Aging Cell

Stem cell theory of aging

Timeline of aging research

Biomarkers of aging

SDD-AGE

Ending Aging

Primary age-related tauopathy

Free-radical theory of aging

Neuroscience of aging

Disposable soma theory of aging

Genetics of aging

Age-1

Aging brain

Aging in dogs

Wales in the Middle Ages

Aging-associated diseases

Lifespan: Why We Age - and Why We Don't Have To

Hallmarks of aging

Buck Institute for Research on Aging

Network theory of aging

Aging and society

The New Golden Age

No-Aging Diet

Little Ice Age volcanism

International Aging Research Portfolio

Mitochondrial DNA

Centenarian

GSTO1

TP53BP1

Mitomycin C

Senescent51

• A team led by Professor Lorna Harries, Professor of Molecular Genetics at the University of Exeter, has discovered a new way to rejuvenate inactive senescent cells. (sciencedaily.com)
• The University of Exeter research team, working with Professor Richard Faragher and Dr Elizabeth Ostler from the University of Brighton, found that splicing factors can be switched back on with chemicals, making senescent cells not only look physically younger, but start to behave more like young cells and start dividing. (sciencedaily.com)
• As we age, our tissues accumulate senescent cells which are alive but do not grow or function as they should. (sciencedaily.com)
• Senescent cells, which can be found in most organs from older people, also have fewer splicing factors. (sciencedaily.com)
• Using this new "cocktail" of six factors, the senescent cells, programmed into functional iPSC cells, re-acquired the characteristics of embryonic pluripotent stem cells. (eurekalert.org)
• Passaging 40.0 times resulted in senescent fibroblasts with no growth over 14 days, morphological alterations typical of aged cells, and a rise in cell-cycle regulator p21 (CDKN1A) transcripts. (news-medical.net)
• Researchers have uncovered three new agents to add to the emerging repertoire of drugs that aim to delay the onset of aging by targeting senescent cells - cells that contribute to frailty and other age-related conditions. (sciencedaily.com)
• A recent study of human cell cultures shows that the drugs, fisetin and two BCL-XL inhibitors -- A1331852 and A1155463 -- cleared senescent cells in vitro. (sciencedaily.com)
• Senescent cells accumulate with age and at sites of multiple chronic conditions, such as in fat tissue in diabetes, the lungs in chronic pulmonary diseases, the aorta in vascular disease, or the joints in osteoarthritis," says James Kirkland, M.D., Ph.D., director of the Robert and Arlene Kogod Center on Aging. (sciencedaily.com)
• At Mayo Clinic, we discovered the first senolytic drugs -- agents that selectively eliminate senescent cells while leaving normal cells unaffected. (sciencedaily.com)
• Then, using an ATPLite and a crystal violet assay, researchers measured cell viability and demonstrated that fisetin and BCL-XL inhibitors A1331852 and A1155463 cleared senescent cells in vitro. (sciencedaily.com)
• We predict many more senolytic drugs will appear at an accelerating pace over the next few years and that these drugs will be improved to more effectively target senescent cells," says Dr. Kirkland. (sciencedaily.com)
• Dec. 28, 2022 Researchers are bridging mouse and human data to reveal the biology of senescent cells. (sciencedaily.com)
• June 30, 2022 Senescent cells -- those that have lost the ability to divide -- accumulate with age and are key drivers of age-related diseases, such as cancer, dementia and cardiovascular disease. (sciencedaily.com)
• For this purpose, a cellular model of senescent myocardial cells was set up and evaluated using colorimetric, fluorimetric, and immunometric techniques. (hindawi.com)
• Identifying the mechanisms that contribute to excessive unchecked cell growth (neoplasia), and the contribution of damaged non-growing (senescent) cells to human diseases, including arthritis, cardiovascular disease and muscle wasting. (mayo.edu)
• One type of aged cells, senescent cells, are highly abundant at disease sites, indicating that they are particularly important drivers of pathology. (mayo.edu)
• Senescent cells are of particular interest to investigators in the Center for Biomedical Discovery's cancer and cell aging platform. (mayo.edu)
• Each time our cells reproduce, our telomeres get a tiny bit shorter and when they get too short, cells will die or become senescent (stop functioning properly). (elephantjournal.com)
• We are covering it again in light of a new research article published in Science , as both this episode and this newer research article are trying to find a way to kill senescent cells. (a16z.com)
• The article we discuss in this episode, " Senolytic CAR T cells reverse senescence-associated pathologies " by Amor et al, published in Nature , selectively targets senescent cells with engineered T cells. (a16z.com)
• The new article, " Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders " by Johmura et al, published in Science , kills senescent cells by inhibiting an enzyme essential for their metabolism. (a16z.com)
• So what are senescent cells, and why is killing them so important? (a16z.com)
• Senescent cells are those in a non-dividing but metabolically active state, and what's interesting is that they play both protective and pathological roles in the body. (a16z.com)
• When senescent cells accumulate, as often happens during aging, they kick off an inflammatory process that underlies many age-related diseases. (a16z.com)
• Thus the targeted destruction of senescent cells has the potential to treat a wide range of conditions, and possibly to improve longevity. (a16z.com)
• That's is the conclusion of first-of-a-kind study by researchers at the Mayo Clinic, which found that mice lived about 25 percent longer on average if so-called "senescent" cells were cleared out from their bodies. (technologyreview.com)
• Nathaniel David, CEO of the startup, says the company has identified drugs that can kill senescent cells in lab animals. (technologyreview.com)
• This study isn't the first to make mice live longer, although it does appear to be the first time the effect was achieved by targeting senescent cells. (technologyreview.com)
• Cells become senescent when they stop dividing. (technologyreview.com)
• What wasn't known until today's result was whether eliminating senescent cells would also delay aging in normal mice. (technologyreview.com)
• Although the genetic method would be hard to use in people, drugs could be developed to kill senescent cells. (technologyreview.com)
• Unity, which is being funded by the venture firms Arch Venture Partners and Venrock, as well as the Mayo Clinic and the Chinese drug company Wuxi, says it is exploring whether deleting senescent cells can treat specific conditions like glaucoma, although "the big dream is a drug that extends health span," says David. (technologyreview.com)
• He says it's possible to imagine a person taking a drug to clear out inactive cells once every few years, starting in early middle age when senescent cells begin to accumulate. (technologyreview.com)
• Because removing senescent cells could treat a range of ailments, Unity will attempt to raise and spend large sums of money to advance drugs into studies, says Robert Nelsen, the managing director of Arch, who has played a leading role in some recent high-profile startups including Juno Therapeutics as well as Grail, a $100 million effort to develop cancer blood tests announced this year. (technologyreview.com)
• The senolytic drug combination of dasatinib and quercetin cleared senescent cells from obese mice in a study by researchers at the Mayo Clinic in Rochester, Minnesota funded by NIA. (nih.gov)
• When the senescent cells were removed, cell growth resumed in the brain regions involved in that process, also known as neurogenesis, and obesity-related anxiety behavior decreased. (nih.gov)
• Over time, accumulation of senescent cells may slow or stop cell regeneration and tissue maintenance, thus contributing to tissue aging. (nih.gov)
• Clearing senescent cells from the brain and other tissues can delay, prevent, or alleviate multiple age-related disorders. (nih.gov)
• The researchers sought to determine whether anxiety-like behavior in obesity can be caused by increased senescent cell burden. (nih.gov)
• They used a mouse model of obesity to test whether the drug combination could clear senescent cells and thus reduce anxious behaviors associated with obesity. (nih.gov)
• When the senescent cells had been eliminated from the mice brains, anxious behavior decreased and new nerve cell growth in the brain was detected. (nih.gov)
• The scientists note that the data show that senescent cells play a role in causing impaired cell growth due to obesity. (nih.gov)
• They also conclude that this study provides proof of concept that senescent cells contribute to obesity-induced anxiety and that senolytics may offer a potential new way for treating neuropsychiatric disorders. (nih.gov)
• Aging is associated with exhaustion of stem cell pools that are responsible for renewal of the damaged, senescent and dying cells of different organs. (placidway.com)
• Treatment with fetal stem cell stimulate self-renewal of the organism of the patient due to enhanced functional substitution of senescent and dying cells and release of trophic factors that are involved in regeneration of the tissues. (placidway.com)
• Aged, or senescent, cells are thought to represent a driver of the ageing process and other groups have shown that if such cells are removed in animal models, many features of ageing can be corrected. (neurosciencenews.com)
• This new work from the Exeter team found that stopping the activity of the pathways ERK and AKT, which communicate signals from outside the cell to the genes, reduced the number of senescent cells in in cultures grown in the laboratory. (neurosciencenews.com)
• This, in turn, could lead to a build-up of senescent cells - those which have deteriorated or stopped dividing as they age. (neurosciencenews.com)
• They also noted a reduction in the number of senescent cells. (neurosciencenews.com)
• Researchers saw a reversal of many of the features of senescent cells that have been linked to the ageing process, leading to a rejuvenation of cells. (neurosciencenews.com)

