Cyclohexylamines
Sweetening Agents
Taste qualities of solutions preferred by hamsters. (1/25)
Molecules of diverse chemical structure are sweet to humans and several lines of evidence (genetic, physiological, behavioral) suggest that there may be distinct sweet perceptual qualities. To address how many perceptual categories these molecules elicit in hamsters (Mesocricetus auratus), we studied patterns of generalization of conditioned taste aversions for seven sweeteners: 100 mM sucrose, 320 mM maltose, 32 mM D-phenylalanine, 3.2 mM sodium saccharin, 16 mM calcium cyclamate, 10 mM dulcin and 32 mM sodium m-nitrobenzene sulfonate. Each stimulus was preferred versus water in two-bottle intake tests and stimulated the chorda tympani nerve. For each of seven experimental groups the conditional stimulus (CS) was a sweetener and for the control group the CS was water. Apomorphine.HCl was injected i.p. after a CS was sampled and, after recovery, test stimuli (TS) were presented for 1 h daily. The intake (ml) of each TS consumed by experimental animals was compared with mean TS intake by the control group. Learned aversions for 18/21 stimulus pairs cross-generalized, resulting in a single cluster of generalization patterns for the seven stimuli. Cross-generalization failures (maltose-cyclamate, maltose-sucrose, cyclamate-NaNBS) may be the consequence of particular stimulus features (e.g. salience, cation taste), rather than the absence of a 'sucrose-like' quality. The results are consistent with a single hamster perceptual quality for a diverse set of chemical structures that are sweet to humans. (+info)Long-term toxicity and carcinogenicity study of cyclamate in nonhuman primates. (2/25)
Twenty-one monkeys (cynomolgus, rhesus, African green) were fed cyclamate (100 mg/kg and 500 mg/kg) in the diet five times per week from a few days after birth and continuing for up to 24 years. Malignant tumors were diagnosed in three 24-year-old cyclamate monkeys; these were metastatic colon carcinoma (rhesus; 500 mg/kg), metastatic hepatocellular carcinoma (cynomolgus; 500 mg/kg), and a small, well differentiated adenocarcinoma of the prostate (cynomolgus; 100 mg/kg). Benign tumors were found at necropsy in three females; these were adenoma of the thyroid gland (rhesus; 100 mg/kg) and two cases of leiomyoma of the uterus (rhesus; 100 mg/kg and 500 mg/kg). No tumors were detected in an age-matched control group of 16 monkeys. Examination of the testes revealed complete testicular atrophy in one of the old cyclamate monkeys, and focal germ cell aplasia (Sertoli-only tubules) in two other cyclamate monkeys. Focal spermatogenic interruption (maturation arrest) at various germ cell levels mixed with normal spermatogenesis was observed in both the cyclamate-treated and the control monkeys, all of which were over 20 years old. Measurements of terminal cyclohexylamine concentrations showed that three of the males dosed with cyclamate at 500 mg/kg were high converters, with plasma concentrations comparable to the levels that produce testicular atrophy in rats. However, only one of the three high converters showed histologic evidence of irregular spermatogenesis. The overall conclusion is that the testicular abnormalities and the sporadic cases of different malignancies found after more than 20 years of dosing do not provide clear evidence of a toxic or carcinogenic effect of sodium cyclamate in monkeys. (+info)Pseudo-streaming potentials in Necturus gallbladder epithelium. I. Paracellular origin of the transepithelial voltage changes. (3/25)
Apparent streaming potentials were elicited across Necturus gallbladder epithelium by addition or removal of sucrose from the apical bathing solution. In NaCl Ringer's solution, the transepithelial voltage (Vms) change (reference, basolateral solution) was positive with sucrose addition and negative with sucrose removal. Bilateral Cl- removal (cyclamate replacement) had no effect on the polarity or magnitude of the Vms change elicited by addition of 100 mM sucrose. In contrast, bilateral Na+ removal (tetramethylammonium [TMA+] replacement) inverted the Vms change (from 2.7 +/- 0.3 to -3.2 +/- 0.2 mV). Replacement of Na+ and Cl- with TMA+ and cyclamate, respectively, abolished the change in Vms. Measurements of cell membrane voltages and relative resistances during osmotic challenges indicate that changes in cell membrane parameters do not explain the transepithelial voltage changes. The initial changes in Vms were slower than