A non-steroidal ESTROGEN generated when soybean products are metabolized by certain bacteria in the intestines.
3-Phenylchromones. Isomeric form of FLAVONOIDS in which the benzene group is attached to the 3 position of the benzopyran ring instead of the 2 position.
PLANT EXTRACTS and compounds, primarily ISOFLAVONES, that mimic or modulate endogenous estrogens, usually by binding to ESTROGEN RECEPTORS.
Foods made from SOYBEANS. Health benefits are ascribed to the high levels of DIETARY PROTEINS and ISOFLAVONES.
An annual legume. The SEEDS of this plant are edible and used to produce a variety of SOY FOODS.
Non-steroidal compounds with estrogenic activity.
Proteins which are present in or isolated from SOYBEANS.
An isoflavonoid derived from soy products. It inhibits PROTEIN-TYROSINE KINASE and topoisomerase-II (DNA TOPOISOMERASES, TYPE II); activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 PHASE arrest in human and murine cell lines and inhibits PROTEIN-TYROSINE KINASE.

Comparison of isoflavones among dietary intake, plasma concentration and urinary excretion for accurate estimation of phytoestrogen intake. (1/143)

Biological effects of dietary isoflavones, such as daidzein and genistein are of interest in preventive medicine. We estimated the dietary intake of isoflavones from dietary records and compared the values with the plasma concentrations and urinary excretions in Japanese middle-aged women. The dietary intake of daidzein and genistein was 64.6 and 111.6 mumol /day/capita (16.4 and 30.1 mg/day/capita), respectively. The isoflavones intake was mostly attributable to tofu, natto and miso. The median of plasma daidzein and genistein concentration was 72.46 and 206.09 nmol/L, respectively. The median of urinary excretion was 20.54 mumol /day for daidzein, 10.79 for genistein, 15.74 for equol and 1.64 for O-desmethylangolensin (O-DMA). Equol and O-DMA were excreted by 50% and 84% of all participants, respectively. Equol metabolizers were significantly lower the plasma and urinary daidzein and urinary O-DMA. The dietary intake of daidzein and genistein after the adjustment for total energy intake was significantly correlated with the urinary excretion (r = 0.365 for daidzein and r = 0.346 for genistein) and plasma concentration (r = 0.335 for daidzein and r = 0.429 for genistein). The plasma concentration of isoflavones was also significantly correlated with the urinary excretion. We conclude that in epidemiological studies measurements of plasma concentration or urinary excretion of these isoflavones are useful biomarkers of dietary intake and important for studies on their relation to human health.  (+info)

Premenopausal equol excretors show plasma hormone profiles associated with lowered risk of breast cancer. (2/143)

Increased urinary excretion of equol, a metabolite of the isoflavone daidzein, has been associated with a reduced risk of breast cancer. This risk reduction has generally been presumed to be a consequence of increased isoflavone consumption. However, only 30-40% of the population excretes more than trace amounts of equol, regardless of isoflavone intake. Accordingly, we hypothesized that the observed apparent protective effect of equol is at least in part attributable to hormonal differences between equol excretors and non-excretors, and that these differences are largely independent of isoflavone intake. We measured plasma hormone and sex hormone binding globulin (SHBG) concentrations in 14 normally cycling premenopausal women during each of three diet periods in which they consumed differing isoflavone doses (0.15, 1.0, and 2.0 mg/kg of body weight/day) as a component of soy protein isolate. The plasma hormone and SHBG concentrations of equol excretors (n = 5) were then compared with those of the non-excretors (n = 9). Results showed that even at the lowest dose, urinary equol excretion values for excretors far exceeded those for non-excretors consuming the highest dose. At all doses, equol excretors generally had lower concentrations of estrone, estrone-sulfate, testosterone, androstenedione, dehydroepiandrosterone (DHEA), DHEA-sulfate, and cortisol and higher concentrations of SHBG and midluteal progesterone, a hormonal pattern overall consistent with lowered breast cancer risk. In conclusion, the association of equol excretion and lowered breast cancer risk may largely reflect the tendency of equol excretors to have more favorable hormonal profiles, as opposed to merely reflecting increased isoflavone intake. Equol may be a marker for the presence of colonic bacterial enzymatic activity that increases fecal steroid excretion. Alternatively, equol itself, even with very modest isoflavone intake, may exert beneficial effects on the regulation of endogenous hormones.  (+info)

Isoflavone aglycone-rich extract without soy protein attenuates atherosclerosis development in cholesterol-fed rabbits. (3/143)

The antiatherogenic effect of soy protein with intact isoflavones is well established, but the effects of isoflavones without soy protein have not been determined. We investigated the antiatherogenic effect of an isoflavone aglycone-rich extract (containing 429.4 mg/g isoflavone aglycones) without soy protein from fermented soy in cholesterol-fed rabbits. We fed 12-wk-old New Zealand white male rabbits diets containing 1 g/100 g cholesterol with 0, 0.33 or 1 g/100 g isoflavone aglycones for 8 wk. We also fed the rabbits a diet containing 1 g/100 g cholesterol with 1.09 g/100 g soy saponin-rich extract, a component other than isoflavone aglycones in the isoflavone aglycone-rich extract. Controls did not consume cholesterol, isoflavone aglycones or saponins. The isoflavone aglycone- and saponin-rich extracts did not affect the serum lipid profile of cholesterol-fed rabbits. The serum concentration of daidzein in its conjugated form was significantly higher in the high isoflavone group than in the low isoflavone group. The level of cholesteryl ester hydroperoxide (ChE-OOH) induced by CuSO(4) in plasma in the high isoflavone group was significantly less than that in the cholesterol group, and the ChE-OOH levels of LDL in the low and high isoflavone groups were significantly less than those in the cholesterol group. The ChE-OOH levels in plasma and LDL in the saponin group did not differ from the cholesterol group. In the aortic arch, the cholesterol concentration was significantly lower in the high isoflavone group, and malondialdehyde concentration was significantly lower in the low and high isoflavone groups compared with the cholesterol group; however these concentrations in the saponin group did not differ from those in the cholesterol group. The atherosclerotic lesion area of the aortic arch was significantly lower in the isoflavone groups (26.3% lower in the low isoflavone group and 36.9% lower in the high isoflavone group) than in the cholesterol group. The lesion areas were not different in the soy saponin and cholesterol groups. Immunohistochemical analysis revealed fewer oxidized LDL-positive macrophage-derived foam cells in atherosclerotic lesions in the aortic arch of isoflavone groups compared with that of the cholesterol group. These results suggest that the antioxidative action of isoflavones and their antioxidative metabolites inhibit the oxidation of LDL, thereby exerting an antiatherosclerotic effect.  (+info)