Progenitor cells7

• In one study, the authors focus on the effects of aging on adult neurogenesis, a process of producing new neurons from neural stem cells and neural progenitor cells in the neocortex, comparing the dentate gyrus and subventricular zone. (novapublishers.com)
• There is good evidence that similar fibroblasts, or progenitor cells, reside in most organs in the body and so they may undergo similar age-related degeneration to what Wisoo has uncovered in the hair follicle," says Biernaskie. (ucalgary.ca)
• Identifying new cell types, in particular new progenitor cells, that are injured in COPD could really accelerate the development of new treatments," said study first author Maria Basil, MD, Ph.D., an instructor of Pulmonary Medicine. (worldhealth.net)
• In this study, we observed that the expression of pseudouridine (Ψ) synthase 10 is increased in aged hematopoietic stem and progenitor cells (HSPC) and enforced protein of Ψ synthase 10 (PUS10) recapitulates the phenotype of aged HSC, which is not achieved by its Ψ synthase activity. (haematologica.org)
• They develop from progenitor cells-descendants of adult stem cells that differentiate into specialized cell types. (scitechdaily.com)
• This enhancement enables the meticulous labeling and tracking of the dynamics of rare progenitor cells in mammalian organs. (scitechdaily.com)
• For the current study, the researchers analyzed more than 10,000 newborn progenitor cells from across entire mouse brains spanning three ages (young, mature, and elderly) with a synthetic molecule known as 5-ethynyl-2-deoxyuridine (EdU). (scitechdaily.com)

Embryonic13

• These old cells were reprogrammed in vitro to induced pluripotent stem cells (iPSC) and to rejuvenated and human embryonic stem cells (hESC): cells of all types can again be differentiated after this genuine "rejuvenation" therapy. (eurekalert.org)
• Human embryonic stem cells (hESC) are undifferentiated multiple-function cells. (eurekalert.org)
• Since 2007, a handful of research teams across the world have been capable of reprogramming human adult cells into induced pluripotent cells (iPSC), which have similar characteristics and potential to human embryonic stem cells (hESC). (eurekalert.org)
• This kind of reprogramming makes it possible to reform all human cell types without the ethical restrictions related to using embryonic stem cells. (eurekalert.org)
• The rejuvenated iPSC cells were again differentiated to adult cells and compared to the original old cells, as well as to those obtained using human embryonic pluripotetent stem cells (hESC). (eurekalert.org)
• The Yamanaka factors that can reprogram cells into their embryonic-like state are at the heart of longevity research. (scientificamerican.com)
• The discovery of the ' Yamanaka factors '-four transcription factors (Oct3/4, Sox2, c-Myc and Klf4), ), proteins that can reprogram a fully mature cell into an embryonic-like state-earned Kyoto University researcher Shinya Yamanaka a share of the Nobel prize in 2012. (scientificamerican.com)
• The finding, described in 2006, transformed stem cell research by providing a new source of cells that resemble embryonic stem cells, which are able to give rise to any type of specialized cell in the body except sex cells. (scientificamerican.com)
• Researchers in America have discovered that vaccinating mice with embryonic stem cells prevented lung cancer in those animals that had had cancer cells transplanted into them after the vaccination or that had been exposed to cancer-causing chemicals. (fightaging.org)
• Whether the metabolic and dividing activity of hematopoietic stem cells during embryonic development or in adolescence already predetermines later aging of the cells had not been previously been reported and was therefore the subject of the current study. (idw-online.de)
• It is important to emphasize, that in contrast to "Embryonic stem cells" that are derived from the inner cell mass of the blastocyst that are known to be tumorigenic, fetal stem cells derived from the fetal tissues during the period of 8-20 weeks of development did not show same tendency in in-vivo experiments. (placidway.com)
• However, their real aim was to create so-called human embryonic stem cells to replace worn-out body parts. (zmescience.com)
• They were surprised to find that the cells didn't turn into embryonic stem cells as in the previous study by Yamaka. (zmescience.com)

20231

• There is this phenomenon of premature aging of the immune system," said Cornelia Weyand, PhD, director of the Center for Translational Medicine at Stanford University, Stanford, California, at the German Rheumatology Congress 2023 in Leipzig, Germany. (medscape.com)

Researchers30

• The researchers applied compounds called resveratrol analogues, chemicals based on a substance naturally found in red wine, dark chocolate, red grapes and blueberries, to cells in culture. (sciencedaily.com)
• The researchers have successfully rejuvenated cells from elderly donors, some over 100 years old, thus demonstrating the reversibility of the cellular aging process. (eurekalert.org)
• The researchers proved that the iPSC cells thus obtained then had the capacity to reform all types of human cells. (eurekalert.org)
• Researchers first multiplied skin cells (fibroblasts) from a 74 year-old donor to obtain the senescence characterized by the end of cellular proliferation. (eurekalert.org)
• To check the "rejuvenated" characteristics of these cells, the researchers tested the reverse process. (eurekalert.org)
• Researchers identified a specific DNA mutation in cancer cells from both blood samples, in which two genes called BCR and ABL1 fuse together. (worldhealth.net)
• In a recent study published in the Aging Journal, researchers identified chemical drug combinations that could reverse cellular aging. (news-medical.net)
• In the present study, researchers devised high-throughput cellular assays that can differentiate between young, older, and aged cells of the body, including transcriptomic aging clocks and real-time quantitative nucleocytoplasmic compartmentalization (NCC) assays, to identify compounds that can reverse the aging process without genomic alterations. (news-medical.net)
• The researchers discovered that OSK expression in cells, such as murine and human fibroblasts, may significantly repair the epigenetic environment and patterns of gene expression of aged cells. (news-medical.net)
• Thanks to a promising new way of measuring DNA's age, researchers from University of California Los Angeles have developed a biological clock that may, for the first time, estimate the chronological age of cells with relative accuracy. (time.com)
• Mayo Clinic researchers, working in collaboration with the University Medical Center Groningen and The Scripps Research Institute, induced senescence in human cell cultures by radiating human primary preadipocytes, Human Umbilical Vein Endothelial Cell cultures and IMR90 cell cultures. (sciencedaily.com)
• Researchers were able to regenerate heart cells in mice by temporarily boosting levels of the protein ERBB2. (worldhealth.net)
• For decades, researchers studying aging and hair loss have focused on keratinocytes, the cells that make up the bulk of the hair follicle and eventually give rise to the hair fibre. (ucalgary.ca)
• Researchers at the Scripps Translational Science Institute (STSI) and The Scripps Research Institute (TSRI) who looked at the effect of aging on induced pluripotent stem cells (iPSCs) found that genetic mutations increased with the age of the donor who provided the source cells, according to study results published today by the journal Nature Biotechnology. (scripps.org)
• Researchers study the mechanisms that control and regulate cell growth, or that fail to do so in cancer. (mayo.edu)
• Researchers at the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) have now found a gene mechanism that is responsible for the aging of hematopoietic stem cells. (idw-online.de)
• Researchers at the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) in Jena have been able to demonstrate that in mice, the growth factor Igf2bp2 controls hematopoietic stem cell function in young adulthood by activating stem cell metabolism and growth. (idw-online.de)
• A new type of cell that resides deep within human lungs and may play a key role in human lung diseases has been discovered by researchers at the Perelman School of Medicine at the University of Pennsylvania. (worldhealth.net)
• The researchers, who report their findings today in Nature , analyzed human lung tissue to identify the new cells, which they call respiratory airway secretory cells (RASCs). (worldhealth.net)
• AT2 cells are known to become abnormal in COPD and other lung diseases, and the researchers found evidence that defects in RASCs might be an upstream cause of those abnormalities. (worldhealth.net)
• Rockefeller University researchers have developed TrackerSci, a groundbreaking method for tracking the development and aging of brain cells, which could revolutionize the understanding of neurological diseases and aging. (scitechdaily.com)
• Researchers at Rockefeller University are taking the same approach with newborn brain cells-but these neonates will keep their ID tags for life, so that scientists can track how they grow and mature, as a means for better understanding the brain's aging process. (scitechdaily.com)
• This innovative technique allowed the researchers to analyze tens of thousands of gene expressions and the chromatin landscapes of these newborn cells as they grew into families of cell types with different molecular functions. (scitechdaily.com)
• Summary: Researchers report certain genes and pathways that regulate slicing factors play a critical role in the aging process. (neurosciencenews.com)
• Disrupting these genetic processes, researchers say, could reverse signs of aging in human cells. (neurosciencenews.com)
• UK researchers have rejuvenated the skin cells of a 53-year-old woman so they are the equivalent of a 23-year-olds. (zmescience.com)
• The technique used by Reik and his team comes from the 1990s when researchers from the Roslin Institute found a way to turn an adult mammary gland cell taken from a sheep into an embryo. (zmescience.com)
• Lund University researchers find that individual blood stem cells (depicted as snowflakes in this image) express stress-related transcripts when subjected to experimental procedures involving cell incubation at elevated temperatures. (lu.se)
• According to a recent study by researchers from the Lund Stem Cell Center at Lund University, published in Nature Aging, the genetic changes previously observed in aging blood stem cells could be linked to cell extraction stress rather than the aging process itself. (lu.se)
• Researchers at Lund Stem Cell Center are particularly interested in studying hematopoietic stem cells, their changes with age, and the factors contributing to this decline. (lu.se)

