Methods used for the chemical synthesis of compounds. Included under this heading are laboratory methods used to synthesize a variety of chemicals and drugs.
Methodologies used for the isolation, identification, detection, and quantitation of chemical substances.
A technology, in which sets of reactions for solution or solid-phase synthesis, is used to create molecular libraries for analysis of compounds on a large scale.
Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.
The specialty of ANALYTIC CHEMISTRY applied to assays of physiologically important substances found in blood, urine, tissues, and other biological fluids for the purpose of aiding the physician in making a diagnosis or following therapy.
The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Laboratory tests demonstrating the presence of physiologically significant substances in the blood, urine, tissue, and body fluids with application to the diagnosis or therapy of disease.
A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
The branch of chemistry dealing with detection (qualitative) and determination (quantitative) of substances. (Grant & Hackh's Chemical Dictionary, 5th ed)
An examination of chemicals in the blood.
Hydrocarbons with at least one triple bond in the linear portion, of the general formula Cn-H2n-2.
Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.
The Nobel Prize is not a medical term, but a prestigious international award given annually in several categories, including Physiology or Medicine, for significant contributions to humanity that have conferred the greatest benefit to mankind.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Pollution prevention through the design of effective chemical products that have low or no toxicity and use of chemical processes that reduce or eliminate the use and generation of hazardous substances.
The conformation, properties, reaction processes, and the properties of the reactions of carbon compounds.
The study of CHEMICAL PHENOMENA and processes in terms of the underlying PHYSICAL PHENOMENA and processes.
Chemical and physical transformation of the biogenic elements from their nucleosynthesis in stars to their incorporation and subsequent modification in planetary bodies and terrestrial biochemistry. It includes the mechanism of incorporation of biogenic elements into complex molecules and molecular systems, leading up to the origin of life.
Characteristics or attributes of the outer boundaries of objects, including molecules.
Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

Urinary lithium: distribution shape, reference values, and evaluation of exposure by inductively coupled plasma argon-emission spectrometry. (1/698)

Inductively coupled plasma argon-emission spectrometry (ICPAES) was used to evaluate the lithium content of undiluted urine samples. The method can be performed with 1 mL of urine in a single tube using a routine ICPAES analysis for rapid and convenient assessment of lithium exposure in humans. Urine samples obtained from male workers (n = 86) who had not been exposed to lithium were used for the determination of this element by ICPAES. The obtained concentrations were corrected using a specific gravity of 1.024. The particular frequency distribution resulted in a log-normal distribution diagram for anatomical spread. Geometric mean value for urinary lithium in the nonexposed male workers was 23.5 microg/L, and the confidence interval from a log-normal distribution was 11.0 to 50.5 microg/L. Taking into consideration a short biological half-life and the massive urine excretion of lithium, urinary lithium was considered to be a useful index for monitoring of exposure. Calibration curves obtained for lithium standards had good sensitivity and linearity. Good reproducibility was assessed by lithium addition to urine samples. It was concluded that the obtained lithium reference values would be useful for the early diagnosis of lithium intoxication or in the assessment of the degree of exposure to lithium in subjects at risk.  (+info)

Cocaine metabolite kinetics in the newborn. (2/698)

The study goal was to determine the half-life elimination of cocaine and benzoylecgonine (BZE) in the newborn. Three 0.3-mL blood samples were collected during the first day of life. Urine was collected once daily. Cocaine and BZE concentrations were determined by gas chromatography-mass spectrometry. An extraction method was developed for measuring low concentrations of cocaine and BZE in small (0.1 mL) blood samples. Cocaine had a half-life of 11.6 h in one subject. The half-life of BZE during the first day of life, based on blood data in 13 subjects, was 16 h (95% confidence interval [CI], 12.8 to 21.4 h). The half-life of BZE during the first week of life, based on urine data in 16 subjects, was 11.2 h (95% CI, 10.1 to 11.8 h). The novel extraction method for small blood sample volumes should be applicable to other basic drugs.  (+info)

The urinary elimination profiles of diazepam and its metabolites, nordiazepam, temazepam, and oxazepam, in the equine after a 10-mg intramuscular dose. (3/698)

A method for the extraction of diazepam and its metabolites (nordiazepam, temazepam, and oxazepam) from equine urine and serum and their quantitation and confirmation by liquid chromatography-tandem mass spectrometry is presented. Valium, a formulation of diazepam, was administered at a dose of 10 mg intramuscularly to four standard-bred mares. Diazepam is extensively metabolized in the horse to nordiazepam, temazepam, and oxazepam. Diazepam urinary concentrations were found to be less than 6 ng/mL. Nordiazepam was found to be mainly in its glucuronide-conjugated form and was measured out to a collection time of 53-55 h. Oxazepam and temazepam were entirely conjugated, and their urinary concentrations were measured out to collection times of 121 h and 77-79 h, respectively. Diazepam and nordiazepam were measured in equine postadministration serum out to collection times of 6 and 54 h, respectively. Oxazepam and temazepam were not detected in postadministration serum.  (+info)

Solid-phase microextraction and GC-ECD of benzophenones for detection of benzodiazepines in urine. (4/698)

