Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Ki-67 Antigen: A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Breast Neoplasms: Tumors or cancer of the human BREAST.Receptors, Progesterone: Specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. The cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. There are two kinds of progesterone receptors, A and B. Both are induced by estrogen and have short half-lives.Sex Factors: Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.Environment: The external elements and conditions which surround, influence, and affect the life and development of an organism or population.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Socioeconomic Factors: Social and economic factors that characterize the individual or group within the social structure.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Seasons: Divisions of the year according to some regularly recurrent phenomena usually astronomical or climatic. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Receptors, Estrogen: Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.United StatesCohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Regression Analysis: Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Logistic Models: Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.European Continental Ancestry Group: Individuals whose ancestral origins are in the continent of Europe.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Cross-Sectional Studies: Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Biological Factors: Endogenously-synthesized compounds that influence biological processes not otherwise classified under ENZYMES; HORMONES or HORMONE ANTAGONISTS.Prevalence: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.Biological Products: Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.Biological Assay: A method of measuring the effects of a biologically active substance using an intermediate in vivo or in vitro tissue or cell model under controlled conditions. It includes virulence studies in animal fetuses in utero, mouse convulsion bioassay of insulin, quantitation of tumor-initiator systems in mouse skin, calculation of potentiating effects of a hormonal factor in an isolated strip of contracting stomach muscle, etc.Biological Therapy: Treatment of diseases with biological materials or biological response modifiers, such as the use of GENES; CELLS; TISSUES; organs; SERUM; VACCINES; and humoral agents.Biological Warfare: Warfare involving the use of living organisms or their products as disease etiologic agents against people, animals, or plants.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Biological Processes: Biological activities and function of the whole organism in human, animal, microorgansims, and plants, and of the biosphere.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Computational Biology: A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Pest Control, Biological: Use of naturally-occuring or genetically-engineered organisms to reduce or eliminate populations of pests.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Computer Simulation: Computer-based representation of physical systems and phenomena such as chemical processes.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Biological Evolution: The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Systems Biology: Comprehensive, methodical analysis of complex biological systems by monitoring responses to perturbations of biological processes. Large scale, computerized collection and analysis of the data are used to develop and test models of biological systems.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Biological Clocks: The physiological mechanisms that govern the rhythmic occurrence of certain biochemical, physiological, and behavioral phenomena.Gene Regulatory Networks: Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations.Biology: One of the BIOLOGICAL SCIENCE DISCIPLINES concerned with the origin, structure, development, growth, function, genetics, and reproduction of animals, plants, and microorganisms.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Relative Biological Effectiveness: The ratio of radiation dosages required to produce identical change based on a formula comparing other types of radiation with that of gamma or roentgen rays.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Cell Line, Tumor: A cell line derived from cultured tumor cells.Kinetics: The rate dynamics in chemical or physical systems.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Cluster Analysis: A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.Mass Spectrometry: An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.Protein Interaction Mapping: Methods for determining interaction between PROTEINS.Genomics: The systematic study of the complete DNA sequences (GENOME) of organisms.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Biological Transport: The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Models, Genetic: Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.Protein Structure, Tertiary: The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Biological Control Agents: Organisms, biological agents, or biologically-derived agents used strategically for their positive or adverse effect on the physiology and/or reproductive health of other organisms.Proteomics: The systematic study of the complete complement of proteins (PROTEOME) of organisms.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Proteome: The protein complement of an organism coded for by its genome.Protein Conformation: The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).Information Storage and Retrieval: Organized activities related to the storage, location, search, and retrieval of information.Databases, Factual: Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.Metabolic Networks and Pathways: Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Bacteria: One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Models, Statistical: Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Fermentation: Anaerobic degradation of GLUCOSE or other organic nutrients to gain energy in the form of ATP. End products vary depending on organisms, substrates, and enzymatic pathways. Common fermentation products include ETHANOL and LACTIC ACID.Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.Biological Warfare Agents: Living organisms or their toxic products that are used to cause disease or death of humans during WARFARE.Drug Design: The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Biological Psychiatry: An interdisciplinary science concerned with studies of the biological bases of behavior - biochemical, genetic, physiological, and neurological - and applying these to the understanding and treatment of mental illness.Computer Graphics: The process of pictorial communication, between human and computers, in which the computer input and output have the form of charts, drawings, or other appropriate pictorial representation.Models, Theoretical: Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.Toxins, Biological: Specific, characterizable, poisonous chemicals, often PROTEINS, with specific biological properties, including immunogenicity, produced by microbes, higher plants (PLANTS, TOXIC), or ANIMALS.Biological Phenomena: Biological processes, properties, and characteristics of the whole organism in human, animal, microorganisms, and plants, and of the biosphere.Databases, Protein: Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Biological Specimen Banks: Facilities that collect, store, and distribute tissues, e.g., cell lines, microorganisms, blood, sperm, milk, breast tissue, for use by others. Other uses may include transplantation and comparison of diseased tissues in the identification of cancer.