Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Microarray Analysis: The simultaneous analysis, on a microchip, of multiple samples or targets arranged in an array format.Cluster Analysis: A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.Gene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Transcriptome: The pattern of GENE EXPRESSION at the level of genetic transcription in a specific organism or under specific circumstances in specific cells.Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.Gene Expression Regulation, Developmental: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Microdissection: The performance of dissections with the aid of a microscope.Up-Regulation: A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Cell Line, Tumor: A cell line derived from cultured tumor cells.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Gene Expression Regulation, Plant: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in plants.RNA: A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)Expressed Sequence Tags: Partial cDNA (DNA, COMPLEMENTARY) sequences that are unique to the cDNAs from which they were derived.Gene Regulatory Networks: Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Down-Regulation: A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Real-Time Polymerase Chain Reaction: Methods used for detecting the amplified DNA products from the polymerase chain reaction as they accumulate instead of at the end of the reaction.MicroRNAs: Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.DNA, Complementary: Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Computational Biology: A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Genomics: The systematic study of the complete DNA sequences (GENOME) of organisms.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Genes, Neoplasm: Genes whose abnormal expression, or MUTATION are associated with the development, growth, or progression of NEOPLASMS.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Principal Component Analysis: Mathematical procedure that transforms a number of possibly correlated variables into a smaller number of uncorrelated variables called principal components.Mice, Inbred C57BLCell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Validation Studies as Topic: Research using processes by which the reliability and relevance of a procedure for a specific purpose are established.Gene Expression Regulation, Bacterial: Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.RNA, Neoplasm: RNA present in neoplastic tissue.Tissue Fixation: The technique of using FIXATIVES in the preparation of cytologic, histologic, or pathologic specimens for the purpose of maintaining the existing form and structure of all the constituent elements.Breast Neoplasms: Tumors or cancer of the human BREAST.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.In Situ Hybridization: A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.DNA Primers: Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Gene Expression Regulation, Enzymologic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.Multigene Family: A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)Toxicogenetics: The study of existing genetic knowledge, and the generation of new genetic data, to understand and thus avoid DRUG TOXICITY and adverse effects from toxic substances from the environment.Protein Array Analysis: Ligand-binding assays that measure protein-protein, protein-small molecule, or protein-nucleic acid interactions using a very large set of capturing molecules, i.e., those attached separately on a solid support, to measure the presence or interaction of target molecules in the sample.Gene Library: A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Paraffin Embedding: The infiltrating of tissue specimens with paraffin, as a supporting substance, to prepare for sectioning with a microtome.Neoplasm Proteins: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Genome, Human: The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Organ Specificity: Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Gene Expression Regulation, Fungal: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in fungi.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Gene Expression Regulation, Viral: Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.Gene Ontology: Sets of structured vocabularies used for describing and categorizing genes, and gene products by their molecular function, involvement in biological processes, and cellular location. These vocabularies and their associations to genes and gene products (Gene Ontology annotations) are generated and curated by the Gene Ontology Consortium.Gene Expression Regulation, Leukemic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in leukemia.Lasers: An optical source that emits photons in a coherent beam. Light Amplification by Stimulated Emission of Radiation (LASER) is brought about using devices that transform light of varying frequencies into a single intense, nearly nondivergent beam of monochromatic radiation. Lasers operate in the infrared, visible, ultraviolet, or X-ray regions of the spectrum.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Models, Genetic: Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Chromatin Immunoprecipitation: A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.Blotting, Northern: Detection of RNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.Genome: The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.Repressor Proteins: Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.Nucleic Acid Hybridization: Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)Cell Cycle: The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.Nuclear Proteins: Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.Genes, Plant: The functional hereditary units of PLANTS.RNA, Small Interfering: Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.Laser Capture Microdissection: Techniques using a laser to cut away and harvest a specific cell or cluster of cells from a tissue section while viewing it under the microscope.Genes, Reporter: Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.Homeodomain Proteins: Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL).Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.Trans-Activators: Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.Tissue Array Analysis: The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.Lymphoma, Large B-Cell, Diffuse: Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.Fibroblasts: Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.Proteomics: The systematic study of the complete complement of proteins (PROTEOME) of organisms.RNA Interference: A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.Transcriptional Activation: Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Formaldehyde: A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717)Sequence Analysis, RNA: A multistage process that includes cloning, physical mapping, subcloning, sequencing, and information analysis of an RNA SEQUENCE.Epithelial Cells: Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.DNA Methylation: Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.Stress, Physiological: The unfavorable effect of environmental factors (stressors) on the physiological functions of an organism. Prolonged unresolved physiological stress can affect HOMEOSTASIS of the organism, and may lead to damaging or pathological conditions.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Arabidopsis: A plant genus of the family BRASSICACEAE that contains ARABIDOPSIS PROTEINS and MADS DOMAIN PROTEINS. The species A. thaliana is used for experiments in classical plant genetics as well as molecular genetic studies in plant physiology, biochemistry, and development.Molecular Sequence Annotation: The addition of descriptive information about the function or structure of a molecular sequence to its MOLECULAR SEQUENCE DATA record.Metabolic Networks and Pathways: Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Gene Silencing: Interruption or suppression of the expression of a gene at transcriptional or translational levels.Epigenesis, Genetic: A genetic process by which the adult organism is realized via mechanisms that lead to the restriction in the possible fates of cells, eventually leading to their differentiated state. Mechanisms involved cause heritable changes to cells without changes to DNA sequence such as DNA METHYLATION; HISTONE modification; DNA REPLICATION TIMING; NUCLEOSOME positioning; and heterochromatization which result in selective gene expression or repression.Genetic Markers: A phenotypically recognizable genetic trait which can be used to identify a genetic locus, a linkage group, or a recombination event.Proteome: The protein complement of an organism coded for by its genome.Cell Lineage: The developmental history of specific differentiated cell types as traced back to the original STEM CELLS in the embryo.RNA, Plant: Ribonucleic acid in plants having regulatory and catalytic roles as well as involvement in protein synthesis.High-Throughput Nucleotide Sequencing: Techniques of nucleotide sequence analysis that increase the range, complexity, sensitivity, and accuracy of results by greatly increasing the scale of operations and thus the number of nucleotides, and the number of copies of each nucleotide sequenced. The sequencing may be done by analysis of the synthesis or ligation products, hybridization to preexisting sequences, etc.Gene Dosage: The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Embryo, Mammalian: The entity of a developing mammal (MAMMALS), generally from the cleavage of a ZYGOTE to the end of embryonic differentiation of basic structures. For the human embryo, this represents the first two months of intrauterine development preceding the stages of the FETUS.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Plant Proteins: Proteins found in plants (flowers, herbs, shrubs, trees, etc.). The concept does not include proteins found in vegetables for which VEGETABLE PROTEINS is available.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Chromosome Mapping: Any method used for determining the location of and relative distances between genes on a chromosome.Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.Gene Knockdown Techniques: The artificial induction of GENE SILENCING by the use of RNA INTERFERENCE to reduce the expression of a specific gene. It includes the use of DOUBLE-STRANDED RNA, such as SMALL INTERFERING RNA and RNA containing HAIRPIN LOOP SEQUENCE, and ANTI-SENSE OLIGONUCLEOTIDES.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.RNA, Complementary: Synthetic transcripts of a specific DNA molecule or fragment, made by an in vitro transcription system. This cRNA can be labeled with radioactive uracil and then used as a probe. (King & Stansfield, A Dictionary of Genetics, 4th ed)Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Prostatic Neoplasms: Tumors or cancer of the PROSTATE.Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.Reference Standards: A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy.Neoplasms, Plasma Cell: Neoplasms associated with a proliferation of a single clone of PLASMA CELLS and characterized by the secretion of PARAPROTEINS.Gene Deletion: A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.Embryonic Stem Cells: Cells derived from the BLASTOCYST INNER CELL MASS which forms before implantation in the uterine wall. They retain the ability to divide, proliferate and provide progenitor cells that can differentiate into specialized cells.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Genes, Developmental: Genes that determine the fate of a cell or CELLS in a region of the embryo during EMBRYONIC DEVELOPMENT.Biomarkers, Pharmacological: Measurable biological parameters that serve for drug development, safety and dosing (DRUG MONITORING).Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Wnt Proteins: Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. They bind to FRIZZLED RECEPTORS and act as PARACRINE PROTEIN FACTORS to initiate a variety of SIGNAL TRANSDUCTION PATHWAYS. The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN.Muscle, Skeletal: A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.Luciferases: Enzymes that oxidize certain LUMINESCENT AGENTS to emit light (PHYSICAL LUMINESCENCE). The luciferases from different organisms have evolved differently so have different structures and substrates.Leukocytes, Mononuclear: Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.Histones: Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each.NF-kappa B: Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.Stem Cells: Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Neoplasm Invasiveness: Ability of neoplasms to infiltrate and actively destroy surrounding tissue.Cell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.Lung Neoplasms: Tumors or cancer of the LUNG.Comparative Genomic Hybridization: A method for comparing two sets of chromosomal DNA by analyzing differences in the copy number and location of specific sequences. It is used to look for large sequence changes such as deletions, duplications, amplifications, or translocations.Quantitative Trait Loci: Genetic loci associated with a QUANTITATIVE TRAIT.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Cytokines: Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.DNA Probes: Species- or subspecies-specific DNA (including COMPLEMENTARY DNA; conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32P and 125I and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.RNA Stability: The extent to which an RNA molecule retains its structural integrity and resists degradation by RNASE, and base-catalyzed HYDROLYSIS, under changing in vivo or in vitro conditions.Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.Arabidopsis Proteins: Proteins that originate from plants species belonging to the genus ARABIDOPSIS. The most intensely studied species of Arabidopsis, Arabidopsis thaliana, is commonly used in laboratory experiments.Host-Pathogen Interactions: The interactions between a host and a pathogen, usually resulting in disease.Postmortem Changes: Physiological changes that occur in bodies after death.Bacterial Proteins: Proteins found in any species of bacterium.Drug Resistance, Neoplasm: Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Oxidative Stress: A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).Zebrafish: An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.Lymphoma, B-Cell: A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.Paraffin: A mixture of solid hydrocarbons obtained from petroleum. It has a wide range of uses including as a stiffening agent in ointments, as a lubricant, and as a topical anti-inflammatory. It is also commonly used as an embedding material in histology.Oncogenes: Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene.Genome, Plant: The genetic complement of a plant (PLANTS) as represented in its DNA.Mice, Inbred BALB CMetabolome: The dynamic collection of metabolites which represent a cell's or organism's net metabolic response to current conditions.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Oryza sativa: Annual cereal grass of the family POACEAE and its edible starchy grain, rice, which is the staple food of roughly one-half of the world's population.Response Elements: Nucleotide sequences, usually upstream, which are recognized by specific regulatory transcription factors, thereby causing gene response to various regulatory agents. These elements may be found in both promoter and enhancer regions.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Single-Cell Analysis: Assaying the products of or monitoring various biochemical processes and reactions in an individual cell.Liver Neoplasms: Tumors or cancer of the LIVER.Embryonic Development: Morphological and physiological development of EMBRYOS.Proto-Oncogene Proteins: Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.Genome-Wide Association Study: An analysis comparing the allele frequencies of all available (or a whole GENOME representative set of) polymorphic markers in unrelated patients with a specific symptom or disease condition, and those of healthy controls to identify markers associated with a specific disease or condition.Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.Nerve Tissue ProteinsFrozen Sections: Thinly cut sections of frozen tissue specimens prepared with a cryostat or freezing microtome.Neoplasms, Basal Cell: Neoplasms composed of cells from the deepest layer of the epidermis. The concept does not refer to neoplasms located in the stratum basale.Cell Culture Techniques: Methods for maintaining or growing CELLS in vitro.In Situ Hybridization, Fluorescence: A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.Regulatory Elements, Transcriptional: Nucleotide sequences of a gene that are involved in the regulation of GENETIC TRANSCRIPTION.Hepatocytes: The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.Plasma Cells: Specialized forms of antibody-producing B-LYMPHOCYTES. They synthesize and secrete immunoglobulin. They are found only in lymphoid organs and at sites of immune responses and normally do not circulate in the blood or lymph. (Rosen et al., Dictionary of Immunology, 1989, p169 & Abbas et al., Cellular and Molecular Immunology, 2d ed, p20)Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.Cell Movement: The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.