Wheat bran and soy protein feeding do not alter urinary excretion of the isoflavan equol in premenopausal women. (4/143)

The capacity to convert the soy isoflavone daidzein to equol in vivo is presumably determined by an individual's intestinal microfloral populations; however, diet may also influence this conversion. The objectives of the present study were to determine whether a 1-mo supplementation of dietary fiber as wheat bran increases urinary equol excretion in equol excreters and stimulates equol production in nonexcreters and whether longer-term soy isoflavone intake increases equol production or alters overall urinary isoflavone excretion. First, we screened 74 women, ages 20-40 y, and determined their equol-excreter status. In these women, health and lifestyle patterns and habitual dietary intake did not differ according to equol-excreter status. Next, 26 of the women (13 equol excreters and 13 nonexcreters) were assigned (blocked on equol-excreter status) to either longer-term (1 mo) or short-term (4 d) soy protein supplementation. Within each soy treatment group, women participated in two 1-mo intervention periods (the exact length was determined by each woman's menstrual cycle) during which they consumed their usual diets supplemented daily with either 0 or 16 g dietary fiber in a randomized crossover design. A 1-mo washout period separated the two diet periods. Among the 19 women who completed both periods, fiber supplementation did not increase equol production in equol excreters or nonexcreters. In addition, isoflavonoid excretion did not differ by fiber dose or length of soy intervention. These results suggest that a daily 16 g-fiber dose as wheat bran and the addition of soy protein do not alter significantly the capacity of colonic microflora to produce equol.  (+info)

Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements. (5/143)

The pharmacokinetic behavior of naturally occurring isoflavones has been determined for the first time in healthy adults. We compared plasma kinetics of pure daidzein, genistein and their beta-glycosides administered as a single-bolus dose to 19 healthy women. This study demonstrates differences in the pharmacokinetics of isoflavone glycosides compared with their respective beta-glycosides. Although all isoflavones are efficiently absorbed from the intestinal tract, there are striking differences in the fate of aglycones and beta-glycosides. Mean time to attain peak plasma concentrations (t(max)) for the aglycones genistein and daidzein was 5.2 and 6.6 h, respectively, whereas for the corresponding beta-glycosides, the t(max) was delayed to 9.3 and 9.0 h, respectively, consistent with the residence time needed for hydrolytic cleavage of the glycoside moiety for bioavailability. The apparent volume of distribution of isoflavones confirms extensive tissue distribution after absorption. Plasma genistein concentrations are consistently higher than daidzein when equal amounts of the two isoflavones are administered, and this is accounted for by the more extensive distribution of daidzein (236 L) compared with genistein (161 L). The systemic bioavailability of genistein [mean AUC = 4.54 microg/(mL x h)] is much greater than that of daidzein [mean AUC = 2.94 microg/(mL x h)], and bioavailability of these isoflavones is greater when ingested as beta-glycosides rather than aglycones as measured from the area under the curve of the plasma appearance and disappearance concentrations. The pharmacokinetics of methoxylated isoflavones show distinct differences depending on the position of the methoxyl group in the molecule. Glycitin, found in two phytoestrogen supplements, underwent hydrolysis of the beta-glycoside moiety and little further biotransformation, leading to high plasma glycitein concentrations. Biochanin A and formononetin, two isoflavones found in one phytoestrogen supplement, were rapidly and efficiently demethylated, resulting in high plasma genistein and daidzein concentrations typically observed after the ingestion of soy-containing foods. These differences in pharmacokinetics and metabolism have implications for clinical studies because it cannot be assumed that all isoflavones are comparable in their pharmacokinetics and bioavailability. An analysis of 33 phytoestrogen supplements and extracts revealed considerable differences in the isoflavone content from that claimed by the manufacturers. Plasma concentrations of isoflavones show marked qualitative and quantitative differences depending on the type of supplement ingested. These studies indicate a need for improvement in quality assurance and standardization of such products.  (+info)

A combination of dietary fructooligosaccharides and isoflavone conjugates increases femoral bone mineral density and equol production in ovariectomized mice. (6/143)

Fructooligosaccharides (FOS) stimulate the growth of bifidobacteria, which cleave isoflavone conjugates to yield the corresponding aglycones and metabolites. In a previous study, FOS modified the absorption and enterohepatic recirculation of isoflavones in rats. In the present study, we determined the effect of the combination of dietary FOS and isoflavone conjugates on bone mass in ovariectomized (OVX) and surgical control mice. After undergoing OVX or sham operation, female ddY mice (8 wk old, n = 64) were randomly assigned to four groups: a purified control diet (AIN-93G) group, a FOS diet (AIN-93G + 5% FOS) group, an isoflavone diet (AIN-93G + 0.2% isoflavone conjugates) group, or a FOS and isoflavone diet (AIN-93G + 5% FOS + 0.2% isoflavone conjugates) group. After 6 wk, the mice were killed and the blood and femora were sampled immediately. In OVX mice, both isoflavone conjugates and FOS prevented femoral bone loss. An additive effect of dietary isoflavone conjugates and FOS was observed by dual-energy X-ray absorptiometry in the distal part of the femur and in trabecular bone, by peripheral quantitative computed tomography. Moreover, FOS increased cecal beta-glucosidase activity and equol production from daidzein in both OVX and surgical control mice fed isoflavone conjugates. These results suggest that FOS increase the bioavailability of isoflavones, leading to cooperative effects in the prevention of osteopenia in OVX mice.  (+info)