Genes17

• This discovery, funded by the Dunhill Medical Trust, builds on earlier findings from the Exeter group that showed that a class of genes called splicing factors are progressively switched off as we age. (sciencedaily.com)
• Our data suggests that using chemicals to switch back on the major class of genes that are switched off as we age might provide a means to restore function to old cells. (sciencedaily.com)
• These old cells lose the ability to correctly regulate the output of their genes. (sciencedaily.com)
• When activated, genes make a message that gives the instructions for the cell to behave in a certain way. (sciencedaily.com)
• Most genes can make more than one message, which determines how the cell acts. (sciencedaily.com)
• This is the latest in a recent surge of investment in ventures seeking to build anti-aging interventions on the back of basic research into epigenetic reprogramming (modifying chemical marks on DNA to turn genes on or off). (scientificamerican.com)
• influences which genes are activated and which tend to change as cells age. (scientificamerican.com)
• In the concluding review the authors evaluated the effects of natural and chemical compounds on promoter activities of several human DNA repair-associated genes in HeLa S3 cells. (novapublishers.com)
• Sustaining an appropriate level of genes encoding DNA repair factors is thought to be necessary for cell survival by preventing the accumulation of DNA mismatches and epigenetic alterations. (novapublishers.com)
• Gene set enrichment analysis (GSEA) was performed to identify pathways related to the differences and similarities between chemical therapies, aging signatures, and the OSK(M)-induced iPSCs using the Kyoto Encyclopedia of Genes and Genomes (KEGG), Reactome pathways, and HALLMARK genomic databases. (news-medical.net)
• Shin compared fibroblasts from different aged animals - young, middle-aged and older - to understand which particular genes are changing with advanced age and how they might contribute to the cell dysfunction. (ucalgary.ca)
• Genetic and epigenetic causes of cancer and aging (for example, how do genes and the environment cause specific types of cancer or cell and tissue aging? (mayo.edu)
• Initial studies on worms have shown that the absence of certain growth genes slows down their development but can also delay their aging. (idw-online.de)
• The research group specializes in the study of genes at the single-cell level. (idw-online.de)
• Eventually, we may be able to identify genes that rejuvenate without reprogramming, and specifically target those to reduce the effects of aging. (zmescience.com)
• The fact that we also saw a reverse of aging indicators in genes associated with diseases is particularly promising for the future of this work," Diljeet Gill, co-author, said in a statement. (zmescience.com)
• Suspecting that experimental procedures used during gene expression analysis might be influencing the results, they examined how stress-related genes behaved in cells collected under different conditions. (lu.se)

Fibroblasts8

• The NCC reporter system was introduced into human fibroblasts from a 22-year-old donor, and experiments were conducted to monitor age-associated alterations in nuclear permeability. (news-medical.net)
• The fibroblasts were treated with doxycycline to activate the OSK system, and the NCC assay underwent testing to determine whether the system could identify the impact of genomically-regulated epigenetic age reversing. (news-medical.net)
• But a study from the University of Calgary Faculty of Veterinary Medicine (UCVM) has found that it's actually a small population of specialized cells within the hair follicle called fibroblasts, and the dermal stem cells that maintain them, that may cause hair loss. (ucalgary.ca)
• A loss of dermal stem cells prevents production of new fibroblasts and so the population can't be maintained. (ucalgary.ca)
• The aged fibroblasts effectively lose their regenerative ability. (ucalgary.ca)
• Our work shows that there are specific genetic programs that allow them to continually self-renew and produce new fibroblasts that serve different functions - so maintaining those genetic programs into old age will certainly improve skin health and perhaps enhance their ability to effectively heal wounds," says Biernaskie. (ucalgary.ca)
• Generate a bank of fibroblasts and corresponding induced pluripotent stem cells (iPSCs) that represent the breadth of healthy adult chronological age from a human cohort extensively phenotyped for key physical and functional measures of biological age. (salk.edu)
• To address this question we procured a panel of primary dermal fibroblasts from donors aged 2-92 years old, and tracked the movement of cells seeded on collagen-coated substrates for ten hours, taking images every 3 minutes. (aiche.org)

Adult13

• They can divide and form all types of differentiated adult cells in the body (neurones, cardiac cells, skin cells, liver cells, etc. (eurekalert.org)
• This research paves the way for the therapeutic use of iPS, insofar as an ideal source of adult cells is provided, which are tolerated by the immune system and can repair organs or tissues in elderly patients. (eurekalert.org)
• After injury, adult skeletal muscle regenerates by activating muscle stem cells that fuse with the existing muscle cells to repair the damage. (ca.gov)
• This research illustrates the potential for recruiting adult resident stem cells in tissue repair. (ca.gov)
• Adult (or tissue-specific) stem cells reside in many different organs and play important roles in maintaining the integrity of those tissues," says Shin, the lead author of the paper and an Alberta Innovates MD PhD scholar. (ucalgary.ca)
• Each adult stem cell population acts a little bit differently in the body and, as a result, how they change due to aging is also different. (ucalgary.ca)
• The Baltimore company has developed a solution of stem cells taken from a single adult donor. (fightaging.org)
• At present the research community is progressing towards this goal one stem cell population at a time, but it seems plausible that some discoveries will be broadly applicable to all stem cells in the adult body. (fightaging.org)
• New cells are continuously produced in the adult mammalian brain, a critical process associated with memory, learning, and stress. (scitechdaily.com)
• Quantifying the abundance of cells classified per cluster for all ages, we found that there was an increased propensity of various cluster for young and elderly donors, however, for post-adolescent/adult donors there was a similar likelihood of either cluster. (aiche.org)
• His new method, known as induced pluripotent stem cells (IPS) , added chemicals to adult cells for about 50 days. (zmescience.com)
• This caused genetic changes that turned the adult cells into stem cells. (zmescience.com)
• We also have a strong interest in basic stem cell biology with a clear focus on neural stem cells and neurogenesis in the adult and aging brain. (lu.se)

Epigenetic4

• Several groups, including those headed by Stanford University's Vittorio Sebastiano, the Salk Institute's Juan Carlos Izpisúa Belmonte and Harvard Medical School's David Sinclair (See Table), have shown that partial reprogramming can dramatically reverse age-related characteristics in the eye, muscle and other tissues in cultured mammalian cells and even rodent models by countering epigenetic changes associated with aging. (scientificamerican.com)
• Loss of epigenetic information is a characteristic of cellular aging in eukaryotes, resulting in changes in gene expression, loss of cellular identity, mitochondrial malfunction, inflammation, and cellular senescence, which contribute to aging and age-related illnesses. (news-medical.net)
• The method could detect the consequences of a genetically induced epigenetic reversal of age using lentivirus transduction and gene ontology (GO) analysis. (news-medical.net)
• Unlike iPSC-based reprogramming processes that can erase epigenetic and transcriptional signatures of aging, direct-conversion approaches can better maintain molecular signatures of aging in resultant cell types. (salk.edu)

