Bordetella parapertussis
Bordetella
Bordetella pertussis
Bordetella bronchiseptica
Whooping Cough
Pertussis Vaccine
Virulence Factors, Bordetella
Pertussis Toxin
O Antigens
Species Specificity
Bordetella avium
Molecular Sequence Data
Hemagglutinins
PFGE and pertactin gene sequencing suggest limited genetic variability within the Finnish Bordetella parapertussis population. (1/39)
The outer-membrane protein pertactin (Prn) of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica is believed to function as an adhesin and is an important immunogen. The emergence of B. pertussis and B. bronchiseptica Prn variants has been reported. The aim of this study was to determine whether similar variation is found in B. parapertussis Prn and to characterize Finnish clinical B. parapertussis isolates that were collected in 1982-2000. Of 76 B. parapertussis isolates studied, seven (9 %) were found to have silent and non-silent nucleotide changes. In addition, one (1 %) had eight PQP repeats instead of nine. Three closely related B. parapertussis XbaI PFGE patterns were found. Genetic variation of B. parapertussis was found to be very limited, suggesting that B. parapertussis is a stable organism that is well-adapted to its own ecological niche. (+info)Comparison of culture and PCR for detection of Bordetella pertussis and Bordetella parapertussis under routine laboratory conditions. (2/39)
A PCR assay for the detection of Bordetella pertussis and Bordetella parapertussis was compared with the conventional culture method under routine laboratory conditions. Detection of B. pertussis was based on the amplification of a section of the IS481 insertion sequence and confirmation of positive results was based on a sequence of the pertussis toxin promoter region. Detection of B. parapertussis was based on the amplification of a section of the IS1001 insertion sequence. An internal control was included. Data were available for the period 28 November 2000 to 9 July 2003. In this period, 3096 patients were examined for infection with B. pertussis and B. parapertussis by culture and PCR on the same day. B. pertussis was found in 496 (16 %) patients; 208 (42 %) were diagnosed by PCR alone whereas 17 (3 %) were diagnosed by culture alone. B. parapertussis was found in 64 (2 %) patients. The sensitivity of the PCR was 97 % and of culture 58 %. The specificity of PCR was 93 % when regarding culture as 100 % sensitive. There was a significant relationship between laboratory method and age, as the superiority of PCR was most marked in the age group 0.5-3 years. The PCR assay proved highly sensitive for the diagnosis of pertussis. The specificity estimate of the PCR assay suffers from the influence of a gold-standard method with a low sensitivity. The PCR assay is considered highly specific due to the amplification of two different sequences in two separate assays. (+info)The BvgAS signal transduction system regulates biofilm development in Bordetella. (3/39)
The majority of Bordetella sp. virulence determinants are regulated by the BvgAS signal transduction system. BvgAS mediates the control of multiple phenotypic phases and a spectrum of gene expression profiles specific to each phase in response to incremental changes in the concentrations of environmental signals. Studies highlighting the critical role of this signaling circuitry in the Bordetella infectious cycle have focused on planktonically growing bacterial cells. It is becoming increasingly clear that the major mode of bacterial existence in the environment and within the body is a surface-attached state known as a biofilm. Biofilms are defined as consortia of sessile microorganisms that are embedded in a matrix. During routine growth of Bordetella under agitating conditions, we noticed the formation of a bacterial ring at the air-liquid interface of the culture tubes. We show here that this surface adherence property reflects the ability of these organisms to form biofilms. Our data demonstrate that the BvgAS locus regulates biofilm development in Bordetella. The results reported in this study suggest that the Bvg-mediated control in biofilm development is exerted at later time points after the initial attachment of bacteria to the different surfaces. Additionally, we show that these biofilms are highly tolerant of a number of antimicrobials, including the ones that are currently recommended for treatment of veterinary and human infections caused by Bordetella spp. Finally, we discuss the significance of the biofilm lifestyle mode as a potential contributor to persistent infections. (+info)Chromosome-borne class A BOR-1 beta-Lactamase of Bordetella bronchiseptica and Bordetella parapertussis. (4/39)
A narrow-spectrum clavulanic acid-inhibited class A beta-lactamase, BOR-1, was identified in a Bordetella bronchiseptica clinical isolate. It shared 45% amino acid identity with L-2 from Stenotrophomonas maltophilia. An identical beta-lactamase gene was found in B. bronchiseptica and Bordetella parapertussis reference strains that may contribute only in part to their resistance phenotype. (+info)Characterization of the filamentous hemagglutinin-like protein FhaS in Bordetella bronchiseptica. (5/39)
