Type species of CHLAMYDIA causing a variety of ocular and urogenital diseases.
Infections with bacteria of the genus CHLAMYDIA.
A genus of the family CHLAMYDIACEAE whose species cause a variety of diseases in vertebrates including humans, mice, and swine. Chlamydia species are gram-negative and produce glycogen. The type species is CHLAMYDIA TRACHOMATIS.
Subacute inflammation of the inguinal lymph glands caused by certain immunotypes of CHLAMYDIA TRACHOMATIS. It is a sexually transmitted disease in the U.S. but is more widespread in developing countries. It is distinguished from granuloma venereum (see GRANULOMA INGUINALE), which is caused by Calymmatobacterium granulomatis.
Pathological processes of the female URINARY TRACT and the reproductive system (GENITALIA, FEMALE).
Pathological processes involving the female reproductive tract (GENITALIA, FEMALE).
Pathological processes of the male URINARY TRACT and the reproductive system (GENITALIA, MALE).
Inflammation of the UTERINE CERVIX.
Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879.
The neck portion of the UTERUS between the lower isthmus and the VAGINA forming the cervical canal.
A chronic infection of the CONJUNCTIVA and CORNEA caused by CHLAMYDIA TRACHOMATIS.
A genus of CHLAMYDOPHILA infecting primarily birds. It contains eight known serovars, some of which infect more than one type of host, including humans.
A spectrum of inflammation involving the female upper genital tract and the supporting tissues. It is usually caused by an ascending infection of organisms from the endocervix. Infection may be confined to the uterus (ENDOMETRITIS), the FALLOPIAN TUBES; (SALPINGITIS); the ovaries (OOPHORITIS), the supporting ligaments (PARAMETRITIS), or may involve several of the above uterine appendages. Such inflammation can lead to functional impairment and infertility.
A tube that transports URINE from the URINARY BLADDER to the outside of the body in both the sexes. It also has a reproductive function in the male by providing a passage for SPERM.
Species of CHLAMYDIA causing pneumonitis in mice and hamsters. These isolates formerly belonged to CHLAMYDIA TRACHOMATIS.
Inflammation of the uterine salpinx, the trumpet-shaped FALLOPIAN TUBES, usually caused by ascending infections of organisms from the lower reproductive tract. Salpingitis can lead to tubal scarring, hydrosalpinx, tubal occlusion, INFERTILITY, and ectopic pregnancy (PREGNANCY, ECTOPIC)
Inflammation involving the URETHRA. Similar to CYSTITIS, clinical symptoms range from vague discomfort to painful urination (DYSURIA), urethral discharge, or both.
Bacterial diseases transmitted or propagated by sexual conduct.
A species of gram-negative, aerobic bacteria primarily found in purulent venereal discharges. It is the causative agent of GONORRHEA.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Pathological processes of the UTERINE CERVIX.
Proteins isolated from the outer membrane of Gram-negative bacteria.
A form of fluorescent antibody technique utilizing a fluorochrome conjugated to an antibody, which is added directly to a tissue or cell suspension for the detection of a specific antigen. (Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
Liquid by-product of excretion produced in the kidneys, temporarily stored in the bladder until discharge through the URETHRA.
An infection of the eyes characterized by the presence in conjunctival epithelial cells of inclusion bodies indistinguishable from those of trachoma. It is acquired by infants during birth and by adults from swimming pools. The etiological agent is CHLAMYDIA TRACHOMATIS whose natural habitat appears to be the genito-urinary tract. Inclusion conjunctivitis is a less severe disease than trachoma and usually clears up spontaneously.
A generic term for any circumscribed mass of foreign (e.g., lead or viruses) or metabolically inactive materials (e.g., ceroid or MALLORY BODIES), within the cytoplasm or nucleus of a cell. Inclusion bodies are in cells infected with certain filtrable viruses, observed especially in nerve, epithelial, or endothelial cells. (Stedman, 25th ed)
Laboratory techniques that involve the in-vitro synthesis of many copies of DNA or RNA from one original template.
Pathological processes involving the URETHRA.
Porins are protein molecules that were originally found in the outer membrane of GRAM-NEGATIVE BACTERIA and that form multi-meric channels for the passive DIFFUSION of WATER; IONS; or other small molecules. Porins are present in bacterial CELL WALLS, as well as in plant, fungal, mammalian and other vertebrate CELL MEMBRANES and MITOCHONDRIAL MEMBRANES.
A DNA amplification technique based upon the ligation of OLIGONUCLEOTIDE PROBES. The probes are designed to exactly match two adjacent sequences of a specific target DNA. The chain reaction is repeated in three steps in the presence of excess probe: (1) heat denaturation of double-stranded DNA, (2) annealing of probes to target DNA, and (3) joining of the probes by thermostable DNA ligase. After the reaction is repeated for 20-30 cycles the production of ligated probe is measured.
Procedures for collecting, preserving, and transporting of specimens sufficiently stable to provide accurate and precise results suitable for clinical interpretation.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.
Techniques used in studying bacteria.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
Pathological processes of the VAGINA.
An aseptic, inflammatory arthritis developing secondary to a primary extra-articular infection, most typically of the GASTROINTESTINAL TRACT or UROGENITAL SYSTEM. The initiating trigger pathogens are usually SHIGELLA; SALMONELLA; YERSINIA; CAMPYLOBACTER; or CHLAMYDIA TRACHOMATIS. Reactive arthritis is strongly associated with HLA-B27 ANTIGEN.
Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.
Infections of the genital tract in females or males. They can be caused by endogenous, iatrogenic, or sexually transmitted organisms.
A species of gram-negative bacteria originally isolated from urethral specimens of patients with non-gonoccocal URETHRITIS. In primates it exists in parasitic association with ciliated EPITHELIAL CELLS in the genital and respiratory tracts.
Pathological processes involving the male reproductive tract (GENITALIA, MALE).
Diseases due to or propagated by sexual contact.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
All the organs involved in reproduction and the formation and release of URINE. It includes the kidneys, ureters, BLADDER; URETHRA, and the organs of reproduction - ovaries, UTERUS; FALLOPIAN TUBES; VAGINA; and CLITORIS in women and the testes; SEMINAL VESICLES; PROSTATE; seminal ducts; and PENIS in men.
Substances elaborated by bacteria that have antigenic activity.
Infection with CHLAMYDOPHILA PSITTACI (formerly Chlamydia psittaci), transmitted to humans by inhalation of dust-borne contaminated nasal secretions or excreta of infected BIRDS. This infection results in a febrile illness characterized by PNEUMONITIS and systemic manifestations.
The female reproductive organs. The external organs include the VULVA; BARTHOLIN'S GLANDS; and CLITORIS. The internal organs include the VAGINA; UTERUS; OVARY; and FALLOPIAN TUBES.
A synthetic tetracycline derivative with similar antimicrobial activity.
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
The genital canal in the female, extending from the UTERUS to the VULVA. (Stedman, 25th ed)
Infections with bacteria of the genus CHLAMYDOPHILA.
Diseases involving the FALLOPIAN TUBES including neoplasms (FALLOPIAN TUBE NEOPLASMS); SALPINGITIS; tubo-ovarian abscess; and blockage.
Diminished or absent ability of a female to achieve conception.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
A pair of highly specialized muscular canals extending from the UTERUS to its corresponding OVARY. They provide the means for OVUM collection, and the site for the final maturation of gametes and FERTILIZATION. The fallopian tube consists of an interstitium, an isthmus, an ampulla, an infundibulum, and fimbriae. Its wall consists of three histologic layers: serous, muscular, and an internal mucosal layer lined with both ciliated and secretory cells.
INFLAMMATION of the MUCOUS MEMBRANE of the RECTUM, the distal end of the large intestine (INTESTINE, LARGE).
Infections with species of the genus MYCOPLASMA.
A genus of gram-negative, nonmotile bacteria which are common parasitic inhabitants of the urogenital tracts of humans, cattle, dogs, and monkeys.
A species of TRICHOMONAS that produces a refractory vaginal discharge in females, as well as bladder and urethral infections in males.
Organized periodic procedures performed on large groups of people for the purpose of detecting disease.
Conjunctivitis is an inflammation or infection of the conjunctiva, the transparent membrane that lines the inner surface of the eyelids and covers the white part of the eye, resulting in symptoms such as redness, swelling, itching, burning, discharge, and increased sensitivity to light.
A group I chaperonin protein that forms the barrel-like structure of the chaperonin complex. It is an oligomeric protein with a distinctive structure of fourteen subunits, arranged in two rings of seven subunits each. The protein was originally studied in BACTERIA where it is commonly referred to as GroEL protein.
Studies determining the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. For drugs and devices, CLINICAL TRIALS AS TOPIC; DRUG EVALUATION; and DRUG EVALUATION, PRECLINICAL are available.
Infections with bacteria of the family CHLAMYDIACEAE.
Proteins found in any species of bacterium.
A species of CHLAMYDOPHILA that causes acute respiratory infection, especially atypical pneumonia, in humans, horses, and koalas.
The mucous membrane that covers the posterior surface of the eyelids and the anterior pericorneal surface of the eyeball.
Collection of pooled secretions of the posterior vaginal fornix for cytologic examination.
The co-occurrence of pregnancy and an INFECTION. The infection may precede or follow FERTILIZATION.
A family of gram-negative, coccoid microorganisms, in the order CHLAMYDIALES, pathogenic for vertebrates. Genera include CHLAMYDIA and CHLAMYDOPHILA.
Infections in birds and mammals produced by various species of Trichomonas.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Inflammation of the vagina, marked by a purulent discharge. This disease is caused by the protozoan TRICHOMONAS VAGINALIS.
Purulent infections of the conjunctiva by several species of gram-negative, gram-positive, or acid-fast organisms. Some of the more commonly found genera causing conjunctival infections are Haemophilus, Streptococcus, Neisseria, and Chlamydia.
Substances that reduce the growth or reproduction of BACTERIA.
Sexual activities of humans.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Used as a support for ion-exchange chromatography.
A common inhabitant of the vagina and cervix and a potential human pathogen, causing infections of the male and female reproductive tracts. It has also been associated with respiratory disease and pharyngitis. (From Dorland, 28th ed)
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Infections with bacteria of the order MYCOPLASMATALES.
Identification of those persons (or animals) who have had such an association with an infected person, animal, or contaminated environment as to have had the opportunity to acquire the infection. Contact tracing is a generally accepted method for the control of sexually transmitted diseases.
Suspensions of attenuated or killed bacteria administered for the prevention or treatment of infectious bacterial disease.
The external and internal organs related to reproduction.
A clear or white discharge from the VAGINA, consisting mainly of MUCUS.
Process of determining and distinguishing species of bacteria or viruses based on antigens they share.
The practice of indulging in sexual relations for money.
Pathological developments in the RECTUM region of the large intestine (INTESTINE, LARGE).
Pathological processes involving the PHARYNX.
Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.
Acute conjunctival inflammation in the newborn, usually caused by maternal gonococcal infection. The causative agent is NEISSERIA GONORRHOEAE. The baby's eyes are contaminated during passage through the birth canal.
A potentially life-threatening condition in which EMBRYO IMPLANTATION occurs outside the cavity of the UTERUS. Most ectopic pregnancies (>96%) occur in the FALLOPIAN TUBES, known as TUBAL PREGNANCY. They can be in other locations, such as UTERINE CERVIX; OVARY; and abdominal cavity (PREGNANCY, ABDOMINAL).
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A common gynecologic disorder characterized by an abnormal, nonbloody discharge from the genital tract.
Inflammation of the EPIDIDYMIS. Its clinical features include enlarged epididymis, a swollen SCROTUM; PAIN; PYURIA; and FEVER. It is usually related to infections in the URINARY TRACT, which likely spread to the EPIDIDYMIS through either the VAS DEFERENS or the lymphatics of the SPERMATIC CORD.
A republic in western Africa, constituting an enclave within SENEGAL extending on both sides of the Gambia River. Its capital is Banjul, formerly Bathurst.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
The presence of bacteria in the urine which is normally bacteria-free. These bacteria are from the URINARY TRACT and are not contaminants of the surrounding tissues. Bacteriuria can be symptomatic or asymptomatic. Significant bacteriuria is an indicator of urinary tract infection.
A species of gram-negative bacteria found in the human genitourinary tract (UROGENITAL SYSTEM), oropharynx, and anal canal. Serovars 1, 3, 6, and 14 have been reclassed into a separate species UREAPLASMA parvum.
Married or single individuals who share sexual relations.
Pneumonia caused by infections with the genus CHLAMYDIA; and CHLAMYDOPHILA, usually with CHLAMYDOPHILA PNEUMONIAE.
The functional hereditary units of BACTERIA.
Polymicrobial, nonspecific vaginitis associated with positive cultures of Gardnerella vaginalis and other anaerobic organisms and a decrease in lactobacilli. It remains unclear whether the initial pathogenic event is caused by the growth of anaerobes or a primary decrease in lactobacilli.
Negative test results in subjects who possess the attribute for which the test is conducted. The labeling of diseased persons as healthy when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)
Infections with bacteria of the genus UREAPLASMA.
A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms.
A genus of the family CHLAMYDIACEAE comprising gram-negative non CHLAMYDIA TRACHOMATIS-like species infecting vertebrates. Chlamydophila do not produce detectable quantities of glycogen. The type species is CHLAMYDOPHILA PSITTACI.
A branch of medicine which deals with sexually transmitted disease.
Individuals requesting induced abortions.
MOLECULAR BIOLOGY techniques used in the diagnosis of disease.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Those facilities which administer health services to individuals who do not require hospitalization or institutionalization.
A slightly alkaline secretion of the endocervical glands. The consistency and amount are dependent on the physiological hormone changes in the menstrual cycle. It contains the glycoprotein mucin, amino acids, sugar, enzymes, and electrolytes, with a water content up to 90%. The mucus is a useful protection against the ascent of bacteria and sperm into the uterus. (From Dictionary of Obstetrics and Gynecology, 1988)
Ribonucleic acid in bacteria having regulatory and catalytic roles as well as involvement in protein synthesis.

Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages. (1/2917)

Both chlamydial and human heat shock protein 60s (HSP 60), which colocalize in human atheroma, may contribute to inflammation during atherogenesis. We tested the hypothesis that chlamydial or human HSP 60 activates human endothelial cells (ECs), smooth muscle cells (SMCs), and monocyte-derived macrophages. We examined the expression of adhesion molecules such as endothelial-leukocyte adhesion molecule-1 (E-selectin), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1), and the production of the proinflammatory cytokine interleukin-6 (IL-6). We also tested whether either HSP 60 induces nuclear factor-kappaB (NF-kappaB), which contributes to the gene expression of these molecules. Either chlamydial or human HSP 60 induced E-selectin, ICAM-1, and VCAM-1 expression on ECs similar to levels induced by Escherichia coli lipopolysaccharide (LPS). Each HSP 60 also significantly induced IL-6 production by ECs, SMCs, and macrophages to an extent similar to that induced by E. coli LPS, as assessed by enzyme-linked immunosorbent assay (ELISA). In ECs, either HSP 60 triggered activation of NF-kappaB complexes containing p65 and p50 Rel proteins. Heat treatment abolished all these effects, but did not alter the ability of E. coli LPS to induce these functions. Chlamydial and human HSP 60s therefore activate human vascular cell functions relevant to atherogenesis and lesional complications. These findings help to elucidate the mechanisms by which a chronic asymptomatic chlamydial infection might contribute to the pathophysiology of atheroma.  (+info)

Clearance of Chlamydia trachomatis from the murine genital mucosa does not require perforin-mediated cytolysis or Fas-mediated apoptosis. (2/2917)

The molecular mechanisms of resistance to genital infection with the mouse pneumonitis (MoPn) strain of Chlamydia trachomatis are unknown. A role for major histocompatibility complex class II-restricted, interleukin-12-dependent CD4(+) T cells has been established, but the functional activity of these cells does not depend on secretion of gamma interferon. Here we examined the potential contribution of T-cell-mediated cytotoxicity and apoptosis to mucosal clearance of MoPn by using mice deficient in the molecular mediators of target cell lysis. Animals lacking perforin, Fas, Fas ligand, or both perforin and Fas ligand were infected genitally with C. trachomatis MoPn and monitored for expression of immunity to chlamydial antigens and clearance of MoPn from the genital mucosa. In each case, the profile of spleen cytokine production, the magnitude of the host antibody response, and the kinetics of chlamydial clearance were similar to those of genetically intact controls. Compensatory overproduction of tumor necrosis factor alpha, an alternate mediator of apoptosis in certain cell types, did not appear to account for the ability of mutant mice to resolve Chlamydia infections. These results fail to support CD4(+) T-cell-mediated apoptosis or CD8(+) T-cell-mediated cytotoxicity as being critical to the clearance of C. trachomatis MoPn urogenital infections.  (+info)

Nongonococcal urethritis--a new paradigm. (3/2917)

Urethritis in men has been categorized historically as gonococcal or nongonococcal (NGU). The major pathogens causing NGU are Chlamydia trachomatis and Ureaplasma urealyticum. Trichomonas vaginalis may be involved occasionally. In up to one-half of cases, an etiologic organism may not be identified. In this review we present recent advances in the diagnosis and management of NGU and discuss how they may be applied in a variety of clinical settings, including specialized STD clinics and primary health care practices. In particular, the development of the noninvasive urine-based nucleic acid amplification tests may warrant rethinking of the traditional classification of urethritis as gonococcal urethritis or NGU. Diagnostic for Chlamydia are strongly recommended because etiologic diagnosis of chlamydial urethritis may have important public health implications, such as the need for partner referral and reporting. A single 1-g dose of azithromycin was found to be therapeutically equivalent to the tetracyclines and may offer the advantage of better compliance.  (+info)

Chlamydia infections and heart disease linked through antigenic mimicry. (4/2917)

Chlamydia infections are epidemiologically linked to human heart disease. A peptide from the murine heart muscle-specific alpha myosin heavy chain that has sequence homology to the 60-kilodalton cysteine-rich outer membrane proteins of Chlamydia pneumoniae, C. psittaci, and C. trachomatis was shown to induce autoimmune inflammatory heart disease in mice. Injection of the homologous Chlamydia peptides into mice also induced perivascular inflammation, fibrotic changes, and blood vessel occlusion in the heart, as well as triggering T and B cell reactivity to the homologous endogenous heart muscle-specific peptide. Chlamydia DNA functioned as an adjuvant in the triggering of peptide-induced inflammatory heart disease. Infection with C. trachomatis led to the production of autoantibodies to heart muscle-specific epitopes. Thus, Chlamydia-mediated heart disease is induced by antigenic mimicry of a heart muscle-specific protein.  (+info)

Persistent chlamydial envelope antigens in antibiotic-exposed infected cells trigger neutrophil chemotaxis. (5/2917)

An in vitro coculture model system was used to explore conditions that trigger neutrophil chemotaxis to Chlamydia trachomatis infected human epithelial cells (HEC-1B). Polarized HEC-1B monolayers growing on extracellular matrix (ECM) were infected with C. trachomatis serovar E. By 36 h, coincident with the secretion of chlamydial lipopolysaccharide and major outer membrane protein to the surfaces of infected cells, human polymorphonuclear neutrophils (PMNL) loaded with azithromycin migrated through the ECM and infiltrated the HEC-1B monolayer. Bioreactive azithromycin was delivered by the chemotactic PMNL to infected epithelial cells in concentrations sufficient to kill intracellular chlamydiae. However, residual chlamydial envelopes persisted for 4 weeks, and PMNL chemotaxis was triggered to epithelial cells containing residual envelopes. Infected endometrial cells demonstrated up-regulation of ENA-78 and GCP-2 chemokine mRNA. Thus, despite appropriate antimicrobial therapy, residual chlamydial envelope antigens may persist in infected tissues of culture-negative women and provide one source for sustained inflammation.  (+info)

Mailed, home-obtained urine specimens: a reliable screening approach for detecting asymptomatic Chlamydia trachomatis infections. (6/2917)

The use of mailed, home-obtained urine specimens could facilitate screening programs for the detection of asymptomatic Chlamydia trachomatis infections. Since transport time could have an adverse effect on the sensitivity of C. trachomatis detection by PCR, the influence of DNA degradation on amplification was monitored over the course of 1 week. Therefore, urine specimens were aliquoted on the day of collection or arrival. Two groups of urine specimens were investigated. Group I contains first-void C. trachomatis-positive and -negative urine samples. DNA degradation was monitored in group I samples for 7 days at room temperature (RT) and at 4 degrees C by amplifying different lengths of the human beta-globin gene and the C. trachomatis plasmid target. DNA degradation was observed only for the larger human beta-globin fragments at days 5 to 7 at RT. In contrast, at 4 degrees C all targets could be amplified. Urine specimens were also frozen and thawed before aliquoting to mimic freezing during transport. This resulted in a lower sensitivity for the detection of C. trachomatis after thawing and 3 to 4 days at RT. In addition, mailed, home-obtained C. trachomatis-positive urine specimens (group II) were analyzed for 7 days after arrival by two commercially available C. trachomatis detection systems (PCR and ligase chain reaction [LCR]). The C. trachomatis plasmid target in mailed, home-obtained urine specimens could be amplified by both PCR and LCR after 1 week of storage and/or transport at RT. In conclusion, our findings indicate that mailed, home-obtained urine specimens are suitable for the sensitive detection of asymptomatic C. trachomatis infections by amplification methods, even if the transport time is up to 1 week at RT. These findings support the feasibility and validity of screening programs based on mailed, home-obtained urine specimens. Larger studies should be initiated to confirm our results.  (+info)

Chlamydia trachomatis infections: progress and problems. (7/2917)

Chalmydia trachomatis infections are the most common bacterial sexually transmitted disease in the United States. A substantial proportion of initial infections in both men and women are asymptomatic. Use of nucleic acid amplification-based diagnostic tests on first-void urine makes it possible to initiate community-based screening programs aimed at identifying asymptomatically infected men and women. Directly observed single-dose therapy with azithromycin is now available. Screening programs have been demonstrated to reduce the overall prevalence of chlamydial infection in the tested population and to reduce the incidence of subsequent pelvic inflammatory disease in previously screened women. The sequelae of chlamydial infections are likely due to immunopathologically mediated events in which both the chlamydial 60 kDa heat-shock protein and genetic predisposition of specific patients play a role. An improved understanding of immunologic events leading to upper genital tract scarring is needed to target specific interventions and facilitate development of a vaccine.  (+info)

Immunity to Chlamydia trachomatis mouse pneumonitis induced by vaccination with live organisms correlates with early granulocyte-macrophage colony-stimulating factor and interleukin-12 production and with dendritic cell-like maturation. (8/2917)

As is true for other intracellular pathogens, immunization with live Chlamydia trachomatis generally induces stronger protective immunity than does immunization with inactivated organism. To investigate the basis for such a difference, we studied immune responses in BALB/c mice immunized with viable or UV-killed C. trachomatis mouse pneumonitis (MoPn). Strong, acquired resistance to C. trachomatis infection was elicited by immunization with viable but not dead organisms. Immunization with viable organisms induced high levels of antigen-specific delayed-type hypersensitivity (DTH), gamma interferon production, and immunoglobulin A (IgA) responses. Immunization with inactivated MoPn mainly induced interleukin-10 (IL-10) production and IgG1 antibody without IgA or DTH responses. Analysis of local early cytokine and cellular events at days 3, 5, and 7 after peritoneal cavity immunization showed that high levels of granulocyte-macrophage colony-stimulating factor and IL-12 were detected with viable but not inactivated organisms. Furthermore, enrichment of a dendritic cell (DC)-like population was detected in the peritoneal cavity only among mice immunized with viable organisms. The results suggest that early differences in inducing proinflammatory cytokines and activation and differentiation of DCs may be the key mechanism underlying the difference between viable and inactivated organisms in inducing active immunity to C. trachomatis infection.  (+info)

'Chlamydia trachomatis' is a species of bacterium that is the causative agent of several infectious diseases in humans. It is an obligate intracellular pathogen, meaning it can only survive and reproduce inside host cells. The bacteria are transmitted through sexual contact, and can cause a range of genital tract infections, including urethritis, cervicitis, pelvic inflammatory disease, and epididymitis. In women, chlamydial infection can also lead to serious complications such as ectopic pregnancy and infertility.