*  Effect of Iressa With/Without Concurrent Chemoradiotherapy on Tumor Gene Expression Profiles in Pati
on Tumor Gene Expression Profiles in Patients With Advanced Non- ... on Tumor Gene Expression Profiles in Patients With Advanced Non- ... ZD1839 on Tumour Gene Expression Profiles. Criteria Inclusion...
https://clinicaltrials.gov/ct2/show/NCT00228488
*  Batch or Gravity Flow Purification of His-Tagged Proteins
RNA-Seq. Mouse TCR Profiling. Human TCR Profiling. ChIP-Seq Library ... Torrent. Human TCR Profiling Kit. Mouse TCR Profiling Kit. Library ... Construction Kits. Gene Expression Profiling. ExpressHyb...
http://clontech.com/US/Products/Protein_Expression_and_Purification/His-Tagged_Protein_Purification/Cobalt_Resin-Batch?sitex=10020:22372:US&PROD=sSQzRGCheTiiqxr04MtpMrZU:S&PROD_pses=ZG6A265D97D60F51FF0912C95B5A6AF67E2AC5A68379B4496084F8EE658ADDA8AB9626D28BDAEFE941597FB7347BC6BA33DB10FA711C82AC25
*  Fluorescent Protein Vectors for Labeling and Transfection Control
RNA-Seq. Mouse TCR Profiling. Human TCR Profiling. ChIP-Seq Library ... Torrent. Human TCR Profiling Kit. Mouse TCR Profiling Kit. Library ... Construction Kits. Gene Expression Profiling. ExpressHyb...
http://clontech.com/US/Products/Fluorescent_Proteins_and_Reporters/Fluorescent_Proteins/Transfection_Controls?sitex=10020:22372:US&PROD=rDzn1K4q4NJ5OW9WNRa2uHhA:S&PROD_pses=ZG3435A5A1D16B3C25A6868A2D4BE74CFBE04335E019FC72FFE883E59C6D22F12E8772A6B87A21955DFBFC9D502F97A21AF4F2E3C0033D59A6
*  Transcriptome analysis identifies stem cells and immune related genes in the cnidarian Hydractinia
and immune related genes in the cnidarian Hydractinia echinata ... and immune related genes in the cnidarian Hydractinia echinata ... amount of Expressed Sequence Tag EST and genomic data...
http://archiv.ub.uni-heidelberg.de/volltextserver/9667/
*  Fisher Scientific
RT; 50mL TaqMan Gene Expression MasterMix store at 4 C ; 2 ... RT; 5mL TaqMan Gene Expression MasterMix store at 4 C ; 265 ... workflow for gene expression analysis for samples containing 1 10...
https://fishersci.ca/shop/products/ambion-single-cell-to-ct-qrt-pcr-kit-2/p-4918777
*  Research Supported by the the PHA-AHA Fellowship A - Pulmonary Hypertension Association
hypertension field. Gene Expression Profiles in Patients with...
http://phassociation.org/page.aspx?pid=1298&chid=200
*  Molecular & Cellular Biology
Service. Next-Generation Sequencing. Genotyping. Gene Expression Profiling. Products. Antibodies. Clones...
http://lifesciences.sourcebioscience.com/molecular-cellular-biology/
*  Gene Network Central
... qiagen ... browse by epigenetics home resources gene ... visit geneglobe on qiagen website gene network central gncpro tutorial...
http://sabiosciences.com/genenetwork/genenetworkcentral.php?errtype=ND&protein=ENSG00000223793
*  Search Results | Academic Commons
1 item. 1 Gene expression profiling of human primary astrocytes...
http://academiccommons.columbia.edu/?f[department_facet][]=Center for Parkinson's Disease and Other Movement Disorders&f[author_facet][]=Zhou, Mei
*  bats – The Weizmann Wave
Garden of Science Gene expression profiles Genes Genetic ... Engineering Genetic tool Geophysics Gravity heart ... Science Blogs Go to. Life Science. Information Science. The Physics of Finding Food Posted by weizmann science writer on July 14, 2010. weizmann science writer on The puzzle of chemotherapy resistance. A360° Brain Games on Basic chemistry might keep brain cells healthy See Noevo on The puzzle of chemotherapy resistance Archives September 2015. complexity in biology Embryonic development Encryption Environment European Union Female health fMRI Forests Friction model Garden of Science Gene expression profiles Genes Genetic Engineering Genetic tool Geophysics Gravity heart disease Help for Disabled Higgs boson Immunology Inflammation Interface magazine International program International program Internet Inversment in Research Investing in Research Investing in the Future Lab equipment Laws of thermodynamics Leptin resistance LHC Library Life after retirement Lunar eclipse Man in the Moon Marathon...
http://scienceblogs.com/weizmann/tag/bats/
*  Gene expression profiling reveals early cellular responses to intracellular magnetic labeling with s
... uperparamagnetic iron oxide nanoparticles. - PubMed - NCBI Warning: The NCBI web site requires JavaScript to function. NCBI. BLAST Basic Local Alignment Search Tool. BLAST Stand-alone. BLAST Basic Local Alignment Search Tool. BLAST Stand-alone. Conserved Domain Search Service CD Search. Conserved Domain Search Service CD Search. All Genes Expression Resources... PubMed. PubMed Central PMC. Search database All Databases Assembly BioProject BioSample BioSystems Books ClinVar Clone Conserved Domains dbGaP dbVar Epigenomics EST Gene Genome GEO DataSets GEO Profiles GSS GTR HomoloGene MedGen MeSH NCBI Web Site NLM Catalog Nucleotide OMIM PMC PopSet Probe Protein Protein Clusters PubChem BioAssay PubChem Compound PubChem Substance PubMed PubMed Health SNP SRA Structure Taxonomy ToolKit ToolKitAll ToolKitBook UniGene Search term. 1 selected item: 20373404 Format Summary Summary text Abstract Abstract text MEDLINE XML PMID List. Gene expression profiling reveals early cellular responses to intracellular magnetic ...
http://ncbi.nlm.nih.gov/pubmed/20373404
*  High Throughput Gene Expression/Biomarker Core Laboratory | UMASS Medical School
High Throughput Gene Expression/Biomarker Core Laboratory. UMASS Medical School. Main Menu Home Page. Meet the Staff. Instrumentation. Possible Applications. Sample Submission. Rates. Why This Core. Utility Links. Open/Close Menu. Search. Advanced Search. Search. Advanced Search. HT Gene Expression. Skip Navigation. Home Page. Meet the Staff. Instrumentation. Possible Applications. Sample Submission. Rates. Why This Core. . Contact Us Co-Director: Kahraman Tanriverdi, PhD Phone: 508-856-6962 kahraman.tanriverdi@umassmed.edu www.umassmed.edu/htcore. High Throughput Gene Expression/Biomarker Core Laboratory. The High Throughput Gene Expression/Biomarker Core Laboratory run by Drs. Tanriverdi and Freedman provides High Throughput/Rapid Gene Expression and Complete miRNA profiling analysis by using gold standard qRT-PCR with the combination of custom Integrated Fluidic Circuit IFC technology from Fluidigm South San Francisco, CA. Also, high-throughput SNP and multi-plate immunoassay services are available. The co...
http://umassmed.edu/htcore
*  Gene expression profiling reveals reproducible human lung adenocarcinoma subtypes in multiple indepe
... ndent patient cohorts. Our Approach Areas of Focus History Leadership Who is Broad Partner Institutions Artist-in-Residence Media Center. Press Room News from the Broad Photos for Journalists Spotlight: Ebola Spotlight: CRISPR BroadMinded Blog Video Library For the Scientific Community. Scientific Publications Science Data Software. Scientific Publications Science Data Software. News & Publications:Scientific Publications Gene expression profiling reveals reproducible human lung adenocarcinoma subtypes in multiple independent patient cohorts. Read More / View Supplemental Materials. Scientific Publications Back to Publications Gene expression profiling reveals reproducible human lung adenocarcinoma subtypes in multiple independent patient cohorts. Tumor subtypes were distinguishable by many hundreds of genes, and lists generated in one cohort were predictive of tumor subtypes in the two other cohorts. Most notably, bronchioid tumors were correlated with improved survival in early-stage disease, whereas sq...
http://broadinstitute.org/publications/broad837
*  Genome-wide gene expression profiling and a forward genetic screen show that differential expression
... of the sodium ion transporter Ena21 contributes to the differential tolerance of Candida albicans and Candida dubliniensis to osmotic stress. . Home. Submit. Login. View Item. TARA. School of Dental Sciences. Dental Science. Dental Science Scholarly Publications. View Item. TARA. School of Dental Sciences. Dental Science. Dental Science Scholarly Publications View Item. JavaScript is disabled for your browser. Some features of this site may not work without it. Search TARA. This Collection. Advanced Search. Browse. All of TARA. Academic/Research Units Collections Titles Authors Date of Publication Subjects Sponsor This Collection. Titles Authors Date of Publication Subjects Sponsor. Statistics. View Google Analytics Statistics. Genome-wide gene expression profiling and a forward genetic screen show that differential expression of the sodium ion transporter Ena21 contributes to the differential tolerance of Candida albicans and Candida dubliniensis to osmotic stress. File Type:. PDF. Item Type:. Journal A...
http://tara.tcd.ie/xmlui/handle/2262/29626
*  ARS | Publication request: WHOLE-GENOME EXPRESSION PROFILING DEFINES THE HRPL REGULON OF PSEUDOMONAS
Publication request: WHOLE-GENOME EXPRESSION PROFILING DEFINES THE HRPL REGULON OF PSEUDOMONAS SYRINGAE PV. TOMATO DC3000, ALLOWS DE NOVO RECONSTRUCTION OF THE HRP CIS ELEMENT, AND IDENTIFIES NOVEL CO-REGULATED GENES ARS : Research. ARS Office of International Research Programs. Title: WHOLE-GENOME EXPRESSION PROFILING DEFINES THE HRPL REGULON OF PSEUDOMONAS SYRINGAE PV. TOMATO DC3000, ALLOWS DE NOVO RECONSTRUCTION OF THE HRP CIS ELEMENT, AND IDENTIFIES NOVEL CO-REGULATED GENES Authors. Whole-genome expression profiling defines the hrpl regulon of pseudomonas syringae pv. tomato dc3000, allows de novo reconstruction of the hrp cis element, and identifies novel co-regulated genes. tomato DC3000 is a model bacterial pathogen of tomato and Arabidopsis that deploys a type III secretion system a highly sophisticated secretion system used to introduce specific bacterial proteins called effectors into the plant host cells to disrupt plant cell defenses during pathogenesis. Accordingly, elucidation of the regulatory ...
https://ars.usda.gov/research/publications/publications.htm?SEQ_NO_115=196114
*  High Throughput Gene Expression | Possible Application | UMASS Medical School
High Throughput Gene Expression. Meet the Staff. Advanced Search. Advanced Search. HT Gene Expression. Meet the Staff. HT Gene Expression. Contact Us Co-Director: Kahraman Tanriverdi, PhD Phone: 508-856-6962 kahraman.tanriverdi@umassmed.edu www.umassmed.edu/htcore. HT Gene Expression. Possible Applications High-Throughput Gene Expression Analysis. Ninety-six samples can be analyzed for 96 gene expression assays in under 3 hours. Standard TaqMan SNP assays or your own primers can be used. Users may also choose to submit their genes for DELTAgene assay design service provided by Fluidigm. High-Throughput miRNA Profiling. Ninety-six or more samples can be analyzed for any miRNA assay or entire miRNA assay library 1,801 miRNA Assays in 1-5 business days. Qiagen miScript miRNA assays are provided by core. High-Throughput miRNA Inhibitor Mimic Transfection. Up to 96 miRNA inhibitor or mimic at a time can be transfected to desired cell line and up to 96 gene expression level can be analyzed in a few days with low co...
http://umassmed.edu/htcore/possible_applications/
*  High Throughput Gene Expression | Instrumentation | UMASS Medical School
High Throughput Gene Expression. Instrumentation. Meet the Staff. Instrumentation. Advanced Search. Advanced Search. HT Gene Expression. Meet the Staff. Instrumentation. HT Gene Expression. Instrumentation. Instrumentation. Contact Us Co-Director: Kahraman Tanriverdi, PhD Phone: 508-856-6962 kahraman.tanriverdi@umassmed.edu www.umassmed.edu/htcore. HT Gene Expression. Instrumentation. Instrumentation MagNa Lyser Instrument This instrument simplifies labor-intensive sample preparation. QIAcube Instrument The QIAcube uses QIAGEN spin columns isolation kits, enabling seamless integration of automated, low-throughput sample preparation. JANUS Automated Workstation JANUS Automated Workstation is a liquid handling robot that provides rapid pipetting with superior QC. AB 7900HT Real-Time PCR Instrument In addition to providing fast 96 well, 384 well blocks, the TaqMan Low Density Array TLDA attachment is available for pre-picked gene expression analyses. BioMark Real-Time PCR System The BioMark System provides the a...
http://umassmed.edu/htcore/instrumentation/
*  Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma
... subclasses. What is Broad. Our Approach Areas of Focus History Leadership Who is Broad Partner Institutions Artist-in-Residence Media Center. Press Room News from the Broad Photos for Journalists Spotlight: Ebola Spotlight: CRISPR BroadMinded Blog Video Library For the Scientific Community. Scientific Publications Science Data Software. Scientific Publications Science Data Software. News & Publications:Scientific Publications Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Read More / View Supplemental Materials Somatic mutation in single human neurons tracks developmental and transcriptional history. Read More / View Supplemental Materials Linking RNA biology to lncRNAs. Read More / View Supplemental Materials Ethanol Enhances TGF-β Activity by Recruiting TGF-β Receptors from Intracellular Vesicles/Lipid Rafts/Caveolae to Non-lipid Raft Microdomains. Read More / View Supplemental Materials. Scientific Publications Back to Publications Clas...
https://broadinstitute.org/publications/broad902
*  Browse < ArrayExpress < EMBL-EBI
Browse ArrayExpress EMBL-EBI. Skip to local navigation. Skip to EBI global navigation menu. Skip to expanded EBI global navigation menu includes all sub-sections. Services. Training. Industry. ArrayExpress. Examples: E-MEXP-31, cancer, p53, Geuvadis Advanced. About ArrayExpress. Login. Filter search results By organism: All organisms loading options By experiment type: All assays by molecule loading options. All technologies loading options By array: All arrays loading options. E-GEOD-24551. Exon level expression profiling of colorectal cancer tissue samples. transcription profiling by array. Homo sapiens. - E-GEOD-24550. Exon level expression profiling of colorectal cancer tissue samples validation sample series. transcription profiling by array. Homo sapiens. - E-GEOD-24549. Exon level expression profiling of colorectal cancer tissue samples test sample series. transcription profiling by array. Homo sapiens. - E-GEOD-24030. ChIP-seq, transcription profiling by array. Mus musculus. - E-GEOD-24029. Genome-wid...
http://ebi.ac.uk/arrayexpress/experiments/browse.html?page=1523&pagesize=25
*  Digital Gene-Expression Profiling | GEN Magazine Articles | GEN
Digital Gene-Expression Profiling. Analysis of the RNA-Seq and SCA Publication Landscape. FDA Nominee Driven by "Data, Data, Data". More GEN Exclusives ». Analysis of the RNA-Seq and SCA Publication Landscape. FDA Nominee Driven by "Data, Data, Data". More GEN Exclusives ». Advertorial: OriGene Technologies. Market & Tech An... Jobs. Login/Register. GEN Exclusives More. Analysis of the RNA-Seq and SCA Publication Landscape RNA-Seq and SCA Could Have a... Microarray-based gene-expression profiling technology hardly seems like it has been around long enough for a new approach to come along and challenge its market dominance. Yet, there is a growing sense that digital gene-expression profiling, a fully quantitative approach for gene-expression analysis, will replace microarrays in this application area. Within this emerging market sector for digital RNA counting, the methodologies and technologies are evolving so rapidly that traditional sequencing-based serial analysis of gene-expression approaches are being ch...
http://genengnews.com/gen-articles/digital-gene-expression-profiling/2844/?page=1
*  Use of global gene expression patterns in mechanistic studies of oestrogen action in MCF7 human bre
... ast cancer cells - CentAUR. Use of global gene expression patterns in mechanistic studies of oestrogen action in MCF7 human breast cancer cells. Wordle Link RDF+XML BibTeX RIOXX2 XML RDF+N-Triples JSON Dublin Core Atom Simple Metadata Refer METS HTML Citation with IDs HTML Citation ASCII Citation OpenURL ContextObject EndNote OpenURL ContextObject in Span MODS MPEG-21 DIDL EP3 XML Dublin Core Reference Manager RDF+N3. D 2009 Use of global gene expression patterns in mechanistic studies of oestrogen action in MCF7 human breast cancer cells. Global gene expression profiling has shown that oestrogen action in MCF7 cells involves the coordinated regulation of hundreds of genes across a wide range of functional groupings and that more genes are down regulated than upregulated. Adaptation to long-term oestrogen deprivation, which results in loss of oestrogen-responsive growth, involves alterations to gene patterns not only at early time points 0-4 weeks but continuing through to later times 20-55 weeks, and eve...
http://centaur.reading.ac.uk/9692/
*  BioSpace - A Strategy for Full Interrogation of Prognostic Gene Expression Patterns: Exploring th
... e Biology of Diffuse Large B Cell Lymphoma. Post Jobs. Jobs. A Strategy for Full Interrogation of Prognostic Gene Expression Patterns: Exploring the Biology of Diffuse Large B Cell Lymphoma Published: Thursday, August 04, 2011 Author: Lisa M. LeBlanc Background Gene expression profiling yields quantitative data on gene expression used to create prognostic models that accurately predict patient outcome in diffuse large B cell lymphoma DLBCL. Often, data are analyzed with genes classified by whether they fall above or below the median expression level. We sought to determine whether examining multiple cut-points might be a more powerful technique to investigate the association of gene expression with outcome. Methodology/Principal Findings We explored gene expression profiling data using variable cut-point analysis for 36 genes with reported prognostic value in DLBCL. We plotted two-group survival logrank test statistics against corresponding cut-points of the gene expression levels and smooth estimates of ...
http://biospace.com/PLos_Article.aspx?id=1582
*  DNASTAR - Gene Panel Assembly and Analysis Software | DNASTAR
DNASTAR - Gene Panel Assembly and Analysis Software. DNASTAR. DNASTAR Lasergene. Molecular Biology. Next-Gen Sequencing. Structural Biology. Clinical Research. Molecular Biology. Sanger Sequence Assembly. Sequence Alignment. Structural Biology. Epitope Prediction. Protein Sequence & Structure. Protein Structure Prediction. Structural Alignment. Next-Gen Sequencing. Automated Genome Closure. Cancer Genomics. ChIP-Seq Analysis. De Novo Genome Assembly. De Novo Transcriptome Assembly. Exome Alignment. Gene Panels. Reference Guided Genome Alignment. RNA-Seq Alignment. SNP Validation Control. Variant Analysis. Clinical Research. Cancer Genomics. Gene Panels. SUPPORT. Help. FAQs. Request Support. Supported File Formats. Technical Requirements. Tutorials. NGS Support Materials. #1 in NGS Accuracy. Genome Template Packages. Supported Sequencing Technologies. Genome Assembly. Structure Prediction. Download Free Trial. Request Educational Software. Request Quote. Request Quote. Free Trial. Gene Panel Assembly and Analy...
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*  Multiclass cancer diagnosis using tumor gene expression signatures | Broad Institute of MIT and Harv
Multiclass cancer diagnosis using tumor gene expression signatures. Partnerships Philanthropy Careers Contact Us. Our Approach Areas of Focus History Leadership Who is Broad Partner Institutions Artist-in-Residence Media Center. Press Room News from the Broad Photos for Journalists Spotlight: Ebola Spotlight: CRISPR BroadMinded Blog Video Library For the Scientific Community. Scientific Publications Science Data Software. Scientific Publications Science Data Software. News & Publications:Scientific Publications Multiclass cancer diagnosis using tumor gene expression signatures. Read More / View Supplemental Materials Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores. Read More / View Supplemental Materials. Scientific Publications Back to Publications Multiclass cancer diagnosis using tumor gene expression signatures. To determine whether the diagnosis of multiple common adult malignancies could be achieved purely by molecular classification, we subjected 218 tumor samples, spanning ...
https://broadinstitute.org/publications/broad900
*  PLOS Pathogens: Genome-Wide mRNA Expression Correlates of Viral Control in CD4+ T-Cells from HIV-1-I
... nfected Individuals. Journal Archive. Other Article Types. Article-Level Metrics. Journal Information. View. Sum of PLOS and PubMed Central page views and downloads. Open Access Peer-reviewed Research Article. Genome-Wide mRNA Expression Correlates of Viral Control in CD4+ T-Cells from HIV-1-Infected Individuals. Published: February 26, 2010 DOI: 10.1371/journal.ppat.1000781. Article. 2010 Genome-Wide mRNA Expression Correlates of Viral Control in CD4+ T-Cells from HIV-1-Infected Individuals. doi:10.1371/journal.ppat.1000781 Editor: Michael Emerman, Fred Hutchinson Cancer Research Center, United States of America Received: June 2, 2009; Accepted: January 20, 2010; Published: February 26, 2010 Copyright: © 2010 Rotger et al. Transcriptome analysis in CD4+ T cells from HIV-infected untreated individuals. In total, 260 genes are differentially expressed at adjusted p 0.01 in association with viral load in CD4+ T cells during in vivo HIV-1 infection. Among genes under differential expression during HIV-1 infe...
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1000781
*  A Randomized Phase II Trial Comparing Therapy Based on Tumor Molecular Profiling Versus Conventional
... Therapy in Patients With Refractory Cancer - Full Text View - ClinicalTrials.gov. A Randomized Phase II Trial Comparing Therapy Based on Tumor Molecular Profiling Versus Conventional Therapy in Patients With Refractory Cancer SHIVA This study is currently recruiting participants. If a molecular abnormality is identified for which an approved targeted agent is available, patients are randomized randomized between two arms: Targeted therapy based on the molecular profile Conventional therapy based on investigator's choice. Drug: Targeted therapy based on molecular profiling : Imatinib Procedure: Tumor biopsy Drug: Standard Chemotherapy Drug: Targeted therapy based on molecular profiling : Everolimus Drug: Targeted therapy based on molecular profiling : Vemurafenib Drug: Targeted therapy based on molecular profiling : Sorafenib Drug: Targeted therapy based on molecular profiling : Erlotinib Drug: Targeted therapy based on molecular profiling : Lapatinib + Trastuzumab Drug: Targeted therapy based on molecula...
https://clinicaltrials.gov/ct2/show/NCT01771458
*  Gene expression profiling
... Expression profiling experiments often involve measuring the relative amount of mRNA expressed in two or more experimental conditions. The simplest form of class discovery would be to list all the genes that changed by more than a certain amount between two experimental conditions. Other experiments, such as a Western blot of some of the protein products of differentially expressed genes, make conclusions based on the expression profile more persuasive, since the mRNA levels do not necessarily correlate to the amount of expressed protein. Statistical analysis. Different from the analysis on differentially expressed individual genes, another type of analysis focuses on differential expression or perturbation of pre-defined gene sets and is called gene set analysis. While the statistics may identify which gene products change under experimental conditions, making biological sense of expression profiling rests on knowing which protein each gene product makes and what function this protein performs. Having i...
https://en.wikipedia.org/wiki/Gene_expression_profiling
*  KEGG PATHWAY: Cytokine-cytokine receptor interaction - Canis familiaris (dog)
KEGG PATHWAY: Cytokine-cytokine receptor interaction - Canis familiaris dog. Cytokine-cytokine receptor interaction - Canis familiaris dog. [ Pathway menu Organism menu Pathway entry. Download KGML Show description User data mapping ]. Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped....
http://genome.jp/kegg-bin/show_pathway?cfa04060
*  Gene signature