Filamentous hemagglutinin (FHA) is a large (>200 kDa), rod-shaped protein expressed by bordetellae that is both surface-associated and secreted. FHA mediates bacterial adherence to epithelial cells and macrophages in vitro and is absolutely required for tracheal colonization in vivo. The recently sequenced Bordetella bronchiseptica genome revealed the presence of a gene, fhaS, that is nearly identical to fhaB, the FHA structural gene. We show that although fhaS expression requires the BvgAS virulence control system, it is maximal only under a subset of conditions in which BvgAS is active, suggesting an additional level of regulation. We also show that, like FHA, FhaS undergoes a C-terminal proteolytic processing event and is both surface-associated and secreted and that export across the outer membrane requires the channel-forming protein FhaC. Unlike FHA, however, FhaS was unable to mediate adherence of B. bronchiseptica to epithelial cell lines in vitro and was not required for respiratory tract colonization in vivo. In a coinfection experiment, a DeltafhaS strain was out-competed by wild-type B. bronchiseptica, indicating that fhaS is expressed in vivo and that FhaS contributes to bacterial fitness in a manner revealed when the mutant must compete with wild-type bacteria. These data suggest that FHA and FhaS perform distinct functions during the Bordetella infectious cycle. A survey of various Bordetella strains revealed two distinct fhaS alleles that segregate according to pathogen host range and that B. parapertussis(hu) most likely acquired its fhaS allele from B. pertussis horizontally, suggesting fhaS may contribute to host-species specificity. (+info)Clearance of Bordetella parapertussis from the lower respiratory tract requires humoral and cellular immunity. (6/39)
Bordetella parapertussis and Bordetella pertussis are closely related species that cause whooping cough, an acute, immunizing disease. Their coexistence in the same host populations at the same time and vaccine studies showing that B. pertussis vaccines have little effect on B. parapertussis infection or disease suggest that the protective immunity induced by each does not efficiently cross protect against the other. Although the mechanisms of protective immunity to B. pertussis have been well studied, those of B. parapertussis have not. The present study explores the mechanism by which B. parapertussis is cleared from the lower respiratory tract by anamnestic immunity. Serum antibodies are necessary and sufficient for elimination of this bacterium, and CD4(+) T cells, complement, and neutrophils are required for serum antibody-mediated clearance. Mice lacking immunoglobulin A had no defect in their ability to control or clear infection. Interestingly, serum antibody-mediated clearance of B. parapertussis did not require Fc receptors that are required for antibody-mediated clearance of B. pertussis. Together these data support a model for the mechanism of protective immunity to B. parapertussis that is similar but distinct from that of B. pertussis. (+info)Comparative toll-like receptor 4-mediated innate host defense to Bordetella infection. (7/39)
Bordetella pertussis, B. parapertussis, and B. bronchiseptica are closely related species associated with respiratory disease in humans and other mammals. While B. bronchiseptica has a wide host range, B. pertussis and B. parapertussis evolved separately from a B. bronchiseptica-like progenitor to naturally infect only humans. Despite very different doubling times in vitro, all three establish similar levels of infection in the mouse lung within 72 h. Recent work has revealed separate roles for Toll-like receptor 4 (TLR4) in immunity to B. pertussis and B. bronchiseptica, while no role for TLR4 during B. parapertussis infection has been described. Here we compared the requirement for TLR4 in innate host defense to these organisms using the same mouse infection model. While B. bronchiseptica causes lethal disease in TLR4-deficient mice, B. pertussis and B. parapertussis do not. Correspondingly, TLR4 is critical in limiting B. bronchiseptica but not B. pertussis or B. parapertussis bacterial numbers during the first 72 h. Interestingly, B. bronchiseptica induces a TLR4-dependent cytokine response that is considerably larger than that induced by B. pertussis or B. parapertussis. Analysis of their endotoxins using RAW cells suggests that B. bronchiseptica lipopolysaccharide (LPS) is 10- and 100-fold more stimulatory than B. pertussis or B. parapertussis LPS, respectively. The difference in LPS stimulus is more pronounced when using HEK293 cells expressing human TLR4. Thus, it appears that in adapting to infect humans, B. pertussis and B. parapertussis independently modified their LPS to reduce TLR4-mediated responses, which may compensate for slower growth rates and facilitate host colonization. (+info)Characterization of serological responses to pertussis. (8/39)
We have compared the use of five nonvaccine antigens to the use of conventional vaccine antigens, pertussis toxin (PT), and filamentous hemagglutinin (FHA) for the serological diagnosis of pertussis by enzyme-linked immunosorbent assay (ELISA). The nonvaccine antigens included the catalytic region of adenylate cyclase toxin (CatACT), the C-terminal region of FHA (C-FHA), lipooligosaccharide (LOS), the peptidoglycan-associated lipoprotein (PAL), and the BrkA protein. The serological responses of individuals with culture-confirmed pertussis were compared to those of adults with no recent history of a coughing disease. An immunoglobulin G (IgG) ELISA for PT was the most sensitive (92.2%) test for the serodiagnosis of pertussis. Of the nonvaccine antigens, ELISA for IgG responses to CatACT (sensitivity, 62.8%), C-FHA (sensitivity, 39.2%), and LOS IgA (sensitivity, 29.4%) were less sensitive but could also distinguish culture-positive individuals from control individuals. The use of a combination of multiple ELISA targets improved the sensitivity of the assay for serological diagnosis. Elevated IgG and IgA antibody titers persisted for more than a year in the individuals with culture-confirmed pertussis. (+info)'Bordetella parapertussis' is a gram-negative, coccobacillus bacterium that can cause a respiratory infection in humans. It is one of the several species in the genus Bordetella and is closely related to Bordetella pertussis, which causes whooping cough (pertussis).