In addition to genital infections, 'Chlamydia trachomatis' is also responsible for two other diseases: trachoma and lymphogranuloma venereum (LGV). Trachoma is a leading cause of preventable blindness worldwide, affecting mostly children in developing countries. It is spread through contact with contaminated hands, clothing, or eye secretions. LGV is a sexually transmitted infection that can cause inflammation of the lymph nodes, rectum, and genitals.

'Chlamydia trachomatis' infections are often asymptomatic, making them difficult to diagnose and treat. However, they can be detected through laboratory tests such as nucleic acid amplification tests (NAATs) or culture. Treatment typically involves antibiotics such as azithromycin or doxycycline. Prevention measures include safe sex practices, regular screening for STIs, and good hygiene.

Chlamydia infections are caused by the bacterium Chlamydia trachomatis and can affect multiple body sites, including the genitals, eyes, and respiratory system. The most common type of chlamydia infection is a sexually transmitted infection (STI) that affects the genitals.

In women, chlamydia infections can cause symptoms such as abnormal vaginal discharge, burning during urination, and pain in the lower abdomen. In men, symptoms may include discharge from the penis, painful urination, and testicular pain or swelling. However, many people with chlamydia infections do not experience any symptoms at all.

If left untreated, chlamydia infections can lead to serious complications, such as pelvic inflammatory disease (PID) in women, which can cause infertility and ectopic pregnancy. In men, chlamydia infections can cause epididymitis, an inflammation of the tube that carries sperm from the testicles, which can also lead to infertility.

Chlamydia infections are diagnosed through a variety of tests, including urine tests and swabs taken from the affected area. Once diagnosed, chlamydia infections can be treated with antibiotics such as azithromycin or doxycycline. It is important to note that treatment only clears the infection and does not repair any damage caused by the infection.

Prevention measures include practicing safe sex, getting regular STI screenings, and avoiding sharing towels or other personal items that may come into contact with infected bodily fluids.

Chlamydia is a bacterial infection caused by the species Chlamydia trachomatis. It is one of the most common sexually transmitted infections (STIs) worldwide. The bacteria can infect the genital tract, urinary tract, eyes, and rectum. In women, it can also infect the reproductive organs and cause serious complications such as pelvic inflammatory disease, infertility, and ectopic pregnancy.

Chlamydia is often asymptomatic, especially in women, which makes it easy to spread unknowingly. When symptoms do occur, they may include abnormal vaginal or penile discharge, burning sensation during urination, pain during sexual intercourse, and painful testicular swelling in men. Chlamydia can be diagnosed through a variety of tests, including urine tests and swab samples from the infected site.

The infection is easily treated with antibiotics, but if left untreated, it can lead to serious health complications. It's important to get tested regularly for STIs, especially if you are sexually active with multiple partners or have unprotected sex. Prevention methods include using condoms during sexual activity and practicing good personal hygiene.

Lymphogranuloma venereum (LGV) is a sexually transmitted infection caused by certain strains of the bacterium Chlamydia trachomatis. It primarily affects the lymphatic system, leading to inflammation and swelling of the lymph nodes, particularly in the genital area.

The progression of LGV typically occurs in three stages:
1. Primary stage: A small painless papule or ulcer forms at the site of infection, usually on the genitals, within 3-30 days after exposure. This stage is often asymptomatic and resolves on its own within a few weeks.
2. Secondary stage: Within a few weeks to months after the initial infection, patients may develop painful inguinal or femoral lymphadenopathy (swollen lymph nodes) in the groin area, which can sometimes break open and drain. Other possible symptoms include fever, chills, malaise, headache, and joint pain.
3. Tertiary stage: If left untreated, LGV can lead to chronic complications such as fibrosis (scarring) and strictures of the lymphatic vessels, genital elephantiasis (severe swelling of the genitals), and rectovaginal fistulas (abnormal connections between the rectum and vagina).

LGV is more common in tropical and subtropical regions but has been increasingly reported in industrialized countries, particularly among men who have sex with men. Diagnosis typically involves laboratory testing of fluid from an infected lymph node or a sample from the genital ulcer. Treatment consists of antibiotics such as doxycycline, azithromycin, or erythromycin, which can effectively cure the infection if administered promptly.

Female urogenital diseases refer to a range of medical conditions that affect the female urinary and genital systems. These systems include the kidneys, ureters, bladder, urethra, vulva, vagina, and reproductive organs such as the ovaries and uterus.

Some common female urogenital diseases include:

1. Urinary tract infections (UTIs): These are infections that occur in any part of the urinary system, including the kidneys, ureters, bladder, or urethra.
2. Pelvic inflammatory disease (PID): This is an infection of the reproductive organs, including the uterus, fallopian tubes, and ovaries.
3. Endometriosis: This is a condition in which tissue similar to the lining of the uterus grows outside of the uterus, often on the ovaries, fallopian tubes, or other pelvic structures.
4. Ovarian cysts: These are fluid-filled sacs that form on the ovaries.
5. Uterine fibroids: These are noncancerous growths that develop in the muscular wall of the uterus.
6. Interstitial cystitis/bladder pain syndrome (IC/BPS): This is a chronic bladder condition characterized by pain, pressure, and discomfort in the bladder and pelvic area.
7. Sexually transmitted infections (STIs): These are infections that are passed from person to person during sexual contact. Common STIs include chlamydia, gonorrhea, syphilis, and HIV.
8. Vulvodynia: This is chronic pain or discomfort of the vulva, the external female genital area.
9. Cancers of the reproductive system, such as ovarian cancer, cervical cancer, and uterine cancer.

These are just a few examples of female urogenital diseases. It's important for women to receive regular medical care and screenings to detect and treat these conditions early, when they are often easier to manage and have better outcomes.

Genital diseases in females refer to various medical conditions that affect the female reproductive system, including the vulva, vagina, cervix, uterus, and ovaries. These conditions can be caused by bacterial, viral, or fungal infections, hormonal imbalances, or structural abnormalities. Some common examples of genital diseases in females include bacterial vaginosis, yeast infections, sexually transmitted infections (STIs) such as chlamydia, gonorrhea, and human papillomavirus (HPV), pelvic inflammatory disease (PID), endometriosis, uterine fibroids, ovarian cysts, and vulvar or vaginal cancer. Symptoms of genital diseases in females can vary widely depending on the specific condition but may include abnormal vaginal discharge, pain or discomfort during sex, irregular menstrual bleeding, painful urination, and pelvic pain. It is important for women to receive regular gynecological care and screenings to detect and treat genital diseases early and prevent complications.

"Male urogenital diseases" refer to a range of medical conditions that affect the urinary and reproductive systems in males. This can include:

1. Benign Prostatic Hyperplasia (BPH): An enlarged prostate gland that can cause difficulties with urination.

2. Prostatitis: Inflammation of the prostate gland, which can cause pain, urinary frequency and difficulty, and sexual dysfunction.

3. Erectile Dysfunction (ED): The inability to achieve or maintain an erection sufficient for sexual activity.

4. Peyronie's Disease: A condition where scar tissue causes the penis to bend or curve during an erection.

5. Testicular Cancer: A malignant tumor that develops in the testicle.

6. Epididymitis: Inflammation of the epididymis, a coiled tube at the back of the testicle where sperm matures.

7. Orchitis: Inflammation of the testicle, often caused by an infection.

8. Urinary Tract Infections (UTIs): Bacterial infections that can occur anywhere along the urinary tract.

9. Kidney Stones: Small, hard mineral deposits that form in the kidneys and can cause severe pain when passed.

10. Bladder Cancer: A malignant tumor that develops in the bladder.

These conditions can vary greatly in severity and treatment, so it's important for individuals to seek medical advice if they suspect they may have a urogenital disease.

Uterine cervicitis is a medical condition that refers to the inflammation of the uterine cervix, which is the lower part of the uterus that opens into the vagina. It can be caused by various factors, including bacterial or viral infections, allergies, or irritants. The symptoms of cervicitis may include abnormal vaginal discharge, pain during sexual intercourse, bleeding after sex, and irregular menstrual bleeding. In some cases, cervicitis may not cause any noticeable symptoms. If left untreated, cervicitis can increase the risk of developing more severe complications, such as pelvic inflammatory disease or infertility. Treatment for cervicitis typically involves antibiotics to eliminate any underlying infections and management of symptoms. Regular gynecological exams and Pap tests are essential for early detection and prevention of cervical diseases.

Gonorrhea is a sexually transmitted infection (STI) caused by the bacterium Neisseria gonorrhoeae, also known as "gono" bacteria. It can infect various parts of the body including the genitals, rectum, and throat. The bacteria are typically transmitted through sexual contact with an infected person.

Symptoms may vary but often include abnormal discharge from the genitals or rectum, painful or burning sensations during urination, and in women, vaginal bleeding between periods. However, many people with gonorrhea do not develop symptoms, making it essential to get tested regularly if you are sexually active with multiple partners or have unprotected sex.

If left untreated, gonorrhea can lead to severe complications such as pelvic inflammatory disease (PID) in women and epididymitis in men, which may result in infertility. In rare cases, it can spread to the bloodstream and cause life-threatening conditions like sepsis.

Gonorrhea is curable with appropriate antibiotic treatment; however, drug-resistant strains of the bacteria have emerged, making accurate diagnosis and effective treatment increasingly challenging. Prevention methods include using condoms during sexual activity and practicing safe sex habits.

The cervix uteri, often simply referred to as the cervix, is the lower part of the uterus (womb) that connects to the vagina. It has an opening called the external os through which menstrual blood exits the uterus and sperm enters during sexual intercourse. During childbirth, the cervix dilates or opens to allow for the passage of the baby through the birth canal.

Trachoma is a chronic infectious disease caused by the bacterium Chlamydia trachomatis. It primarily affects the eyes, causing repeated infections that lead to scarring of the inner eyelid and eyelashes turning inward (trichiasis), which can result in damage to the cornea and blindness if left untreated.

The disease is spread through direct contact with eye or nose discharge from infected individuals, often through contaminated fingers, shared towels, or flies that have come into contact with the discharge. Trachoma is prevalent in areas with poor sanitation and limited access to clean water, making it a significant public health issue in many developing countries.

Preventive measures include improving personal hygiene, such as washing hands regularly, promoting facial cleanliness, and providing safe water and sanitation facilities. Treatment typically involves antibiotics to eliminate the infection and surgery for advanced cases with trichiasis or corneal damage.

'Chlamydophila psittaci' is a gram-negative, obligate intracellular bacterium that causes psittacosis, also known as parrot fever. It is commonly found in birds, particularly parrots and psittacines, but can also infect other bird species, mammals, and humans. In humans, it can cause a wide range of symptoms, including fever, headache, cough, and pneumonia. Human-to-human transmission is rare, and the disease is typically acquired through inhalation of dried secretions or feces from infected birds.

Pelvic Inflammatory Disease (PID) is a medical condition characterized by inflammation of the reproductive organs in women, specifically the uterus, fallopian tubes, and/or ovaries. It is often caused by an infection that ascends from the cervix or vagina into the upper genital tract. The infectious agents are usually sexually transmitted bacteria such as Neisseria gonorrhoeae and Chlamydia trachomatis, but other organisms can also be responsible.

Symptoms of PID may include lower abdominal pain, irregular menstrual bleeding, vaginal discharge with an unpleasant odor, fever, painful sexual intercourse, or pain in the lower back. However, some women with PID may not experience any symptoms at all. If left untreated, PID can lead to serious complications such as infertility, ectopic pregnancy, and chronic pelvic pain.

Diagnosis of PID is typically based on a combination of clinical findings, physical examination, and laboratory tests. Treatment usually involves antibiotics to eradicate the infection and may also include pain management and other supportive measures. In some cases, hospitalization may be necessary for more intensive treatment or if complications arise.

The urethra is the tube that carries urine from the bladder out of the body. In males, it also serves as the conduit for semen during ejaculation. The male urethra is longer than the female urethra and is divided into sections: the prostatic, membranous, and spongy (or penile) urethra. The female urethra extends from the bladder to the external urethral orifice, which is located just above the vaginal opening.

'Chlamydia muridarum' is a species of the genus Chlamydia, which are obligate intracellular bacteria that can cause infectious diseases in humans and animals. 'Chlamydia muridarum' is closely related to 'Chlamydia trachomatis', which is a major cause of sexually transmitted infections in humans.

'Chlamydia muridarum' is primarily found in rodents, particularly mice, and can cause respiratory tract infections and reproductive tract diseases in these animals. It has been used as a model organism to study the pathogenesis and immunology of Chlamydia infections in mammals.

The medical relevance of 'Chlamydia muridarum' lies in its use as a research tool to better understand Chlamydia infections and develop new treatments and vaccines for these diseases. However, it is not considered a direct threat to human health, as it does not naturally infect humans.

Salpingitis is a medical term that refers to the inflammation of the fallopian tubes, which are the pair of narrow tubes that transport the egg from the ovaries to the uterus during ovulation. This condition can occur due to various reasons, including bacterial infections (such as chlamydia or gonorrhea), pelvic inflammatory disease, or complications following surgical procedures.

Acute salpingitis is characterized by symptoms like lower abdominal pain, fever, vaginal discharge, and irregular menstrual bleeding. Chronic salpingitis may not present any noticeable symptoms, but it can lead to complications such as infertility, ectopic pregnancy, or fallopian tube damage if left untreated. Treatment typically involves antibiotics to eliminate the infection and, in severe cases, surgery to remove or repair damaged tissues.

Urethritis is a medical condition that refers to the inflammation of the urethra, which is the tube that carries urine from the bladder out of the body. Urethritis can be caused by various factors, including bacterial or viral infections, chemical irritants, or trauma to the urethra.

The most common cause of urethritis is a bacterial infection, such as chlamydia or gonorrhea, which can be transmitted through sexual contact. Other symptoms of urethritis may include pain or burning during urination, discharge from the urethra, and frequent urination.

Urethritis is typically diagnosed through a physical examination and laboratory tests to identify the underlying cause of the inflammation. Treatment for urethritis depends on the cause but may include antibiotics or other medications to treat infections, as well as measures to relieve symptoms such as pain and discomfort.

Sexually Transmitted Diseases (STDs) are infections that can be passed from one person to another through sexual contact. When referring to bacterial STDs, these are infections caused by bacteria. Examples of bacterial STDs include chlamydia, gonorrhea, syphilis, and pelvic inflammatory disease (PID). These infections can be treated with antibiotics, but if left untreated, they can cause serious health problems, such as infertility, organ damage, and even death. It is important to practice safe sex and get regular STD screenings to prevent and promptly treat bacterial STDs.

Neisseria gonorrhoeae is a species of gram-negative, aerobic diplococcus that is the etiologic agent of gonorrhea, a sexually transmitted infection. It is commonly found in the mucous membranes of the reproductive tract, including the cervix, urethra, and rectum, as well as the throat and eyes. The bacterium can cause a range of symptoms, including discharge, burning during urination, and, in women, abnormal menstrual bleeding. If left untreated, it can lead to more serious complications, such as pelvic inflammatory disease and infertility. It is important to note that N. gonorrhoeae has developed resistance to many antibiotics over time, making treatment more challenging. A culture or nucleic acid amplification test (NAAT) is used for the diagnosis of this infection.

Bacterial antibodies are a type of antibodies produced by the immune system in response to an infection caused by bacteria. These antibodies are proteins that recognize and bind to specific antigens on the surface of the bacterial cells, marking them for destruction by other immune cells. Bacterial antibodies can be classified into several types based on their structure and function, including IgG, IgM, IgA, and IgE. They play a crucial role in the body's defense against bacterial infections and provide immunity to future infections with the same bacteria.

Uterine cervical diseases refer to conditions that affect the cervix, which is the lower part of the uterus that opens into the vagina. These diseases can range from minor abnormalities to more serious conditions, such as:

1. Cervical dysplasia: This is a precancerous condition characterized by the presence of abnormal cells on the cervix. It is usually caused by the human papillomavirus (HPV) and can be detected through a Pap test.
2. Cervical cancer: This is a malignant tumor that develops in the cervical tissue. The most common type of cervical cancer is squamous cell carcinoma, which arises from the cells lining the surface of the cervix.
3. Cervicitis: This is an inflammation of the cervix, which can be caused by infections, irritants, or allergies. Symptoms may include vaginal discharge, pain, and bleeding.
4. Cervical polyps: These are benign growths that develop on the cervix. They are usually small and asymptomatic but can cause abnormal vaginal bleeding or discharge.
5. Cervical incompetence: This is a condition where the cervix begins to open prematurely during pregnancy, leading to a risk of miscarriage or preterm labor.

It's important to note that regular screening and early detection can help prevent or manage many cervical diseases, including cervical cancer.

Bacterial outer membrane proteins (OMPs) are a type of protein found in the outer membrane of gram-negative bacteria. The outer membrane is a unique characteristic of gram-negative bacteria, and it serves as a barrier that helps protect the bacterium from hostile environments. OMPs play a crucial role in maintaining the structural integrity and selective permeability of the outer membrane. They are involved in various functions such as nutrient uptake, transport, adhesion, and virulence factor secretion.

OMPs are typically composed of beta-barrel structures that span the bacterial outer membrane. These proteins can be classified into several groups based on their size, function, and structure. Some of the well-known OMP families include porins, autotransporters, and two-partner secretion systems.

Porins are the most abundant type of OMPs and form water-filled channels that allow the passive diffusion of small molecules, ions, and nutrients across the outer membrane. Autotransporters are a diverse group of OMPs that play a role in bacterial pathogenesis by secreting virulence factors or acting as adhesins. Two-partner secretion systems involve the cooperation between two proteins to transport effector molecules across the outer membrane.

Understanding the structure and function of bacterial OMPs is essential for developing new antibiotics and therapies that target gram-negative bacteria, which are often resistant to conventional treatments.

The Fluorescent Antibody Technique (FAT), Direct is a type of immunofluorescence assay used in laboratory diagnostic tests. It is a method for identifying and locating specific antigens in cells or tissues by using fluorescent-labeled antibodies that directly bind to the target antigen.

In this technique, a sample (such as a tissue section or cell smear) is prepared and then treated with a fluorescently labeled primary antibody that specifically binds to the antigen of interest. After washing away unbound antibodies, the sample is examined under a fluorescence microscope. If the antigen is present in the sample, it will be visible as distinct areas of fluorescence, allowing for the direct visualization and localization of the antigen within the cells or tissues.

Direct FAT is commonly used in diagnostic laboratories to identify and diagnose various infectious diseases, including bacterial, viral, and fungal infections. It can also be used to detect specific proteins or antigens in research and clinical settings.

Urine is a physiological excretory product that is primarily composed of water, urea, and various ions (such as sodium, potassium, chloride, and others) that are the byproducts of protein metabolism. It also contains small amounts of other substances like uric acid, creatinine, ammonia, and various organic compounds. Urine is produced by the kidneys through a process called urination or micturition, where it is filtered from the blood and then stored in the bladder until it is excreted from the body through the urethra. The color, volume, and composition of urine can provide important diagnostic information about various medical conditions.

Inclusion conjunctivitis is a type of bacterial conjunctivitis (inflammation of the conjunctiva) that is caused by specific types of bacteria, most commonly Chlamydia trachomatis. It is also known as trachoma, which is a leading infectious cause of blindness worldwide. The infection leads to the formation of small, inclusion-containing intracytoplasmic inclusions in the conjunctival epithelial cells, hence the name "inclusion conjunctivitis."

The symptoms of inclusion conjunctivitis include redness, irritation, and discharge from the eyes. It can also cause swelling of the lymph nodes near the ears. In severe cases, it can lead to scarring and damage to the cornea, potentially resulting in vision loss. The infection is typically spread through direct contact with eye or nose discharge from an infected person, and it can also be sexually transmitted.

Treatment for inclusion conjunctivitis usually involves antibiotics, such as azithromycin or doxycycline, to eliminate the bacteria causing the infection. It is important to complete the full course of treatment to ensure that the infection is fully cleared and to prevent recurrence. In addition, good hygiene practices, such as frequent handwashing and avoiding sharing personal items like towels and washcloths, can help prevent the spread of the infection.

Inclusion bodies are abnormal, intracellular accumulations or aggregations of various misfolded proteins, protein complexes, or other materials within the cells of an organism. They can be found in various tissues and cell types and are often associated with several pathological conditions, including infectious diseases, neurodegenerative disorders, and genetic diseases.