... a gene signature is a group of gene s in a cell whose combined expression pattern itadani h mizuarai s kotani h can systems biology understand pathway activation gene expression signatures as surrogate markers for understanding the complexity of pathway activation curr genomics aug pmid is uniquely characteristic of a biological phenotype or medical condition liu j campen a huang s peng sb ye x palakal m dunker ak xia y li s identification of a gene signature in cell cycle pathway for breast cancer prognosis using gene expression profiling data bmc med genomics sep pmid the phenotypes that may theoretically be defined by a gene expression signature range from those that are used to differentiate between different subtypes of a disease those that predict the survival or prognosis of an individual with a disease to those that predict activation of a particular pathway ideally gene signatures can be used to select a group of patients wouters bj löwenberg b erpelinck verschueren ca van putten wl valk pj delw...
https://en.wikipedia.org/wiki/Gene_signature
*  Center for Genomics and Public Health - Gene Expression Profiling in Early-Stage Breast Cancer - Gen
... e Expression Profiling in Early-Stage Breast Cancer Risk-Benefit Analysis Case Study. University of Washington Center for Genomics and Public Health. Home Training. Genetic Awareness. Genomic Applications for Public Health Video Series. Policy & Health Economics Videos. Confounding by Population Stratification. Nutrigenomics. Genetic Epidemiology Methods Video Series. Resources. Tools for Public Health Professionals. Publications. Spotlight Factsheets. Links to Other Resources. In the News. Health Topics. DNA Day. Genetics. Genomics versus Genetics. Genetic Testing: what is it. A Public Health Issue. Evidence-Based Review. EGAPP. Glossary. Links to Genetic Testing Resources. Family History & Genomics. BRFSS. BRFSS Timeline. Compilations. Links and Resources. Risk Benefit for Genetics. Risk Benefit Case Studies and Models. About Us. Director's Page. Future of Public Health Genetics. Technical Assistance. Personnel. Contact Us. Partners. The Gene Expression Profiling in Early-Stage Breast Cancer Risk-Benefi...
http://depts.washington.edu/cgph/riskCaseGeneExprBreastCancer
*  .. Boosting Gene Expression Profiling .. !--h2>
Their research program initially focused on using the high-density Affymetrix Human Exon 1.0 ST array platform for monitoring changes in the expression levels of genes and alternative splicing events of hematopoietic cells, both at the gene and exon levels. Her team was interested in looking at the pattern and gene expression modulations in lineage-specific differentiation of CD34+ cells in vitro, noted Dr. Whole transcriptome and exome analysis on both microarrays and sequencing platforms to identify genes that are significantly up- or downregulated during cell differentiation allowed us to discover novel alternatively spliced transcripts, she further explained. Bowcock, Ph.D., professor, applied deep sequencing techniques in identifying major modifications in the changes in mRNA expression profiles of psoriasis patients. In the case of skin differentiation, miRNA gene expression analysis could reveal dramatic changes in global microRNA expression, reflecting defects in keratinocytes, immune cells, and vascu...
http://genengnews.com/keywordsandtools/print/1/29363/
*  Diagnosis of metastatic neoplasms: Molecular approaches for identification of tissue of origin - Res
... earchGate. Article Diagnosis of metastatic neoplasms: Molecular approaches for identification of tissue of origin. Federico Alberto Monzon. Impact Factor: 2.84. Molecular tests for tissue-of-origin determination in metastatic tumors are available and have the potential to significantly impact patient management. Cost-Effectiveness of Gene-Expression Profiling for Tumor-Site Origin. ABSTRACT: Gene-expression profiling GEP reliably supplements traditional clinicopathological information on the tissue of origin TOO in metastatic or poorly differentiated cancer. The average increase in quality-adjusted life-months was 2.7 months 95% CI 1.5-4.3, and average third-party payer costs per patient increased by $10,360 95% CI $2,982-$19,192. DOI:10.1016/j.jval.2012.09.005 3.28 Impact Factor Source Available from: Torik Ayoubi. "Several studies have already demonstrated that it is possible to use genome-wide gene expression analysis using micro-array technology in the determination of the tissue of origin of CUPs Mon...
http://researchgate.net/publication/41397041_Diagnosis_of_metastatic_neoplasms_Molecular_approaches_for_identification_of_tissue_of_origin
*  Gene Ontology Classifications
... Genes. Human Disease. Expression. Genes. Genes Markers Query. Batch Query. Mouse Genome Browser. Human Disease OMIM Browser. Human Disease. Expression. Gene Expression Data Query. Gene Expression Literature Query. Mouse Developmental Anatomy Browser. GO Browser. Genes Markers Query. Batch Query. Sequences. Mouse Genome Browser. Batch Query. Gene Expression Literature Query. GO Browser. Human Disease OMIM Browser. Mouse Developmental Anatomy Browser. Adult Mouse Anatomy Browser. Batch Query. Mouse Genome Browser. Batch Query. Genes Markers. Sequence Data. Gene Ontology Data. Gene Expression. Mouse Resources & Model Organism Links. Phenotypes Mutants Community Resources. Nucleic Acids Research Journal Database Summary. Tabular View GO Graph GO curators for mouse genes have assigned the following annotations to the gene product of Gm2a. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamine...
http://informatics.jax.org/go/marker/MGI:95762
*  statistics - A mathematician's confusion regarding parametric $t$ tests for gene expression data - B
statistics - A mathematician's confusion regarding parametric $t$ tests for gene expression data - Biology Stack Exchange. Biology Meta. more stack exchange communities. Stack Exchange. sign up log in tour. Help Center Detailed answers to any questions you might have. Biology Questions. Sign up. Biology Stack Exchange is a question and answer site for biology researchers, academics, and students. A mathematician's confusion regarding parametric $t$ tests for gene expression data. I'm a mathematician trying to test some things on gene expression data, and I'm thus skimming over various articles such as Sotiriou et. gene-expression statistics share. asked Oct 25 '12 at 15:10. 5 add a comment. 2 Answers 2 active oldest votes. As a computational biologist I would advise you to look specifically at bioinformatics papers if you are looking into developing new methods, since the analysis in "pure biology" papers can often be lacking and would not give you a good perspective of state-of-the-art analysis metho...
http://biology.stackexchange.com/questions/5010/a-mathematicians-confusion-regarding-parametric-t-tests-for-gene-expression-d?answertab=active
*  .. Axela Takes Over Xceed for Ziplex Automated Gene-Expression Analysis Platform
. Send to printer. GEN News Highlights : Jul 26, 2010. Axela Takes Over Xceed for Ziplex Automated Gene-Expression Analysis Platform. Firms claim combined technologies will help speed introduction of new biomarker diagnostics. Axela has acquired Toronto-based Xceed Molecular to get its hands on the latter s Ziplex gene-expression analysis platform and assays. The combined firm will retain the Axela name but move its headquarters to Xceed s facilities in Toronto. Axela says the combination of both companies technologies will provide clinical researchers with a growing suite of products for multiplexing DNA, RNA, and protein biomarker analysis, and help speed the introduction of new diagnostics. Xceed s Ziplex platform has been developed as an integrated and fully automated hybridization system for multiplex gene-expression signatures. The system hinges on Xceed s Flow-Thru Chip FTC technology for multi-analyte analysis, which is embodied in the single-use TipChip consumables that feature self-regulating fluidi...
http://genengnews.com/keywordsandtools/print/4/19944/
*  The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and diseas
... e. Partnerships Philanthropy Careers Contact Us. Our Approach Areas of Focus History Leadership Who is Broad Partner Institutions Artist-in-Residence Media Center. Press Room News from the Broad Photos for Journalists Spotlight: Ebola Spotlight: CRISPR BroadMinded Blog Video Library For the Scientific Community. Scientific Publications Science Data Software. Scientific Publications Science Data Software. News & Publications:Scientific Publications The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Read More / View Supplemental Materials Ethanol Enhances TGF-β Activity by Recruiting TGF-β Receptors from Intracellular Vesicles/Lipid Rafts/Caveolae to Non-lipid Raft Microdomains. Read More / View Supplemental Materials American Diabetes Association and JDRF Research Symposium: Diabetes and the Microbiome. Read More / View Supplemental Materials. Scientific Publications Back to Publications The Connectivity Map: using gene-expression signatures to connect sm...
http://broadinstitute.org/publications/broad3612
*  .. Identifying New Gene-Expression Patterns .. Analyzing Xpress
Identifying New Gene-Expression Patterns. Analyzing XpressWay Human Expression Data with OmniViz Visual Analytics Software. This evaluation is greatly aided by the provision of high-quality gene-expression data and sophisticated software tools for identifying targets with interesting expression patterns. In this article, we describe the combination of Asterand s XpressWay human gene-expression data with BioWisdom s visual analytics software, OmniViz. XpressWay gene-expression data is provided with BioWisdom annotation around gene synonyms, disease, and process information. The inclusion of disease and process information provides context to the gene-expression data, and allows the user to search for interesting targets by virtue of their functional role. Using OmniViz to analyze XpressWay data, it is possible to get an overview of the gene-expression patterns of all ~2,000 genes Figure 1, and then to quickly identify those gene-expression profiles that possess features of interest. For example, if you are int...
http://genengnews.com/keywordsandtools/print/1/12859/
*  BioSpace - Integrated Genomic and Gene Expression Profiling Identifies Two Major Genomic Circuits
... in Urothelial Carcinoma. Post Jobs. Jobs. Career Resources. Career Fairs. Company Profiles. Search Life Sciences Jobs. Integrated Genomic and Gene Expression Profiling Identifies Two Major Genomic Circuits in Urothelial Carcinoma Published: Thursday, June 07, 2012 Author: David Lindgren et al. by David Lindgren, Gottfrid Sjödahl, Martin Lauss, Johan Staaf, Gunilla Chebil, Kristina Lövgren, Sigurdur Gudjonsson, Fredrik Liedberg, Oliver Patschan, Wiking Månsson, Mårten Fernö, Mattias Höglund Similar to other malignancies, urothelial carcinoma UC is characterized by specific recurrent chromosomal aberrations and gene mutations. However, the interconnection between specific genomic alterations, and how patterns of chromosomal alterations adhere to different molecular subgroups of UC, is less clear. We applied tiling resolution array CGH to 146 cases of UC and identified a number of regions harboring recurrent focal genomic amplifications and deletions. Several potential oncogenes were included in the amplifi...
http://biospace.com/PLos_Article.aspx?id=16203
*  This Week in Cancer Research | GenomeWeb
This Week in Cancer Research. GenomeWeb. Skip to main content. RSS Feeds Twitter LinkedIn. Business Policy. Business News Research Funding Policy Legislation Regulatory News Reimbursement. Genetic Research Gene Expression Research Epigenetics Research Proteomics Protein Research Cell Biology Research. Clinical. Molecular Diagnostics Companion Diagnostics Biomarker Discovery Validation Drug Discovery Development Clinical Sequencing Clinical Proteomics. Disease Areas. Cancer Infectious Disease Cardiovascular Disease Neurological Psychological Disease Metabolic Disease Autoimmune Disease Inherited Disease Reproductive Health. Home » This Week in Cancer Research. This Week in Cancer Research Aug 01, 2012. Premium. In Cancer Research this week, a team led by researchers at Laval University in Canada describe the molecular signature found in the lung tissue of smokers. The team carried out genome-wide gene expression profiling on normal lung tissue from 853 lung cancer patients and compared gene expression between ...
https://genomeweb.com/week-cancer-research-20
*  Systems Biology Core Laboratory - New York Medical College
Preparatory techniques: - DNA, RNA and protein extraction, purification, - RNA reverse transcription and fluorescent labeling - DNA and proteins fluorescent labeling - DNA, RNA and protein concentration NanoDrop - DNA, RNA, proteins concentration and QC Bioanalyzer - Western blotting - SpeedVac concentration of proteins, DNAs and RNAs - Controlled PCR amplification B. Hybridization of Agilent microarrays: - Whole Genome Gene Expression microarrays for 30+ species - Exon microarrays human, mouse, rat - miRNA microarrays - CGH Comparative Genomic Hybridization microarrays - CGH+SNP Single Nucleotide Polymorphism microarrays - CNV Copy Number Variant microarrays - ChIP-on-chip Chromatin ImmunoPrecipitation microarrays - DNA methylation CpG islands microarrays C. Hybridization of Illumina beadchips: - Whole Genome Expression BeadChips: human, mouse, rat - Infinium iSelect HD custom genotyping BeadChips for virtually all species - Infinium HumanMethylation450 BeadChip - Infinium HumanCytoSNP-FFPE-12 BeadChips - In...
https://nymc.edu/Research/CoreFacilitiesAndResources/SystemsBiologyCore.html
*  RNAlater® Solution Around the World | FACS Into RNAlater® Solution for Gene Profiling | Thermo Fis
RNAlater® Solution Around the World. FACS Into RNAlater® Solution for Gene Profiling. Thermo Fisher Scientific. Order Support. Custom Products & Projects. Cell Analysis. DNA & RNA Purification. Gene Expression Analysis & Genotyping. PCR. Real-Time PCR. Thermo Scientific. Thermo Scientific. Services. New Products. CaptureSelect™ Products & Services. Diagnostic Products & Services. Thermo Scientific. Air Quality & Water Analysis. Optimized Biopsy Preservation for Clinical Gene Expression and Profiling. Real-Time RT-PCR Directly from Cell Lysates: A Complete Workflow without RNA Purification. Recover High Yields of Total Nucleic Acid from Formalin-fixed, Paraffin-embedded Tissue. RNAlater Preserves Bacterial Gene Expression Profiles for Array Analysis. The Ambion RNA later Tissue Collection: RNA Stabilization Solution is an aqueous tissue storage reagent that stabilizes and protects cellular RNA in intact, unfrozen tissue samples. RNA later Solution eliminates the need to process tissue samples immediately or fr...
https://thermofisher.com/us/en/home/references/ambion-tech-support/rna-isolation/tech-notes/facs-into-rnalater-solution-for-gene-profiling.html
*  Carel A van Baalen - ResearchGate
... For full functionality of ResearchGate it is necessary to enable JavaScript. Here are the instructions how to enable JavaScript in your web browser. Carel A van Baalen. Erasmus MC, Rotterdam, South Holland, Netherlands. Are you Carel A van Baalen. Claim your profile. Publications 36 155.85 Total impact. Article:. DC immunotherapy in HIV-1 infection induces a major blood transcriptome shift. Anna L de Goede. Arno C Andeweg. Henk-Jan van den Ham. Maarten A Bijl. Fatiha Zaaraoui-Boutahar. Wilfred F J van IJcken. Sofie Wilgenhof. Joeri L Aerts. Rob A Gruters. Albert D M E Osterhaus. Sabine D Allard Carel A van Baalen. Brenda De Keersmaecker. Marchina E van der Ende. Kris Thielemans. Patrick Lacor. ABSTRACT: This study aimed to evaluate the effect of dendritic cell DC vaccination against HIV-1 on host gene expression profiles. Longitudinal PBMC samples were collected from participants of the DC-TRN trial for immunotherapy against HIV. Microarray-assisted gene expression profiling was performed to evaluate the...
http://researchgate.net/researcher/38566550_Carel_A_van_Baalen
*  Anti -DAB2, CT (DOC-2, Differentially-expressed Protein 2, Disabled Homolog 2, DOC2) (Biotin) - Unit
Anti -DAB2, CT DOC-2, Differentially-expressed Protein 2, Disabled Homolog 2, DOC2 Biotin - United States Biological. Login. Email. Password. Forgot your password. New User. Remember me. Home. Distributors. Technical. About. Register. Antibodies. Biochemicals. Culture Media. Custom Services. Growth Factors. Bioassay Kits. Lectins. Molecular Biology. Serum, Tissues. Protocols. Newsletter. About Us. Contact. . You are here: Home. Antibodies. Antibodies-Tumor Suppressors. Anti -DAB2, CT DOC-2, Differentially-expressed Protein 2, Disabled Homolog 2, DOC2 Biotin Anti -DAB2, CT DOC-2, Differentially-expressed Protein 2, Disabled Homolog 2, DOC2 Biotin. Pricing For pricing information, USA customers sign in. Outside USA. Please contact your distributor for pricing. Specifications Clone. Host. Grade Applications Polyclonal Rabbit Affinity Purified E B. DAB2 is the component of the CSF-1 signal transduction pathway. Catalog # D0900-19C-Biotin. Applications Suitable for use in ELISA and Western Blot. Other applications...
http://usbio.net/item/D0900-19C-Biotin
*  UTHSC : Office of Research : Molecular Resource Center
... Molecular Resource Center Equipment Bio-Tek FLX 800TBE Microplate Fluorescence Reader DNA Sequencing and Fragment Analysis Fluorescence Microscopy Illumina Microarray BeadStation Universal Probe Library Liquid Handling Robot Microarrays Phosphor-imaging. The reader has an excitation range of 300-650nm and emission range of 340-800nm. The MRC currently has 360nm, 485nm and 508nm excitation filters as well as 460nm, and 528nm emission filters. DNA Sequencing and Fragment Analysis Back to top The MRC currently has an ABI PRISM 310 and two ABI PRISM 3130XL Genetic Analyzers for DNA sequencing and fragment analysis. Illumina Microarray BeadStation Back to top The MRC in collaboration with the Vision Research Core of the Hamilton Eye Institute is pleased to make available an Illumina whole genome SNP and Microarray gene expression analysis core service at UTHSC.Gene expression analysis includes RNA QA/QC, RNA labeling, processing of chip and data analysis.The BeadStation is a complete solution featuring microa...
http://uthsc.edu/research/molecular_resource/Molecular_Resource_Center_Equipment.php
*  PCR Arrays - Pathway Focused Gene Expression Profiling Using Quantitative RT-PCR
... Research Area Complete Array List Browse by Pathway Apoptosis. Browse by Disease Cancer. PCR Arrays are the most reliable tools for analyzing the expression of a focused panel of genes. Each 96-well plate, 384-well plate, or 100-well disc PCR Array includes SYBR Green-optimized primer assays for a thoroughly researched panel of relevant, pathway- or disease-focused genes. New developments in PCR Array technology enable optimal performance of RT Profiler PCR Arrays using RNA prepared from regular samples 0.1 - 5 ug RNA , FFPE samples, and small samples 1 - 100 ng RNA. See the PCR Array Protocol Guide to learn more. Why PCR Arrays. Pathway Focused: Profile the expression of a panel of genes relevant to a pathway or disease state. Simple and Accurate: Simple real-time PCR method provides high sensitivity and wider dynamic range. Specificity: The specificity of the system, imparted by the combination of SYBR Green primers and PCR master mixes, guarantees a single product of the predicted size from every reac...
http://sabiosciences.com/PCRArrayPlate.php
*  TaqMan® Probe-Based Gene Expression Analysis
... by Life Technologies. Applications Technologies. All Categories Search. Contact Information. TaqMan Assays. DNA / RNA Purification. Gene Expression. PCR. Real-Time PCR. siRNA, miRNA Non-Coding RNA. Custom TaqMan Array. TaqMan Gene Expression Assays. TaqMan MicroRNA Assays. TaqMan SNP Genotyping Assays. TaqMan Protein Assays. Applications Technologies. Home > Applications & Technologies > qPCR Real-Time PCR > TaqMan® Probe-Based Gene Expression Analysis. TaqMan® Probe-Based Gene Expression Analysis. RNA from samples of interest is reverse transcribed into cDNA, and the synthesized cDNA serves as the template for real-time PCR. Which TaqMan Gene Expression Assay or Array is right for you. 96-Well Plates Easy-to-use 96-well plates are compatible with our 7500 Fast, 7900HT, ViiA 7 and StepOnePlus Real-Time PCR Systems. 384-Well Plates 384-well plates can be configured with any TaqMan Gene Expression Assays, including custom assays designed to your target sequences. 384-Well Microfluidic Cards 384-well cards ...
http://appliedbiosystems.com/absite/us/en/home/applications-technologies/real-time-pcr/taqman-probe-based-gene-expression-analysis.html
*  T Ideker
Research Topics galactose fungal gene expression regulation galactosephosphates human genome project fungal rna fungal genome monosaccharide transport proteins yeasts oligonucleotide array sequence analysis genetic databases likelihood functions gene expression profiling proteome fungal proteins factual databases computational biology saccharomyces cerevisiae proteins culture media saccharomyces cerevisiae genetic models computer assisted image processing expressed sequence tags complementary dna molecular probe techniques prostate. Publications Integrated genomic and proteomic analyses of a systematically perturbed metabolic network T Ideker The Institute for Systems Biology, 4225 Roosevelt Way NE, Suite 200, Seattle, WA 98105, USA Science 292:929-34. 2001 Testing for differentially-expressed genes by maximum-likelihood analysis of microarray data T Ideker Department of Molecular Biotechnology, University of Washington, Seattle, WA 98195, USA J Comput Biol 7:805-17. 2001 Negative selection: a method for obta...
http://labome.org/expert/usa/institute/ideker/t-ideker-622821.html
*  GEO Profile Links for PubMed (Select 15961561) - GEO Profiles - NCBI
GEO Profile Links for PubMed Select 15961561 - GEO Profiles - NCBI. NCBI. BLAST Basic Local Alignment Search Tool. BLAST Basic Local Alignment Search Tool. DataSet type: Expression profiling by array, transformed count, 12 samples ID: 106850905 GEO DataSets Gene UniGene Profile neighbors Chromosome neighbors. DataSet type: Expression profiling by array, transformed count, 12 samples ID: 106850904 GEO DataSets Gene UniGene Profile neighbors Chromosome neighbors. DataSet type: Expression profiling by array, transformed count, 16 samples ID: 92080805 GEO DataSets Gene UniGene Profile neighbors Chromosome neighbors. DataSet type: Expression profiling by array, transformed count, 16 samples ID: 92080804 GEO DataSets Gene UniGene Profile neighbors Chromosome neighbors. DataSet type: Expression profiling by array, count, 40 samples ID: 91918105 GEO DataSets Gene UniGene Profile neighbors Chromosome neighbors. DataSet type: Expression profiling by array, count, 40 samples ID: 91918104 GEO DataSets Gene UniGene Profil...
http://ncbi.nlm.nih.gov/geoprofiles?LinkName=pubmed_geoprofiles&from_uid=15961561
*  Gene Ontology Classifications
Genes. Genes. Genes Markers Query. Batch Query. Mouse Genome Browser. Human Disease OMIM Browser. Gene Expression Data Query. Gene Expression Literature Query. GO Browser. Genes Markers Query. Batch Query. Mouse Genome Browser. Batch Query. Gene Expression Literature Query. GO Browser. Human Disease OMIM Browser. Batch Query. Mouse Genome Browser. Batch Query. Genes Markers. Sequence Data. Gene Ontology Data. Gene Expression. Nucleic Acids Research Journal Database Summary. Tabular View GO Graph GO curators for mouse genes have assigned the following annotations to the gene product of Stx16. Summary from NCBI RefSeq This gene encodes a protein that is a member of the syntaxin or t-SNARE target-SNAP receptor family. These proteins are found on cell membranes and serve as the targets for V-SNARES vesicle-SNAP receptors permitting specific synaptic vesicle docking and fusion. Summary text based on GO annotations supported by experimental evidence in mouse Researchers have inferred from direct assay, that the gen...
http://informatics.jax.org/go/marker/MGI:1923396
*  Gene Ontology Classifications
Genes. Expression. Genes. Genes Markers Query. Batch Query. Mouse Genome Browser. Human Disease OMIM Browser. Expression. Gene Expression Data Query. Gene Expression Literature Query. GO Browser. Genes Markers Query. Batch Query. Mouse Genome Browser. Batch Query. Gene Expression Literature Query. GO Browser. Human Disease OMIM Browser. Mouse Developmental Anatomy Browser. Batch Query. Mouse Genome Browser. Batch Query. Genes Markers. Sequence Data. Gene Ontology Data. Gene Expression. Nucleic Acids Research Journal Database Summary. Symbol Name ID Kcns2 K+ voltage-gated channel, subfamily S, 2 MGI:1197011. Tabular View GO Graph GO curators for mouse genes have assigned the following annotations to the gene product of Kcns2. Summary text based on GO annotations supported by experimental evidence in other organisms From comparative sequence analysis see table for details, MGI curators have determined that the gene product of Kcns2 : participates in the following biological processes: potassium ion transmembran...