Benzodiazepines are common drugs that cause intoxication. Benzodiazepines and their metabolites can be converted by hydrolysis in acid to the corresponding benzophenones, which are easier to be separated from matrices because of their hydrophobic properties. In this study, a new separation technique called solid-phase microextraction (SPME), which can integrate extraction, concentration, sampling and sample introduction into one single procedure, has been employed to extract the products of benzodiazepines from urine after acid hydrolysis. The extracts were determined by gas chromatography with electron-capture detection (GC-ECD). The hydrolysis conditions were optimized by a statistic orthogonal design. Factors influencing direct-immersion (DI)-SPME process were also checked and chosen experimentally. The method was evaluated with spiked human urine samples. The recoveries of nine benzodiazepines ranged from 1 to 25%, with the highest for oxazolam and the lowest for bromazepam. The calibration curves were linear from 10 to 500 ng/mL for oxazolam, haloxazolam, flunitrazepam, nimetazepam, and clonazepam and from 20 to 1000 ng/mL for the others except bromazepam. The detection limits were 2-20 ng/mL for most drugs tested. The intraday and interday coefficients of variation of the developed method were within 10 and 17%, respectively. In addition, the utility of the method was confirmed by determining two ingested benzodiazepines (flunitrazepam and oxazolam) in a volunteer's urine; urine flunitrazepam was still detectable 32 h after a therapeutic dose (1.2 mg) of the drug. Finally, the DI-SPME was compared with the conventional liquid-liquid extraction with regard to detection limits and extraction efficiency of the analytes. By DI-SPME, more amounts of analytes could be introduced into GC column than by conventional liquid-liquid extraction, and thus lower detection limits of the analytes were reached, although benzophenone recoveries by DI-SPME were rather low.  (+info)

Comparison of solid-phase extraction and supercritical fluid extraction for the analysis of morphine in whole blood. (5/698)

A comparative study of the quantitative determination of morphine in whole blood using solid-phase extraction (SPE) and supercritical fluid extraction (SFE) is described. Comparative studies were made of the two techniques for the extraction of morphine from authentic forensic blood specimens. Quantitative results indicate that morphine levels measured using SPE correspond well to morphine levels produced using SFE. The two techniques are therefore comparable, although SFE is faster and cleaner and extracts may be produced with higher analyte recoveries than with SPE. This paper presents a comparison of the two techniques and the morphine concentrations determined in blood.  (+info)

Separation of long DNA molecules in a microfabricated entropic trap array. (6/698)

A nanofluidic channel device, consisting of many entropic traps, was designed and fabricated for the separation of long DNA molecules. The channel comprises narrow constrictions and wider regions that cause size-dependent trapping of DNA at the onset of a constriction. This process creates electrophoretic mobility differences, thus enabling efficient separation without the use of a gel matrix or pulsed electric fields. Samples of long DNA molecules (5000 to approximately 160,000 base pairs) were efficiently separated into bands in 15-millimeter-long channels. Multiple-channel devices operating in parallel were demonstrated. The efficiency, compactness, and ease of fabrication of the device suggest the possibility of more practical integrated DNA analysis systems.  (+info)

Application of blood cadmium determination to industry using a punched disc technique. (7/698)

A paper disc flameless atomic absorption spectroscopy (AAS) method is described for the determination of cadmium (Cd) in blood, enabling difficulties in sample preparation to be minimized. By control of the ashing step the matrix can be removed without loss of cadmium. Problems with the fast signal response during atomization can be met by spectral band width and temperature control. At the 106 pg level (471 nmol Cd/1 blood; 5-3 mug/100 ml) the relative standard deviation (RSD) was 0-06. Results in four industrial situations are reported. This description of the method should facilitate further investigation of its application to industry using capillary or venous blood.  (+info)

Cell sampling and analysis (SiCSA): metabolites measured at single cell resolution. (8/698)

By using a fine oil-filled glass microcapillary mounted on a micromanipulator, the solutes of individual plant cells can be sampled. These samples can then be analysed using a range of physical and chemical methods. Hydrostatic pressure (cell pressure probe), osmotic pressure (picolitre osmometer), organic solutes (enzyme-linked fluorescence microscope spectrometry or capillary electrophoresis), inorganic solutes (X-ray microdroplet analysis or capillary electrophoresis), (14)C (mass spectrometry), proteins (microdroplet immunoblotting), and mRNA (rt PCR) have been measured. Collectively, the battery of techniques is called single cell sampling and analysis (SiCSA) and all of the techniques have relevance to the study of plant metabolism at the resolution of the individual cell. This review summarizes the techniques for SiCSA and presents examples of applications used in this laboratory, in particular those relating to cell metabolism.  (+info)

Synthetic chemistry techniques refer to the methods and processes used in the laboratory to synthesize or create new chemical compounds or molecules. This can involve a wide range of procedures, including various types of reactions, separations, purifications, and characterizations. The goal of synthetic chemistry is often to produce a specific compound with desired properties, such as a drug molecule with therapeutic activity or a materials compound with unique physical or chemical characteristics. Synthetic chemists use their knowledge of organic, inorganic, physical, and analytical chemistry to design and execute efficient and effective syntheses, and they may employ automation, computational modeling, and other advanced tools to aid in their work.