expected from concomitant estimates of the time course of sucrose concentration (and hence osmolality) at the membrane surface. Paired recordings of the time courses of paracellular bi-ionic potentials (partial substitution of apical Na+ with tetrabutylammonium [TBA+]) revealed much faster time courses than those produced by sucrose addition, although the diffusion coefficients of sucrose and TBACl are similar. Hyperosmotic and hypoosmotic challenges yielded initial Vms changes at the same rate; thereafter, the voltage increased with hypoosmotic solution and decreased with hyperosmotic solution. These late voltage changes appear to result from changes in width of the lateral intercellular spaces. The early time courses of the Vms changes produced by osmotic challenge are inconsistent with the expectations for water-ion flux coupling in the junctions. We propose that they are pseudo-streaming potentials, i.e., junctional diffusion potentials caused by salt concentration changes in the lateral intercellular spaces secondary to osmotic water flow. (+info)Different functional roles of T1R subunits in the heteromeric taste receptors. (4/25)
The T1R receptors, a family of taste-specific class C G protein-coupled receptors, mediate mammalian sweet and umami tastes. The structure-function relationships of T1R receptors remain largely unknown. In this study, we demonstrate the different functional roles of T1R extracellular and transmembrane domains in ligand recognition and G protein coupling. Similar to other family C G protein-coupled receptors, the N-terminal Venus flytrap domain of T1R2 is required for recognizing sweeteners, such as aspartame and neotame. The G protein coupling requires the transmembrane domain of T1R2. Surprisingly, the C-terminal transmembrane domain of T1R3 is required for recognizing sweetener cyclamate and sweet taste inhibitor lactisole. Because T1R3 is the common subunit in the sweet taste receptor and the umami taste receptor, we tested the interaction of lactisole and cyclamate with the umami taste receptor. Lactisole inhibits the activity of the human T1R1/T1R3 receptor, and, as predicted, blocked the umami taste of l-glutamate in human taste tests. Cyclamate does not activate the T1R1/T1R3 receptor by itself, but potentiates the receptor's response to l-glutamate. Taken together, these findings demonstrate the different functional roles of T1R3 and T1R2 and the presence of multiple ligand binding sites on the sweet taste receptor. (+info)Artificial sweeteners--do they bear a carcinogenic risk? (5/25)
Artificial sweeteners are added to a wide variety of food, drinks, drugs and hygiene products. Since their introduction, the mass media have reported about potential cancer risks, which has contributed to undermine the public's sense of security. It can be assumed that every citizen of Western countries uses artificial sweeteners, knowingly or not. A cancer-inducing activity of one of these substances would mean a health risk to an entire population. We performed several PubMed searches of the National Library of Medicine for articles in English about artificial sweeteners. These articles included 'first generation' sweeteners such as saccharin, cyclamate and aspartame, as well as 'new generation' sweeteners such as acesulfame-K, sucralose, alitame and neotame. Epidemiological studies in humans did not find the bladder cancer-inducing effects of saccharin and cyclamate that had been reported from animal studies in rats. Despite some rather unscientific assumptions, there is no evidence that aspartame is carcinogenic. Case-control studies showed an elevated relative risk of 1.3 for heavy artificial sweetener use (no specific substances specified) of >1.7 g/day. For new generation sweeteners, it is too early to establish any epidemiological evidence about possible carcinogenic risks. As many artificial sweeteners are combined in today's products, the carcinogenic risk of a single substance is difficult to assess. However, according to the current literature, the possible risk of artificial sweeteners to induce cancer seems to be negligible. (+info)Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3. (6/25)