Phytoestrogen concentrations in serum from Japanese men and women over forty years of age. (7/143)

Asian individuals have much lower incidences of prostate and breast cancer than populations from Western developed countries. They also consume a lower fat, higher fiber diet, with a large intake of phytoestrogens. These phytoestrogens may protect against hormone-dependent cancers and other diseases. Our study used established gas chromatography-mass spectrometry (GC-MS) methodologies to measure the concentrations of four phytoestrogens (daidzein, genistein, equol and enterolactone) in serum samples obtained from Japanese men (n = 102) and women (n = 125) > 40 y old. The results were compared with those obtained with samples from the UK. The Japanese men and women had higher (P < 0.001) concentrations of circulating daidzein, genistein and equol than individuals from the UK. The mean concentration of genistein in Japanese men, for example, was 492.7 nmol/L, compared with 33.2 nmol/L in men from the UK. The two populations, however, had similar serum concentrations of enterolactone. Furthermore, 58% of the Japanese men and 38% of the Japanese women had equol concentrations > 20 nmol/L, compared with none of the UK men and 2.2% of the UK women. These results support previously published GC-MS results from studies with low numbers of samples.  (+info)

The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones. (8/143)

Equol [7-hydroxy-3-(4'-hydroxyphenyl)-chroman] is a nonsteroidal estrogen of the isoflavone class. It is exclusively a product of intestinal bacterial metabolism of dietary isoflavones and it possesses estrogenic activity, having affinity for both estrogen receptors, ERalpha and ERbeta. Equol is superior to all other isoflavones in its antioxidant activity. It is the end product of the biotransformation of the phytoestrogen daidzein, one of the two main isoflavones found in abundance in soybeans and most soy foods. Once formed, it is relatively stable; however, equol is not produced in all healthy adults in response to dietary challenge with soy or daidzein. Several recent dietary intervention studies examining the health effects of soy isoflavones allude to the potential importance of equol by establishing that maximal clinical responses to soy protein diets are observed in people who are good "equol-producers." It is now apparent that there are two distinct subpopulations of people and that "bacterio-typing" individuals for their ability to make equol may hold the clue to the effectiveness of soy protein diets in the treatment or prevention of hormone-dependent conditions. In reviewing the history of equol, its biological properties, factors influencing its formation and clinical data, we propose a new paradigm. The clinical effectiveness of soy protein in cardiovascular, bone and menopausal health may be a function of the ability to biotransform soy isoflavones to the more potent estrogenic isoflavone, equol. The failure to distinguish those subjects who are "equol-producers" from "nonequol producers" in previous clinical studies could plausibly explain the variance in reported data on the health benefits of soy.  (+info)

Equol is a metabolite produced by intestinal bacteria that can metabolize the soy isoflavone daidzein. It has been studied for its potential role in various health outcomes, such as reducing menopause symptoms and protecting against certain types of cancer. However, not all individuals have the ability to produce equol, and its effects on human health are still a subject of ongoing research.

Isoflavones are a type of plant-derived compounds called phytoestrogens, which have a chemical structure similar to human estrogen. They are found in various plants, particularly in soybeans and soy products. Isoflavones can act as weak estrogens or anti-estrogens in the body, depending on the levels of natural hormones present. These compounds have been studied for their potential health benefits, including reducing menopausal symptoms, improving cardiovascular health, and preventing certain types of cancer. However, more research is needed to fully understand their effects and safety.

Phytoestrogens are compounds found in plants that have estrogen-like properties. They can bind to and activate or inhibit the action of estrogen receptors in the body, depending on their structure and concentration. Phytoestrogens are present in a variety of foods, including soy products, nuts, seeds, fruits, and vegetables.

Phytoestrogens have been studied for their potential health benefits, such as reducing the risk of hormone-dependent cancers (e.g., breast cancer), improving menopausal symptoms, and promoting bone health. However, their effects on human health are complex and not fully understood, and some studies suggest that high intake of phytoestrogens may have adverse effects in certain populations or under specific conditions.

It is important to note that while phytoestrogens can mimic the effects of estrogen in the body, they are generally weaker than endogenous estrogens produced by the human body. Therefore, their impact on hormonal balance and health outcomes may vary depending on individual factors such as age, sex, hormonal status, and overall diet.

Soy foods are food products made from soybeans, which are a rich source of plant-based protein, fiber, and various beneficial compounds like isoflavones. Examples of soy foods include tofu, tempeh, soymilk, edamame (immature soybeans), soy flour, and textured vegetable protein (TVP). Soy products can be used as alternatives to animal-based proteins and can be incorporated into a variety of dishes, such as stir-fries, soups, smoothies, and baked goods. It's important to note that some people may have allergies to soy or sensitivities to its phytoestrogens, which can affect hormone balance in the body.

I'm sorry for any confusion, but "soybeans" are not a medical term. They are a type of legume that is commonly used in agriculture and food production. The medical community might discuss soybeans in the context of nutrition or allergies, but there isn't a formal medical definition for this term.

Here's some general information: Soybeans, scientifically known as Glycine max, are native to East Asia and are now grown worldwide. They are a significant source of plant-based protein and oil. Soybeans contain various nutrients, including essential amino acids, fiber, B vitamins, and minerals like calcium, iron, magnesium, and zinc. They are used in various food products such as tofu, soy milk, tempeh, and miso. Additionally, soybeans are also used in the production of industrial products, including biodiesel, plastics, and inks. Some people may have allergic reactions to soybeans or soy products.

