Cinnarizine
Flunarizine
Bencyclane
Prenylamine
Calcium Channel Blockers
Accidents, Home
Functional overlap of IP(3)- and cADP-ribose-sensitive calcium stores in guinea pig myenteric neurons. (1/49)
In myenteric neurons two different receptor subtypes govern the intracellular Ca(2+) stores: the inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R) and the ryanodine receptor (RyR). Their degree of functional overlap was determined by examining Ca(2+) release in these cells through both superfusion techniques and intracellular microinjection. Microinjection of IP(3) (50 microM) and cADP-ribose (cADPr, 50 microM), specific ligands for the IP(3)R and RyR, respectively, demonstrated mobilization of intracellular Ca(2+) stores. Perfusion with cinnarizine (50 microM) or dantrolene (10 microM), antagonists of the IP(3)R and RyR, respectively, eliminated the Ca(2+) response to microinjected IP(3) and cADPr. Superfusion of the neurons with 100 microM ATP, an IP(3)-mediated Ca(2+)-mobilizing agonist, caused intracellular Ca(2+) increments, which were antagonized by cinnarizine, and the RyR antagonists dantrolene, procaine (5 mM), and ryanodine (1 microM). Caffeine (10 mM) was applied repetitively in Ca(2+)-free conditions to deplete RyR-sensitive stores; subsequent perfusion with ATP demonstrated a Ca(2+) response. Conversely, caffeine caused a Ca(2+) response after repetitive ATP exposures. The internal Ca(2+) stores of myenteric neurons are governed by two receptor subtypes, IP(3)R and RyR, which share partial functional overlap. (+info)Effect of dipfluzine on L-type calcium current in guinea pig ventricular myocytes. (2/49)
AIM: To study the effect of dipfluzine (Dip) on L-type calcium current in guinea pig ventricular myocytes. METHODS: Single myocytes were dissociated by enzymatic dissociation method. The current was recorded with the whole-cell configuration of the patch-clamp technique. RESULTS: Dip (0.3 - 30 micromol/L) reduced the voltage-dependently activated peak value of I(Ca-L) in a concentration-dependent manner. The characteristics of I-V relationship were not greatly altered by Dip, and the maximal activation voltage of I(Ca-L) in the presence of Dip was not different from that of control. Steady-state activation of I(Ca-L) was not affected markedly, and the half activation potential V(0.5)) and the slope factor (kappa) in the presence of Dip 3 micromol/L were not markedly different from those of the control. V(0.5) value was (-12.8 +/- 1.7) mV in the control and (-13.2 +/- 2.4) mV in the presence of Dip 3 micromol/L. The kappa value was (7.1 +/- 0.4) mV in the control and (7.5 +/- 0.5) mV in the presence of Dip 3 micromol/L (n = 7 cells from 3 hearts, P > 0.05). Dip 3 micromol/L markedly shifted the steady-state inactivation curve of I(Ca-L) to the left, and accelerated the voltage-dependent steady-state inactivation of calcium current. V(0.5) value was (-19.7 +/- 2.4) mV in the control and (-31 +/- 6) mV in the presence of Dip 3 micromol/L. The kappa value was (3.6 +/- 0.3) mV in the control and (1.8 +/- 0.2) mV in the presence of Dip 3 micromol/L (n = 4 cells from 2 hearts, P < 0.05). Dip 3 micromol/L markedly delayed half-recovery time of Ca2+ channel from inactivation from (40 +/- 11) to (288 +/- 63) ms (n = 4, P < 0.01). CONCLUSION: Dip mainly acts on the inactivated state of L-type calcium channel, accelerates the inactivation of calcium channel, and slows the recovery of calcium channel from inactivated state in guinea pig ventricular myocytes, through which the I(Ca-L) is inhibited. (+info)Effects of dipfluzine on delayed afterdepolarizations and triggered activity induced by ouabain in guinea pig papillary muscles. (3/49)
AIM: To investigate the effects of dipfluzine (Dip) on delayed afterdepolarizations (DADs) and triggered activity (TA) induced by ouabain and high Ca2+ in guinea pig papillary muscles. METHODS: Stable and reproducible DADs and TA in guinea pig papillary muscles were induced by ouabain (1 micromol/L) and high Ca2+ (5.4 mmol/L). DADs and TA were recorded using intracellular glass microelectrode technique. RESULTS: (1) DADs and TA were markedly inhibited by pretreatment with Dip (10, 30 micromol/L). The amplitude and duration of DADs were reduced by Dip (30 micromol/L) from 10.5 mV +/- 2.2 mV and 230 ms +/- 19 ms to 3.6 mV +/- 0.3 mV and 152 ms +/- 14 ms, respectively, and the induced time of DADs was prolonged