in a population over successive generations due to differential reproduction of organisms with those traits.

In genetic selection, traits that increase an individual's fitness (its ability to survive and reproduce) are more likely to be passed on to the next generation, while traits that decrease fitness are less likely to be passed on. This results in a gradual change in the distribution of traits within a population over time, leading to adaptation to the environment and potentially speciation.

Genetic selection can occur through various mechanisms, including viability selection (differential survival), fecundity selection (differences in reproductive success), and sexual selection (choices made by individuals during mating). The process of genetic selection is driven by environmental pressures, such as predation, competition for resources, and changes in the availability of food or habitat.

Population Genetics is a subfield of genetics that deals with the genetic composition of populations and how this composition changes over time. It involves the study of the frequency and distribution of genes and genetic variations in populations, as well as the evolutionary forces that contribute to these patterns, such as mutation, gene flow, genetic drift, and natural selection.

Population genetics can provide insights into a wide range of topics, including the history and relationships between populations, the genetic basis of diseases and other traits, and the potential impacts of environmental changes on genetic diversity. This field is important for understanding evolutionary processes at the population level and has applications in areas such as conservation biology, medical genetics, and forensic science.

Genetic variation refers to the differences in DNA sequences among individuals and populations. These variations can result from mutations, genetic recombination, or gene flow between populations. Genetic variation is essential for evolution by providing the raw material upon which natural selection acts. It can occur within a single gene, between different genes, or at larger scales, such as differences in the number of chromosomes or entire sets of chromosomes. The study of genetic variation is crucial in understanding the genetic basis of diseases and traits, as well as the evolutionary history and relationships among species.

Genetic models are theoretical frameworks used in genetics to describe and explain the inheritance patterns and genetic architecture of traits, diseases, or phenomena. These models are based on mathematical equations and statistical methods that incorporate information about gene frequencies, modes of inheritance, and the effects of environmental factors. They can be used to predict the probability of certain genetic outcomes, to understand the genetic basis of complex traits, and to inform medical management and treatment decisions.

There are several types of genetic models, including:

1. Mendelian models: These models describe the inheritance patterns of simple genetic traits that follow Mendel's laws of segregation and independent assortment. Examples include autosomal dominant, autosomal recessive, and X-linked inheritance.
2. Complex trait models: These models describe the inheritance patterns of complex traits that are influenced by multiple genes and environmental factors. Examples include heart disease, diabetes, and cancer.
3. Population genetics models: These models describe the distribution and frequency of genetic variants within populations over time. They can be used to study evolutionary processes, such as natural selection and genetic drift.
4. Quantitative genetics models: These models describe the relationship between genetic variation and phenotypic variation in continuous traits, such as height or IQ. They can be used to estimate heritability and to identify quantitative trait loci (QTLs) that contribute to trait variation.
5. Statistical genetics models: These models use statistical methods to analyze genetic data and infer the presence of genetic associations or linkage. They can be used to identify genetic risk factors for diseases or traits.

Overall, genetic models are essential tools in genetics research and medical genetics, as they allow researchers to make predictions about genetic outcomes, test hypotheses about the genetic basis of traits and diseases, and develop strategies for prevention, diagnosis, and treatment.

Molecular evolution is the process of change in the DNA sequence or protein structure over time, driven by mechanisms such as mutation, genetic drift, gene flow, and natural selection. It refers to the evolutionary study of changes in DNA, RNA, and proteins, and how these changes accumulate and lead to new species and diversity of life. Molecular evolution can be used to understand the history and relationships among different organisms, as well as the functional consequences of genetic changes.

Gene frequency, also known as allele frequency, is a measure in population genetics that reflects the proportion of a particular gene or allele (variant of a gene) in a given population. It is calculated as the number of copies of a specific allele divided by the total number of all alleles at that genetic locus in the population.

For example, if we consider a gene with two possible alleles, A and a, the gene frequency of allele A (denoted as p) can be calculated as follows:

p = (number of copies of allele A) / (total number of all alleles at that locus)

Similarly, the gene frequency of allele a (denoted as q) would be:

q = (number of copies of allele a) / (total number of all alleles at that locus)

Since there are only two possible alleles for this gene in this example, p + q = 1. These frequencies can help researchers understand genetic diversity and evolutionary processes within populations.

Biological evolution is the change in the genetic composition of populations of organisms over time, from one generation to the next. It is a process that results in descendants differing genetically from their ancestors. Biological evolution can be driven by several mechanisms, including natural selection, genetic drift, gene flow, and mutation. These processes can lead to changes in the frequency of alleles (variants of a gene) within populations, resulting in the development of new species and the extinction of others over long periods of time. Biological evolution provides a unifying explanation for the diversity of life on Earth and is supported by extensive evidence from many different fields of science, including genetics, paleontology, comparative anatomy, and biogeography.

Gene flow, also known as genetic migration or gene admixture, refers to the transfer of genetic variation from one population to another. It occurs when individuals reproduce and exchange genes with members of other populations through processes such as migration and interbreeding. This can result in an alteration of the genetic composition of both populations, increasing genetic diversity and reducing the differences between them. Gene flow is an important mechanism in evolutionary biology and population genetics, contributing to the distribution and frequency of alleles (versions of a gene) within and across populations.

Phylogeny is the evolutionary history and relationship among biological entities, such as species or genes, based on their shared characteristics. In other words, it refers to the branching pattern of evolution that shows how various organisms have descended from a common ancestor over time. Phylogenetic analysis involves constructing a tree-like diagram called a phylogenetic tree, which depicts the inferred evolutionary relationships among organisms or genes based on molecular sequence data or other types of characters. This information is crucial for understanding the diversity and distribution of life on Earth, as well as for studying the emergence and spread of diseases.

I'm sorry for any confusion, but "geography" is not a term that has a medical definition. Geography is a field of study that deals with the location and distribution of physical and cultural features on Earth's surface, as well as how humans interact with and affect those features. It is not a concept that is typically used in a medical context. If you have any questions related to medicine or healthcare, I would be happy to try to help answer them for you!

Microsatellite repeats, also known as short tandem repeats (STRs), are repetitive DNA sequences made up of units of 1-6 base pairs that are repeated in a head-to-tail manner. These repeats are spread throughout the human genome and are highly polymorphic, meaning they can have different numbers of repeat units in different individuals.

Microsatellites are useful as genetic markers because of their high degree of variability. They are commonly used in forensic science to identify individuals, in genealogy to trace ancestry, and in medical research to study genetic diseases and disorders. Mutations in microsatellite repeats have been associated with various neurological conditions, including Huntington's disease and fragile X syndrome.

I'm sorry for any confusion, but "population density" is actually a term used in population geography and epidemiology, rather than medical terminology. It refers to the number of people living in a specific area or region, usually measured as the number of people per square mile or square kilometer.

However, understanding population density can be important in public health and medicine because it can influence various factors related to health outcomes and healthcare delivery, such as:

1. Disease transmission rates: Higher population densities can facilitate the spread of infectious diseases, particularly those that are transmitted through close contact between individuals.
2. Access to healthcare services: Areas with lower population density might have fewer healthcare resources and providers available, making it more challenging for residents to access necessary medical care.
3. Health disparities: Population density can contribute to health inequities, as urban areas often have better access to healthcare, education, and economic opportunities than rural areas, leading to differences in health outcomes between these populations.
4. Environmental factors: Higher population densities might lead to increased pollution, noise, and other environmental hazards that can negatively impact health.

Therefore, while "population density" is not a medical definition per se, it remains an essential concept for understanding various public health and healthcare issues.

The Founder Effect is a concept in population genetics that refers to the loss of genetic variation that occurs when a new colony is established by a small number of individuals from a larger population. This decrease in genetic diversity can lead to an increase in homozygosity, which can in turn result in a higher frequency of certain genetic disorders or traits within the founding population and its descendants. The Founder Effect is named after the "founding" members of the new colony who carry and pass on their particular set of genes to the next generations. It is one of the mechanisms that can lead to the formation of distinct populations or even new species over time.

An allele is a variant form of a gene that is located at a specific position on a specific chromosome. Alleles are alternative forms of the same gene that arise by mutation and are found at the same locus or position on homologous chromosomes.

Each person typically inherits two copies of each gene, one from each parent. If the two alleles are identical, a person is said to be homozygous for that trait. If the alleles are different, the person is heterozygous.

For example, the ABO blood group system has three alleles, A, B, and O, which determine a person's blood type. If a person inherits two A alleles, they will have type A blood; if they inherit one A and one B allele, they will have type AB blood; if they inherit two B alleles, they will have type B blood; and if they inherit two O alleles, they will have type O blood.

Alleles can also influence traits such as eye color, hair color, height, and other physical characteristics. Some alleles are dominant, meaning that only one copy of the allele is needed to express the trait, while others are recessive, meaning that two copies of the allele are needed to express the trait.

Mitochondrial DNA (mtDNA) is the genetic material present in the mitochondria, which are specialized structures within cells that generate energy. Unlike nuclear DNA, which is present in the cell nucleus and inherited from both parents, mtDNA is inherited solely from the mother.

MtDNA is a circular molecule that contains 37 genes, including 13 genes that encode for proteins involved in oxidative phosphorylation, a process that generates energy in the form of ATP. The remaining genes encode for rRNAs and tRNAs, which are necessary for protein synthesis within the mitochondria.

Mutations in mtDNA can lead to a variety of genetic disorders, including mitochondrial diseases, which can affect any organ system in the body. These mutations can also be used in forensic science to identify individuals and establish biological relationships.

Genetic structures refer to the organization and composition of genetic material, primarily DNA, that contain the information necessary for the development and function of an organism. This includes the chromosomes, genes, and regulatory elements that make up the genome.