Analytical chemistry techniques are a collection of methods and tools used to identify and quantify the chemical composition of matter. These techniques can be used to analyze the presence and amount of various chemicals in a sample, including ions, molecules, and atoms. Some common analytical chemistry techniques include:

1. Spectroscopy: This technique uses the interaction between electromagnetic radiation and matter to identify and quantify chemical species. There are many different types of spectroscopy, including UV-Vis, infrared (IR), fluorescence, and nuclear magnetic resonance (NMR) spectroscopy.
2. Chromatography: This technique separates the components of a mixture based on their physical or chemical properties, such as size, charge, or polarity. Common types of chromatography include gas chromatography (GC), liquid chromatography (LC), and thin-layer chromatography (TLC).
3. Mass spectrometry: This technique uses the mass-to-charge ratio of ions to identify and quantify chemical species. It can be used in combination with other techniques, such as GC or LC, to provide structural information about unknown compounds.
4. Electrochemical methods: These techniques use the movement of electrons to measure the concentration of chemical species. Examples include potentiometry, voltammetry, and amperometry.
5. Thermal analysis: This technique uses changes in the physical or chemical properties of a sample as it is heated or cooled to identify and quantify chemical species. Examples include differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA).

These are just a few examples of the many analytical chemistry techniques that are available. Each technique has its own strengths and limitations, and the choice of which to use will depend on the specific needs of the analysis.

Combinatorial chemistry techniques are a group of methods used in the field of chemistry to synthesize and optimize large libraries of chemical compounds in a rapid and efficient manner. These techniques involve the systematic combination of different building blocks, or reagents, in various arrangements to generate a diverse array of molecules. This approach allows chemists to quickly explore a wide chemical space and identify potential lead compounds for drug discovery, materials science, and other applications.

There are several common combinatorial chemistry techniques, including:

1. **Split-Pool Synthesis:** In this method, a large collection of starting materials is divided into smaller groups, and each group undergoes a series of chemical reactions with different reagents. The resulting products from each group are then pooled together and redistributed for additional rounds of reactions. This process creates a vast number of unique compounds through the iterative combination of building blocks.
2. **Parallel Synthesis:** In parallel synthesis, multiple reactions are carried out simultaneously in separate reaction vessels. Each vessel contains a distinct set of starting materials and reagents, allowing for the efficient generation of a series of related compounds. This method is particularly useful when exploring structure-activity relationships (SAR) or optimizing lead compounds.
3. **Encoded Libraries:** To facilitate the rapid identification of active compounds within large libraries, encoded library techniques incorporate unique tags or barcodes into each molecule. These tags allow for the simultaneous synthesis and screening of compounds, as the identity of an active compound can be determined by decoding its corresponding tag.
4. **DNA-Encoded Libraries (DELs):** DELs are a specific type of encoded library that uses DNA molecules to encode and track chemical compounds. In this approach, each unique compound is linked to a distinct DNA sequence, enabling the rapid identification of active compounds through DNA sequencing techniques.
5. **Solid-Phase Synthesis:** This technique involves the attachment of starting materials to a solid support, such as beads or resins, allowing for the stepwise addition of reagents and building blocks. The solid support facilitates easy separation, purification, and screening of compounds, making it an ideal method for combinatorial chemistry applications.

Combinatorial chemistry techniques have revolutionized drug discovery and development by enabling the rapid synthesis, screening, and optimization of large libraries of chemical compounds. These methods continue to play a crucial role in modern medicinal chemistry and materials science research.

Click chemistry is a term used to describe a group of chemical reactions that are fast, high-yielding, and highly selective. These reactions typically involve the formation of covalent bonds between two molecules in a simple and efficient manner, often through the use of a catalyst. The concept of click chemistry was first introduced by K. B. Sharpless, who won the Nobel Prize in Chemistry in 2001 for his work on chiral catalysis.

In the context of medical research and drug development, click chemistry has emerged as a valuable tool for rapidly synthesizing and optimizing small molecule compounds with therapeutic potential. By using click chemistry reactions to quickly and efficiently link different chemical building blocks together, researchers can rapidly generate large libraries of potential drug candidates and then screen them for biological activity. This approach has been used to discover new drugs for a variety of diseases, including cancer, infectious diseases, and neurological disorders.

One common type of click chemistry reaction is the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction, which involves the reaction between an azide and an alkyne to form a triazole ring. This reaction is highly selective and can be carried out under mild conditions, making it a popular choice for chemical synthesis in the life sciences. Other types of click chemistry reactions include the Diels-Alder cycloaddition, the thiol-ene reaction, and the Staudinger ligation.

Overall, click chemistry has had a significant impact on medical research and drug development by enabling the rapid and efficient synthesis of complex small molecule compounds with therapeutic potential. Its versatility and selectivity make it a powerful tool for researchers seeking to discover new drugs and better understand the molecular mechanisms underlying human disease.