from (21+/-5) to (66+/-11) min. TA was not observed. (2) Dip (10, 30 micromol/L) had significant therapeutic effects on DADs and TA. The amplitude and duration of DADs were reduced by Dip (30 micromol/L) from 10.4 mV +/- 1.2 mV and 218 ms +/- 22 ms to 3.3 mV +/- 0.6 mV and 159 ms+/-26 ms. The occurrence of TA was also abolished. CONCLUSION: Dip has inhibitory effects on DADs and TA induced by ouabain and high Ca2+ in guinea pig papillary muscles, which might be related to alleviation of intracellular calcium overload through inhibiting calcium channel and/or calcium release from sarcoplasmic reticulum. The effects of Dip on DADs and TA might produce anti-arrhythmic effects. (+info)Parkinsonism and other movement disorders in outpatients in chronic use of cinnarizine and flunarizine. (4/49)
The purpose of this study is to determine the prevalence and the patterns of movement disorders (MD) in outpatients submitted to the chronic use of cinnarizine (cz) or flunarizine (fz), and to establish the main risk factors for MD development. Over a period of 3 months, data were collected from outpatients who were chronic users of cz or fz in a municipal health institute. A total of 26 outpatients were included and all of them were submitted to a protocol that included DSM-4 diagnosis criteria for drug-induced movement disorders, parkinsonism (PK) and depression. Parkinsonism was diagnosed in 34% of the patients, PK plus akathisia, PK plus akathisia and bucco-linguo-masticatory syndrome (BLMS), isolated BLMS and dystonia were found in 4% patients each. Patients with BLMS had the highest median age and the longest average period in which they used the drugs. The affected group, when compared to the non-affected one, presented with higher rates of depression. This study demonstrates the existence of a direct relationship between the time of use of cz and fz, the age and the prevalence of PK and other MD. It also suggests that these drugs increase the incidence of depression. (+info)Pediatric cinnarizine overdose and toxicokinetics. (5/49)
Cinnarizine, a piperazine derivative, is a widely prescribed medication for the treatment of vestibular disorders and motion sickness. Cinnarizine has antihistaminic, antiserotoninergic, antidopaminergic, and calcium channel-blocking properties. We present the first report in the English literature of cinnarizine poisoning and toxicokinetics. A 30-month-old toddler ingested 225 mg of cinnarizine, 18 times the recommended dose for older children. Four hours later, she became jittery with a wide-based gait and vomited 3 times. She was examined by her family physician, who reported stupor and twitching in both hands. On admission to the hospital, 6 hours after the ingestion, she was stuporous and had 3 short, generalized tonic-clonic convulsions that were controlled with a single dose of midazolam. Full clinical recovery was seen 10 hours after ingestion. Serum cinnarizine levels were 7407, 2629, and 711 ng/mL on admission and at 4 and 12 hours thereafter, respectively, 26.9 times higher than the therapeutic levels in adults. Elimination rate constant, calculated by linear regression of the ln concentrations of the 3 data points, was 0.19. Half-life, calculated from the equation t(1/2) = 0.693/kel, where kel is the elimination rate constant, was 3.65 hours. The manufacturing company revealed that their database contains 23 reports of cinnarizine overdose (adult and children), received between 1972 and 2004. Clinically, these cases reflect mainly symptoms of alterations in consciousness ranging from somnolence to stupor and coma, vomiting, extrapyramidal symptoms, and hypotonia. In a small number of young children, convulsions developed; recovery was uneventful in 4 cases and not reported in 1. The neurologic complication may be explained by the antihistaminic effect of cinnarizine because central nervous system depression and convulsions are known complications of antihistaminic overdose. It is hypothesized that cinnarizine-induced convulsions also are related to the antidopaminergic effect of the drug. Apart from the convulsions, no other adverse effects related to calcium channel-blocking properties, such as bradycardia or hemodynamic instability, were observed. Pediatric patients with cinnarizine overdose need to be observed in a health care facility for potential neurologic complications and be treated symptomatically. The delay to onset of clinical effect should be considered in the observation period. (+info)Optimizing the pharmacological component of integrated balance therapy. (6/49)