Chromosomes are thread-like structures located in the nucleus of a cell that consist of DNA coiled around histone proteins. They come in pairs, with most species having a specific number of chromosomes in each set (diploid).

Genes are segments of DNA that code for specific proteins or RNA molecules, and they are the basic units of heredity. They can be located on chromosomes and can vary in length and complexity.

Regulatory elements are non-coding sequences of DNA that control the expression of genes by regulating when, where, and to what extent a gene is turned on or off. These elements can include promoters, enhancers, silencers, and insulators.

Overall, genetic structures provide the blueprint for an organism's traits and characteristics, and understanding their organization and function is crucial in fields such as genetics, genomics, and molecular biology.

A haplotype is a group of genes or DNA sequences that are inherited together from a single parent. It refers to a combination of alleles (variant forms of a gene) that are located on the same chromosome and are usually transmitted as a unit. Haplotypes can be useful in tracing genetic ancestry, understanding the genetic basis of diseases, and developing personalized medical treatments.

In population genetics, haplotypes are often used to study patterns of genetic variation within and between populations. By comparing haplotype frequencies across populations, researchers can infer historical events such as migrations, population expansions, and bottlenecks. Additionally, haplotypes can provide information about the evolutionary history of genes and genomic regions.

In clinical genetics, haplotypes can be used to identify genetic risk factors for diseases or to predict an individual's response to certain medications. For example, specific haplotypes in the HLA gene region have been associated with increased susceptibility to certain autoimmune diseases, while other haplotypes in the CYP450 gene family can affect how individuals metabolize drugs.

Overall, haplotypes provide a powerful tool for understanding the genetic basis of complex traits and diseases, as well as for developing personalized medical treatments based on an individual's genetic makeup.

An endangered species is a species of animal, plant, or other organism that is at risk of becoming extinct because its population is declining or threatened by changing environmental or demographic factors. This term is defined and used in the context of conservation biology and wildlife management to identify species that need protection and preservation efforts.

The International Union for Conservation of Nature (IUCN) maintains a "Red List" of species, categorizing them based on their extinction risk. The categories include "Critically Endangered," "Endangered," "Vulnerable," and "Near Threatened." A species is considered endangered if it meets certain criteria indicating that it faces a very high risk of extinction in the wild.

The primary causes for species to become endangered include habitat loss, fragmentation, degradation, pollution, climate change, overexploitation, and introduction of invasive species. Conservation efforts often focus on protecting habitats, managing threats, and implementing recovery programs to help endangered species recover their populations and reduce the risk of extinction.

Population dynamics, in the context of public health and epidemiology, refers to the study of the changes in size and structure of a population over time, as well as the factors that contribute to those changes. This can include birth rates, death rates, migration patterns, aging, and other demographic characteristics. Understanding population dynamics is crucial for planning and implementing public health interventions, such as vaccination programs or disease prevention strategies, as they allow researchers and policymakers to identify vulnerable populations, predict future health trends, and evaluate the impact of public health initiatives.

Genetic load is a term used in population genetics that refers to the reduction in average fitness (or reproductive success) of a population due to the presence of deleterious or harmful alleles (versions of genes). These alleles can negatively impact an individual's survival, reproduction, or both. Genetic load can be caused by various factors such as mutations, genetic drift, and selection.

There are several types of genetic load, including:

1. Mutation load: The decrease in fitness due to the accumulation of new deleterious mutations in a population over time.
2. Segregation load: The reduction in average fitness caused by the presence of recessive deleterious alleles that are hidden in heterozygotes (individuals with one normal and one deleterious allele).
3. Inbreeding load: The decrease in fitness due to an increase in homozygosity (the presence of identical alleles on both chromosomes) resulting from inbreeding, which exposes recessive deleterious alleles.
4. Genetic drift load: The reduction in fitness caused by the random loss of beneficial or neutral alleles due to genetic drift, leading to a decrease in genetic diversity and an increase in the frequency of deleterious alleles.
5. Coevolutionary load: The decline in fitness resulting from the disruption of coadapted gene complexes (combinations of interacting genes) when populations are separated or experience environmental changes.

Overall, genetic load represents the cost of maintaining genetic variation within a population and can impact its long-term evolutionary potential and adaptability to changing environments.

A mutation is a permanent change in the DNA sequence of an organism's genome. Mutations can occur spontaneously or be caused by environmental factors such as exposure to radiation, chemicals, or viruses. They may have various effects on the organism, ranging from benign to harmful, depending on where they occur and whether they alter the function of essential proteins. In some cases, mutations can increase an individual's susceptibility to certain diseases or disorders, while in others, they may confer a survival advantage. Mutations are the driving force behind evolution, as they introduce new genetic variability into populations, which can then be acted upon by natural selection.

Genetic polymorphism refers to the occurrence of multiple forms (called alleles) of a particular gene within a population. These variations in the DNA sequence do not generally affect the function or survival of the organism, but they can contribute to differences in traits among individuals. Genetic polymorphisms can be caused by single nucleotide changes (SNPs), insertions or deletions of DNA segments, or other types of genetic rearrangements. They are important for understanding genetic diversity and evolution, as well as for identifying genetic factors that may contribute to disease susceptibility in humans.

I'm sorry for any confusion, but "Jews" is not a medical term. It is a term used to describe a group of people who share cultural, religious, and ethnic heritage. The Jewish people originated from the ancient kingdoms of Israel and Judah. They are bound together by their religion, Judaism, which is based on the Torah, or the five books of Moses.

If you have any medical questions or terms that you would like defined, I'd be happy to help!

Physical anthropology is a subfield of anthropology that focuses on the study of human biological variation and evolution, both in the past and in the present. It draws upon various scientific disciplines such as genetics, anatomy, physiology, and paleontology to understand the biological origins and development of our species, Homo sapiens.

Physical anthropologists study a wide range of topics, including human and primate evolution, population genetics, skeletal biology, forensic anthropology, and bioarchaeology. They often work with fossil remains, archaeological sites, and living populations to investigate questions related to human adaptation, health, migration, and diversity.

By examining the biological aspects of human existence, physical anthropologists aim to contribute to a more comprehensive understanding of what it means to be human, both in terms of our shared characteristics as a species and the unique variations that make each individual and population distinct.

Amplified Fragment Length Polymorphism (AFLP) analysis is a molecular biology technique used for DNA fingerprinting, genetic mapping, and population genetics studies. It is based on the selective amplification of restriction fragments from a total digest of genomic DNA, followed by separation and detection of the resulting fragments using polyacrylamide gel electrophoresis.

In AFLP analysis, genomic DNA is first digested with two different restriction enzymes, one that cuts frequently (e.g., EcoRI) and another that cuts less frequently (e.g., MseI). The resulting fragments are then ligated to adapter sequences that provide recognition sites for PCR amplification.

Selective amplification of the restriction fragments is achieved by using primers that anneal to the adapter sequences and contain additional selective nucleotides at their 3' ends. This allows for the amplification of a subset of the total number of restriction fragments, resulting in a pattern of bands that is specific to the DNA sample being analyzed.

The amplified fragments are then separated by size using polyacrylamide gel electrophoresis and visualized by staining with a fluorescent dye. The resulting banding pattern can be used for various applications, including identification of genetic differences between individuals, detection of genomic alterations in cancer cells, and analysis of population structure and diversity.

Overall, AFLP analysis is a powerful tool for the study of complex genomes and has been widely used in various fields of biology, including plant and animal breeding, forensic science, and medical research.

Genetic fitness is a term used in the field of genetics and evolutionary biology to describe the ability of an individual organism to survive and reproduce, passing its genes on to the next generation. An organism that is highly genetically fit has a greater likelihood of producing offspring that will also survive and reproduce, thereby ensuring the survival of its genetic traits in the population.

In the context of human genetics, genetic fitness may refer to the ability of an individual to pass on their genes to future generations due to certain genetic traits or characteristics that enhance their chances of survival and reproduction. However, it is important to note that the concept of "fitness" in this context does not necessarily imply superiority or inferiority, but rather a measure of reproductive success.

It's also worth noting that genetic fitness can be influenced by various factors such as environmental conditions, cultural practices, and social structures, which can all interact with an individual's genetic traits to affect their overall fitness.

DNA Sequence Analysis is the systematic determination of the order of nucleotides in a DNA molecule. It is a critical component of modern molecular biology, genetics, and genetic engineering. The process involves determining the exact order of the four nucleotide bases - adenine (A), guanine (G), cytosine (C), and thymine (T) - in a DNA molecule or fragment. This information is used in various applications such as identifying gene mutations, studying evolutionary relationships, developing molecular markers for breeding, and diagnosing genetic diseases.

The process of DNA Sequence Analysis typically involves several steps, including DNA extraction, PCR amplification (if necessary), purification, sequencing reaction, and electrophoresis. The resulting data is then analyzed using specialized software to determine the exact sequence of nucleotides.

In recent years, high-throughput DNA sequencing technologies have revolutionized the field of genomics, enabling the rapid and cost-effective sequencing of entire genomes. This has led to an explosion of genomic data and new insights into the genetic basis of many diseases and traits.

Inbreeding, in a medical context, refers to the practice of mating closely related individuals within a given family or breeding population. This leads to an increased proportion of homozygous genes, meaning that the same alleles (versions of a gene) are inherited from both parents. As a result, recessive traits and disorders become more likely to be expressed because the necessary dominant allele may be absent.

In human medicine, consanguinity is the term often used instead of inbreeding, and it refers to relationships between individuals who share a common ancestor. Consanguinity increases the risk of certain genetic disorders due to the increased likelihood of sharing harmful recessive genes. The closer the relationship, the higher the risk.

In animal breeding, inbreeding can lead to reduced fertility, lower birth weights, higher infant mortality, and a decreased lifespan. It is crucial to maintain genetic diversity within populations to ensure their overall health and vigor.