http://informatics.jax.org/go/marker/MGI:1197011
*  Gene Ontology Classifications
Genes Markers Query. Batch Query. Mouse Genome Browser. Gene Expression Data Query. Genes Markers Query. Batch Query. Mouse Genome Browser. Batch Query. Batch Query. Mouse Genome Browser. Batch Query. Genes Markers. Sequence Data. Gene Ontology Data. Phenotypes Mutants Community Resources. Symbol Name ID Cacna2d2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 MGI:1929813. Tabular View GO Graph GO curators for mouse genes have assigned the following annotations to the gene product of Cacna2d2. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. Summary text based on GO annotations supported by experimental evidence in mouse Researchers have inferred from direct assay, that the gene product of Cacna2d2 performs the following molecular functions: voltage-gated calcium channel activity. is located in the following cellular components: voltage-gated calcium channel complex. Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene...
http://informatics.jax.org/go/marker/MGI:1929813
*  DNA Microarrays for KGD1 and YIL127C
If a non-annotated gene's are expression pattern is similar to an annotated gene, then may share a common function, promoter or transcription factor. Figure 1: TCA cycle for yeast. MICROARRAY DATA FOR KGD1 Eleven different experiments are listed in the Expression Connection database: Expression response to different alpha factor concentrations 1 Expression response to alpha factor 2 Expression response to DNA damaging agents 3 Expression response to diauxic shift 4 Expression response to glucose limitation 5 Expression regulated by PHO pathway 6 Expression response to environmental changes 7 Expression response during the cell cycle 8 Expression response to histone depletion 9 Expression response to sporulation 10 Expression response to varying zinc levels 11. Figure 5: Scale for gene induction and repression for all DNA microarray experiments. Figure 6: Gene expression for KGD1 at various alpha factor concentrations. This suggests that enzymes in a metabolic pathway have similar expression profiles. Figure 7...
http://bio.davidson.edu/courses/genomics/2002/Cubre/project3.html
*  Patent US7026121 - Methods and compositions for diagnosing and monitoring transplant rejection - Goo
While blood provides a very attractive substrate for the study of diseases using expression profiling techniques, and for the development of diagnostic technologies and the identification of therapeutic targets, the value of expression profiling in blood samples rests on the degree to which changes in gene expression in these cell types are associated with a predisposition to, and pathogenesis and progression of a disease. A Example of rejection and no-rejection samples expression data for 5 marker genes. This table contains 4517 identified cDNAs and cDNA regions of genes that are members of a leukocyte candidate library, for use in measuring the expression of nucleotide sequences that could subsequently be correlated with human clinical conditions. For each of the CMV gene expression markers identified in Table 11A, 2 sets of PCR primer pairs are shown that were derived by the methods described in example 25. For each of the rejection gene expression markers identified in Table 12A, 2 sets of PCR primer pair...
http://google.com/patents/US7026121?dq=6,712,702
*  Gene Ontology Classifications
Genes. Genes. Genes Markers Query. Batch Query. Mouse Genome Browser. Gene Expression Data Query. Genes Markers Query. Batch Query. Mouse Genome Browser. Batch Query. Batch Query. Mouse Genome Browser. Batch Query. Genes Markers. Sequence Data. Gene Ontology Data. Gene Expression. Mouse Resources & Model Organism Links. Tabular View GO Graph GO curators for mouse genes have assigned the following annotations to the gene product of Sh2d1a. Summary text based on GO annotations supported by experimental evidence in mouse The gene product of Sh2d1a has been shown to bind to the gene products of Slamf1. Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Sh2d1a participates in the following biological processes: humoral immune response. Researchers have inferred, based on genetic interactions, that the gene product of Sh2d1a participates in the following biological processes: positive regulation of natural killer cell mediated cytotoxicity based on interactions with S...
http://informatics.jax.org/go/marker/MGI:1328352
*  Gene Ontology Classifications
Genes. Genes. Genes Markers Query. Batch Query. Mouse Genome Browser. Gene Expression Data Query. Genes Markers Query. Batch Query. Mouse Genome Browser. Batch Query. Batch Query. Mouse Genome Browser. Batch Query. Genes Markers. Sequence Data. Gene Ontology Data. Tabular View GO Graph GO curators for mouse genes have assigned the following annotations to the gene product of Trf. Summary text based on GO annotations supported by experimental evidence in mouse Researchers have inferred from direct assay, that the gene product of Trf participates in the following biological processes: actin filament organization. Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Trf participates in the following biological processes: iron ion transport. Summary text based on GO annotations supported by experimental evidence in other organisms From comparative sequence analysis see table for details, MGI curators have determined that the gene product of Trf : participates in the f...
http://informatics.jax.org/go/marker/MGI:98821
*  Gene Ontology Classifications
Genes Markers Query. Mouse Genome Browser. Gene Expression Data Query. Genes Markers Query. Mouse Genome Browser. Mouse Genome Browser. Genes Markers. Sequence Data. Gene Ontology Data. Summary text based on GO annotations supported by experimental evidence in mouse Researchers have inferred from direct assay, that the gene product of Stxbp1 participates in the following biological processes: negative regulation of synaptic transmission, GABAergic. Researchers have inferred, based on physical interactions, that the gene product of Stxbp1 performs the following molecular functions: syntaxin-1 binding. Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Stxbp1 participates in the following biological processes: axon target recognition. Summary text based on GO annotations supported by experimental evidence in other organisms From comparative sequence analysis see table for details, MGI curators have determined that the gene product of Stxbp1 : participates in the f...
http://informatics.jax.org/go/marker/MGI:107363
*  Smokers undergo the same changes in gene expression as patients with COPD
... Home. Diseases, Conditions, Syndromes. May 9, 2011 Smokers undergo the same changes in gene expression as patients with COPD May 9, 2011. Smokers undergo the same changes in gene expression as patients with COPD. Credit: SINC 'Healthy' smokers experience changes in the gene expression of their lungs similar to that suffered by smokers who have developed Chronic Obstructive Pulmonary Disease COPD. This is the conclusion of a new study, led by Catalan researchers, which confirms the crucial role that smoking plays in causing these alterations. "Our objective was to analyse the expression of a range of genes in the pulmonary tissue samples of patients with COPD, whether smokers or not, and people who had undergone operations for cancer or lung transplants", Ricardo Bastos, lead author of the study and a researcher at the August Pi i Sunyer Biomedical Research Institute IDIBAPS, tells SINC. Using the real-time polymerase chain reaction PCR technique, the scientists analysed the expression of 42 genes related...
http://medicalxpress.com/news/2011-05-smokers-gene-patients-copd.html
*  Digital Gene-Expression Profiling | GEN Magazine Articles | GEN
Transitioning from Traditional Assay Formats to HTRF Technology. Transitioning from Traditional Assay Formats to HTRF Technology. Market & Tech Analysis. Page 3 of 5 Single Molecule Sequencing Patrice Milos, Ph.D., vp and CSO at Helicos Biosciences, described the company s genetic analysis system at Cambridge Healthtech s Next Generation Sequencing conference in San Diego last month in a presentation entitled, Enabling True Biology with Helicos Single Molecule Sequencing. DNA sample preparation on the HeliScope Single Molecule Sequencer requires no ligation steps or PCR amplification, Dr. The basic process for quantitative RNA analysis involves creating a single-stranded copy of the total or poly A+ RNA sample using reverse transcriptase, adding a polyA tail to the cDNA, and allowing these to hybridize to a flow cell surface containing oligo dT to initiate sequencing by synthesis reactions of the single-copy transcript tags. The 50-channel HeliScope can generate 12 to 14 million reads in a single channel, wit...
http://genengnews.com/gen-articles/digital-gene-expression-profiling/2844/?page=3
*  Basal Cell Carcinoma, Multiple disease: Malacards - Research Articles, Symptoms, Drugs, Genes, C
Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatom...
http://malacards.org/card/basal_cell_carcinoma_multiple
*  Fgfr2-Related Craniosynostosis disease: Malacards - Research Articles, Symptoms, Drugs, Genes, C
Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatom...
http://malacards.org/card/fgfr2_related_craniosynostosis
*  Orbit Rhabdomyosarcoma disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical
Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatom...
http://malacards.org/card/orbit_rhabdomyosarcoma
*  Branchiootorenal Spectrum Disorders disease: Malacards - Research Articles, Symptoms, Drugs, Gen
Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatom...
http://malacards.org/card/branchiootorenal_spectrum_disorders
*  Swine Influenza disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials
Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatom...
http://malacards.org/card/swine_influenza
*  Deafness, Autosomal Dominant 3b disease: Malacards - Research Articles, Symptoms, Drugs, Genes,
Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatom...
http://malacards.org/card/deafness_autosomal_dominant_3b
*  Umod-Associated Kidney Disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical
Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatom...
http://malacards.org/card/umod_associated_kidney_disease
*  Large-Related Muscle Diseases: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical T
Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatom...
http://malacards.org/card/large_related_muscle_diseases
*  Venous Tributary Occlusion of Retina disease: Malacards - Research Articles, Symptoms, Drugs, Ge
Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatom...
http://malacards.org/card/venous_tributary_occlusion_of_retina
*  Dfna 8/12 Nonsyndromic Hearing Loss and Deafness disease: Malacards - Research Articles, Symptom
Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatom...
http://malacards.org/card/dfna_8_12_nonsyndromic_hearing_loss_and_deafness
*  Brachyolmia disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials
Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatom...
http://malacards.org/card/brachyolmia
*  Scotoma disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials
Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatom...
http://malacards.org/card/scotoma
*  Non-Classic Cystic Fibrosis-Like Syndrome disease: Malacards - Research Articles, Symptoms, Drug
Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatom...
http://malacards.org/card/non_classic_cystic_fibrosis_like_syndrome
*  Myopathy, Distal, Tateyama Type disease: Malacards - Research Articles, Symptoms, Drugs, Genes,
Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatom...
http://malacards.org/card/myopathy_distal_tateyama_type
*  Splenic Sequestration disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical T
Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatom...
http://malacards.org/card/splenic_sequestration
*  Progeroid Laminopathies disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical
Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatom...
http://malacards.org/card/progeroid_laminopathies
*  Differential gene expression triggered by highly cytotoxic α-Emitter-immunoconjugates in gastric ca
... ncer cells - Springer. Affiliated with Department of Nuclear Medicine, Technische Universität München. Affiliated with Department of Nuclear Medicine, Technische Universität München. Affiliated with Department of Nuclear Medicine, Technische Universität München. Share Share this content on Facebook Share this content on Twitter Share this content on LinkedIn. CrossRef. PubMed. CrossRef. PubMed. PubMed. CrossRef. CrossRef. PubMed. Cancer Res 66:8227–8232 doi: 10.​1158/​0008-5472.​CAN-06-1189. CrossRef. PubMed. PubMed. Huber R, Seidl C, Schmid E, Seidenschwang S, Becker KF, Schuhmacher C, Apostolidis C, Nikula T, Kremmer E, Schwaiger M, Senekowitsch-Schmidtke R 2003 Locoregional α-radioimmunotherapy of intraperitoneal tumor cell dissemination using a tumor specific monoclonal antibody. Seidl C, Schröck H, Seidenschwang S, Beck R, Schmid E, Abend M, Becker KF, Apostolidis C, Nikula TK, Kremmer E, Schwaiger M, Senekowitsch-Schmidtke R 2005 Cell death triggered by alpha-emitting 213 Bi-immunoconjugates in HSC4...
http://link.springer.com/article/10.1007/s10637-008-9214-4
*  Gene Expression - DnaTube.com - Scientific Video and Animation Site
... DNATUBE. . Sign In. Sign In. Sign In. Remember me. Forgot password. Connect With Facebook. Manual create account. Videos. Lectures. Upload. share on twitter. share this page with the world. 12900 views. Gene Expression Gene Expression which information from a gene is used in the synthesis of a functional gene product is shown in this video. more... Gene Expression which information from a gene is used in the synthesis of a functional gene product is shown in this video. less... Comments. Embed. Download. Features. You need to login to download this video. or login or signup. Channels:. Genetics Tags:. geneexpression Upload by:. shiva on 03-10-2007. Duration: 6m 8s. Watch VIDEO. 28263 views. Mechanism of gene expression 02:02. Watch VIDEO. 1811 views. Microarray Gene expression 01:22. Watch VIDEO. 2001 views. Lec 18 - Biology 1A -Gene Expression I - ... Watch VIDEO. 1873 views. Lec 19 - Biology 1A - Gene Expression II ... 53:21. Watch VIDEO. 1902 views. Lec 20 - Biology 1A - Regulation of Gene ... 55:06. ...
http://dnatube.com/video/1064/Gene-Expression
*  Exploiting Gene-Expression Data | GEN Magazine Articles | GEN
Market & Tech Analysis. In a recent study in Respiratory Research entitled Systems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitro, a research team from China and Canada utilized gene-expression analysis to compare transcriptional responses to infection with a seasonal H1N1 influenza virus or a pandemic H1N1 influenza virus isolated during the 2009 influenza pandemic. Using iReport, the Ingenuity Systems researchers not only validated the published results, they also identified additional genes, pathways, and processes involved in seasonal H1N1 influenza compared to pandemic influenza infection from the same data, said Megan Laurance, Ph.D., product manager at Ingenuity Systems. The study reportedly also demonstrated a 50% increase in the detection of genes and a 500% increase in isoform detection. At 25 million sequencing reads, the numbers jumped to 40 50% increase in the magnitude of genes found to ...
http://genengnews.com/gen-articles/exploiting-gene-expression-data/4046/?page=2
*  The Cheng Lab - Research
. The Cheng Lab - Research. The interest of our lab is genetics, genomic and human disease. We focus on developing computational methods to better understand transcriptional regulation underlying biological processes and human diseases. To facilitate method development, we choose three levels of models- cell cycle regulation for pathway level, stem cell for cell level, and breast cancer for disease level. More specifically, our research interests include:. 1 Construct integrated regulatory network underlying cancer and other diseases Biological processes are precisely regulated by TFs, miRNAs and other regulators. We aim to combine data from different sources, e.g, TF binding data ChIP-seq and ChIP-chip, gene expression data microarray and RNA-seq, with computational techniques to construct the integrated regulatory networks underlying cancer and other diseases. 2 Infer combinatorial interactions among TFs under different conditions TFs are collaborated with each other during transcriptional regulation. We ai...
http://dartmouth.edu/~chaocheng/index.html
*  User:Pranav Rathi/Notebook/OT/2010/04/13/Mode profiling at high power - OpenWetWare
... User:Pranav Rathi/Notebook/OT/2010/04/13/Mode profiling at high power From OpenWetWare User:Pranav Rathi. Notebook. 13 Revision as of 17:34, 15 November 2012 by Pranav Rathi Talk. Current revision diff. Newer revision→ diff. 1 Power Step-Up Beam Profile experiment BPE 1.1 Experiment: Beam profile Vs laser power 1.1.1 Introduction 1.1.2 Motivation 1.1.3 Set-Up 1.1.4 Procedure 1.1.5 Results 1.1.6 Conclusion. 1.2 Experiment: Beam profile Vs laser temperature. Power Step-Up Beam Profile experiment BPE. Experiment: Beam profile Vs laser power. Correct beam profile is very important for optical trap; in our case its 0, 0 Gaussian mode. The motivation behind doing this experiment is to answer some questions. Answer the following questions. At what output power the beam profile starts changing. The profiling is done from .2W to 4.1W in .3W steps at 85 deg F, laser temperature. The beam was passed through AOM AOM at CW mode and 2nd order diffracted beam was picked for profiling. The profiling is done through a re...
http://openwetware.org/index.php?title=User:Pranav_Rathi/Notebook/OT/2010/04/13/Mode_profiling_at_high_power&oldid=656794
*  Articles Added on November 15, 2012
In the present study, we observed that the cells from p110 -/- mice gain ... Near patient anti-platelet response testing over time and gene analysis in patients ... The role of platelet activation in determining response to therapy in patients ... Deficits in emotion perception are thought to underlie this clinical feature, although studies examining emotion recognition abilities in BPD have yielded inconsistent findings. Method The results of 10 studies contrasting facial emotion recognition in patients with BPD n = 266 ... We aimed to investigate the effects of valsartan and amlodipine on the PTX3 and C-reactive protein CRP levels in patients with essential hypertension. Time-dependent network analysis reveals molecular targets underlying the development of diet-induced obesity ... We combine molecular networks and time course gene expression profiles to reveal the dynamic changes in molecular networks underlying diet-induced obesity and NASH. Controversy reigns as to how protein binding changes alter the t...
http://biomedsearch.com/added/20121115-p14.html
*  Obstructive Lung Disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials
Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. AHSP antibody SFTPC antibody AGER antibody LTA antibody RNASE3 antibody REN antibody. 4 pulmonary disease, chronic obstructive 30.3 RNASE3, AHSP. 6 atopy 29.9 RNASE3, LTA. 7 rheumatoid arthritis 29.6 RNASE3, AGER, LTA. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Model...
http://malacards.org/card/obstructive_lung_disease
*  Parkinson Disease, Late-Onset: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical T
Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. TBP antibody MAPT antibody ADH1C antibody GBA antibody GLUD2 antibody DNAJC13 antibody MT-ND1 antibody MC1R antibody PARK2 antibody VPS35 antibody. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Term...
http://malacards.org/card/parkinson_disease_late_onset
*  Marshall Syndrome disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trial
Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. 6 COL11A1 NM 080629.2 COL11A1 : c.3852+1G> A single nucleotide variant Pathogenic rs398122828 GRCh37 Chr 1, 103381186: 103381186. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Product...
http://malacards.org/card/marshall_syndrome
*  Eagle-Barrett Syndrome disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical
Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. id Description Frequency HPO Source Accession 1 cryptorchidism hallmark 90% HP:0000028. 5 aplasia/hypoplasia of the abdominal wall musculature hallmark 90% HP:0010318. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes G...
http://malacards.org/card/eagle_barrett_syndrome
*  Browsing HMS Scholarly Articles by Author "63112ea8ba2b9169868fda4abeec19e1"
browsing hms scholarly articles by author ea ba b fda abeec e browsing hms scholarly articles by author ea ba b fda abeec e dspace manakin repository dash home harvard medical school hms scholarly articles browsing hms scholarly articles by author login browsing hms scholarly articles by author ea ba b fda abeec e a b c d e f g h i j k l m n o p q r s t u v w x y z or enter first few letters sort by submit date title issue date order ascending descending results now showing items of aberrant expression of functional baff system receptors by malignant b cell precursors impacts leukemia cell survival maia sara pelletier marc ding jixin hsu yen ming rao sambasiva p cardoso angelo a sallan stephen earl et al plos one link to published version ex vivo expansion of human cd t cells using autologous cd t cell help butler marcus o imataki osamu yamashita yoshihiro tanaka makito ansén sascha berezovskaya alla metzler genita et al plos one link to published version high throughput gene expression profiling of memory di...
http://dash.harvard.edu/handle/1/4454686/browse?authority=63112ea8ba2b9169868fda4abeec19e1&type=author
*  Personal genetic profiling services lack evidence for claims
... Home. Medicine Health. Genetics. October 12, 2010 Personal genetic profiling services lack evidence for claims October 12, 2010 Direct-to-consumer personal genetic profiling services that claim to predict people's health risks by analysing their DNA are often inconclusive and companies that sell them should provide better information about the evidence on which the results are based, says the UK Nuffield Council on Bioethics, in a new report on the ethics of so-called personalised healthcare services. The report says that claims that these services are leading to a new era of 'personalised healthcare' are overstated and should be treated with caution. The Council recommends that regulators of these services and advertising regulators should request evidence to back up the claims made by companies. The services are marketed to healthy people as a way of finding out their risk of developing serious conditions such as diabetes, heart disease, Parkinson's disease and some cancers. But people taking the tests...
http://phys.org/news/2010-10-personal-genetic-profiling-lack-evidence.html
*  GEN News Highlights Related To | GEN
Transitioning from Traditional Assay Formats to HTRF Technology. Wound Care Pipelines Expand with Bioactive Market. Jobs Report: Data, Business, and Regulatory Savvy Driving New Hiring. Transitioning from Traditional Assay Formats to HTRF Technology. Wound Care Pipelines Expand with Bioactive Market. Jobs Report: Data, Business, and Regulatory Savvy Driving New Hiring. Market & Tech Analysis. GEN News Highlights Related to Comparative Genomics: Insights into Disease Susceptibility Engineered Mosquitoes Resist Malaria Infection Third Rock, Sanofi Launch Drug Discovery Firm, Warp Drive, with $125M CIRM to Put $40M into Stem Cell Genomic Centers Exosome, LMU Awarded €1M to Develop Blood-Based Exosome Diagnostics for Cancer Affymetrix to Distribute Almac’s Expression-Profiling Array for FFPE Samples Ingenuity, Life Tech Introduce Solution for Real-Time PCR Gene-Expression Analysis Plexpress to Raise up to $2.3M to Commercialize Multiplex Gene-Expression Analysis Platform Fusion Protein Effectively Delivers Antica...
http://genengnews.com/more/related/gen-news-highlights/4/31143/?page=22
*  MOPED
