Rare, chronic, papulo-vesicular disease characterized by an intensely pruritic eruption consisting of various combinations of symmetrical, erythematous, papular, vesicular, or bullous lesions. The disease is strongly associated with the presence of HLA-B8 and HLA-DR3 antigens. A variety of different autoantibodies has been detected in small numbers in patients with dermatitis herpetiformis.
Prolamins in the endosperm of SEEDS from the Triticeae tribe which includes species of WHEAT; BARLEY; and RYE.
A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.
A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
The middle portion of the SMALL INTESTINE, between DUODENUM and ILEUM. It represents about 2/5 of the remaining portion of the small intestine below duodenum.
Skin diseases characterized by local or general distributions of blisters. They are classified according to the site and mode of blister formation. Lesions can appear spontaneously or be precipitated by infection, trauma, or sunlight. Etiologies include immunologic and genetic factors. (From Scientific American Medicine, 1990)
Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.
A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.
A scleroprotein fibril consisting mostly of type III collagen. Reticulin fibrils are extremely thin, with a diameter of between 0.5 and 2 um. They are involved in maintaining the structural integrity in a variety of organs.
Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.
Antibacterial, potentially toxic, used to treat certain skin diseases.
Any inflammation of the skin.
A plant species of the family POACEAE that is widely cultivated for its edible seeds.
A diet which is devoid of GLUTENS from WHEAT; BARLEY; RYE; and other wheat-related varieties. The diet is designed to reduce exposure to those proteins in gluten that trigger INFLAMMATION of the small intestinal mucosa in patients with CELIAC DISEASE.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
By adjusting the quantity and quality of food intake to improve health status of an individual. This term does not include the methods of food intake (NUTRITIONAL SUPPORT).
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.
A form of fluorescent antibody technique utilizing a fluorochrome conjugated to an antibody, which is added directly to a tissue or cell suspension for the detection of a specific antigen. (Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
Pathological processes in any segment of the INTESTINE from DUODENUM to RECTUM.

Coeliac disease and dermatitis herpetiformis: further studies of their relationship. (1/137)

Using diagnostic criteria which are currently accepted as most reliable we have found that 19% (9/47) of patients with dermatitis herpetiformis (DH) have no evidence of coeliac disease. The incidence of HL-A8 in the DH patients was 78%, which is considerably greater than that in healthy controls and no different from that reported in coeliac disease. Furthermore, the incidence of HL-A8 was just as much increased in those DH patients without evidence of coeliac disease suggesting that HL-A8 is associated with DH per se--that is, regardless of its association with coeliac disease.  (+info)

The widening spectrum of celiac disease. (2/137)

Celiac disease is a permanent intolerance to ingested gluten that results in immunologically mediated inflammatory damage to the small-intestinal mucosa. Celiac disease is associated with both human leukocyte antigen (HLA) and non-HLA genes and with other immune disorders, notably juvenile diabetes and thyroid disease. The classic sprue syndrome of steatorrhea and malnutrition coupled with multiple deficiency states may be less common than more subtle and often monosymptomatic presentations of the disease. Diverse problems such as dental anomalies, short stature, osteopenic bone disease, lactose intolerance, infertility, and nonspecific abdominal pain among many others may be the only manifestations of celiac disease. The rate at which celiac disease is diagnosed depends on the level of suspicion for the disease. Although diagnosis relies on intestinal biopsy findings, serologic tests are useful as screening tools and as an adjunct to diagnosis. The treatment of celiac disease is lifelong avoidance of dietary gluten. Gluten-free diets are now readily achievable with appropriate professional instruction and community support. Both benign and malignant complications of celiac disease occur but these can often be avoided by early diagnosis and compliance with a gluten-free diet.  (+info)

Patchiness and duodenal-jejunal variation of the mucosal abnormality in coeliac disease and dermatitis herpetiformis. (3/137)

The incidence and degree of patchiness of mucosal abnormality in both coeliac disease (CD) and dermatitis herpetiformis (DH) is documented. As judged by both stereomicroscopy and subjective histology, patchiness occurred frequently in both CDand DH patients. In most cases the difference of abnormality was of only one grade, but in approximately 25% as assessed by stereomicroscopy and 10% as assessed by histology the difference was of two or more grades. In control subjects with normal small bowel mucosa the variation of the mucosal appearance between the duodenum and proximal jejunum was studied. Contrary to popular belief, no significant difference of villous and crypt measurements or of apparent villous "bridging" and "branching" between these two sites was found, if only well-orientated sections were studied. The stereomicroscopic appearances were also similar at these two sites, although villi tended to be broader in the duodenal biopsies. The duodenal-jejunal variation was also studied in CD and DH patients and although by both stereomicroscopy and subjective histology the appearances were similar in most patients, in approximately 33% the duodenal abnormality was the most severe and, surprisingly, the jejunal abnormality was more severe in approximately 15%. It is concluded that multiple, precisely located biopsies of both the duodenum and proximal jejunum are invaluable in the investigation of small bowel disease and in assessing response to treatment.  (+info)

Enhanced expression of human metalloelastase (MMP-12) in cutaneous granulomas and macrophage migration. (4/137)

Accumulation of inflammatory cells such as macrophages may lead to degeneration of connective tissue matrix in various skin diseases. Macrophage metalloelastase, is a matrix metalloproteinase (MMP-12) capable of degrading elastin as well as various basement membrane components. To investigate the role of human macrophage metalloelastase in skin, we assessed by in situ hybridization and immunohistochemistry 66 specimens representing skin diseases characterized either by changes in elastic fibers or by pronounced infiltrations of extravasating and migrating macrophages. CD68 immunostaining was performed to identify the human macrophage metalloelastase-positive cells and Weigert's Resorcin-Fuchsin staining to reveal the status of elastic fibers. We found abundant expression of human macrophage metalloelastase mRNA in macrophages in areas devoid of normal elastic fibers in granulomatous skin diseases sarcoidosis, necrobiosis lipoidica diabeticorum, and granuloma annulare. Positive cells for human macrophage metalloelastase protein could be detected in the same regions as well as positive immunostaining for urokinase plasminogen activator. Of the other matrix metalloproteinases capable of degrading elastin, 92 kDa gelatinase colocalized with human macrophage metalloelastase, while 72 kDa gelatinase was produced by surrounding fibroblast-like cells. Furthermore, human macrophage metalloelastase was expressed by macrophages in areas with disrupted basement membrane, as assessed by type IV collagen staining, in pityriasis lichenoides and dermatitis herpetiformis. Specimens of anetoderma, acrodermatitis chronica atrophicans and pseudoxanthoma elasticum showed no signal for human macrophage metalloelastase. Matrilysin was not detected in any of the samples investigated. Our study suggests that human macrophage metalloelastase may contribute to elastin degradation occurring in granulomatous skin diseases and may aid macrophage migration through the epidermal and vascular basement membranes in inflammatory disorders.  (+info)

Antibodies to tissue transglutaminase as serologic markers in patients with dermatitis herpetiformis. (5/137)

Dermatitis herpetiformis is a gluten-sensitive disease with a symmetrically distributed blistering over extensor surfaces. The association with celiac disease is further supported by the high rate of immunoglobulin A autoantibodies to endomysium in patients with dermatitis herpetiformis, which are highly specific and sensitive indicators of celiac disease. Therefore, we determined immunoglobulin A antibodies to tissue transglutaminase, the recently discovered endomysial autoantigen in celiac disease, in patients with dermatitis herpetiformis and controls. Sera of 61 patients with dermatitis herpetiformis, as characterized by granular immunoglobulin A deposits in the subepidermal basement membrane and known endomysial antibody titers (determined by indirect immunofluorescence) as well as 84 control sera of patients with dermal or intestinal diseases unrelated to dermatitis herpetiformis, were analyzed for circulating immunoglobulin A antibodies to tissue transglutaminase by enzyme-linked immunosorbent assay. Immunoglobulin A anti-tissue transglutaminase titers in patients with dermatitis herpetiformis were significantly elevated above the controls. Furthermore, the immunoglobulin A anti-tTG titers showed a positive correlation with semiquantitative endomysial antibody data. Compared with endomysial antibodies, determination of immunoglobulin A anti-tissue transglutaminase reached a specificity and sensitivity of 97.6% and 89.1%. Patients with dermatitis herpetiformis have elevated immunoglobulin A autoantibodies to tissue transglutaminase, confirming its pathogenic relation with celiac disease and further supporting the usefulness of this novel assay for screening and therapy control.  (+info)

Concordance of dermatitis herpetiformis and celiac disease in monozygous twins. (6/137)