Physiological processes refer to the functional activities or functions of living organisms and their parts, including cells, tissues, and organs. These processes are necessary for the maintenance of life and include various functions such as:

1. Metabolism: the sum of all chemical reactions that occur in the body to maintain life, including anabolic (building up) and catabolic (breaking down) processes.
2. Circulation: the movement of blood and other fluids throughout the body, which helps transport nutrients, oxygen, and waste products.
3. Respiration: the process of gas exchange between the body and the environment, involving the inhalation of oxygen and the exhalation of carbon dioxide.
4. Digestion: the breakdown of food into smaller molecules that can be absorbed and utilized by the body for energy and growth.
5. Nerve impulse transmission: the electrical signals that transmit information between neurons and other cells in the body.
6. Endocrine regulation: the release and transport of hormones that regulate various physiological processes, such as growth, development, and metabolism.
7. Immune function: the body's defense system against foreign invaders, such as bacteria, viruses, and toxins.
8. Reproduction: the process of producing offspring through sexual or asexual means.
9. Maintenance of homeostasis: the ability of the body to maintain a stable internal environment despite changes in external conditions.

Physiological processes are regulated by complex systems of feedback and control, involving various hormones, nerves, and other signaling molecules. Understanding these processes is essential for understanding how the body functions and how to diagnose and treat various medical conditions.

Linkage disequilibrium (LD) is a term used in genetics that refers to the non-random association of alleles at different loci (genetic locations) on a chromosome. This means that certain combinations of genetic variants, or alleles, at different loci occur more frequently together in a population than would be expected by chance.

Linkage disequilibrium can arise due to various factors such as genetic drift, selection, mutation, and population structure. It is often used in the context of genetic mapping studies to identify regions of the genome that are associated with particular traits or diseases. High levels of LD in a region of the genome suggest that the loci within that region are in linkage, meaning they tend to be inherited together.

The degree of LD between two loci can be measured using various statistical methods, such as D' and r-squared. These measures provide information about the strength and direction of the association between alleles at different loci, which can help researchers identify causal genetic variants underlying complex traits or diseases.

A gene pool refers to the total sum of genes contained within a population of interbreeding individuals of a species. It includes all the variations of genes, or alleles, that exist in that population. The concept of a gene pool is important in understanding genetic diversity and how traits are passed down from one generation to the next.

The size and diversity of a gene pool can have significant implications for the long-term survival and adaptability of a species. A larger and more diverse gene pool can provide a species with greater resistance to diseases, environmental changes, and other threats, as there is a wider variety of traits and genetic combinations available. On the other hand, a smaller or less diverse gene pool may make a species more susceptible to genetic disorders, reduced fitness, and extinction.

Geneticists and population biologists often study gene pools to understand the evolutionary history and dynamics of populations, as well as to inform conservation efforts for endangered species.

Genotype, in genetics, refers to the complete heritable genetic makeup of an individual organism, including all of its genes. It is the set of instructions contained in an organism's DNA for the development and function of that organism. The genotype is the basis for an individual's inherited traits, and it can be contrasted with an individual's phenotype, which refers to the observable physical or biochemical characteristics of an organism that result from the expression of its genes in combination with environmental influences.

It is important to note that an individual's genotype is not necessarily identical to their genetic sequence. Some genes have multiple forms called alleles, and an individual may inherit different alleles for a given gene from each parent. The combination of alleles that an individual inherits for a particular gene is known as their genotype for that gene.

Understanding an individual's genotype can provide important information about their susceptibility to certain diseases, their response to drugs and other treatments, and their risk of passing on inherited genetic disorders to their offspring.

Buchnera is a genus of gram-negative, intracellular bacteria that are associated with sap-sucking insects, particularly aphids. These bacteria have a mutualistic relationship with their insect hosts, where the bacteria receive nutrients and protection from the host while providing essential amino acids and other compounds that the insect cannot synthesize on its own. The name Buchnera honors the German zoologist and entomologist, Paul Buchner, who made significant contributions to the study of insect symbiosis.

Species specificity is a term used in the field of biology, including medicine, to refer to the characteristic of a biological entity (such as a virus, bacterium, or other microorganism) that allows it to interact exclusively or preferentially with a particular species. This means that the biological entity has a strong affinity for, or is only able to infect, a specific host species.

For example, HIV is specifically adapted to infect human cells and does not typically infect other animal species. Similarly, some bacterial toxins are species-specific and can only affect certain types of animals or humans. This concept is important in understanding the transmission dynamics and host range of various pathogens, as well as in developing targeted therapies and vaccines.

Genetic speciation is not a widely used term in the scientific literature, but it generally refers to the process by which new species arise due to genetic differences and reproductive isolation. This process can occur through various mechanisms such as mutation, gene flow, genetic drift, natural selection, or chromosomal changes that lead to the accumulation of genetic differences between populations. Over time, these genetic differences can result in the development of reproductive barriers that prevent interbreeding between the populations, leading to the formation of new species.

In other words, genetic speciation is a type of speciation that involves the evolution of genetic differences that ultimately lead to the formation of new species. It is an essential concept in the field of evolutionary biology and genetics, as it explains how biodiversity arises over time.

Biological adaptation is the process by which a organism becomes better suited to its environment over generations as a result of natural selection. It involves changes in an organism's structure, metabolism, or behavior that increase its fitness, or reproductive success, in a given environment. These changes are often genetic and passed down from one generation to the next through the process of inheritance.

Examples of biological adaptation include the development of camouflage in animals, the ability of plants to photosynthesize, and the development of antibiotic resistance in bacteria. Biological adaptation is an important concept in the field of evolutionary biology and helps to explain the diversity of life on Earth.

Molecular sequence data refers to the specific arrangement of molecules, most commonly nucleotides in DNA or RNA, or amino acids in proteins, that make up a biological macromolecule. This data is generated through laboratory techniques such as sequencing, and provides information about the exact order of the constituent molecules. This data is crucial in various fields of biology, including genetics, evolution, and molecular biology, allowing for comparisons between different organisms, identification of genetic variations, and studies of gene function and regulation.

I apologize for any confusion, but "Pinus ponderosa" is not a medical term. It is the scientific name for a species of pine tree commonly known as the western yellow pine or ponderosa pine. This tree is native to North America and is one of the most widely distributed pine species in the continent.

Here's a brief overview of its botanical characteristics:

Kingdom: Plantae
Division: Pinophyta
Class: Pinopsida
Order: Pinales
Family: Pinaceae
Genus: Pinus
Species: P. ponderosa

The ponderosa pine is a large evergreen tree, reaching heights of 150-250 feet (46-76 meters) tall and trunk diameters up to 8 feet (2.4 meters). Its needle-like leaves are grouped in bundles of three, and its cones are long and slender, typically 3-6 inches (7.6-15.2 cm) in length.

If you have any questions related to medical terminology or healthcare topics, please feel free to provide them, and I'd be happy to help.

An "ecosystem" is not a term that has a specific medical definition, as it is a concept that is more commonly used in the fields of ecology and environmental science. However, I can provide you with the general ecological definition of an ecosystem:

An ecosystem is a community of living organisms interacting with each other and their non-living environment, including both biotic factors (plants, animals, microorganisms) and abiotic factors (climate, soil, water, and air). These interactions create a complex network of relationships that form the foundation of ecological processes, such as energy flow, nutrient cycling, and population dynamics.

While there is no direct medical definition for an ecosystem, understanding the principles of ecosystems can have important implications for human health. For example, healthy ecosystems can provide clean air and water, regulate climate, support food production, and offer opportunities for recreation and relaxation, all of which contribute to overall well-being. Conversely, degraded ecosystems can lead to increased exposure to environmental hazards, reduced access to natural resources, and heightened risks of infectious diseases. Therefore, maintaining the health and integrity of ecosystems is crucial for promoting human health and preventing disease.

A computer simulation is a process that involves creating a model of a real-world system or phenomenon on a computer and then using that model to run experiments and make predictions about how the system will behave under different conditions. In the medical field, computer simulations are used for a variety of purposes, including:

1. Training and education: Computer simulations can be used to create realistic virtual environments where medical students and professionals can practice their skills and learn new procedures without risk to actual patients. For example, surgeons may use simulation software to practice complex surgical techniques before performing them on real patients.
2. Research and development: Computer simulations can help medical researchers study the behavior of biological systems at a level of detail that would be difficult or impossible to achieve through experimental methods alone. By creating detailed models of cells, tissues, organs, or even entire organisms, researchers can use simulation software to explore how these systems function and how they respond to different stimuli.
3. Drug discovery and development: Computer simulations are an essential tool in modern drug discovery and development. By modeling the behavior of drugs at a molecular level, researchers can predict how they will interact with their targets in the body and identify potential side effects or toxicities. This information can help guide the design of new drugs and reduce the need for expensive and time-consuming clinical trials.
4. Personalized medicine: Computer simulations can be used to create personalized models of individual patients based on their unique genetic, physiological, and environmental characteristics. These models can then be used to predict how a patient will respond to different treatments and identify the most effective therapy for their specific condition.

Overall, computer simulations are a powerful tool in modern medicine, enabling researchers and clinicians to study complex systems and make predictions about how they will behave under a wide range of conditions. By providing insights into the behavior of biological systems at a level of detail that would be difficult or impossible to achieve through experimental methods alone, computer simulations are helping to advance our understanding of human health and disease.

'Spatio-temporal analysis' is not a medical term per se, but rather a term used in various scientific fields including epidemiology and public health research to describe the examination of data that contains both geographical and time-based information. In this context, spatio-temporal analysis involves studying how health outcomes or exposures change over time and across different locations.