Non-steroidal estrogens are a class of compounds that exhibit estrogenic activity but do not have a steroid chemical structure. They are often used in hormone replacement therapy and to treat symptoms associated with menopause. Examples of non-steroidal estrogens include:

1. Phytoestrogens: These are plant-derived compounds that have estrogenic activity. They can be found in various foods such as soy, nuts, seeds, and some fruits and vegetables.
2. Selective Estrogen Receptor Modulators (SERMs): These are synthetic compounds that act as estrogen receptor agonists or antagonists, depending on the target tissue. Examples include tamoxifen, raloxifene, and toremifene. They are used in the treatment of breast cancer and osteoporosis.
3. Designer Estrogens: These are synthetic compounds that have been specifically designed to mimic the effects of estrogen. They are often used in research but have not been approved for clinical use.

It is important to note that non-steroidal estrogens can also have side effects and risks, including an increased risk of certain types of cancer, cardiovascular disease, and thromboembolic events. Therefore, their use should be carefully monitored and managed by a healthcare professional.

Soybean proteins are the proteins derived from soybeans, a legume native to East Asia. Soybeans contain approximately 40% protein by weight, making them a significant source of plant-based protein. The two major types of soy protein are:

1. Soy protein isolate (SPI): This is a highly refined protein that contains at least 90% protein by weight. It is made by removing carbohydrates and fiber from defatted soy flour, leaving behind a protein-rich powder. SPI is often used as an ingredient in various food products, including meat alternatives, energy bars, and beverages.
2. Soy protein concentrate (SPC): This type of soy protein contains approximately 70% protein by weight. It is made by removing some of the carbohydrates from defatted soy flour, leaving behind a higher concentration of proteins. SPC has applications in food and industrial uses, such as in textured vegetable protein (TVP) for meat alternatives, baked goods, and functional foods.

Soy proteins are considered high-quality proteins due to their complete amino acid profile, containing all nine essential amino acids necessary for human nutrition. They also have various health benefits, such as lowering cholesterol levels, improving bone health, and promoting muscle growth and maintenance. However, it is important to note that soy protein consumption should be balanced with other protein sources to ensure a diverse intake of nutrients.

Genistein is defined as a type of isoflavone, which is a plant-derived compound with estrogen-like properties. It is found in soybeans and other legumes. Genistein acts as a phytoestrogen, meaning it can bind to estrogen receptors and have both weak estrogenic and anti-estrogenic effects in the body.

In addition to its estrogenic activity, genistein has been found to have various biological activities, such as antioxidant, anti-inflammatory, and anticancer properties. It has been studied for its potential role in preventing or treating a variety of health conditions, including cancer, cardiovascular disease, osteoporosis, and menopausal symptoms. However, more research is needed to fully understand the potential benefits and risks of genistein supplementation.