Inclusion bodies can vary in size, shape, and location depending on the specific disease or condition. Some inclusion bodies have a characteristic appearance under the microscope, such as eosinophilic (pink) staining with hematoxylin and eosin (H&E) histological stain, while others may require specialized stains or immunohistochemical techniques to identify the specific misfolded proteins involved.

Examples of diseases associated with inclusion bodies include:

1. Infectious diseases: Some viral infections, such as HIV, hepatitis B and C, and herpes simplex virus, can lead to the formation of inclusion bodies within infected cells.
2. Neurodegenerative disorders: Several neurodegenerative diseases are characterized by the presence of inclusion bodies, including Alzheimer's disease (amyloid-beta plaques and tau tangles), Parkinson's disease (Lewy bodies), Huntington's disease (Huntingtin aggregates), and amyotrophic lateral sclerosis (TDP-43 and SOD1 inclusions).
3. Genetic diseases: Certain genetic disorders, such as Danon disease, neuronal intranuclear inclusion disease, and some lysosomal storage disorders, can also present with inclusion bodies due to the accumulation of abnormal proteins or metabolic products within cells.

The exact role of inclusion bodies in disease pathogenesis remains unclear; however, they are often associated with cellular dysfunction, oxidative stress, and increased inflammation, which can contribute to disease progression and neurodegeneration.

Nucleic acid amplification techniques (NAATs) are medical laboratory methods used to increase the number of copies of a specific DNA or RNA sequence. These techniques are widely used in molecular biology and diagnostics, including the detection and diagnosis of infectious diseases, genetic disorders, and cancer.

The most commonly used NAAT is the polymerase chain reaction (PCR), which involves repeated cycles of heating and cooling to separate and replicate DNA strands. Other NAATs include loop-mediated isothermal amplification (LAMP), nucleic acid sequence-based amplification (NASBA), and transcription-mediated amplification (TMA).

NAATs offer several advantages over traditional culture methods for detecting pathogens, including faster turnaround times, increased sensitivity and specificity, and the ability to detect viable but non-culturable organisms. However, they also require specialized equipment and trained personnel, and there is a risk of contamination and false positive results if proper precautions are not taken.

Urethral diseases refer to a range of conditions that affect the urethra, which is the tube that carries urine from the bladder out of the body. These diseases can cause various symptoms such as pain or discomfort during urination, difficulty in urinating, blood in urine, and abnormal discharge. Some common urethral diseases include urethritis (inflammation of the urethra), urethral stricture (narrowing of the urethra due to scar tissue or inflammation), and urethral cancer. The causes of urethral diseases can vary, including infections, injuries, congenital abnormalities, and certain medical conditions. Proper diagnosis and treatment are essential for managing urethral diseases and preventing complications.

Porins are a type of protein found in the outer membrane of gram-negative bacteria. They form water-filled channels, or pores, that allow small molecules such as ions, nutrients, and waste products to pass through the otherwise impermeable outer membrane. Porins are important for the survival of gram-negative bacteria, as they enable the selective transport of essential molecules while providing a barrier against harmful substances.

There are different types of porins, classified based on their structure and function. Some examples include:

1. General porins (also known as nonspecific porins): These are the most common type of porins and form large, water-filled channels that allow passive diffusion of small molecules up to 600-700 Da in size. They typically have a trimeric structure, with three identical or similar subunits forming a pore in the membrane.
2. Specific porins: These porins are more selective in the molecules they allow to pass through and often have smaller pores than general porins. They can be involved in the active transport of specific molecules or ions, requiring energy from the cell.
3. Autotransporters: While not strictly considered porins, autotransporter proteins share some structural similarities with porins and are involved in the transport of protein domains across the outer membrane. They consist of an N-terminal passenger domain and a C-terminal translocator domain, which forms a β-barrel pore in the outer membrane through which the passenger domain is transported.

Porins have attracted interest as potential targets for antibiotic development, as they play crucial roles in bacterial survival and virulence. Inhibiting porin function or blocking the pores could disrupt essential processes in gram-negative bacteria, providing a new approach to treating infections caused by these organisms.

Ligase Chain Reaction (LCR) is a highly specific and sensitive method used in molecular biology for the detection of point mutations or small deletions or insertions in DNA. It is an enzymatic reaction-based technique that relies on the repeated ligation of adjacent oligonucleotide probes to form a continuous strand, followed by thermal denaturation and reannealing of the strands.

The LCR process involves the use of a thermostable ligase enzyme, which catalyzes the formation of a phosphodiester bond between two adjacent oligonucleotide probes that are hybridized to complementary sequences in the target DNA. The oligonucleotides are designed to have a gap at the site of the mutation or deletion/insertion, such that ligation can only occur if the probe sequences match perfectly with the target DNA.

After each round of ligation and denaturation, the reaction mixture is subjected to PCR amplification using primers flanking the region of interest. The amplified products are then analyzed for the presence or absence of ligated probes, indicating the presence or absence of the mutation or deletion/insertion in the target DNA.

LCR has been widely used in diagnostic and research applications, including the detection of genetic diseases, infectious agents, and cancer-associated mutations. However, it has largely been replaced by other more sensitive and high-throughput methods such as real-time PCR and next-generation sequencing.

Specimen handling is a set of procedures and practices followed in the collection, storage, transportation, and processing of medical samples or specimens (e.g., blood, tissue, urine, etc.) for laboratory analysis. Proper specimen handling ensures accurate test results, patient safety, and data integrity. It includes:

1. Correct labeling of the specimen container with required patient information.
2. Using appropriate containers and materials to collect, store, and transport the specimen.
3. Following proper collection techniques to avoid contamination or damage to the specimen.
4. Adhering to specific storage conditions (temperature, time, etc.) before testing.
5. Ensuring secure and timely transportation of the specimen to the laboratory.
6. Properly documenting all steps in the handling process for traceability and quality assurance.

Polymerase Chain Reaction (PCR) is a laboratory technique used to amplify specific regions of DNA. It enables the production of thousands to millions of copies of a particular DNA sequence in a rapid and efficient manner, making it an essential tool in various fields such as molecular biology, medical diagnostics, forensic science, and research.

The PCR process involves repeated cycles of heating and cooling to separate the DNA strands, allow primers (short sequences of single-stranded DNA) to attach to the target regions, and extend these primers using an enzyme called Taq polymerase, resulting in the exponential amplification of the desired DNA segment.

In a medical context, PCR is often used for detecting and quantifying specific pathogens (viruses, bacteria, fungi, or parasites) in clinical samples, identifying genetic mutations or polymorphisms associated with diseases, monitoring disease progression, and evaluating treatment effectiveness.

Azithromycin is a widely used antibiotic drug that belongs to the class of macrolides. It works by inhibiting bacterial protein synthesis, which leads to the death of susceptible bacteria. This medication is active against a broad range of gram-positive and gram-negative bacteria, atypical bacteria, and some parasites.

Azithromycin is commonly prescribed to treat various bacterial infections, such as:

1. Respiratory tract infections, including pneumonia, bronchitis, and sinusitis
2. Skin and soft tissue infections
3. Sexually transmitted diseases, like chlamydia
4. Otitis media (middle ear infection)
5. Traveler's diarrhea

The drug is available in various forms, including tablets, capsules, suspension, and intravenous solutions. The typical dosage for adults ranges from 250 mg to 500 mg per day, depending on the type and severity of the infection being treated.

Like other antibiotics, azithromycin should be used judiciously to prevent antibiotic resistance. It is essential to complete the full course of treatment as prescribed by a healthcare professional, even if symptoms improve before finishing the medication.

Bacteriological techniques refer to the various methods and procedures used in the laboratory for the cultivation, identification, and study of bacteria. These techniques are essential in fields such as medicine, biotechnology, and research. Here are some common bacteriological techniques:

1. **Sterilization**: This is a process that eliminates or kills all forms of life, including bacteria, viruses, fungi, and spores. Common sterilization methods include autoclaving (using steam under pressure), dry heat (in an oven), chemical sterilants, and radiation.

2. **Aseptic Technique**: This refers to practices used to prevent contamination of sterile materials or environments with microorganisms. It includes the use of sterile equipment, gloves, and lab coats, as well as techniques such as flaming, alcohol swabbing, and using aseptic transfer devices.

3. **Media Preparation**: This involves the preparation of nutrient-rich substances that support bacterial growth. There are various types of media, including solid (agar), liquid (broth), and semi-solid (e.g., stab agar). The choice of medium depends on the type of bacteria being cultured and the purpose of the investigation.

4. **Inoculation**: This is the process of introducing a bacterial culture into a medium. It can be done using a loop, swab, or needle. The inoculum should be taken from a pure culture to avoid contamination.

5. **Incubation**: After inoculation, the bacteria are allowed to grow under controlled conditions of temperature, humidity, and atmospheric composition. This process is called incubation.

6. **Staining and Microscopy**: Bacteria are too small to be seen with the naked eye. Therefore, they need to be stained and observed under a microscope. Gram staining is a common method used to differentiate between two major groups of bacteria based on their cell wall composition.

7. **Biochemical Tests**: These are tests used to identify specific bacterial species based on their biochemical characteristics, such as their ability to ferment certain sugars, produce particular enzymes, or resist certain antibiotics.

8. **Molecular Techniques**: Advanced techniques like PCR and DNA sequencing can provide more precise identification of bacteria. They can also be used for genetic analysis and epidemiological studies.

Remember, handling microorganisms requires careful attention to biosafety procedures to prevent accidental infection or environmental contamination.

Bacterial DNA refers to the genetic material found in bacteria. It is composed of a double-stranded helix containing four nucleotide bases - adenine (A), thymine (T), guanine (G), and cytosine (C) - that are linked together by phosphodiester bonds. The sequence of these bases in the DNA molecule carries the genetic information necessary for the growth, development, and reproduction of bacteria.

Bacterial DNA is circular in most bacterial species, although some have linear chromosomes. In addition to the main chromosome, many bacteria also contain small circular pieces of DNA called plasmids that can carry additional genes and provide resistance to antibiotics or other environmental stressors.

Unlike eukaryotic cells, which have their DNA enclosed within a nucleus, bacterial DNA is present in the cytoplasm of the cell, where it is in direct contact with the cell's metabolic machinery. This allows for rapid gene expression and regulation in response to changing environmental conditions.

Vaginal diseases refer to various medical conditions that affect the vagina, which is the female reproductive organ that extends from the cervix (the lower part of the uterus) to the external part of the genitalia (vulva). These diseases can cause a range of symptoms, including discharge, itching, burning, pain, and discomfort. Some common vaginal diseases include:

1. Vaginitis: It is an inflammation or infection of the vagina that can cause abnormal discharge, itching, and irritation. The most common causes of vaginitis are bacterial vaginosis, yeast infections, and trichomoniasis.
2. Vulvovaginitis: It is an inflammation or infection of both the vagina and vulva that can cause redness, swelling, itching, and pain. The causes of vulvovaginitis are similar to those of vaginitis and include bacterial infections, yeast infections, and sexually transmitted infections (STIs).
3. Vaginal dryness: It is a common condition that affects many women, especially after menopause. It can cause discomfort during sexual intercourse and lead to other symptoms such as itching and burning.
4. Vaginal cysts: These are fluid-filled sacs that develop in the vagina due to various reasons, including inflammation, injury, or congenital abnormalities.
5. Vaginal cancer: It is a rare type of cancer that affects the vagina. The most common symptoms include abnormal vaginal bleeding, discharge, and pain during sexual intercourse.
6. Sexually transmitted infections (STIs): Several STIs, such as chlamydia, gonorrhea, genital herpes, and human papillomavirus (HPV), can affect the vagina and cause various symptoms, including discharge, pain, and sores.

It is essential to seek medical attention if you experience any symptoms of vaginal diseases to receive proper diagnosis and treatment.

Reactive arthritis is a form of inflammatory arthritis that occurs in response to an infection in another part of the body, such as the genitals, urinary tract, or gastrointestinal tract. It is also known as Reiter's syndrome. The symptoms of reactive arthritis include joint pain and swelling, typically affecting the knees, ankles, and feet; inflammation of the eyes, skin, and mucous membranes; and urethritis or cervicitis. It is more common in men than women and usually develops within 1-4 weeks after a bacterial infection. The diagnosis is made based on the symptoms, medical history, physical examination, and laboratory tests. Treatment typically includes antibiotics to eliminate the underlying infection and medications to manage the symptoms of arthritis.

Reagent kits, diagnostic are prepackaged sets of chemical reagents and other components designed for performing specific diagnostic tests or assays. These kits are often used in clinical laboratories to detect and measure the presence or absence of various biomarkers, such as proteins, antibodies, antigens, nucleic acids, or small molecules, in biological samples like blood, urine, or tissues.

Diagnostic reagent kits typically contain detailed instructions for their use, along with the necessary reagents, controls, and sometimes specialized equipment or supplies. They are designed to simplify the testing process, reduce human error, and increase standardization, ensuring accurate and reliable results. Examples of diagnostic reagent kits include those used for pregnancy tests, infectious disease screening, drug testing, genetic testing, and cancer biomarker detection.

Reproductive Tract Infections (RTIs) refer to infections that are localized in the reproductive organs, including the vagina, cervix, uterus, fallopian tubes, ovaries, and prostate gland. These infections can be caused by various microorganisms such as bacteria, viruses, fungi, or parasites.

RTIs can lead to a range of complications, including pelvic inflammatory disease (PID), ectopic pregnancy, infertility, and increased risk of HIV transmission. They can also cause symptoms such as abnormal vaginal discharge, pain during sexual intercourse, irregular menstrual bleeding, and lower abdominal pain.

RTIs are often sexually transmitted but can also be caused by other factors such as poor hygiene, use of intrauterine devices (IUDs), and invasive gynecological procedures. Prevention measures include safe sexual practices, good personal hygiene, and timely treatment of infections.

Mycoplasma genitalium is a small, bacteria that lack a cell wall and can be found in the urinary and genital tracts of humans. It's known to cause several urogenital infections, such as urethritis in men and cervicitis in women. In some cases, it may also lead to pelvic inflammatory disease (PID) and complications like infertility or ectopic pregnancy in women. Mycoplasma genitalium can be sexually transmitted and is often associated with HIV transmission. Due to its small size and atypical growth requirements, it can be challenging to culture and diagnose using standard microbiological methods. Molecular tests, such as nucleic acid amplification tests (NAATs), are commonly used for detection in clinical settings.

Genital diseases in males refer to various medical conditions that affect the male reproductive and urinary systems, including the penis, testicles, epididymis, vas deferens, seminal vesicles, prostate, and urethra. These conditions can be infectious, inflammatory, degenerative, or neoplastic (cancerous) in nature. Some common examples of male genital diseases include:

1. Balanitis: Inflammation of the foreskin and glans penis, often caused by infection, irritants, or poor hygiene.
2. Prostatitis: Inflammation of the prostate gland, which can be acute or chronic, bacterial or non-bacterial in origin.
3. Epididymitis: Inflammation of the epididymis, a coiled tube at the back of the testicle that stores and carries sperm. It is often caused by infection.
4. Orchitis: Inflammation of the testicle, usually resulting from infection or autoimmune disorders.
5. Testicular torsion: A surgical emergency characterized by twisting of the spermatic cord, leading to reduced blood flow and potential tissue damage in the testicle.
6. Varicocele: Dilated veins in the scrotum that can cause pain, discomfort, or fertility issues.
7. Peyronie's disease: A connective tissue disorder causing scarring and curvature of the penis during erections.
8. Penile cancer: Malignant growths on the penis, often squamous cell carcinomas, which can spread to other parts of the body if left untreated.
9. Benign prostatic hyperplasia (BPH): Non-cancerous enlargement of the prostate gland that can cause lower urinary tract symptoms such as difficulty initiating or maintaining a steady stream of urine.
10. Sexually transmitted infections (STIs): Infectious diseases, like chlamydia, gonorrhea, syphilis, and human papillomavirus (HPV), that can be transmitted through sexual contact and affect the male genital region.

Sexually Transmitted Diseases (STDs), also known as Sexually Transmitted Infections (STIs), are a group of diseases or infections that spread primarily through sexual contact, including vaginal, oral, and anal sex. They can also be transmitted through non-sexual means such as mother-to-child transmission during childbirth or breastfeeding, or via shared needles.

STDs can cause a range of symptoms, from mild to severe, and some may not show any symptoms at all. Common STDs include chlamydia, gonorrhea, syphilis, HIV/AIDS, human papillomavirus (HPV), herpes simplex virus (HSV), hepatitis B, and pubic lice.

If left untreated, some STDs can lead to serious health complications, such as infertility, organ damage, blindness, or even death. It is important to practice safe sex and get regular screenings for STDs if you are sexually active, especially if you have multiple partners or engage in high-risk behaviors.

Preventive measures include using barrier methods of protection, such as condoms, dental dams, and female condoms, getting vaccinated against HPV and hepatitis B, and limiting the number of sexual partners. If you suspect that you may have an STD, it is important to seek medical attention promptly for diagnosis and treatment.

Sensitivity and specificity are statistical measures used to describe the performance of a diagnostic test or screening tool in identifying true positive and true negative results.

* Sensitivity refers to the proportion of people who have a particular condition (true positives) who are correctly identified by the test. It is also known as the "true positive rate" or "recall." A highly sensitive test will identify most or all of the people with the condition, but may also produce more false positives.
* Specificity refers to the proportion of people who do not have a particular condition (true negatives) who are correctly identified by the test. It is also known as the "true negative rate." A highly specific test will identify most or all of the people without the condition, but may also produce more false negatives.

In medical testing, both sensitivity and specificity are important considerations when evaluating a diagnostic test. High sensitivity is desirable for screening tests that aim to identify as many cases of a condition as possible, while high specificity is desirable for confirmatory tests that aim to rule out the condition in people who do not have it.

It's worth noting that sensitivity and specificity are often influenced by factors such as the prevalence of the condition in the population being tested, the threshold used to define a positive result, and the reliability and validity of the test itself. Therefore, it's important to consider these factors when interpreting the results of a diagnostic test.

The urogenital system is a part of the human body that includes the urinary and genital systems. The urinary system consists of the kidneys, ureters, bladder, and urethra, which work together to produce, store, and eliminate urine. On the other hand, the genital system, also known as the reproductive system, is responsible for the production, development, and reproduction of offspring. In males, this includes the testes, epididymis, vas deferens, seminal vesicles, prostate gland, bulbourethral glands, and penis. In females, it includes the ovaries, fallopian tubes, uterus, vagina, mammary glands, and external genitalia.

The urogenital system is closely related anatomically and functionally. For example, in males, the urethra serves as a shared conduit for both urine and semen, while in females, the urethra and vagina are separate but adjacent structures. Additionally, some organs, such as the prostate gland in males and the Skene's glands in females, have functions that overlap between the urinary and genital systems.

Disorders of the urogenital system can affect both the urinary and reproductive functions, leading to a range of symptoms such as pain, discomfort, infection, and difficulty with urination or sexual activity. Proper care and maintenance of the urogenital system are essential for overall health and well-being.

Bacterial antigens are substances found on the surface or produced by bacteria that can stimulate an immune response in a host organism. These antigens can be proteins, polysaccharides, teichoic acids, lipopolysaccharides, or other molecules that are recognized as foreign by the host's immune system.

When a bacterial antigen is encountered by the host's immune system, it triggers a series of responses aimed at eliminating the bacteria and preventing infection. The host's immune system recognizes the antigen as foreign through the use of specialized receptors called pattern recognition receptors (PRRs), which are found on various immune cells such as macrophages, dendritic cells, and neutrophils.

Once a bacterial antigen is recognized by the host's immune system, it can stimulate both the innate and adaptive immune responses. The innate immune response involves the activation of inflammatory pathways, the recruitment of immune cells to the site of infection, and the production of antimicrobial peptides.

The adaptive immune response, on the other hand, involves the activation of T cells and B cells, which are specific to the bacterial antigen. These cells can recognize and remember the antigen, allowing for a more rapid and effective response upon subsequent exposures.

Bacterial antigens are important in the development of vaccines, as they can be used to stimulate an immune response without causing disease. By identifying specific bacterial antigens that are associated with virulence or pathogenicity, researchers can develop vaccines that target these antigens and provide protection against infection.

Psittacosis is a zoonotic infectious disease caused by the bacterium Chlamydia psittaci, which is typically found in birds. It can be transmitted to humans through inhalation of dried secretions or feces from infected birds, and less commonly, through direct contact with infected birds or their environments. The disease is characterized by symptoms such as fever, headache, muscle aches, cough, and pneumonia. In severe cases, it can lead to respiratory failure, heart inflammation, and even death if left untreated. It's important to note that psittacosis is treatable with antibiotics, and early diagnosis and treatment are crucial for a favorable prognosis.

Female genitalia refer to the reproductive and sexual organs located in the female pelvic region. They are primarily involved in reproduction, menstruation, and sexual activity. The external female genitalia, also known as the vulva, include the mons pubis, labia majora, labia minora, clitoris, and the external openings of the urethra and vagina. The internal female genitalia consist of the vagina, cervix, uterus, fallopian tubes, and ovaries. These structures work together to facilitate menstruation, fertilization, pregnancy, and childbirth.

Doxycycline is a broad-spectrum antibiotic, which is a type of medication used to treat infections caused by bacteria and other microorganisms. It belongs to the tetracycline class of antibiotics. Doxycycline works by inhibiting the production of proteins that bacteria need to survive and multiply.

Doxycycline is used to treat a wide range of bacterial infections, including respiratory infections, skin infections, urinary tract infections, sexually transmitted diseases, and severe acne. It is also used to prevent malaria in travelers who are visiting areas where malaria is common.

Like all antibiotics, doxycycline should be taken exactly as directed by a healthcare professional. Misuse of antibiotics can lead to the development of drug-resistant bacteria, which can make infections harder to treat in the future.

It's important to note that doxycycline can cause photosensitivity, so it is recommended to avoid prolonged sun exposure and use sun protection while taking this medication. Additionally, doxycycline should not be taken during pregnancy or by children under the age of 8 due to potential dental and bone development issues.

HeLa cells are a type of immortalized cell line used in scientific research. They are derived from a cancer that developed in the cervical tissue of Henrietta Lacks, an African-American woman, in 1951. After her death, cells taken from her tumor were found to be capable of continuous division and growth in a laboratory setting, making them an invaluable resource for medical research.