Tissue11

• The authors of the present study previously demonstrated that ectopically induced transcription factors, Octamer-binding transcription factor 4 (OCT-4), sex-determining region Y-box 2 (SOX2), and Kruppel-like factor 4 ( KLF-4) (collectively known as OSK factors) among mammals can reverse aging by restoring youthful patterns of deoxyribonucleic acid (DNA) methylation, transcriptomic profiles, and tissue functioning without cell identity loss. (news-medical.net)
• They compared methylation in healthy and cancerous human tissue in 8,000 samples of 51 types of tissues and cells, including those in the heart, lungs, brain, liver, and kidney. (time.com)
• Using that data to build a statistical model of a biological clock that correlated methylation with chronological age, the scientists found that breast tissue ages faster than the rest of a woman's body. (time.com)
• This is a really important study in highlighting how aging impacts tissue-resident stem cells and the molecular changes behind this degenerative process. (ucalgary.ca)
• Vangsness and his colleagues injected the stem cell solution into the knees of 55 patients with a torn meniscus, cartilage-like tissue in the knee. (fightaging.org)
• It offers a comprehensive resource of tissue-specific and sex-specific aging dysregulations and highlights age-related intercellular communication changes widespread across the whole body, such as the upregulation of immune system processes and inflammation, the downregulation of developmental processes, angiogenesis and extracellular matrix organization and the deregulation of lipid metabolism. (nature.com)
• In lung tissue from people with COPD, as well as from people without COPD who have a history of smoking, they observed many AT2 cells that were altered in a way that hinted at a faulty RASC-to-AT2 transformation. (worldhealth.net)
• Drive technology development to create novel organoid and hybrid-cell models to investigate the role of cellular heterogeneity in human tissue and organ aging. (salk.edu)
• These are cells that don't die, but sit there and excrete all kind of molecules that degrade tissue," he says. (technologyreview.com)
• Wilson Jones concluded that multinucleate cell angiohistiocytoma is a chronic inflammatory disorder of unknown cause manifested by vascular hyperplasia and connective-tissue cells that have lost their function after prolonged stimulation. (medscape.com)
• Therefore, in addition to epidermal Langerhans cells, other potential cellular origins for LCH include dermal langerin + dendritic cells, lymphoid tissue-resident langerin + dendritic cells, and monocytes that can be induced by local environmental stimuli to acquire a Langerhans cell phenotype. (medscape.com)

Accumulate2

• It provides striking evidence of cancer evolution in action, with cancer cells able to lie dormant to avoid treatment, and then to accumulate new mutations capable of driving a new bout of disease. (worldhealth.net)
• With the B-cells, functional germinal centers in the lymphoid organs and protective antibodies become rarer, and age-associated B-cells accumulate. (medscape.com)

Genetic14

• To achieve this, they used an adapted strategy that consisted of reprogramming cells using a specific "cocktail" of six genetic factors, while erasing signs of aging. (eurekalert.org)
• But they also found many new genetic changes had occurred in the cancer cells when the patient relapsed. (worldhealth.net)
• The study assessed the genetic expression patterns of chemically treated cells compared to aged human-origin cells and OSK(MYC)-induced murine and human iPSC. (news-medical.net)
• To prove that, the team relied on genetic engineering, creating breeds of mice in which they could tag, and selectively destroy, any cell expressing a biomarker of senescence. (technologyreview.com)
• His lab specializes in optimizing methods for single-cell sequencing, an increasingly popular approach to analysis that homes in on the genetic expression and molecular dynamics of individual cells. (scitechdaily.com)
• Research has shed new light on genetic processes that may one day lead to the development of therapies that can slow, or even reverse, how our cells age. (neurosciencenews.com)
• Significantly, the team found that disrupting these genetic processes could reverse signs of ageing in cells. (neurosciencenews.com)
• Professor Lorna Harries, of the University of Exeter Medical School, who led the research, said: "We're really excited by the discovery that disrupting targeted genetic processes can bring about at least a partial reversal of key elements of the ageing process in human cells. (neurosciencenews.com)
• It's still early days and we need to understand far more about the complex relationships of how our cells and genetic processes influence ageing, yet it's an exciting contribution to how we may one day be able to influence healthier ageing. (neurosciencenews.com)
• cbtabs][cbtab title="MLA"]University of Exeter"Disrupting Genetic Processes Reverses Aging in Human Cells. (neurosciencenews.com)
• Retrieved September 13, 2018 from https://neurosciencenews.com/aging-genetic-disruption-9858/[/cbtab][cbtab title="Chicago"]University of Exeter"Disrupting Genetic Processes Reverses Aging in Human Cells. (neurosciencenews.com)
• https://neurosciencenews.com/aging-genetic-disruption-9858/ (accessed September 13, 2018). (neurosciencenews.com)
• Under the influence of genetic stop-and-go signals, the composition of the T-cell population also changes over the course of our lives. (medscape.com)
• Using novel stem cell, reprogramming and genome editing technologies we are studying how genetic pathways involved in aging and neurodegenerative disease affect formation and function of neural cells. (lu.se)

Senescence10

• The research, "Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence," is published in the journal BMC Cell Biology . (sciencedaily.com)
• Until now, research results demonstrated that senescence (the final stage of cellular aging) was an obstacle blocking the use of this technique for therapeutic applications in elderly patients. (eurekalert.org)
• The NCC system was developed to identify small molecules that reverse the effects of aging and senescence. (news-medical.net)
• Because aging has been demonstrated to be directly related to the occurrence of cardiac disorders, in the present study, the ability of naringenin to prevent cardiac cell senescence was investigated. (hindawi.com)
• Relevant cellular senescence markers, such as X-gal staining, cell cycle regulator levels, and the percentage of cell cycle-arrested cells, were found to be reduced in the presence of naringenin. (hindawi.com)
• To the best of our knowledge, the effect of Nar in cardiac cell senescence has not yet been studied. (hindawi.com)
• Various cellular senescence hallmarks (the percentage of X-gal staining cells, the mRNA levels of the p16 and p21 cell cycle regulators, and the percentage of cell cycle-arrested cells) were investigated. (hindawi.com)
• What he found was that if cells were blocked from entering a state of senescence, the early symptoms of old age were mostly avoided. (technologyreview.com)
• That work, published in 2011, offered compelling evidence of a link between senescence and aging symptoms. (technologyreview.com)
• Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis , Cell Metabolism , Published online January 3, 2019. (nih.gov)

Pluripotent stem3

• These induced pluripotent stem cells (iPSCs) do not require human embryos for their derivation. (scientificamerican.com)
• The team compiled a list of compounds that effectively converted human and mouse somatic cells into chemically induced pluripotent stem cells (CiPSCs) and assessed them using the NCC assay. (news-medical.net)
• Induced pluripotent stem cells viewed under a microscope. (scripps.org)

IPSCs2

• Signs of aging were erased and the iPSCs obtained can produce functional cells, of any type, with an increased proliferation capacity and longevity," explains Jean-Marc Lemaitre who directs the Inserm AVENIR team. (eurekalert.org)
• Our study highlights that increased risk of mutations in iPSCs made from older donors of source cells. (scripps.org)

Biology5

• Even though Life Biosciences and several other startups are investigating Yamanaka factors with a view to reversing human aging, the biology of rejuvenation by reprogramming remains enigmatic and opaque, at best. (scientificamerican.com)
• In their research, published in the journal Genome Biology , they highlighted 353 methylation markers that changed with age. (time.com)
• If we ever want to prevent hair loss from happening or resurrect hair growth once you start to lose your hair, we need to focus on maintaining the function of these hair follicle dermal stem cells," says Biernaskie, associate professor of comparative biology and experimental medicine at UCVM, and the Calgary Firefighters Burn Treatment Society Chair in Skin Regeneration and Wound Healing. (ucalgary.ca)
• With studies like this we're starting to get a sense, at the cell-biology level, of what is really happening in this very prevalent disease," said senior author Edward Morrisey, Ph.D., the Robinette Foundation Professor of Medicine, a professor of Cell and Developmental Biology, and director of the Penn-CHOP Lung Biology Institute at Penn Medicine. (worldhealth.net)
• and (ii) to show whether any differences in the rate of change of age dependence could be influenced by diversity in behaviour and lifestyle , especially with regard to the prevalence of HIV infection , rather than by a fundamental variation in cancer biology between the populations . (bvsalud.org)