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Ligands: A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)Models, Chemical: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Nanotechnology: The development and use of techniques to study physical phenomena and construct structures in the nanoscale size range or smaller.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Sequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.Cell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.Molecular Conformation: The characteristic three-dimensional shape of a molecule.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Temperature: The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Environmental Monitoring: The monitoring of the level of toxins, chemical pollutants, microbial contaminants, or other harmful substances in the environment (soil, air, and water), workplace, or in the bodies of people and animals present in that environment.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Cell Membrane: The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Evolution, Molecular: The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.Protein Interaction Maps: Graphs representing sets of measurable, non-covalent physical contacts with specific PROTEINS in living organisms or in cells.Transcriptome: The pattern of GENE EXPRESSION at the level of genetic transcription in a specific organism or under specific circumstances in specific cells.Biological Dressings: Human or animal tissue used as temporary wound coverings.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).Antirheumatic Agents: Drugs that are used to treat RHEUMATOID ARTHRITIS.MicroRNAs: Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.Recombinant Fusion Proteins: Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.Phosphorylation: The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.Genetic Variation: Genotypic differences observed among individuals in a population.Biotechnology: Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Genome: The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.Cricetinae: A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.Cell Physiological Phenomena: Cellular processes, properties, and characteristics.Systems Integration: The procedures involved in combining separately developed modules, components, or subsystems so that they work together as a complete system. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Ecosystem: A functional system which includes the organisms of a natural community together with their environment. (McGraw Hill Dictionary of Scientific and Technical Terms, 4th ed)Bacterial Proteins: Proteins found in any species of bacterium.Physicochemical Phenomena: The physical phenomena describing the structure and properties of atoms and molecules, and their reaction and interaction processes.Cells: The fundamental, structural, and functional units or subunits of living organisms. They are composed of CYTOPLASM containing various ORGANELLES and a CELL MEMBRANE boundary.Biological Availability: The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.Surface Properties: Characteristics or attributes of the outer boundaries of objects, including molecules.Fungi: A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies.Saccharomyces cerevisiae: A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Molecular Sequence Annotation: The addition of descriptive information about the function or structure of a molecular sequence to its MOLECULAR SEQUENCE DATA record.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Biocompatible Materials: Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.Crystallography, X-Ray: The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Synthetic Biology: A field of biological research combining engineering in the formulation, design, and building (synthesis) of novel biological structures, functions, and systems.Chemistry, Physical: The study of CHEMICAL PHENOMENA and processes in terms of the underlying PHYSICAL PHENOMENA and processes.Nanostructures: Materials which have structured components with at least one dimension in the range of 1 to 100 nanometers. These include NANOCOMPOSITES; NANOPARTICLES; NANOTUBES; and NANOWIRES.Gene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.Water: A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)DNA Primers: Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.Fibroblasts: Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.Microscopy, Fluorescence: Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.Protein Processing, Post-Translational: Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.Chromatography, Liquid: Chromatographic techniques in which the mobile phase is a liquid.DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Biosensing Techniques: Any of a variety of procedures which use biomolecular probes to measure the presence or concentration of biological molecules, biological structures, microorganisms, etc., by translating a biochemical interaction at the probe surface into a quantifiable physical signal.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Streptomyces: A genus of bacteria that form a nonfragmented aerial mycelium. Many species have been identified with some being pathogenic. This genus is responsible for producing a majority of the ANTI-BACTERIAL AGENTS of practical value.Sequence Analysis, Protein: A process that includes the determination of AMINO ACID SEQUENCE of a protein (or peptide, oligopeptide or peptide fragment) and the information analysis of the sequence.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)DNA, Complementary: Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.Artificial Intelligence: Theory and development of COMPUTER SYSTEMS which perform tasks that normally require human intelligence. Such tasks may include speech recognition, LEARNING; VISUAL PERCEPTION; MATHEMATICAL COMPUTING; reasoning, PROBLEM SOLVING, DECISION-MAKING, and translation of language.Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.Body Fluids: Liquid components of living organisms.Thermodynamics: A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.Biomimetics: An interdisciplinary field in materials science, ENGINEERING, and BIOLOGY, studying the use of biological principles for synthesis or fabrication of BIOMIMETIC MATERIALS.Data Mining: Use of sophisticated analysis tools to sort through, organize, examine, and combine large sets of information.Fluorescent Dyes: Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.Pattern Recognition, Automated: In INFORMATION RETRIEVAL, machine-sensing or identification of visible patterns (shapes, forms, and configurations). (Harrod's Librarians' Glossary, 7th ed)Plants: Multicellular, eukaryotic life forms of kingdom Plantae (sensu lato), comprising the VIRIDIPLANTAE; RHODOPHYTA; and GLAUCOPHYTA; all of which acquired chloroplasts by direct endosymbiosis of CYANOBACTERIA. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (MERISTEMS); cellulose within cells providing rigidity; the absence of organs of locomotion; absence of nervous and sensory systems; and an alternation of haploid and diploid generations.Protein Structure, Secondary: The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.RNA: A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)HeLa Cells: The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.