The artificial sweetener cyclamate tastes sweet to humans, but not to mice. When expressed in vitro, the human sweet receptor (a heterodimer of two taste receptor subunits: hT1R2 + hT1R3) responds to cyclamate, but the mouse receptor (mT1R2 + mT1R3) does not. Using mixed-species pairings of human and mouse sweet receptor subunits, we determined that responsiveness to cyclamate requires the human form of T1R3. Using chimeras, we determined that it is the transmembrane domain of hT1R3 that is required for the sweet receptor to respond to cyclamate. Using directed mutagenesis, we identified several amino acid residues within the transmembrane domain of T1R3 that determine differential responsiveness to cyclamate of the human versus mouse sweet receptors. Alanine-scanning mutagenesis of residues predicted to line a transmembrane domain binding pocket in hT1R3 identified six residues specifically involved in responsiveness to cyclamate. Using molecular modeling, we docked cyclamate within the transmembrane domain of T1R3. Our model predicts substantial overlap in the hT1R3 binding pockets for the agonist cyclamate and the inverse agonist lactisole. The transmembrane domain of T1R3 is likely to play a critical role in the interconversion of the sweet receptor from the ground state to the active state. (+info)Electrophysiological effects of extracellular ATP on Necturus gallbladder epithelium. (7/25)
The effects of addition of ATP to the mucosal bathing solution on transepithelial, apical, and basolateral membrane voltages and resistances in Necturus gallbladder epithelium were determined. Mucosal ATP (100 microM) caused a rapid hyperpolarization of both apical (Vmc) and basolateral (Vcs) cell membrane voltages (delta Vm = 18 +/- 1 mV), a fall in transepithelial resistance (Rt) from 142 +/- 8 to 122 +/- 7 omega.cm2, and a decrease in fractional apical membrane resistance (fRa) from 0.93 +/- 0.02 to 0.83 +/- 0.03. The rapid initial hyperpolarization of Vmc and Vcs was followed by a slower depolarization of cell membrane voltages and a lumen-negative change in transepithelial voltage (Vms). This phase also included an additional decrease in fRa. Removal of the ATP caused a further depolarization of membrane voltages followed by a hyperpolarization and then a return to control values. fRa fell to a minimum after removal of ATP and then returned to control values as the cell membrane voltages repolarized. Similar responses could be elicited by ADP but not by adenosine. The results of two-point cable experiments revealed that ATP induced an initial increase in cell membrane conductance followed by a decrease. Transient elevations of mucosal solution [K+] induced a larger depolarization of Vmc and Vcs during exposure to ATP than under control conditions. Reduction of mucosal solution [Cl-] induced a slow hyperpolarization of Vmc and Vcs before exposure to ATP and a rapid depolarization during exposure to ATP. We conclude that ATP4- is the active agent and that it causes a concentration-dependent increase in apical and basolateral membrane K+ permeability. In addition, an apical membrane electrodiffusive Cl- permeability is activated by ATP4-. (+info)Potential carcinogenicity of food additives and contaminants. (8/25)
The potential role in carcinogenesis of food additives and contaminants presents a complex problem in terms of assessing the risk to the general public. Long-term testing in laboratory animals is still the most feasible method for determining potential carcinogenicity of various chemicals. The disadvantages encountered in the present methods of animal testing are discussed and a review is made of the current status of particular food additives and contaminants under scrutiny as possible carcinogens. It is suggested that, since it may not be possible to remove all carcinogenic materials from the environment, methods to mitigate or neutralize their harmful effects should be sought. Greater cooperation is called for among food technologists, toxicologists, laboratory researchers, and epidemiologists in the decision-making process regarding the role of possibly carcinogenic additives and contaminants. (+info)Cyclamates are a type of artificial sweetener that were widely used in food and beverages as a sugar substitute until they were banned by the U.S. Food and Drug Administration (FDA) in 1970. They are synthetic derivatives of cyclamic acid, which is a naturally occurring compound found in some plants.
Cyclamates are approximately 30-50 times sweeter than sugar, making them an attractive alternative for people looking to reduce their calorie intake. However, studies conducted in the 1960s suggested that cyclamates may be associated with an increased risk of bladder cancer in rats, leading to their ban in the United States and several other countries.