Celiac disease can be defined as the classical manifestation of gluten sensitivity, which primarily affects the small intestine. Gluten sensitivity has also a skin manifestation, i.e., dermatitis herpetiformis. Both diseases have a strong genetic association with HLA DQ on chromosome 6. In this study we tried to estimate how much different clinical expressions of gluten sensitivity are determined by genetic factors, and hence how feasible they are for genetic mapping; therefore, we studied all six monozygous twin pairs found among 1292 prospectively collected patients of dermatitis herpetiformis in Finland. Three of the six twin pairs were concordant for dermatitis herpetiformis and for simultaneous enteropathy, celiac disease. Two other twin pairs were partially discordant, one of each pair had dermatitis herpetiformis and celiac disease, whereas the other had solely the gut manifestation of gluten sensitivity, i.e., celiac disease. Only one pair was found to be discordant for gluten sensitivity. All the pairs had typical risk alleles for gluten sensitivity, i.e., either HLA DQ2 or DQ8. These results demonstrate that the genetic component in gluten sensitivity as broadly defined is very strong (5/6 concordant). Genetically identical individuals can have clearly distinguished phenotypes, either dermatitis herpetiformis or celiac disease, suggesting that environmental factors determine the exact phenotype of this multifactorial disease. These findings are of importance in genetic linkage analyses, which focus to only certain phenotypic properties of a complex trait.  (+info)

Parallel expression of macrophage metalloelastase (MMP-12) in duodenal and skin lesions of patients with dermatitis herpetiformis. (7/137)

BACKGROUND: Dermatitis herpetiformis (DH) is a specific dermatological manifestation of coeliac disease and 80% of DH patients have gluten sensitive enteropathy manifested by crypt hyperplasia and villous atrophy. Matrix degradation mediated by collagenase 1 (MMP-1) and stromelysin 1 (MMP-3) has previously been implicated in the pathobiology of coeliac intestine and cutaneous DH blisters. AIMS: To study expression of stromelysin 2, metalloelastase, collagenase 3, and matrilysin in the intestine and skin of DH patients. METHODS: In situ hybridisation using 35S labelled cRNA probes was performed on duodenal biopsies of 15 DH patients, three samples each of control duodenal or jejunal mucosa, fetal ileal explants, lesional DH skin, and 19 serial biopsies of experimental DH blisters. Immunostaining was used to examine type IV collagen, macrophages (CD68), and 92 kDa gelatinase (MMP-9) in the specimens. RESULTS: Metalloelastase (MMP-12) was abundantly expressed by subepithelial macrophages in both coeliac intestine and spontaneous and induced DH rash. It was also upregulated in the experimental model of coeliac disease (staphylococcal endotoxin B stimulated fetal explants). The only other MMP detected was MMP-9 which did not colocalise with MMP-12. CONCLUSIONS: Upregulation of metalloelastase is associated with T cell mediated immune responses both in the intestine and skin. In addition to modulating macrophage migration, it may contribute to degradation of proteoglycans or basement membrane components in the subepithelial mucosa.  (+info)

Candidate gene regions and genetic heterogeneity in gluten sensitivity. (8/137)

BACKGROUND: Gluten sensitivity is a common multifactorial disorder, manifested in the small intestine or on the skin as typical coeliac disease or dermatitis herpetiformis, respectively. The only established genetic risk factor is HLA DQ2. AIMS: We tested genetic linkage of previously reported chromosomal loci 5q and 11q in Finnish families with gluten sensitivity. We also tested if genetic linkage to candidate loci on 5q, 11q, 2q33, and HLA DQ differed with respect to clinical manifestations or sex. SUBJECTS: We studied 102 Finnish families with affected sibpairs. For heterogeneity analysis, families were divided into subgroups according to sex and the presence of dermatitis herpetiformis, the skin manifestation of gluten sensitivity. METHODS: Non-parametric linkage between microsatellite markers and disease was tested. Linkage heterogeneity between subgroups was tested using the M test. The transmission/disequilibrium test and association analysis were performed. RESULTS: Evidence of linkage to 11q (MLS 1.37), but not to 5q, was found in the entire dataset of 102 families. Heterogeneity between subgroups was suggested: families with only the intestinal disease showed linkage mainly to 2q33 whereas families with dermatitis herpetiformis showed linkage to 11q and 5q, but not to 2q33. Linkage in all three non-HLA loci was strongest in families with predominantly male patients. HLA DQ2 conferred much stronger susceptibility to females than males. CONCLUSIONS: Independent evidence for the suggested genetic linkage between 11q and gluten sensitivity was obtained. The possible linkage heterogeneity suggests genetic differences between intestinal and skin manifestations, and the gender dependent effect of HLA DQ2.  (+info)

Dermatitis herpetiformis (DH) is a chronic, autoimmune blistering skin disorder that is characterized by the presence of symmetrical, pruritic (itchy), papulo-vesicular (papules and small fluid-filled blisters) eruptions on the extensor surfaces of the body, such as the elbows, knees, buttocks, and shoulders. It is often associated with gluten sensitivity or celiac disease, a condition that causes an abnormal immune response to gluten, a protein found in wheat, barley, and rye.

The exact cause of DH is not fully understood, but it is believed to result from the interaction between genetic, environmental, and immunological factors. The disorder is characterized by the presence of IgA antibodies in the skin, which trigger an immune response that leads to the formation of the characteristic rash.

DH is typically treated with a gluten-free diet, which can help to control the symptoms and prevent complications such as malabsorption and nutritional deficiencies. Medications such as dapsone may also be used to control the itching and blistering associated with the disorder. In some cases, topical corticosteroids or other anti-inflammatory medications may be prescribed to help manage symptoms.

It is important to note that DH is a chronic condition that requires ongoing management and monitoring. People with DH should work closely with their healthcare provider to develop an appropriate treatment plan and monitor their progress over time.

"Gluten" is not strictly defined as a medical term, but it refers to a group of proteins found in certain grains, including wheat, barley, and rye. Gluten gives these grains their elasticity and helps them maintain their shape, making it possible to bake breads and other baked goods.

From a medical perspective, gluten is significant because some people have adverse reactions to it. The two main conditions related to gluten are celiac disease and non-celiac gluten sensitivity. In both cases, consuming gluten can lead to various symptoms such as gastrointestinal distress, fatigue, and skin rashes.

Celiac disease is an autoimmune disorder where the ingestion of gluten causes damage to the small intestine lining, impairing nutrient absorption. On the other hand, non-celiac gluten sensitivity does not involve an immune response or intestinal damage but can still cause uncomfortable symptoms in some individuals.

It is essential to understand that a gluten-free diet should be medically recommended and supervised by healthcare professionals for those diagnosed with celiac disease or non-celiac gluten sensitivity, as it may lead to nutritional deficiencies if not properly managed.

Celiac disease is a genetic autoimmune disorder in which the consumption of gluten, a protein found in wheat, barley, and rye, leads to damage in the small intestine. In people with celiac disease, their immune system reacts to gluten by attacking the lining of the small intestine, leading to inflammation and destruction of the villi - finger-like projections that help absorb nutrients from food.

This damage can result in various symptoms such as diarrhea, bloating, fatigue, anemia, and malnutrition. Over time, if left untreated, celiac disease can lead to serious health complications, including osteoporosis, infertility, neurological disorders, and even certain types of cancer.

The only treatment for celiac disease is a strict gluten-free diet, which involves avoiding all foods, beverages, and products that contain gluten. With proper management, individuals with celiac disease can lead healthy lives and prevent further intestinal damage and related health complications.

Dapsone is a medication that belongs to a class of drugs called sulfones. It is primarily used to treat bacterial skin infections such as leprosy and dermatitis herpetiformis (a skin condition associated with coeliac disease). Dapsone works by killing the bacteria responsible for these infections.

In addition, dapsone has anti-inflammatory properties and is sometimes used off-label to manage inflammatory conditions such as vasculitis, bullous pemphigoid, and chronic urticaria. It is available in oral tablet form and topical cream or gel form.

Like all medications, dapsone can cause side effects, which may include nausea, loss of appetite, and headache. More serious side effects, such as methemoglobinemia (a blood disorder that affects the body's ability to transport oxygen), peripheral neuropathy (nerve damage that causes pain, numbness, or weakness in the hands and feet), and liver damage, can occur but are less common.

It is important for patients taking dapsone to be monitored by a healthcare provider to ensure safe and effective use of the medication.

The jejunum is the middle section of the small intestine, located between the duodenum and the ileum. It is responsible for the majority of nutrient absorption that occurs in the small intestine, particularly carbohydrates, proteins, and some fats. The jejunum is characterized by its smooth muscle structure, which allows it to contract and mix food with digestive enzymes and absorb nutrients through its extensive network of finger-like projections called villi.

The jejunum is also lined with microvilli, which further increase the surface area available for absorption. Additionally, the jejunum contains numerous lymphatic vessels called lacteals, which help to absorb fats and fat-soluble vitamins into the bloodstream. Overall, the jejunum plays a critical role in the digestion and absorption of nutrients from food.

Vesiculobullous skin diseases are a group of disorders characterized by the formation of blisters (vesicles) and bullae (larger blisters) on the skin. These blisters form when there is a separation between the epidermis (outer layer of the skin) and the dermis (layer beneath the epidermis) due to damage in the area where they join, known as the dermo-epidermal junction.