... is a compound that can exist in two mirror-image forms known as enantiomers: (S)-equol and (R)-equol. (S)-equol is ... Relative to (S)-equol, (R)-equol is less potent and binds to ERα (Ki = 50 nM) with 3.5-fold selectivity over ERβ. (S)-Equol has ... S)-Equol was first isolated from horse urine in 1932, and the name was suggested by this equine connection. Since then, equol ... Equol can, for instance, lead to an increase in telomere length. As an antioxidant, equol can decrease the aging process by ...
Equol. Alpha hydroxy acids (AHAs) and beta hydroxy acids or other chemical peels. Peptides, such as acetyl hexapeptide-3 ( ...
Equol Philenoptera laxiflora (syn. Lonchocarpus laxiflorus) contains two isoflavanes: lonchocarpane and laxiflorane. ...
Equol Frankenfeld, C. L. (2011). "O-Desmethylangolensin: The Importance of Equol's Lesser Known Cousin to Human Health". ...
S)-Equol Liquiritigenin Menerba Sail, Vibhavari; Hadden, M. Kyle (2012-01-01), Desai, Manoj C. (ed.), Chapter Eighteen - Notch ... and Equol on the Growth of Tamoxifen-Resistant T47D/PKCα". Nutrition and Cancer. 58 (2): 222-9. doi:10.1080/01635580701328545. ...
Equol Glycitein Isoflavonoid Phytochemical Rotenoids "Soy isoflavones". Micronutrient Information Center, Linus Pauling ...
... produces equol and 5-hydroxy equol. In 2018, the genus Asaccharobacter was transferred into the genus ...
The major product of daidzein microbial metabolism is equol. Only 33% of Western Europeans have a microbiome that produces ... equol, compared to 50-55% of Asians. Soy isoflavones-polyphenolic compounds that are also produced by other legumes like ...
... is an equol-producing bacterium from the genus of Slackia which has been isolated from human faeces from ... nov., a human intestinal bacterium capable of producing equol". International Journal of Systematic and Evolutionary ...
Equol can occur as different isomers: R-equol, S-equol and RS-equol. Each of these forms has different characteristics, ... The active substance in Timeblock Skin Care is equol. The topical effect of equol as an anti-aging and skin health improving ... As an antioxidative operating substance, equol can decrease the aging process by reducing ROS events. Additionally, the ... Lephart, Edwin D. (2016). "Skin aging and oxidative stress: Equol's anti-aging effects via biochemical and molecular mechanisms ...
nov., an equol non-producing bacterium isolated from human faeces". International Journal of Systematic and Evolutionary ...
"Stinky tofu as a rich source of bioavailable S-equol in Asian diets". ResearchGate. 13 April 2013. "Yongfeng chili sauce". cgi. ...
Jackson, Richard L; Greiwe, Jeffrey S; Schwen, Richard J (2011). "Emerging evidence of the health benefits of S-equol, an ...
nov., an equol-producing bacterium isolated from human faeces, and emended description of the genus Eggerthella". International ... Adlercreutzia equolifaciens is a equol-producing bacterium from the genus of Adlercreutzia which has been isolated from human ...
... such as equol). Daidzein Equol Flavonoid Genistein Glycitein Homoisoflavonoids, related molecules with a 16-carbon skeleton ...
Nov., an equol-producing bacterium isolated from human faeces, and emended description of the genus Eggerthella". International ...
Matthies, A; Loh, G; Blaut, M; Braune, A (January 2012). "Daidzein and genistein are converted to equol and 5-hydroxy-equol by ...
S-Equol ((S)-4',7-isoflavandiol) - phytoestrogen; 13-fold selectivity for ERβ over ERα WAY-166818 WAY-200070 WAY-214156 ...
... equol, genistein, miroestrol, many others Selective estrogen receptor modulator Nonsteroidal antiandrogen Hermkens PH, Kamp S, ...
Equol Estradiol Ethynylestradiol Fulvestrant (ICI-182780)) G-1 Genistein GPER-L1 GPER-L2 Hydroxytyrosol Kepone LNS8801 Niacin ...
The molecular formula C15H14O3 (molar mass : 242.26 g/mol, exact mass: 242.094294) may refer to: Equol, an isoflavandiol ...
Equol is a compound that can exist in two mirror-image forms known as enantiomers: (S)-equol and (R)-equol. (S)-equol is ... Relative to (S)-equol, (R)-equol is less potent and binds to ERα (Ki = 50 nM) with 3.5-fold selectivity over ERβ. (S)-Equol has ... S)-Equol was first isolated from horse urine in 1932, and the name was suggested by this equine connection. Since then, equol ... Equol can, for instance, lead to an increase in telomere length. As an antioxidant, equol can decrease the aging process by ...
Testing Status of Equol M050041. Testing Status of Equol M050041. CASRN: 531-95-3. Formula: C15-H14-O3. Synonyms/Common Names. ...
... equol exists in two enantiomeric forms, R-(+) equol and S-(−) equol, and the latter is the natural diastereoisomer produced by ... equol producers, and those who cannot convert daidzein to equol are designated equol non-producers. There are currently no ... Results Equol non-producers comprised 67·9% of the overweight or obese subjects. The ratio of equol non-producers in this ... Placebo or natural S-equol tablets containing 10 mg S-equol were orally ingested each day for 12 weeks. A total of 54 Japanese ...
You have to enable JavaScript in your browsers settings in order to use the eReader.. Or try downloading the content offline. DOWNLOAD ...
EQUOL, (+/-)- (UNII: 2RZ8A7D0E8) (EQUOL, (+/-)- - UNII:2RZ8A7D0E8) EQUOL, (+/-)-. 6 [hp_X] in 1 mL. ... Label: APPETITE CONTROL (acetyl coenzyme a, adenosinum triphosphoricum dinatrum, adrenal cortex (suis), bacopa speciosa, equol ... acetyl coenzyme a, adenosinum triphosphoricum dinatrum, adrenal cortex (suis), bacopa speciosa, equol, gambogia, oxytocin ... APPETITE CONTROL (acetyl coenzyme a, adenosinum triphosphoricum dinatrum, adrenal cortex (suis), bacopa speciosa, equol, ...
This analysis demonstrates that the highly conserved equol gene cluster is taxonomically restricted to the Eggerthellaceae ... Equol Production Gene Cluster Organization. A diagram showing the organization of the detected equol production gene clusters ... Keywords: Eggerthellaceae; Equol; Equol-producing bacteria; Horizontal gene transfer; Human gut; Isoflavone. ... Taxonomic distribution and evolutionary analysis of the equol biosynthesis gene cluster Keith Dufault-Thompson 1 , Brantley ...
Equol (EQ) is a prominent microbial metabolite of the soy isoflavone, daidzein, with estrogen-like properties. The major soy ... Equol does not interact with genistein on estrogen-dependent breast tumor growth Huaxin Song 1 , Jennifer R Hughes 2 , Russell ... Equol does not interact with genistein on estrogen-dependent breast tumor growth Huaxin Song et al. Food Chem Toxicol. 2020 Feb ... A Systematic Review of the Effects of Equol (Soy Metabolite) on Breast Cancer. Hod R, Maniam S, Mohd Nor NH. Hod R, et al. ...