The goal of spatio-temporal analysis is to identify patterns, trends, and clusters of health events in space and time, which can help inform public health interventions, monitor disease outbreaks, and evaluate the effectiveness of public health policies. For example, spatio-temporal analysis may be used to examine the spread of a infectious disease over time and across different regions, or to assess the impact of environmental exposures on health outcomes in specific communities.

Spatio-temporal analysis typically involves the use of statistical methods and geographic information systems (GIS) tools to visualize and analyze data in a spatially and temporally explicit manner. These methods can help account for confounding factors, such as population density or demographics, that may affect health outcomes and help identify meaningful patterns in complex datasets.

In the context of public health and epidemiology, a population refers to a group of individuals who share common characteristics or are defined by specific boundaries and parameters. These parameters can include geographical location, age range, sex, race, ethnicity, exposure to certain risk factors, or shared health status.

The health status and trends of a population are often studied through surveillance and research to understand the determinants of health, disease patterns, and health disparities within the group. This information is then used to inform public health policies, interventions, and programs aimed at improving the overall health and well-being of the population.

I believe you are asking for a description or explanation of the indigenous peoples of South America, rather than a "medical definition." A medical definition would typically apply to a condition or disease. Here is some information about the indigenous peoples of South America:

The indigenous peoples of South America are the original inhabitants of the continent and its islands, who lived there before the European colonization. They include a wide variety of ethnic groups, languages, and cultures, with distinct histories and traditions. Many indigenous communities in South America have faced significant challenges, including displacement from their lands, marginalization, and discrimination.

According to estimates by the United Nations, there are approximately 45 million indigenous people in Latin America, of which about 30 million live in South America. They represent around 7% of the total population of South America. Indigenous peoples in South America can be found in all countries, with the largest populations in Bolivia (62%), Guatemala (41%), and Peru (25%).

Indigenous peoples in South America have a rich cultural heritage, including unique languages, arts, and spiritual practices. Many of these cultures are under threat due to globalization, urbanization, and the loss of traditional lands and resources. In recent years, there has been increased recognition of the rights of indigenous peoples in international law, including the right to self-determination, cultural heritage, and free, prior, and informed consent for projects that affect their territories. However, significant challenges remain, and many indigenous communities continue to face violence, discrimination, and poverty.

A heterozygote is an individual who has inherited two different alleles (versions) of a particular gene, one from each parent. This means that the individual's genotype for that gene contains both a dominant and a recessive allele. The dominant allele will be expressed phenotypically (outwardly visible), while the recessive allele may or may not have any effect on the individual's observable traits, depending on the specific gene and its function. Heterozygotes are often represented as 'Aa', where 'A' is the dominant allele and 'a' is the recessive allele.

"Likelihood functions" is a statistical concept that is used in medical research and other fields to estimate the probability of obtaining a given set of data, given a set of assumptions or parameters. In other words, it is a function that describes how likely it is to observe a particular outcome or result, based on a set of model parameters.

More formally, if we have a statistical model that depends on a set of parameters θ, and we observe some data x, then the likelihood function is defined as:

L(θ | x) = P(x | θ)

This means that the likelihood function describes the probability of observing the data x, given a particular value of the parameter vector θ. By convention, the likelihood function is often expressed as a function of the parameters, rather than the data, so we might instead write:

L(θ) = P(x | θ)

The likelihood function can be used to estimate the values of the model parameters that are most consistent with the observed data. This is typically done by finding the value of θ that maximizes the likelihood function, which is known as the maximum likelihood estimator (MLE). The MLE has many desirable statistical properties, including consistency, efficiency, and asymptotic normality.

In medical research, likelihood functions are often used in the context of Bayesian analysis, where they are combined with prior distributions over the model parameters to obtain posterior distributions that reflect both the observed data and prior knowledge or assumptions about the parameter values. This approach is particularly useful when there is uncertainty or ambiguity about the true value of the parameters, as it allows researchers to incorporate this uncertainty into their analyses in a principled way.

Tephritidae is a family of flies commonly known as "fruit flies" or "vinegar flies." The term "Tephritidae" is derived from the Greek word "tephra," which means "ash," likely referring to the often gray or sooty coloration of some members of this family.

Tephritidae includes over 4,000 species worldwide, many of which are important agricultural pests. These flies are known for their habit of laying eggs in or on fruits and vegetables, leading to the development of larvae that feed on the plant tissue and cause damage. Some well-known examples of Tephritidae include the Mediterranean fruit fly (Ceratitis capitata) and the apple maggot (Rhagoletis pomonella).

It is worth noting that "fruit flies" is also a common name for Drosophilidae, another family of small flies. While both families are sometimes referred to as "fruit flies," Tephritidae species tend to be larger and more brightly colored than Drosophilidae species.

Hominidae, also known as the "great apes," is a family of primates that includes humans (Homo sapiens), orangutans (Pongo pygmaeus), gorillas (Gorilla gorilla and Gorilla beringei), bonobos (Pan paniscus), and chimpanzees (Pan troglodytes). This family is characterized by their upright walking ability, although not all members exhibit this trait. Hominidae species are known for their high intelligence, complex social structures, and expressive facial features. They share a common ancestor with the Old World monkeys, and fossil records suggest that this split occurred around 25 million years ago.

Emigration is the process of leaving one's country of origin or habitual residence to settle in another country. It involves giving up the rights and privileges associated with citizenship in the country of origin and acquiring new rights and responsibilities as a citizen or resident of the destination country. Emigrants are people who choose to leave their native land to live elsewhere, often driven by factors such as economic opportunities, political instability, or conflict.

Immigration, on the other hand, is the process of entering and settling in a new country with the intention of becoming a permanent resident or citizen. Immigrants are individuals who come from another country to live in a new place, often seeking better job opportunities, education, or quality of life. They must comply with the immigration laws and regulations of the host country and may be required to undergo medical examinations, background checks, and other screening processes before being granted permission to enter and reside in the country.

In summary, emigration refers to leaving one's home country, while immigration refers to entering and settling in a new country.

I'm sorry for any confusion, but "Stochastic Processes" is actually a term from the field of mathematics, specifically probability theory and statistics. It doesn't have a direct medical definition.

However, to provide some context that might be relevant if you're studying a medical field with a strong statistical component: A stochastic process is a mathematical model used to describe random systems that evolve over time. It consists of a set of random variables indexed by time or some other parameter. The values of these variables at different times or parameters are not independent, but rather depend on each other in ways described by probability distributions.

In medical research, stochastic processes might be used to model the spread of a disease through a population over time, or the changing health status of an individual patient over the course of their treatment. However, it's important to note that this is a high-level overview and the specific use of stochastic processes in medical research would depend on the particular application.

Reproduction, in the context of biology and medicine, refers to the process by which organisms produce offspring. It is a complex process that involves the creation, development, and growth of new individuals from parent organisms. In sexual reproduction, this process typically involves the combination of genetic material from two parents through the fusion of gametes (sex cells) such as sperm and egg cells. This results in the formation of a zygote, which then develops into a new individual with a unique genetic makeup.

In contrast, asexual reproduction does not involve the fusion of gametes and can occur through various mechanisms such as budding, fragmentation, or parthenogenesis. Asexual reproduction results in offspring that are genetically identical to the parent organism.

Reproduction is a fundamental process that ensures the survival and continuation of species over time. It is also an area of active research in fields such as reproductive medicine, where scientists and clinicians work to understand and address issues related to human fertility, contraception, and genetic disorders.

Genetic markers are specific segments of DNA that are used in genetic mapping and genotyping to identify specific genetic locations, diseases, or traits. They can be composed of short tandem repeats (STRs), single nucleotide polymorphisms (SNPs), restriction fragment length polymorphisms (RFLPs), or variable number tandem repeats (VNTRs). These markers are useful in various fields such as genetic research, medical diagnostics, forensic science, and breeding programs. They can help to track inheritance patterns, identify genetic predispositions to diseases, and solve crimes by linking biological evidence to suspects or victims.

Bayes' theorem, also known as Bayes' rule or Bayes' formula, is a fundamental principle in the field of statistics and probability theory. It describes how to update the probability of a hypothesis based on new evidence or data. The theorem is named after Reverend Thomas Bayes, who first formulated it in the 18th century.

In mathematical terms, Bayes' theorem states that the posterior probability of a hypothesis (H) given some observed evidence (E) is proportional to the product of the prior probability of the hypothesis (P(H)) and the likelihood of observing the evidence given the hypothesis (P(E|H)):

Posterior Probability = P(H|E) = [P(E|H) x P(H)] / P(E)

Where:

* P(H|E): The posterior probability of the hypothesis H after observing evidence E. This is the probability we want to calculate.
* P(E|H): The likelihood of observing evidence E given that the hypothesis H is true.
* P(H): The prior probability of the hypothesis H before observing any evidence.
* P(E): The marginal likelihood or probability of observing evidence E, regardless of whether the hypothesis H is true or not. This value can be calculated as the sum of the products of the likelihood and prior probability for all possible hypotheses: P(E) = Σ[P(E|Hi) x P(Hi)]

Bayes' theorem has many applications in various fields, including medicine, where it can be used to update the probability of a disease diagnosis based on test results or other clinical findings. It is also widely used in machine learning and artificial intelligence algorithms for probabilistic reasoning and decision making under uncertainty.

Phylogeography is not a medical term, but rather a subfield of biogeography and phylogenetics that investigates the spatial distribution of genealogical lineages and the historical processes that have shaped them. It uses genetic data to infer the geographic origins, dispersal routes, and demographic history of organisms, including pathogens and vectors that can affect human health.

In medical and public health contexts, phylogeography is often used to study the spread of infectious diseases, such as HIV/AIDS, influenza, or tuberculosis, by analyzing the genetic diversity and geographic distribution of pathogen isolates. This information can help researchers understand how diseases emerge, evolve, and move across populations and landscapes, which can inform disease surveillance, control, and prevention strategies.