Diseases18

• The zeal is shared by Joan Mannick, head of R&D at Life Biosciences, who says partial reprogramming could be potentially "transformative" when it comes to treating or even preventing age-related diseases. (scientificamerican.com)
• New Research on Cell Aging and Death reviews previous literature to describe the main behavioral and biochemical characteristics of the SAMP8 mouse model, discussing its main advantages as well as potential weaknesses to model age-related diseases. (novapublishers.com)
• While additional studies are needed to determine the safety and efficacy, we hope that they will be able to extend health span and delay the onset of multiple age-related diseases and disabilities. (sciencedaily.com)
• This review focuses on an emerging topic, the functional involvement of AQPs in ROS membrane transport, with specific regard to the movement of hydrogen peroxide and NO into and out of cells, in both health and oxidative stress-induced diseases. (hindawi.com)
• Cell aging contributes to functional decline of tissues and organs and increases the risk of chronic diseases such as Alzheimer's disease, atherosclerosis, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, osteoarthritis and osteoporosis. (mayo.edu)
• A professor at Worcester Polytechnic Institute (WPI) is exploring aging on the molecular level, examining how the lipids found in our bodies, particularly those in our cell membranes, change as we age, and how those changes may affect our propensity for age-related diseases, including Alzheimer's disease. (wpi.edu)
• A better understanding of those processes could lead to the development of new medications or lipid replacement to alleviate or eliminate some diseases, helping people stay stronger and more mobile and have better health as they age into their 90s. (wpi.edu)
• She also wants to understand how those changes impair the cells' normal functioning, leaving them prone to cell death or diseases. (wpi.edu)
• If we can systematically characterize the different cells and their dynamics using this novel technique, we may get a panoramic view of the mechanisms of many diseases and the enigma of aging. (scitechdaily.com)
• Our ultimate goal is to help people avoid some of the diseases partially caused by ageing cells, such as dementia and cancer. (neurosciencenews.com)
• This could also be done with other tissues in the body to develop treatments for age-related diseases such as diabetes, they argue. (zmescience.com)
• However, the use of stem cells to treat diseases is still extremely limited in the present day. (zmescience.com)
• LEIPZIG, GERMANY - With age comes illness: Cancer, cardiovascular and neurodegenerative diseases, increased infections, and autoimmune diseases such as rheumatism become more common. (medscape.com)
• In the case of autoimmune diseases, this aging happens particularly quickly. (medscape.com)
• In our group we are interested in how aging and neurodegenerative diseases affect the brain, neural cells and neural stem cells. (lu.se)
• T cells help the body fight diseases or harmful substances, such as bacteria or viruses. (medlineplus.gov)
• This is particularly relevant during ageing and age-related diseases , where drastic changes, generally decreases, in cAMP levels have been associated with the progressive decline in overall cell function and, eventually, the loss of cellular integrity. (bvsalud.org)
• In this review , we explore the connection of single components of the cAMP signalling cascade to ageing and age-related diseases whilst elaborating the literature in the context of cAMP signalling compartmentalization. (bvsalud.org)

Functional6

• Inserm's AVENIR "Genomic plasticity and aging" team, directed by Jean-Marc Lemaitre, Inserm researcher at the Functional Genomics Institute (Inserm/CNRS/Université de Montpellier 1 and 2), has recently succeeded in rejuvenating cells from elderly donors (aged over 100). (eurekalert.org)
• However, as the organism ages, increased metabolic activity can also lead to functional exhaustion of hematopoietic stem cells. (idw-online.de)
• The cell is the basic functional unit of our body, so changes to the cell essentially underlie virtually every disease and the aging process," says Cao, head of the Laboratory of Single-Cell Genomics and Population Dynamics. (scitechdaily.com)
• Gene expression analyses reveal profound changes of CD28(-) T cells in comparison to their CD28(+) counterparts and corroborate their functional differences. (nih.gov)
• As humans age, cells within organs and tissues undergo profound biophysical and biomolecular changes, which significantly influence the rate of progressive functional decline. (aiche.org)
• Characterization analyses conducted at 0 and 2 months of aging detected a loss of surface functional groups over time due to atmospheric oxidation, with MW-NHx possessing less oxygen and greater lung surfactant binding affinity. (cdc.gov)

Cancer17

• Most people by the age of 85 have experienced some kind of chronic illness, and as people get older they are more prone to stroke, heart disease and cancer. (sciencedaily.com)
• Scientists say they have found evidence that cancer cells can go to 'sleep', avoiding the effects of chemotherapy, and then 'reawaken' years later. (worldhealth.net)
• The findings may help scientists to root out these dormant cancer cells, wake them up and kill them. (worldhealth.net)
• The study, published in the journal Leukemia , found that the cancer cells which 'woke up' in the patient after a period of two decades were similar to a group of cancer cells that pre-dated the original bout of the disease. (worldhealth.net)
• This implies that cancer cells had become dormant, resisted chemotherapy and then 'woke up' after many years of rest. (worldhealth.net)
• The cells may have survived because they were growing much more slowly than other cancer cells - and chemotherapy attacks rapidly dividing cells. (worldhealth.net)
• Study leader Professor Mel Greaves, director of the Centre for Evolution and Cancer at The Institute of Cancer Research in London, said the research showed that cancer cells are cunning. (worldhealth.net)
• Blood stem cells regularly fluctuate between being dormant or 'asleep' and dividing very quickly, so it seems cancer cells are just borrowing this trick to avoid being killed by chemotherapy. (worldhealth.net)
• Such accelerated aging may in part explain why breast cancer is so common among women, since cancer is a disease of aging cells. (time.com)
• Normal regulated cell growth is required for life, whereas cancer (neoplasia) results from uncontrolled cell growth. (mayo.edu)
• While Olsen doesn't think age-related changes in the production of phospholipids or the resulting degradation of the cell membranes lead to cancer, she did note that certain lipids found in cell membranes can impact cancer treatment options, such as drug delivery methods. (wpi.edu)
• In addition, since cancer itself can cause changes in cell membranes, doctors might be able to stop its spread if they could prevent those membrane changes by adding certain lipids into a patient's drug regime. (wpi.edu)
• The aging discovery came about by accident, van Deursen says, while he was studying cancer in "progeroid" mice genetically engineered to become old and develop tumors unnaturally fast. (technologyreview.com)
• such as in the surveillance of immune cells and during cancer metastasis. (aiche.org)
• On the other hand, the infiltration of organs by a monoclonal population of aberrant cells, the possibility of lethal evolution, and the cancer-based modalities of successful treatment are all consistent with a neoplastic process. (medscape.com)
• Cancer incidence typically increases with age, but it is not known whether ethnic characteristics influence the age dependence of squamous cell carcinoma of the skin (SCC).Objectives. (bvsalud.org)
• fMWCNTs were characterized during storage, and exposed cells were assessed for several established cancer cell hallmarks. (cdc.gov)

Neurodegeneration1

• Compartmentalized Signaling in Aging and Neurodegeneration. (bvsalud.org)

Vitro3

• They then completed the in vitro reprogramming of the cells. (eurekalert.org)
• An idea just in the planning stage is to select embryonal stem cells (ESCs) in vitro for phenotypes that may retard aging. (jax.org)
• In summary, surface properties of aged fMWCNTs can impact cell transformation events in vitro following continuous, occupationally relevant exposures. (cdc.gov)

Inflammation3

• Here, we demonstrate that autophagy activation is an adaptive survival response to chronic inflammation in the aging bone marrow (BM) niche. (fightaging.org)
• We find that inflammation impairs glucose metabolism and suppresses glycolysis in aged HSCs through Socs3 -mediated impairment of AKT / FoxO -dependent signaling. (fightaging.org)
• Our results identify inflammation-driven glucose hypometabolism as a key driver of HSC dysfunction with age and establish autophagy as a targetable node to reset old HSC glycolytic and regenerative capacity. (fightaging.org)

Molecular7

• After that, the gene is silenced and loses its function, it shows hardly any activity in the stem cells in advanced age," explains Prof. K. Lenhard Rudolph, research group leader at the FLI and professor of molecular medicine at FSU Jena. (idw-online.de)
• Aged hematopoietic stem cells (HSC) exhibit compromised reconstitution capacity and differentiation-bias towards myeloid lineage, however, the molecular mechanism behind it remains not fully understood. (haematologica.org)
• 3 , 4 Although previous studies have identified various molecular signaling pathways promoting HSC aging, 5-8 the exact molecular mechanism is still not fully understood. (haematologica.org)
• The overarching goal of the SD-NSC Human Cell Models of Aging Core is to create and make available powerful, new human cell-based models to enable studies into the molecular and cellular heterogeneity of human aging. (salk.edu)
• Those only capture static information-the current molecular state of a cell at a single moment. (scitechdaily.com)
• Despite this wealth of knowledge, Anna Konturek-Ciesla noted that there is still no consensus about the molecular profile of aged hematopoietic stem cells. (lu.se)
• When we looked at our data, we noticed a pattern of stress-induced changes in gene activity, especially in cells exposed to higher temperatures during isolation," explains David Bryder, Professor of Molecular Hematology at Lund University, and research group leader at Lund Stem Cell Center. (lu.se)

Frailty1

• Moreover, increased ROS and reduced nitric oxide (NO) bioavailability are main key factors in dysfunctions underlying aging, frailty, hypertension, and atherosclerosis. (hindawi.com)