URXEQU - Equol (ng/mL). Variable Name: URXEQU. SAS Label: Equol (ng/mL). English Text: Equol (ng/mL). Target: Both males and ... URDEQULC - Equol comment code. Variable Name: URDEQULC. SAS Label: Equol comment code. English Text: Equol comment code. Target ... equol, O-desmethylangolensin, enterodiol, and enterolactone. Human urine samples are processed using enzymatic deconjugation of ...
URXEQU - Equol (ng/mL). Variable Name: URXEQU SAS Label: Equol (ng/mL). English Text: Equol (ng/mL). Target: Both males and ... URDEQULC - Equol comment code. Variable Name: URDEQULC. SAS Label: Equol comment code. English Text: Equol comment code. Target ... equol, O-desmethylangolensin, enterodiol, and enterolactone. Human urine samples are processed using enzymatic deconjugation of ...
Genetic Toxicity Evaluation of Equol in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A90698 Summary Data. * G06 - ... Equol (531-95-3). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program ... An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Equol (531-95-3). Bacterial Mutagenicity ... Equol (531-95-3). DOI: https://doi.org/10.22427/NTP-DATA-DTXSID0022309 ...
CDCs National Exposure Report is a series of ongoing assessments of the U.S. populations exposure to environmental chemicals using biomonitoring.
Clinically shown to help reduce hot flashes and menopausal muscle aches with plant-derived S-equol.† Find out how EQUELLE can ... S-equol has unique binding properties.5. S-equol is structurally similar to estrogen allowing it to mimic some estrogenic ... A natural S-equol supplement alleviates hot flushes and other menopausal symptoms in equol nonproducing postmenopausal Japanese ... Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their ...
Equol: anticancer component derived from intestinal daizdein. An isoflavone derivative that has aroused much interest is equol ... It has been observed that a certain type of intestinal microbiota is capable of producing equol from isoflavone daizdein. This ... investigations aimed at finding probiotics that perform this process of transforming isoflavones into derivatives such as equol ...
Soya - equol and anthocyanins.. *Tomatoes - lycopene.. People should be cautious about using concentrated versions of ...
Genistein and equol were applied for two, three or eight weeks. Genistein could accelerate the mineralization of the cortical ... In our second part we examined the effect of a two, three or eight week administration of Genistein and Equol. The control ... The substitution of genistein and equol could tend to slow the continuous decrease of the BMD (bone mineral density) of the ... The effect of Genistein and Equol combined with vibration therapy on bone parameters during the bone healing of an ...
The purpose of this study was to investigate the effects of equol, a plant and intestinal flora derived isoflavonoid molecule ... Equol at 0.3 or 1.2% in qPCR experiments using a human skin barrier model examined ECM gene expression. Equol, 5α-DHT, and 17β ... in addition to equol) to determine whether equol may play important and beneficial roles in the extracellular matrix (ECM). ... 5α-DHT significantly decreased cell viability that was blocked by equol. FACS analysis showed equol and 17β -estradiol ...
Soy intake may slash heart disease risk by 12%, but only for equol producers 09-Feb-2016. By Stephen Daniells ... Soy supplements may reduce the risk of cardiovascular risk for people able to produce equol, a microbial-derived metabolite of ... the isoflavone daidzein, but equol supplements themselves may not have the same effects, says a new study. ...
... determine if non-equol producers will respond to dietary equol physiologically similar to what is observed in equol producers. ... Equol as "Proof of Principle". One of the most abundant isoflavones in soy, daidzein, is differentially metabolized to equol ... In several studies, equol and O-desmethylangolensin have been shown to bind to human estrogen receptors ?a and ß with a greater ... Equol has been found to inhibit the growth of benign and malignant prostate epithelial cells in vitro at concentrations that ...
Equol as "Proof of Principle". One of the most abundant isoflavones in soy, daidzein, is differentially metabolized to equol ... Finally, it will be important to determine if non-equol producers will respond to dietary equol physiologically similar to what ... In several studies, equol and O-desmethylangolensin have been shown to bind to human estrogen receptors "a and ß with a greater ... Equol has been found to inhibit the growth of benign and malignant prostate epithelial cells in vitro at concentrations that ...
Production of outdoor and equol enriched eggs for the benefit of human health. Tosar, V. , Rousseau, G. , Larondelle, Y. & ... Red clover-rich grassland increases equol concentration in eggs from free-range laying hens. Tosar, V. , Rousseau, G. , ... Froidmont, E. (2018). Production of outdoor and equol enriched eggs for the benefit of human health. Poster in: XVth European ... Decruyenaere, V. , Beckers, Y. , Larondelle, Y. & Froidmont, E. (2021). Red clover-rich grassland increases equol concentration ...
Equol 4-O-glucuronide. 0. Equol 7-O-glucuronide. 0. Formononetin 7-(2-p-hydroxybenzoylglucoside). 0. ...
Estrone and equol persisted along the waste disposal route. Following application of lagoon slurry to agricultural soils, all ... Excreta also contained phytoestrogens indicative of a soy-based diet, particularly, daidzein, genistein, and equol. During ... However, analytes including estrone, androstenedione, progesterone, and equol remained detectable in soil at 2 months ... Equol/chemistry; Estrogens/chemistry*; Estrone/chemistry; Feces/chemistry; Genistein/chemistry; Hormones/chemistry*; ...
The effect of soy consumption on the urinary 2:16-hydroxyestrone ratio in postmenopausal women depends on equol production ... Some research suggests that those who produce equol may particularly benefit from eating soyfoods. ... of Asian populations have gut bacteria that are able to produce a compound called equol from the soy isoflavone daidzein. ...
Your session will timeout in 10 minutes. You will be redirected to the HOME page after session timeout. Please click the button to continue session from the same page. minute. You will be redirected to the HOME page after session timeout. Please click the button to continue session from the same page. ...
2008). Soy food consumption does not lower LDL cholesterol in either equol or nonequol producers.. http://www.ncbi.nlm.nih.gov/ ...