I'm sorry for any confusion, but the term "Africa" actually refers to a continent, not a medical condition or concept. Africa is the second-largest continent in the world, consisting of 54 countries and a wide range of diverse ethnic groups, cultures, languages, and landscapes. It is home to a vast array of wildlife, including many species that are not found anywhere else in the world. If you have any questions about Africa's geography, history, or culture, I would be happy to try to help answer them!

A genetic locus (plural: loci) is a specific location on a chromosome where a particular gene or DNA sequence is found. It is the precise position where a specific genetic element, such as a gene or marker, is located on a chromsomere. This location is defined in terms of its relationship to other genetic markers and features on the same chromosome. Genetic loci can be used in linkage and association studies to identify the inheritance patterns and potential relationships between genes and various traits or diseases.

Human Y chromosomes are one of the two sex-determining chromosomes in humans (the other being the X chromosome). They are found in the 23rd pair of human chromosomes and are significantly smaller than the X chromosome.

The Y chromosome is passed down from father to son through the paternal line, and it plays a crucial role in male sex determination. The SRY gene (sex-determining region Y) on the Y chromosome initiates the development of male sexual characteristics during embryonic development.

In addition to the SRY gene, the human Y chromosome contains several other genes that are essential for sperm production and male fertility. However, the Y chromosome has a much lower gene density compared to other chromosomes, with only about 80 protein-coding genes, making it one of the most gene-poor chromosomes in the human genome.

Because of its small size and low gene density, the Y chromosome is particularly susceptible to genetic mutations and deletions, which can lead to various genetic disorders and male infertility. Nonetheless, the Y chromosome remains a critical component of human genetics and evolution, providing valuable insights into sex determination, inheritance patterns, and human diversity.

A base sequence in the context of molecular biology refers to the specific order of nucleotides in a DNA or RNA molecule. In DNA, these nucleotides are adenine (A), guanine (G), cytosine (C), and thymine (T). In RNA, uracil (U) takes the place of thymine. The base sequence contains genetic information that is transcribed into RNA and ultimately translated into proteins. It is the exact order of these bases that determines the genetic code and thus the function of the DNA or RNA molecule.

Animal migration is a seasonal movement of animals from one place to another, typically over long distances, to find food, reproduce, or escape harsh conditions. This phenomenon is observed in various species, including birds, mammals, fish, and insects. The routes and destinations of these migrations are often genetically programmed and can be quite complex. Animal migration has important ecological consequences and is influenced by factors such as climate change, habitat loss, and human activities.

In medical terms, "breeding" is not a term that is commonly used. It is more frequently used in the context of animal husbandry to refer to the process of mating animals in order to produce offspring with specific desired traits or characteristics. In human medicine, the term is not typically applied to people and instead, related concepts such as reproduction, conception, or pregnancy are used.

Genetic recombination is the process by which genetic material is exchanged between two similar or identical molecules of DNA during meiosis, resulting in new combinations of genes on each chromosome. This exchange occurs during crossover, where segments of DNA are swapped between non-sister homologous chromatids, creating genetic diversity among the offspring. It is a crucial mechanism for generating genetic variability and facilitating evolutionary change within populations. Additionally, recombination also plays an essential role in DNA repair processes through mechanisms such as homologous recombinational repair (HRR) and non-homologous end joining (NHEJ).

Aphids, also known as plant lice, are small sap-sucking insects that belong to the superfamily Aphidoidea in the order Hemiptera. They are soft-bodied and pear-shaped, with most species measuring less than 1/8 inch (3 millimeters) long.

Aphids feed on a wide variety of plants by inserting their needle-like mouthparts into the plant's vascular system to extract phloem sap. This feeding can cause stunted growth, yellowing, curling, or distortion of leaves and flowers, and may even lead to the death of the plant in severe infestations.

Aphids reproduce rapidly and can produce several generations per year. Many species give birth to live young (nymphs) rather than laying eggs, which allows them to increase their population numbers quickly. Aphids also have a complex life cycle that may involve sexual reproduction, parthenogenesis (reproduction without fertilization), and winged or wingless forms.

Aphids are an important pest in agriculture and horticulture, causing significant damage to crops and ornamental plants. They can also transmit plant viruses and produce honeydew, a sticky substance that attracts ants and supports the growth of sooty mold fungi.

Controlling aphids may involve cultural practices such as pruning, watering, and removing weeds; biological control using natural enemies such as lady beetles, lacewings, and parasitic wasps; or chemical control using insecticides.

A phenotype is the physical or biochemical expression of an organism's genes, or the observable traits and characteristics resulting from the interaction of its genetic constitution (genotype) with environmental factors. These characteristics can include appearance, development, behavior, and resistance to disease, among others. Phenotypes can vary widely, even among individuals with identical genotypes, due to differences in environmental influences, gene expression, and genetic interactions.

Demography is the statistical study of populations, particularly in terms of size, distribution, and characteristics such as age, race, gender, and occupation. In medical contexts, demography is often used to analyze health-related data and trends within specific populations. This can include studying the prevalence of certain diseases or conditions, identifying disparities in healthcare access and outcomes, and evaluating the effectiveness of public health interventions. Demographic data can also be used to inform policy decisions and allocate resources to address population health needs.

Physiological adaptation refers to the changes or modifications that occur in an organism's biological functions or structures as a result of environmental pressures or changes. These adaptations enable the organism to survive and reproduce more successfully in its environment. They can be short-term, such as the constriction of blood vessels in response to cold temperatures, or long-term, such as the evolution of longer limbs in animals that live in open environments.

In the context of human physiology, examples of physiological adaptation include:

1. Acclimatization: The process by which the body adjusts to changes in environmental conditions, such as altitude or temperature. For example, when a person moves to a high-altitude location, their body may produce more red blood cells to compensate for the lower oxygen levels, leading to improved oxygen delivery to tissues.

2. Exercise adaptation: Regular physical activity can lead to various physiological adaptations, such as increased muscle strength and endurance, enhanced cardiovascular function, and improved insulin sensitivity.

3. Hormonal adaptation: The body can adjust hormone levels in response to changes in the environment or internal conditions. For instance, during prolonged fasting, the body releases stress hormones like cortisol and adrenaline to help maintain energy levels and prevent muscle wasting.

4. Sensory adaptation: Our senses can adapt to different stimuli over time. For example, when we enter a dark room after being in bright sunlight, it takes some time for our eyes to adjust to the new light level. This process is known as dark adaptation.

5. Aging-related adaptations: As we age, various physiological changes occur that help us adapt to the changing environment and maintain homeostasis. These include changes in body composition, immune function, and cognitive abilities.

Sex chromosomes, often denoted as X and Y, are one of the 23 pairs of human chromosomes found in each cell of the body. Normally, females have two X chromosomes (46,XX), and males have one X and one Y chromosome (46,XY). The sex chromosomes play a significant role in determining the sex of an individual. They contain genes that contribute to physical differences between men and women. Any variations or abnormalities in the number or structure of these chromosomes can lead to various genetic disorders and conditions related to sexual development and reproduction.

I'm sorry for any confusion, but there seems to be a misunderstanding. Mathematics is not a medical term; it is a branch of science dedicated to the study of numbers, shapes, and structures. However, mathematics does have many applications in medicine, such as in modeling disease spread, analyzing medical images, or designing clinical trials. If you have any questions related to mathematics in a medical context, I'd be happy to help clarify those for you!

Cluster analysis is a statistical method used to group similar objects or data points together based on their characteristics or features. In medical and healthcare research, cluster analysis can be used to identify patterns or relationships within complex datasets, such as patient records or genetic information. This technique can help researchers to classify patients into distinct subgroups based on their symptoms, diagnoses, or other variables, which can inform more personalized treatment plans or public health interventions.

Cluster analysis involves several steps, including:

1. Data preparation: The researcher must first collect and clean the data, ensuring that it is complete and free from errors. This may involve removing outlier values or missing data points.
2. Distance measurement: Next, the researcher must determine how to measure the distance between each pair of data points. Common methods include Euclidean distance (the straight-line distance between two points) or Manhattan distance (the distance between two points along a grid).
3. Clustering algorithm: The researcher then applies a clustering algorithm, which groups similar data points together based on their distances from one another. Common algorithms include hierarchical clustering (which creates a tree-like structure of clusters) or k-means clustering (which assigns each data point to the nearest centroid).
4. Validation: Finally, the researcher must validate the results of the cluster analysis by evaluating the stability and robustness of the clusters. This may involve re-running the analysis with different distance measures or clustering algorithms, or comparing the results to external criteria.

Cluster analysis is a powerful tool for identifying patterns and relationships within complex datasets, but it requires careful consideration of the data preparation, distance measurement, and validation steps to ensure accurate and meaningful results.

I'm sorry for any confusion, but the term "Europe" is a geographical and political designation, rather than a medical one. It refers to the continent located entirely in the Northern Hemisphere and mostly in the Eastern Hemisphere. It is bordered by the Arctic Ocean to the north, the Atlantic Ocean to the west, and the Mediterranean Sea to the south. Europe is made up of approximately 50 countries, depending on how one defines a "country."

If you have any questions related to medical terminology or health-related topics, I'd be happy to help answer them!

In the context of medicine and healthcare, 'probability' does not have a specific medical definition. However, in general terms, probability is a branch of mathematics that deals with the study of numerical quantities called probabilities, which are assigned to events or sets of events. Probability is a measure of the likelihood that an event will occur. It is usually expressed as a number between 0 and 1, where 0 indicates that the event is impossible and 1 indicates that the event is certain to occur.

In medical research and statistics, probability is often used to quantify the uncertainty associated with statistical estimates or hypotheses. For example, a p-value is a probability that measures the strength of evidence against a hypothesis. A small p-value (typically less than 0.05) suggests that the observed data are unlikely under the assumption of the null hypothesis, and therefore provides evidence in favor of an alternative hypothesis.