While some countries still allow the use of cyclamates in certain food products, they remain a controversial ingredient due to ongoing concerns about their safety. The European Union has classified cyclamates as a category IV sweetener, which means that they are considered safe for human consumption in limited quantities, but their use is restricted to specific applications and maximum levels have been established.
Cyclohexylamines are a class of organic compounds that consist of a cyclohexane ring (a six-carbon saturated ring) with an amine group (-NH2, -NHR, or -NR2) attached to it. The amine group can be primary (one alkyl group attached to the nitrogen atom), secondary (two alkyl groups attached to the nitrogen atom), or tertiary (three alkyl groups attached to the nitrogen atom).
Cyclohexylamines have a wide range of applications in the chemical industry, including as intermediates in the synthesis of pharmaceuticals, agrochemicals, and dyes. Some cyclohexylamines are also used as solvents or extractants. However, some cyclohexylamines can be toxic or have harmful effects on human health, so they must be handled with care.
Saccharin is not a medical term, but it is a chemical compound that is widely used as an artificial sweetener. Medically speaking, saccharin is classified as an intense sugar substitute, meaning it is many times sweeter than sucrose (table sugar) but contributes little to no calories when added to food or drink.
Saccharin is often used by people with diabetes or those who are trying to reduce their calorie intake. It has been in use for over a century and has undergone extensive safety testing. The U.S. Food and Drug Administration (FDA) has classified saccharin as generally recognized as safe (GRAS), although it once required a warning label due to concerns about bladder cancer. However, subsequent research has largely dismissed this risk for most people, and the warning label is no longer required.
It's important to note that while saccharin and other artificial sweeteners can be helpful for some individuals, they should not be used as a replacement for a balanced diet and regular exercise. Additionally, excessive consumption of these sugar substitutes may have negative health consequences, such as altering gut bacteria or contributing to metabolic disorders.
Aspartame is a synthetic, low-calorie sweetener that is commonly used as a sugar substitute in foods and beverages. It is composed of two amino acids, aspartic acid and phenylalanine, and a methanol molecule. Aspartame is approximately 200 times sweeter than sugar, so only a small amount is needed to provide the same level of sweetness.
In the body, aspartame is broken down into its component parts during digestion. The aspartic acid and phenylalanine are absorbed and used for normal bodily functions, while the methanol is converted into formaldehyde and then formic acid, which are eliminated from the body.
Aspartame is approved for use in foods and beverages by many health authorities, including the U.S. Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA). However, it has been the subject of some controversy, with some studies suggesting that it may be associated with health problems such as headaches, dizziness, and seizures. These claims have not been consistently supported by scientific research, and the FDA and EFSA consider aspartame to be safe for the general population when used in moderation.
It is important to note that people with a rare genetic disorder called phenylketonuria (PKU) must avoid aspartame because they are unable to metabolize phenylalanine, which can build up to toxic levels in their bodies. Foods and beverages containing aspartame must carry a warning label indicating its presence for this reason.
Sweetening agents are substances that are added to foods or drinks to give them a sweet taste. They can be natural, like sugar (sucrose), honey, and maple syrup, or artificial, like saccharin, aspartame, and sucralose. Artificial sweeteners are often used by people who want to reduce their calorie intake or control their blood sugar levels. However, it's important to note that some sweetening agents may have potential health concerns when consumed in large amounts.
The large intestine, also known as the colon, is the lower part of the gastrointestinal tract that extends from the cecum, where it joins the small intestine, to the anus. It is called "large" because it has a larger diameter compared to the small intestine and is responsible for several important functions in the digestive process.
The large intestine measures about 1.5 meters (5 feet) long in adults and consists of four main regions: the ascending colon, transverse colon, descending colon, and sigmoid colon. The primary function of the large intestine is to absorb water and electrolytes from undigested food materials, compact the remaining waste into feces, and store it until it is eliminated through defecation.
The large intestine also contains a diverse population of bacteria that aid in digestion by breaking down complex carbohydrates, producing vitamins like vitamin K and some B vitamins, and competing with harmful microorganisms to maintain a healthy balance within the gut. Additionally, the large intestine plays a role in immune function and helps protect the body from pathogens through the production of mucus, antimicrobial substances, and the activation of immune cells.