HeLa cells have been used in a wide range of scientific studies, including research on cancer, viruses, genetics, and drug development. They were the first human cell line to be successfully cloned and are able to grow rapidly in culture, doubling their population every 20-24 hours. This has made them an essential tool for many areas of biomedical research.

It is important to note that while HeLa cells have been instrumental in numerous scientific breakthroughs, the story of their origin raises ethical questions about informed consent and the use of human tissue in research.

The vagina is the canal that joins the cervix (the lower part of the uterus) to the outside of the body. It also is known as the birth canal because babies pass through it during childbirth. The vagina is where sexual intercourse occurs and where menstrual blood exits the body. It has a flexible wall that can expand and retract. During sexual arousal, the vaginal walls swell with blood to become more elastic in order to accommodate penetration.

It's important to note that sometimes people use the term "vagina" to refer to the entire female genital area, including the external structures like the labia and clitoris. But technically, these are considered part of the vulva, not the vagina.

Chlamydophila infections are caused by bacteria belonging to the genus Chlamydophila, which includes several species that can infect humans and animals. The two most common species that cause infections in humans are Chlamydophila pneumoniae and Chlamydophila trachomatis.

Chlamydophila pneumoniae is responsible for respiratory infections, including pneumonia, bronchitis, and sinusitis. It is usually spread through respiratory droplets and can cause both mild and severe illnesses.

Chlamydophila trachomatis causes a wide range of infections, depending on the serovar (strain) involved. The most common types of Chlamydia trachomatis infections include:

1. Nongonococcal urethritis and cervicitis: These are sexually transmitted infections that can cause inflammation of the urethra and cervix, respectively. Symptoms may include discharge, pain during urination, and painful intercourse.
2. Lymphogranuloma venereum (LGV): This is a sexually transmitted infection that primarily affects the lymphatic system. It can cause symptoms such as genital ulcers, swollen lymph nodes, and rectal pain and discharge.
3. Trachoma: This is an eye infection caused by a specific serovar of Chlamydia trachomatis. It is the leading infectious cause of blindness worldwide and primarily affects populations in developing countries with poor sanitation.
4. Inclusion conjunctivitis: This is an eye infection that mainly affects newborns, causing inflammation of the conjunctiva (the membrane lining the eyelids). It can be transmitted from mother to child during childbirth and may lead to vision problems if left untreated.

Diagnosis of Chlamydophila infections typically involves laboratory tests such as nucleic acid amplification tests (NAATs) or culture methods. Treatment usually consists of antibiotics, such as azithromycin or doxycycline, and may involve additional measures depending on the site and severity of infection. Prevention strategies include practicing safe sex, maintaining good hygiene, and receiving appropriate vaccinations for at-risk populations.

Fallopian tube diseases refer to conditions that affect the function or structure of the Fallopian tubes, which are a pair of narrow tubes that transport the egg from the ovaries to the uterus during ovulation and provide a pathway for sperm to reach the egg for fertilization. Some common Fallopian tube diseases include:

1. Salpingitis: This is an inflammation of the Fallopian tubes, usually caused by an infection. The infection can be bacterial, viral, or fungal in origin and can lead to scarring, blockage, or damage to the Fallopian tubes.
2. Hydrosalpinx: This is a condition where one or both of the Fallopian tubes become filled with fluid, leading to swelling and distension of the tube. The cause of hydrosalpinx can be infection, endometriosis, or previous surgery.
3. Endometriosis: This is a condition where the tissue that lines the inside of the uterus grows outside of it, including on the Fallopian tubes. This can lead to scarring, adhesions, and blockage of the tubes.
4. Ectopic pregnancy: This is a pregnancy that develops outside of the uterus, usually in the Fallopian tube. An ectopic pregnancy can cause the Fallopian tube to rupture, leading to severe bleeding and potentially life-threatening complications.
5. Tubal ligation: This is a surgical procedure that involves blocking or cutting the Fallopian tubes to prevent pregnancy. In some cases, tubal ligation can lead to complications such as ectopic pregnancy or tubal sterilization syndrome, which is a condition where the fallopian tubes reconnect and allow for pregnancy to occur.

These conditions can cause infertility, chronic pain, and other health problems, and may require medical or surgical treatment.

Female infertility is a condition characterized by the inability to conceive after 12 months or more of regular, unprotected sexual intercourse or the inability to carry a pregnancy to a live birth. The causes of female infertility can be multifactorial and may include issues with ovulation, damage to the fallopian tubes or uterus, endometriosis, hormonal imbalances, age-related factors, and other medical conditions.

Some common causes of female infertility include:

1. Ovulation disorders: Conditions such as polycystic ovary syndrome (PCOS), thyroid disorders, premature ovarian failure, and hyperprolactinemia can affect ovulation and lead to infertility.
2. Damage to the fallopian tubes: Pelvic inflammatory disease, endometriosis, or previous surgeries can cause scarring and blockages in the fallopian tubes, preventing the egg and sperm from meeting.
3. Uterine abnormalities: Structural issues with the uterus, such as fibroids, polyps, or congenital defects, can interfere with implantation and pregnancy.
4. Age-related factors: As women age, their fertility declines due to a decrease in the number and quality of eggs.
5. Other medical conditions: Certain medical conditions, such as diabetes, celiac disease, and autoimmune disorders, can contribute to infertility.

In some cases, female infertility can be treated with medications, surgery, or assisted reproductive technologies (ART) like in vitro fertilization (IVF). A thorough evaluation by a healthcare professional is necessary to determine the underlying cause and develop an appropriate treatment plan.

Prevalence, in medical terms, refers to the total number of people in a given population who have a particular disease or condition at a specific point in time, or over a specified period. It is typically expressed as a percentage or a ratio of the number of cases to the size of the population. Prevalence differs from incidence, which measures the number of new cases that develop during a certain period.

The Fallopian tubes, also known as uterine tubes or oviducts, are a pair of slender tubular structures in the female reproductive system. They play a crucial role in human reproduction by providing a passageway for the egg (ovum) from the ovary to the uterus (womb).

Each Fallopian tube is typically around 7.6 to 10 centimeters long and consists of four parts: the interstitial part, the isthmus, the ampulla, and the infundibulum. The fimbriated end of the infundibulum, which resembles a fringe or frill, surrounds and captures the released egg from the ovary during ovulation.

Fertilization usually occurs in the ampulla when sperm meets the egg after sexual intercourse. Once fertilized, the zygote (fertilized egg) travels through the Fallopian tube toward the uterus for implantation and further development. The cilia lining the inner surface of the Fallopian tubes help propel the egg and the zygote along their journey.

In some cases, abnormalities or blockages in the Fallopian tubes can lead to infertility or ectopic pregnancies, which are pregnancies that develop outside the uterus, typically within the Fallopian tube itself.

Proctitis is a medical condition that refers to inflammation of the lining of the rectum, which is the lower end of the colon. The symptoms of proctitis may include rectal pain, discomfort, or a feeling of fullness; rectal bleeding, often in the form of mucus or blood; diarrhea; and urgency to have a bowel movement.

Proctitis can be caused by a variety of factors, including infections (such as sexually transmitted infections, foodborne illnesses, or inflammatory bowel diseases like Crohn's disease or ulcerative colitis), radiation therapy, trauma, or autoimmune disorders. The diagnosis of proctitis typically involves a physical examination, medical history, and sometimes endoscopic procedures to visualize the rectum and take tissue samples for further testing. Treatment depends on the underlying cause but may include antibiotics, anti-inflammatory medications, or other therapies.

Mycoplasma infections refer to illnesses caused by bacteria belonging to the genus Mycoplasma. These are among the smallest free-living organisms, lacking a cell wall and possessing a unique molecular structure. They can cause various respiratory tract infections (like pneumonia, bronchitis), urogenital infections, and other systemic diseases in humans, animals, and birds.

The most common Mycoplasma species that infect humans include M. pneumoniae, M. genitalium, M. hominis, and Ureaplasma urealyticum. Transmission usually occurs through respiratory droplets or sexual contact. Symptoms can vary widely depending on the site of infection but may include cough, chest pain, difficulty breathing, fatigue, joint pain, rash, and genital discharge or pelvic pain in women. Diagnosis often requires specific laboratory tests due to their unique growth requirements and resistance to many common antibiotics. Treatment typically involves macrolide or fluoroquinolone antibiotics.

Ureaplasma is a genus of bacteria that are commonly found in the lower reproductive tract of humans. They belong to the family Mycoplasmataceae and are characterized by their small size and lack of a cell wall. Ureaplasmas are unique because they have the ability to metabolize urea, which they use as a source of energy for growth.

There are several species of Ureaplasma that can infect humans, including Ureaplasma urealyticum and Ureaplasma parvum. These bacteria can cause a variety of clinical syndromes, particularly in individuals with compromised immune systems or underlying respiratory or genitourinary tract disorders.

Infections caused by Ureaplasma are often asymptomatic but can lead to complications such as urethritis, cervicitis, pelvic inflammatory disease, and pneumonia. In newborns, Ureaplasma infections have been associated with bronchopulmonary dysplasia, a chronic lung disorder that can lead to long-term respiratory problems.

Diagnosis of Ureaplasma infections typically involves the use of nucleic acid amplification tests (NAATs) such as polymerase chain reaction (PCR) assays. Treatment usually consists of antibiotics such as macrolides or fluoroquinolones, which are effective against these bacteria.

Trichomonas vaginalis is a species of protozoan parasite that causes the sexually transmitted infection known as trichomoniasis. It primarily infects the urogenital tract, with women being more frequently affected than men. The parasite exists as a motile, pear-shaped trophozoite, measuring about 10-20 micrometers in size.

T. vaginalis infection can lead to various symptoms, including vaginal discharge with an unpleasant odor, itching, and irritation in women, while men may experience urethral discharge or discomfort during urination. However, up to 50% of infected individuals might not develop any noticeable symptoms, making the infection challenging to recognize and treat without medical testing.

Diagnosis typically involves microscopic examination of vaginal secretions or urine samples, although nucleic acid amplification tests (NAATs) are becoming more common due to their higher sensitivity and specificity. Treatment usually consists of oral metronidazole or tinidazole, which are antibiotics that target the parasite's ability to reproduce. It is essential to treat both partners simultaneously to prevent reinfection and ensure successful eradication of the parasite.

Medical mass screening, also known as population screening, is a public health service that aims to identify and detect asymptomatic individuals in a given population who have or are at risk of a specific disease. The goal is to provide early treatment, reduce morbidity and mortality, and prevent the spread of diseases within the community.

A mass screening program typically involves offering a simple, quick, and non-invasive test to a large number of people in a defined population, regardless of their risk factors or symptoms. Those who test positive are then referred for further diagnostic tests and appropriate medical interventions. Examples of mass screening programs include mammography for breast cancer detection, PSA (prostate-specific antigen) testing for prostate cancer, and fecal occult blood testing for colorectal cancer.

It is important to note that mass screening programs should be evidence-based, cost-effective, and ethically sound, with clear benefits outweighing potential harms. They should also consider factors such as the prevalence of the disease in the population, the accuracy and reliability of the screening test, and the availability and effectiveness of treatment options.

Conjunctivitis is an inflammation or infection of the conjunctiva, a thin, clear membrane that covers the inner surface of the eyelids and the outer surface of the eye. The condition can cause redness, itching, burning, tearing, discomfort, and a gritty feeling in the eyes. It can also result in a discharge that can be clear, yellow, or greenish.

Conjunctivitis can have various causes, including bacterial or viral infections, allergies, irritants (such as smoke, chlorine, or contact lens solutions), and underlying medical conditions (like dry eye or autoimmune disorders). Treatment depends on the cause of the condition but may include antibiotics, antihistamines, anti-inflammatory medications, or warm compresses.

It is essential to maintain good hygiene practices, like washing hands frequently and avoiding touching or rubbing the eyes, to prevent spreading conjunctivitis to others. If you suspect you have conjunctivitis, it's recommended that you consult an eye care professional for a proper diagnosis and treatment plan.

Chaperonin 60, also known as CPN60 or HSP60 (heat shock protein 60), is a type of molecular chaperone found in the mitochondria of eukaryotic cells. Molecular chaperones are proteins that assist in the proper folding and assembly of other proteins. Chaperonin 60 is a member of the HSP (heat shock protein) family, which are proteins that are upregulated in response to stressful conditions such as heat shock or oxidative stress.

Chaperonin 60 forms a large complex with a barrel-shaped structure that provides a protected environment for unfolded or misfolded proteins to fold properly. The protein substrate is bound inside the central cavity of the chaperonin complex, and then undergoes a series of conformational changes that facilitate its folding. Chaperonin 60 has been shown to play important roles in mitochondrial protein import, folding, and assembly, as well as in the regulation of apoptosis (programmed cell death).

Defects in chaperonin 60 have been linked to a variety of human diseases, including neurodegenerative disorders, cardiovascular disease, and cancer.

"Evaluation studies" is a broad term that refers to the systematic assessment or examination of a program, project, policy, intervention, or product. The goal of an evaluation study is to determine its merits, worth, and value by measuring its effects, efficiency, and impact. There are different types of evaluation studies, including formative evaluations (conducted during the development or implementation of a program to provide feedback for improvement), summative evaluations (conducted at the end of a program to determine its overall effectiveness), process evaluations (focusing on how a program is implemented and delivered), outcome evaluations (assessing the short-term and intermediate effects of a program), and impact evaluations (measuring the long-term and broad consequences of a program).

In medical contexts, evaluation studies are often used to assess the safety, efficacy, and cost-effectiveness of new treatments, interventions, or technologies. These studies can help healthcare providers make informed decisions about patient care, guide policymakers in developing evidence-based policies, and promote accountability and transparency in healthcare systems. Examples of evaluation studies in medicine include randomized controlled trials (RCTs) that compare the outcomes of a new treatment to those of a standard or placebo treatment, observational studies that examine the real-world effectiveness and safety of interventions, and economic evaluations that assess the costs and benefits of different healthcare options.

Chlamydiaceae infections are caused by bacteria belonging to the family Chlamydiaceae, including the species Chlamydia trachomatis and Chlamydia pneumoniae. These bacteria can infect various tissues in the human body and cause a range of diseases.

Chlamydia trachomatis is the most common bacterial sexually transmitted infection (STI) worldwide, causing urethritis, cervicitis, pelvic inflammatory disease, epididymitis, and infertility in both men and women. It can also cause ocular and respiratory tract infections, including trachoma, the leading infectious cause of blindness worldwide.

Chlamydia pneumoniae is a common cause of community-acquired pneumonia and bronchitis, as well as pharyngitis, sinusitis, and otitis media. It can also cause chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD).

Chlamydia psittaci is a zoonotic pathogen that primarily infects birds but can occasionally cause severe respiratory illness in humans, known as psittacosis or ornithosis.

Diagnosis of Chlamydiaceae infections typically involves nucleic acid amplification tests (NAATs) such as polymerase chain reaction (PCR) assays, which can detect the genetic material of the bacteria in clinical samples. Treatment usually involves antibiotics such as azithromycin or doxycycline, which can eliminate the infection and prevent complications. Prevention measures include safe sexual practices, proper hygiene, and avoiding contact with infected animals.

Bacterial proteins are a type of protein that are produced by bacteria as part of their structural or functional components. These proteins can be involved in various cellular processes, such as metabolism, DNA replication, transcription, and translation. They can also play a role in bacterial pathogenesis, helping the bacteria to evade the host's immune system, acquire nutrients, and multiply within the host.

Bacterial proteins can be classified into different categories based on their function, such as:

1. Enzymes: Proteins that catalyze chemical reactions in the bacterial cell.
2. Structural proteins: Proteins that provide structural support and maintain the shape of the bacterial cell.
3. Signaling proteins: Proteins that help bacteria to communicate with each other and coordinate their behavior.
4. Transport proteins: Proteins that facilitate the movement of molecules across the bacterial cell membrane.
5. Toxins: Proteins that are produced by pathogenic bacteria to damage host cells and promote infection.
6. Surface proteins: Proteins that are located on the surface of the bacterial cell and interact with the environment or host cells.

Understanding the structure and function of bacterial proteins is important for developing new antibiotics, vaccines, and other therapeutic strategies to combat bacterial infections.

'Chlamydophila pneumoniae' is a type of bacteria that can cause respiratory infections in humans. It is the causative agent of a form of pneumonia known as "atypical pneumonia," which is characterized by milder symptoms and a slower onset than other types of pneumonia.

The bacteria are transmitted through respiratory droplets, such as those produced when an infected person coughs or sneezes. 'Chlamydophila pneumoniae' infections can occur throughout the year, but they are more common in the fall and winter months.

Symptoms of a 'Chlamydophila pneumoniae' infection may include cough, chest pain, fever, fatigue, and difficulty breathing. The infection can also cause other respiratory symptoms, such as sore throat, headache, and muscle aches. In some cases, the infection may spread to other parts of the body, causing complications such as ear infections or inflammation of the heart or brain.

Diagnosis of 'Chlamydophila pneumoniae' infection typically involves testing a sample of respiratory secretions, such as sputum or nasal swabs, for the presence of the bacteria. Treatment usually involves antibiotics, such as azithromycin or doxycycline, which are effective against 'Chlamydophila pneumoniae'.

It's important to note that while 'Chlamydophila pneumoniae' infections can cause serious respiratory illness, they are generally not as severe as other types of bacterial pneumonia. However, if left untreated, the infection can lead to complications and worsening symptoms.

The conjunctiva is the mucous membrane that lines the inner surface of the eyelids and covers the front part of the eye, also known as the sclera. It helps to keep the eye moist and protected from irritants. The conjunctiva can become inflamed or infected, leading to conditions such as conjunctivitis (pink eye).

A vaginal smear, also known as a Pap test or Pap smear, is a medical procedure in which a sample of cells is collected from the cervix (the lower part of the uterus that opens into the vagina) and examined under a microscope. The purpose of this test is to detect abnormal cells, including precancerous changes, that may indicate the presence of cervical cancer or other conditions such as infections or inflammation.

During the procedure, a speculum is inserted into the vagina to allow the healthcare provider to visualize the cervix. A spatula or brush is then used to gently scrape cells from the surface of the cervix. The sample is spread onto a microscope slide and sent to a laboratory for analysis.

Regular Pap smears are recommended for women as part of their routine healthcare, as they can help detect abnormalities at an early stage when they are more easily treated. The frequency of Pap smears may vary depending on age, medical history, and other factors. It is important to follow the recommendations of a healthcare provider regarding the timing and frequency of Pap smears.

Infectious pregnancy complications refer to infections that occur during pregnancy and can affect the mother, fetus, or both. These infections can lead to serious consequences such as preterm labor, low birth weight, birth defects, stillbirth, or even death. Some common infectious agents that can cause pregnancy complications include:

1. Bacteria: Examples include group B streptococcus, Escherichia coli, and Listeria monocytogenes, which can cause sepsis, meningitis, or pneumonia in the mother and lead to preterm labor or stillbirth.
2. Viruses: Examples include cytomegalovirus, rubella, varicella-zoster, and HIV, which can cause congenital anomalies, developmental delays, or transmission of the virus to the fetus.
3. Parasites: Examples include Toxoplasma gondii, which can cause severe neurological damage in the fetus if transmitted during pregnancy.
4. Fungi: Examples include Candida albicans, which can cause fungal infections in the mother and lead to preterm labor or stillbirth.

Preventive measures such as vaccination, good hygiene practices, and avoiding high-risk behaviors can help reduce the risk of infectious pregnancy complications. Prompt diagnosis and treatment of infections during pregnancy are also crucial to prevent adverse outcomes.

Chlamydiaceae is a family of bacteria that includes several species known to cause diseases in humans and animals. The most well-known member of this family is Chlamydia trachomatis, which is responsible for a range of human illnesses including sexually transmitted infections (STIs) such as chlamydia, urethritis, cervicitis, and pelvic inflammatory disease. It can also cause ocular infections like trachoma, which is the leading infectious cause of blindness worldwide.

Another important member of this family is Chlamydophila pneumoniae, which causes respiratory infections such as community-acquired pneumonia and bronchitis. Additionally, Chlamydophila psittaci can cause psittacosis, a zoonotic disease that humans can acquire from infected birds.

Chlamydiaceae bacteria are obligate intracellular pathogens, meaning they require host cells to survive and replicate. They have a unique biphasic developmental cycle, involving two distinct forms: the elementary body (EB) and the reticulate body (RB). The EB is the infectious form that attaches to and enters host cells, while the RB is the metabolically active form that multiplies within the host cell. Once the RBs have replicated sufficiently, they convert back into EBs, which are then released from the host cell to infect other cells.

Effective antibiotic treatment for Chlamydiaceae infections typically involves macrolides (such as azithromycin) or tetracyclines (such as doxycycline). Prevention strategies include safe sexual practices, proper hygiene, and avoiding contact with infected animals or their secretions.

Trichomonas infection, also known as trichomoniasis, is a sexually transmitted infection caused by the protozoan parasite Trichomonas vaginalis. It primarily affects the urogenital tract and is more common in women than men. The symptoms in women can include vaginal discharge with an unpleasant smell, itching, redness, and pain during sexual intercourse or urination. Many men with trichomoniasis do not develop any symptoms, although some may experience discomfort, burning after urination, or a slight discharge from the penis. If left untreated, trichomoniasis can increase the risk of acquiring or transmitting other sexually transmitted infections, such as HIV. Diagnosis is usually made through microscopic examination of a sample of vaginal or urethral discharge, and treatment typically involves prescription antibiotics like metronidazole or tinidazole.

Molecular sequence data refers to the specific arrangement of molecules, most commonly nucleotides in DNA or RNA, or amino acids in proteins, that make up a biological macromolecule. This data is generated through laboratory techniques such as sequencing, and provides information about the exact order of the constituent molecules. This data is crucial in various fields of biology, including genetics, evolution, and molecular biology, allowing for comparisons between different organisms, identification of genetic variations, and studies of gene function and regulation.

Immunoenzyme techniques are a group of laboratory methods used in immunology and clinical chemistry that combine the specificity of antibody-antigen reactions with the sensitivity and amplification capabilities of enzyme reactions. These techniques are primarily used for the detection, quantitation, or identification of various analytes (such as proteins, hormones, drugs, viruses, or bacteria) in biological samples.