Probability theory is also used to model complex systems and processes in medicine, such as disease transmission dynamics or the effectiveness of medical interventions. By quantifying the uncertainty associated with these models, researchers can make more informed decisions about healthcare policies and practices.

Biological models, also known as physiological models or organismal models, are simplified representations of biological systems, processes, or mechanisms that are used to understand and explain the underlying principles and relationships. These models can be theoretical (conceptual or mathematical) or physical (such as anatomical models, cell cultures, or animal models). They are widely used in biomedical research to study various phenomena, including disease pathophysiology, drug action, and therapeutic interventions.

Examples of biological models include:

1. Mathematical models: These use mathematical equations and formulas to describe complex biological systems or processes, such as population dynamics, metabolic pathways, or gene regulation networks. They can help predict the behavior of these systems under different conditions and test hypotheses about their underlying mechanisms.
2. Cell cultures: These are collections of cells grown in a controlled environment, typically in a laboratory dish or flask. They can be used to study cellular processes, such as signal transduction, gene expression, or metabolism, and to test the effects of drugs or other treatments on these processes.
3. Animal models: These are living organisms, usually vertebrates like mice, rats, or non-human primates, that are used to study various aspects of human biology and disease. They can provide valuable insights into the pathophysiology of diseases, the mechanisms of drug action, and the safety and efficacy of new therapies.
4. Anatomical models: These are physical representations of biological structures or systems, such as plastic models of organs or tissues, that can be used for educational purposes or to plan surgical procedures. They can also serve as a basis for developing more sophisticated models, such as computer simulations or 3D-printed replicas.

Overall, biological models play a crucial role in advancing our understanding of biology and medicine, helping to identify new targets for therapeutic intervention, develop novel drugs and treatments, and improve human health.

Biology is the scientific study of living organisms and their vital processes. It deals with the characteristics, classification, and behaviors of plants, animals, and microorganisms, as well as how they interact with each other and the environment. Biology covers a wide range of topics, including genetics, cell biology, evolution, ecology, and physiology. The goal of biological research is to understand the fundamental principles that govern the functioning of living systems and to apply this knowledge to improve human health, agriculture, and the environment.