Magee, P.J.; Allsopp, P.; Samaletdin, A.; Rowland, I.R. Daidzein, R-(+)equol and S-(−)equol inhibit the invasion of MDA-MB-231 ... These effects were observed after relatively high doses of equol (100 μM) and 4-OHT (10 μM) [52]. In a similar experiment, ... The overlap of estrogen regulated genes was greater for genistein and equol, compared to the gene expression patterns of other ... In MCF-7 cells, equol and 4-hydroxy-tamoxifen (4-OHT), the active metabolite of tamoxifen, induced activation of caspase-9 and ...
  • Equol (4',7-isoflavandiol) is an isoflavandiol estrogen metabolized from daidzein, a type of isoflavone found in soybeans and other plant sources, by bacterial flora in the intestines. (wikipedia.org)
  • S)-equol is produced in humans and animals with the ability to metabolize the soy isoflavone daidzein, while (R)-equol can be chemically synthesized. (wikipedia.org)
  • Equol] is made from daidzein, a type of soy isoflavone, and is a component that helps keep women healthy and youthful. (arigatoujapan.com)
  • Our previous case-control study suggested that equol, a metabolite of isoflavone, has a preventive effect on prostate cancer. (nih.gov)
  • To examine the prostate cancer risk based on isoflavone intake and equol production, we carried out a phase II, randomized, double-blind, placebo-controlled trial of oral isoflavone (60 mg/day) for 12 months. (nih.gov)
  • Equol is an active metabolite of soy isoflavone . (bvsalud.org)
  • In addition to the amount of soy isoflavones consumed, the form and food source of isoflavones, timing of isoflavone exposure, estrogen receptor status of tumors, and equol-producer status and hormonal profile of individuals may modify the association between soy isoflavone intake and the risk of breast cancer. (go.jp)
  • Vegetarians have also been reported to be more capable of transforming daidzein into (S)-equol. (wikipedia.org)
  • Equol, a metabolite of daidzein, has been shown to inhibit bone loss in ovariectomized mice and rats. (geneticsmr.com)
  • Daidzein and the daidzein metabolite, equol, enhance adipocyte differentiation and PPARgamma transcriptional activity. (oregonstate.edu)
  • Since the insulin-sensitizing effects of thiazolidinediones, antidiabetic drugs, are mediated through activation of peroxisome proliferators-activated receptor gamma (PPARgamma), we examined the effects of daidzein and the daidzein metabolite, equol, on adipocyte differentiation and PPARgamma activation. (oregonstate.edu)
  • These data further support the recent findings that favorable effects of dietary soy isoflavones may be attributable to daidzein and its metabolite equol. (oregonstate.edu)
  • A 2015 study published in Metabolism found women with and without metabolic syndrome who produced equol, a gut bacteria metabolite resulting from soy consumption, enjoyed cardiovascular benefits from consuming soy nuts. (naturalproductsinsider.com)
  • Since then, equol has been found in the urine or plasma of many other animal species, although these animals have significant differences in their ability to metabolize daidzein into equol. (wikipedia.org)
  • Equol is formed exclusively by bacteria in the gut, but only about a third of all Caucasians possess the necessary gut microflora capable of converting daidzein into equol. (nutraingredients.com)
  • The bioavailability of the soy isoflavones genistein and daidzein, and metabolism of the latter to form equol, is higher after soymilk consumption than soy germ, says a new study. (nutraingredients.com)
  • The test principle utilizes high performance liquid chromatography-atmospheric pressure photoionization-tandem mass spectrometry (HPLC-APPI-MS/MS) for the quantitative detection of genistein, daidzein, equol, O-desmethylangolensin, enterodiol, and enterolactone. (cdc.gov)
  • daidzein (which is transformed into equol ), genistein , glycytein, biochanin A and formonometin . (botanical-online.com)
  • Several studies indicate that only 25 to 30 percent of the adult populations of Western countries produce (S)-equol after eating soy foods containing isoflavones, while 50 to 60 percent of adults from Japan, Korea, and China are equol-producers. (wikipedia.org)
  • By classifying the individuals as poor, moderate, and strong equol producers, the researchers observed that higher counts of the bacteria Clostridium coccoides-Eubacterium rectale ​ were associated with less equol, while increased sulfate-reducing bacteria counts was associated with increased equol production. (nutraingredients.com)
  • This shows "the potential of faecal incubations to identify equol producers without dietary intervention," ​ they said. (nutraingredients.com)
  • Their median age was 66.0 years, and the numbers of equol producers and non-producers were 76 (48%) and 82 (52%), respectively. (nih.gov)
  • Equol producers were defined as those with a urinary equol concentration of 1.0 µM or more. (bvsalud.org)
  • Of the 1,345 women , 378 (28.1%) were equol producers. (bvsalud.org)
  • 1 However, non-equol producers experienced no improvement. (naturalproductsinsider.com)
  • As a phytoestrogen , equol has the potential to prevent metabolic disorders such as hyperglycemia , hyperlipidemia , and obesity . (bvsalud.org)
  • The chemical formula of a human estrogenic hormone (estradiol) and a phytoestrogen (equol) is observed in the image. (botanical-online.com)
  • The researchers noted a good correlation between the urinary excretion profiles and equol production and the subjects' phenotypes based on the daidzein metabolism by faecal cultures. (nutraingredients.com)
  • Feeding experiments with different food constituents and monitoring the urinary excretion of equol revealed that soya food yields more than 0·1 mg urinary equol/g flour ingested. (endocrinology-journals.org)
  • Both equol and daidzein were characterized as monoglucuronide conjugates in human urine and the concentration of urinary equol exceeded the concentrations of the classical oestrogens by 100- to 1000-fold after ingestion of a single meal containing soya protein. (endocrinology-journals.org)
  • Subgroup analysis did not support an effect of equol phenotype on bone density. (nih.gov)
  • Equol is a compound that can exist in two mirror-image forms known as enantiomers: (S)-equol and (R)-equol. (wikipedia.org)
  • Impact of perinatal exposure to equol enantiomers on reproductive development in rodents. (bvsalud.org)
  • Association between equol production and metabolic syndrome in Japanese women in their 50s-60s. (bvsalud.org)
  • This study aimed to determine the association between equol production and metabolic syndrome (METS) in postmenopausal women . (bvsalud.org)
  • The preferential binding of (S)-equol to ERβ vs. ERα and in comparison to that of estradiol suggests the molecule may share some of the characteristics of a selective estrogen receptor modulator (SERM). (wikipedia.org)