Absolute Expression Chart. Data Set: proteomics pathways Organism:. Relative Expression Chart. Experiments: A - G H - N O - T U - Z. Absolute Expression Chart. Protein Absolute Expression Click here to view Protein Absolute Expression. Tissue/Cell Type. Enter keyword or prefix, wildcard * is supported, search is case-insensitive: HSPD1 hspa *spd* Enter multiple terms separated by spaces to find records that match any of the terms OR search : P69905 P11404 hspa *spd* Search can be restricted to specific fields protein, description, organism, chromosome, gene, condition, localization, tissue, experiment : tissue=lung gene=hsp* Use logical expressions for more complex searches: gene=hspa5 and tissue=liver or tissue=breast. Highlights Absolute Expression: compare protein concentrations within and across experiments. Experiment Description Journal References Tissue/Cell Type : Localization : Condition Moghaddas CellReports 2013 proteomes Global proteome analysis of the NCI-60 cell line panel Moghaddas et. RESULTS:...
https://proteinspire.org/MOPED/mopedviews/proteinExpressionDatabase.jsf?organismId=Human&proteinId=P78424
*  Browsing ENG: Bioinformatics: Scholarly Papers by Title
... OpenBU. Browsing ENG: Bioinformatics: Scholarly Papers by Title. OpenBU. Login. Help. OpenBU. →. College of Engineering. →. Bioinformatics. →. ENG: Bioinformatics: Scholarly Papers. → Browsing ENG: Bioinformatics: Scholarly Papers by Title. JavaScript is disabled for your browser. Some features of this site may not work without it. Browsing ENG: Bioinformatics: Scholarly Papers by Title. 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S. T. U. V. W. X. Y. Z. Or enter first few letters:. Sort by: title issue date submit date Order: ascending descending Results: 5 10 20 40 60 80 100. Now showing items 41-60 of 100. Previous Page. Next Page. High-Precision High-Coverage Functional Inference from Integrated Data Sources . Linghu, Bolan ; Snitkin, Evan S ; Holloway, Dustin T ; Gustafson, Adam M ; Xia, Yu ; DeLisi, Charles BioMed Central, 2008-2-25. BACKGROUND. Information obtained from diverse data sources can be combined in a principled manner using various machine learning methods to increase th...
http://open.bu.edu/handle/2144/2434/browse?order=ASC&rpp=20&sort_by=1&etal=-1&offset=40&type=title
*  Gene Ontology Classifications
Genes Markers Query. Genes Markers Query. Sequence Data. Summary text based on GO annotations supported by experimental evidence in mouse Researchers have inferred from direct assay, that the gene product of Nr5a1 participates in the following biological processes: maintenance of protein location in nucleus. Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Nr5a1 participates in the following biological processes: adrenal gland development. Researchers have inferred, based on genetic interactions, that the gene product of Nr5a1 participates in the following biological processes: adrenal gland development based on interactions with Nr0b1. Summary text based on GO annotations supported by experimental evidence in other organisms From comparative sequence analysis see table for details, MGI curators have determined that the gene product of Nr5a1 : participates in the following biological processes: positive regulation of male gonad development. RNA polymerase II d...
http://informatics.jax.org/go/marker/MGI:1346833
*  Gene Ontology Classifications
Summary from NCBI RefSeq The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Summary text based on GO annotations supported by experimental evidence in mouse Researchers have inferred from direct assay, that the gene product of Cav1 participates in the following biological processes: negative regulation of canonical Wnt signaling pathway. performs the following molecular functions: protein binding, bridging. Researchers have inferred, based on physical interactions, that the gene product of Cav1 performs the following molecular functions: nitric-oxide synthase binding. Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Cav1 participates in the following biological processes: calcium ion homeostasis. regulation of cell communication by electrical coupling involved in ca...
http://informatics.jax.org/go/marker/MGI:102709
*  OnPoint Custom Labeling Services | PerkinElmer
OnPoint Custom Labeling Services. PerkinElmer. Customer Care :800-762-4000. Tools Cocktails, Vials, Microplates. Certificate of Analysis. COMPETITOR CROSS REFERENCE Analytical Science Products. Life Science Products. Reagents. Products. Assays Reagents. Assays That Deliver Results. Alpha Technology. Blotting Reagents. Cell Lines, Frozen Cells & Membranes. Clinical Diagnostics Reagents. Clinical MSMS Reagents. Cytogenetic Diagnostic Products. Cytogenetic Research Only Products. In Vivo Imaging Reagents. LANCE Assays. Lites Luminescence Assays. Maternal Fetal Health Reagents. Newborn Screening Reagents. Radioimaging & Radiotherapeutics. Receptor Ligand Binding Assays. Atomic Spectroscopy. Biological Sample Collection. Chromatography Systems. Elemental Analysis. Food Test Kits. Labeling & Detection. Liquid Handling. Live Cell Imaging. Mass Spectrometers. Microplates. Molecular Spectrometers. Newborn Screening Systems. Preclinical In Vivo Imaging Accessories. Prenatal Screening Systems. Sample Preparation. Scinti...
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*  KEGG T01001: 3596
... Homo sapiens human : 3596. Entry 3596 CDS T01001. Gene name IL13, IL-13, P600. Definition RefSeq interleukin 13. KO K05435. interleukin 13. Organism hsa Homo sapiens human. Pathway hsa04060. Cytokine-cytokine receptor interaction. hsa04630. Jak-STAT signaling pathway. hsa04664. Fc epsilon RI signaling pathway. hsa05162. Measles. hsa05310. Asthma. hsa05321. Inflammatory bowel disease IBD. Disease H00079. Asthma. H00084. Graft-versus-host disease. H01358. Atopic dermatitis. H01360. Allergic rhinitis. Drug target Other: D08857 D09633 D09979 D10438. Brite KEGG Orthology KO Environmental Information Processing Signal transduction 04630 Jak-STAT signaling pathway 3596 IL13 Signaling molecules and interaction 04060 Cytokine-cytokine receptor interaction 3596 IL13 Organismal Systems Immune system 04664 Fc epsilon RI signaling pathway 3596 IL13 Human Diseases Immune diseases 05310 Asthma 3596 IL13 05321 Inflammatiory bowel disease IBD 3596 IL13 Infectious diseases 05162 Measles 3596 IL13 Cytokines Class I cytokin...
http://kegg.jp/dbget-bin/www_bget?hsa:3596
*  www.genomebiology.com - Figure 1
www genomebiology com figure resolution standard high figure microarray analysis of differential gene expression in wild type and knockout fibroblasts h ras n ras and h ras n ras subjected to serum starvation or stimulation graphical representation of numbers of probesets showing differential gene expression in pair wise sam comparisons between the microarray hybridization data of wt fibroblasts that were serum starved for hours control and corresponding microarray hybridization data of fibroblasts of the indicated wt and ras knockout genotypes obtained before h or after short term h or mid term h post starvation incubation of the cultures in the presence of fetal bovine serum fbs four independent microarray hybridizations were performed for all conditions involving wt samples and at least three independent hybridizations were performed with rna of each of the different knockout genotypes analyzed numbers shown indicate the amount of induced red or repressed green differentially expressed probesets that were ...
http://genomebiology.com/2009/10/11/R123/figure/F1
*  Technology Networks - The Online Scientific Community - Events
... Technology Networks. Scientific Communities. qPCR. Events - November 2013. 3 days Experimental design and data analysis 06 Nov 2013 - 08 Nov 2013 - TATAA Biocenter, Prague. 3 DAYS EXPERIMENTAL DESIGN AND STATISTICAL DATA ANALYSIS FOR QPCR Target audience : Medium to Advanced qPCR users Entrance qualifications : Hands-on qPCR module or similar knowledge Description : This is a comprehensive course teaching the basics of statistics including the most common methods to analyze univariate as well as multivariate qPCR. The course contains: Day 1- Real-time PCR experimental design and basic data processing Basic principles of statistics Experimental design, selecting reference genes Absolute quantification Day 2- Statistical analysis of real-time PCR data Advanced principles of statistics Statistical tests Ability to detect a difference Separate variance contributions Relative quantification, Comparison of groups Day 3- Gene expression profiling with real-time PCR Multiplate measurements Normalization Introduc...
http://technologynetworks.com/eventsid.aspx?id=152260
*  Transient Cerebral Ischemia disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clin
DRD1 antibody KMO antibody KYNU antibody ODC1 antibody ADORA1 antibody PLA2G2A antibody CAMK2G antibody RPS27A antibody. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. 1 ischemia 31.5 KMO, ADORA1, PLA2G2A, CAMK2G. 3 brain ischemia 30.5 ADORA1, CAMK2G. 5 stroke, ischemic 29.6 ADORA1, PLA2G2A, CAMK2G, ODC1. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classifications Anatomical Context Animal Models Compounds Drugs & Therapeutics Expression Genes Genetic Tests GO Terms Pathways Products Publications Related Diseases Sources Summaries Symptoms Variations Top Bottom. Jump to section Aliases & Classi...
http://malacards.org/card/transient_cerebral_ischemia
*  GEN News Highlights Related To | GEN
The Pons Asinorum of Diagnostic Genomics. Analysis of the RNA-Seq and SCA Publication Landscape. The Pons Asinorum of Diagnostic Genomics. Analysis of the RNA-Seq and SCA Publication Landscape. RNA Splicing Factor Linked with Causes of Breast Cancer. Analysis of the RNA-Seq and SCA Publication Landscape RNA-Seq and SCA Could Have a... Position in DNA Testing with $85.4M Purchase of Orchid Cellmark Protagen Taps Scienion for Biomarker Panel Validation Work Akonni and Seegene Combine Technologies to Develop Respiratory Pathogen MDx Platform DxTerity Acquires Cancer Gene Expression Assay IP from SourceMDx Agendia, MD Anderson, and The Netherlands Cancer Institute Ally to Improve Colon Cancer Prognosis CLC Bio to Develop Bioinformatics Solution for $4M Prostate Cancer Biomarker Project Life Technologies to Develop Companion Diagnostic for GSK’s Cancer Immunotherapy mRNA Profile Independently Predicts Prostate Cancer Prognosis Sequencing Used to Identify Patients for Cancer Clinical Trials Exosome, LMU Awarded €1M...
http://genengnews.com/more/related/gen-news-highlights/4/12417/?page=4
*  bioinformatics - How to determine the direction of regulation of a gene by comparing gene expression
... s. - Biology Stack Exchange. Biology. Biology Meta. more stack exchange communities. Stack Exchange. sign up log in tour. Help Center Detailed answers to any questions you might have. Biology Questions. Biology Stack Exchange is a question and answer site for biology researchers, academics, and students. How to determine the direction of regulation of a gene by comparing gene expressions. I am just learning about the gene expressions and regulation. I am confused about how people can determine whether a gene is down-regulated or up-regulated by its gene expression. Assume we have a few samples of a gene: some of the samples are normal patients samples and rest of them are disease-infected samples. Do we determine the direction of regulation of a gene by the ratio of gene expression of normal/disease-infected samples. For example, if the ratio of expressions is a negative value, do we say that the gene is a down-regulated gene, otherwise, it is a up-regulated gene. bioinformatics gene-expression gene-regul...
http://biology.stackexchange.com/questions/6885/how-to-determine-the-direction-of-regulation-of-a-gene-by-comparing-gene-express/6890
*  [1.0.X] Blocked the F() expression feature in r9792 from merging. · django/django@c3df5d9 · GitHub
Blocked the F expression feature in r9792 from merging. · django/django@c3df5d9 · GitHub. Skip to content. Sign up Sign in. This repository. Explore. Features. Enterprise. Pricing. Watch. 888. Star. 16,218. Fork. 6,541. django. / django. Code Pull requests. Pulse Graphs HTTPS clone URL. Subversion checkout URL. You can clone with. . HTTPS or. . Subversion. Download ZIP. Permalink. Browse files Blocked the F expression feature in r9792 from merging. git-svn-id: http://code.djangoproject.com/svn/django/branches/releases/1.0.X@9797 bcc190cf-cafb-0310-a4f2-bffc1f526a37. Loading branch information ... commit c3df5d96d283e2ed9cd37047e1e3f3d55bbf05b9. 1 parent 0f8f27f. freakboy3742 authored Jan 29, 2009. Unified. Split. Showing 0 changed files with 0 additions and 0 deletions. Toggle all file notes. 0 comments on commit c3df5d9. Please sign in to comment. Status. API. Training. Shop. Blog. About. Pricing. 2015 GitHub, Inc. Terms. Privacy. Security. Contact. Help. Something went wrong with that request. Please try ag...
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*  Recent Articles | Cancer Gene Expression And Evolution | The Scientist Magazine®| Page 4
Recent Articles. Cancer Gene Expression And Evolution. The Scientist Magazine. Page 4. The Scientist Sign In or Register. Advertisement. Thermo Scientific. The Scientist. tags: cancer gene expression x. evolution x. The Scientist cancer gene expression and evolution. Most Recent Winged Dino Found. By Bob Grant. May 1, 2015. Researchers describe a small species that may have soared through Jurassic skies on membranous wings like those of bats and flying squirrels. 0 Comments. Similar Strokes By Jenny Rood. April 29, 2015. Physics drove the convergent evolution of swimming in 22 unrelated marine species, a study suggests. 2 Comments. Citrus History By Jenny Rood. April 16, 2015. An analysis of 34 chloroplast genomes reveals how and when modern fruit varieties evolved from a common ancestor. 0 Comments. Behavior Brief By Jenny Rood. April 8, 2015. A round-up of recent discoveries in behavior research 0 Comments. Capsule Reviews By Bob Grant. April 1, 2015. Junk DNA, Cuckoo, Sapiens, and Cool 0 Comments. Ebola Mu...
http://the-scientist.com/?articles.list/tagNo/1316,8/tags/cancer-gene-expression,evolution/pageNo/4/
*  FRCH-World Languages Classes at Bellevue College
View details for FRCH 121. Prerequisite: FRCH 121 or permission of instructor. View details for FRCH 122. Prerequisite: FRCH 121 or permission of instructor. View details for FRCH 123. Portfolio evaluation required to receive credit. View details for FRCH 131. FRCH 132 Language & Culture Immersion-Int 1st Year French. Students experience complete immersion into a 100% French-speaking on-site environment. Portfolio evaluation required to receive credit. Prerequisite: Placement determined by approved host institution and permission of instructor. View details for FRCH 132. Portfolio evaluation required to receive credit. Prerequisite: Placement by approved host institution and permission of instructor. View details for FRCH 133. FRCH 194 Special Topics in French. Allows specialized or in-depth study of subjects related to French language and culture. Prerequisite: Current French students. View details for FRCH 194. FRCH 195 Special Topics in French. Allows specialized or in-depth study of subjects related to Fr...
http://bellevuecollege.edu/classes/All/FRCH?YearQuarter=All&letter=F
*  FRCH-World Languages Classes at Bellevue College
View details for FRCH 121. Prerequisite: FRCH 121 or permission of instructor. View details for FRCH 122. Prerequisite: FRCH 121 or permission of instructor. View details for FRCH 123. Portfolio evaluation required to receive credit. View details for FRCH 131. FRCH 132 Language & Culture Immersion-Int 1st Year French. Students experience complete immersion into a 100% French-speaking on-site environment. Portfolio evaluation required to receive credit. Prerequisite: Placement determined by approved host institution and permission of instructor. View details for FRCH 132. Portfolio evaluation required to receive credit. Prerequisite: Placement by approved host institution and permission of instructor. View details for FRCH 133. FRCH 194 Special Topics in French. Allows specialized or in-depth study of subjects related to French language and culture. Prerequisite: Current French students. View details for FRCH 194. FRCH 195 Special Topics in French. Allows specialized or in-depth study of subjects related to Fr...
http://bellevuecollege.edu/classes/All/FRCH?YearQuarter=All&letter=R
*  FRCH-World Languages Classes at Bellevue College
View details for FRCH 121. Prerequisite: FRCH 121 or permission of instructor. View details for FRCH 122. Prerequisite: FRCH 121 or permission of instructor. View details for FRCH 123. Portfolio evaluation required to receive credit. View details for FRCH 131. FRCH 132 Language & Culture Immersion-Int 1st Year French. Students experience complete immersion into a 100% French-speaking on-site environment. Portfolio evaluation required to receive credit. Prerequisite: Placement determined by approved host institution and permission of instructor. View details for FRCH 132. Portfolio evaluation required to receive credit. Prerequisite: Placement by approved host institution and permission of instructor. View details for FRCH 133. FRCH 194 Special Topics in French. Allows specialized or in-depth study of subjects related to French language and culture. Prerequisite: Current French students. View details for FRCH 194. FRCH 195 Special Topics in French. Allows specialized or in-depth study of subjects related to Fr...
https://bellevuecollege.edu/classes/All/FRCH?YearQuarter=All
*  Multi-Organ Expression Profiling Uncovers a Gene Module in Coronary Artery Disease Involving Transen
www.plosgenetics.org1 December 2009. Of these 60 tissue clusters, 15 were identified from the liver gene expression profiles, 11 from skeletal muscle profiles, 20 from visceral fat profiles, and 14 from gene expression profiles of the atherosclerotic arterial wall Table S1. Two of the 60 tissue clusters n=49 RefSeqs/48 genes, Table S2, 90% CI: 28–49 and n=59 RefSeqs/genes, Table S3, 90% CI: 38–59, respectively segregated the patients into groups according to the extent of coronary stenosis: one cluster in atherosclerotic arterial wall and one in visceral fat P=0.008 Figure 2 and P=0.00015 Figure 3, respectively. doi:10.1371/journal.pgen.1000754.t001 Atherosclerosis Module PLoS Genetics. doi:10.1371/journal.pgen.1000754.g001 Atherosclerosis Module PLoS Genetics. doi:10.1371/journal.pgen.1000754.g002 Atherosclerosis Module PLoS Genetics. doi:10.1371/journal.pgen.1000754.g003 Atherosclerosis Module PLoS Genetics. doi:10.1371/journal.pgen.1000754.g004 Atherosclerosis Module PLoS Genetics. Seven genes were found i...
http://researchgate.net/publication/40484438_Multi-Organ_Expression_Profiling_Uncovers_a_Gene_Module_in_Coronary_Artery_Disease_Involving_Transendothelial_Migration_of_Leukocytes_and_LIM_Domain_Binding_2_The_Stockholm_Atherosclerosis_Gene_Expression_(STAGE)_Study
*  Recent Articles | Cancer Gene Expression And Neuroscience | The Scientist Magazine®| Page 9
Recent Articles. Cancer Gene Expression And Neuroscience. The Scientist Magazine. Page 9. The Scientist Sign In or Register. Advertisement. PerkinElmer. The Scientist. tags: cancer gene expression x. neuroscience x. The Scientist cancer gene expression and neuroscience. Most Recent Bouncing Back By Ashley P. Taylor. February 1, 2015. In mice, a transcriptional regulator, -catenin, activates a microRNA-processing pathway in the nucleus accumbens to promote resilience to social stress. 0 Comments. Capsule Reviews By Bob Grant. February 1, 2015. Touch, The Altruistic Brain, Is Shame Necessary., and Future Arctic 0 Comments. Brain Cells Behind Overeating By Anna Azvolinsky. January 29, 2015. Scientists have defined mouse neurons responsible for excessive food consumption at an unprecedented level of detail. 1 Comment. Filming the Nematode Brain By Jef Akst. January 26, 2015. Researchers record the first whole-brain videos of an unrestrained animal, viewing neural activity as a roundworm moved freely around a Petr...
http://the-scientist.com/?articles.list/tagNo/1316,11/tags/cancer-gene-expression,neuroscience/pageNo/9/
*  GEN News Highlights Related To | GEN
FDA Nominee Driven by "Data, Data, Data". The Pons Asinorum of Diagnostic Genomics. Analysis of the RNA-Seq and SCA Publication Landscape. FDA Nominee Driven by "Data, Data, Data". The Pons Asinorum of Diagnostic Genomics. Analysis of the RNA-Seq and SCA Publication Landscape. GEN News Highlights Related to Merck Serono, Compugen Establish Biomarkers Firm Neviah Genomics Ultra-Fast Software Developed to Scan the Human Genome Roche Acquires Signature Diagnostics Qiagen Acquires Novel Circulating Tumor Cell Technology for Liquid Biopsies Biopharmas Team Up with U.K.'s 100,000 Genomes Project Illumina Joins Cancer Testing Initiative MDx Health Buys NovioGendix for Up to $8.8M Early Circulating Lung Cancer DNA Found by Hopkins Team Axela Takes Over Xceed for Ziplex Automated Gene-Expression Analysis Platform ChipDX Finds 163-Gene Signature that Predicts Early-Stage Colon Cancer Progression IBBL and WaferGen Enter Research and Equipment Collaboration Pfizer and DiaGenic Collaborate on Blood-Based Gene-Expression S...
http://genengnews.com/more/related/gen-news-highlights/4/27628/
*  https://www.jetbrains.com/help/profiler/2016.1/Studying Profiling Results Performance Forecasting.html
... => https://www.jetbrains.com/help/profiler/2016.1...
https://jetbrains.com/help/profiler/2016.1/Studying_Profiling_Results__Performance_Forecasting.html
*  Circulomics Ligo-miR EZ microRNA Assay Kit
... ...............small technologies, big advances. Ligo-miR EZ Assay Kit Advanced Ligo-miR Tools Early Access Program. Ligo-miR EZ 19+5 Assay Kit* The Ligo-miR EZ assay kit contains of all probes, enzymes, and buffers necessary to perform 24-plex microRNA profiling on 50 samples. Multiplex analysis of 24 microRNA is accurately performed in each reaction using our innovative PCR-free, ligation assay. Ligo-miR EZ 19+5 uses a semi-custom panel consisting of 19 fixed microRNA and 5 user selectable microRNA. The assay is performed in 3 simple steps: First, the capture ligation reagents are added to an RNA sample and incubated for 1 hour. Each lane represents a single sample where each microRNA is accurately identified by band position and expression level is precisely determined by band intensity. High Sensitivity 1 1e-18 moles sensitivity using fluorescent PAGE detection no PCR 50X linear amplification Linear quantification across 4-5 orders of magnitude dynamic range Absolute expression levels are easily obta...
http://circulomics.com/prod_ligomirez.html
*  Cancer/Tumor Profiling Market (Personalized Medicine, Biomarker Discovery, Prognosis, Research) Wort
Cancer/Tumor Profiling Market Personalized Medicine, Biomarker Discovery, Prognosis, Research Worth $35.03 Billion by 2018 – New Report by MarketsandMarkets. Cancer/Tumor Profiling Market Personalized Medicine, Biomarker Discovery, Prognosis, Research Worth $35.03 Billion by 2018 – New Report by MarketsandMarkets. Share Article. Cancer/Tumor Profiling Market report categorizes the global cancer/tumor profiling market into geography, applications, technologies, and segment types. http://www.marketsandmarkets.com/Market-Reports/cancer-tumor-profiling-market-1250.html. MarketsandMarkets. This report studies the global cancer/tumor profiling market, with forecast to 2018. Cancer/Tumor profiling is one such technology with the exact potential to revolutionize cancer diagnostics and therapeutics in the healthcare industry. This market research report evaluates the global market of cancer/tumor profiling by geography, applications, technologies, and segment types. The global cancer/tumor profiling market was valued ...
http://prweb.com/releases/cancer-tumor-profiling/market/prweb11176976.htm
*  .. NanoString and Focused Gene Expression .. About Dale Yuzuki .. Post navigation
NanoString and Focused Gene Expression. Its market is the focused gene expression market, which is a subset of the microarray gene expression one. More recently High Throughput Genomics molecular is chasing this focused gene set market. And their assay pricing is complicated: for their standard panels, the price / sample depends on the number of assays ordered, anywhere from 12 to 384 sample’s worth, and of course different panels have different number of genes on them, so it is difficult to come up with a simple formula to describe the pricing model. Trying to simplify it, it costs on the order of $0.50 to $1.00 per gene depending on the number of genes higher is less expensive and number of assays ordered more samples is less expensive. So for example a customer orders a Human Cancer panel of 230 genes; it will cost from $143 per sample up to $270 per sample, depending on the number of assays ordered. The assay offers limited hands-on time only 15 minutes per sample – it is as simple as mixing 100ng of tota...
http://yuzuki.org/nanostring-and-focused-gene-expression/