There are several types of vesiculobullous diseases, each with its own specific causes and symptoms. Some of the most common types include:

1. Pemphigus vulgaris: an autoimmune disorder where the immune system mistakenly attacks proteins that help to hold the skin together, causing blisters to form.
2. Bullous pemphigoid: another autoimmune disorder, but in this case, the immune system attacks a different set of proteins, leading to large blisters and inflammation.
3. Dermatitis herpetiformis: a skin condition associated with celiac disease, where gluten ingestion triggers an immune response that leads to the formation of itchy blisters.
4. Pemphigoid gestationis: a rare autoimmune disorder that occurs during pregnancy and causes blisters on the abdomen and other parts of the body.
5. Epidermolysis bullosa: a group of inherited disorders where there is a fragile skin structure, leading to blistering and wound formation after minor trauma or friction.

Treatment for vesiculobullous diseases depends on the specific diagnosis and may include topical or systemic medications, such as corticosteroids, immunosuppressants, or antibiotics, as well as wound care and prevention of infection.

Immunoglobulin A (IgA) is a type of antibody that plays a crucial role in the immune function of the human body. It is primarily found in external secretions, such as saliva, tears, breast milk, and sweat, as well as in mucous membranes lining the respiratory and gastrointestinal tracts. IgA exists in two forms: a monomeric form found in serum and a polymeric form found in secretions.

The primary function of IgA is to provide immune protection at mucosal surfaces, which are exposed to various environmental antigens, such as bacteria, viruses, parasites, and allergens. By doing so, it helps prevent the entry and colonization of pathogens into the body, reducing the risk of infections and inflammation.

IgA functions by binding to antigens present on the surface of pathogens or allergens, forming immune complexes that can neutralize their activity. These complexes are then transported across the epithelial cells lining mucosal surfaces and released into the lumen, where they prevent the adherence and invasion of pathogens.

In summary, Immunoglobulin A (IgA) is a vital antibody that provides immune defense at mucosal surfaces by neutralizing and preventing the entry of harmful antigens into the body.

Atopic dermatitis is a chronic, inflammatory skin condition that is commonly known as eczema. It is characterized by dry, itchy, and scaly patches on the skin that can become red, swollen, and cracked over time. The condition often affects the skin on the face, hands, feet, and behind the knees, and it can be triggered or worsened by exposure to certain allergens, irritants, stress, or changes in temperature and humidity. Atopic dermatitis is more common in people with a family history of allergies, such as asthma or hay fever, and it often begins in infancy or early childhood. The exact cause of atopic dermatitis is not fully understood, but it is thought to involve a combination of genetic and environmental factors that affect the immune system and the skin's ability to maintain a healthy barrier function.

Reticulin is a type of protein fiber that forms part of the extracellular matrix in various connective tissues in the body. It is composed of collagenous and non-collagenous proteins, and it has a reticular or network-like structure when viewed under a microscope. In histology (the study of the microscopic structure of tissues), reticulin fibers are often stained to help identify certain types of cells or structures.

In particular, reticulin fibers are often found in close association with certain types of cells, such as hematopoietic stem cells and neurons. They provide structural support and help regulate the function of these cells. In addition, reticulin fibers play a role in the immune response, wound healing, and tissue repair.

Abnormal accumulations of reticulin fibers can be seen in various disease states, such as fibrosis (excessive scarring) and certain types of cancer. For example, increased reticulin fibers are often found in the liver in patients with cirrhosis, a condition characterized by extensive scarring and damage to the liver. Similarly, abnormal reticulin fiber deposition is seen in some forms of lymphoma, a type of cancer that affects the lymphatic system.

Transglutaminases are a family of enzymes that catalyze the post-translational modification of proteins by forming isopeptide bonds between the carboxamide group of peptide-bound glutamine residues and the ε-amino group of lysine residues. This process is known as transamidation or cross-linking. Transglutaminases play important roles in various biological processes, including cell signaling, differentiation, apoptosis, and tissue repair. There are several types of transglutaminases, such as tissue transglutaminase (TG2), factor XIII, and blood coagulation factor XIIIA. Abnormal activity or expression of these enzymes has been implicated in various diseases, such as celiac disease, neurodegenerative disorders, and cancer.

Sulfapyridine is an antibiotic drug that belongs to the class of medications known as sulfonamides or "sulfa drugs." It is used to treat various bacterial infections by interfering with the bacteria's ability to synthesize essential proteins. Sulfapyridine may be used to treat a variety of infections, including urinary tract infections, bronchitis, and traveler's diarrhea.

The medical definition of Sulfapyridine is:

A sulfonamide antibacterial drug with a prolonged action, primarily used for its antimicrobial properties in treating various bacterial infections. It works by inhibiting the bacterial synthesis of folic acid, an essential component for bacterial growth and survival. Sulfapyridine is often combined with other medications, such as pyrimethamine, to enhance its antibacterial effect in specific therapeutic applications.

It's important to note that sulfonamides can cause side effects, including rashes, allergic reactions, and gastrointestinal symptoms. In some cases, more severe adverse reactions may occur, particularly in individuals with a known hypersensitivity to sulfa drugs or those with specific genetic factors. Always consult with a healthcare professional for appropriate use, dosage, and potential side effects of Sulfapyridine or any other medication.

Dermatitis is a general term that describes inflammation of the skin. It is often characterized by redness, swelling, itching, and tenderness. There are many different types of dermatitis, including atopic dermatitis (eczema), contact dermatitis, seborrheic dermatitis, and nummular dermatitis.

Atopic dermatitis is a chronic skin condition that often affects people with a family history of allergies, such as asthma or hay fever. It typically causes dry, scaly patches on the skin that can be extremely itchy.

Contact dermatitis occurs when the skin comes into contact with an irritant or allergen, such as poison ivy or certain chemicals. This type of dermatitis can cause redness, swelling, and blistering.

Seborrheic dermatitis is a common condition that causes a red, itchy rash, often on the scalp, face, or other areas of the body where oil glands are located. It is thought to be related to an overproduction of oil by the skin's sebaceous glands.

Nummular dermatitis is a type of eczema that causes round, coin-shaped patches of dry, scaly skin. It is more common in older adults and often occurs during the winter months.

Treatment for dermatitis depends on the underlying cause and severity of the condition. In some cases, over-the-counter creams or lotions may be sufficient to relieve symptoms. Prescription medications, such as corticosteroids or immunosuppressants, may be necessary in more severe cases. Avoiding triggers and irritants can also help prevent flare-ups of dermatitis.

'Avena sativa' is the scientific name for a type of grass species known as common oat or cultivated oat. It is widely grown as a crop for its seed, which is used as a food source for both humans and animals. Oats are rich in fiber, vitamins, minerals, and antioxidants, making them a popular choice for breakfast cereals, baked goods, and animal feeds. In addition to their nutritional value, oats have also been used in traditional medicine for various purposes, such as treating skin irritation and promoting hair growth.

A gluten-free diet is a diet that excludes the consumption of gluten, a protein found in wheat, barley, and rye. This type of diet is often recommended for individuals with celiac disease, non-celiac gluten sensitivity, or wheat allergies. Adhering to a strict gluten-free diet can help manage symptoms, heal intestinal damage, and prevent further complications associated with these conditions.

The medical definition of 'Diet, Gluten-Free' includes:

1. Celiac Disease: An autoimmune disorder where the ingestion of gluten leads to damage in the small intestine. Following a gluten-free diet is crucial for individuals with celiac disease to prevent symptoms and associated health complications.
2. Non-Celiac Gluten Sensitivity (NCGS): A condition where individuals experience adverse reactions to gluten, but do not test positive for celiac disease or wheat allergy. A gluten-free diet can help alleviate symptoms in those with NCGS.
3. Wheat Allergy: An allergic reaction to proteins found in wheat, which may include gluten. Excluding gluten from the diet can help manage symptoms in individuals with wheat allergy.
4. Dermatitis Herpetiformis (DH): A skin manifestation of celiac disease characterized by an itchy, blistering rash. A gluten-free diet is often recommended to control DH symptoms and prevent intestinal damage.
5. Gluten Ataxia: A neurological disorder associated with celiac disease where gluten ingestion can cause issues with balance, coordination, and speech. A gluten-free diet may help improve these symptoms in individuals with gluten ataxia.

It is essential to consult a healthcare professional or a registered dietitian for guidance on following a gluten-free diet to ensure proper nutrition and to avoid cross-contamination from gluten sources.

In medical terms, the skin is the largest organ of the human body. It consists of two main layers: the epidermis (outer layer) and dermis (inner layer), as well as accessory structures like hair follicles, sweat glands, and oil glands. The skin plays a crucial role in protecting us from external factors such as bacteria, viruses, and environmental hazards, while also regulating body temperature and enabling the sense of touch.

Diet therapy is a medical treatment that involves using specific dietary modifications to manage or treat various medical conditions. This can include changing the types and amounts of food consumed, as well as adjusting the timing and frequency of meals. The goal of diet therapy is to provide the body with the necessary nutrients to support healing and maintain health while also addressing any specific dietary needs or restrictions related to a particular medical condition.