Cyclamate
Cyclamate sulfohydrolase
Diet drink
John Mallette
Sugar substitute
Timeline of United States discoveries
Fizzies
Funny Face (drink mix)
Iron polymaltose
Diet Rite
Herbert L. Ley Jr.
Fresca
2005 Indonesia food scare
Tab (drink)
Sucralose
No-Cal
Sulfamic acid
Li hing mui
Sweetness
Tongaat Hulett
Saccharin
Sweet'n Low
Cyclamic acid
Glossary of diabetes
Assugrin
Rivella
Pillsbury (brand)
August 1970
Robert Cade
Neotame
Cyclamate - Wikipedia
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Sodium27
- Cyclamate is the sodium or calcium salt of cyclamic acid (cyclohexanesulfamic acid), which itself is prepared by reacting freebase cyclohexylamine with either sulfamic acid or sulfur trioxide. (wikipedia.org)
- Prior to 1973, Abbott Laboratories produced sodium cyclamate (Sucaryl) by a mixture of ingredients including the addition of pure sodium (flakes or rods suspended in solvent) with cyclohexylamine, chilled and filtered through a high speed centrifugal separator, dried, granulated and micro-pulverised for powder or tablet usage. (wikipedia.org)
- Sodium cyclamate, E 952 is a synthetic food sweetener with high sweetening power. (infocons.org)
- This by sulphonation with chlorosulphonic acid in chloroform and treatment with barium hydroxide and sulphuric acid forms sodium cyclamate. (infocons.org)
- It is 10 times more toxic than sodium cyclamate. (infocons.org)
- Cyclamate, chemically known as sodium cyclohexyl sulfamate, is a commonly used additive in food production. (joinedfortunechemical.com)
- In the world of sweeteners, sodium cyclamate stands out as a versatile and cost-effective option . (echem-bv.com)
- We're here to introduce you to the benefits of sodium cyclamate and why it's the perfect choice for your business. (echem-bv.com)
- What Is Sodium Cyclamate? (echem-bv.com)
- Why Choose Sodium Cyclamate? (echem-bv.com)
- fourthly, Sugar Reduction: With the growing consumer demand for reduced sugar products, sodium cyclamate can help you create healthier alternatives without sacrificing sweetness. (echem-bv.com)
- When purchasing sodium cyclamate for your business, it's crucial to source it from reputable suppliers who adhere to strict quality standards. (echem-bv.com)
- Incorporating sodium cyclamate into your product formulations can provide a competitive edge in today's health-conscious market. (echem-bv.com)
- Explore the possibilities of sodium cyclamate for sale and transform your products into healthier, more flavorful options. (echem-bv.com)
- It is the world's largest manufacturer of sodium cyclamate and China's biggest producer of cyclohexylamine. (byyoursidestudios.com)
- With many years' industry experiences in Mainland China, we have finished the first-phase construction of the production units for industrial cyclohexylamine, dicyclohexylamine and sodium cyclamate. (byyoursidestudios.com)
- This method makes it possible to determine five artificial sweeteners (acesulfame-K, aspartame, saccharine, sodium cyclamate and sucralose) in white wine (and white-wine-based beverages), within concentration ranges of up to 50 mg/L for saccharine, 125 mg/L for acesulfame-K and 250 mg/L for sucralose, sodium cyclamate and aspartame. (oiv.int)
- It appears in the composition of the products as sodium and calcium cyclamates and cyclamic acid. (uchile.cl)
- The purpose of this research was to assess the effect of sodium cyclamate in kidneys of rats fetuses considering morphometric changes of glomerulus, proximal and distal convoluted tubules, and collecting duct. (uchile.cl)
- Ten pregnant rat (Rattus norvegicus) weighting an average of 238 g were divided into two groups: 5 in the control group and 5 in treated group with sodium cyclamate. (uchile.cl)
- Between the 10th and the 14th pregnancy day, 5 rats received an intraperitoneal daily injection of 60 mg/kg of body weight of sodium cyclamate during 5 days. (uchile.cl)
- There were a significant decrease in fetal and placentae weight in treated group with sodium cyclamate (p = 0.004) when compared with control group. (uchile.cl)