Therapies3

• The discovery has the potential to lead to therapies which could help people age better, without experiencing some of the degenerative effects of getting old. (sciencedaily.com)
• But if we were able to understand it sufficiently well, new therapies could be developed to improve health in old age. (idw-online.de)
• This suggests that they could be an important aspect in designing therapies that could keep us healthier as we age. (neurosciencenews.com)

Proliferation9

• Further investigations revealed that cell proliferation dropped in line with declining levels of ERBB2 on the cardiomyocyte membranes. (worldhealth.net)
• This issue is of particular relevance since changes in NO release could play an important role in endothelial function maintenance, in addition to regulating proliferation of smooth muscle cells, leukocyte adhesion, platelet aggregation, angiogenesis, thrombosis, vascular tone, and hemodynamics. (hindawi.com)
• We were able to quantify cellular proliferation and differentiation rates of many cell types across the entire brain in a single experiment, which wasn't possible using conventional approaches," Cao says. (scitechdaily.com)
• CD28, a major co-stimulatory receptor, is responsible for the optimal antigen-mediated T-cell activation, proliferation and survival of T cells. (nih.gov)
• CD28(-) T cells exhibit reduced antigen receptor diversity, defective antigen-induced proliferation and a shorter replicative lifespan while showing enhanced cytotoxicity and regulatory functions. (nih.gov)
• Multinucleate cell angiohistiocytoma is a benign fibrohistiocytic and vascular proliferation that was first reported by Smith and Wilson Jones in 1985. (medscape.com)
• Puig et al propose the existence of an interaction between mast cells and factor XIIIa-positive fibrohistiocytic cells, which might contribute to vascular proliferation by the release of various proangiogenic cytokines. (medscape.com)
• Puig L, Fernandez-Figueras MT, Bielsa I, Lloveras B, Alomar A. Multinucleate cell angiohistiocytoma: a fibrohistiocytic proliferation with increased mast cell numbers and vascular hyperplasia. (medscape.com)
• Following 8 weeks of exposure, all fMWCNT-exposed cells exhibited significant increased proliferation compared to controls at 7 d post-treatment, while UFCB- and ASB-exposed cells did not differ significantly from controls. (cdc.gov)

Bone marrow7

• Blood and bone marrow samples were taken from the patient when he was diagnosed with a rare form of leukaemia at four years old and compared to samples taken when he relapsed aged 25. (worldhealth.net)
• The hematopoietic stem cells in the bone marrow continuously ensure that the blood system is supplied with new cells throughout life and that in stressful conditions, such as infections, inflammations or bleeding, the production of the required blood cells can then be initiated immediately. (idw-online.de)
• Hematopoietic stem cells in the bone marrow give rise to red blood cells and immune cells . (fightaging.org)
• While the reduced formation of naïve T-cells can be attributed to the regression of the thymus gland, the naïve B-cells are a consequence of age-related, fatty bone marrow degeneration. (medscape.com)
• The influence of adipocyte-derived tumor necrosis factor (TNF)-α also causes the bone marrow to develop B-cells more and more weakly and slowly. (medscape.com)
• They are released more often from the bone marrow, produce more cytokines, and essentially contribute to inflamm-aging. (medscape.com)
• Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the presence of cells with characteristics similar to bone marrow-derived Langerhans cells juxtaposed against a backdrop of hematopoietic cells, including T-cells, macrophages, and eosinophils. (medscape.com)

Dysfunction4

• Aging of the hematopoietic system promotes various blood, immune, and systemic disorders and is largely driven by hematopoietic stem cell (HSC) dysfunction. (fightaging.org)
• The combination of dasatinib and quercetin was recently shown to prevent cell damage , delay physical dysfunction, and, when used in naturally aging mice, extend their life span. (nih.gov)
• Therefore, our aims are to develop cellular models of human neural aging and degeneration, to investigate underlying mechanisms responsible for dysfunction in neural and neural stem cells in the aging and diseased brain and to dissect the regulation of normal neurogenesis. (lu.se)
• Arguments supporting the reactive nature of LCH include the occurrence of spontaneous remissions, the extensive elaboration of multiple cytokines by dendritic cells and T-cells (the so-called cytokine storm) in LCH lesions, and the good survival rate in patients without organ dysfunction. (medscape.com)

Phenotypes2

• Interestingly, interventions involving extracellular signals have been shown to partially reverse some of the aging phenotypes. (nature.com)
• Create induced cell models that maintain age-related phenotypes. (salk.edu)

Stem cell th3

• Stem cell therapy - a technique that relies on the idea that stem cells can be prompted to turn into cartilage cells that will grow and repair damage - is another possible avenue for future treatment. (fightaging.org)
• Vangsness and his colleagues are testing a stem cell therapy developed by Osiris Therapeutics. (fightaging.org)
• Fleischmann calls that concept "pie in the sky" but says that years from now doctors might have injectable stem cell therapy or some other technique that could hold the line on osteoporosis. (fightaging.org)

Hematopoietic stem1

• The Igf2bp2-gene drives growth and metabolic activity at a young age but these activities contribute to the age-associated loss of hematopoietic stem cell function in later life. (idw-online.de)

Person's3

• Scientific data now indicate that prolonged psychological stress might cause a person's cells to age, and possibly die, significantly faster than normal. (sciencenews.org)
• Scientists have used body substances like saliva and studied chromosome changes as markers for aging, but the UCLA team found that methylation, a process that dividing cells use to make subtle changes in the way DNA is expressed, can more accurately determine a cell's - and therefore a person's - age, without the help of a birth certificate. (time.com)
• Hematopoietic stem cells, known as blood stem cells, are crucial for producing all types of blood cells throughout a person's life. (lu.se)

Organs4

• This is one reason why tissues and organs become susceptible to disease as we age. (sciencedaily.com)
• This technique has uncovered shifts in cell production in aging brains and has broader applications for studying cell dynamics across various organs. (scitechdaily.com)
• Cao studies how tissues and organs maintain stable populations of cells-a hallmark of health-so he and his team wanted to investigate how different cellular populations develop, and whether these varied neuronal cells decline in the same way or forge different paths. (scitechdaily.com)
• Infinity Clinic uses fetal stem cells that are intended to form different organs of the fetus in order to stimulate self-renewal and regeneration of corresponding organs of the patient. (placidway.com)

20181

• According to CDC's Active Bacterial Core surveillance (ABCs) data in 2018-2019, IPD incidence was 24 per 100,000 population with a case-fatality ratio of 14% in adults aged ≥65 years. (cdc.gov)

Regenerative medicine1

• The results represent significant progress for research into iPSC cells and a further step forwards for regenerative medicine. (eurekalert.org)

Immune system6

• Cells that reproduce the most-such as those in the skin, lungs and parts of our immune system-are most affected by telomere shortening. (elephantjournal.com)
• The main advantage of our treatment is that prior to administration fetal stem cell-based therapy, we perform immunomodulation procedure developed by our scientists to prevent rejection of fetal stem cells by immune system of the patient. (placidway.com)
• This is because the immune system also ages. (medscape.com)
• In healthy people, the immune system begins to age at age 20. (medscape.com)
• At age 50 years, the aging process of the immune system gains momentum. (medscape.com)
• As we age, the immune system restructures itself completely. (medscape.com)

Mice9

• These senolytic agents alleviated a range of age- and disease-related problems in mice. (sciencedaily.com)
• Professor Tzahor's team conducted a study on mice to determine ERBB2's role in hear cell regeneration. (worldhealth.net)
• Newborn mice are able to regenerate damaged cardiomyocytes (heart muscle cells) however this ability is lost by the time they are just 7-days-old. (worldhealth.net)
• Surprisingly, mice in which the gene is mutated show a reduction in the age-associated loss of function of the blood stem cells in late life, even though the gene is no longer active. (idw-online.de)
• The experimental findings of the current study suggest that the activation of growth and metabolism in juvenile mice preprograms the subsequent loss of function of hematopoietic stem cells and inscribes this into the cell's memory. (idw-online.de)
• Using this expertise, the scientists were able to identify a new subset of hematopoietic stem cells that exhibit particularly strong activity of Igf2bp2-dependent metabolism and growth in adolescent mice. (idw-online.de)
• No significant alteration of hematopoietic homeostasis and HSC function is observed in young Pus10-/- mice, while aged Pus10-/- mice exhibit mild alteration of hematopoietic homeostasis and HSC function. (haematologica.org)
• When the mice were 12 months old, equivalent to around 45 in human years, they were injected with a drug that cleared away the marked cells. (technologyreview.com)
• Although the maximum age the mice lived to was not greatly altered-they didn't turn into furry Methuselas-more of the treated mice than the untreated mice lived to a ripe old age. (technologyreview.com)