Drug treatment is an important option for the treatment of peripheral vestibular diseases. AIM: To identify the drug component associated with optimal integrated balance therapy (IBT) for Menieres disease or other peripheral vestibular disorders. MATERIALS AND METHODS: Analysis of a series of patients with Menieres disease patients or patients with other peripheral vestibular disorders that received IBT involving either no medication or betahistine, cinnarizine, clonazepam, flunarizine or Ginkgo biloba during 120 days. RESULTS: In Menieres disease, significant differences were observed for all drug therapies (60 days) versus no medication; betahistine was significantly more effective than all other drugs at 60 and 120 days. For non-Menieres disorders, significant differences were observed among betahistine, cinnarizine, clonazepam and flunarizine and no medication after 60 days; all drug therapies were significantly more effective than no medication after 120 days; betahistine, cinnarizine or clonazepam were equally effective and betahistine was more effective than flunarizine and EGb 761. All treatment options were well tolerated. CONCLUSIONS: Drug therapies were more effective than no medication in the IBT for patients with Menieres disease or other peripheral vestibular disorders. Betahistine was the most effective medication for patients with Menieres disease and was as effective as cinnarizine and clonazepam for other peripheral vestibular disorders. (+info)Cinnarizine in refractory migraine prophylaxis: efficacy and tolerability. A comparison with sodium valproate. (7/49)
(+info)High-performance liquid chromatographic assay for cinnarizine in human plasma. (8/49)
The high performance liquid chromatography for the determination of cinnarizine in human plasma is described. The procedure involves liquid-liquid extraction followed by reversed phase high-performance chromatographic analysis with fluorometric detection. The method was validated for accuracy, precision, specificity, linearity, sensitivity, recovery, and stability. No endogenous compounds were found to interfere. The absolute extraction recovery of cinnarizine and clocinizine (internal standard) from plasma samples were 97% and 89%, respectively. The linearity was assessed in the range 1-100 ng/mL. The intra-day and inter-day relative standard deviations were less than 10%, and the accuracy of the assay expressed by bias was in the range 0.14-2.37%. The method was proved to be suitable for human pharmacokinetic studies following single oral dose. (+info)Cinnarizine is an antihistamine and calcium channel blocker medication that is primarily used to treat motion sickness and vertigo. It works by blocking histamine H1 receptors in the brain, which helps to reduce the symptoms of motion sickness such as nausea and vomiting. Additionally, cinnarizine can also help to improve blood flow to the inner ear, which may help to alleviate symptoms of vertigo and dizziness.
Cinnarizine is available in various forms, including tablets and syrup, and is typically taken two to three times a day. Common side effects of cinnarizine include drowsiness, dry mouth, and stomach upset. It is important to follow the dosage instructions provided by your healthcare provider, as taking too much cinnarizine can increase the risk of side effects.
It's worth noting that cinnarizine is not approved for use in the United States, but it is available in other countries around the world. As with any medication, it's important to consult with your healthcare provider before taking cinnarizine or any other new medication.
Flunarizine is a medication that belongs to the class of drugs known as calcium channel blockers. It is primarily used in the prevention of migraine headaches and to treat vertigo (a spinning sensation) associated with various conditions such as Meniere's disease. Flunarizine works by blocking calcium channels, which reduces the influx of calcium ions into cells. This action leads to relaxation of smooth muscle, decreased neurotransmitter release, and inhibition of platelet aggregation, ultimately helping to prevent migraines and alleviate symptoms of vertigo. It is available in the form of tablets for oral administration.