Diet therapy may be used to treat a wide range of conditions, including diabetes, heart disease, high blood pressure, obesity, food allergies and intolerances, gastrointestinal disorders, and kidney disease. For example, a person with diabetes may be placed on a diet that restricts sugar and simple carbohydrates to help manage their blood sugar levels, while a person with heart disease may be advised to follow a low-fat, high-fiber diet to reduce their risk of heart attack and stroke.

Diet therapy is often used in conjunction with other medical treatments, such as medication and surgery, and should be prescribed and monitored by a healthcare professional, such as a registered dietitian or a doctor who specializes in nutrition. It is important for individuals to follow their specific dietary recommendations closely in order to achieve the best possible outcomes.

A biopsy is a medical procedure in which a small sample of tissue is taken from the body to be examined under a microscope for the presence of disease. This can help doctors diagnose and monitor various medical conditions, such as cancer, infections, or autoimmune disorders. The type of biopsy performed will depend on the location and nature of the suspected condition. Some common types of biopsies include:

1. Incisional biopsy: In this procedure, a surgeon removes a piece of tissue from an abnormal area using a scalpel or other surgical instrument. This type of biopsy is often used when the lesion is too large to be removed entirely during the initial biopsy.

2. Excisional biopsy: An excisional biopsy involves removing the entire abnormal area, along with a margin of healthy tissue surrounding it. This technique is typically employed for smaller lesions or when cancer is suspected.

3. Needle biopsy: A needle biopsy uses a thin, hollow needle to extract cells or fluid from the body. There are two main types of needle biopsies: fine-needle aspiration (FNA) and core needle biopsy. FNA extracts loose cells, while a core needle biopsy removes a small piece of tissue.

4. Punch biopsy: In a punch biopsy, a round, sharp tool is used to remove a small cylindrical sample of skin tissue. This type of biopsy is often used for evaluating rashes or other skin abnormalities.

5. Shave biopsy: During a shave biopsy, a thin slice of tissue is removed from the surface of the skin using a sharp razor-like instrument. This technique is typically used for superficial lesions or growths on the skin.

After the biopsy sample has been collected, it is sent to a laboratory where a pathologist will examine the tissue under a microscope and provide a diagnosis based on their findings. The results of the biopsy can help guide further treatment decisions and determine the best course of action for managing the patient's condition.

The intestinal mucosa is the innermost layer of the intestines, which comes into direct contact with digested food and microbes. It is a specialized epithelial tissue that plays crucial roles in nutrient absorption, barrier function, and immune defense. The intestinal mucosa is composed of several cell types, including absorptive enterocytes, mucus-secreting goblet cells, hormone-producing enteroendocrine cells, and immune cells such as lymphocytes and macrophages.

The surface of the intestinal mucosa is covered by a single layer of epithelial cells, which are joined together by tight junctions to form a protective barrier against harmful substances and microorganisms. This barrier also allows for the selective absorption of nutrients into the bloodstream. The intestinal mucosa also contains numerous lymphoid follicles, known as Peyer's patches, which are involved in immune surveillance and defense against pathogens.

In addition to its role in absorption and immunity, the intestinal mucosa is also capable of producing hormones that regulate digestion and metabolism. Dysfunction of the intestinal mucosa can lead to various gastrointestinal disorders, such as inflammatory bowel disease, celiac disease, and food allergies.

The Fluorescent Antibody Technique (FAT), Direct is a type of immunofluorescence assay used in laboratory diagnostic tests. It is a method for identifying and locating specific antigens in cells or tissues by using fluorescent-labeled antibodies that directly bind to the target antigen.

In this technique, a sample (such as a tissue section or cell smear) is prepared and then treated with a fluorescently labeled primary antibody that specifically binds to the antigen of interest. After washing away unbound antibodies, the sample is examined under a fluorescence microscope. If the antigen is present in the sample, it will be visible as distinct areas of fluorescence, allowing for the direct visualization and localization of the antigen within the cells or tissues.

Direct FAT is commonly used in diagnostic laboratories to identify and diagnose various infectious diseases, including bacterial, viral, and fungal infections. It can also be used to detect specific proteins or antigens in research and clinical settings.

Intestinal diseases refer to a wide range of conditions that affect the function or structure of the small intestine, large intestine (colon), or both. These diseases can cause various symptoms such as abdominal pain, diarrhea, constipation, bloating, nausea, vomiting, and weight loss. They can be caused by infections, inflammation, genetic disorders, or other factors. Some examples of intestinal diseases include inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), celiac disease, Crohn's disease, ulcerative colitis, and intestinal infections. The specific medical definition may vary depending on the context and the specific condition being referred to.