Genetic drift, also known as random genetic drift, allelic drift or the Wright effect, is the change in the frequency of an ... One important alternative source of stochasticity, perhaps more important than genetic drift, is genetic draft. Genetic draft ... which claims that most of the genetic changes are caused by genetic drift acting on neutral mutations. The role of genetic ... then given the same overall speed of genetic drift (the variance effective population size), genetic drift is a less powerful ...
Get new reasons to believe sent to your inbox each week, including well-researched blogs, the latest online courses, upcoming events, and ministry updates.. ...
In Wrights view, genetic drift means change in allele frequency, steady genetic drift including directional terms such as ... would also count as drift.. Thats a population bottleneck, a classic example of genetic drift. ... The title of Charles talk was "Its ok to call genetic drift a force," a position - I should state right at the beginning - ... This morning I am following a session on genetic drift at the American Philosophical Association meetings in Atlanta. It is ...
What is genetic drift explain with example?. Genetic drift is the drifting of the frequency of an allele relative to that of ... What is genetic drift?. Genetic drift describes random fluctuations in the numbers of gene variants in a population. Genetic ... What causes genetic drift?. Genetic drift is usually considered as a random change in the gene of a group population which has ... Genetic drift can result in the loss of rare alleles, and can decrease the size of the gene pool. Genetic drift can also cause ...
Title: Self-Replication, Spontaneous Mutations, and Exponential Genetic Drift in Neural Cellular Automata. Authors: Lana ... inheritable mutations and exponential genetic drift in Neural Cellular Automata. Despite the models not being explicitly ... trained for mutation or inheritability, the descendant patterns exponentially drift away from ancestral patterns, even when the ...
... with embedded questions aligned to Common Core and Depth of Knowledge (DOK) as well as ... How does genetic drift impact allele frequencies in a population?. STANDARDS:. RST.1 - Analysis & Evidence, RST.2 - Main Ideas ...
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Sample Essay on Genetic Drift. Genetic Drift. Genetic drift is also called allelic drift. It is change that occurs in the ... Genetic drift can cause a loss of genetic traits in a population. A genetic trait can also become widespread in the population ... Order an essay on genetic drift online. Are you struggling to beat the set submission deadline for your essay on genetic drift ... Many scientists view genetic drifts in statistical drift in a population over time due to the effects that random sampling have ...
Genetic Drift Open Access Journals. We experimentally and numerically investigate the evolutionary dynamics of four competing ... an expansion length beyond which selection dominates over genetic drift; (2) a characteristic angular correlation describing ... and the relative rates of genetic domain wall annihilations and coalescences to simulations modeling the population as a one- ... the size of genetic domains; and (3) a dimensionless constant quantifying the interplay between a colonys curvature at the ...
Genetic drift as another mode of evolution is particularly difficult to convey. The phrase itself, genetic drift, is confusing- ... to measure student performance before and after instruction on genetic drift. We found that students understanding of genetic ... 2016). The Genetic Drift and Bottlenecked Ferrets lab, an interactive tutorial developed by SimBio, does an excellent job at ... We used the Genetic Drift Inventory (or GeDI, may the force be with you, Price et al. 2014) ...
What is genetic drift?. Genetic drift describes random fluctuations in the numbers of gene variants in a population. Genetic ... In these cases, genetic drift can result in the loss of rare alleles and decrease the gene pool. Genetic drift can cause a new ... Are blue eyes genetic drift?. This is genetic drift…the percentage of blue eye alleles has decreased in the population because ... What can genetic drift be best defined as?. Definition: Genetic drift is defined as the changing of the number of available ...
Evolutionary rate and genetic drift of hepatitis C virus are not correlated with the host immune response: Studies of infected ... Evolutionary rate and genetic drift of hepatitis C virus are not correlated with the host immune response: Studies of infected ...
The effectiveness of Genie to teach key genetic drift concepts and misconceptions was assessed with the Genetic Drift Inventory ... Here we present Genie, a browser-based educational tool that demonstrates population-genetic concepts such as genetic drift, ... Genie: an interactive real-time simulation for teaching genetic drift. Castillo, A. I., Roos, B. H., Rosenberg, M., Cartwright ... Genie was used to teach genetic drift to Evolution students at Arizona State University during Spring 2016 and Spring 2017. ...
... genetic drift has the effect of decreasing genetic variation within a population. For a more detailed explanation, see our ... genetic drift. Posted July 10, 2020. Random changes in the gene frequencies of a population from generation to generation. This ... genetic variation. Posted July 11, 2020. Loosely, a measure of the genetic differences there are within populations or species ... This process causes gene frequencies in a population to drift around over time. Some genes may even "drift out" of a population ...
Next-generation sequencing has provided a snapshot of the genetic landscape of most cancer types, and cancer genomics ... Genetic drift. A stochastic process that changes subclone frequency.. Selection. A non-random process shaped by environmental ... Genetic drift, selection and the evolution of the mutation rate. Nat. Rev. Genet. 17, 704-714 (2016). ... Resolving genetic heterogeneity in cancer. *Samra Turajlic1,2 na1, *Andrea Sottoriva ORCID: orcid.org/0000-0001-6709-95333 na1 ...
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What is Genetic Drift?. Genetic drift is a fundamental concept in animal biology that refers to the random fluctuations in ... Applications of Genetic Drift in Animal Breeding. While genetic drift is a random process, it can have significant implications ... The table below provides an overview comparing key features of both genetic drift and natural selection:. Genetic Drift. ... Applications of Genetic Drift in Animal Breeding. Genetic Drift in Animal Biology: Its Role in Animal Breeding and Genetics ...
... where its frequent lineage-specific expansions and contractions provide an excellent model to assess how genetic variation ... Epigenomic programming contributes to the genomic drift evolution of the F-Box protein superfamily in Arabidopsis Proc Natl ... whose emergences are consistent with genomic drift evolution. Here, we examined this variance within Arabidopsis thaliana by ... suppressing the adverse effects of gene dosage imbalance and harmful FBX alleles that arise during genomic drift, while ...
Continental Drift? Do European Clinical Genetic Testing Laboratories Have a Patent Problem? European Journal of Human Genetics ...
Genie: an interactive real-time simulation for teaching genetic drift. Castillo, A. I., Roos, B. H., Rosenberg, M. S., ... Additional file 14 of Genie: an interactive real-time simulation for teaching genetic drift. *Andreina I. Castillo (Creator) ... an interactive real-time simulation for teaching genetic drift. Figshare. 10.6084/m9.figshare.19211644.v1 ...
To determine whether Hills Ne based on these Vk• values accurately predicted the rate of genetic drift, two common genetic ... Along each simulated pedigree, genetic variation is tracked at a number of loci, and the rates of genetic drift are quantified ... The expected variance in allele frequency (Vp(t)) after t generations of genetic drift is (Hedrick 2000): where p0 is the ... Expected rates of genetic drift were computed using Equations 5 and 6 and the harmonic mean pedigree Ne for this scenario ( ...
How much of the genetic differences between humans and chimpanzees are due to genetic drift?. Ask Question ... How much of the genetic differences between humans and chimpanzees are due to genetic drift?. , I would answer: More than 60%! ... Have a look to why-is-the-strength-of-genetic-drift-inversely-proportional-to-the-population-size. $\endgroup$ - Remi.b ... begingroup$ @Rodrigo The loss of polymorphism through time (which is how one would quantify the concept of genetic drift) is ...
4. Genetic drift. 5. Phylogenetics. 6. Major theories for the origin of novel genes. 7. Nature and basis of codon bias ...
Genetic Drift. Posted on July 18, 2016 by hageyt This Evolution 101 post is by MSU grad student Ali Tehrani Darwinian evolution ... Posted in Evolution 101 , Tagged Biological Evolution, Evolution 101 , Comments Off on Genetic Drift ... Evolutionary Applications Evolutionary Computation experimental evolution Field Biology fitness fitness landscapes genetic ...
Learning mitigates genetic drift. Lenart P, Bienertová-Vašků J, Berec L. Lenart P, et al. Among authors: bienertova vasku j. ...
Genetic drift‎ (3 C, 36 F). H. *. Helping behavior‎ (47 F). *. Homology‎ (1 C, 1 P, 42 F) ...
Notes on genetic drift are posted. The video from 21 September is posted (but it doesnt have audio). Ive posted the notes on ... Notes on genetic drift are posted. The video from 21 September is posted (but it doesnt have audio) ... Lecture notes genetic structure with individual assignment posted. Ive posted the lecture notes for analysis of genetic ... genetic drift. Well be covering a lot of pretty complicated stuff this week. I encourage you to take a look at the notes ...
... genetic drift; concepts of species and other biological populations; genomics applied to taxonomy and systematics; the ...
Explain how mutation, migration, genetic drift, and natural selection affect evolutionary processes. Provide a specific example ... Explain how mutation, migration, genetic drift, and natural selection affect evolutionary processes. Provide a specific example ... genetic drift, and natural selection affect evolutionary processes. Provide a specific example for each. Please NO plagiarism. ...
  • Genetic drift may cause gene variants to disappear completely and thereby reduce genetic variation. (wikipedia.org)
  • This fluctuation is analogous to genetic drift - a change in the population's allele frequency resulting from a random variation in the distribution of alleles from one generation to the next. (wikipedia.org)
  • Genetic drift also reduces the genetic variation in a population. (tsijournals.com)
  • The accumulation of somatic genetic variation in clonal species undergoing asexual (or clonal) reproduction may lead to phenotypic heterogeneity among autonomous modules (termed ramets). (abo.fi)
  • However, the abundance and dynamics of somatic genetic variation under clonal reproduction remain poorly understood. (abo.fi)
  • By studying inter-ramet somatic genetic variation, we uncovered thousands of single nucleotide polymorphisms that segregated among ramets. (abo.fi)
  • Ultra-deep resequencing of single ramets revealed that the strength of purifying selection on mosaic genetic variation was greater within than among ramets. (abo.fi)
  • Understanding the concept of genetic variation. (brightstorm.com)
  • Whereas previous work has concentrated mainly on differences in selection regimes and selection pressures, we hypothesize that differences in genetic drift may explain some of this variation. (unifr.ch)
  • Together, these results suggest that the evolution of lifespan and ageing can be strongly affected by genetic drift, especially in small populations, and that variation in lifespan and ageing may often be nonadaptive, due to a strong contribution from mutation accumulation. (unifr.ch)
  • But the genetic drift creates zero variation. (slideshare.net)
  • Genetic variation is the raw material for evolution. (csbsju.edu)
  • Population recovered to 30,000, however in 24 gene loci tested, there is no genetic variation. (csbsju.edu)
  • Genetic variability in a population does not inevitably increase with time, since it is the result of factors acting in opposite directions: some processes introduce new variation in the populations while others remove it (Figure 2). (medscape.com)
  • Two main processes deplete variation from viral populations: selection and drift. (medscape.com)
  • Second, the opposite form of action is known as positive selection: it favors a new mutant that rises in frequency at the expense of other, less fit variants, leading to a temporary reduction of genetic variation in the population. (medscape.com)
  • Finally, the third form of action of natural selection at the molecular level actually contributes to and promotes increased levels of genetic variation. (medscape.com)
  • In the former case, the reduction in genetic variability is almost imperceptible and it is easily compensated by the continuous generation of new genetic variation. (medscape.com)
  • Although usually overlooked, if not ignored, in the study of genetic variation in viruses, the neutral theory of molecular evolution sustains that most variation found at the molecular level does not have an impact on viral fitness and, as a consequence, is neutral in terms of natural selection. (medscape.com)
  • So, what are the sources of new genetic variants - i.e., genetic variation ? (berkeley.edu)
  • As a species, cheetahs have famously low levels of genetic variation . (moviecultists.com)
  • Habitat encroachment and poaching have further reduce cheetah numbers, consequently snuffing out even more genetic variation and leaving cheetahs even more vulnerable to extinction. (moviecultists.com)
  • This results in one litter sired by different fathers and thus increases the genetic variation from cub to cub. (moviecultists.com)
  • Thanks to genetic variation, some were born with less hair. (scienceline.org)
  • Explanations for the genetic version ubiquitous in herbal populations are regularly labelled with the resource of using the populace-genetic techniques they emphasize: herbal choice or mutation and genetic waft. (ashdin.com)
  • As expected, the quantity of genetic version as compared to previous fashions that disregarded the stochastic results of waft become reduced, mainly for smaller populations and whilst spatial shape become maximum profound. (ashdin.com)
  • Unequal numbers of person males and females, multiplied variance in personal circle of relative's size, and temporal fluctuations in N all-purpose Ne to be an lousy lot a whole lot less than the census size, N. In many endangered populations Ne is best 10-30, and at such ranges genetic version turns into vast for a populace's viability. (ashdin.com)
  • We develop a model to formalize this idea and show that the strong positive relationship between lifespan and genetic diversity predicted by this model indeed exists among populations of Daphnia magna, and that ageing is accelerated in small populations. (unifr.ch)
  • Additional results suggest that this is due to increased drift in small populations rather than adaptation to environments favoring faster life histories. (unifr.ch)
  • rather, all investigated traits show clear signs of increased genetic load in the small populations. (unifr.ch)
  • and (3) for populations whose time of colonization is known, that the rate of morphological change is sufficiently slow to be accounted for solely by genetic drift. (bioone.org)
  • Nevertheless, limited genetic studies have been performed in Afghan populations. (nih.gov)