- In the glomerular volume and cell nuclei size of proximal and distal convoluted tubules and collecting duct of kidneys of rats fetuses treated with sodium cyclamate, the increase was statistically significant. (uchile.cl)
- The results showed that the use of sodium cyclamate was effective in the reduction of fetal and placentae weight, and lenght of umbilical cords. (uchile.cl)
- Sodium cyclamate, which is popular in Europe, is around 30 to 40 times sweeter than traditional sugar. (jpost.com)
- Butylated-hydroxyanisol (25013165), butylated-hydroxytoluene (128370), D(+)tryptophan (153946), sodium-cyclamate (139059) and sodium-saccharin (128449) produced weak responses. (cdc.gov)
- 1996). For example, chlorophenol red selectively reacts with chlorine dioxide at pH 7 with a detection limit of 0.12 mg/L. The interferences from chlorine may be reduced by the addition of oxalic acid, sodium cyclamate, or thioacetamide (Sweetin et al. (cdc.gov)
Aspartame1
- Use of artificial sweeteners (AS) such as aspartame, cyclamate, saccharin and sucralose is widespread. (researchgate.net)
Sweeteners4
- the mixture of 10 parts cyclamate to 1 part saccharin is common and masks the off-tastes of both sweeteners. (wikipedia.org)
- In 1969 Federal govt bans use of artificial sweeteners known as cyclamates. (faqs.org)
- While Tab contained two artificial sweeteners - saccharin and cyclamate - cyclamate was the more important of the two. (snopes.com)
- Even though the government banned cyclamates in 1969, we have even more artificial sweeteners available today. (dennywaxman.com)
Artificial3
- Cyclamate is an artificial sweetener. (wikipedia.org)
- Cyclohexylamine (CAS # 108-91-8, EC # 203-629-0) is a human metabolite of the artificial sweetener cyclamate, which is produced by intestinal microflora. (infocons.org)
- The cyclamate is used as artificial non-caloric sweetner in a wide variety of foods and beverages, being 30 times as sweet as sugar without the bitter after-taste of saccharin. (uchile.cl)
Saccharin and cyclamate1
- Knowing that mixtures of saccharin and cyclamate exert reduced bitterness compared to the single compounds raised the question [of] whether this might be due to mutual inhibition of bitter taste receptor responses," Behrens said to Science Daily. (jpost.com)
19374
- citation needed] Cyclamate was discovered in 1937 at the University of Illinois by graduate student Michael Sveda. (wikipedia.org)
- Cyclamates are the salts of cyclohexylaminosulphonic acid discovered by Sveda as early as 1937. (infocons.org)
- Discovered in 1937, cyclamate was first marketed in 1949, and banned by the FDA as potentially harmful in 1970. (britannica.com)
- Kirsch wanted to create a soda for diabetics and people with cardiovascular problems, so he used cyclamate , which was discovered in 1937 by a graduate student working at a University of Illinois chemistry lab after he licked some of the substance and found that it tasted sweet. (snopes.com)
19694
- Further research resulted in a 1969 study that found the common 10:1 cyclamate-saccharin mixture increased the incidence of bladder cancer in rats. (wikipedia.org)
- Sales continued to expand, and in 1969, annual sales of cyclamate had reached $1 billion, which increased pressure from public safety watchdogs to restrict the usage of cyclamate. (wikipedia.org)
- Abbott Laboratories claimed that its own studies were unable to reproduce the 1969 study's results, and, in 1973, Abbott petitioned the FDA to lift the ban on cyclamate. (wikipedia.org)
- In 1969, the Food and Drug Administration banned the sweetener cyclamate after lab studies indicated that large doses of the sweetener led to bladder cancer in animals. (snopes.com)
Cyclohexylamine4
- citation needed] In 1966, a study reported that some intestinal bacteria could desulfonate cyclamate to produce cyclohexylamine, a compound suspected to have some chronic toxicity in animals. (wikipedia.org)
- In animals and humans, the ability of bacterial microflora to convert cyclamate to cyclohexylamine varies over time for the same individual. (infocons.org)