Bordetella parapertussis infection often results in symptoms similar to those of pertussis but are usually less severe. The illness is sometimes referred to as "mild whooping cough" or "whooping cough-like illness."
The bacterium primarily infects the respiratory tract, attaching to the ciliated epithelial cells lining the airways. This leads to inflammation and damage of the respiratory mucosa, causing a persistent cough, which may be accompanied by paroxysms (intense fits of coughing), inspiratory whoop, and post-tussive vomiting.
Transmission occurs through respiratory droplets when an infected person sneezes or coughs near someone else. The incubation period for Bordetella parapertussis infection is typically 7 to 10 days but can range from 5 to 21 days.
Prevention and control measures include vaccination, good hygiene practices (such as covering the mouth and nose when coughing or sneezing), and early detection and treatment of infected individuals. Antibiotics such as macrolides (e.g., azithromycin, erythromycin) are often used to treat Bordetella parapertussis infections, helping to reduce the duration of symptoms and limit transmission to others.
"Bordetella" is a genus of gram-negative, aerobic bacteria that are known to cause respiratory infections in humans and animals. The most well-known species within this genus is Bordetella pertussis, which is the primary causative agent of whooping cough (pertussis) in humans.
Whooping cough is a highly contagious respiratory infection that is characterized by severe coughing fits, followed by a high-pitched "whoop" sound upon inhalation. The bacteria attach to the cilia lining the respiratory tract and release toxins that damage the cilia and cause inflammation, leading to the characteristic symptoms of the disease.
Other species within the Bordetella genus include Bordetella parapertussis, which can also cause a milder form of whooping cough, and Bordetella bronchiseptica, which is associated with respiratory infections in animals but can occasionally infect humans as well.
Prevention of Bordetella infections typically involves vaccination, with vaccines available for both infants and adults to protect against B. pertussis and B. parapertussis. Good hygiene practices, such as covering the mouth and nose when coughing or sneezing, can also help prevent the spread of these bacteria.
Bordetella infections are caused by bacteria called Bordetella pertussis or Bordetella parapertussis, which result in a highly contagious respiratory infection known as whooping cough or pertussis. These bacteria primarily infect the respiratory cilia (tiny hair-like structures lining the upper airways) and produce toxins that cause inflammation and damage to the respiratory tract.
The infection typically starts with cold-like symptoms, including a runny nose, sneezing, and a mild cough. After about one to two weeks, the cough becomes more severe, leading to episodes of intense, uncontrollable coughing fits that can last for several minutes. These fits often end with a high-pitched "whoop" sound as the person gasps for air. Vomiting may occur following the coughing spells.
Bordetella infections can be particularly severe and even life-threatening in infants, young children, and people with weakened immune systems. Complications include pneumonia, seizures, brain damage, and, in rare cases, death.
Prevention is primarily through vaccination, which is part of the recommended immunization schedule for children. A booster dose is also recommended for adolescents and adults to maintain immunity. Antibiotics can be used to treat Bordetella infections and help prevent the spread of the bacteria to others. However, antibiotics are most effective when started early in the course of the illness.
'Bordetella pertussis' is a gram-negative, coccobacillus bacterium that is the primary cause of whooping cough (pertussis) in humans. This highly infectious disease affects the respiratory system, resulting in severe coughing fits and other symptoms. The bacteria's ability to evade the immune system and attach to ciliated epithelial cells in the respiratory tract contributes to its pathogenicity.
The bacterium produces several virulence factors, including pertussis toxin, filamentous hemagglutinin, fimbriae, and tracheal cytotoxin, which contribute to the colonization and damage of respiratory tissues. The pertussis toxin, in particular, is responsible for many of the clinical manifestations of the disease, such as the characteristic whooping cough and inhibition of immune responses.
Prevention and control measures primarily rely on vaccination using acellular pertussis vaccines (aP) or whole-cell pertussis vaccines (wP), which are included in combination with other antigens in pediatric vaccines. Continuous efforts to improve vaccine efficacy, safety, and coverage are essential for controlling the global burden of whooping cough caused by Bordetella pertussis.