Clinical chemistry is a branch of medical laboratory science that deals with the chemical analysis of biological specimens such as blood, urine, and tissue samples to provide information about the health status of a patient. It involves the use of various analytical techniques and instruments to measure different chemicals, enzymes, hormones, and other substances in the body. The results of these tests help healthcare professionals diagnose and monitor diseases, evaluate therapy effectiveness, and make informed decisions about patient care. Clinical chemists work closely with physicians, nurses, and other healthcare providers to ensure accurate and timely test results, which are crucial for proper medical diagnosis and treatment.

Organic chemistry is a branch of chemistry that deals with the study of carbon-containing compounds, their synthesis, reactions, properties, and structures. These compounds can include both naturally occurring substances (such as sugars, proteins, and nucleic acids) and synthetic materials (such as plastics, dyes, and pharmaceuticals). A key characteristic of organic molecules is the presence of covalent bonds between carbon atoms or between carbon and other elements like hydrogen, oxygen, nitrogen, sulfur, and halogens. The field of organic chemistry has played a crucial role in advancing our understanding of chemical processes and has led to numerous technological and medical innovations.

Clinical chemistry tests are a type of laboratory test that measure the levels of various chemicals or substances in the body. These tests can be used to help diagnose and monitor a wide range of medical conditions, including diabetes, liver disease, heart disease, and kidney disease. Some common clinical chemistry tests include:

1. Blood glucose test: Measures the level of glucose (sugar) in the blood. This test is commonly used to diagnose and monitor diabetes.
2. Electrolyte panel: Measures the levels of important electrolytes such as sodium, potassium, chloride, and bicarbonate in the blood. Imbalances in these electrolytes can indicate a variety of medical conditions.
3. Liver function tests (LFTs): Measure the levels of various enzymes and proteins produced by the liver. Abnormal results can indicate liver damage or disease.
4. Kidney function tests: Measure the levels of various substances such as creatinine and blood urea nitrogen (BUN) in the blood. Elevated levels of these substances can indicate kidney dysfunction or disease.
5. Lipid panel: Measures the levels of different types of cholesterol and triglycerides in the blood. Abnormal results can indicate an increased risk of heart disease.
6. Thyroid function tests: Measure the levels of hormones produced by the thyroid gland. Abnormal results can indicate thyroid dysfunction or disease.

Clinical chemistry tests are usually performed on a sample of blood, urine, or other bodily fluid. The results of these tests can provide important information to help doctors diagnose and manage medical conditions.

In the context of medicine, "chemistry" often refers to the field of study concerned with the properties, composition, and structure of elements and compounds, as well as their reactions with one another. It is a fundamental science that underlies much of modern medicine, including pharmacology (the study of drugs), toxicology (the study of poisons), and biochemistry (the study of the chemical processes that occur within living organisms).

In addition to its role as a basic science, chemistry is also used in medical testing and diagnosis. For example, clinical chemistry involves the analysis of bodily fluids such as blood and urine to detect and measure various substances, such as glucose, cholesterol, and electrolytes, that can provide important information about a person's health status.

Overall, chemistry plays a critical role in understanding the mechanisms of diseases, developing new treatments, and improving diagnostic tests and techniques.

Analytical chemistry is a branch of chemistry that focuses on the identification and quantification of chemical components within a sample. This field involves developing and using various analytical techniques and methods to determine the presence, concentration, structure, and purity of different chemicals or compounds in a mixture.

Some common analytical techniques include:

1. Spectroscopy: Using light or other electromagnetic radiation to study the interaction between matter and energy, providing information about the composition, structure, and properties of a sample. Examples include UV-Vis, IR, NMR, and mass spectrometry.
2. Chromatography: A separation technique that separates components in a mixture based on their interactions with a mobile phase (gas or liquid) and a stationary phase (solid or liquid). Common methods include gas chromatography (GC), liquid chromatography (LC), and thin-layer chromatography (TLC).
3. Electrochemical analysis: Measuring the electrical properties of a sample, such as potential, current, or resistance, to determine its composition or concentration. Examples include potentiometry, voltammetry, and conductometry.
4. Thermal analysis: Examining the physical and chemical changes that occur in a sample when it is heated or cooled, providing information about its composition, structure, and properties. Techniques include differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and dynamic mechanical analysis (DMA).
5. Spectrometry: Measuring the intensity of light dispersed by a sample as a function of wavelength or frequency to determine its composition, structure, or properties. Examples include atomic absorption spectroscopy (AAS), inductively coupled plasma mass spectrometry (ICP-MS), and X-ray fluorescence spectrometry (XRF).

Analytical chemists often work in various industries, such as pharmaceuticals, food, environmental testing, and forensics, to ensure product quality, safety, and compliance with regulations. They may also contribute to research and development efforts by developing new analytical methods or improving existing ones.

Blood chemical analysis, also known as clinical chemistry or chemistry panel, is a series of tests that measure the levels of various chemicals in the blood. These tests can help evaluate the function of organs such as the kidneys and liver, and can also detect conditions such as diabetes and heart disease.