- Cyclohexylamine, which is the main metabolite of cyclamates, is formed mainly in the intestines under the influence of enterococci. (infocons.org)
- Cyclamates are largely not metabolised by the human body and therefore there is a risk to aquatic organisms and the environment if wastewater treatment plants do not effectively remove them and their main metabolite: cyclohexylamine. (infocons.org)
Bitterness1
- Abbott intended to use cyclamate to mask the bitterness of certain drugs such as antibiotics and pentobarbital. (wikipedia.org)
Carcinogen1
- Although the FDA has stated that a review of all available evidence does not implicate cyclamate as a carcinogen in mice or rats, cyclamate remains banned from food products in the United States. (wikipedia.org)
Rats1
- The released study was showing that eight out of 240 rats fed a mixture of saccharin and cyclamates, at levels equivalent to humans ingesting 550 cans of diet soda per day, developed bladder tumors. (wikipedia.org)
Chemicals1
- In 1970 a ruling of the United States Food and Drug Administration was sufficient to limit severely the use of a group of chemicals known as the cyclamates, many tons of which had been marketed annually in the country's favorite soft drinks and in many other food products. (druglibrary.org)
Products1
- in October 1970, the FDA, under a new commissioner, banned cyclamate completely from all food and drug products in the United States. (wikipedia.org)
Sugar1
- About 30 times sweeter than sugar, cyclamate isn't metabolized, making it ideal for people who need to avoid sugar. (snopes.com)
People2
- But there are also people in whom a large proportion of ingested cyclamate (60%) is metabolised. (infocons.org)
- With this ban, people were running to the stores to buy up the remaining cyclamate-sweetened sodas. (dennywaxman.com)
Countries2
- Cyclamate is approved as a sweetener in at least 130 countries. (wikipedia.org)
- Due to both carcinogenic, mutagenic, teratogenic effects, in some countries such as the USA, cyclamates are not allowed in the diet. (infocons.org)
Days1
- Generally, ingested cyclamate is excreted from the body within 1-2 days. (infocons.org)
Studies1
- The patent for cyclamate was purchased by DuPont and later sold to Abbott Laboratories, which undertook the necessary studies and submitted a New Drug Application in 1950. (wikipedia.org)
Study2
- The authors concluded that the study failed to demonstrate that cyclamate was carcinogenic because the cancers were all different and there was no way to link cyclamate to each of them. (wikipedia.org)
- A study in the journal Cell Chemical Biology uncovered that saccharin is able to inhibit the activity of bitter taste receptors, which are stimulated by cyclamate. (jpost.com)
Safe1
- In the Philippines, cyclamate was banned until the Philippine Food and Drug Administration lifted the ban in 2013, declaring it safe for consumption. (wikipedia.org)
Sweeteners3
- the mixture of 10 parts cyclamate to 1 part saccharin is common and masks the off-tastes of both sweeteners. (wikipedia.org)
- Structures of artificial sweeteners--cyclamic acid and sodium cyclamate with other cyclamates. (nih.gov)
- After just three weeks of testing, the Health, Education and Welfare Secretary abruptly declared a ban on cyclamate sweeteners. (encyclopedia.com)
Sweetener7
- Cyclamate is an artificial sweetener. (wikipedia.org)
- Cyclamate was marketed in tablet form for use by diabetics as an alternative tabletop sweetener, as well as in a liquid form. (wikipedia.org)
- Cyclamate is approved as a sweetener in at least 130 countries. (wikipedia.org)
- Objective information about low calorie sweetener cyclamate. (webstatsdomain.org)
- As artificial sweetener and sugar substitute, cyclamate has many uses, characteristics. (webstatsdomain.org)
- 1969 Cyclamate, a non-caloric sweetener, was banned. (foodimentary.com)
- For cyclamate, intake was above the ADI in some scenarios though the supposed direct replacement with sucrose may not be realistic for such sweetener that is normally used in lower amounts and in combination with other LNCS (due to its high sucrose sweetness equivalence). (sweeteners.org)