'Bordetella bronchiseptica' is a gram-negative, aerobic bacterium that primarily colonizes the respiratory tract of animals, including dogs, cats, and rabbits. It can also cause respiratory infections in humans, particularly in individuals with compromised immune systems or underlying lung diseases.
The bacterium produces several virulence factors, such as adhesins, toxins, and proteases, which allow it to attach to and damage the ciliated epithelial cells lining the respiratory tract. This can lead to inflammation, bronchitis, pneumonia, and other respiratory complications.
'Bordetella bronchiseptica' is closely related to 'Bordetella pertussis', the bacterium that causes whooping cough in humans. However, while 'Bordetella pertussis' is highly adapted to infecting humans, 'Bordetella bronchiseptica' has a broader host range and can cause disease in a variety of animal species.
In animals, 'Bordetella bronchiseptica' is often associated with kennel cough, a highly contagious respiratory infection that spreads rapidly among dogs in close quarters, such as boarding facilities or dog parks. Vaccines are available to prevent kennel cough caused by 'Bordetella bronchiseptica', and they are often recommended for dogs that are at high risk of exposure.
Whoopering Cough, also known as Pertussis, is a highly contagious respiratory infection caused by the bacterium Bordetella pertussis. It is characterized by severe coughing fits followed by a high-pitched "whoop" sound during inspiration. The disease can affect people of all ages, but it is most dangerous for babies and young children. Symptoms typically develop within 5 to 10 days after exposure and include runny nose, low-grade fever, and a mild cough. After a week or two, the cough becomes more severe and is often followed by vomiting and exhaustion. Complications can be serious, especially in infants, and may include pneumonia, seizures, brain damage, or death. Treatment usually involves antibiotics to kill the bacteria and reduce the severity of symptoms. Vaccination is available and recommended for the prevention of whooping cough.
A Pertussis vaccine is a type of immunization used to protect against pertussis, also known as whooping cough. It contains components that stimulate the immune system to produce antibodies against the bacteria that cause pertussis, Bordetella pertussis. There are two main types of pertussis vaccines: whole-cell pertussis (wP) vaccines and acellular pertussis (aP) vaccines. wP vaccines contain killed whole cells of B. pertussis, while aP vaccines contain specific components of the bacteria, such as pertussis toxin and other antigens. Pertussis vaccines are often combined with diphtheria and tetanus to form combination vaccines, such as DTaP (diphtheria, tetanus, and acellular pertussis) and TdaP (tetanus, diphtheria, and acellular pertussis). These vaccines are typically given to young children as part of their routine immunization schedule.
Virulence factors in Bordetella pertussis, the bacterium that causes whooping cough, refer to the characteristics or components of the organism that contribute to its ability to cause disease. These virulence factors include:
1. Pertussis Toxin (PT): A protein exotoxin that inhibits the immune response and affects the nervous system, leading to the characteristic paroxysmal cough of whooping cough.
2. Adenylate Cyclase Toxin (ACT): A toxin that increases the levels of cAMP in host cells, disrupting their function and contributing to the pathogenesis of the disease.
3. Filamentous Hemagglutinin (FHA): A surface protein that allows the bacterium to adhere to host cells and evade the immune response.
4. Fimbriae: Hair-like appendages on the surface of the bacterium that facilitate adherence to host cells.
5. Pertactin (PRN): A surface protein that also contributes to adherence and is a common component of acellular pertussis vaccines.
6. Dermonecrotic Toxin: A toxin that causes localized tissue damage and necrosis, contributing to the inflammation and symptoms of whooping cough.
7. Tracheal Cytotoxin: A toxin that damages ciliated epithelial cells in the respiratory tract, impairing mucociliary clearance and increasing susceptibility to infection.
These virulence factors work together to enable Bordetella pertussis to colonize the respiratory tract, evade the host immune response, and cause the symptoms of whooping cough.
Pertussis toxin is an exotoxin produced by the bacterium Bordetella pertussis, which is responsible for causing whooping cough in humans. This toxin has several effects on the host organism, including:
1. Adenylyl cyclase activation: Pertussis toxin enters the host cell and modifies a specific G protein (Gαi), leading to the continuous activation of adenylyl cyclase. This results in increased levels of intracellular cAMP, which disrupts various cellular processes.
2. Inhibition of immune response: Pertussis toxin impairs the host's immune response by inhibiting the migration and function of immune cells like neutrophils and macrophages. It also interferes with antigen presentation and T-cell activation, making it difficult for the body to clear the infection.
3. Increased inflammation: The continuous activation of adenylyl cyclase by pertussis toxin leads to increased production of proinflammatory cytokines, contributing to the severe coughing fits and other symptoms associated with whooping cough.
Pertussis toxin is an essential virulence factor for Bordetella pertussis, and its effects contribute significantly to the pathogenesis of whooping cough. Vaccination against pertussis includes inactivated or genetically detoxified forms of pertussis toxin, which provide immunity without causing disease symptoms.