The tests typically include:

* Glucose: to check for diabetes
* Electrolytes (such as sodium, potassium, chloride, and bicarbonate): to check the body's fluid and electrolyte balance
* Calcium: to check for problems with bones, nerves, or kidneys
* Creatinine: to check for kidney function
* Urea Nitrogen (BUN): to check for kidney function
* Albumin: to check for liver function and nutrition status
* ALT (Alanine Transaminase) and AST (Aspartate Transaminase): to check for liver function
* Alkaline Phosphatase: to check for liver or bone disease
* Total Bilirubin: to check for liver function and gallbladder function
* Cholesterol: to check for heart disease risk
* Triglycerides: to check for heart disease risk

These tests are usually ordered by a doctor as part of a routine check-up, or to help diagnose and monitor specific medical conditions. The results of the blood chemical analysis are compared to reference ranges provided by the laboratory performing the test, which take into account factors such as age, sex, and race.

Alkynes are a type of hydrocarbons that contain at least one carbon-carbon triple bond in their molecular structure. The general chemical formula for alkynes is CnH2n-2, where n represents the number of carbon atoms in the molecule.

The simplest and shortest alkyne is ethyne, also known as acetylene, which has two carbon atoms and four hydrogen atoms (C2H2). Ethyne is a gas at room temperature and pressure, and it is commonly used as a fuel in welding torches.

Alkynes are unsaturated hydrocarbons, meaning that they have the potential to undergo chemical reactions that add atoms or groups of atoms to the molecule. In particular, alkynes can be converted into alkenes (hydrocarbons with a carbon-carbon double bond) through a process called partial reduction, or they can be fully reduced to alkanes (hydrocarbons with only single bonds between carbon atoms) through a process called complete reduction.

Alkynes are important intermediates in the chemical industry and are used to produce a wide range of products, including plastics, resins, fibers, and pharmaceuticals. They can be synthesized from other hydrocarbons through various chemical reactions, such as dehydrogenation, oxidative coupling, or metathesis.

Pharmaceutical chemistry is a branch of chemistry that deals with the design, synthesis, and development of chemical entities used as medications. It involves the study of drugs' physical, chemical, and biological properties, as well as their interactions with living organisms. This field also encompasses understanding the absorption, distribution, metabolism, and excretion (ADME) of drugs in the body, which are critical factors in drug design and development. Pharmaceutical chemists often work closely with biologists, medical professionals, and engineers to develop new medications and improve existing ones.

I'm sorry for any confusion, but the term "Nobel Prize" is not a medical definition. The Nobel Prize is an international award given annually in several categories, and one of those categories is physiology or medicine. The Nobel Prize in Physiology or Medicine is awarded to individuals who have made significant discoveries of outstanding importance in the fields of life sciences and medicine. It is one of the most prestigious awards in these fields.

Molecular structure, in the context of biochemistry and molecular biology, refers to the arrangement and organization of atoms and chemical bonds within a molecule. It describes the three-dimensional layout of the constituent elements, including their spatial relationships, bond lengths, and angles. Understanding molecular structure is crucial for elucidating the functions and reactivities of biological macromolecules such as proteins, nucleic acids, lipids, and carbohydrates. Various experimental techniques, like X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and cryo-electron microscopy (cryo-EM), are employed to determine molecular structures at atomic resolution, providing valuable insights into their biological roles and potential therapeutic targets.

"Green Chemistry Technology," also known as "Sustainable Chemistry," refers to the design of chemical products and processes that reduce or eliminate the use and generation of hazardous substances. It aims to minimize negative impacts on human health and the environment, while maximizing economic benefits. This is achieved through the application of principles such as preventing waste, designing safer chemicals, using renewable feedstocks, and minimizing energy use. Green Chemistry Technology involves the development and implementation of novel chemical reactions, catalysts, and processes that are inherently safer and more environmentally benign than traditional methods.

I believe there may be some confusion in your question as "Organic chemistry phenomena" is a broad term and not a medical definition. However, I can provide you with an explanation of organic chemistry phenomena in a general context.

Organic chemistry is the study of carbon-containing compounds, their synthesis, reactions, properties, and structures. The term "organic" was originally used to describe biological materials, but now it refers to any compound that contains carbon atoms bonded to hydrogen atoms, except for some simple oxides, sulfides, and halides.

Organic chemistry phenomena encompass a wide range of processes and events related to organic compounds. These can include:

1. Structural properties: Understanding the arrangement of atoms in organic molecules and how they influence chemical behavior and reactivity.
2. Stereochemistry: The study of three-dimensional spatial arrangements of atoms in organic molecules, which can significantly impact their properties and biological activity.
3. Functional groups: Recognizing and understanding the behavior of specific groupings of atoms within organic molecules that determine their chemical reactivity.
4. Reaction mechanisms: Investigating and describing the step-by-step processes by which organic reactions occur, including the movement of electrons, formation and breaking of bonds, and energy changes.
5. Synthetic methodologies: Developing strategies and techniques for creating complex organic molecules from simpler precursors, often involving multiple steps and protecting group strategies.
6. Physical properties: Examining how factors such as molecular weight, polarity, solubility, and melting/boiling points affect the behavior of organic compounds in various conditions.
7. Spectroscopic analysis: Utilizing techniques like NMR (Nuclear Magnetic Resonance), IR (Infrared) spectroscopy, and mass spectrometry to analyze the structure and composition of organic molecules.
8. Biochemistry and medicinal chemistry: Exploring how organic compounds interact with biological systems, including drug design, development, and delivery.