Saccharin and cyclamates2
- The released study was showing that eight out of 240 rats fed a mixture of saccharin and cyclamates, at levels equivalent to humans ingesting 550 cans of diet soda per day, developed bladder tumors. (wikipedia.org)
- The Eisenstadts developed a granular powder using saccharin and cyclamates, and named it Sweet ' n Low, after Benjamin Eisenstadt ' s favorite Tennyson poem. (encyclopedia.com)
Cyclamic acid1
- Cyclamate is the sodium or calcium salt of cyclamic acid (cyclohexanesulfamic acid), which itself is prepared by reacting freebase cyclohexylamine with either sulfamic acid or sulfur trioxide. (wikipedia.org)
Sucaryl1
- Prior to 1973, Abbott Laboratories produced sodium cyclamate (Sucaryl) by a mixture of ingredients including the addition of pure sodium (flakes or rods suspended in solvent) with cyclohexylamine, chilled and filtered through a high speed centrifugal separator, dried, granulated and micro-pulverised for powder or tablet usage. (wikipedia.org)
19702
- in October 1970, the FDA, under a new commissioner, banned cyclamate completely from all food and drug products in the United States. (wikipedia.org)
- In 1970 a ruling of the United States Food and Drug Administration was sufficient to limit severely the use of a group of chemicals known as the cyclamates, many tons of which had been marketed annually in the country's favorite soft drinks and in many other food products. (druglibrary.org)
20221
- The report forecast global Cyclamate market to grow to reach xxx Million USD in 2022 with a CAGR of xx% during the period 2022E-2028F due to coronavirus situation. (statsandresearch.com)
Ingredient1
- It was also a case of supremely bad luck, bad judgment, and a fateful ingredient known as cyclamate. (mentalfloss.com)
19961
- 1996). For example, chlorophenol red selectively reacts with chlorine dioxide at pH 7 with a detection limit of 0.12 mg/L. The interferences from chlorine may be reduced by the addition of oxalic acid, sodium cyclamate, or thioacetamide (Sweetin et al. (cdc.gov)
Citation1
- citation needed] In 1966, a study reported that some intestinal bacteria could desulfonate cyclamate to produce cyclohexylamine, a compound suspected to have some chronic toxicity in animals. (wikipedia.org)
Drugs1
- Abbott intended to use cyclamate to mask the bitterness of certain drugs such as antibiotics and pentobarbital. (wikipedia.org)
Beverage1
- Forty-nine women consumed a beverage containing 60 mg of cyclamate. (nih.gov)
Type1
- At the same time, we classify Cyclamate according to the type, application by geography. (statsandresearch.com)
Addition1
- But Marvin Eisenstadt was able to use his chemical expertise and devise a new formula for Sweet ' n Low, made with saccharin but without the addition of cyclamates. (encyclopedia.com)
Application2
- The patent for cyclamate was purchased by DuPont and later sold to Abbott Laboratories, which undertook the necessary studies and submitted a New Drug Application in 1950. (wikipedia.org)
- The market research includes historical and forecast market data, demand, application details, price trends, and company shares of the leading Cyclamate by geography. (statsandresearch.com)
Main1
- The report offers detailed coverage of Cyclamate industry and main market trends with impact of coronavirus. (statsandresearch.com)
Late1
- The ban was announced in late October, and all cyclamates were to be off the shelf by February 1. (encyclopedia.com)
Link1
- The authors concluded that the study failed to demonstrate that cyclamate was carcinogenic because the cancers were all different and there was no way to link cyclamate to each of them. (wikipedia.org)
Authors1
- In both models conducted by the authors the intake of all LNCS, except cyclamate, were below the ADI for all population groups. (sweeteners.org)
Status1
- First, this report covers the present status and the future prospects of the global Cyclamate market for 2018-2027. (statsandresearch.com)
Report1
- Finally, the report provides detailed profile and data information analysis of leading Cyclamate company. (statsandresearch.com)