  • In this study, 17 Y-chromosomal short tandem repeat (Y-STR) loci were typed to evaluate their forensic and population genetic applications in 189 unrelated Afghan males geographically partitioned along the Hindu Kush Mountain range into north (N=44) and south (N=145) populations. (nih.gov)
  • Again, genetic drift means small and isolated but those populations have to mate with their close relative and produced homozygous organisms. (slideshare.net)
  • Thus, small populations and isolated populations (i.e. genetic drift) are opposite to any kind of evolution, even risk for extinction. (slideshare.net)
  • However, genetic drift is also the key force of Neutral theory, which works in smalls and isolated populations. (slideshare.net)
  • By increasing the proportion of viral particles that carry particular high-fitness variants, selection may transitorily reduce genetic variability in populations, while the effect of drift is continuous and affects all variants equally in the population, regardless of their effect on the viral fitness. (medscape.com)
  • All of these mechanisms can cause changes in the frequencies of genes and other genetic elements in populations, and so all of them are mechanisms of evolutionary change. (berkeley.edu)
  • Genetic drift leads to fixation of alleles or genotypes in populations. (moviecultists.com)
  • Drift is probably common in populations that undergo regular cycles of extinction and recolonization. (moviecultists.com)
  • Migration is a powerful force acting against genetic divergence among sub-populations (Hartl & Clark, Principles of Population Genetics, pp. 295-309). (blogspot.com)
  • Wherever direct sunlight was scarce, populations became paler - something Jablonski calls genetic "fine-tuning. (scienceline.org)
  • 1. Natural selection, mutation, genetic drift, and gene flow drive the process of evolution. (visiblebody.com)
  • Natural selection, mutation, genetic drift, and gene flow (gene migration) all contribute to changes in allele frequencies. (visiblebody.com)
  • Mutation results in the introduction of new genes and is the ultimate source of new genetic information. (csbsju.edu)
  • In the process of substitution, a previously non-existent allele arises by mutation and undergoes fixation by spreading through the population by random genetic drift and/or positive selection. (blogspot.com)
  • Genetic change brought about by mutation or recombination is, in essence, random, and therefore many genes exist as a range of variants, or alleles, in any population. (gresham.ac.uk)
  • The main evolutionary forces mutation, genetic drift, migration and selection all affected the genetic diversity observed today. (unifr.ch)
  • The genomes of contemporary humans were shaped by evolutionary forces, such as mutation, selection, migration, and genetic drift. (nih.gov)
  • Ronald Fisher, who explained natural selection using Mendelian genetics, held the view that genetic drift plays at most a minor role in evolution, and this remained the dominant view for several decades. (wikipedia.org)
  • In 1968, population geneticist Motoo Kimura rekindled the debate with his neutral theory of molecular evolution, which claims that most instances where a genetic change spreads across a population (although not necessarily changes in phenotypes) are caused by genetic drift acting on neutral mutations. (wikipedia.org)
  • Based on higher-depth re-sequenced data from a subset of these initially sequenced samples (260 samples from 168 pigs), we characterized patterns of within-host IAV genetic diversity and evolution. (nih.gov)
  • Ronald Fisher, who defined herbal choice the utilization of Mendelian genetics, held the view that genetic waft performs at maximum a minor function in evolution, and this remained the dominant view for numerous decades. (ashdin.com)
  • In 1968, populace geneticist Motoo Kimura rekindled the talk collectively in conjunction with his impartial concept of molecular evolution, which claims that maximum times in which a genetic alternate spreads throughout a populace (even though now no longer always adjustments in phenotypes) are ensuing from genetic waft appearing on impartial mutations. (ashdin.com)
  • 12: The evolution of genetic systems. (freepdfbook.com)
  • Here we show that branching events in a seagrass (Zostera marina) clone or genet lead to population bottlenecks of tissue that result in the evolution of genetically differentiated ramets in a process of somatic genetic drift. (abo.fi)
  • Hence, evolutionary biologists rejected genetic drift for any kind of evolution. (slideshare.net)
  • Many of these differences in DNA appear to reflect random 'genetic drift' throughout evolution. (nih.gov)
  • All multicellular organisms are genetic mosaics owing to somatic mutations. (abo.fi)
  • 3. Mutations increase genetic diversity in a population. (visiblebody.com)
  • In summary, evolutionists believe that the source of new genetic information is mutations sorted by natural selection-the neo-Darwinian theory. (creation.com)
  • [ 10 , 11 ] Stochastic processes, usually associated with genetic drift, will dominate the fate of these mutations if effective population size is lower than the reciprocal of the corresponding selection coefficients. (medscape.com)
  • First, the correlation between genetic diversity and lifespan remains significant after statistical correction for potential environmental covariates. (unifr.ch)
  • U.S. soybean breeding programs are widely recognized as limited by insufficient genetic diversity. (farmprogress.com)
  • In the process of developing modern soybean varieties for U.S. farmers, the first generations of U.S. soybean breeders (~1930-1990) essentially ignored genetic diversity. (farmprogress.com)
  • The second reason is that the diversity in this initial narrow genetic base has been reduced further as a victim of its own successful breeding. (farmprogress.com)
  • They went through a "Genetic Bottleneck", and their genetic diversity plummeted. (moviecultists.com)
  • How do cheetahs increase genetic diversity? (moviecultists.com)
  • Dr. Tishkoff has conducted ground-breaking research on African genetic diversity and the genetic basis of adaptation in humans. (nih.gov)
  • Genetic drift, also known as random genetic drift, allelic drift or the Wright effect, is the change in the frequency of an existing gene variant (allele) in a population due to random chance. (wikipedia.org)
  • This multiplied quantity of genetic version is due to the fact of the advent of barely deleterious alleles with the resource of using genetic waft and this technique is greater green whilst migration load is better. (ashdin.com)
  • Drift increases the inbreeding coefficient and increases homozygosity as a result of removing alleles. (moviecultists.com)
  • Based on the 11 LTL-associated alleles and genetic data in phase 3 of the 1000 Genomes Project, we show that the shifts in allele frequency within Europe and between Europe and Africa do not fit the pattern expected by neutral genetic drift. (nih.gov)
  • When few copies of an allele exist, the effect of genetic drift is more notable, and when many copies exist, the effect is less notable. (wikipedia.org)
  • The incorporation of genetic waft additionally selects for health units that display off allele-frequency equilibria with large area names of attraction: they are "greater stable. (ashdin.com)
  • When few copies of an allele exist, the impact of genetic waft is greater notable, and whilst many copies exist, the impact is a whole lot less notable. (ashdin.com)
  • Genetic drift can be defined as a change in the frequency of allele that is random instead of being driven by selection pressures. (tsijournals.com)
  • 16. Genetic anthropology of the colorectal cancer-susceptibility allele APC I1307K: evidence of genetic drift within the Ashkenazim. (nih.gov)
  • Balance of forces acting on HCV genetic variability. (medscape.com)
  • This form is known as purifying or negative selection and it has a moderate effect in reducing genetic variability, because it will mainly eliminate the negative variants, and those associated with them in the same genomic molecule. (medscape.com)
  • By contrast, extreme reductions in population size, especially during the transmission from one infected host to a new one (or after liver transplantation), result in a drastic elimination of genetic variability after which only a few of the initially present variants are represented in the newly established population (Figure 3). (medscape.com)
  • Effects of genetic drift on HCV genetic variability. (medscape.com)
  • Cheetahs are virtual clones , with only one to 10 percent of the genetic variability found in other feline species [source: Begley]. (moviecultists.com)
  • The expert panels noted the lack of standardized genetic rat models of hypertension due to independent breeding and the absence of appropriate inbred controls, and assessed the extent to which phenotypic and genotypic variability among genetic rat models of hypertension is impeding research in the field. (nih.gov)
  • Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants. (nature.com)
  • Somatic genetic drift during clonal propagation leads to the emergence of genetically unique modules that constitute an elementary level of selection and individuality in long-lived clonal species. (abo.fi)
  • Leukocyte telomere length (LTL), which reflects telomere length in other somatic tissues, is a complex genetic trait. (nih.gov)
  • Population genetics can contribute to our understanding of human health by characterizing the genetic makeup of humans, the evolutionary forces that shaped these, and by studying the evolutionary forces acting on human pathogens. (unifr.ch)
  • There are two types of genetic drift. (onlyprofessors.com)
  • Comparisons between samples collected in 2014 (by this project) and 25 years ago (by a previous project) and among types of genetic markers suggests that gemfish stocks are experiencing pronounced genetic drift. (molecularfisherieslaboratory.com.au)
  • The process of genetic drift can be illustrated using 20 marbles in a jar to represent 20 organisms in a population. (wikipedia.org)
  • The genetic drift rapidly works in a small and isolated population and not works in a large population. (slideshare.net)
  • Hence, genetic drift means small and isolated population and vice-versa. (slideshare.net)
  • Genetic drift is essentially due to a sampling error - the small population doesn't reflect the allelic frequency of the whole. (csbsju.edu)
  • Genetic drift is the result of the sampling process that occurs in every population in which the total number of individuals is limited. (medscape.com)
  • Genetic drift acts in every population with a finite population size, but its effects are more intense the smaller the number of individuals giving rise to the next generation. (medscape.com)
  • The founder effect is particularly common on islands, where the original colonising population of a plant or animal may have consisted of only a handful of individuals, washed up on drifting vegetation, for instance. (gresham.ac.uk)
  • 3) Process of natural selection in a finite population (interaction between selection and random genetic drift). (projecteuclid.org)
  • 4. Clinical and genetic findings in an Ashkenazi Jewish population with colorectal neoplasms. (nih.gov)
  • In addition, this effort is necessary to avoid unwanted genetic heterogeneity in particular strains. (nih.gov)
  • The panels commented that genetic heterogeneity can compromise the scientific value of many studies and can lead to wasteful and inefficient experiments that render inter-laboratory comparisons difficult. (nih.gov)
  • But it can also occur in the absence of geographical isolation - the founder effect requires only genetic isolation, not physical separation. (gresham.ac.uk)
  • In the middle of the 20th century, vigorous debates occurred over the relative importance of natural selection versus neutral processes, including genetic drift. (wikipedia.org)
  • However, the genetic drift represents the punctuated equilibrium, the shifting balance theory, the allopatric speciation theory and the species selection theory for the macroevolution. (slideshare.net)
  • By contrast, however, for better ranges of gene drift and large populace sizes, the quantity of genetic version located after many generations become extra than that during simulations without waft. (ashdin.com)
  • The amount of genetic difference between them is unusually large for a marine fish species. (molecularfisherieslaboratory.com.au)
  • Here we utilize natural repeated island colonization events by members of the avian species complex, Zosterops lateralis , to assess whether or not genetic drift alone is an adequate explanation for the observed patterns of microevolutionary divergence in morphology. (bioone.org)
  • Tiny genetic changes result in tiny biological changes which lead to tiny advantages in the struggle for survival and ultimately, over millennia, to the appearance of new species. (gresham.ac.uk)
  • 2. Genetic analyses in consecutive israeli jewish colorectal cancer patients. (nih.gov)
  • It is considered an autosomal dominant condition, but almost all cases are the result of de novo genetic changes and occur in people with no family history of the condition. (nih.gov)
  • Li L, Fu L, Zhang L, Feng Y. Mendelian randomization study of the genetic interaction between psoriasis and celiac disease. (nature.com)
  • My questions concern the assumptions of these models, the existence of other models of genetic drift, explanation of the advantage/disadvantage of these models and the empirical results supporting one or another model. (stackexchange.com)
  • The chances that frequency of red and white marbles that you poured out reflects the genetic composition of the whole is small. (csbsju.edu)
  • In recent years, genome-wide association studies (GWAS) have been instrumental in unraveling the genetic architecture of complex diseases, including psoriasis. (nature.com)
  • Pedigree Dogs Exposed Nature - 60 min - ★ 8.19 Pedigree dogs are suffering from genetic diseases. (topdocumentaryfilms.com)
  • GeneReviews provides scientific information on genetic diseases, including diagnosis, treatment, and genetic counseling. (nih.gov)
  • RESEARCH OBJECTIVES Summary This supplement program will allow unique and valuable rat strains to be preserved so that both existing and newly developed models of hypertension, including those derived from traditional breeding techniques as well as molecular genetic technologies, will be available to investigators for future use. (nih.gov)
  • There two main mathematical models to describe the process of genetic drift are Moran model and Wright-Fisher model. (stackexchange.com)
  • For this to have worked, there must be some process which can generate the genetic information in living things today. (creation.com)
  • The mechanisms of genetic drift can be illustrated with a simplified example. (wikipedia.org)
  • Autosomal dominant is a pattern of inheritance characteristic of some genetic disorders. (genome.gov)
  • Autosomal recessive is a pattern of inheritance characteristic of some genetic disorders. (genome.gov)
  • Genetic inheritance. (topdocumentaryfilms.com)
  • Since the behaviors they exhibit do not confer survival value, scientists attribute the delegation'ê s existence to a phenomenon known as 'ê genetic drift. (crosscut.com)
  • This disease is caused by a change in the genetic material (DNA). (nih.gov)
  • Genetic drift at expanding frontiers promotes gene segregation. (mpg.de)
  • During a study of rodentborne analysis ( 2 ) and the impracticality and trophoresis as a tool for determining the hemorrhagic fever viruses performed degree of genetic relatedness between expense of better performing tech- in Guinea in 2002-2004, 32 shrews of strains of Escherichia coli O157:H7. (cdc.gov)