While not a medical definition per se, understanding organic chemistry phenomena is crucial for many areas within medicine, such as pharmaceutical research, toxicology, and biochemistry.

Physical chemistry is a branch of chemistry that deals with the fundamental principles and laws governing the behavior of matter and energy at the molecular and atomic levels. It combines elements of physics, chemistry, mathematics, and engineering to study the properties, composition, structure, and transformation of matter. Key areas of focus in physical chemistry include thermodynamics, kinetics, quantum mechanics, statistical mechanics, electrochemistry, and spectroscopy.

In essence, physical chemists aim to understand how and why chemical reactions occur, what drives them, and how they can be controlled or predicted. This knowledge is crucial for developing new materials, medicines, energy technologies, and other applications that benefit society.

Chemical evolution is a term that refers to the set of processes thought to have given rise to life from simple inorganic compounds. It is a prebiotic process, meaning it occurred before the existence of life. The fundamental idea behind chemical evolution is that simple chemicals underwent a series of transformations, eventually leading to the formation of complex organic molecules necessary for life, such as amino acids, nucleotides, and lipids. These building blocks then came together to form the first self-replicating entities, which are considered the precursors to modern cells.

The concept of chemical evolution is based on several key observations and experiments. For example, it has been shown that simple inorganic compounds can be transformed into more complex organic molecules under conditions believed to have existed on early Earth, such as those found near hydrothermal vents or in the presence of ultraviolet radiation. Additionally, experiments using simulated prebiotic conditions have produced a variety of biologically relevant molecules, supporting the plausibility of chemical evolution.

It is important to note that chemical evolution does not necessarily imply that life emerged spontaneously or randomly; rather, it suggests that natural processes led to the formation of complex molecules that eventually gave rise to living organisms. The exact mechanisms and pathways by which this occurred are still subjects of ongoing research and debate in the scientific community.

Surface properties in the context of medical science refer to the characteristics and features of the outermost layer or surface of a biological material or structure, such as cells, tissues, organs, or medical devices. These properties can include physical attributes like roughness, smoothness, hydrophobicity or hydrophilicity, and electrical conductivity, as well as chemical properties like charge, reactivity, and composition.

In the field of biomaterials science, understanding surface properties is crucial for designing medical implants, devices, and drug delivery systems that can interact safely and effectively with biological tissues and fluids. Surface modifications, such as coatings or chemical treatments, can be used to alter surface properties and enhance biocompatibility, improve lubricity, reduce fouling, or promote specific cellular responses like adhesion, proliferation, or differentiation.

Similarly, in the field of cell biology, understanding surface properties is essential for studying cell-cell interactions, cell signaling, and cell behavior. Cells can sense and respond to changes in their environment, including variations in surface properties, which can influence cell shape, motility, and function. Therefore, characterizing and manipulating surface properties can provide valuable insights into the mechanisms of cellular processes and offer new strategies for developing therapies and treatments for various diseases.

Cyclization is a chemical process that involves forming a cyclic structure or ring-shaped molecule from a linear or open-chain compound. In the context of medicinal chemistry and drug design, cyclization reactions are often used to synthesize complex molecules, including drugs, by creating rings or fused ring systems within the molecule's structure.

Cyclization can occur through various mechanisms, such as intramolecular nucleophilic substitution, electrophilic addition, or radical reactions. The resulting cyclized compounds may exhibit different chemical and biological properties compared to their linear precursors, making them valuable targets for drug discovery and development.

In some cases, the cyclization process can lead to the formation of stereocenters within the molecule, which can impact its three-dimensional shape and how it interacts with biological targets. Therefore, controlling the stereochemistry during cyclization reactions is crucial in medicinal chemistry to optimize the desired biological activity.

Overall, cyclization plays a significant role in the design and synthesis of many pharmaceutical compounds, enabling the creation of complex structures that can interact specifically with biological targets for therapeutic purposes.