*  The Expression Level of HJURP Has an Independent Prognostic Impact and Predicts the Sensitivity to R
... adiotherapy in Breast Cancer. OpenBU The Expression Level of HJURP Has an Independent Prognostic Impact and Predicts the Sensitivity to Radiotherapy in Breast Cancer. OpenBU → School of Medicine → Basic Science → Department of Pathology and Laboratory Medicine → MED: Pathology and Laboratory Medicine Papers → View Item. The Expression Level of HJURP Has an Independent Prognostic Impact and Predicts the Sensitivity to Radiotherapy in Breast Cancer. Hu, Zhi ; Huang, Ge ; Sadanandam, Anguraj ; Gu, Shenda ; Lenburg, Marc E ; Pai, Melody ; Bayani, Nora ; Blakely, Eleanor A ; Gray, Joe W ; Mao, Jian-Hua. Citation: Hu, Zhi, Ge Huang, Anguraj Sadanandam, Shenda Gu, Marc E Lenburg, Melody Pai, Nora Bayani, Eleanor A Blakely, Joe W Gray, Jian-Hua Mao. "The expression level of HJURP has an independent prognostic impact and predicts the sensitivity to radiotherapy in breast cancer" Breast Cancer Research: BCR 12 2 :R18. Higher HJURP mRNA levels significantly decreased disease-free and overall survival. In a multivari...
https://open.bu.edu/handle/2144/3337
*  Study: Brain scans can improve long-term prognosis predictions - GoErie.com - Erie, PA
... . Toggle navigation. eEdition. Subscribe. Customer Service. Member Center. Log In. 65 65. Local. Local Home. Latest News. Obituaries. Weather. Erie Times-News. Education. Politics. Crime. Vital Statistics. Crawford County. Traffic & Road Work. Sports. Sports Home. High Schools. Varsity Prime. Colleges. Otters. BayHawks. SeaWolves. Explosion. Outdoors. Columns & Blogs. Entertainment. Entertainment Home. CelebrateErie. Events Calendar. Nightlife & Bar Specials. Bars & Restaurants. Movies. TV. Music. Theater & Arts. Contests & Games. Comics. Street View. Columns & Blogs. Erie Living. Erie Living Home. Food, Beer & Wine. Recipes. Home & Garden. Health. History. Celebrations. Columns, Blogs & Newsletters. Her Times. House to Home. Lake Erie LifeStyle. Erie Moms. Presque Isle. Business. Business Home. Biz Buzz Blog. Commitment to Erie Business Awards. Local Business Directory. Opinion. Opinion Home. Letters to the Editor. Good Morning. Our View. Local Columnists. Other Columns. Classifieds. Classifieds Home. N...