  • S)-Equol is a very stable molecule that essentially remains unchanged when digested, and this lack of further metabolism explains its very quick absorption and high bioavailability. (wikipedia.org)
  • Equol is just a molecule. (baldtruthtalk.com)
  • Only about 30-50% of people have intestinal bacteria that make equol. (wikipedia.org)
  • To produce (S)-equol after soy consumption, humans must have certain strains of bacteria living within their intestines. (wikipedia.org)
  • Twenty-one different strains of intestinal bacteria cultured from humans have been shown to have the ability to transform daidzein into (S)-equol or a related intermediate compound. (wikipedia.org)
  • Julong 732 can also produce (S)-equol.Bifidobacteria: Genomics and Molecular Aspects Some equol producing bacteria, as implied by their nomenclature, are Adlercreutzia equolifaciens, Slackia equolifaciens and Slackia isoflavoniconvertens. (wikipedia.org)
  • While endogenous estrogenic hormones such as estradiol are steroids, equol is a nonsteroidal estrogen. (wikipedia.org)
  • The molecular and physical structure of (S)-equol is similar to that of the hormone estradiol. (wikipedia.org)
  • When (S)-equol is consumed, it is rapidly absorbed and achieves a Tmax (rate of peak plasma concentration) in two to three hours. (wikipedia.org)
  • The (S)-equol concentration in each test subject's urine is determined on day four. (wikipedia.org)
  • The serum concentration of Amitriptyline can be increased when it is combined with Equol. (drugbank.com)
  • The investigational S-equol nutritional supplement may be a viable agent to alleviate certain menopause symptoms, such as hot flashes, according to a new peer-reviewed article in the March Journal of Women's Health. (news-medical.net)
  • In 1980, scientists reported the discovery of equol in humans. (wikipedia.org)
  • In C3H10T1/2 cells, both daidzein and equol at 1 micromol/L and higher significantly increased adipocyte differentiation and insulin-stimulated glucose uptake. (oregonstate.edu)
  • Different equol concentrations significantly promoted the proliferation of osteoblasts after 48- and 72-h incubations. (geneticsmr.com)
  • Equol production was associated with a lower prevalence of METS among women aged 50 to 69 years. (bvsalud.org)
  • In this report, we approached a novel treatment strategy by combining two bioactive dietary constituents (resveratrol and equol) to determine their effect on mitochondrial function. (lonza.com)
  • S)-Equol preferentially binds estrogen receptor beta. (wikipedia.org)
  • S)-Equol has about 2% of estradiol's binding affinity for human estrogen receptor alpha (ERα) and 20% of estradiol's binding affinity for human estrogen receptor beta (ERβ). (wikipedia.org)
  • Moreover, an increased dietary intake of polyunsaturated fatty acids (PUFAs) was associated with increased equol production. (nutraingredients.com)
  • It is a supplement containing 10 mg of [S-equol], which has the power to lead to liveliness, beauty, and heartbeat, per daily intake guideline. (arigatoujapan.com)
  • The proportion of women who had METS (6.6% vs 10.9%) was significantly lower in the equol -producing group than in the nonproducing group. (bvsalud.org)
  • The dietary origin of the weak oestrogen equol (7-hydroxy-3-(4′-hydroxyphenyl)-chroman) present in human urine has been investigated using gas chromatography-mass spectrometry. (endocrinology-journals.org)
  • Therefore, we investigated the effect of equol on the proliferation and differentiation of rat primary osteoblasts and explored the involved mechanisms. (geneticsmr.com)
  • Relative to (S)-equol, (R)-equol is less potent and binds to ERα (Ki = 50 nM) with 3.5-fold selectivity over ERβ. (wikipedia.org)
  • But roughly one-third of all people who eat soy can metabolize diadzein into equol, which is among the most potent plant estrogens known. (holisticprimarycare.net)
  • Seaweed and dairy consumption can enhance the production of equol. (wikipedia.org)
  • The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Equol. (drugbank.com)
  • The present study investigated S-equol (SE) as a potential therapeutic for HAND by modulating the gut microbiome. (sc.edu)
  • However, whether or not equol influences the formation of bone has not yet been investigated. (geneticsmr.com)
  • The association between equol production and METS was estimated by logistic regression analysis , with adjustments for age, exercise, physical activity, and fast walking . (bvsalud.org)
  • The percent fractional elimination of (S)-equol in urine after oral administration is high and in some adults can reach close to 100 percent. (wikipedia.org)
  • NMN Equol 9000 contains 75 mg of pomegranate extract powder in 2 tablets. (rajeunir.info)
  • So, let's talk about the ingredients contained in NMN Equol 9000 that are said to be good for beauty and health. (rajeunir.info)
  • Equol has been found to act as an agonist of the GPER (GPR30). (wikipedia.org)
  • The ability of (S)-equol to play a role in the treatment of estrogen- or androgen-mediated diseases or disorders was first proposed in 1984. (wikipedia.org)
  • Equol has been used in trials studying the treatment of Breast Cancer. (drugbank.com)
  • The ability of a person to produce (S)-equol is determined by testing people who have not taken any antibiotics for at least a month. (wikipedia.org)
  • We want more people to know about NMN Equol 9000! (rajeunir.info)
  • I've only posted science saying that equol is probably the safest alternative to fin. (baldtruthtalk.com)
  • Equol may decrease the anticoagulant activities of Abciximab. (drugbank.com)
  • Aceclofenac may increase the thrombogenic activities of Equol. (drugbank.com)
  • Equol may decrease the anticoagulant activities of Acenocoumarol. (drugbank.com)
  • Equol may increase the thrombogenic activities of Adalimumab. (drugbank.com)
  • Equol may increase the thrombogenic activities of Aducanumab. (drugbank.com)
  • Equol may increase the thrombogenic activities of Alirocumab. (drugbank.com)
  • Equol may decrease the anticoagulant activities of Alteplase. (drugbank.com)
  • Taking into account that the biological activities of resveratrol and equol has been observed in a wide range of biological processes, they were selected to examine whether combining them would be more effective to modulate mitochondrial function. (lonza.com)
  • Furthermore, daidzein and equol up-regulated PPARgamma-mediated transcriptional activity, and daidzein restored the PPARgamma antagonist-induced inhibition of aP2 and GLUT4 mRNA levels. (oregonstate.edu)