Donors6

• tested on cells taken from donors over the age of 100. (eurekalert.org)
• The results obtained led the research team to test the cocktail on even older cells taken from donors of 92, 94 and 96, and even up to 101 years old. (eurekalert.org)
• Our strategy worked on cells taken from donors in their 100s. (eurekalert.org)
• Yamanaka's technique, which can even generate biologically youthful stem cells from centenarian donors, has been extensively studied over the past 15 years. (scientificamerican.com)
• In the new study, Morrisey and his team uncovered evidence of RASCs while examining gene-activity signatures of lung cells sampled from healthy human donors. (worldhealth.net)
• Looking further into these findings, we plotted the trajectories of individual cells across all ages, and found that there was a high decree os cellular heterogeneity among cells, with some cells from elderly donors exhibiting highly-motile features, and vice versa. (aiche.org)

Cytokine2

• We predict that ABCs could be playing a role throughout γHV68 infection due to their long-term persistence, activation of T cells, and continuous cytokine and antibody production. (nature.com)
• As Dörner emphasized, these cells are not under the command of the B-cell receptor and are independent of the cytokine BAFF (B-cell activating factor). (medscape.com)

Anti-Aging10

• These results have spurred interest in translating insights from animal models into anti-aging interventions. (scientificamerican.com)
• The research does, however, hint that methylation may be an important part of aging, and teasing apart how cells regulate that process could help to explain aging, as well as suggest ways to intervene with anti-aging strategies. (time.com)
• Science has finally opened the door to healthy anti-aging solutions. (elephantjournal.com)
• The mouse on the right appears younger after receiving a new anti-aging treatment. (technologyreview.com)
• David and Nelsen acknowledge that the hunt for anti-aging drugs has not yet proved successful, with earlier startups like Sirtris and Elixir Pharmaceuticals eventually flopping. (technologyreview.com)
• Women tend to look for various anti-aging programs once they reach mid-thirties. (placidway.com)
• It is important to start early to gain better results out of the anti-aging procedures. (placidway.com)
• WHile there are a lot of anti-aging program Infinity Clinic is proving you at an affordable price, Female Anti-Aging Program is a popular choice amongst women all around the world. (placidway.com)
• Female Anti-Aging Program is a powerful approach for rejuvenation created in joint effort of our doctors and scientists in order to increase quality of life of the patients of Infinity Clinic. (placidway.com)
• Aim of the Female Anti-Aging Program is to restore exhausted pools of stem cells by introduction of the fetal stem cells. (placidway.com)

Decline2

• This ability to regenerate diminishes with age, not because of a decline in the number of resident stem cells, but because stem cells in the older muscle don't respond when damage occurs. (ca.gov)
• Here we review recent advances in our understanding of CD28(-) T cells and their role in the age-associated decline of immune function. (nih.gov)

Rejuvenation2

• Taken together, this study for the first time evaluated the role of PUS10 in HSC aging and function, and provided a novel insight into HSC rejuvenation and its clinical application. (haematologica.org)
• We have proved that cells can be rejuvenated without losing their function and that rejuvenation looks to restore some function to old cells. (zmescience.com)

Scientists3

• This first research isn't quite stem cell science, but it's both worthy of attention and something we're probably going to see much more of as scientists get better at this - the use of somewhat differentiated precursor cells. (fightaging.org)
• The scientists showed that RASCs have stem-cell-like properties enabling them to regenerate other cells that are essential for the normal functioning of alveoli. (worldhealth.net)
• She is exploring whether scientists can create lipid replacement treatments to alter the lipid composition in membranes to improve how well cells absorb and use medications. (wpi.edu)

Homeostasis3

• Transport of NO and ROS by AQPs would be required for cell homeostasis to play a critical role in maintaining endothelial function. (hindawi.com)
• The accumulation of CD28(-) T cells, particularly within the CD8 subset, is one of the most prominent changes during T-cell homeostasis and function associated with aging in humans. (nih.gov)
• The cyclic AMP (cAMP) signalling cascade is necessary for cell homeostasis and plays important roles in many processes. (bvsalud.org)

Contributes2

• The activity of the metabolism and of growth signals contributes decisively to the development of stem cell function. (idw-online.de)
• We know cell damage contributes to aging but we don't know the exact details of what is going wrong," said Olsen. (wpi.edu)

Signaling2

• In addition, cardiac markers of aging-induced damage, including radical oxidative species levels, mitochondrial metabolic activity, mitochondrial calcium buffer capacity, and estrogenic signaling functions, were also modulated by the compound. (hindawi.com)
• Moreover, we observed that PUS10 is ubiquitinated by E3 ubiquitin ligase CRL4DCAF1 complex and the increase of PUS10 in aged HSPC is due to aging-declined CRL4DCAF1- mediated ubiquitination degradation signaling. (haematologica.org)

Pathways1

• In addition, some pathways that are typically altered during cardiac aging-induced damage, including the generation of radical oxidative species, the mitochondrial metabolic activity, the modulation of the mitochondrial calcium buffering capacity, and the regulation of estradiol and estrogen-regulated gene expression, were investigated [ 20 - 22 ]. (hindawi.com)

Regeneration1

• As well as helping shift the direction of research into hair loss, the findings have wider implications for understanding healthy aging, skin regeneration, and wound healing. (ucalgary.ca)

Dermal4

• Wisoo Shin is lead author on a paper published in Developmental Cell on dermal skin cells. (ucalgary.ca)
• In a paper published in Developmental Cell , Dr. Jeff Biernaskie, PhD, and his team, led by graduate student Wisoo Shin (pictured above), demonstrate that with increasing age, these dermal stem cells become dysfunctional and lose their ability to self-renew. (ucalgary.ca)
• Jeff Biernaskie's team discovered that hair follicle dermal stem cells may be responsible for hair loss. (ucalgary.ca)
• We found that with the hair follicle dermal stem cells, not only are the numbers declining, but their ability to acquire certain functions is also impaired. (ucalgary.ca)

Sickle1

• Age trends in the prevalence of the sickle cell trait. (cdc.gov)

Murine1

• Built upon scDiffCom, scAgeCom is an atlas of age-related cell-cell communication changes covering 23 mouse tissues from 58 single-cell RNA sequencing datasets from Tabula Muris Senis and the Calico murine aging cell atlas. (nature.com)

Signatures2

• You erase all of these signatures that look like aging or any abnormal signatures, and [cells are] being reset essentially to the baseline 'perfect' epigenome," Meissner says. (scientificamerican.com)
• This will be iPSC-derived organoids initially, but over time will involve integration of directly converted cells that maintain aging signatures. (salk.edu)

Metabolic3

• Could Metabolic Syndrome, Lipodystrophy, and Aging Be Mesenchymal Stem Cell Exhaustion Syndromes? (cellmedicine.com)
• The study results show that a certain growth and metabolic activity is necessary for the undisturbed development of our blood stem cells. (idw-online.de)
• We learned how the T-cell aging process translates into metabolic reprogramming of the T-cells - how a good, strong, and protective T-cell transforms into a disease-inducing T-cell. (medscape.com)

Younger7

• A new way to rejuvenate old cells in the laboratory, making them not only look younger, but start to behave more like young cells, has now been discovered. (sciencedaily.com)
• Within hours, the cells looked younger and started to rejuvenate, behaving like young cells and dividing. (sciencedaily.com)
• Many times when i was younger, my cell phone i believe saved my life. (answerbag.com)
• Activating the enzyme telomerase within our own cells is a scientifically proven way to address telomere shortening and encourage cells to function as though they were younger. (elephantjournal.com)
• Midnight Serum has been formulated to support skins own cell renewal process so you can wake up to younger looking skin. (boots.com)
• Summary: Resveratrol analogues appears to switch splicing factors back on, causing cells to look younger, start rejuvenating and behaving like young cells within hours of exposure, a new study reports. (neurosciencenews.com)
• Children, especially those younger than 5 years and those age and influenza B Victoria lineage components are with certain underlying medical conditions, can experience unchanged from the previous season. (cdc.gov)

Rejuvenate1

• The goal is to find drugs that that can sustain or rejuvenate fibroblast function well into old age. (ucalgary.ca)