Gene signature: A gene signature is a group of genes in a cell whose combined expression patternItadani H, Mizuarai S, Kotani H. Can systems biology understand pathway activation?Cellular microarray: A cellular microarray is a laboratory tool that allows for the multiplex interrogation of living cells on the surface of a solid support. The support, sometimes called a "chip", is spotted with varying materials, such as antibodies, proteins, or lipids, which can interact with the cells, leading to their capture on specific spots.Mature messenger RNA: Mature messenger RNA, often abbreviated as mature mRNA is a eukaryotic RNA transcript that has been spliced and processed and is ready for translation in the course of protein synthesis. Unlike the eukaryotic RNA immediately after transcription known as precursor messenger RNA, it consists exclusively of exons, with all introns removed.De novo transcriptome assembly: De novo transcriptome assembly is the method of creating a transcriptome without the aid of a reference genome.Eukaryotic transcription: Eukaryotic transcription is the elaborate process that eukaryotic cells use to copy genetic information stored in DNA into units of RNA replica. Gene transcription occurs in both eukaryotic and prokaryotic cells.Pituitary-specific positive transcription factor 1: POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1), also known as POU1F1, is a transcription factor for growth hormone.Generalizability theory: Generalizability theory, or G Theory, is a statistical framework for conceptualizing, investigating, and designing reliable observations. It is used to determine the reliability (i.Squamosa promoter binding protein: The SQUAMOSA promoter binding protein-like (SBP or SPL) family of transcription factors are defined by a plant-specific DNA-binding domain. The founding member of the family was identified based on its specific in vitro binding to the promoter of the snapdragon SQUAMOSA gene.YjdF RNA motifSequence clustering: In bioinformatics, sequence clustering algorithms attempt to group biological sequences that are somehow related. The sequences can be either of genomic, "transcriptomic" (ESTs) or protein origin.Biological network: A biological network is any network that applies to biological systems. A network is any system with sub-units that are linked into a whole, such as species units linked into a whole food web.Cancer biomarkers: A cancer biomarker refers to a substance or process that is indicative of the presence of cancer in the body. A biomarker may be a molecule secreted by a tumor or a specific response of the body to the presence of cancer.GC box: In molecular biology, a GC box is a distinct pattern of nucleotides found in the promoter region of some eukaryotic genes upstream of the TATA box and approximately 110 bases upstream from the transcription initiation site. It has a consensus sequence GGGCGG which is position dependent and orientation independent.Symmetry element: A symmetry element is a point of reference about which symmetry operations can take place. In particular, symmetry elements can be centers of inversion, axes of rotation and mirror planes.MicroRNA and microRNA target database: This microRNA database and microRNA targets databases is a compilation of databases and web portals and servers used for microRNAs and their targets. MicroRNAs (miRNAs) represent an important class of small non-coding RNAs (ncRNAs) that regulate gene expression by targeting messenger RNAs.Coles PhillipsPSI Protein Classifier: PSI Protein Classifier is a program generalizing the results of both successive and independent iterations of the PSI-BLAST program. PSI Protein Classifier determines belonging of the found by PSI-BLAST proteins to the known families.Thermal cyclerOntario Genomics Institute: The Ontario Genomics Institute (OGI) is a not-for-profit organization that manages cutting-edge genomics research projects and platforms.The Ontario Genomics Institute OGI also helps scientists find paths to the marketplace for their discoveries and the products to which they lead, and it works through diverse outreach and educational activities to raise awareness and facilitate informed public dialogue about genomics and its social impacts.Phenotype microarray: The phenotype microarray approach is a technology for high-throughput phenotyping of cells.RV coefficient: In statistics, the RV coefficientBreast cancer classification: Breast cancer classification divides breast cancer into categories according to different schemes, each based on different criteria and serving a different purpose. The major categories are the histopathological type, the grade of the tumor, the stage of the tumor, and the expression of proteins and genes.Silent mutation: Silent mutations are mutations in DNA that do not significantly alter the phenotype of the organism in which they occur. Silent mutations can occur in non-coding regions (outside of genes or within introns), or they may occur within exons.Clonal Selection Algorithm: In artificial immune systems, Clonal selection algorithms are a class of algorithms inspired by the clonal selection theory of acquired immunity that explains how B and T lymphocytes improve their response to antigens over time called affinity maturation. These algorithms focus on the Darwinian attributes of the theory where selection is inspired by the affinity of antigen-antibody interactions, reproduction is inspired by cell division, and variation is inspired by somatic hypermutation.Extracellular: In cell biology, molecular biology and related fields, the word extracellular (or sometimes extracellular space) means "outside the cell". This space is usually taken to be outside the plasma membranes, and occupied by fluid.DNA-binding proteinParaHox: The ParaHox gene cluster is an array of homeobox genes (involved in morphogenesis, the regulation of patterns of anatomical development) from the Gsx, Xlox (Pdx) and Cdx gene families.AcheiropodiaPeptide microarray: A peptide microarray (also commonly known as peptide chip or peptide epitope microarray) is a collection of peptides displayed on a solid surface, usually a glass or plastic chip. Peptide chips are used by scientists in biology, medicine and pharmacology to study binding properties and functionality and kinetics of protein-protein interactions in general.Library (biology): In molecular biology, a library is a collection of DNA fragments that is stored and propagated in a population of micro-organisms through the process of molecular cloning. There are different types of DNA libraries, including cDNA libraries (formed from reverse-transcribed RNA), genomic libraries (formed from genomic DNA) and randomized mutant libraries (formed by de novo gene synthesis where alternative nucleotides or codons are incorporated).Temporal analysis of products: Temporal Analysis of Products (TAP), (TAP-2), (TAP-3) is an experimental technique for studyingMatrix model: == Mathematics and physics ==Liver sinusoid: A liver sinusoid is a type of sinusoidal blood vessel (with fenestrated, discontinuous endothelium) that serves as a location for the oxygen-rich blood from the hepatic artery and the nutrient-rich blood from the portal vein.SIU SOM Histology GIGross pathology: Gross pathology refers to macroscopic manifestations of disease in organs, tissues, and body cavities. The term is commonly used by anatomical pathologists to refer to diagnostically useful findings made during the gross examination portion of surgical specimen processing or an autopsy.DNA sequencer: A DNA sequencer is a scientific instrument used to automate the DNA sequencing process. Given a sample of DNA, a DNA sequencer is used to determine the order of the four bases: G (guanine), C (cytosine), A (adenine) and T (thymine).Laser-induced breakdown spectroscopy: Laser-induced breakdown spectroscopy (LIBS) is a type of atomic emission spectroscopy which uses a highly energetic laser pulse as the excitation source. The laser is focused to form a plasma, which atomizes and excites samples.ChIP-exo: ChIP-exo is a chromatin immunoprecipitation based method for mapping the locations at which a protein of interest (transcription factor) binds to the genome. It is a modification of the ChIP-seq protocol, improving the resolution of binding sites from hundreds of base pairs to almost one base pair.List of sequenced eukaryotic genomesRepressor: In molecular genetics, a repressor is a DNA- or RNA-binding protein that inhibits the expression of one or more genes by binding to the operator or associated silencers. A DNA-binding repressor blocks the attachment of RNA polymerase to the promoter, thus preventing transcription of the genes into messenger RNA.Start point (yeast): The Start checkpoint is a major cell cycle checkpoint in yeast. The Start checkpoint ensures irreversible cell-cycle entry even if conditions later become unfavorable.Spatiotemporal gene expressionIroquois homeobox factor: Iroquois homeobox factors are a family of homeodomain transcription factors that play a role in many developmental processes.Tissue microarray: 215px|thumb|right|A Tissue MicroArray BlockMir-127: mir-127 microRNA is a short non-coding RNA molecule with interesting overlapping gene structure. miR-127 functions to regulate the expression levels of genes involved in lung development, placental formation and apoptosis.Dermal fibroblast: Dermal fibroblasts are cells within the dermis layer of skin which are responsible for generating connective tissue and allowing the skin to recover from injury. Using organelles (particularly the rough endoplasmic reticulum), dermal fibroblasts generate and maintain the connective tissue which unites separate cell layers.Proteomics Standards Initiative: The Proteomics Standards Initiative (PSI) is a working group of Human Proteome Organization. It aims to define data standards for proteomics in order to facilitate data comparison, exchange and verification.RNAi-Based Identification System and interference of Specific Cancer Cells: A “classifier” was created to classify cells by identifying specific characteristics of Cervical Cancer. These characteristics were consistent with HeLa cells, which served as the target cell line for cell death.Biomarkers of aging: Biomarkers of aging are biomarkers that better predict functional capacity at a later age than chronological age. Stated another way, biomarkers of aging would give the true "biological age", which may be different from the chronological age.