Symptoms of dermatitis herpetiformis are often resolved if patients avoid a gluten-rich diet. Dermatitis herpetiformis often is ... "Dermatitis herpetiformis". www.uptodate.com. Retrieved 11 March 2019. Korossy SK (2010). "Non-Dermatitis Herpetiformis Gluten- ... "Dermatitis Herpetiformis". American Osteopathic College of Dermatology. "Dermatitis Herpetiformis". Retrieved 2015-04-20.[ ... "Dermatitis Herpetiformis". Patient UK. "Dermatitis Herpetiformis". National Digestive Diseases Information Clearinghouse. ...
Perioral dermatitis refers to a red bumpy rash around the mouth. Dermatitis herpetiformis symptoms include itching, stinging ... Dermatitis More severe dermatitis A patch of dermatitis that has been scratched Complex dermatitis People with eczema should ... There are several types of dermatitis including atopic dermatitis, contact dermatitis, stasis dermatitis and seborrhoeic ... Irritant contact dermatitis is sometimes misdiagnosed as atopic dermatitis. Stress can cause atopic dermatitis to worsen. ...
Dermatitis herpetiformis, an itchy cutaneous condition that has been linked to a transglutaminase enzyme in the skin, features ... In 1966, dermatitis herpetiformis was linked to gluten sensitivity. May has been designated as "Coeliac Awareness Month" by ... Dermatitis herpetiformis is included in other recommendations. The NICE also recommend offering serological testing for coeliac ... In the United States it is thought to affect between 1 in 1750 (defined as clinical disease including dermatitis herpetiformis ...
... contact dermatitis. Autoimmune conditions related to gluten include celiac disease, dermatitis herpetiformis, and gluten ataxia ... Dermatitis herpetiformis (DH), or Duhring-Brocq disease, is a chronic blistering skin autoimmune condition, characterized by ... Mendes FB, Hissa-Elian A, Abreu MA, Gonçalves VS (2013). "Review: dermatitis herpetiformis". An Bras Dermatol (Review). 88 (4 ... Antiga E, Caproni M (May 13, 2015). "The diagnosis and treatment of dermatitis herpetiformis". Clin Cosmet Investig Dermatol. 8 ...
2022). "Dermatitis Herpetiformis". StatPearls at National Center for Biotechnology Information. PMID 29630215.{{cite journal ... In addition to above, an unspecific spongiotic dermatitis can be consistent with nummular dermatitis, dyshidrotic dermatitis, ... Interface dermatitis with vacuolar change Interface dermatitis with lichenoid inflammation An interface dermatitis with ... Antiga, Emiliano; Caproni, Marzia (2015). "The diagnosis and treatment of dermatitis herpetiformis". Clinical, Cosmetic and ...
Jelinek's diagnosis is dermatitis herpetiformis. After Marat's death, his wife may have sold his bathtub to her journalist ... possibly dermatitis herpetiformis). In January 1792, he married the 26-year-old Simone Evrard in a common-law ceremony on his ...
... implications for dermatitis herpetiformis and gluten ataxia". Amino Acids. 39 (5): 1183-91. doi:10.1007/s00726-010-0554-y. PMID ...
Dermatitis herpetiformis in combination with a gluten-free diet. Dapsone may be used to treat brown recluse spider bites that ... Additionally, it has been used for acne, dermatitis herpetiformis, and various other skin conditions. Dapsone is available both ... anti-inflammatory and immunomodulatory effects are thought to be its mechanism of action in treating dermatitis herpetiformis. ...
Ueber eine noch wenig bekannte Hautkrankheit (Dermatitis circumscripta herpetiformis). in Vierteljahrsschrift für Dermatologie ...
It is also used in the treatment of Dermatitis herpetiformis, where it is an alternative therapy to Dapsone. ... Vilanova X, De Moragas JM (October 1959). "[Treatment of dermatitis herpetiformis (Duhring) and herpes gestationis with ...
Epidermal transglutaminase is the autoantigen, in humans, of dermatitis herpetiformis. A study on the mutation of keratinocyte ...
In the related condition dermatitis herpetiformis, in which small bowel changes are often found and which responds to dietary ... is the autoantigen of dermatitis herpetiformis". The Journal of Experimental Medicine. 195 (6): 747-57. doi:10.1084/jem. ...
May 2008). "Elevation of IgA anti-epidermal transglutaminase antibodies in dermatitis herpetiformis". Br. J. Dermatol. 159 (1 ... are the autoantibodies believed to cause dermatitis herpetiformis. ATA IgA are more frequently found in Celiac Disease (CD); ...
A study of patients with dermatitis herpetiformis or coeliac disease revealed significantly more gluten in the blood than ... Triticeae glutens are the primary cause of dermatitis herpetiformis (DH). Epidermal transglutaminase (eTG) is related to tTG ... comparison of dermatitis herpetiformis and celiac disease patients with normal controls". J. Invest. Dermatol. 79 (3): 186-189 ...
1984). "Antibodies to gliadin in adult coeliac disease and dermatitis herpetiformis". Digestion. 30 (4): 263-70. doi:10.1159/ ...
2002). "Epidermal transglutaminase (TGase 3) is the autoantigen of dermatitis herpetiformis". J. Exp. Med. 195 (6): 747-57. doi ...
Lymphangioma circumscriptum and dermatitis herpetiformis may also have a similar appearance. As with almost all sexually ... atopic dermatitis, and urethritis. Laboratory testing is often used to confirm a diagnosis of genital herpes. Laboratory tests ... 369 Eczema herpeticum is an infection with herpesvirus in patients with chronic atopic dermatitis may result in spread of ...
... is also known as pompholyx, a term originating from the Greek word for "bubble". Dermatitis herpetiformis - a ... Dyshidrosis is a type of dermatitis that is characterized by itchy blisters on the palms of the hands and bottoms of the feet. ... "What Is Atopic Dermatitis? Fast Facts". NIAMS. November 2014. Archived from the original on 27 July 2016. Retrieved 11 August ... "Vesicular hand dermatitis". Archived from the original on 2010-03-30. Retrieved 2010-04-07. Diepgen, Thomas L.; Agner, Tove; ...
He is best remembered for having delineated dermatitis herpetiformis (also known as Duhring's disease); but he also described ... pruritus hiemalis ("winter itch"), and seborrheic dermatitis. After a stint with the 32nd Regiment of Pennsylvania Volunteers ...
IgA and IgG responses, meanwhile, like those seen to anti-gliadin antibodies in celiac disease or dermatitis herpetiformis, are ... 2015). "The gluten-free diet and its current application in coeliac disease and dermatitis herpetiformis". United European ... Food allergies to oats can accompany atopy dermatitis. Oat avenins share similarities with γ and ω-gliadins of wheat - based on ... Studies on farmers with grain dust allergy and children with atopy dermatitis reveal that oat proteins can act as both ...
2015). "The gluten-free diet and its current application in coeliac disease and dermatitis herpetiformis". United European ... non-celiac gluten sensitivity or dermatitis herpetiformis. Nevertheless, buckwheat products may have gluten contamination. ...
2015). "The gluten-free diet and its current application in coeliac disease and dermatitis herpetiformis". United European ...
2015). "The gluten-free diet and its current application in coeliac disease and dermatitis herpetiformis". United European ...
It can appear similar to porphyria cutanea tarda, pemphigoid, pemphigus, dermatitis herpetiformis, or blistering drug eruption ... It can appear similar to porphyria cutanea tarda, pemphigoid, pemphigus, dermatitis herpetiformis, or blistering drug eruption ...
The only treatment for CD, dermatitis herpetiformis (DH) and gluten ataxia is lifelong adherence to a GFD. Hischenhuber C, ... dermatitis herpetiformis, and wheat allergy. In these people, the gluten-free diet is the only available treatment. The ...
The only treatment for CD, dermatitis herpetiformis (DH) and gluten ataxia is lifelong adherence to a GFD. Hischenhuber C, ...
The only treatment for CD, dermatitis herpetiformis (DH) and gluten ataxia is lifelong adherence to a GFD. Hischenhuber C, ...
The only treatment for CD, dermatitis herpetiformis (DH) and gluten ataxia is lifelong adherence to a GFD. Hischenhuber C, ... dermatitis herpetiformis and wheat allergy. Gluten-free, casein-free diet: A gluten-free diet which also avoids casein, a ...
Dermatitis herpetiformis: a skin disease that causes intensely itchy blisters, usually on the elbows, knees, back and buttocks ... This is known as contact dermatitis. Blisters can also develop as a result of an allergic reaction to an insect bite or sting. ...
Their discovery continues to define the diagnostic "gold standard" for these diseases, as well as for dermatitis herpetiformis ...
Symptoms of dermatitis herpetiformis are often resolved if patients avoid a gluten-rich diet. Dermatitis herpetiformis often is ... "Dermatitis herpetiformis". www.uptodate.com. Retrieved 11 March 2019. Korossy SK (2010). "Non-Dermatitis Herpetiformis Gluten- ... "Dermatitis Herpetiformis". American Osteopathic College of Dermatology. "Dermatitis Herpetiformis". Retrieved 2015-04-20.[ ... "Dermatitis Herpetiformis". Patient UK. "Dermatitis Herpetiformis". National Digestive Diseases Information Clearinghouse. ...
Posts about Dermatitis Herpetiformis written by What Doctors Dont Tell You and Elson M. Haas MD ... At the age of four months, my son Edward developed seborrhoeic dermatitis. It started as a dry eczema patch on his forehead, ... Q I recently contracted dermatitis, probably as a result of all the painkillers and antibiotics I was given after minor knee ...
Dermatitis herpetiformis (DH) is an autoimmune blistering disorder associated with a gluten-sensitive enteropathy (GSE). The ... Associations of HLA and dermatitis herpetiformis are as follows:. * For HLA-B8: Association with dermatitis herpetiformis is 58 ... Patients with dermatitis herpetiformis and no apparent GI disease can be induced into developing dermatitis herpetiformis by ... In patients with dermatitis herpetiformis, 10-15% of their first-degree relatives have dermatitis herpetiformis or celiac ...