In immunoenzyme techniques, an enzyme is linked to an antibody or antigen, creating a conjugate. This conjugate then interacts with the target analyte in the sample, forming an immune complex. The presence and amount of this immune complex can be visualized or measured by detecting the enzymatic activity associated with it.

There are several types of immunoenzyme techniques, including:

1. Enzyme-linked Immunosorbent Assay (ELISA): A widely used method for detecting and quantifying various analytes in a sample. In ELISA, an enzyme is attached to either the capture antibody or the detection antibody. After the immune complex formation, a substrate is added that reacts with the enzyme, producing a colored product that can be measured spectrophotometrically.
2. Immunoblotting (Western blot): A method used for detecting specific proteins in a complex mixture, such as a protein extract from cells or tissues. In this technique, proteins are separated by gel electrophoresis and transferred to a membrane, where they are probed with an enzyme-conjugated antibody directed against the target protein.
3. Immunohistochemistry (IHC): A method used for detecting specific antigens in tissue sections or cells. In IHC, an enzyme-conjugated primary or secondary antibody is applied to the sample, and the presence of the antigen is visualized using a chromogenic substrate that produces a colored product at the site of the antigen-antibody interaction.
4. Immunofluorescence (IF): A method used for detecting specific antigens in cells or tissues by employing fluorophore-conjugated antibodies. The presence of the antigen is visualized using a fluorescence microscope.
5. Enzyme-linked immunosorbent assay (ELISA): A method used for detecting and quantifying specific antigens or antibodies in liquid samples, such as serum or culture supernatants. In ELISA, an enzyme-conjugated detection antibody is added after the immune complex formation, and a substrate is added that reacts with the enzyme to produce a colored product that can be measured spectrophotometrically.

These techniques are widely used in research and diagnostic laboratories for various applications, including protein characterization, disease diagnosis, and monitoring treatment responses.

Trichomonas vaginitis is a type of vaginal infection caused by the protozoan parasite Trichomonas vaginalis. It is transmitted through sexual contact and primarily affects the urogenital tract. The infection can cause various symptoms in women, such as vaginal discharge with an unpleasant smell, itching, redness, and pain during urination or sex. However, up to 50% of infected individuals may be asymptomatic. In men, it often does not cause any symptoms but can lead to urethritis (inflammation of the urethra). Diagnosis is usually made through microscopic examination of vaginal secretions or a nucleic acid amplification test (NAAT). Treatment typically involves prescription antibiotics like metronidazole or tinidazole, targeting both sexual partners to prevent reinfection.

Bacterial conjunctivitis is a type of conjunctivitis (inflammation of the conjunctiva) that is caused by bacterial infection. The most common bacteria responsible for this condition are Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae.

The symptoms of bacterial conjunctivitis include redness, swelling, and pain in the eye, along with a thick, sticky discharge that can cause the eyelids to stick together, especially upon waking up. Other symptoms may include tearing, itching, and sensitivity to light. Bacterial conjunctivitis is highly contagious and can spread easily through contact with infected individuals or contaminated objects such as towels, handkerchiefs, or makeup.

Treatment for bacterial conjunctivitis typically involves the use of antibiotic eye drops or ointments to eliminate the infection. In some cases, oral antibiotics may also be prescribed. It is important to seek medical attention if you suspect that you have bacterial conjunctivitis, as untreated infections can lead to serious complications such as corneal ulcers and vision loss.

Anti-bacterial agents, also known as antibiotics, are a type of medication used to treat infections caused by bacteria. These agents work by either killing the bacteria or inhibiting their growth and reproduction. There are several different classes of anti-bacterial agents, including penicillins, cephalosporins, fluoroquinolones, macrolides, and tetracyclines, among others. Each class of antibiotic has a specific mechanism of action and is used to treat certain types of bacterial infections. It's important to note that anti-bacterial agents are not effective against viral infections, such as the common cold or flu. Misuse and overuse of antibiotics can lead to antibiotic resistance, which is a significant global health concern.

Sexual behavior refers to any physical or emotional interaction that has the potential to lead to sexual arousal and/or satisfaction. This can include a wide range of activities, such as kissing, touching, fondling, oral sex, vaginal sex, anal sex, and masturbation. It can also involve the use of sexual aids, such as vibrators or pornography.

Sexual behavior is influenced by a variety of factors, including biological, psychological, social, and cultural influences. It is an important aspect of human development and relationships, and it is essential to healthy sexual functioning and satisfaction. However, sexual behavior can also be associated with risks, such as sexually transmitted infections (STIs) and unintended pregnancies, and it is important for individuals to engage in safe and responsible sexual practices.

It's important to note that sexual behavior can vary widely among individuals and cultures, and what may be considered normal or acceptable in one culture or context may not be in another. It's also important to recognize that all individuals have the right to make informed decisions about their own sexual behavior and to have their sexual rights and autonomy respected.

Immunoglobulin G (IgG) is a type of antibody, which is a protective protein produced by the immune system in response to foreign substances like bacteria or viruses. IgG is the most abundant type of antibody in human blood, making up about 75-80% of all antibodies. It is found in all body fluids and plays a crucial role in fighting infections caused by bacteria, viruses, and toxins.

IgG has several important functions:

1. Neutralization: IgG can bind to the surface of bacteria or viruses, preventing them from attaching to and infecting human cells.
2. Opsonization: IgG coats the surface of pathogens, making them more recognizable and easier for immune cells like neutrophils and macrophages to phagocytose (engulf and destroy) them.
3. Complement activation: IgG can activate the complement system, a group of proteins that work together to help eliminate pathogens from the body. Activation of the complement system leads to the formation of the membrane attack complex, which creates holes in the cell membranes of bacteria, leading to their lysis (destruction).
4. Antibody-dependent cellular cytotoxicity (ADCC): IgG can bind to immune cells like natural killer (NK) cells and trigger them to release substances that cause target cells (such as virus-infected or cancerous cells) to undergo apoptosis (programmed cell death).
5. Immune complex formation: IgG can form immune complexes with antigens, which can then be removed from the body through various mechanisms, such as phagocytosis by immune cells or excretion in urine.

IgG is a critical component of adaptive immunity and provides long-lasting protection against reinfection with many pathogens. It has four subclasses (IgG1, IgG2, IgG3, and IgG4) that differ in their structure, function, and distribution in the body.

DEAE-Dextran is a water-soluble polymer that is often used in biochemistry and molecular biology research. The acronym "DEAE" stands for diethylaminoethyl, which is a type of charged group that can bind to and interact with negatively charged molecules such as DNA. Dextran is a type of sugar polymer that makes the DEAE groups more soluble in water.

In research settings, DEAE-Dextran is commonly used to precipitate DNA or to create complexes with DNA that can be used for various purposes, such as transfection (the process of introducing genetic material into cells). The positive charge of the DEAE groups allows them to interact strongly with the negative charges on the DNA molecule, forming a stable complex that can be taken up by cells.

It's important to note that DEAE-Dextran is not used in clinical medicine, but rather as a research tool in laboratory settings.

Mycoplasma hominis is a species of bacteria that lack a cell wall and are among the smallest free-living organisms. They are commonly found as part of the normal flora in the genitourinary tract of humans, particularly in the urethra, cervix, and vagina. However, they can also cause various infections, especially in individuals with compromised immune systems or in the presence of other risk factors.

M. hominis has been associated with several types of infections, including:

1. Genital tract infections: M. hominis can cause pelvic inflammatory disease (PID), cervicitis, urethritis, and endometritis in women. In men, it may lead to urethritis and prostatitis.
2. Postpartum and post-abortion fever: M. hominis can contribute to febrile morbidity following delivery or abortion.
3. Respiratory tract infections: While rare, M. hominis has been implicated in some cases of respiratory tract infections, particularly in immunocompromised individuals.
4. Joint and soft tissue infections: M. hominis can cause septic arthritis, osteomyelitis, and other soft tissue infections, especially in patients with underlying joint diseases or compromised immune systems.
5. Central nervous system (CNS) infections: Although uncommon, M. hominis has been associated with CNS infections such as meningitis and brain abscesses, primarily in immunocompromised individuals.
6. Bloodstream infections: Bacteremia due to M. hominis is rare but can occur in immunocompromised patients or those with indwelling catheters.

Diagnosis of M. hominis infections typically involves the detection of the organism through various laboratory methods, such as culture, polymerase chain reaction (PCR), or serological tests. Treatment usually consists of antibiotics that target mycoplasmas, such as macrolides (e.g., azithromycin) or tetracyclines (e.g., doxycycline). However, resistance to certain antibiotics has been reported in some M. hominis strains.

The Fluorescent Antibody Technique (FAT) is a type of immunofluorescence assay used in laboratory medicine and pathology for the detection and localization of specific antigens or antibodies in tissues, cells, or microorganisms. In this technique, a fluorescein-labeled antibody is used to selectively bind to the target antigen or antibody, forming an immune complex. When excited by light of a specific wavelength, the fluorescein label emits light at a longer wavelength, typically visualized as green fluorescence under a fluorescence microscope.

The FAT is widely used in diagnostic microbiology for the identification and characterization of various bacteria, viruses, fungi, and parasites. It has also been applied in the diagnosis of autoimmune diseases and certain cancers by detecting specific antibodies or antigens in patient samples. The main advantage of FAT is its high sensitivity and specificity, allowing for accurate detection and differentiation of various pathogens and disease markers. However, it requires specialized equipment and trained personnel to perform and interpret the results.

Mycoplasmatales infections refer to illnesses caused by bacteria belonging to the order Mycoplasmatales, which are characterized as the smallest self-replicating organisms lacking a cell wall. The most common pathogens in this group include Mycoplasma pneumoniae, M. genitalium, M. hominis, and Ureaplasma urealyticum.

Mycoplasma pneumoniae is a leading cause of community-acquired pneumonia, while M. genitalium is associated with sexually transmitted infections, including urethritis, cervicitis, and pelvic inflammatory disease. M. hominis and U. urealyticum are typically commensals but can cause invasive diseases such as septic arthritis, endocarditis, or meningitis, especially in immunocompromised individuals.

Infections caused by these organisms often present with nonspecific symptoms, making diagnosis challenging. Diagnosis usually involves serological tests, nucleic acid amplification techniques (NAATs), or culture methods. Treatment typically includes macrolides, tetracyclines, or fluoroquinolones, depending on the specific pathogen and its antibiotic susceptibility profile.

Contact tracing is a key public health strategy used to control the spread of infectious diseases. It involves identifying and monitoring individuals (contacts) who have come into close contact with an infected person (case), to prevent further transmission of the disease. The process typically includes:

1. Case identification: Identifying and confirming cases of infection through diagnostic testing.
2. Contact identification: Finding people who may have been in close contact with the infected case during their infectious period, which is the time when they can transmit the infection to others. Close contacts are usually defined as individuals who have had face-to-face contact with a confirmed case within a certain distance (often 6 feet or closer) and/or shared confined spaces for prolonged periods (usually more than 15 minutes).
3. Contact listing: Recording the identified contacts' information, including their names, addresses, phone numbers, and potentially other demographic data.
4. Risk assessment: Evaluating the level of risk associated with each contact based on factors such as the type of exposure, duration of contact, and the infectiousness of the case.
5. Notification: Informing contacts about their potential exposure to the infection and providing them with necessary health information, education, and guidance. This may include recommendations for self-quarantine, symptom monitoring, testing, and vaccination if available.
6. Follow-up: Monitoring and supporting contacts during their quarantine or isolation period, which typically lasts 14 days from the last exposure to the case. Public health professionals will check in with contacts regularly to assess their symptoms, provide additional guidance, and ensure they are adhering to the recommended infection prevention measures.
7. Data management: Documenting and reporting contact tracing activities for public health surveillance, evaluation, and future planning purposes.

Contact tracing is a critical component of infectious disease control and has been used effectively in managing various outbreaks, including tuberculosis, HIV/AIDS, Ebola, and more recently, COVID-19.

Bacterial vaccines are types of vaccines that are created using bacteria or parts of bacteria as the immunogen, which is the substance that triggers an immune response in the body. The purpose of a bacterial vaccine is to stimulate the immune system to develop protection against specific bacterial infections.

There are several types of bacterial vaccines, including:

1. Inactivated or killed whole-cell vaccines: These vaccines contain entire bacteria that have been killed or inactivated through various methods, such as heat or chemicals. The bacteria can no longer cause disease, but they still retain the ability to stimulate an immune response.
2. Subunit, protein, or polysaccharide vaccines: These vaccines use specific components of the bacterium, such as proteins or polysaccharides, that are known to trigger an immune response. By using only these components, the vaccine can avoid using the entire bacterium, which may reduce the risk of adverse reactions.
3. Live attenuated vaccines: These vaccines contain live bacteria that have been weakened or attenuated so that they cannot cause disease but still retain the ability to stimulate an immune response. This type of vaccine can provide long-lasting immunity, but it may not be suitable for people with weakened immune systems.

Bacterial vaccines are essential tools in preventing and controlling bacterial infections, reducing the burden of diseases such as tuberculosis, pneumococcal disease, meningococcal disease, and Haemophilus influenzae type b (Hib) disease. They work by exposing the immune system to a harmless form of the bacteria or its components, which triggers the production of antibodies and memory cells that can recognize and fight off future infections with that same bacterium.

It's important to note that while vaccines are generally safe and effective, they may cause mild side effects such as pain, redness, or swelling at the injection site, fever, or fatigue. Serious side effects are rare but can occur, so it's essential to consult with a healthcare provider before receiving any vaccine.

Genitalia, also known as the genitals, refer to the reproductive organs located in the pelvic region. In males, these include the penis and testicles, while in females, they consist of the vulva, vagina, clitoris, and ovaries. Genitalia are essential for sexual reproduction and can also be associated with various medical conditions, such as infections, injuries, or congenital abnormalities.

Leukorrhea is a medical term that refers to a white or yellowish-white discharge from the vagina. It's composed of cells shed from the lining of the vagina, fluid, and bacteria. While it can be normal and occur throughout a woman's reproductive years due to hormonal changes, it can also indicate an infection or inflammation, particularly when it's accompanied by symptoms like itching, burning, foul odor, or pain. Common causes of abnormal leukorrhea include bacterial vaginosis, yeast infections, and sexually transmitted infections.

Serotyping is a laboratory technique used to classify microorganisms, such as bacteria and viruses, based on the specific antigens or proteins present on their surface. It involves treating the microorganism with different types of antibodies and observing which ones bind to its surface. Each distinct set of antigens corresponds to a specific serotype, allowing for precise identification and characterization of the microorganism. This technique is particularly useful in epidemiology, vaccine development, and infection control.

Prostitution is not typically defined in medical terms, but it is a social and legal issue. However, in the context of public health, prostitution might be defined as the act or practice of engaging in sexual activity for payment, which can carry significant risks to physical and mental health, including exposure to sexually transmitted infections (STIs), violence, and psychological trauma.

Prostitution is often associated with marginalization, poverty, and social inequality, and it can be a complex issue that involves questions of personal autonomy, consent, and human rights. It's important to note that the legal and cultural approaches to prostitution vary widely around the world, ranging from criminalization to decriminalization and legalization.

Rectal diseases refer to conditions that affect the structure or function of the rectum, which is the lower end of the large intestine, just above the anus. The rectum serves as a storage area for stool before it is eliminated from the body. Some common rectal diseases include:

1. Hemorrhoids: Swollen veins in the rectum or anus that can cause pain, itching, bleeding, and discomfort.
2. Rectal cancer: Abnormal growth of cells in the rectum that can invade and destroy nearby tissue and spread to other parts of the body.
3. Anal fissures: Small tears in the lining of the anus that can cause pain, bleeding, and itching.
4. Rectal prolapse: A condition where the rectum slips outside the anus, causing discomfort, fecal incontinence, and other symptoms.
5. Inflammatory bowel disease (IBD): A group of chronic inflammatory conditions that affect the digestive tract, including the rectum, such as Crohn's disease and ulcerative colitis.
6. Rectal abscess: A collection of pus in the rectum caused by an infection, which can cause pain, swelling, and fever.
7. Fistula-in-ano: An abnormal connection between the rectum and the skin around the anus, which can cause drainage of pus or stool.
8. Rectal foreign bodies: Objects that are accidentally or intentionally inserted into the rectum and can cause injury, infection, or obstruction.

These are just a few examples of rectal diseases, and there are many other conditions that can affect the rectum. If you experience any symptoms related to the rectum, it is important to seek medical attention from a healthcare professional for proper diagnosis and treatment.

Pharyngeal diseases refer to conditions that affect the pharynx, which is the part of the throat that lies behind the nasal cavity and mouth, and above the esophagus and larynx. The pharynx plays a crucial role in swallowing, speaking, and breathing. Pharyngeal diseases can cause symptoms such as sore throat, difficulty swallowing, pain during swallowing, swollen lymph nodes, and earaches.

Some common pharyngeal diseases include:

1. Pharyngitis: Inflammation of the pharynx, often caused by a viral or bacterial infection.
2. Tonsillitis: Inflammation of the tonsils, which are two masses of lymphoid tissue located on either side of the back of the throat.
3. Epiglottitis: Inflammation of the epiglottis, a flap of cartilage that covers the windpipe during swallowing to prevent food and liquids from entering the lungs.
4. Abscesses: A collection of pus in the pharynx caused by a bacterial infection.
5. Cancer: Malignant tumors that can develop in the pharynx, often caused by smoking or heavy alcohol use.
6. Dysphagia: Difficulty swallowing due to nerve damage, muscle weakness, or structural abnormalities in the pharynx.
7. Stridor: Noisy breathing caused by a narrowed or obstructed airway in the pharynx.

Treatment for pharyngeal diseases depends on the underlying cause and may include antibiotics, pain relievers, surgery, or radiation therapy.

Immunoglobulin A (IgA) is a type of antibody that plays a crucial role in the immune function of the human body. It is primarily found in external secretions, such as saliva, tears, breast milk, and sweat, as well as in mucous membranes lining the respiratory and gastrointestinal tracts. IgA exists in two forms: a monomeric form found in serum and a polymeric form found in secretions.

The primary function of IgA is to provide immune protection at mucosal surfaces, which are exposed to various environmental antigens, such as bacteria, viruses, parasites, and allergens. By doing so, it helps prevent the entry and colonization of pathogens into the body, reducing the risk of infections and inflammation.

IgA functions by binding to antigens present on the surface of pathogens or allergens, forming immune complexes that can neutralize their activity. These complexes are then transported across the epithelial cells lining mucosal surfaces and released into the lumen, where they prevent the adherence and invasion of pathogens.

In summary, Immunoglobulin A (IgA) is a vital antibody that provides immune defense at mucosal surfaces by neutralizing and preventing the entry of harmful antigens into the body.

Ophthalmia Neonatorum is a medical term that refers to a conjunctivitis (inflammation of the conjunctiva) occurring in the first 28 days of life, often presenting with purulent discharge and redness of the eye. It can be caused by various microorganisms, including bacteria such as Neisseria gonorrhoeae, Chlamydia trachomatis, or bacterial flora from the mother's birth canal or hospital environment. Immediate treatment is necessary to prevent potential blindness and other complications. Prophylaxis with erythromycin ointment is often recommended for all newborns.

Ectopic pregnancy is a type of abnormal pregnancy that occurs outside the uterine cavity. The most common site for an ectopic pregnancy is the fallopian tube, accounting for about 95% of cases. This condition is also known as tubal pregnancy. Other less common sites include the ovary, cervix, and abdominal cavity.

In a normal pregnancy, the fertilized egg travels down the fallopian tube and implants itself in the lining of the uterus. However, in an ectopic pregnancy, the fertilized egg implants and starts to develop somewhere other than the uterus. The growing embryo cannot survive outside the uterus, and if left untreated, an ectopic pregnancy can cause life-threatening bleeding due to the rupture of the fallopian tube or other organs.

Symptoms of ectopic pregnancy may include abdominal pain, vaginal bleeding, shoulder pain, lightheadedness, fainting, and in severe cases, shock. Diagnosis is usually made through a combination of medical history, physical examination, ultrasound, and blood tests to measure the levels of human chorionic gonadotropin (hCG), a hormone produced during pregnancy.

Treatment for ectopic pregnancy depends on several factors, including the location, size, and growth rate of the ectopic mass, as well as the patient's overall health and desire for future pregnancies. Treatment options may include medication to stop the growth of the embryo or surgery to remove the ectopic tissue. In some cases, both methods may be used together. Early diagnosis and treatment can help prevent serious complications and improve the chances of preserving fertility in future pregnancies.

A base sequence in the context of molecular biology refers to the specific order of nucleotides in a DNA or RNA molecule. In DNA, these nucleotides are adenine (A), guanine (G), cytosine (C), and thymine (T). In RNA, uracil (U) takes the place of thymine. The base sequence contains genetic information that is transcribed into RNA and ultimately translated into proteins. It is the exact order of these bases that determines the genetic code and thus the function of the DNA or RNA molecule.

Vaginal discharge refers to the fluid that comes out of the vagina on a regular basis. It's a normal and healthy process for the body to keep the vagina clean and maintain its pH balance. The amount, color, and consistency of vaginal discharge can vary throughout a woman's menstrual cycle and can also be influenced by various factors such as pregnancy, sexual arousal, and infections.

Normal vaginal discharge is typically clear or white and may have a mild odor. However, if the discharge changes in color, consistency, or smell, or if it's accompanied by symptoms such as itching, burning, or pain, it could be a sign of an infection or other medical condition that requires treatment.

It is important to note that while vaginal discharge is a normal bodily function, any abnormal changes should be evaluated by a healthcare professional to ensure appropriate diagnosis and treatment.

Epididymitis is defined as the inflammation of the epididymis, a curved tube-like structure located at the back of the testicle that stores and transports sperm. The inflammation can result from infection, trauma, or other causes, and may cause symptoms such as pain, swelling, and tenderness in the scrotum. In some cases, epididymitis may also be associated with urinary tract infections, sexually transmitted infections, or other medical conditions. Treatment typically involves antibiotics to treat any underlying infection, as well as pain relief measures and supportive care to help reduce symptoms and promote healing.

I'm sorry for any confusion, but "Gambia" is not a medical term. It is the name of a country located in West Africa, officially known as the Republic of The Gambia. If you have any questions about medical terminology or health-related topics, I would be happy to try and help answer those for you.