(1/41147) Sensitivity issues in DNA array-based expression measurements and performance of nylon microarrays for small samples.

DNA or oligonucleotide arrays are widely used for large-scale expression measurements, using various implementations: macroarrays in which DNA is spotted onto nylon membranes of relatively large dimensions (with radioactive detection) on the one hand; microarrays on glass slides and oligonucleotide chips, both used with fluorescent probes, on the other hand. Nylon micro-arrays with colourimetric detection have also been described recently. The small physical dimensions of miniaturized systems allow small hybridization volumes (2-100 microl) and provide high probe concentrations, in contrast to macroarrays. We show, however, that actual sensitivity (defined as the amount of sample necessary for detection of a given mRNA species) is in fact similar for all these systems and that this is mostly due to the very different amounts of target material present on the respective arrays. We then demonstrate that the combination of nylon microarrays with(33)P-labelled radioactive probes provides 100-fold better sensitivity, making it possible to perform expression profiling experiments using submicrogram amounts of unamplified total RNA from small biological samples. This has important implications in basic and clinical research and makes this alternative approach particularly suitable for groups operating in an academic context.  (+info)

(2/41147) On-line monitoring of gene expression.

Gene expression in cultures of Escherichia coli has been determined in situ and on-line by the use of an electrochemical sensor. Intact bacteria were used to monitor the induction of the lacZ gene; the onset of stationary phase was also monitored, using a reporter gene fused to the RpoS-dependent promoter of the osmY gene. The technique described can in principle be used to determine the activity of any promoter, with a variety of reporter genes. This technology is non-intrusive, allows real-time monitoring of gene expression, and will be useful in the study of growth regulation and development.  (+info)