Treatment with a gluten-free diet is successful in patients with dermatitis herpetiformis, even in the absence of symptomatic ... Patients with dermatitis herpetiformis and their first-degree relatives are at increased risk for other autoimmune diseases, ... Treatment with a gluten-free diet is successful in greater than 70% of patients with dermatitis herpetiformis, even in the ... Treatment with a gluten-free diet is successful in greater than 70% of patients with dermatitis herpetiformis, but excellent ...
Rituximab treatment for recalcitrant dermatitis herpetiformis. JAMA Dermatol 2017; 153: 315-8.. 3. Collin P, et al. Dermatitis ... Rituximab therapy for recalcitrant dermatitis herpetiformis: A gut feeling. By Warren R. Heymann, MD. March 20, 2017. ... Dermatitis herpetiformis. Grouped papulovesicles with excoriations on the extensor surface of the shoulder.. Credit: JAAD. ... 1. Antiga E, Caproni M. The diagnosis and treatment of dermatitis herpetiformis. Clin Cosmet Investig Dermatol2015; 8: 257-65. ...
The National Library of Medicine (NLM), on the NIH campus in Bethesda, Maryland, is the worlds largest biomedical library and the developer of electronic information services that delivers data to millions of scientists, health professionals and members of the public around the globe, every day.
Dermatitis herpitiformis is a skin disorder that manifests in the form of small fluid-filled blisters. Itchiness and blisters ... Dermatitis herpetiformis is a skin disorder that manifests in the form of small fluid-filled blisters. Itchiness and blisters ... Opting for a diet free of gluten is recommended for the treatment of dermatitis herpitiformis. Foods like malts, wheat, barley ... Medication and a change in diet are known to be sufficient for the treatment of dermatitis herpitiformis. ...
Ueber das gleichzeitige Vorkommen einer Neurofibromatose und Dermatitis herpetiformis Duhring.. Subject(s):. Skin (Diseases of ... Blutbild bei Dermatitis herpetiformis Duhring, unter dem Einfluss der Behandlung (Salvarsan und Serum).. ... Blutbefund bei Dermatitis herpetiformis Dühring, unter dem Einfluss der Behandlung. (Salvarsan und Serum.). ... Die Neurofibromatose und ihre Komplikation mit der Dermatitis herpetiformis.. Subject(s):. Neurofibromatosis (Complications and ...
... in Adult. Print Images (52) Contributors: Erin X. Wei MD, Lauren Strazzula MD, Belinda Tan MD, PhD, ... Dermatitis herpetiformis (DH) is a chronic, pruritic autoimmune blistering disorder associated with gluten-sensitive ... Atopic dermatitis is also pruritic, with ill-defined, weeping, erythematous plaques.. *Herpes simplex virus has nonsymmetric, ... L13.0 - Dermatitis herpetiformis. SNOMEDCT:. 111196000 - Dermatitis herpetiformis. Look For. Copy. Subscription Required ...
Home Acne Durhings Disease Or Dermatitis Herpetiformis Who Is At Risk?. Acne Durhings Disease Or Dermatitis Herpetiformis Who ... Be aware of this skin condition if you suffer with Celiac disease - Dermatitis Herpetiformis #HealthStatus ... Diagnosis of Dermatitis Herpetiformis relies on a doctors diagnosis. It can sometimes be misdiagnosed as eczema. If you ... Dermatitis herpetiformis also known as Durhings disease is a rare chronic skin condition. Durhings disease affects between ...
Discover ten natural remedies for Dermatitis Herpetiformis, a chronic skin condition caused by gluten sensitivity, to manage ... Natural Remedies for Dermatitis Herpetiformis. In addition to a gluten-free diet, several natural remedies and supplements can ... Dermatitis Herpetiformis (DH) is a skin manifestation of celiac disease, an autoimmune disorder that causes damage to the small ... In conclusion, Dermatitis Herpetiformis can be challenging to manage, but natural remedies and supplements can relieve symptoms ...
Dermatitis Herpetiformis : Familiar and Unknown. Home / Dermatology / Dermatitis Herpetiformis : Familiar and Unknown ... Dermatitis herpetiformis is an autoimmune condition of the skin. It can be induced by gluten intake in genetically susceptible ... HLA association with dermatitis herpetiformis is accounted for by a cis or transassociated DQ heterodimer. Gut. 1991;32(5):487- ... Dermatitis herpetiformis can go into remission, according to researchers at the National Institutes of Health.30 That study ...
Dermatitis herpetiformis. Clin Dermatol. 2001;19:728-36.,1313 Reunala T. Incidence of familial dermatitis herpetiformis. Br J ... Dermatitis Herpetiformis (DH), also known as Duhring-Brocq dermatitis, is a chronic, recurrent disease, secondary to gluten ... herpetiformis. J Eur Acad Dermatol Venereol. 2009;23:633-8.,66 Fry L. Dermatitis herpetiformis: problems, progress and ... herpetiformis. J Eur Acad Dermatol Venereol. 2009;23:633-8.,66 Fry L. Dermatitis herpetiformis: problems, progress and ...
Atypical manifestations of disseminated cutaneous botryomycosis mimicking dermatitis herpetiformis in an immunocompetent adult ... The diagnosis of scabies was ruled out and a provisional diagnosis of dermatitis herpetiformis was considered. Findings from ... The authors found that these kind of lesions mimicking dermatitis herpetiformis have been reported only once, in prior ... Atypical manifestations of disseminated cutaneous botryomycosis mimicking dermatitis herpetiformis in an immunocompetent adult ...
Dermatitis Herpetiformis - Learn about the causes, symptoms, diagnosis & treatment from the MSD Manuals - Medical Consumer ... Despite its name, dermatitis herpetiformis has nothing to do with the herpesvirus. The term herpetiformis is used to describe ... The diagnosis of dermatitis herpetiformis is based on a skin biopsy Biopsy Doctors can identify many skin disorders simply by ... People with dermatitis herpetiformis often have celiac disease Celiac Disease Celiac disease is a hereditary intolerance to ...
Cohen and Frank accurately restate our position that the diagnostic criteria for dermatitis herpetiformis (DH) should be the ... Cohen and Frank accurately restate our position that the diagnostic criteria for dermatitis herpetiformis (DH) should be the ... DERMATITIS HERPETIFORMIS-Reply. Arch Dermatol. 1970;101(2):251. doi:10.1001/archderm.1970.04000020121022 ...
The protective effect of vitamin E on the hemolysis associated with dapsone treatment in patients with dermatitis herpetiformis ... DESIGN: Fifteen consecutive patients with dermatitis herpetiformis taking dapsone therapy received, in addition, 800 U/d of ... C and vitamin E would protect the erythrocyte from oxidant damage caused by dapsone in patients with dermatitis herpetiformis. ... daily for 4 weeks confers partial protective effect against dapsone-induced hemolysis in patients with dermatitis herpetiformis ...
Discover the comprehensive guide to spotting Dermatitis Herpetiformis symptoms. This informative article provides expert ... Spotting Dermatitis Herpetiformis: A Guide to Symptoms. Spotting Dermatitis Herpetiformis: A Guide to Symptoms is crucial for ... What is Dermatitis Herpetiformis?. Dermatitis Herpetiformis is a chronic skin condition characterized by the presence of ... Living with Dermatitis Herpetiformis. Living with Dermatitis Herpetiformis can be challenging, but with proper management, ...
Men are more likely to develop dermatitis herpetiformis than women.. 5. Stress: Stress can trigger or worsen dermatitis ... 3. Age: Dermatitis herpetiformis is most common in young adults, but it can occur at any age.. 4. Gender: ... Dermatitis herpetiformis is a chronic skin condition characterized by an itchy, blistering rash. It is caused by an abnormal ... Dermatitis herpetiformis is an autoimmune skin disorder caused by an abnormal immune response to gluten, a protein found in ...
Dermatitis herpetiformis (DH) is an autoimmune blistering disorder associated with a gluten-sensitive enteropathy (GSE). The ... encoded search term (Dermatitis Herpetiformis) and Dermatitis Herpetiformis What to Read Next on Medscape ... Dermatitis Herpetiformis Differential Diagnoses. Updated: Mar 31, 2016 * Author: Jami L Miller, MD; Chief Editor: Dirk M Elston ... Dermatitis herpetiformis and partial IgA deficiency. J Am Acad Dermatol. 2006 May. 54(5 Suppl):S206-9. [QxMD MEDLINE Link]. ...
Copy For Citation BÜLBÜL BAŞKAN E., YAZİCİ S. 9. Çukurova Dermatoloji Günleri.Dermatolojide tedavi, Adana, Turkey, 23 - 27 May 2012, vol.2012 ...
Dermatitis herpetiformis is associated with high prevalence of other autoimmune diseases. Classification. Dermatitis ... American Roentgen Ray Society Images of Dermatitis herpetiformis classification All Images. X-rays. Echo & Ultrasound. CT ... Dermatitis Herpetiformis (also called Duhrings disease), is a chronic itchy rash which is frequently associated with Celiac ... Retrieved from "https://www.wikidoc.org/index.php?title=Dermatitis_herpetiformis_classification&oldid=1688880" ...
Duhring herpetiformis dermatitis - Duhringova choroba, l nek potravinov alergie ... Popis choroby Duhring herpetiformis dermatitis. V skyt siln sv d c ch puch k i ekz mu na typick ch m stech, zejm na v okol velk ... Duhring herpetiformis dermatitis - Duhringova choroba. Mezi velice m lo zn m , v pov dom nejen laick ve ejnosti, ale bohu el i ... P idru en onemocn n k duhring herpetiformis dermatitis. Stejn jako u Celiakie se u t to choroby vyskytuj mo n p idru en onemocn ...
Dermatitis Herpetiformis is associated with coeliac disease - Reviewed by a GP. ... Dermatitis herpetiformis (DH) is an autoimmune blistering skin disease. ... Dermatitis Herpetiformis. In this article. * What is dermatitis herpetiformis? * How common is dermatitis herpetiformis? ( ... What is dermatitis herpetiformis?. Dermatitis herpetiformis (DH) is an autoimmune blistering skin disease associated with ...