Bencyclane is a muscle relaxant and antispasmodic medication. It is not a commonly used drug and may be difficult to find in many countries. It works by blocking the action of certain chemicals in the body that can cause smooth muscle spasms, which can lead to various symptoms such as abdominal pain or cramping, urinary frequency or urgency, and other related conditions.
Bencyclane is available in various forms, including tablets and suppositories, and is typically prescribed for short-term use due to its potential for side effects, which can include dizziness, drowsiness, dry mouth, and blurred vision. It should be used with caution and under the supervision of a healthcare provider, as it may interact with other medications and medical conditions.
It is important to note that while I strive to provide accurate and up-to-date information, this definition may not be completely comprehensive or current. Therefore, it is always best to consult with a healthcare professional for medical advice.
Prenylamine is not a medical term in and of itself, but it is the chemical name for a medication that is sometimes used in the medical field. The drug is known as Phenelzine sulfate in its brand name form, with trade names including Nardil.
Phenelzine sulfate (Prenylamine) is a type of medication called a monoamine oxidase inhibitor (MAOI). It works by blocking the action of an enzyme called monoamine oxidase, which helps break down certain chemicals in the brain called neurotransmitters. By blocking this enzyme's action, phenelzine sulfate increases the levels of these neurotransmitters in the brain, which can help to improve mood and alleviate symptoms of depression.
Phenelzine sulfate is used primarily to treat depression that has not responded to other treatments. It may also be used off-label for other conditions, such as anxiety disorders or panic attacks. However, it is important to note that phenelzine sulfate can have serious side effects and interactions with certain foods and medications, so it should only be taken under the close supervision of a healthcare provider.
Calcium channel blockers (CCBs) are a class of medications that work by inhibiting the influx of calcium ions into cardiac and smooth muscle cells. This action leads to relaxation of the muscles, particularly in the blood vessels, resulting in decreased peripheral resistance and reduced blood pressure. Calcium channel blockers also have anti-arrhythmic effects and are used in the management of various cardiovascular conditions such as hypertension, angina, and certain types of arrhythmias.
Calcium channel blockers can be further classified into two main categories based on their chemical structure: dihydropyridines (e.g., nifedipine, amlodipine) and non-dihydropyridines (e.g., verapamil, diltiazem). Dihydropyridines are more selective for vascular smooth muscle and have a greater effect on blood pressure than heart rate or conduction. Non-dihydropyridines have a more significant impact on cardiac conduction and contractility, in addition to their vasodilatory effects.
It is important to note that calcium channel blockers may interact with other medications and should be used under the guidance of a healthcare professional. Potential side effects include dizziness, headache, constipation, and peripheral edema.
"Home accidents" is a general term that refers to unplanned events or mishaps that occur in the home environment, which may result in injury or illness. These types of accidents can happen in various areas of the home, such as the kitchen, bathroom, living room, or bedroom, and can be caused by a range of factors, including:
* Slips, trips, and falls on wet floors, uneven surfaces, or cluttered walkways
* Burns or scalds from hot stoves, ovens, or water
* Cuts or lacerations from sharp objects like knives or broken glass
* Poisoning from ingesting harmful substances like cleaning products or medications
* Strains or sprains from lifting heavy objects or performing repetitive movements
* Drowning in bathtubs, swimming pools, or other bodies of water within the home
Preventing home accidents involves identifying potential hazards and taking steps to minimize or eliminate them. This may include keeping walkways clear, using non-slip mats, properly storing sharp objects and harmful substances, installing safety devices like grab bars and railings, and ensuring that the home is well-lit and ventilated. Regular safety inspections and maintenance can also help prevent home accidents and keep the living environment safe and healthy.
A coma is a deep state of unconsciousness in which an individual cannot be awakened, cannot respond to stimuli, and does not exhibit any sleep-wake cycles. It is typically caused by severe brain injury, illness, or toxic exposure that impairs the function of the brainstem and cerebral cortex.