"O antigens" are a type of antigen found on the lipopolysaccharide (LPS) component of the outer membrane of Gram-negative bacteria. The "O" in O antigens stands for "outer" membrane. These antigens are composed of complex carbohydrates and can vary between different strains of the same species of bacteria, which is why they are also referred to as the bacterial "O" somatic antigens.
The O antigens play a crucial role in the virulence and pathogenesis of many Gram-negative bacteria, as they help the bacteria evade the host's immune system by changing the structure of the O antigen, making it difficult for the host to mount an effective immune response against the bacterial infection.
The identification and classification of O antigens are important in epidemiology, clinical microbiology, and vaccine development, as they can be used to differentiate between different strains of bacteria and to develop vaccines that provide protection against specific bacterial infections.
Bacterial antibodies are a type of antibodies produced by the immune system in response to an infection caused by bacteria. These antibodies are proteins that recognize and bind to specific antigens on the surface of the bacterial cells, marking them for destruction by other immune cells. Bacterial antibodies can be classified into several types based on their structure and function, including IgG, IgM, IgA, and IgE. They play a crucial role in the body's defense against bacterial infections and provide immunity to future infections with the same bacteria.
Species specificity is a term used in the field of biology, including medicine, to refer to the characteristic of a biological entity (such as a virus, bacterium, or other microorganism) that allows it to interact exclusively or preferentially with a particular species. This means that the biological entity has a strong affinity for, or is only able to infect, a specific host species.
For example, HIV is specifically adapted to infect human cells and does not typically infect other animal species. Similarly, some bacterial toxins are species-specific and can only affect certain types of animals or humans. This concept is important in understanding the transmission dynamics and host range of various pathogens, as well as in developing targeted therapies and vaccines.
"Bordetella avium" is a gram-negative, rod-shaped bacterium that belongs to the family Alcaligenaceae. It is a respiratory pathogen that primarily affects birds, particularly pigeons and other Columbiformes. The bacterium can cause upper respiratory tract infections, pneumonia, and other respiratory diseases in these birds.
In humans, "Bordetella avium" has been rarely reported as a causative agent of respiratory infections, particularly in individuals with compromised immune systems or underlying lung conditions. However, its clinical significance in human disease is not well established, and further research is needed to determine the true extent of its pathogenicity in humans.
Bacterial DNA refers to the genetic material found in bacteria. It is composed of a double-stranded helix containing four nucleotide bases - adenine (A), thymine (T), guanine (G), and cytosine (C) - that are linked together by phosphodiester bonds. The sequence of these bases in the DNA molecule carries the genetic information necessary for the growth, development, and reproduction of bacteria.
Bacterial DNA is circular in most bacterial species, although some have linear chromosomes. In addition to the main chromosome, many bacteria also contain small circular pieces of DNA called plasmids that can carry additional genes and provide resistance to antibiotics or other environmental stressors.
Unlike eukaryotic cells, which have their DNA enclosed within a nucleus, bacterial DNA is present in the cytoplasm of the cell, where it is in direct contact with the cell's metabolic machinery. This allows for rapid gene expression and regulation in response to changing environmental conditions.
Molecular sequence data refers to the specific arrangement of molecules, most commonly nucleotides in DNA or RNA, or amino acids in proteins, that make up a biological macromolecule. This data is generated through laboratory techniques such as sequencing, and provides information about the exact order of the constituent molecules. This data is crucial in various fields of biology, including genetics, evolution, and molecular biology, allowing for comparisons between different organisms, identification of genetic variations, and studies of gene function and regulation.
Hemagglutinins are proteins found on the surface of some viruses, including influenza viruses. They have the ability to bind to specific receptors on the surface of red blood cells, causing them to clump together (a process known as hemagglutination). This property is what allows certain viruses to infect host cells and cause disease. Hemagglutinins play a crucial role in the infection process of influenza viruses, as they facilitate the virus's entry into host cells by binding to sialic acid receptors on the surface of respiratory epithelial cells. There are 18 different subtypes of hemagglutinin (H1-H18) found in various influenza A viruses, and they are a major target of the immune response to influenza infection. Vaccines against influenza contain hemagglutinins from the specific strains of virus that are predicted to be most prevalent in a given season, and induce immunity by stimulating the production of antibodies that can neutralize the virus.
A base sequence in the context of molecular biology refers to the specific order of nucleotides in a DNA or RNA molecule. In DNA, these nucleotides are adenine (A), guanine (G), cytosine (C), and thymine (T). In RNA, uracil (U) takes the place of thymine. The base sequence contains genetic information that is transcribed into RNA and ultimately translated into proteins. It is the exact order of these bases that determines the genetic code and thus the function of the DNA or RNA molecule.