Research12

• Dr Eva Latorre, Research Associate at the University of Exeter, who carried out the experiments, was surprised by the extent and rapidity of the changes in the cells. (sciencedaily.com)
• On January 19, co-founders Rick Klausner and Hans Bishop publicly launched an aging research initiative called Altos Labs, with $3 billion in initial financing from backers including tech investor Yuri Milner and Amazon founder Jeff Bezos. (scientificamerican.com)
• However, research conducted by Professor Eldad Tzahor of the Weizmann Institute of Science's Biological Regulation Department, suggests that a protein called ERBB2 may hold the key to regenerating heart cells. (worldhealth.net)
• Australia's Senate voted on Tuesday to allow cloned stem cells to be used for medical research after an emotional and divisive debate on relaxing restrictions on research. (fightaging.org)
• The bill passed by two votes in the 76-seat Senate and will now go to the lower house of parliament in late November, where supporters believe they can muster the numbers to overturn existing bans on research on cloned stem cells. (fightaging.org)
• ST. LOUIS Missouri voters have narrowly approved a state constitutional amendment that protects stem cell research, even involving the use of human embryos. (fightaging.org)
• The amendment guarantees that any federally-allowed stem cell research and treatments can be carried out in Missouri. (fightaging.org)
• There is a growing portfolio of research that suggests telomeres -the tiny caps at the end of each strand of our DNA-may hold the key to understanding why our bodies age and how we may be able to slow or even reverse the cellular aging process. (elephantjournal.com)
• Further research indicates that, by activating telomerase, we may be able to slow, stop or perhaps even reverse the telomere shortening that occurs as we age. (elephantjournal.com)
• The research is already the basis of a biotechnology company called Unity, cofounded by van Deursen and Judith Campisi, of the Buck Institute for Research on Aging, who has pursued related research. (technologyreview.com)
• Dr Eva Latorre, of the University of Exeter Medical School, who carried out the research, said: "This study is part of a fast-evolving body of work into how we age. (neurosciencenews.com)
• Anna Konturek-Ciesla, a researcher at Lund Stem Cell Center and the lead author of the study explains, "In our research, which focuses on hematopoiesis, or blood cell formation, many studies have attempted to analyze the changes associated with aging in blood stem cells using gene expression profiling. (lu.se)

Gene8

• With a fluorescent reporter gene-expressing γHV68 we demonstrate that ABCs are infected with γHV68 at similar rates to other previously activated B cells. (nature.com)
• The gene Igf2bp2 is important in youth for the full function of these cells, as it activates their growth and metabolism. (idw-online.de)
• When the gene is missing, however, the aging-associated loss of function of the stem cells is surprisingly diminished. (idw-online.de)
• The eventual aging of hematopoietic stem cells is apparently already preprogrammed by their gene-driven growth in youth. (idw-online.de)
• This suggests that Igf2bp2 gene function in early life leads to the aging of the stem cells. (idw-online.de)
• Observations of gene-activity similarities between RASCs and an important progenitor cell in alveoli called AT2 cells led the team to a further discovery: RASCs, in addition to their secretory function, serve as predecessors for AT2 cells -- regenerating them to maintain the AT2 population and keep alveoli healthy. (worldhealth.net)
• Studying gene expression is essential for understanding how cells function and respond to different stimuli. (lu.se)
• Today, performing gene expression analysis on young and aged hematopoietic stem cells is a common practice, used to understand the changes associated with aging. (lu.se)

Years17

• But in recent years, Yamanaka factors have also become the focus for another burgeoning area: to set back the clock on aging. (scientificamerican.com)
• Throughout the years, ROS and NO have been widely considered to enter cells by freely diffusing through the cell membrane lipid bilayer and not via specific transporters or channels. (hindawi.com)
• For the past three years, she's studied the connection between plasmalogens, a type of lipid found in cell membranes, and Alzheimer's. (wpi.edu)
• Reported cases of multinucleate cell angiohistiocytoma have occurred in patients aged 24-74 years. (medscape.com)
• Should a dose of PCV20 be recommended for U.S. adults aged ≥65 years who have previously received both PCV13 and PPSV23? (cdc.gov)
• The reported incidence of all-cause pneumonia hospitalization among U.S. adults aged ≥65 years ranges from 847-3,365 per 100,000 population * [1]. (cdc.gov)
• According to a prospective multicenter surveillance study during 2013-2016, the serotypes contained in PCV13 and PCV20 caused 4.2% and 7.0%, respectively, of all-cause community-acquired pneumonia hospitalizations in adults aged ≥65 years [2]. (cdc.gov)
• In 2014, routine use of the PCV13 was recommended for all adults aged ≥65 years, in addition to PPSV23 that had already been recommended. (cdc.gov)
• Among Medicare Part A/B beneficiaries aged ≥65 years, 47% received at least one dose of PCV13, and 30% received both PCV13 and PPSV23 (Centers for Medicare & Medicaid [CMS] unpublished data) in 2020. (cdc.gov)
• Evaluation of the BNT162b2 Covid-19 vaccine in children 5 to 11 years of age. (cdc.gov)
• Linear regression analysis was applied to the logarithm of the age-specific incidence rates for SCC v. the logarithm of age between 35 and 74 years. (bvsalud.org)
• Methods: Serum sclerostin, FGF-23, CTX, and P1NP were measured every 2 h over a 24-h interval in ten healthy men aged 20-65 years. (cdc.gov)
• DSN: CC37.HSPHANES.DIABETES ABSTRACT Introduction Hispanic Health and Nutrition Examination Survey Mexican Americans Cuban Americans Puerto Ricans Tape Number 6506 Ages 20 Years - 74 Years Version 1 August 1988 The Hispanic Health and Nutrition Examination Survey (HHANES) was conducted from July 1982 through December 1984. (cdc.gov)
• The following information shows the total number of persons ages 6 months to 74 years sampled, interviewed, and examined in each of the three portions of the survey. (cdc.gov)
• 2,834 examined The data on the tape documented here are for all examined persons ages 20 years to 74 years. (cdc.gov)
• The mean age was 11.2 years and the mean duration of diabetes was 4.0 years. (who.int)
• The and the mean (SD) age was not significantly association of type 1 diabetes and coeliac different from the study patients [11.2 (5.1) disease has been widely reported, the latter versus 11.7 (4.7) years]. (who.int)

Study3

• This groundbreaking work, led by co-first authors Ziyu Lu and Melissa Zhang from Cao's lab, promises to influence not only the study of the brain but also broader aspects of aging and disease across the human body. (scitechdaily.com)
• The study, published in the FASEB Journal, was conducted in human cells in laboratories. (neurosciencenews.com)
• Multinucleate cell angiohistiocytoma: A clinicopathologic study of 62 cases and proposed diagnostic criteria. (medscape.com)

Blood stem cells3

• Throughout one's life, the blood is constantly being replenished from blood stem cells. (idw-online.de)
• However, these two processes simultaneously burn themselves into our cells as a kind of memory and then contribute to the loss of function of the blood stem cells later in life," postulates Prof. Rudolph. (idw-online.de)
• Blood stem cells, in particular, lose some of their functionality over time, contributing to various blood disorders and disease-related conditions. (lu.se)

Mutation1

• Any time a cell divides, there is a risk of a mutation occurring. (scripps.org)

Subset2

• With age, a subset of HSCs increases autophagy flux and preserves some regenerative capacity, while the rest fail to engage autophagy and become metabolically overactivated and dysfunctional. (fightaging.org)
• The slopes of the regression (age exponent) were compared for each subset of gender , population group and year of diagnosis (between 2000 and 2010).Results. (bvsalud.org)

Metabolism1

• Results were reported in Cell Metabolism . (nih.gov)

20211

• Cells;10(2)2021 02 22. (bvsalud.org)

Methylation3

• During methylation, cells pull in methyl groups to sit on top of DNA, which can impair or enhance the activity of that section of DNA. (time.com)
• So Steve Horvath, a professor of human genetics at the David Geffen School of Medicine at UCLA and his team figured that methylation would be a good stand-in for how old cells were. (time.com)
• He stresses, however, that for now, the connection between methylation and age is only that - an association, and not a causal link. (time.com)

Time7

• Each time a cell divides, enzymes chew off a tiny portion of its telomeres. (sciencenews.org)
• While we can see the passing of time by looking in the mirror, a much closer look reveals how a ticking clock deep within our cells affects our aging. (elephantjournal.com)
• Olsen, the Leonard P. Kinnicutt Assistant Professor of Chemistry and Biochemistry, says the key to healthy aging could lie with the maintenance of membranes over time, affecting the health of cell membranes. (wpi.edu)
• This is a 92 hour time capture image from NHDF cells treated with DMSO and 92 hour time capture image showing NHDF cells treated with resveratrol. (neurosciencenews.com)
• If you decide that it's time to give your child their own phone, be sure to have a conversation with them about cell phone safety and appropriate use. (notepage.net)
• In her cellular and microbiological investigations, Weyand has devoted a lot of time to studying why T-cells age prematurely in patients with RA. (medscape.com)
• Some Work Group members expressed that the interpretation varies depending on factors such as time since the last vaccination, age, or the presence of underlying medical conditions. (cdc.gov)