In a coma, the person may appear to be asleep, but they are not aware of their surroundings or able to communicate or respond to stimuli. Comas can last for varying lengths of time, from days to weeks or even months, and some people may emerge from a coma with varying degrees of brain function and disability.
Medical professionals use various diagnostic tools and assessments to evaluate the level of consciousness and brain function in individuals who are in a coma, including the Glasgow Coma Scale (GCS), which measures eye opening, verbal response, and motor response. Treatment for coma typically involves supportive care to maintain vital functions, manage any underlying medical conditions, and prevent further complications.
Cinnarizine
Cyclizine
Parkinsonism
Flunarizine
Hydroamination
Motion sickness
Benzylamine
Hydroxyzine
Cogan syndrome
Labyrinthitis
Angioedema
Dopamine receptor D2
Mesoporous magnesium carbonate
Over-the-counter drug
Benzhydryl compounds
Antiemetic
List of MeSH codes (D03)
FIASMA
List of drugs: Ci
Piperazine
Serotonin receptor antagonist
Phenazepam
Institute of Naval Medicine
ATC code N07
Antihistamine
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Stugeron2
- Cinnarizine (Stugeron) is an antihistamine (not marketed in the US), that is reported to be effective if administered at a 50mg oral dose before a rough voyage. (bestofinternet.blog)
- Marketed in the U.K. as Stugeron, "Cinnarizine is used to treat problems affecting the inner ear and balance, such as dizziness and sickness (nausea). (stackexchange.com)
Tablets10
- IKCINZ-D is a combination of two medicines: Domperidone and Cinnarizine Tablets which is used in the treatment of vertigo. (neuraclelife.com)
- Before taking Cinnarizine and Domperidone Tablets, inform the doctor if the patient is pregnant, planning pregnancy, or breastfeeding. (neuraclelife.com)
- Domperidone and Cinnarizine Tablets are taken without food in a dose and duration as advised by the doctor. (neuraclelife.com)
- Nausea, dryness in the mouth, indigestion, and weight gain are the most common side effects of Domperidone and Cinnarizine Tablets. (neuraclelife.com)
- Neuracle Lifesciences is an ISO Certified Pharmaceutical company which is also famous as the best Cinnarizine and Domperidone Tablets Manufacturer and Supplier. (neuraclelife.com)
- We also give our Neuropsychiatry PCD Franchise for Cinnarizine and Domperidone Tablets all over the nation. (neuraclelife.com)
- What Are Cinnarizine 15Mg Tablets For? (bestofinternet.blog)
- How Long Does It Take For Cinnarizine Tablets To Work? (bestofinternet.blog)
- Cinnarizine 25 mg (50 tablets) [BEST PRICE] Buy Online at Sopharma Shop! (sopharmashop.com)
- Generic CINNARIZINE + DOMPERIDONE / Brand STUGIL 15 mg + 20 mg Tablets is used to treat Vertigo. (911globalmeds.com)
Antihistamine2
- Cinnarizine is an antihistamine and calcium channel blocker of the diphenylmethylpiperazine group. (wikipedia.org)
- Motor1 and 2 significantly increased the solubility of drugs from many different therapeutic fields, such as paclitaxel (anticancer), cinnarizine (antihistamine), and 17a-ethynyl estradiol (hormone). (umd.edu)
Tablet2
- Cinnarizine tablet belongs to a calcium channel antagonist medicine that works by stopping constriction of the blood vessels of the inner ear and helps in the microcirculation of the ear. (neuraclelife.com)
- The active substance is cinnarizine 25 mg in one tablet. (sopharmashop.com)
Domperidone1
- Branded Drug for Cinnarizine + Domperidone. (911globalmeds.com)
Antiemetic2
- Cinnarizine is an antiemetic agent. (bestofinternet.blog)
- Another calcium channel blocker and antiemetic, cinnarizine, is being explored as a potential vertigo therapy as well. (lifeextension.com)
Make You Sleepy1
- Does Cinnarizine Make You Sleepy? (bestofinternet.blog)
Vertigo5
- Cinnarizine is predominantly used to treat nausea and vomiting associated with motion sickness, vertigo, Ménière's disease, or Cogan's syndrome. (wikipedia.org)