Bordetella parapertussis
Duncan Maskell
Bordetella pertussis
Mark Achtman
Julian Parkhill
Adenylate cyclase toxin
Bordet-Gengou agar
Pathogenic bacteria
Pertussis toxin
Bordetella
Tracheal cytotoxin
Bordetella trematum
Bordetella bronchiseptica
List of MeSH codes (B03)
Whooping cough
Bordetella parapertussis - Wikipedia
Bordetella pertussis/parapertussis, Culture (5260) | Rady Children's Hospital
2-dehydro-3-deoxyphosphooctonate aldolase (Bordetella parapertussis 12822) | Protein Target - PubChem
Undecaprenyl-diphosphatase (Bordetella parapertussis 12822) | Protein Target - PubChem
Prevalence of Bordetella pertussis and Bordetella parapertussis infections in Tunisian hospitalized infants: results of a 4...
Biognost® Bordetella parapertussis IgM Kit* (30-206M) | Szabo-Scandic
ICD-10 kod A371 - Kikhosta orsakad av Bordetella parapertussis
Whooping cough due to Bordetella parapertussis w/o pneumonia ICD-10-CM Code- A3710 - Medical Billing Forum
Quidel Receives FDA Clearance for Solana® Bordetella Complete® Molecular Diagnostic Assay for the Detection of Pertussis,...
Immunization | Medscape
Microorganisms | Free Full-Text | COVID-19 Is a Multifaceted Challenging Pandemic Which Needs Urgent Public Health Interventions
2019-2020
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Outbreaks of Respiratory Illness Mistakenly Attributed to Pertussis --- New Hampshire, Massachusetts, and Tennessee, 2004-...
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Pertussis Treatment & Management: Approach Considerations, Pharmacologic Therapy, Immunization
While Media & Big Medicine Tell Us Vaccines Are Safe, A Plethora of Scientific Studies Prove Otherwise (March 3, 2015)
BacteriologyClongen Laboratories
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Belilovsky Pediatric Center » Articles
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Caroff M[Author] - Search Results - PubMed
Seasonal Bordetella pertussis pattern in the period from 2008 to 2018 in Germany | BMC Infectious Diseases | Full Text
What is parapertussis? - Whooping Cough Information
Bronchiseptica3
- Bordetella bronchiseptica", stain RB50, is a small (0.4 by 8.0 um), gram negative, rod shaped beta-proteobacteria belonging to the Bordetellae family. (kenyon.edu)
- B. bronchiseptica" is closely related to "Bordetella pertussis" and "Bordetella parapertussis", causing pertussis or whooping cough in humans [2]. (kenyon.edu)
- Bordetella bronchiseptica" can infect a wide range of hosts causing different diseases and is most commonly found in canines, pigs, and laboratory animals [2]. (kenyon.edu)
Holmesii2
- They are Bordetella pertussis, the commonest, Bordetella parapertussis, and the rarest which is Bordetella holmesii. (whoopingcough.net)
- Other Bordetella species, such as Bordetella parapertussis ( 3 ) and Bordetella holmesii ( 4 ), can cause diseases similar to pertussis, albeit usually with much less severe symptoms than typical whooping cough caused by B. pertussis . (frontiersin.org)
Cough17
- 1 year with and without pertussoid cough were investigated for the presence of B. pertussis/parapertussis using culture and real-time polymerase chain reaction (PCR). (pasteur.fr)
- Pertussis, or whooping cough, is a very contagious disease caused by the Bordetella pertussis bacteria, which attach to the cilia that line part of the upper respiratory tract, causing inflammation through the release of toxins, which cause airways to swell. (rapidmicromethods.com)
- Although whooping cough cases can be sporadic, outbreaks are often highly contagious, and we believe that this test can provide healthcare workers with the ability to quickly diagnose whooping cough and B. parapertussis. (rapidmicromethods.com)
- Bordetella parapertussis also has been associated with whooping cough in humans. (medscape.com)
- The most common single agent was B. pertussis, representing 56%(64/115), with a median cough period of 51 d, followed by M. pneumoniae 26%(30/115), 23 d, C. pneumoniae 17% (19/115), 26 d, and B. parapertussis 2% (2/115). (babydr.us)
- Spasmodic cough for 21 d or more (clinical WHO criteria for pertussis) was present in 82% (41/50) of infections with B. pertussis as single agent, 38% (17/45) with B. parapertussis, 38% (5/13) with C. pneumoniae, 26% (5/19) with M. pneumoniae and 30%(17/56) in cases where no aetiology was found. (babydr.us)
- Whooping cough, also known as pertussis, is a respiratory disease that is predominantly caused by the gram-negative bacterium Bordetella pertussis , which is found only in humans [ 1 ]. (biomedcentral.com)
- That is not a surprise, but what is surprising is that Germany and France are discovering that the predominant organism causing whooping cough is B. parapertussis. (whoopingcough.net)
- Clearly they will be negative for whooping cough if parapertussis is the cause as it does not produce this toxin, leading to a negative diagnosis when it is really positive. (whoopingcough.net)