Pregnancy is a physiological state or condition where a fertilized egg (zygote) successfully implants and grows in the uterus of a woman, leading to the development of an embryo and finally a fetus. This process typically spans approximately 40 weeks, divided into three trimesters, and culminates in childbirth. Throughout this period, numerous hormonal and physical changes occur to support the growing offspring, including uterine enlargement, breast development, and various maternal adaptations to ensure the fetus's optimal growth and well-being.

Bacteriuria is a medical term that refers to the presence of bacteria in the urine. The condition can be asymptomatic or symptomatic, and it can occur in various populations, including hospitalized patients, pregnant women, and individuals with underlying urologic abnormalities.

There are different types of bacteriuria, including:

1. Significant bacteriuria: This refers to the presence of a large number of bacteria in the urine (usually greater than 100,000 colony-forming units per milliliter or CFU/mL) and is often associated with urinary tract infection (UTI).
2. Contaminant bacteriuria: This occurs when bacteria from the skin or external environment enter the urine sample during collection, leading to a small number of bacteria present in the urine.
3. Asymptomatic bacteriuria: This refers to the presence of bacteria in the urine without any symptoms of UTI. It is more common in older adults, pregnant women, and individuals with diabetes or other underlying medical conditions.

The diagnosis of bacteriuria typically involves a urinalysis and urine culture to identify the type and quantity of bacteria present in the urine. Treatment depends on the type and severity of bacteriuria and may involve antibiotics to eliminate the infection. However, asymptomatic bacteriuria often does not require treatment unless it occurs in pregnant women or individuals undergoing urologic procedures.

Ureaplasma urealyticum is a type of bacteria that belongs to the genus Ureaplasma and the family Mycoplasmataceae. It is a non-motile, non-spore forming, microaerophilic organism, which means it requires reduced oxygen levels for growth.

Ureaplasma urealyticum is unique because it can hydrolyze urea to produce ammonia and carbon dioxide, which helps create a more favorable environment for its growth. This bacterium is commonly found in the genitourinary tract of humans and other primates. It can be part of the normal flora but may also cause infections under certain circumstances.

Infections caused by Ureaplasma urealyticum are often associated with the respiratory and urogenital tracts, particularly in premature infants, immunocompromised individuals, or those with underlying medical conditions. The bacterium can lead to various clinical manifestations, such as pneumonia, bronchopulmonary dysplasia, sepsis, meningitis, and urethritis. However, it is important to note that asymptomatic carriage of Ureaplasma urealyticum is also common, making the interpretation of its clinical significance challenging at times.

Diagnosis typically involves nucleic acid amplification tests (NAATs), such as polymerase chain reaction (PCR) assays, to detect the bacterium's genetic material in clinical samples. Treatment usually consists of antibiotics that target mycoplasmas, like macrolides or tetracyclines, but the choice and duration of therapy depend on the patient's age, immune status, and underlying medical conditions.

In medical terminology, "sexual partners" refers to individuals who engage in sexual activity with each other. This can include various forms of sexual contact, such as vaginal, anal, or oral sex. The term is often used in the context of discussing sexual health and the transmission of sexually transmitted infections (STIs). It's important to note that full disclosure of sexual partners to healthcare providers can help in diagnosing and treating STIs, as well as in understanding an individual's sexual health history.

Chlamydial pneumonia is a type of lung infection caused by the bacterium Chlamydophila pneumoniae (previously known as Chlamydia pneumoniae). It is often a mild to moderate respiratory infection, but in some cases, it can be more severe and require hospitalization.

The symptoms of chlamydial pneumonia may include cough, chest pain, fever, fatigue, and difficulty breathing. The infection is usually spread through respiratory droplets when an infected person coughs or sneezes. It can also be spread by touching contaminated surfaces and then touching the mouth or nose.

Chlamydial pneumonia is often treated with antibiotics, such as azithromycin or doxycycline. In some cases, hospitalization may be necessary for more severe infections, especially in people with weakened immune systems or other underlying health conditions.

It's worth noting that chlamydial pneumonia is different from chlamydia trachomatis, which is a sexually transmitted infection caused by a different species of Chlamydia.

A bacterial gene is a segment of DNA (or RNA in some viruses) that contains the genetic information necessary for the synthesis of a functional bacterial protein or RNA molecule. These genes are responsible for encoding various characteristics and functions of bacteria such as metabolism, reproduction, and resistance to antibiotics. They can be transmitted between bacteria through horizontal gene transfer mechanisms like conjugation, transformation, and transduction. Bacterial genes are often organized into operons, which are clusters of genes that are transcribed together as a single mRNA molecule.

It's important to note that the term "bacterial gene" is used to describe genetic elements found in bacteria, but not all genetic elements in bacteria are considered genes. For example, some DNA sequences may not encode functional products and are therefore not considered genes. Additionally, some bacterial genes may be plasmid-borne or phage-borne, rather than being located on the bacterial chromosome.

Bacterial vaginosis (BV) is a condition that occurs when there's an imbalance or overgrowth of bacteria in the vagina. It's not technically considered a sexually transmitted infection (STI), but certain activities such as unprotected sex can increase the risk of developing BV. The normal balance of bacteria in the vagina is disrupted, leading to symptoms such as abnormal vaginal discharge with a strong fishy odor, burning during urination, and itching or irritation around the outside of the vagina. Bacterial vaginosis is diagnosed through a pelvic examination and laboratory tests to identify the type of bacteria present in the vagina. Treatment typically involves antibiotics, either in the form of pills or creams that are inserted into the vagina. It's important to seek medical attention if you suspect you have bacterial vaginosis, as it can increase the risk of complications such as pelvic inflammatory disease and preterm labor during pregnancy.

A "false negative" reaction in medical testing refers to a situation where a diagnostic test incorrectly indicates the absence of a specific condition or disease, when in fact it is present. This can occur due to various reasons such as issues with the sensitivity of the test, improper sample collection, or specimen handling and storage.

False negative results can have serious consequences, as they may lead to delayed treatment, misdiagnosis, or a false sense of security for the patient. Therefore, it is essential to interpret medical test results in conjunction with other clinical findings, patient history, and physical examination. In some cases, repeating the test or using a different diagnostic method may be necessary to confirm the initial result.

Ureaplasma infections refer to conditions caused by the colonization or infection with the bacterial species Ureaplasma urealyticum and Ureaplasma parvum, which are commonly found in the genitourinary tract of humans. These bacteria are part of the normal flora but can cause infections under certain circumstances, such as in immunocompromised individuals or when they ascend to sterile sites like the upper respiratory tract or the amniotic fluid during pregnancy.

Ureaplasma infections can lead to a range of clinical manifestations, including urethritis, cystitis, pelvic inflammatory disease, and respiratory tract infections in newborns. However, it is important to note that the causative role of Ureaplasma spp. in many of these conditions is still a subject of debate, as they can also be found in asymptomatic individuals.

Diagnosis of Ureaplasma infections typically involves nucleic acid amplification tests (NAATs) or culture-based methods to detect the presence of the bacteria in clinical samples. Treatment usually consists of antibiotics that target the bacterial species, such as macrolides or fluoroquinolones, although the development of antimicrobial resistance is a growing concern.

Sulfisoxazole is an antibacterial drug, specifically a sulfonamide. It is defined as a synthetic, short-acting, bacteriostatic antibiotic that inhibits the growth of certain bacteria by interfering with their ability to synthesize folic acid, an essential component for their survival. Sulfisoxazole is used to treat various infections caused by susceptible bacteria, including respiratory tract infections, urinary tract infections, and skin infections.

It's important to note that the use of sulfonamides like sulfisoxazole has declined over time due to the emergence of bacterial resistance and the availability of alternative antibiotics with better safety profiles. Additionally, adverse reactions such as rashes, allergies, and blood disorders have been associated with their use, so they should be prescribed with caution and only when necessary.

"Chlamydophila" is a genus of bacteria that includes several species that can cause human diseases. The most well-known species in this genus is "Chlamydophila trachomatis," which is the leading cause of preventable blindness worldwide and can also cause sexually transmitted infections (STIs). Other species in the genus include "Chlamydophila pneumoniae," which can cause respiratory infections, and "Chlamydophila psittaci," which can cause psittacosis, a type of pneumonia that is often associated with exposure to birds.

It's worth noting that the taxonomy of these bacteria has been subject to some debate and revision in recent years. Some experts have proposed reclassifying the genus "Chlamydophila" as a subgroup within the genus "Chlamydia," which would make the species "Chlamydophila trachomatis" become "Chlamydia trachomatis," and so on. However, this proposal has not been universally accepted, and both classifications continue to be used in the scientific literature.

Venereology is a branch of medicine that deals with the study, diagnosis, treatment and prevention of sexually transmitted infections (STIs) or venereal diseases. The term "venereal" comes from Venus, the Roman goddess of love, due to the association of these diseases with sexual activity.

A medical professional who specializes in venereology is called a venereologist. They are trained to diagnose and manage various types of STIs, including chlamydia, gonorrhea, syphilis, herpes, HIV/AIDS, and genital warts, among others.

Venereologists work in various settings, such as hospitals, clinics, and public health departments. They often collaborate with other healthcare professionals, including primary care physicians, nurses, and counselors, to provide comprehensive care for patients with STIs. Additionally, venereologists play a crucial role in promoting sexual health education and advocating for policies that help prevent the spread of STIs.

"Abortion applicants" is not a standard medical term. However, in general, it may refer to individuals who are seeking to have an abortion procedure performed. This could include people of any gender, although the vast majority of those seeking abortions are women or pregnant individuals. The term "abortion applicant" may be used in legal or administrative contexts to describe someone who is applying for a legal abortion, particularly in places where there are restrictions or requirements that must be met before an abortion can be performed. It is important to note that access to safe and legal abortion is a fundamental human right recognized by many international organizations and medical associations.

Molecular diagnostic techniques are a group of laboratory methods used to analyze biological markers in DNA, RNA, and proteins to identify specific health conditions or diseases at the molecular level. These techniques include various methods such as polymerase chain reaction (PCR), DNA sequencing, gene expression analysis, fluorescence in situ hybridization (FISH), and mass spectrometry.

Molecular diagnostic techniques are used to detect genetic mutations, chromosomal abnormalities, viral and bacterial infections, and other molecular changes associated with various diseases, including cancer, genetic disorders, infectious diseases, and neurological disorders. These techniques provide valuable information for disease diagnosis, prognosis, treatment planning, and monitoring of treatment response.

Compared to traditional diagnostic methods, molecular diagnostic techniques offer several advantages, such as higher sensitivity, specificity, and speed. They can detect small amounts of genetic material or proteins, even in early stages of the disease, and provide accurate results with a lower risk of false positives or negatives. Additionally, molecular diagnostic techniques can be automated, standardized, and performed in high-throughput formats, making them suitable for large-scale screening and research applications.

An Enzyme-Linked Immunosorbent Assay (ELISA) is a type of analytical biochemistry assay used to detect and quantify the presence of a substance, typically a protein or peptide, in a liquid sample. It takes its name from the enzyme-linked antibodies used in the assay.

In an ELISA, the sample is added to a well containing a surface that has been treated to capture the target substance. If the target substance is present in the sample, it will bind to the surface. Next, an enzyme-linked antibody specific to the target substance is added. This antibody will bind to the captured target substance if it is present. After washing away any unbound material, a substrate for the enzyme is added. If the enzyme is present due to its linkage to the antibody, it will catalyze a reaction that produces a detectable signal, such as a color change or fluorescence. The intensity of this signal is proportional to the amount of target substance present in the sample, allowing for quantification.

ELISAs are widely used in research and clinical settings to detect and measure various substances, including hormones, viruses, and bacteria. They offer high sensitivity, specificity, and reproducibility, making them a reliable choice for many applications.

Ambulatory care facilities are healthcare providers where patients receive medical services, treatments, or procedures that do not require an overnight hospital stay. These facilities are often used for diagnosis, observation, and outpatient care such as same-day surgery, preventive health screenings, and minor procedures. They can include a wide range of settings like physician offices, community clinics, urgent care centers, dialysis centers, and surgical centers. The goal of ambulatory care facilities is to provide high-quality medical services in a convenient and cost-effective manner for patients who do not require hospitalization.

The cervix is the lower, narrow part of the uterus that opens into the vagina. Cervical mucus is a clear or cloudy secretion produced by glands in the cervix. The amount and consistency of cervical mucus changes throughout a woman's menstrual cycle, influenced by hormonal fluctuations.

During the fertile window (approximately mid-cycle), estrogen levels rise, causing the cervical mucus to become more abundant, clear, and stretchy (often described as resembling raw egg whites). This "fertile" mucus facilitates the movement of sperm through the cervix and into the uterus, increasing the chances of fertilization.

As the menstrual cycle progresses and progesterone levels rise after ovulation, cervical mucus becomes thicker, cloudier, and less abundant, making it more difficult for sperm to penetrate. This change in cervical mucus helps prevent additional sperm from entering and fertilizing an already-fertilized egg.

Changes in cervical mucus can be used as a method of natural family planning or fertility awareness, with women checking their cervical mucus daily to identify their most fertile days. However, this method should be combined with other tracking methods for increased accuracy and reliability.

Bacterial RNA refers to the genetic material present in bacteria that is composed of ribonucleic acid (RNA). Unlike higher organisms, bacteria contain a single circular chromosome made up of DNA, along with smaller circular pieces of DNA called plasmids. These bacterial genetic materials contain the information necessary for the growth and reproduction of the organism.

Bacterial RNA can be divided into three main categories: messenger RNA (mRNA), ribosomal RNA (rRNA), and transfer RNA (tRNA). mRNA carries genetic information copied from DNA, which is then translated into proteins by the rRNA and tRNA molecules. rRNA is a structural component of the ribosome, where protein synthesis occurs, while tRNA acts as an adapter that brings amino acids to the ribosome during protein synthesis.

Bacterial RNA plays a crucial role in various cellular processes, including gene expression, protein synthesis, and regulation of metabolic pathways. Understanding the structure and function of bacterial RNA is essential for developing new antibiotics and other therapeutic strategies to combat bacterial infections.