- When prescribed for balance problems and vertigo, cinnarizine is typically taken two or three times daily depending on the amount of each dose and when used to treat motion sickness, the pill is taken at least two hours before travelling and then again every four hours during travel. (wikipedia.org)
- Beyond an anti-vertigo treatment, cinnarizine could be also viewed as a nootropic drug because of its vasorelaxating abilities (due to calcium channel blockade), which happen mostly in brain and the fact that it is also used as a labyrinthine sedative. (wikipedia.org)
- Find out how cinnarizine treats travel sickness, vertigo, tinnitus and Ménière's disease, and how to take it. (www.nhs.uk)
- Cinnarizine is used for the control of vestibular disorders such as vertigo, tinnitus, nausea and vomiting such as that seen in Meniere's disease. (bestofinternet.blog)
Flunarizine1
- An animal study comparing the effectiveness of cinnarizine and flunarizine (a derivative of cinnarizine that is 2.5-15 times stronger for treatment of transient global cerebral ischemia), it was found that cinnarizine helped to improve the functional abnormalities of ischemia, but did not help with damage to the neurons. (wikipedia.org)
Motion sickness1
- Cinnarizine is also effective in the control of motion sickness. (bestofinternet.blog)
Betahistine3
- What Is The Difference Between Cinnarizine And Betahistine? (bestofinternet.blog)
- Betahistine or Cinnarizine for treatment of Meniere's disease. (bestofinternet.blog)
- Betahistine is the analogue of histamine with weaker agonistic effect on histamine H1 receptors and stronger effect on histamine H3 receptors, while Cinnarizine has more effective effect on H1 receptors. (bestofinternet.blog)
Cetirizine1
- Is Cinnarizine The Same As Cetirizine? (bestofinternet.blog)
Antihistamines1
- Antihistamines , such as cinnarizine and cyclizine, can also help. (theconversation.com)
Calcium2
- Cinnarizine inhibits the flow of calcium into red blood cells, which increases the elasticity of the cell wall, thereby increasing their flexibility and making the blood less viscous. (wikipedia.org)
- Cinnarizine is a drug from the group of calcium blockers, used in vestibular disorders, helping the brain and peripheral microcirculation. (sopharmashop.com)
Doses1
- Extraliramid symptoms (tremor, disorientation, imbalance), including Parkinson's syndrome (tremor, slowness of movement and increased muscle tone), dry mouth may occur in older people taking long-term cinnarizine at higher doses. (sopharmashop.com)
Medication1
- There is also evidence that cinnarizine may be used as an effective anti-asthma medication when taken regularly. (wikipedia.org)
Medicines1
- Like all medicines, Cinnarizine Sopharma can cause side effects, although not everybody gets them. (sopharmashop.com)
Mild1
- Side effects experienced while taking cinnarizine range from the mild to the quite severe. (wikipedia.org)
Singapore1
- CINNARIZINE is a active ingredients of medications in Singapore. (shimclinic.com)
Adverse1
- However, a recent 2012 study comparing the effects of cinnarizine to transdermal scopolamine for the treatment of seasickness, concluded that scopolamine was reported as significantly more effective and as having fewer adverse side effects than cinnarizine. (wikipedia.org)
Drug1
- Another drug is cinnarizine (brand name Stugerone), an anti-histamine first tried on airline pilots. (bestofinternet.blog)
Treatment1
- Cinnarizine has also been found to be a valuable second-line treatment for idiopathic urticarial vasculitis. (wikipedia.org)
Standards1
- Home / Pharmaceutical Impurity Standards / Cinnarizine / Cinnarizine Imp. (analyticachemie.in)
Risk3
- Additionally, cinnarizine can be used in scuba divers without an increased risk of central nervous system oxygen toxicity which can result in seizures, and is a high risk in closed-circuit oxygen diving. (wikipedia.org)
- This is also relevant to divers who could potentially have to undergo hypobaric decompression therapy, which uses high oxygen pressure and could also be affected by any cinnarizine-induced CNS oxygen toxicity risk. (wikipedia.org)