- Pertussis or whooping cough, mainly caused by Bordetella pertussis , is a severe respiratory disease that can affect all age groups but is most severe and can be life-threatening in young children. (frontiersin.org)
- The main causative agent of whooping cough is Bordetella pertussis ( 2 ), a gram negative coccobacillus which is able to colonize the human upper respiratory tract by attaching to the ciliated cells. (frontiersin.org)
- Antigens of Bordetella pertussis that not only are completely ineffective at preventing infection with Bordetella parapertussis , a whooping cough bacterium similar to B. pertussis , but actually promote it by interfering with the body's natural infection clearance protocols. (naturalnews.com)
- W]e show that aP [whooping cough] vaccination impedes host immunity against B. parapertussis -measured as reduced lung inflammatory and neutrophil responses," wrote the authors. (naturalnews.com)
- In other words, children who are vaccinated for whooping cough actually suffer from decreased immunity and are more susceptible to B. parapertussis infection than their unvaccinated peers. (naturalnews.com)
- The pathogenic bacteria Bordetella pertussis and Bordetella parapertussis cause pertussis (whooping cough) and pertussis-like disease, respectively, both of which are characterized by paroxysmal coughing. (bvsalud.org)
- In contrast, the mechanism of cough induced by B. parapertussis, which produces Vag8 and lipopolysaccharide (LPS) containing lipid A, but not PTx, remained to be elucidated. (bvsalud.org)
- Here, we show that a toxin we named deacylating autotransporter toxin (DAT) of B. parapertussis inactivates heterotrimeric Gi GTPases through demyristoylation of their α subunits and contributes to cough production along with Vag8 and LPS. (bvsalud.org)
Bacteria2
- This antigen protects B. parapertussis against antibodies specific to B. pertussis, so the bacteria are free to colonize the host's lungs without being subject to attack by previous antibodies. (wikipedia.org)
- According to the CDC, B. parapertussis causes a pertussis-like illness that is generally milder than pertussis, likely because the bacteria do not produce pertussis toxin. (rapidmicromethods.com)
Chlamydia1
- Material collected during a prospective pertussis vaccine trial in 1992-95 was examined for Bordetella pertussis (culture and serology), Bordetella parapertussis (culture), Mycoplasma pneumoniae and Chlamydia pneumoniae (PCR). (babydr.us)
Infection7
- Immunity derived from B. pertussis does not protect against infection by B. parapertussis, however, because the O-antigen is found only on B. parapertussis. (wikipedia.org)
- Co-infection of B. pertussis and B. parapertussis can occur but is uncommon. (rapidmicromethods.com)
- 6] B. parapertussis is not easily distinguished from B. pertussis infection by symptoms, and unlike B. pertussis, usually it is not laboratory confirmed. (rapidmicromethods.com)
- Acellular pertussis vaccination facilitates Bordetella parapertussis infection in a rodent model of bordetellosis. (greatergoodmovie.org)
- Our data raise the possibility that widespread aP vaccination can create hosts more susceptible to B. parapertussis infection. (naturalnews.com)
- These results indicate that DAT plays a role in B. parapertussis infection in place of PTx. (bvsalud.org)
- Pertussis is a respiratory tract infection caused by the gram-negative coccobacillus Bordetella pertussis . (medscape.com)
Specimens2
- All except 1 NPAs were negative by conventional culture, whereas PCR gave positive signals for 126 specimens (21%): B. pertussis, B. parapertussis, and Bordetella spp. (pasteur.fr)
- Hassan, F., Hays, L., Bell, J., Selvarangan, R. Evaluation of 3 analyte-specific reagents for detection of Bordetella pertussis and Bordetella parapertussis in clinical specimens Diagnostic Microbiology and Infectious Disease 80, 181-184 (2014). (childrensmercy.org)
Infections1
- Specific diagnostic tools were applied for the first time in a Tunisian prospective study in order to get a first estimation of the prevalence of Bordetella pertussis/parapertussis infections and to evaluate their use to determine the epidemiologic characteristics of these infections in Tunisian infants. (pasteur.fr)
Bacterial1
- Vaccines of this type, prepared from suspensions of inactivated Bordetella pertussis bacterial cells, have been licensed for routine vaccination of infants since the mid-1940s. (cdc.gov)
Organism1
- The most common causative organism is Bordetella pertussis (see the image below), though Bordetella parapertussis also has been associated with this condition in humans. (medscape.com)
Pertussis toxin1
- The good news is that is considered less serious than B. pertussis possibly because it does not produce pertussis toxin which is just one of the toxins Bordetella can produce. (whoopingcough.net)