Dermatitis herpetiformis is an autoimmune skin disorder caused by gluten sensitivity. Learn more about it at 10FAQ. ... Dermatitis herpetiformis goes under many names, including Duhrings disease, DH, celiac rash or gluten rash. Its a chronic ... Almost all dermatitis herpetiformis patients have an asymptomatic form of celiac disease. This condition is often recognized as ... People of all ages can get dermatitis herpetiformis. However, people between the ages of 30 and 40 are the most likely to be ...
2. Reunala T. Dermatitis herpetiformis. Clin Dermatol. 2001;19:728-36.. 3. Gawkrodger DJ, Blackwell JN, Gilmour HM, Rifkind EA ... Dermatitis herpetiformis:Diagnosis, diet and demography. Gut. 1984;25:151-7.. 4. Ouattara GF. Aspects épidémiologiques, ... Background: Dermatitis herpetiformis is a rare autoimmune bullous dermatosis that predominantly affects Caucasians, adults or ... Conclusion: Our study confirmed that dermatitis herpetiformis is rare in our context. It is more frequent in young children and ...
Visit Our Dermatitis Herpetiformis Page To Learn More Or Call Us Today! ... Dermatitis herpetiformis is an autoimmune skin disease that causes recurrent, intensely itchy blisters to form on the elbows, ...
... dermatitis herpetiformis stress bumps on fingers, dermatitis herpetiformis pictures, mild dermatitis herpetiformis, dermatit ... Treatment of Dermatitis Herpetiformis. Treatment for dermatitis herpetiformis will be adjusted to the symptoms that appear and ... Prevention of Dermatitis Herpetiformis. Not yet known how to prevent dermatitis herpetiformis. However, for celiac sufferers, ... Causes of Dermatitis Herpetiformis. Dermatitis herpetiformis is caused by an autoimmune disease, which is a condition in which ...
Chronic bullous diseases (dermatitis herpetiformis, pemphigoid) answers are found in the Evidence-Based Medicine Guidelines ... Chronic Bullous Diseases (dermatitis Herpetiformis, Pemphigoid) [Internet]. In: Evidence-Based Medicine Guidelines. Duodecim ... Chronic bullous diseases (dermatitis herpetiformis, pemphigoid). (2019). In Evidence-Based Medicine Guidelines. Duodecim ... "Chronic Bullous Diseases (dermatitis Herpetiformis, Pemphigoid)." Evidence-Based Medicine Guidelines, Duodecim Medical ...
Prevalence of Dermatitis Herpetiformis in iCureCeliac Patient Registry. The following study, which examines the prevalence of ... dermatitis herpetiformis (DH), was made possible by the Foundations iCureCeliac® patient registry. ...
  • Dermatitis herpetiformis (DH) is a chronic autoimmune blistering skin condition, characterised by intensely itchy blisters filled with a watery fluid. (wikipedia.org)
  • Dermatitis herpetiformis is an autoimmune disorder causing clusters of intensely itchy, red blisters and hivelike swellings in people who have celiac disease. (msdmanuals.com)
  • Dermatitis Herpetiformis is a chronic skin condition characterized by the presence of intensely itchy, blistering skin lesions. (bldgactive.com)
  • Dermatitis herpetiformis is a chronic skin condition characterized by an itchy, blistering rash. (rarediseaseshealthcenter.com)
  • Dermatitis Herpetiformis (also called Duhring's disease ), is a chronic itchy rash which is frequently associated with Celiac Disease . (wikidoc.org)
  • Dermatitis herpetiformis is an intensely itchy bullous rash characterised clinically by grouped vesicles on an erythematous base. (patient.info)
  • Dermatitis herpetiformis is an autoimmune skin disease that causes recurrent, intensely itchy blisters to form on the elbows, knees, back, buttocks, and/or scalp. (choicedermatology.com)
  • Dermatitis herpetiformis is a very painful and itchy skin rash that affects about 10% of people with celiac disease. (healthline.com)
  • Dermatitis herpetiformis (DH) is an autoimmune extremely itchy, painful bullous skin rash (blistering eruptions) arising from the underlying dermis layer of skin as a consequence of gluten sensitivity. (glutenfreeworks.com)
  • This skin rash, called dermatitis herpetiformis, causes itchy bumps and blisters. (medlineplus.gov)
  • [ 3 ] Among patients with celiac disease, 15-25% develop dermatitis herpetiformis. (medscape.com)
  • There is data to support that dermatitis herpetiformis and celiac disease can be associated with both T-cell and B-cell lymphoma. (medscape.com)
  • Dermatitis Herpetiformis (DH) is a skin manifestation of celiac disease, an autoimmune disorder that causes damage to the small intestine when gluten is ingested. (earthclinic.com)
  • 2 2 Hervonen K, Karell K, Holopainen P, Collin P, Partanen J, Reunala T. Concordance of dermatitis herpetiformis and celiac disease in monozygous twins. (scielo.br)
  • Dermatitis Herpetiformis, often abbreviated as DH, is a skin condition associated with celiac disease. (bldgactive.com)
  • Dermatitis Herpetiformis, often referred to as "DH," is a rare autoimmune skin disorder closely linked to celiac disease. (bldgactive.com)
  • Q: Can Dermatitis Herpetiformis occur without celiac disease? (bldgactive.com)
  • A: Dermatitis Herpetiformis is strongly associated with celiac disease, but in rare cases, it can occur independently. (bldgactive.com)
  • About 10 to 25 percent of people who are diagnosed with celiac disease also have dermatitis herpetiformis. (10faq.com)
  • Almost all dermatitis herpetiformis patients have an asymptomatic form of celiac disease. (10faq.com)
  • Dermatitis herpetiformis is a chronic blistering rash that often occurs in people with celiac disease. (bodyhealthmagz.com)
  • Will an eventual drug treatment for celiac disease also benefit those with dermatitis herpetiformis? (celiac.org)
  • If your provider suspects you have dermatitis herpetiformis, a blood test and intestinal or skin biopsy is needed to diagnose celiac disease. (medlineplus.gov)
  • OBJECTIVE: This study looked at whether oral vitamin C and vitamin E would protect the erythrocyte from oxidant damage caused by dapsone in patients with dermatitis herpetiformis. (mcmaster.ca)
  • RESULTS: Statistical analysis of the results suggests that oral administration of 800 units of vitamin E daily for 4 weeks confers partial protective effect against dapsone-induced hemolysis in patients with dermatitis herpetiformis. (mcmaster.ca)
  • We report a patient with severe dermatitis herpetiformis (DH) who was intolerant of dapsone, sulphapyridine, systemic steroids, and azathioprine. (elsevierpure.com)
  • lt;p class="First">Dapsone-USP, 4,4'-diaminodiphenylsulfone (DDS), is a primary treatment for Dermatitis herpetiformis. (nih.gov)
  • It's possible you have contact dermatitis which is an allergic response to something that touched or got on your skin. (wrinkle-free-skin-tips.com)
  • Touching the peels of citrus fruits can cause a skin reaction called contact dermatitis. (medicalnewstoday.com)
  • Cosmetics and perfumes often contain limonene, a compound in citrus peels that can cause contact dermatitis. (medicalnewstoday.com)
  • The main autoantigen of dermatitis herpetiformis is epidermal transglutaminase (eTG), a cytosolic enzyme involved in cell envelope formation during keratinocyte differentiation. (wikipedia.org)
  • Sardy M, Karpati S, Merkl B, Paulsson M, Smyth N. Epidermal transglutaminase (TGase 3) is the autoantigen of dermatitis herpetiformis. (medscape.com)
  • Short description: Other atopic dermatitis. (icd9data.com)
  • The primary outcome of interest was a diagnosis of atopic dermatitis by the child's second birthday. (medscape.com)
  • Dermatitis herpetiformis symptoms are chronic, and they tend to come and go, mostly in short periods of time in response to the amount of gluten ingested. (wikipedia.org)
  • Dermatitis herpetiformis (DH) is a chronic, pruritic autoimmune blistering disorder associated with gluten-sensitive enteropathy . (logicalimages.com)
  • Dermatitis Herpetiformis (DH), also known as Duhring-Brocq dermatitis, is a chronic, recurrent disease, secondary to gluten hypersensitivity which main clinical manifestation is the occurrence of a papulovesicular pruriginous rash. (scielo.br)
  • Although the first signs and symptoms of dermatitis herpetiformis are intense itching and burning, the first visible signs are the small papules or vesicles that usually look like red bumps or blisters. (wikipedia.org)
  • In addition to a gluten-free diet, several natural remedies and supplements can help manage the symptoms of Dermatitis Herpetiformis. (earthclinic.com)
  • It's important to note that while natural remedies can help manage the symptoms of Dermatitis Herpetiformis, they should not be used as a substitute for medical treatment. (earthclinic.com)
  • What are the symptoms of Dermatitis Herpetiformis? (rarediseaseshealthcenter.com)
  • 2. Medications: In addition to a gluten-free diet, medications may be prescribed to help reduce the symptoms of dermatitis herpetiformis. (rarediseaseshealthcenter.com)
  • 4. Phototherapy: Phototherapy, or light therapy, may be used to help reduce the symptoms of dermatitis herpetiformis. (rarediseaseshealthcenter.com)
  • Symptoms of dermatitis herpetiformis usually subside when the sufferer is on a gluten-free diet. (bodyhealthmagz.com)
  • Check with your doctor if you experience the symptoms of dermatitis herpetiformis as mentioned above, especially if they get worse. (bodyhealthmagz.com)
  • Doctors diagnose dermatitis herpetiformis by examining skin samples under a microscope. (msdmanuals.com)
  • To diagnose dermatitis herpetiformis, the doctor will first ask the patient about the symptoms they are experiencing and their medical history. (bodyhealthmagz.com)
  • The diagnosis of dermatitis herpetiformis (DH) is made on the basis of skin biopsy results. (medscape.com)
  • Dermatitis herpetiformis: pathophysiology, clinical presentation, diagnosis and treatment * * Work performed at West Paraná State University (UNIOESTE) - Cascavel (PR), Brazil. (scielo.br)
  • Guidelines for the diagnosis and treatment of dermatitis herpetiformis. (scielo.br)