(3/41147) Computational methods for the identification of differential and coordinated gene expression.

With the first complete 'draft' of the human genome sequence expected for Spring 2000, the three basic challenges for today's bioinformatics are more than ever: (i) finding the genes; (ii) locating their coding regions; and (iii) predicting their functions. However, our capacity for interpreting vertebrate genomic and transcript (cDNA) sequences using experimental or computational means very much lags behind our raw sequencing power. If the performances of current programs in identifying internal coding exons are good, the precise 5'-->3' delineation of transcription units (and promoters) still requires additional experiments. Similarly, functional predictions made with reference to previously characterized homologues are leaving >50% of human genes unannotated or classified in uninformative categories ('kinase', 'ATP-binding', etc.). In the context of functional genomics, large-scale gene expression studies using massive cDNA tag sequencing, two-dimensional gel proteome analysis or microarray technologies are the only approaches providing genome-scale experimental information at a pace consistent with the progress of sequencing. Given the difficulty and cost of characterizing genes one by one, academic and industrial researchers are increasingly relying on those methods to prioritize their studies and choose their targets. The study of expression patterns can also provide some insight into the function, reveal regulatory pathways, indicate side effects of drugs or serve as a diagnostic tool. In this article, I review the theoretical and computational approaches used to: (i) identify genes differentially expressed (across cell types, developmental stages, pathological conditions, etc.); (ii) identify genes expressed in a coordinated manner across a set of conditions; and (iii) delineate clusters of genes sharing coherent expression features, eventually defining global biological pathways.  (+info)

(4/41147) Genome-wide expression profiling in Escherichia coli K-12.

We have established high resolution methods for global monitoring of gene expression in Escherichia coli. Hybridization of radiolabeled cDNA to spot blots on nylon membranes was compared to hybridization of fluorescently-labeled cDNA to glass microarrays for efficiency and reproducibility. A complete set of PCR primers was created for all 4290 annotated open reading frames (ORFs) from the complete genome sequence of E.coli K-12 (MG1655). Glass- and nylon-based arrays of PCR products were prepared and used to assess global changes in gene expression. Full-length coding sequences for array printing were generated by two-step PCR amplification. In this study we measured changes in RNA levels after exposure to heat shock and following treatment with isopropyl-beta-D-thiogalactopyranoside (IPTG). Both radioactive and fluorescence-based methods showed comparable results. Treatment with IPTG resulted in high level induction of the lacZYA and melAB operons. Following heat shock treatment 119 genes were shown to have significantly altered expression levels, including 35 previously uncharacterized ORFs and most genes of the heat shock stimulon. Analysis of spot intensities from hybridization to replicate arrays identified sets of genes with signals consistently above background suggesting that at least 25% of genes were expressed at detectable levels during growth in rich media.  (+info)

(5/41147) Yeast Upf proteins required for RNA surveillance affect global expression of the yeast transcriptome.

mRNAs are monitored for errors in gene expression by RNA surveillance, in which mRNAs that cannot be fully translated are degraded by the nonsense-mediated mRNA decay pathway (NMD). RNA surveillance ensures that potentially deleterious truncated proteins are seldom made. NMD pathways that promote surveillance have been found in a wide range of eukaryotes. In Saccharomyces cerevisiae, the proteins encoded by the UPF1, UPF2, and UPF3 genes catalyze steps in NMD and are required for RNA surveillance. In this report, we show that the Upf proteins are also required to control the total accumulation of a large number of mRNAs in addition to their role in RNA surveillance. High-density oligonucleotide arrays were used to monitor global changes in the yeast transcriptome caused by loss of UPF gene function. Null mutations in the UPF genes caused altered accumulation of hundreds of mRNAs. The majority were increased in abundance, but some were decreased. The same mRNAs were affected regardless of which of the three UPF gene was inactivated. The proteins encoded by UPF-dependent mRNAs were broadly distributed by function but were underrepresented in two MIPS (Munich Information Center for Protein Sequences) categories: protein synthesis and protein destination. In a UPF(+) strain, the average level of expression of UPF-dependent mRNAs was threefold lower than the average level of expression of all mRNAs in the transcriptome, suggesting that highly abundant mRNAs were underrepresented. We suggest a model for how the abundance of hundreds of mRNAs might be controlled by the Upf proteins.  (+info)

(6/41147) NORF5/HUG1 is a component of the MEC1-mediated checkpoint response to DNA damage and replication arrest in Saccharomyces cerevisiae.

Analysis of global gene expression in Saccharomyces cerevisiae by the serial analysis of gene expression technique has permitted the identification of at least 302 previously unidentified transcripts from nonannotated open reading frames (NORFs). Transcription of one of these, NORF5/HUG1 (hydroxyurea and UV and gamma radiation induced), is induced by DNA damage, and this induction requires MEC1, a homolog of the ataxia telangiectasia mutated (ATM) gene. DNA damage-specific induction of HUG1, which is independent of the cell cycle stage, is due to the alleviation of repression by the Crt1p-Ssn6p-Tup1p complex. Overexpression of HUG1 is lethal in combination with a mec1 mutation in the presence of DNA damage or replication arrest, whereas a deletion of HUG1 rescues the lethality due to a mec1 null allele. HUG1 is the first example of a NORF with important biological functional properties and defines a novel component of the MEC1 checkpoint pathway.  (+info)

(7/41147) Microarray analysis of replicative senescence.

BACKGROUND: Limited replicative capacity is a defining characteristic of most normal human cells and culminates in senescence, an arrested state in which cells remain viable but display an altered pattern of gene and protein expression. To survey widely the alterations in gene expression, we have developed a DNA microarray analysis system that contains genes previously reported to be involved in aging, as well as those involved in many of the major biochemical signaling pathways. RESULTS: Senescence-associated gene expression was assessed in three cell types: dermal fibroblasts, retinal pigment epithelial cells, and vascular endothelial cells. Fibroblasts demonstrated a strong inflammatory-type response, but shared limited overlap in senescent gene expression patterns with the other two cell types. The characteristics of the senescence response were highly cell-type specific. A comparison of early- and late-passage cells stimulated with serum showed specific deficits in the early and mid G1 response of senescent cells. Several genes that are constitutively overexpressed in senescent fibroblasts are regulated during the cell cycle in early-passage cells, suggesting that senescent cells are locked in an activated state that mimics the early remodeling phase of wound repair. CONCLUSIONS: Replicative senescence triggers mRNA expression patterns that vary widely and cell lineage strongly influences these patterns. In fibroblasts, the senescent state mimics inflammatory wound repair processes and, as such, senescent cells may contribute to chronic wound pathologies.  (+info)

(8/41147) Functional genomics: expression analysis of Escherichia coli growing on minimal and rich media.

DNA arrays of the entire set of Escherichia coli genes were used to measure the genomic expression patterns of cells growing in late logarithmic phase on minimal glucose medium and on Luria broth containing glucose. Ratios of the transcript levels for all 4,290 E. coli protein-encoding genes (cds) were obtained, and analysis of the expression ratio data indicated that the physiological state of the cells under the two growth conditions could be ascertained. The cells in the rich medium grew faster, and expression of the majority of the translation apparatus genes was significantly elevated under this growth condition, consistent with known patterns of growth rate-dependent regulation and increased rate of protein synthesis in rapidly growing cells. The cells grown on minimal medium showed significantly elevated expression of many genes involved in biosynthesis of building blocks, most notably the amino acid biosynthetic pathways. Nearly half of the known RpoS-dependent genes were expressed at significantly higher levels in minimal medium than in rich medium, and rpoS expression was similarly elevated. The role of RpoS regulation in these logarithmic phase cells was suggested by the functions of the RpoS dependent genes that were induced. The hallmark features of E. coli cells growing on glucose minimal medium appeared to be the formation and excretion of acetate, metabolism of the acetate, and protection of the cells from acid stress. A hypothesis invoking RpoS and UspA (universal stress protein, also significantly elevated in minimal glucose medium) as playing a role in coordinating these various aspects and consequences of glucose and acetate metabolism was generated. This experiment demonstrates that genomic expression assays can be applied in a meaningful way to the study of whole-bacterial-cell physiology for the generation of hypotheses and as a guide for more detailed studies of particular genes of interest.  (+info)


Does anyone know if all the Rh negative individuals express only the ce antigens of the Rh system?


I can't find information about the RhCE gene expression in Rh negative individuals.
I know almost 95% of them have the ce Rh system phenotype, but I've found people expressing C o E antigen, so I would like to know why. 
Thanks...
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Is there a relationship between the working out and gene expression?


Is it accurate that some genes become more greatly expresses or certain traits in the body become more apparent when the body develops muscle tissue through regularly working out? For example, can working out make you more perceptive or disciplined?
Also, any resources (books, articles, websites) on the topic of exercise and genetics would be really appreciated!
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I became interested in gene expression and epigenetic imprinting when I first read about it a few years ago. The human body is apparently one of only a handful of known species that are capable of altering gene expression in the course of the lifetime of a single individual. Theoretically, the more you work out, for instance, the more your body will adapt to it's new circumstances, and over time, you may indeed become more disciplined on a genetic level. Of course, what combination of genes causes this is completely unknown. 97% of DNA is refered to as junk simply because we haven't a clue what it does.

Also, the genetic makeup of your children is influenced by your behavior. Being healthy and working out will epigenetically imprint a larger musclemass and VO2 uptake capacity in your offspring.

Crazy, but true. Besides, these things have been known among cattlefarmers etc. for millenia, and humans are animals just about as much as cattle.


How does gene therapy help a cystic fibrosis sufferer?


How does gene therapy help a cystic fibrosis sufferer?

Also :

what 2 reasons may genetic testing be carried out when a couple are undergoing IVF treatment?
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Gene therapy aims to effectively replace a faulty gene. So in Cystic Fibrosis it would replace the gene (or genes) which causes the problem and hopefully make the patient much better. As for IVF some tests are done to check for chromosomal abnormalities like Down's Syndrome and other genetic problems.


How many generations can a dwarf gene be carried if you marry normal height people?


If your parents are dwarves but you came out normal and marry normal and have normal kids, the dwarf gene is still in your kids.  If your kids and generations later continue to marry and birth normal, is the dwarf gene completely wiped out?  Or can it still pop up in a child hundreds of years later?
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Yes it can pop up.  We also see the dwarf gene being expressed as simply much shorter than average height.  In other words, you could be a tall guy with a dwarf gene, and even if the mother of your child is a six foot tall woman from a family of six foot tall women, you could have a 4'7" daughter or a 5'1" son....taller than a dwarf but still showing the gene a bit.


How dominate is the Asian gene in a biracial baby?


Most Asian-white couple's I've seen have babies that look full blooded Asian. I know that the Asian gene is supposed to be extremely dominate, but how dominate is it? Can the couple have a baby that has asian features, but got curly hair from the white parents? Or does the baby either have to look full Asian or full white? Is there some sort of in-between?
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The asian gene????  Do you really think there is one gene that makes a person asian?


What is the typical facial expression of a man when he achieves orgasm?


Some men try to fake orgasm. But I know it's very hard to fake a facial expression. So maybe facial expression can tell if he's telling the truth or not 

Share your views, thanks
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People typically have an expression that resembles pain. Nerves interpret this intense experience in the same manner as pain because they don't think anything else should be able to trigger that level of stimuli, and moves the muscles accordingly.


What is the difference between a gene mutation and a chromosomal mutation?


Is a neural tube deffect a chromosomal mutation or a gene mutation?  What is the difference between the two types of mutations?
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A gene mutation is a permanent change in the DNA sequence that makes up a gene. Mutations range in size from a single DNA building block (DNA base) to a large segment of a chromosome.

A chromosomal mutation is a mutation  involving a long segment of DNA, it is a any change in the structure or arrangement of the chromosomes. These mutations can involve deletions, insertions, or inversions of sections of DNA. In some cases, deleted sections may attach to other chromosomes, disrupting both the chromosomes that loses the DNA and the one that gains it.It is  also referred to as a chromosomal rearrangement


Neural tube defects (NTDs) are common birth defects of the brain and spinal cord that include anencephaly and spina bifida (meningomyelocele). Deficiency of the vitamin folic acid raises the risk of NTDs, as does mutation of a gene for an enzyme that processes folic acid. The mutation is called the C677T.People with two copies of the T mutation are two and a half times as likely to have a NTD as people with two copies of the normal gene. Now it has been found that people with just one copy of the T gene are also at increased risk for an NTD. They are one and a half times more likely to have a NTD than people with two copies of the normal gene.

There is evidence that some mothers of infants with Down's syndrome have abnormal metabolism of folate and methyl, as well as mutations in folate genes, which are features that are also seen in neural-tube defects (NTD).


What sets off the autoimmune gene that per my doctor can cause different diseases and many forms?


I have Rheumatoid Arthritis, my brother has Psorisis and I have a sister with Diabetes.  My dad had gout, is this where the gene originated from and what sets this gene off?  I was in an accident and was diagnosed not long after with RA.
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It is still under investigation. Although, scientists have found an unexpected genetic link among three common autoimmune diseases: "psoriasis", "rheumatoid arthritis" and systemic lupus erythematosus.

The findings, being reported recently in the journal Nature Genetics, have no immediate practical effect. But by identifying a cellular path through which the three diseases are touched off, they may help biologists design new treatments.

Psoriasis affects 2 percent of Americans; rheumatoid arthritis, up to 1 percent; and systemic lupus -- which attacks the joints and can cause severe inflammation -- one-twentieth of 1 percent.

The link among the three diseases involves a PROTEIN that helps the thymus GLAND train cells of the immune system. Autoimmune diseases are caused when such cells mistakenly attack the body's own tissues.

The protein, Runx-1, controls the activity of various genes by binding to a nearby site on the DNA of the chromosomes. Last year, scientists at the University of Uppsala in Sweden reported that many patients with systemic lupus had an altered Runx-1 binding site on Chromosome 2, meaning that the Runx-1 protein could not properly control the gene next to the binding site.