Vaccination1
- W]e conclude that aP vaccination interferes with the optimal clearance of B. parapertussis and enhances the performance of this pathogen. (naturalnews.com)
Avium2
- Description: Bordetella Avium Arginine--tRNA ligase, recombinant protein. (gemini-genomics.com)
- Bordetella avium sp. (microbiologyresearch.org)
Bacterium2
- Bordetella parapertussis is a small Gram-negative bacterium of the genus Bordetella that is adapted to colonise the mammalian respiratory tract. (wikipedia.org)
- A photomicrograph of the bacterium Bordetella pertussis, using Gram stain technique. (medscape.com)
Immunity2
- These findings suggest B. parapertussis evolved in a host population that had already developed immunity to B. pertussis, where being able to evade B. pertussis immunity was an advantage. (wikipedia.org)
- This increase has been attributed to increased circulation of Bordetella pertussis , waning vaccine-induced immunity among adults and adolescents, heightened awareness of pertussis among health-care providers, increased public health reporting, and increased use of polymerase chain reaction (PCR) testing for diagnosis ( 1 ). (cdc.gov)
Genomes1
- The assay targets the IS481 and IS1001 sequence of the Bordetella pertussis and Bordetella pertussis genomes, respectively. (rapidmicromethods.com)
Clinical2
- Genetic heterogeneity of ribosomal internal transcribed spacer in clinical samples of Leishmania donovani spotted on We report a pseudo-outbreak of Bordetella par- filter paper as revealed by single-strand conformation apertussis in the Department of Pediatrics in polymorphisms and sequencing. (cdc.gov)
- B parapertussis is less common than B pertussis and produces a clinical illness that is similar to, but milder than, that produced by B pertussis . (medscape.com)
Detection2
- When possible, patients' household contacts provided nasopharyngeal aspirates (NPAs) for RT-PCR detection of B. pertussis/parapertussis or single-serum samples for anti-PT IgG quantification. (pasteur.fr)
- Evaluation of 3 analyte-specific reagents for detection of Bordetella " by Ferdaus Hassan, Lindsay Hays et al. (childrensmercy.org)
Species1
- CDC is actively researching new laboratory methods to better identify and characterize other Bordetella and Corynebacterium species. (cdc.gov)
Acellular1
- Concerns about the safety of whole-cell pertussis vaccines prompted development of acellular vaccines that are less likely to provoke adverse events because they contain purified antigenic components of Bordetella pertussis. (cdc.gov)
Illness caused1
- For these reasons, the epidemiology of illness caused by B. parapertussis is poorly recognized. (rapidmicromethods.com)
Humans1
- Humans are the sole reservoir for B pertussis and B parapertussis . (medscape.com)
Poorly1
- Immunisation against B.pertussis, which is standard is thought to be ineffective or poorly effective against B. parapertussis. (whoopingcough.net)
Optimal1
- Optimal growth for all Bordetella spp. (kenyon.edu)
Symptoms1
- Pertussis caused by B. parapertussis manifests with similar symptoms to B. pertussis-derived disease, but in general tends to be less severe. (wikipedia.org)
Severe1
- Simptome foarte asemănătoare tusei convulsive pot fi prezente și în cazul infecțiilor cauzate de specii înrudite de bacterii, precum Bordetella parapertussis, acestea fiind de obicei mai puțin severe 37 . (synevo.ro)
Molecular3
- Molecular evolution and host adaptation of Bordetella spp. (wikipedia.org)
- The Solana Bordetella Complete Assay leverages the Helicase-Dependent Amplification (HDA) technology that is resident in Quidel's AmpliVue® molecular product line to generate a fast and accurate test result on the Solana molecular diagnostic instrument. (rapidmicromethods.com)
- We are pleased to receive 510(k) clearance for our Solana Bordetella Complete Assay, as this test rounds out our Solana molecular test offering in the respiratory category," said Douglas Bryant, president and chief executive officer of Quidel Corporation. (rapidmicromethods.com)
Positive3
- An increase in positive Bordetella parapertussis tests repeat proteins by Leishmania amastigotes. (cdc.gov)
- PCR-positive case-patients had pertussis-like of Fisheries and Livestock, Department of Veterinary Services, complaints, and we confirmed B. parapertussis in the Central Veterinary Research Institute, PO Box 33980, Lusaka, patients or their siblings. (cdc.gov)
- When paired with Quidel's Virena ecosystem, clinicians will be able to see real-time positive cases at the local level, giving them further insights into disease prevalence for both parapertussis and pertussis. (rapidmicromethods.com)
Cases1
- The simultaneous presence of B. pertussis and B. parapertussis was noted in 8% of the cases. (pasteur.fr)
Quickly1
- It parapertussis really gets hold we will quickly learn an awful lot more. (whoopingcough.net)