Chlamydiae.com "Chlamydia trachomatis". NCBI Taxonomy Browser. 813. Type strain of Chlamydia trachomatis at BacDive - the ... Chlamydia trachomatis (/kləˈmɪdiə trəˈkoʊmətɪs/), commonly known as chlamydia, is a bacterium that causes chlamydia, which can ... trachomatis. In the 1990s it was shown that there are several species of Chlamydia. Chlamydia trachomatis was first described ... "Chlamydia trachomatis". Retrieved 2015-11-18.[dead link] Elwell C, Mirrashidi K, Engel J (2016). "Chlamydia cell biology and ...
Chlamydia trachomatis: 5 days after birth to 2 weeks (late onset - C. trachomatis has a longer incubation period) Untreated ... "Chlamydia trachomatis". In: Red Book: 2015 Report of the Committee on Infectious Diseases, 30th, Kimberlin DW (Ed), Elk Grove ... most commonly Neisseria gonorrhoeae or Chlamydia trachomatis. Antibiotic ointment is typically applied to the newborn's eyes ... Babies infected with chlamydia may develop pneumonitis (chest infection) at a later stage (range 2-19 weeks after delivery). ...
"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39". Nucleic Acids Research. 28 (6): 1397-1406. doi: ... trachomatis and Ch. pneumoniae are orthologs. Adapted after Read et al. 2000 Chlamydia may be found in the form of an ... Species include Chlamydia trachomatis (a human pathogen), Ch. suis (affects only swine), and Ch. muridarum (affects only mice ... "Chlamydia trachomatis". Archived from the original on July 2, 2010. Retrieved June 18, 2010. Everett KD, Bush RM, Andersen AA ( ...
In the UK it is reported by the NHS that infections by Neisseria gonorrhoeae and Chlamydia trachomatis are responsible for only ... While it has been reported that infections by Neisseria gonorrhoeae or Chlamydia trachomatis are present in 75 to 90 percent of ... Chlamydia trachomatis Neisseria gonorrhoeae Prevotella spp. Streptococcus pyogenes Prevotella bivia Prevotella disiens ... Chlamydia trachomatis and Neisseria gonorrhoeae are common causes of PID. However, PID can also be caused by other untreated ...
Miller KE (April 2006). "Diagnosis and treatment of Chlamydia trachomatis infection". Am Fam Physician. 73 (8): 1411-6. PMID ...
Haemophilus influenzae and Chlamydia trachomatis are coccobacilli. Aggregatibacter actinomycetemcomitans is a gram negative ...
... or L3 of Chlamydia trachomatis. LGV is primarily an infection of lymphatics and lymph nodes. Chlamydia trachomatis is the ... Spaargaren J, Fennema HS, Morré SA, de Vries HJ, Coutinho RA (July 2005). "New lymphogranuloma venereum Chlamydia trachomatis ... Schaeffer A; Henrich B (2008). "Rapid detection of Chlamydia trachomatis and typing of the lymphogranuloma venereum associated ... anorectal Chlamydia trachomatis serovar L2b in men who have sex with men". Journal of Clinical Microbiology. 45 (3): 1029-31. ...
"Comparative genomes of Chlamydia pneumoniae and C. trachomatis". Nature Genetics. 21 (4): 385-9. doi:10.1038/7716. PMID ... Chlamydia pneumoniae is a species of Chlamydia, an obligate intracellular bacterium that infects humans and is a major cause of ... Chlamydia pneumoniae has also been found in the cerebrospinal fluid of patients diagnosed with multiple sclerosis. Chlamydia ... Chlamydia pneumoniae has a complex life cycle and must infect another cell to reproduce; thus, it is classified as an obligate ...
Common bacterial causes for this disease are Chlamydia trachomatis and Neisseria gonorrhoeae. Lee Goldman; Andrew I. Schafer ( ... "Chlamydia trachomatis infection in Fitz-Hugh-Curtis syndrome". American Journal of Obstetrics and Gynecology. 138 (7 Pt 2): ...
Yu, Jialin; Wu, Shixiao; Li, Fang; Hu, Linyan (2009). "Vertical Transmission of Chlamydia trachomatis in Chongqing China". ... Neisseria gonorrhoeae and Chlamydia trachomatis), and normal fauna of the genitourinary tract (e.g., Candida albicans) are ... Chlamydia HIV Human T-lymphotropic virus Syphilis Zika fever, caused by Zika virus, can cause microcephaly and other brain ... Chlamydia infection, Ureaplasma urealyticum, and human papillomavirus) S - Syphilis The signs and symptoms of a vertically ...
Bakken IJ (February 2008). "Chlamydia trachomatis and ectopic pregnancy: recent epidemiological findings". Current Opinion in ... The risk of ectopic pregnancy after chlamydia infection is low. The exact mechanism through which chlamydia increases the risk ... Prevention is by decreasing risk factors such as chlamydia infections through screening and treatment. While some ectopic ... Risk factors for ectopic pregnancy include pelvic inflammatory disease, often due to chlamydia infection; tobacco smoking; ...
Chlamydia trachomatis may increase the risk of miscarriage. Toxoplasmosis can cause a miscarriage. Subclinical infections of ... chlamydia, gonorrhoea, syphilis, and malaria. Autoimmunity is a possible cause of recurrent or late-term miscarriages. In the ...
Less commonly, Chlamydia spp. may be the cause. Bacteria such as Chlamydia trachomatis or Moraxella spp. can cause a ... Inclusion conjunctivitis of the newborn is a conjunctivitis that may be caused by the bacterium Chlamydia trachomatis, and may ... People who wear contact lenses and those whose infection is caused by gonorrhea or chlamydia should be treated. Allergic cases ... have disease which is thought to be due to chlamydia or gonorrhea, have a fair bit of pain, or have copious discharge. ...
Yasin B, Harwig SS, Lehrer RI, Wagar EA (March 1996). "Susceptibility of Chlamydia trachomatis to protegrins and defensins". ...
Wan, F. Y.; Enciso, G. A. (2017). "Optimal Proliferation and Differentiation of Chlamydia Trachomatis - PMC". Studies in ... Enciso, G.A., Sütterlin, C., Tan, M. and Wan, F.Y.M. (2022). Stochastic Chlamydia dynamics and optimal spread, Bull. Math. Biol ... Enciso, German; Sütterlin, Christine; Tan, Ming; Wan, Frederic Y. M. (February 17, 2021). "Stochastic Chlamydia Dynamics and ... the life cycle of the infectious disease Chlamydia to the bacteria's drive for competitive survival shows the utility of (the ...
... chlamydia trachomatis screening); neurology (Guillain Barré syndrome, stroke); and traumatic brain injury (prognosis and ...
Testing pregnant women for Group B Streptococcus and Chlamydia trachomatis, and administering antibiotic treatment, if needed, ... Darville T (October 2005). "Chlamydia trachomatis infections in neonates and young children". Seminars in Pediatric Infectious ... Exposure to birds is associated with Chlamydia psittaci; farm animals with Coxiella burnetti; aspiration of stomach contents ... Mycoplasma, Legionella, Streptococcus, and Chlamydia can also be detected using PCR techniques on bronchoalveolar lavage and ...
Diener-West, Marie (1998). "Incident Chlamydia trachomatis Infections Among Inner-city Adolescent Females". JAMA. 280 (6): 521- ... Burstein, Gale R. (1998). "JAMA Network , JAMA , Incident Chlamydia trachomatis Infections Among Inner-city Adolescent Females ...
and Chlamydia trachomatis from the mother to the newborn". Archives of Gynecology and Obstetrics. 241 (3): 165-170. doi:10.1007 ...
Haemophilus influenzae, Gardnerella vaginalis, and Chlamydia trachomatis are coccobacilli. Aggregatibacter ...
April 2005). "Chlamydia trachomatis and Neisseria gonorrhoeae prevalence and coinfection in adolescents entering selected US ... Trebach JD, Chaulk CP, Page KR, Tuddenham S, Ghanem KG (May 2015). "Neisseria gonorrhoeae and Chlamydia trachomatis among women ... Ljubin-Sternak S, Meštrović T (2014). "Chlamydia trachomatis and Genital Mycoplasmas: Pathogens with an Impact on Human ... "Home-based versus clinic-based specimen collection in the management of Chlamydia trachomatis and Neisseria gonorrhoeae ...
... or more specifically a chlamydia infection, is a sexually transmitted infection caused by the bacterium Chlamydia trachomatis. ... Chlamydia is known as the "silent epidemic", as at least 70% of genital C. trachomatis infections in women (and 50% in men) are ... Infection by the bacterium Chlamydia trachomatis only occurs in humans. Diagnosis is often by screening which is recommended ... Chlamydia can be spread during vaginal, anal, or oral sex, and can be passed from an infected mother to her baby during ...
"Arlt's syndrome": A contagious eye infection caused by Chlamydia trachomatis. "Arlt's triangle": keratic precipitates ... Linear scar present in sulcus subtarsalis during Chlamydia trachomatis infection. "Arlt's operation": Transplantation of ...
... is caused by Chlamydia trachomatis, serotypes (serovars) A, B, and C. It is spread by direct contact with eye, nose, ... Trachoma is an infectious disease caused by bacterium Chlamydia trachomatis. The infection causes a roughening of the inner ... "Chlamydia trachomatis infection of the male genital tract: An update". Journal of Reproductive Immunology. 100 (1): 37-53. doi: ... Antibiotic treatment reduces the risk of active trachoma in individuals infected with chlamydial trachomatis. For individuals ...
Tong CY, Mallinson H (May 2002). "Moving to nucleic acid-based detection of genital Chlamydia trachomatis". Expert Review of ... Molecular diagnostics are used to identify infectious diseases such as chlamydia, influenza virus and tuberculosis; or specific ...
2001). Chlamydia trachomatis cytotoxicity associated with complete and partial cytotoxin genes. Proc. Natl. Acad. Sci. USA 98: ...
Tubal factor is one complication of Chlamydia trachomatis infection in women. Sexually transmitted Chlamydia and genital ... Tubal factor infertility can be due to Chlamydia infection and testing for Chlamydia antibodies is one diagnostic tool. A ... Infertility can have multiple possible causes and may not be recognized for years after a gonorrhea, Chlamydia or Mycoplasma ... Ljubin-Sternak, Suncanica; Mestrovic, Tomislav (2014). "Review: Chlamydia trachonmatis and Genital Mycoplasmias: Pathogens with ...
Some examples of evidence-based research on chlamydia include: Chlamydia trachomatis and Genital Mycoplasmas: Pathogens with an ... This facility is developing a vaccine to prevent Chlamydia trachomatis infection. The vaccine being tested is a single- ... Ljubin-Sternak, S; Meštrović, T (2014). "Chlamydia trachomatis and Genital Mycoplasmas: Pathogens with an Impact on Human ... Chlamydia research is the systematic study of the organisms in the taxonomic group of bacteria Chlamydiota (formerly Chlamydiae ...
2000). "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39". Nucleic Acids Res. 28 (6): 1397-406. doi ... 1999). "Comparative genomes of Chlamydia pneumoniae and C. trachomatis". Nat Genet. 21 (4): 385-9. doi:10.1038/7716. PMID ... 1998). "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis". Science. 282 (5389): 754-9. ... 2005). "Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains". Infection and Immunity. 73 ...
Allen, Judith (1991). The cysteine-rich proteins of Chlamydia trachomatis in structure and immunity. berkeley.edu (PhD thesis ... where her PhD investigated cysteine-rich proteins of Chlamydia trachomatis. Allen spent several years in the biotechnology ...
PATIENT CARE: AN EXPANDED ROLE FOR THE USE OF CHLAMYDIA TESTS The Chlamydia trachomatis infections policy guidelines published ... Comparison of the Clearview Chlamydia test, Chlamydiazyme, and cell culture for detection of Chlamydia trachomatis in women ... The test methodologies discussed in these recommendations are for the detection of Chlamydia trachomatis -- not other chlamydia ... trachomatis. Alternative antibodies used to stain chlamydia inclusions that bind to chlamydia lipopolysaccharide (LPS) are NOT ...
PATIENT CARE: AN EXPANDED ROLE FOR THE USE OF CHLAMYDIA TESTS. The Chlamydia trachomatis infections policy guidelines published ... Comparison of the Clearview Chlamydia test, Chlamydiazyme, and cell culture for detection of Chlamydia trachomatis in women ... The test methodologies discussed in these recommendations are for the detection of Chlamydia trachomatis -- not other chlamydia ... trachomatis. Alternative antibodies used to stain chlamydia inclusions that bind to chlamydia lipopolysaccharide (LPS) are NOT ...
Chlamydiae.com "Chlamydia trachomatis". NCBI Taxonomy Browser. 813. Type strain of Chlamydia trachomatis at BacDive - the ... Chlamydia trachomatis (/kləˈmɪdiə trəˈkoʊmətɪs/), commonly known as chlamydia, is a bacterium that causes chlamydia, which can ... trachomatis. In the 1990s it was shown that there are several species of Chlamydia. Chlamydia trachomatis was first described ... "Chlamydia trachomatis". Retrieved 2015-11-18.[dead link] Elwell C, Mirrashidi K, Engel J (2016). "Chlamydia cell biology and ...
... Genitourin Med. 1987 Jun;63(3):179-81. doi: 10.1136/sti.63.3. ...
Chlamydia trachomatis as possible cause of peritonitis and perihepatitis in young women. Br Med J 1978; 1 :1022 doi:10.1136/bmj ... Chlamydia trachomatis as possible cause of peritonitis and perihepatitis in young women. ... Chlamydia trachomatis as possible cause of peritonitis and perihepatitis in young women. ... nine had serological evidence of recent infection with Chlamydia trachomatis; In five of these nine patients high antibody ...
... explains the mechanisms by which the bacterium Chlamydia trachomatis hijacks nutrients of its host to its own benefit. ... How Chlamydia trachomatis hijacks energy stores from its host. Human cells infected with Chlamydia trachomatis. © Institut ... Chlamydia trachomatis is also able to colonize the eye, and the resulting inflammation is the leading cause of blindness by an ... In the case of Chlamydia trachomatis, it is known that the vacuole is rich in glycogen, an energy storage molecule made of ...
Timeline for Species Chlamydia trachomatis [TaxId:813] from a.25.1.2 Ribonucleotide reductase R2: *Species Chlamydia ... called Species Chlamydia trachomatis from a.25.1.2 Ribonucleotide reductase R2. *Species Chlamydia trachomatis [TaxId:813] from ... PDB entry in Species: Chlamydia trachomatis [TaxId: 813]:. *Domain(s) for 1syy: *. Domain d1syya_: 1syy A: [106126]. complexed ... Lineage for Species: Chlamydia trachomatis [TaxId: 813]. *Root: SCOPe 2.08 *. Class a: All alpha proteins [46456] (290 folds). ...
Darville, T, & Rours, G.I.J.G. (2012). Chlamydia trachomatis. doi:10.1016/B978-1-4377-2702-9.00169-0 ...
Establishing methods for protein purification and activity analysis for Pkn1 and Pkn5 from Chlamydia trachomatis. Hatfield, ...
Analysis of the cellular function of type III secretion effectors of Chlamydia trachomatis). Chlamydia trachomatis are obligate ... Analysis of the cellular function of type III secretion effectors of Chlamydia trachomatis. ... trachomatis infected cells.. To study the function of known effectors, we focused on the C. trachomatis Inc proteins, an ... trachomatis virulence. For this, specifically we aimed to (i) identify novel C. trachomatis type III secretion (T3S) effectors ...
Scientific Video Article | 우리는 화학 돌연변이 및 전체 게놈 시퀀싱에 따라 클라미디아의 유전자 분석을 수행하는 방법을 설명합니다. 또한, 감염된 세포 내에서 DNA 교환을위한 시스템은 유전자 매핑에 사용할 수있는 설명합니다. 이 방법은 변환 시스템...
Positive Serology for Chlamydia: Is It Always for Chlamydia trachomatis? Subject Area: Further Areas , Womens and Childrens ... Zvi Katz, Rony Levy, Samuel Lurie; Positive Serology for Chlamydia: Is It Always for Chlamydia trachomatis?. Gynecol Obstet ... In this study we tried to determine the factual prevalence of Chlamydia trachomatis seropositive women. Sera of 174 sexually ... We conclude that the currently used IPA method for chlamydia diagnosis overestimates C. trachomatis infection and its ...
Chlamydia trachomatis,/i,, or ,i,Trichomonas vaginalis,/i,. A remark on the intensity of inflammation should be made in the ... Chlamydia trachomatis,/i, 10.6%, ,i,Trichomonas vaginalis,/i, 10.6%, ,i,Mycoplasma hominis,/i, 8.5%, ,i, ... Chlamydia trachomatis,/i,, ,i,Neisseria gonorrhoeae,/i,, ,i,Mycoplasma genitalium,/i,, ,i,Trichomonas vaginalis,/i,, ,i, ... 3.2.2. Chlamydia trachomatis. Chlamydia trachomatis was the sole detected pathogen by multiplex PCR in three samples (samples 7 ...
C trachomatis detection. The chlamydia status of all specimens was determined using a previously published method.2 The PCR was ... Lister N A, Tabrizi S N, Fairley C K, et al. Validation of Roche Cobas Amplicor assay for detection of Chlamydia trachomatis in ... Schachter J, Chow J M, Howard H, et al. Detection of Chlamydia trachomatis by nucleic acid amplification testing: our ... Objectives: To assess the reliability of different laboratory methods for the detection of Chlamydia trachomatis in rectal ...
Background Chlamydial inclusion conjunctivitis caused by genital serovars of Chlamydia trachomatis (CT) is well-recognised, and ...
New research on Chlamydia trachomatis from the other side of the world and the UNC Pediatric Infectious Diseases program were ... has studied the pathogenesis of genital tract disease due to Chlamydia trachomatis for many years. C. trachomatis is a sexually ... New research on Chlamydia trachomatis from the other side of the world and the UNC Pediatric Infectious Diseases program were ... New research on Chlamydia trachomatis from the other side of the world and the UNC Pediatric Infectious Diseases program was ...
... trachomatis among asymptomatic men. Studies were categorized as three types: (a) non-STD clinic venues where men were ... Acceptability of urine-based screening for Chlamydia trachomatis in asymptomatic young men: a systematic review Sex Transm Dis ... trachomatis among asymptomatic men. Studies were categorized as three types: (a) non-STD clinic venues where men were ... Chlamydia Infections / microbiology * Chlamydia Infections / physiopathology* * Chlamydia trachomatis / isolation & ...
Our Chlamydia Trachomatis organisms come in various options for you to choose from. Browse our Chlamydia Trachomatis external ... Chlamydia Trachomatis Organisms. Chlamydia trachomatis refers to a Gram-negative bacterium that can cause chlamydia. Chlamydia ... ZeptoMetrix offers a comprehensive suite of Chlamydia trachomatis products including but not limited to Chlamydia trachomatis ... control options-such as multiple Chlamydia trachomatis external run control products-and Chlamydia trachomatis organism options ...
C. trachomatis only replicates from inside a host cell, and has evolved to acquire a variety of nutrients directly from its ... Thus, it is thought that the success of C. trachomatis as a human pathogen may lie in its ability to survive these ... This mode of growth is known as persistence and how C. trachomatis senses stress and responds in this manner is an important ... Our results suggest a mechanism by which Chlamydia can tailor its growth rate to the conditions within the host cell. The ...
Free, official info about 2015 ICD-9-CM diagnosis code 099.55. Includes coding notes, detailed descriptions, index cross-references and ICD-10-CM conversion info.
Adult Centers For Disease Control And Prevention (U.S.) Chlamydia Infections Chlamydia Trachomatis Female Health Occupations ... Chlamydia trachomatis infections : policy guidelines for prevention and control. Centers for Disease Control (U.S.) "Chlamydia ... Title : Chlamydia trachomatis infections : policy guidelines for prevention and control Corporate Authors(s) : Centers for ... Centers for Disease Control (U.S.) "Chlamydia trachomatis infections : policy guidelines for prevention and control" , 1985. ...
RealLine Chlamydia trachomatis / Neisseria gonorrhoeae" assay kit is intended for the detection of Chlamydia trachomatis and ... Chlamydia trachomatis is a Gram-negative, ovoid, non-motile bacterium from the genus Chlamydia. It is an obligate intracellular ... Sensitivity of Chlamydia trachomatis DNA detection was evaluated on a collection of 415 clinical samples: 200 urine samples ( ... As some C. trachomatis isolates are reported not to carry cryptic plasmid or have deletion(s) in it [7], "RealLine Chlamydia ...
A broad-spectrum cloning vector that exists as both an integrated element and a free plasmid in Chlamydia trachomatis Public ... A broad-spectrum cloning vector that exists as both an integrated element and a free plasmid in Chlamydia trachomatis. PLoS ONE ... We explored the utility of a broad host-range plasmid, pBBR1MCS-4, to transform chlamydiae, with a goal of simplifying the ... Plasmid transformation of chlamydiae has created new opportunities to investigate host-microbe interactions during chlamydial ...
The concern of the study is whether a Chlamydia infection at inclusion indicates an increased risk for Chlamydia at follow-up ... reproductive health and history of Chlamydia, and condom use. Chlamydia tests were performed by self-sampled specimens, ... A mutated Chlamydia, nvCT, has contributed to the increase. The occurrence of repeat infections is not investigated in Sweden. ... Patients positive for Chlamydia were retested 4 weeks after treatment. Contact tracing covered sexual contacts during the last ...
... we are looking for a Post-doc fellow in the field of Chlamydia trachomatis pathogenesis and tubal fibrosis within a 3D in vitro ... At CTR, we are looking for a Post-doc fellow in the field of Chlamydia trachomatis pathogenesis and tubal fibrosis within a 3D ... A strong plus will be past experience working with Chlamydia trachomatis or similar microbes and it is advisable to have a ... The post-doc will work on further using the 3D oviduct model to study tubal pathology, specifically Chlamydia trachomatis (CT) ...
Access Chlamydia Trachomatis Infection case definitions; uniform criteria used to define a disease for public health ... Chlamydia Trachomatis Infection , 2010 Case Definition. Related Condition(s). *Chlamydia trachomatis, genital infections ...
15163 - Anti-Chlamydia trachomatis LPS Antibody - Clone CL13-256.2.1 - Isotype IgM. 15171 - Anti-Chlamydia trachomatis LPS ... 15173 - Anti-Chlamydia trachomatis LPS Antibody - Clone CL19-158.1.3 - Isotype IgG2a. 15174 - Anti-Chlamydia trachomatis LPS ... Product Name Anti-Chlamydia trachomatis LPS Antibody (15172). Description Anti-Chlamydia trachomatis LPS Mouse Monoclonal ... Specificity These antibodies recognize LPS of Chlamydia trachomatis serovars A, B, Ba, C, D, E, F, G, H, I, J, K, L1, L2, L3. ...
Chlamydia trachomatis. C trachomatis colonizes the genital tracts of 2-13% of pregnant women (with higher rates among unmarried ... Chlamydia trachomatis and respiratory disease in infants. Med J Aust. 1981 Oct 3. 2(7):328-30. [QxMD MEDLINE Link]. ... Chlamydia trachomatis Screening and Treatment in Pregnancy to Reduce Adverse Pregnancy and Neonatal Outcomes: A Review. Front ... Robinson JL, Meier K, Lee BE, Larke B. Could urine be useful for the diagnosis of Chlamydia trachomatis pneumonia in infancy?. ...
Purified elementary bodies from Chlamydia trachomatis Cross Reactivity. Serovar specific, no known cross-reaction with other ...
  • In 1985, CDC published Policy Guidelines for Prevention and Control of Chlamydia trachomatis infections (1). (cdc.gov)
  • Those guidelines highlighted the prevalence and morbidity of chlamydial infections and stressed the need to include antibiotics effective against chlamydia when treating patients for urethritis, mucopurulent cervicitis, and pelvic inflammatory disease. (cdc.gov)
  • Because chlamydial infections are common among adolescents and young adults throughout the United States, health-care providers and other agencies serving these groups should become more involved if a sufficiently large proportion of the chlamydia-infected population is to be reached. (cdc.gov)
  • Chlamydia trachomatis infections are common in sexually active adolescents and young adults in the United States (CDC, unpublished review). (cdc.gov)
  • Chlamydia trachomatis are obligate intracellular bacterial pathogens that cause ocular and genital infections, which are a significant public health concern worldwide. (europa.eu)
  • A better understanding of C. trachomatis basic biology is important to eventually develop new ways to combat infections caused by these bacteria. (europa.eu)
  • The young women have the highest prevalence of genitourinary C. trachomatis infections. (roboscreen.com)
  • Neonates born of infected mothers can develop inclusion conjunctivitis, nasopharyngeal infections and pneumonia due to C. trachomatis [5]. (roboscreen.com)
  • The concern of the study is whether a Chlamydia infection at inclusion indicates an increased risk for Chlamydia at follow-up after 6-8 months, gender-specific risk factors for and clinical presentation of repeat infections. (biomedcentral.com)
  • Batteiger BE, Tan M. Chlamydia trachomatis (trachoma and urogenital infections). (medlineplus.gov)
  • Chlamydia trachomatis and Neisseria gonorrhoeae infections in the rectum and pharynx are important extragenital reservoirs of infection. (escholarship.org)
  • These analytical performance data demonstrate that the Abbott CT/NG RealTime assay is an accurate, sensitive, and specific assay in rectal and pharyngeal specimens, supporting the potential of the assay for detection of rectal and pharyngeal C. trachomatis and N. gonorrhoeae infections. (escholarship.org)
  • Unfortunately, they have been facing a serious health crisis in recent years due to an epidemic of chlamydia infections. (chlamydiatrachomatis.com)
  • Chlamydia is one of the most common sexually transmitted infections (STIs) in the United States, and is particularly common among young people. (chlamydiatrachomatis.com)
  • One hundred thirty million Chlamydia trachomatis infections are reported worldwide each year. (analesdepediatria.org)
  • Nucleic acid amplification testing (NAAT) is the recommended method for initial screening or testing for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infections. (publichealthontario.ca)
  • Bacterial infections include chlamydia, gonorrhea, and syphilis. (virtualpsychcentre.com)
  • Chlamydiae are obligate intracellular bacteria responsible for pulmonary infections, ocular trachoma, sexually transmitted diseases, and infections of the genital tract in the pediatric and adult population. (unboundmedicine.com)
  • The IgG antibody detection is a marker for a Chlamydia-positive immune response, either for current, chronic, or past infections. (orangehealth.in)
  • This test helps mainly in diagnosing a chlamydia infection caused by Chlamydia is one of the most commonly found bacterial sexually transmitted infections and may lead to serious complications like a pelvic inflammatory disease in women, infertility, increased risk of tubal pregnancy, which may be fatal, etc. if it is left untreated. (orangehealth.in)
  • Three species of Chlamydia cause human disease, including sexually transmitted infections and respiratory infections. (msdmanuals.com)
  • 8 found that chlamydia and trichomoniasis infections were This suggests a persistently high prevalence of STIs, common among pregnant women (30.9% and 20.8%, particularly chlamydia, for the past decade. (who.int)
  • 4 Chlamydia infections are are needed to inform intervention design. (who.int)