http://goerie.com/article/20140421/LIFESTYLES07/304219984/In-Brief:-Free-drug-samples-costly-to-patients-study-says
*  Prognosis factors in probands with an FBN1 mutation diagnosed before the age of 1 year
... Chantal Stheneur, Laurence Faivre, Gwenaelle Collod-Beroud, Elodie Gautier, Christine Binquet, Claira-e Bonithon-Kopp, Mireille Claustres, Anne H Child, Eloisa Arbustini. Pediatr Res 69: 265-270, 2011 }, author = {Stheneur, Chantal and Faivre, Laurence and Collod-Beroud, Gwenaelle and Gautier, Elodie and Binquet, Christine and Bonithon-Kopp, Claira-e and Claustres, Mireille and Child, Anne H and Arbustini, Eloisa and Ades, Lesley C and Francke, Uta and Mayer, Karin and Arslan-Kirchner, Mine and De Paepe, Anne and Chevallier, Bertrand and Bonnet, Damien and Jondeau, Guillaume and Boileau, Catherine}, issn = {0031-3998}, journal = {PEDIATRIC RESEARCH}, keyword = {GENOTYPE-PHENOTYPE CORRELATIONS,CLINICAL PHENOTYPES,NEONATAL MARFAN-SYNDROME,SERIES,FIBRILLIN-1,TGFBR2,DATABASE,GENE}, language = {eng}, number = {3}, pages = {265--270}, title = {Prognosis factors in probands with an FBN1 mutation diagnosed before the age of 1 year}, volume = {69}, year = {2011}, }. Stheneur, Chantal, Laurence Faivre, Gwenaelle C...
https://biblio.ugent.be/publication/1199109
*  Arginine and Nitric Oxide (NO) Early Prognostic Markers for Non-union Development - Full Text View -
Arginine and Nitric Oxide NO Early Prognostic Markers for Non-union Development - Full Text View - ClinicalTrials.gov. Verified April 2010 by Maastricht University Medical Center. Recruitment status was Recruiting Sponsor: Maastricht University Medical Center Information provided by: Maastricht University Medical Center. Objective: Primary objective is to study the arginine-NO metabolism during fracture healing and dysfunctional fracture healing. Secondary objective: to investigate if differences or decreased arginine and NO concentrations in bone healing form a prognostic marker for non-union development Hypothesis: Early detection of disturbances in the Arginine and nitric oxide metabolism during fracture healing are a good prognostic marker for non-union development. Main study parameters/endpoints: Primary endpoints are arginine and Nitric Oxide levels in the plasma during normal and dysfunctional fracture healing the bone in patients with and without non-union Secondary endpoints are levels of Nitric Oxi...
https://clinicaltrials.gov/ct2/show/NCT01070576
*  The impact of novel exercise criteria and indices for the diagnostic and prognostic ability of exerc
... ise testing. BioMedSearch. Home. Advanced Search. Tools. Search Tutorial. Login. Create Free Account. Document Detail. The impact of novel exercise criteria and indices for the diagnostic and prognostic ability of exercise testing. MedLine Citation:. PMID: 20303605 Owner: NLM Status: MEDLINE. Abstract/OtherAbstract:. Exercise testing ET stands as one of the most easy, affordable, cost effective, non invasive methods for diagnosing coronary heart disease. Its sensitivity, specificity and prognostic value, especially in the prime era of its implementation in the cardiac diagnostic procedure, is relatively limited. Novel exercise criteria and indices based either on ST segment changes or ST segment independent parameters, such as "Athens QRS score", have greatly improved the diagnostic ability and accuracy of ET. Complex ECG-derived indices linked to ST changes along with the use of right-sided precordial leads have also enhanced the diagnostic accuracy of ET with respect to the extent of ischemic heart dise...
http://biomedsearch.com/nih/impact-novel-exercise-criteria-indices/20303605.html
*  Cancer Prognostic Resources
... a catalog of interactive cancer prognostic tools need help tutorial faq glossary contact us home resources submit a tool about us view all tools compare tools by cancer site search tools user name password summary of all tools a list of all cancer prognostic tools is provided indicating the number of included calculators and cancer sites tool name number of calculators cancer sites adjuvant online description website american joint committee on cancer description website cancer survival query system description website cancermath description website capra description website ebrt description website finprog description website glioblastoma gbm description website han tables description website ibtr description website knight cancer institute description website lerner research institute description website ...