- However, cinnarizine does not heighten toxicity risk, and in fact, evidence even seems to suggest that cinnarizine may be beneficial in helping delay O2 toxicity in the central nervous system. (wikipedia.org)
Dimenhydrinate1
- Compared with betahistine, the effects of the fixed combination were not only significantly greater but also more rapid in onset, which might be explained by the joint actions of the two compounds within the fixed combination, i.e. the short-term effects of cinnarizine on calcium ion flux in the vestibulum and its long-term effects on cerebral vasculature, and the effects of dimenhydrinate in the brainstem. (medscape.com)
Effects of cinnarizine1
- However, a recent 2012 study comparing the effects of cinnarizine to transdermal scopolamine for the treatment of seasickness, concluded that scopolamine was reported as significantly more effective and as having fewer adverse side effects than cinnarizine. (wikipedia.org)
Active Ingredient2
- After much experimentation I now use Stugeron, a children's motion-sickness tablet which has cinnarizine as an active ingredient. (goodoldboat.com)
- The active ingredient present in sturgeon is cinnarizine. (drseemabshaikh.com)
Tablet1
- The two active components of the fixed combination - cinnarizine (20mg per tablet) and dimen- hydrinate (40mg per tablet) - have distinct pharmacological properties that complement one another synergistically. (medscape.com)
Parkinson's2
- Aggravation of Parkinson's disease by cinnarizine. (nih.gov)
- Cinnarizine can aggravate symptoms in patients with Parkinson's disease. (drseemabshaikh.com)
Efficacy1
- 8. In vitro efficacy of cinnarizine against lymphoma and multiple myeloma. (nih.gov)
Migraine1
- Expert opinion recommends that cinnarizine not be used in migraine prophylaxis in nursing mothers. (nih.gov)
Nanoparticles1
- However, there were substantial differences between the dissolution curves of the nanoparticles as fenofibrate exhibited supersaturation followed by precipitation, whereas cinnarizine did not exhibit any supersaturation, but instead a shift towards faster dissolution rate. (bvsalud.org)
Symptoms2
- Although Stugeron (Cinnarizine) is considered to be effective at preventing travel sickness symptoms, in some cases it may cause side effects. (unitedpharmacies-uk.md)
- The captain of the sailboat offered the three sick PJs approximately 18mg of cinnarizine two or three times a day with relief of symptoms and improvement on operational effectiveness. (jsomonline.org)
Derivative1
- Hessel, V. / Continuous-flow multistep synthesis of cinnarizine, cyclizine, and a buclizine derivative from bulk alcohols . (tue.nl)
Medication2
- There is also evidence that cinnarizine may be used as an effective anti-asthma medication when taken regularly. (wikipedia.org)
- We discuss the current theories on motion sickness, the effect of motion sickness on operational effectiveness, and research on treatment of motion sickness, including the medication cinnarizine. (jsomonline.org)
Drugs2
- Cinnarizine should not be given along with other drugs which cause sedation. (drseemabshaikh.com)
- Two examples of poorly soluble drugs were examined (cinnarizine and fenofibrate). (bvsalud.org)
Price1
- Buy Cinnarizine EP Impurity D from GLP Pharma Standards at best competitive price. (glppharmastandards.com)
Terms1
- Cinnarizine, cyclizine, buclizine, and meclizine belong to a family of antihistamines that resemble each other in terms of a 1-diphenylmethylpiperazine moiety. (tue.nl)
Discount1
- Purchasing discount Stutgeron (Cinnarizine) online via Prescription Europe is simple and convenient. (prescription-europe.com)
Side1
- Side effects experienced while taking cinnarizine range from the mild to the quite severe. (wikipedia.org)
Therapy1
- This is also relevant to divers who could potentially have to undergo hypobaric decompression therapy, which uses high oxygen pressure and could also be affected by any cinnarizine-induced CNS oxygen toxicity risk. (wikipedia.org)
Blood1
- In addition, like betahistine, cinnarizine has been shown to increase blood flow in compromised intra- and extracranial areas. (medscape.com)