  • Spotting Dermatitis Herpetiformis: A Guide to Symptoms is crucial for early diagnosis and management. (bldgactive.com)
  • If you suspect you have Dermatitis Herpetiformis, consult a healthcare professional for a proper diagnosis and treatment plan. (bldgactive.com)
  • this may reflect greater awareness and earlier diagnosis of coeliac disease (including via increased use of serological screening), leading to less time for dermatitis herpetiformis to develop. (patient.info)
  • It is a bullous-type dermatitis, extremely pruritic, and uncomfortable. (ndnr.com)
  • Expression of selected ADAMs in bullous pemphigoid and dermatitis herpetiformis. (medscape.com)
  • Dermatitis herpetiformis is a rare autoimmune bullous dermatosis that predominantly affects Caucasians, adults or children, with a sex ratio of 1.8. (odermatol.com)
  • Dermatitis herpetiformis (DH) is a rare, recurrent auto-immune bullous dermatosis classically associated with gluten enteropathy. (odermatol.com)
  • Dermatitis herpetiformis (DH) is an autoimmune blistering skin disease associated with coeliac disease (gluten enteropathy). (patient.info)
  • Although about 80% of those with dermatitis herpetiformis show histopathological changes of coeliac disease on small intestinal biopsy, only 20% of these patients initially have symptoms of coeliac disease. (patient.info)
  • The association between coeliac disease (CD) and dermatitis herpetiformis (DH) is well known. (unipr.it)
  • We describe a case of recurrent impetigo herpetiformis in an 18-year-old pregnant woman who had normal serum calcium levels and responded well to prednisolone therapy. (medscape.com)
  • Dermatitis herpetiformis goes under many names, including Duhring's disease, DH, celiac rash or gluten rash. (10faq.com)
  • Treatment with a gluten-free diet is successful in greater than 70% of patients with dermatitis herpetiformis, but excellent adherence to the diet is required for a minimum of 3 to 12 months. (kevinmd.com)
  • Treatment with a gluten-free diet is successful in greater than 70% of patients with dermatitis herpetiformis, even in the absence of symptomatic enteropathy. (kevinmd.com)
  • Dermatitis herpetiformis is an exquisitely pruritic eruption classically seen on the buttocks and the extensor surfaces of the arms and legs. (medscape.com)
  • Dermatitis herpetiformis is an intensely pruritic eruption that is associated with gluten-sensitive enteropathy . (webpathology.com)
  • Dermatitis herpetiformis is a skin disorder that manifests in the form of small fluid-filled blisters. (home-remedies-for-you.com)
  • The term herpetiformis is used to describe the way in which the blisters cluster together (similar to a rash caused by some herpesviruses). (msdmanuals.com)
  • Hall RP 3rd, Takeuchi F, Benbenisty KM, Streilein RD. Cutaneous endothelial cell activation in normal skin of patients with dermatitis herpetiformis associated with increased serum levels of IL-8, sE-Selectin, and TNF-alpha. (medscape.com)
  • Patients with dermatitis herpetiformis and their first-degree relatives are at increased risk for other autoimmune diseases, including thyroid disease, rheumatoid arthritis, and lupus erythematosus. (kevinmd.com)
  • Dermatitis herpetiformis is associated with high prevalence of other autoimmune diseases . (wikidoc.org)
  • A history of autoimmune diseases in the family is also common in people with dermatitis herpetiformis. (10faq.com)
  • Serum markers, such as IgA endomysial antibodies, are negative in as many as 10-37% of patients with dermatitis herpetiformis. (medscape.com)
  • Most, if not all, patients with dermatitis herpetiformis have gluten sensitivity, even when they have no evidence of enteropathy. (kevinmd.com)
  • Hall RP 3rd, Benbenisty KM, Mickle C, Streiien RD. Serum IL-8 in patients with dermatitis herpetiformis is produced in response to dietary gluten. (medscape.com)
  • Lahteenoja H, Irjala K, Viander M, Vainio E, Toivanen A, Syrjanen S. Oral mucosa is frequently affected in patients with dermatitis herpetiformis. (medscape.com)
  • Absence of toxicity of oats in patients with dermatitis herpetiformis. (medscape.com)
  • Prevalence of thyroid abnormalities in patients with dermatitis herpetiformis and in control subjects with HLA-B8/-DR3. (medscape.com)
  • [ 4 ] They are also relevant to dermatitis herpetiformis patients. (patient.info)
  • We collected 14 cases (0.12%) of dermatitis herpetiformis among 11,456 patients seen. (odermatol.com)
  • The role of apoptosis in the pathogenesis of dermatitis herpetiformis. (medscape.com)
  • The bullae found in the skin affected by dermatitis herpetiformis are subepidermal and have rounded lateral borders. (wikipedia.org)
  • Dermatitis herpetiformis is an autoimmune subepidermal blistering disorder that is often associated with a gluten-sensitive enteropathy (GSE). (medscape.com)
  • Elevation of IgA anti-epidermal transglutaminase antibodies in dermatitis herpetiformis. (medscape.com)
  • Transglutaminase autoantibodies in dermatitis herpetiformis and celiac sprue. (medscape.com)
  • Applying aloe vera gel directly to the affected areas can help reduce itching and inflammation associated with Dermatitis Herpetiformis. (earthclinic.com)
  • Omega-3 fatty acids are known for their anti-inflammatory properties and can help reduce the inflammation associated with Dermatitis Herpetiformis. (earthclinic.com)
  • Applying calendula cream or ointment to the affected areas can help reduce itching and inflammation associated with Dermatitis Herpetiformis. (earthclinic.com)
  • 3. Topical treatments: Topical treatments, such as creams and ointments, may be used to help reduce the itching and inflammation associated with dermatitis herpetiformis. (rarediseaseshealthcenter.com)
  • 1. Genetic predisposition: Dermatitis herpetiformis is strongly associated with the human leukocyte antigen (HLA) gene, which is responsible for the body's immune system. (rarediseaseshealthcenter.com)
  • Dermatitis herpetiformis is caused by an autoimmune disease, which is a condition in which the body's immune system attacks skin cells and tissues. (bodyhealthmagz.com)
  • I've done extensive research regarding types or rashes, but the only one that matches my symptoms exactly is Dermatitis Herpetiformis - the Celiac rash. (alifeofsugarandspice.com)
  • Dermatitis herpetiformis is characterized by grouped excoriations, erythematous, urticarial plaques, and papules with vesicles. (medscape.com)
  • Classic vesicles of dermatitis herpetiformis. (medscape.com)
  • The rash caused by dermatitis herpetiformis forms and disappears in three stages. (wikipedia.org)
  • Dermatitis herpetiformis was first described by Louis Adolphus Duhring in 1884. (wikipedia.org)
  • Dermatitis herpetiformis (DH) is a clinical entity that has been revisited and characterized many times yet remains elusive. (ndnr.com)
  • Drs. Cohen and Frank accurately restate our position that the diagnostic criteria for dermatitis herpetiformis (DH) should be the same in children as in adults-clinical, histologic, and response to therapy. (jamanetwork.com)
  • The aim of this study was to document the clinical and epidemiological profiles of dermatitis herpetiformis and to detail its treatment in a hospital setting in order to increase our knowledge about this disease in our context and so to improve its management. (odermatol.com)
  • Our clinical study suggests that it is very important, especially for the general practitioner, to recognize a DH and in every child presenting with a dermatitis like that it will be mandatory to perform a laboratory research of both AGA and EMA. (unipr.it)
  • There is no role for cyclosporine, a lactose-free diet, or intravenous immune globulin in the treatment of dermatitis herpetiformis. (kevinmd.com)
  • Medication and a change in diet are known to be sufficient for the treatment of dermatitis herpitiformis . (home-remedies-for-you.com)
  • Opting for a diet free of gluten is recommended for the treatment of dermatitis herpitiformis. (home-remedies-for-you.com)
  • Treatment for dermatitis herpetiformis will be adjusted to the symptoms that appear and their severity. (bodyhealthmagz.com)
  • Permeability, zonulin production, and enteropathy in dermatitis herpetiformis. (medscape.com)
  • The classic location for dermatitis herpetiformis lesions is on the extensor surfaces of the elbows, knees, buttocks, and back. (medscape.com)
  • Dermatitis herpetiformis: from the genetics to the development of skin lesions. (scielo.br)
  • In conclusion, Dermatitis Herpetiformis can be challenging to manage, but natural remedies and supplements can relieve symptoms. (earthclinic.com)
  • In conclusion, Spotting Dermatitis Herpetiformis: A Guide to Symptoms is essential for anyone seeking to understand this challenging skin condition. (bldgactive.com)
  • The appearance of dermatitis herpetiformis is also thought to be related to genetic factors, namely due to mutations in the HLA-DQ2 and HLA-DQ8 genes. (bodyhealthmagz.com)
  • Dermatitis herpetiformis rarely occurs on the posterior (nuchal) scalp and face. (medscape.com)
  • Dermatitis herpetiformis often occurs in young adults but can occur in children and older people. (msdmanuals.com)
  • Apart from the skin, dermatitis herpetiformis can also cause dental and digestive problems. (bodyhealthmagz.com)
  • Impetigo herpetiformis is a rare non-infectious pustular dermatosis of pregnancy. (medscape.com)
  • Interestingly, the patient's mother had also experienced a generalised pustular dermatosis associated with hypocalcaemia during oral contraceptive use, which was diagnosed clinically and histologically as impetigo herpetiformis. (medscape.com)
  • Dermatitis herpetiformis is currently felt to be a direct manifestation of the immune reaction to gluten that begins in the intestine. (celiac.org)