  • Over the course of the C. trachomatis life cycle, the bacteria take on two distinct forms. (wikipedia.org)
  • The C. trachomatis genome is substantially smaller than that of many other bacteria at approximately 1.04 megabases, encoding approximately 900 genes. (wikipedia.org)
  • C. trachomatis are bacteria in the genus Chlamydia, a group of obligate intracellular parasites of eukaryotic cells. (wikipedia.org)
  • 1782 rectal specimens confirmed as C trachomatis positive using a standard laboratory method, were forwarded to the Sexually Transmitted Bacteria Reference Laboratory (STBRL). (bmj.com)
  • In order to ascertain the reproducibility of laboratory methods for the detection of C trachomatis in rectal sites, we examined the correlation between real time PCR results obtained at the reference laboratory, the Sexually Transmitted Bacteria Reference Laboratory (STBRL), and the methods used to determine the positive C trachomatis status of the specimen at the referring centre. (bmj.com)
  • Trachoma is an infection of the eye caused by bacteria called chlamydia. (medlineplus.gov)
  • Trachoma is caused by infection with the bacteria Chlamydia trachomatis . (medlineplus.gov)
  • In addition, unlike other bacteria, ' C. trachomatis' was unable to regulate transcription of central metabolism genes in response to type or amount of carbon found in its growth environment. (umanitoba.ca)
  • Chlamydia is a sexually transmitted infection caused by bacteria. (virtualpsychcentre.com)
  • What bacteria causes Chlamydia trachomatis? (virtualpsychcentre.com)
  • It is caused by bacteria called Chlamydia trachomatis . (virtualpsychcentre.com)
  • Is chlamydia a virus or bacteria? (virtualpsychcentre.com)
  • This test looks for Chlamydia trachomatis bacteria in a sample of cells collected by your doctor. (bartonhealth.org)
  • C. trachomatis bacteria cause chlamydia, the most common sexually transmitted disease (STD) in the U.S. (bartonhealth.org)
  • A positive result means that chlamydia bacteria were found and that you are likely infected with the disease. (bartonhealth.org)
  • Chlamydia is a genus of pathogenic bacteria that are obligate intracellular parasites. (cupidshealth.com)
  • Additionally, we will delve into the topic of Chlamydia trachomatis gram stain, a diagnostic test used to identify the presence of the bacteria. (watchdoq.com)
  • If you test positive for chlamydia, it means that you have been infected with the bacteria that causes the infection. (watchdoq.com)
  • Chlamydiae are nonmotile, obligate intracellular bacteria. (msdmanuals.com)
  • C. trachomatis along with C. pneumoniae have been found to infect humans to a greater extent. (wikipedia.org)
  • C. trachomatis in the lungs presents as the chlamydia pneumoniae respiratory infection and can affect all ages. (wikipedia.org)
  • The SPEIA test identified 41 (33.6%) of those as positive for C. trachomatis and 81 (66.4%) positive for C. pneumoniae . (karger.com)
  • By using the SPEIA test, it is possible to distinguish between C. trachomatis and C. pneumoniae seropositivity. (karger.com)
  • There are three main species of Chlamydia causing human infection: Chlamydia trachomatis, Chlamydia pneumoniae (also known as Chlamydophila pneumoniae), and Chlamydia psittacci. (virtualpsychcentre.com)
  • They include the genera Chlamydia (of which the type species is Chlamydia trachomatis) and Chlamydophila (eg, Chlamydophila pneumoniae and Chlamydophila psittaci). (virtualpsychcentre.com)
  • Genus specific (C. trachomatis, C. pneumoniae & C. psittaci). (idhinhibitor.com)
  • Chlamydia pneumoniae and, in recent studies, Chlamydia trachomatis , may not only induce asthma exacerbations but may also be involved in the pathogenesis of chronic asthma. (medscape.com)
  • The aim of this study was to describe the most common cytological features in cervical pap smears of patients with Chlamydia trachomatis , Neisseria gonorrhoeae , Mycoplasma genitalium , Trichomonas vaginalis , Mycoplasma hominis , Ureaplasma urealyticum , and Ureaplasma parvum detected by multiplex PCR. (hindawi.com)
  • Ureaplasma parvum 14.9%, Chlamydia trachomatis 10.6%, Trichomonas vaginalis 10.6%, Mycoplasma hominis 8.5%, Ureaplasma urealyticum 4.2%, Neisseria gonorrhoeae 2.1%, and Mycoplasma genitalium (0). (hindawi.com)
  • As some C. trachomatis isolates are reported not to carry cryptic plasmid or have deletion(s) in it [7], "RealLine Chlamydia trachomatis/ Neisseria gonorrhoeae" assay kit detects two DNA fragments from gyrA gene and cryptic plasmid, specific to C. trachomatis species. (roboscreen.com)
  • RealLine Chlamydia trachomatis / Neisseria gonorrhoeae" assay kit detects a part of PivNG (pilin gene inverting protein homolog) gene sequence, specific to N. gonorrhoeae . (roboscreen.com)
  • RealLine Chlamydia trachomatis / Neisseria gonorrhoeae" assay kit is intended for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae DNA in human specimens: urine, semen, prostate fluid, swabs of the epithelial cells (urethral, cervical, vaginal), using the method of real-time polymerase chain reaction (PCR) with fluorescence detection of amplified product. (roboscreen.com)
  • Analytical Evaluation of the Abbott RealTime CT/NG Assay for Detection of Chlamydia trachomatis and Neisseria gonorrhoeae in Rectal and Pharyngeal Swabs. (escholarship.org)
  • The positive C trachomatis status of all the specimens was confirmed upon receipt using a plasmid based in-house real time polymerase chain reaction (PCR) method which detects all serovars of C trachomatis before genotyping. (bmj.com)
  • Inclusivity was performed against 12 serovars of C. trachomatis and seven strains of N. gonorrhoeae. (escholarship.org)
  • Description: A sandwich ELISA for quantitative measurement of Rat anti Chlamydia trachomatis,CT antibody IgG in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (cdna-clone.com)
  • Description: Qualitative indirect ELISA kit for measuring Human anti-Chlamydia trachomatis (CT) antibody (IgG) in samples from serum. (cdna-clone.com)
  • The Chlamydia Trachomatis Antibody IgG test: Analyzes the levels of anti-chlamydia antibodies IgG in the blood. (orangehealth.in)
  • Chlamydia trachomatis, commonly known as chlamydia, is one of four bacterial species in the genus Chlamydia. (cupidshealth.com)
  • Host Genetic Risk Factors for Chlamydia trachomatis-Related Infertility in Women. (bvsalud.org)
  • Chlamydia trachomatis (Ct) infection ascending to the upper genital tract can cause infertility . (bvsalud.org)
  • Chlamydia is a bacterial infection that can cause serious health problems in koalas, including blindness, infertility, and death. (chlamydiatrachomatis.com)
  • In women, chlamydia can also cause pelvic inflammatory disease, which can lead to infertility if left untreated. (watchdoq.com)
  • The Chlamydia Trachomatis IgG Antibody testing (CAT) has been used as a screening test for tubal factor infertility (TFI), but the CAT is only a marker of past exposure to Chlamydia. (orangehealth.in)
  • Nevertheless, recognizing the symptoms of chlamydia in males is important in order to receive prompt diagnosis and treatment. (chlamydiatrachomatis.com)
  • What are the Symptoms of Chlamydia in Men? (chlamydiatrachomatis.com)
  • What are 5 symptoms of chlamydia? (virtualpsychcentre.com)
  • Common Symptoms of Chlamydia Infection and How to Prevent It? (watchdoq.com)
  • If you are experiencing any symptoms of chlamydia, such as pain during urination or abnormal discharge, it is important to get tested and treated as soon as possible. (watchdoq.com)
  • A publication in eLife from researchers of the Institut Pasteur, CNRS, University of Lille and Indiana University (USA) explains the mechanisms by which the bacterium Chlamydia trachomatis hijacks nutrients of its host to its own benefit. (pasteur.fr)
  • Late Stage Chlamydia: Understanding the Consequences and Treatment Options Introduction: Late stage chlamydia, also known as chronic or persistent chlamydia, is a serious and often overlooked condition caused by the bacterium Chlamydia trachomatis. (chlamydiatrachomatis.com)
  • Chlamydia, or more specifically a chlamydia infection, is a sexually transmitted infection caused by the bacterium Chlamydia trachomatis. (virtualpsychcentre.com)
  • Trachoma is a devastating eye disease caused by infection with the bacterium Chlamydia trachomatis . (who.int)
  • We conclude that the currently used IPA method for chlamydia diagnosis overestimates C. trachomatis infection and its specificity for the diagnosis of C. trachomatis is limited. (karger.com)
  • A properly obtained negative C trachomatis culture indicates the absence of infection with 100% specificity. (medscape.com)
  • The current study reports on the analytical performance of the Abbott RealTime CT/NG assay, including the limit of detection, inclusivity, and analytical specificity for C. trachomatis and N. gonorrhoeae in rectal and pharyngeal specimens. (escholarship.org)
  • We still need to understand the advantage that glycogen accumulation brings to Chlamydia trachomatis, a pathogen that develop exclusively in humans. (pasteur.fr)
  • The Chlamydia Vaccine Initiative is a partnership of academic institutions and industry to explore systems-level host/pathogen molecular interactions during infection of the female genital tract by C. trachomatis and to develop a vaccine. (unchealthcare.org)
  • Chlamydia trachomatis is an obligate intracellular human pathogen that exhibits stage-specific gene transcription throughout a biphasic developmental cycle. (plos.org)
  • Thus, it is thought that the success of C . trachomatis as a human pathogen may lie in its ability to survive these immunological stress situations by slowing growth and development until conditions in the cell have improved. (plos.org)
  • The intracellular bacterial pathogen, Chlamydia trachomatis, is a tryptophan auxotroph. (duke.edu)
  • In five of these nine patients high antibody titres to chlamydiae were found without laboratory evidence of gonococcal infection, while the other four had evidence of simultaneous gonococcal infection. (bmj.com)
  • Chlamydia Antibody Laboratories manufactures the chlamydia trachomatis igg antibody reagents distributed by Genprice. (cdna-clone.com)
  • The Chlamydia Trachomatis Igg Antibody reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (cdna-clone.com)
  • Description: Qualitativeindirect ELISA kit for measuring Mouse Chlamydia trachomatis (CT) antibody (IgG) in samples from serum, plasma. (cdna-clone.com)
  • When is the Chlamydia Trachomatis Antibody IgG test recommended? (orangehealth.in)
  • The cost of the Chlamydia Trachomatis Antibody IgG test in Noida is Rs. (orangehealth.in)
  • How often should I get the Chlamydia Trachomatis Antibody IgG test? (orangehealth.in)
  • The Chlamydia Trachomatis Antibody IgG test is prescribed by your doctor after completing the assessment of your condition. (orangehealth.in)
  • What are the normal values for the Chlamydia Trachomatis Antibody IgG test? (orangehealth.in)
  • Is fasting required for a Chlamydia Trachomatis Antibody IgG test? (orangehealth.in)
  • Any other precautions to be taken before getting myself tested for a Chlamydia Trachomatis Antibody IgG test? (orangehealth.in)
  • How can I book a Chlamydia Trachomatis Antibody IgG test in Delhi? (orangehealth.in)
  • Why should I book a Chlamydia Trachomatis Antibody IgG test with Orange Health Labs in Delhi? (orangehealth.in)
  • citation needed] Clinical signs and symptoms of C. trachomatis infection in the genitalia present as the chlamydia infection, which may be asymptomatic or may resemble a gonorrhea infection. (wikipedia.org)
  • We performed a structured literature review of published studies from 2000-2007 that measured the acceptability and acceptance (uptake) of urine testing for C. trachomatis among asymptomatic men. (nih.gov)
  • Interventions to enhance uptake of testing in asymptomatic men should be developed and selected with underlying C. trachomatis population prevalence in mind. (nih.gov)
  • Chlamydia infection is usually asymptomatic in most women and many men. (orangehealth.in)
  • Lymphogranuloma Venereum (LGV) Lymphogranuloma venereum (LGV) is a disease caused by 3 unique strains of Chlamydia trachomatis and characterized by a small, often asymptomatic skin lesion, followed by regional lymphadenopathy. (msdmanuals.com)
  • C. trachomatis exclusively infects humans. (wikipedia.org)
  • The origins of both sexually transmitted and ocular C. trachomatis are unclear, but it seems likely that they evolved with humans and shared a common ancestor with environmental chlamydiae some 700 million years ago. (virtualpsychcentre.com)
  • abstract = "Cultures for Chlamydia trachomatis were obtained from 127 female adolescents (13-17 years of age) evaluated for reported sexual abuse. (umn.edu)
  • Like other Chlamydia species, the C. trachomatis life cycle consists of two morphologically distinct life stages: elementary bodies and reticulate bodies. (wikipedia.org)
  • Like other Chlamydia species, C. trachomatis has a life cycle consisting of two morphologically distinct forms. (wikipedia.org)
  • C. trachomatis is thought to have diverged from other Chlamydia species around 6 million years ago. (wikipedia.org)
  • Indeed, Chlamydia species that infect other hosts do not accumulate glycogen. (pasteur.fr)
  • To screen for novel T3S effectors of C. trachomatis, we used Yersinia enterocolitica as a genetically tractable surrogate bacterial species assembling a T3S apparatus, which has been shown to recognise heterologous T3S substrates. (europa.eu)
  • Plasmid transformation requires a replicon derived from the native Chlamydia plasmid, and these transformations are species-specific. (oregonstate.edu)
  • Dr. Toni Darville, Distinguished Professor of Pediatrics and Microbiology & Immunology and Scientific Director of the Children's Research Institute, has studied the pathogenesis of genital tract disease due to Chlamydia trachomatis for many years. (unchealthcare.org)
  • U urealyticum colonizes the genital tract of 40-80% of pregnant women (with risk factors similar to those for C trachomatis ) and the mucous membranes of 16% of newborns with low birthweight and 8-11% of infants who weigh more than 2500 g at birth. (medscape.com)
  • Adequate surveillance and treatment of C. trachomatis colonizing the genital tract of pregnant women is the best way of preventing disease in the infant. (unboundmedicine.com)
  • C. trachomatis is responsible for neonatal conjunctivitis, trachoma, pneumonia in young infants, genital tract infection, and LGV. (unboundmedicine.com)
  • In this study we tried to determine the factual prevalence of Chlamydia trachomatis seropositive women. (karger.com)
  • The results of this analysis confirm previously observed trends in Samoa for younger age groups' prevalence of chlamydia and gonorrhoea, and for older age groups' prevalence of hepatitis B and C. But the analysis also unexpectedly found that older age groups (aged 45 and above) are more likely to test positive for syphilis (for years 2014 and 2017). (who.int)
  • Chlamydia trachomatis is a Gram-negative, ovoid, non-motile bacterium from the genus Chlamydia . (roboscreen.com)
  • We report a case of co-infection of Mycoplasma genitalium and Chlamydia trachomatis in an infertile female patient with genital tuberculosis. (who.int)
  • ZeptoMetrix offers a comprehensive suite of Chlamydia trachomatis products including but not limited to Chlamydia trachomatis control options-such as multiple Chlamydia trachomatis external run control products-and Chlamydia trachomatis organism options. (zeptometrix.com)
  • The new Swedish variant of C trachomatis, which eluded NAATs, was detected because the organism could be cultured. (medscape.com)
  • In addition to the chromosome that contains most of the genome, nearly all C. trachomatis strains carry a 7.5 kilobase plasmid that contains 8 genes. (wikipedia.org)
  • C. trachomatis strains are generally divided into three biovars based on the type of disease they cause. (wikipedia.org)
  • Most C. trachomatis strains have a multicopy extrachromosomal cryptic plasmid, which is widely used as the target for PCR testing. (roboscreen.com)
  • C. trachomatis is the single most important infectious agent associated with blindness (trachoma), and it also affects the eyes in the form of inclusion conjunctivitis and is responsible for about 19% of adult cases of conjunctivitis. (wikipedia.org)
  • Ocular prophylaxis at birth does not reliably prevent C. trachomatis conjunctivitis or extraocular infection, even if erythromycin ointment is used. (unboundmedicine.com)
  • Trachoma Trachoma is a chronic conjunctivitis caused by Chlamydia trachomatis and is characterized by progressive exacerbations and remissions. (msdmanuals.com)
  • What It Means to Test Positive for Chlamydia Trachomatis? (watchdoq.com)
  • Although prevalence estimates were well established unmarried or are 18-24 years of age were more likely in previous studies, more recent data on sex and age to test positive for chlamydia. (who.int)
  • High rates of confirmation can be achieved using an independent real time PCR assay to examine rectal specimens which had initially tested C trachomatis positive using nucleic acid amplification tests and chlamydia tissue culture. (bmj.com)
  • 1 However, in the United Kingdom the testing of rectal specimens for Chlamydia trachomatis has been problematic for diagnostic laboratories because of the lack of a licensed nucleic acid amplification test (NAAT) platform for extragenital sites, a lack of culture facilities, and the continued and extensive use of enzyme immunoassay (EIA) methods. (bmj.com)
  • Criteria for inclusion in this analysis were that referral forms must state that a specimen was sourced from a rectal site and had tested positive for C trachomatis at the primary laboratory using a known and stated standard laboratory test. (bmj.com)
  • The limit of detection was performed using known concentrations of organisms, elementary bodies per milliliter (EB/mL) for C. trachomatis and colony-forming units per milliliter (CFU/mL) for N. gonorrhoeae, in clinical rectal and pharyngeal swab matrices. (escholarship.org)
  • The limit of detection for C. trachomatis was 2.56 EB/mL in pharyngeal specimens and 12.8 EB/mL in rectal specimens. (escholarship.org)
  • Chlamydia trachomatis may infect the anal/rectal canal of sexually active individuals. (geisingermedicallabs.com)
  • or Roche tests compared with counties that used the BD method was -9.5 % (95% CI -14.1 to -4.7, p = 0.0005), I after baseline differences and county differences in testing n 2006 a new variant of Chlamydia trachomatis (nvCT) were controlled for. (cdc.gov)
  • A mutated Chlamydia, nvCT, has contributed to the increase. (biomedcentral.com)
  • Chlamydia tests were performed by self-sampled specimens, analyzed by the ProbeTec (Becton Dickinson) method, Ct-positive specimens also analyzed with a nvCT-specific method. (biomedcentral.com)
  • The collected data will provide gender-specific information on the occurrence of and risk for repeat Chlamydia infection, the occurrence of nvCT, and clinical data and information on sexual behaviour and reproductive health, risk-taking and condom use. (biomedcentral.com)
  • In late 2006, a new variant of Chlamydia trachomatis (nvCT) was identified in Sweden [ 3 ]. (biomedcentral.com)
  • However, the increase of Chlamydia cases continues also when nvCT is included in testing systems used all over Sweden. (biomedcentral.com)
  • Until recently, chlamydia prevention and patient care were impeded by the lack of suitable laboratory tests for screening and diagnosis. (cdc.gov)
  • When diagnosis of C trachomatis is disputed, a culture should be performed. (medscape.com)
  • The diagnosis of Chlamydia was made by plasmid detection with an in-house PCR assay, and genotypes were identified using a PCR-RFLP assay for the ompA gene. (analesdepediatria.org)
  • Reiter's disease is the one established to be triggered by Chlamydia Trachomatis nongonococcal infection. (healthcaremagic.com)
  • 23-55% of all cases of nongonococcal urethritis in men are caused by C. trachomatis . (unboundmedicine.com)
  • C. trachomatis is the most common infectious cause of blindness and the most common sexually transmitted bacterium. (wikipedia.org)
  • Chlamydia is one of the most common sexually transmitted diseases worldwide. (roboscreen.com)
  • Chlamydia is a common sexually transmitted disease. (virtualpsychcentre.com)
  • In this article, we will explore various aspects of Chlamydia trachomatis, a common sexually transmitted infection caused by the bacterium of the same name. (watchdoq.com)
  • Chlamydia trachomatis is a common sexually transmitted infection that can cause serious health problems if left untreated. (watchdoq.com)
  • Ocular immune responses, chlamydia trachomatis infection and clinical signs of trachoma before and after azithromycin mass drug administration in a treatment naïve trachoma-endemic Tanzanian community. (medlineplus.gov)
  • Application Instructions These antibodies have been qualified for use in ELISA to detect Chlamydia trachomatis elementary bodies and reticulate bodies. (qedbio.com)
  • These include the use of NAATs to detect chlamydia. (medscape.com)
  • There are several other tests that could also be used to detect chlamydia. (orangehealth.in)
  • Detection of Chlamydia trachomatis from urine and male urethral swab specimens, female endocervical swabs, Thin Prep samples, and vaginal swab specimens. (marshfieldlabs.org)
  • In men, chlamydia can cause urethritis, a swelling of the urethra and possibly blood in the urine. (bartonhealth.org)
  • Chlamydia trachomatis is diagnosed through a simple urine test or a swab of the genital area. (watchdoq.com)
  • Chlamydiae are small gram-negative obligate intracellular microorganisms that preferentially infect squamocolumnar epithelial cells. (virtualpsychcentre.com)
  • Failure to identify an inflammatory agent in pap smear with intense neutrophil exudate may suggest the presence of Ureaplasma parvum , Ureaplasma urealyticum , Chlamydia trachomatis , or Trichomonas vaginalis . (hindawi.com)
  • Although many organisms can cause afebrile pneumonia syndrome (APS), this article focuses on Chlamydia trachomatis, cytomegalovirus (CMV), and Ureaplasma urealyticum, which are vertically transmitted to newborns during passage through the birth canal or, in the case of CMV, also during breastfeeding. (medscape.com)
  • The most commonly prescribed antibiotics for chlamydia are azithromycin and doxycycline. (watchdoq.com)
  • If left untreated, 5-13% of infants colonized by C trachomatis develop pneumonia. (medscape.com)
  • C. trachomatis can cause afebrile pneumonia in 10-20% of infants born to infected mothers. (unboundmedicine.com)
  • Chlamydia trachomatis (CT) is the most prevalent sexually transmitted bacterial infection, affecting mainly young, sexually active women. (ufrgs.br)
  • Chlamydia is a bacterial infection that requires prescription antibiotics to be effectively treated. (chlamydiatrachomatis.com)
  • Chlamydia is a bacterial infection that can cause a range of symptoms, including discharge, painful urination, and pelvic pain. (chlamydiatrachomatis.com)
  • Chlamydia trachomatis is a bacterial infection that is sexually transmitted. (watchdoq.com)
  • To study the function of known effectors, we focused on the C. trachomatis Inc proteins, an important group of potential chlamydial virulence factors. (europa.eu)
  • Thus, the plasmid can be successfully transformed into chlamydia without a chlamydial origin of replication and can exist in multiple states within a transformed population. (oregonstate.edu)
  • Information generated from these studies can be used towards the development of new treatments for chlamydial diseases and towards the development of a cell-free growth system for chlamydiae. (umanitoba.ca)
  • C trachomatis colonizes the genital tracts of 2-13% of pregnant women (with higher rates among unmarried women with lower socioeconomic status, a greater number of sexual partners, and younger age) and is transmitted to more than 50% of their infants. (medscape.com)
  • Odds ratio and 2 tests were conducted to compare the rates of positivity of chlamydia, gonorrhoea, hepatitis B and C, and syphilis across age groups from 2012 and 2017 surveillance data in Samoa. (who.int)
  • Samoa has historically reported high rates of chlamydia and gonorrhoea and low rates of HIV and syphilis from The 2017 national positivity rates for chlamydia, cross-sectional antenatal prevalence studies. (who.int)
  • Association between Chlamydia trachomatis genotypes and clinical features of the newborn. (analesdepediatria.org)
  • Differences in somatometric measurements and clinical variables in newborns with respiratory distress and infection between different Chlamydia trachomatis genotypes. (analesdepediatria.org)
  • We explored the utility of a broad host-range plasmid, pBBR1MCS-4, to transform chlamydiae, with a goal of simplifying the transformation process. (oregonstate.edu)
  • The plasmid was modified to contain chromosomal DNA from C. trachomatis to facilitate homologous recombination. (oregonstate.edu)
  • The final plasmid construct, pBVR2, was successfully transformed into C. trachomatis strain L2-434. (oregonstate.edu)
  • Garvin L, Vande Voorde R, Dickinson M, Carrell S, Hybiske K, Rockey D (2021) A broad-spectrum cloning vector that exists as both an integrated element and a free plasmid in Chlamydia trachomatis. (oregonstate.edu)
  • C. trachomatis is the most frequent cause of epididymitis in sexually active young men. (unboundmedicine.com)
  • The CDC recommends that sexually active women 25 and younger be screened once a year for chlamydia. (bartonhealth.org)
  • You may have this test if you are a sexually active woman 25 or younger or a man whose partner has been diagnosed with chlamydia. (bartonhealth.org)
  • Many people who have chlamydia do not experience any symptoms, which makes it important to get tested regularly if you are sexually active. (watchdoq.com)
  • 50-75% of the neonates born to infected mothers via vaginal delivery will acquire C. trachomatis . (unboundmedicine.com)
  • We have raised rabbit polyclonal antibodies against 5 of these proteins and we are currently analysing their subcellular localisation in C. trachomatis infected cells. (europa.eu)
  • Eight (30.77%) cases and 3 (6.38%) controls tested positive for C. trachomatis antibodies . (healthcaremagic.com)
  • In May 2019, Dr. Darville and her collaborators were awarded a five-year, $10.7 million grant from NIAID to establish the UNC Chlamydia Vaccine Initiative STI Cooperative Research Center . (unchealthcare.org)
  • 2019. https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617493/all/Chlamydia_Trachomatis_Infection. (unboundmedicine.com)