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Carbon paste electrodes with some chemistry techniques. In potentiometry Particle particular anode is portrayed as an electrode ... American Journal of Analytical Chemistry, 2018, 9, 591-601.. [92] R. Metelka, M. Žeravík, K. K. Vytřas, in Monitorování ... The authors are grateful to Department of Chemistry, College of Sciences, Tikrit University and Department of Chemistry, ... J. Wang, "Electroanalytical Chemistry," 2nd Edition. Wiley, New York, 2000. [3] M. N. Abbas, "Chemically Modified Carbon Paste ...
Analytical chemistry, All stub articles, Analytical chemistry stubs). ... Analytical technique is a method used to determine a chemical or physical property of a chemical substance, chemical element, ... The common spectrometer used in analytical chemistry is Mass spectrometry. In a mass spectrometer, a small amount of sample is ... Douglas A. Skoog; Stanley R. Crouch (2014). Fundamentals of analytical chemistry (Ninth ed.). Belmont, CA. ISBN 978-0-495-55828 ...
Details of the Analytical Chemistry facility at the Rowett Institute of Nutrition and Health ... Analytical Chemistry. The Analytical Chemistry Section was set up to carry out analysis for the Institute under strict regimes ... Analytical methods can be developed and validated and the facilities provided for them to be carried out. ...
... PRENESTI ... Analytical measurements of carboxylic acids, amino acids, inorganic anions and metals were executed to know the concentration ... Acid-base chemistry of red wine; Mixed solvent; Protonation constants; Speciation in real matrices; Chemical modelling and ... The jump from the analytical to the equilibrium composition may allow the prediction of the effect on red wines consequent to ...
Analytical Biochemical Techniques Analytical Chemistry Analytical Techniques Bioanalysis Bioanalytical Techniques Capillary ... experience in analytical chemistry with emphasis on trace element analysis and speciation analysis using coupled techniques ... Journal of Analytical & Bioanalytical Techniques peer review process verified at publons. Indexed In. * CAS Source Index (CASSI ... Jens J Sloth is a senior scientist in analytical chemistry at the National Food Institute of the Technical University in ...
Interest:Environmental Science, Material Science, Nuclear Analytical Technique. URL:https://chemistry.puchd.ac.in/show-biodata. ... Selected papers of ARCEBS 2023 will be published in Journal of Radioanalytical and Nuclear Chemistry ...
... and colloidal chemistry), and also is the Head of the Department of Analytical Chemistry and Food Science at the University of ... soil science and agricultural chemistry, biochemistry and molecular biology, nutrition and food science, biotechnology, food ... This 16 technique is carried out above the critical point of the extraction solvent, allowing for the control 17 and ... and colloidal chemistry), and also is the Head of the Department of Analytical Chemistry and Food Science at the University of ...
OCR AS and A Level Chemistry A (from 2015) qualification information including specification, exam materials, teaching ... Analytical techniques (IR and MS). Module 5: Physical chemistry and transition elements. *Reaction rates and equilibrium ( ... Synthesis and analytical techniques (02). 100. 2 hour 15 mins. 37%. Assesses content from modules 1, 2, 4 and 6. ... Analytical techniques (IR and MS). Practical activities are embedded throughout the course to encourage practical activities in ...
Microfluidic Analytical Techniques* * Milk, Human / chemistry* * N-Acetylneuraminic Acid / analysis * Oligosaccharides / ... Recent advances in analytical tools offer invaluable insights in understanding the specific functions and health benefits these ...
View all of the courses required to complete your major in Chemistry, including research and teaching assistant requirements. ... CHEM 220] Environmental, Analytical, and Geochemistry (1). Chemical equilibria are fundamental in the understanding of ... Laboratory: basic techniques and synthetic procedures and modern spectroscopic methods of structure determination; as part of ... Past offerings have included advanced organic chemistry, scientific glassblowing, medicinal chemistry, organometallic chemistry ...
The proposed techniques were validated and successfully applied to the analysis of drugs in pure and pharmaceutical forms. A ... The advantages and disadvantages of the proposed techniques were discussed in the context of the results and the sensitivity ... Furthermore, the greenness of the described methods was assessed using different tools, the analytical eco-scale, the green ... For the simultaneous quantitative analysis of aspirin and omeprazole, the TLC densitometry technique was applied using TLC ...
Stay updated with the latest research and news in environmental chemistry on our blog. Expert insights and analysis for a ... Q: How does analytical chemistry contribute to environmental monitoring?. Analytical techniques allow scientists to measure ... Analytical techniques play a vital role in environmental chemistry by allowing us to accurately measure pollutant ... Gas chromatography-mass spectrometry (GC/MS) is an essential analytical technique used in environmental chemistry to identify ...
All aspects of the field are represented, including analytical methodology, techniques, and instrumentation in both fundamental ... Current Analytical Chemistry strives to serve as an authoritative source of information in analytical chemistry and in related ... Current Analytical Chemistry publishes full-length/mini reviews and original research articles on the most recent advances in ... "Serious and independent sources of information such as Current Analytical Chemistry are desired and will expand the knowledge ...
Chapter 9. Thermal Techniques and Their Applications: Taking Advantage of the "Heat of the Moment". Alanna Silveira de Moraes, ... ISBN: N/A Categories: Analytical Chemistry, Analytical Chemistry and Microchemistry, Chemistry, Food Science and Technology, ... Series: Analytical Chemistry and Microchemistry, Food Science and Technology. BISAC: SCI013010. Analytical Chemistry: ... Home / Shop / Books / Science and Technology / Chemistry / Food Science and Technology / Analytical Chemistry: Developments, ...
2000-2010 analytical chemistry subject collection , 2010 analytical chemistry subject collection ... 2000-2010 analytical chemistry subject collection , 2010 analytical chemistry subject collection ... Y. Li, L. Wang, L. Zhang, and C. Chen, in Nuclear Analytical Techniques for Metallomics and Metalloproteomics, ed. C. Chen, Z. ... The integrated techniques provide a useful platform for the quantification, biodistribution and structural analysis of metallic ...
Voltammetric techniques. Handbook of instrumental techniques for analytical chemistry, pp.709-726. Scholz, Fritz (December 2015 ... Early voltammetric techniques had many problems, limiting their viability for everyday use in analytical chemistry. In ... 1996). Laboratory techniques in electroanalytical chemistry (2nd ed.). New York: Marcel Dekker. ISBN 0-8247-9445-1. OCLC ... "Voltammetric Techniques". Tufts University Department of Chemistry Barek, J. (2003). "Eighty Years of Polarography - History ...
Analytical Chemistry, Vol. 38, Issue 6. * DOI: 10.1021/ac60238a015 Thermodynamics and Stability of Rhabdophanes, Hydrated Rare ... Solution Technique for the Analysis of Silicates. journal, May 1966 * Suhr, N. H.; Ingamells, C. O. ... Chemistry and thermodynamics of europium and some of its simpler inorganic compounds and aqueous species journal, December 1985 ... The demonstrated process lowers the analytical cost from $70 to 80 dollars per sample to $10-15 per sample while significantly ...
CHEM 205 Equilibrium and Analytical Chemistry An introduction to the modern quantitative techniques of analysis in chemical ... CHEM 273 Chemistry and Society A pragmatic approach to chemistry for non-science majors. Basic problem solving (e.g. ... CHEM 321 Physical Chemistry I An introduction to thermodynamics and quantum chemistry. The macroscopic behavior of matter as ... CHEM 100A GENERAL CHEMISTRY I An introduction to the fundamental concepts of chemistry, including atomic and molecular ...
Knowledge of these techniques, the advantage and limitation of them, and the actual workflow for sample preparation, analysis ... Introduces a range of chromatography and spectroscopic techniques for the analysis of inorganic and organic compounds and ... 1. Introduction to analytical chemistry;. 2. Modern instrumental analysis techniques;. 3. Sampling procedures and sample ... Knowledge of these techniques, the advantage and limitation of them, and the actual workflow for sample preparation, analysis ...
Blum, C. and Subramaniam, V. Single-molecule spectroscopy of fluorescent proteins.Analytical and Bioanalytical Chemistry 393: ... Willis, R. C. Portraits of life, one molecule at a time. Analytical Chemistry 79: 1785-1788 (2007). ... Analytical Chemistry 74: 3511-3517 (2002).. *Heilemann, M., Margeat, E., Kasper, R., Sauer, M. and Tinnefeld, P. Carbocyanine ... Moerner, W. E. A dozen years of single-molecule spectroscopy in physics, chemistry, and biophysics. Journal of Physical ...
Analytical Chemistry, 2019, 91, 13794-13802. DOI 10.1021/acs.analchem.9b03259 Lobo, D.P.; Wemyss, A.M.; Smith, D.J; Straube, A ... Developing new polarised spectroscopy techniques for biomacromolecules. Particular expertise in circular and linear dichroism, ... Alison moved to Macquarie University in 2017 and is an Emeritus Professor in the Department of Chemistry at Warwick. ... B. Nordén, A. Rodger, T. Dafforn, Royal Society of Chemistry, 2010, pp293. DOI: 10.1039/9781847559524 ...
2005). Passive sampling techniques for monitoring pollutants in water. TrAC, Trends in Analytical Chemistry, 24(10), 845-868. ... An example of the analytical workflow is given in Figs. S3 and S4. The detection of at least one product ion for each precursor ... The analytical workflow was able to identify 219 compounds with confidence in the Hennops and Jukskei Rivers. A total of 83 ... Analytical and Bioanalytical Chemistry, 387(4), 1153-1157. https://doi.org/10.1007/s00216-006-0773-y. ...
Covers all aspects of the theory and practice of analytical science, both fundamental and applied, including bioanalysis ( ... imaging techniques, sampling and sample handling, chemometrics/statistics, atomic and molecular spectroscopy and all other ... International journal concerned with the development and application of analytical and bioanalytical techniques. ... Royal Society of Chemistry (Great Britain), Society of Public Analysts (Great Britain), Society for Analytical Chemistry, ...
Analytical chemistry is an essential skill for every chemist.. In this module, you will have the opportunity to design your own ... You will gain an understanding of the principles behind these techniques.. You will also gain valuable insight into analytical ... chemistry project designing and planning.. Teaching. .chart { width: 200px; height: 200px; } 10%: Lecture. 90%: Practical ( ... The aim of this module is to train you with experiences of using modern analytical instruments to analyse the chemical ...
C. L. Bentley et al., "Nanoscale electrochemical mapping", ACS Analytical Chemistry, 2018, 91 (1), 84-108.. In summary, this ... The "scanning probe" techniques have been used to investigate a range of phenomena in corrosion complemented with quantum ... submitted to ACS Analytical Chemistry.. Over the project period, one review article was published addressing various aspects of ... These allowed the use of "scanning probe" techniques to reveal activities of single grains on polycrystalline iron and zinc. ...

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