http://cancercalculators.org/tools.aspx
*  Free circulating mRNA in plasma from breast cancer patients and clinical outcome - ResearchGate
... Article Free circulating mRNA in plasma from breast cancer patients and clinical outcome. Impact Factor: 5.62. ABSTRACT We studied by real-time PCR cyclin D1 and thymidylate synthase TS mRNA in plasma as possible markers of clinical outcome in breast cancer. Presence of both markers was associated with non-response to treatment after relapse. Cyclin D1 mRNA in plasma could identify patients with poor overall survival in good-prognosis groups and patients non-responsive to tamoxifen. Furthermore, levels of CCND1 mRNA, which encodes the cell-cycle protein cyclin D1, identified patients with breast cancer with poor overall survival in good-prognosis groups and patients who were non-responsive to tamoxifen. Circulating nucleic acids as biomarkers in breast cancer. As circulating cell-free tumor nucleic acids may reflect the characteristics of the primary tumor and even of micrometastatic cells, they may be excellent blood biomarkers for screening breast cancer. This review evaluates the recent data on the po...
http://researchgate.net/publication/5570834_Free_circulating_mRNA_in_plasma_from_breast_cancer_patients_and_clinical_outcome
*  Protein Expression Profiling Identifies Subclasses of Breast Cancer and Predicts Prognosis -- Ja
P = 0.008; Fisher's exact test and ERBB2-positive P = 0.001; Fisher's exact test than ER-positive A1 samples. Classification of 552 breast cancer samples based on the expression of the 21-protein discriminator set identified by supervised analysis. The same threshold for the metastatic score identified two classes that strongly correlated with survival with 21 metastatic relapses out of the 61 patients 34% in the poor-prognosis class and 13 11% of 123 patients in the good-prognosis class OR, 4.4; 95% CI, 1.9-10.5; P = 0.0001, Fisher's exact test; Fig. The difference of survival is significant between the good-prognosis class and the poor-prognosis class for the node-negative patients, as well as for the node-positive patients. In contrast, survival is not significantly different between the node-positive patients from the good-prognosis class and the node-negative patients from the poor-prognosis class. In the good-prognosis class, 27 of 161 patients experienced metastatic relapse as compared with 44 of 94 pa...
http://hwmaint.cancerres.aacrjournals.org/cgi/content/full/65/3/767
*  PLOS ONE: Decreased FOXF2 mRNA Expression Indicates Early-Onset Metastasis and Poor Prognosis for Br
... east Cancer Patients with Histological Grade II Tumor. Article-Level Metrics. View. Sum of PLOS and PubMed Central page views and downloads. Open Access Peer-reviewed Research Article. Decreased FOXF2 mRNA Expression Indicates Early-Onset Metastasis and Poor Prognosis for Breast Cancer Patients with Histological Grade II Tumor. Published: April 19, 2013 DOI: 10.1371/journal.pone.0061591. Article. Taken together, we conclude that decreased FOXF2 expression indicates the early-onset metastasis and poor prognosis for patients with histological grade II and triple-negative breast cancer. For patients with histologic grade II tumors n = 226, FOXF2 low patients had significantly shorter 3-year P = 0.010, 5-year P = 0.038, and overall DFS P = 0.032 than FOXF2 high patients. For patients with triple-negative breast cancer subtype n = 39, FOXF2 low patients had poorer 3-year DFS P = 0.013, 5-year DFS P = 0.002, and overall DFS P = 0.002 than FOXF2 high patients, whereas there was no significant correlation between...
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061591
*  Protein expression based multimarker analysis of breast cancer samples (PDF Download Available)
Protein expression based multimarker analysis of breast cancer samples PDF Download Available. For full functionality of ResearchGate it is necessary to enable JavaScript. Here are the instructions how to enable JavaScript in your web browser. Article Protein expression based multimarker analysis of breast cancer samples. Angela Presson. Angela Presson University of Utah Message author. Remove suggestion. Nam K Yoon. Nam K Yoon. Remove suggestion. Lora Bagryanova. Lora Bagryanova. Remove suggestion. Vei Mah. Vei Mah. Remove suggestion. Mohammad Alavi. Mohammad Alavi. Remove suggestion. Erin L Maresh. Erin L Maresh. Remove suggestion. Department of Biostatistics, UCLA, Los Angeles, CA 90095, USA. BMC Cancer. Impact Factor: 3.36. 06/2011; 11 1 :230. DOI: 10.1186/1471-2407-11-230 Source: PubMed. ABSTRACT Tissue microarray TMA data are commonly used to validate the prognostic accuracy of tumor markers. For example, breast cancer TMA data have led to the identification of several promising prognostic markers of su...
http://researchgate.net/publication/51200387_Protein_expression_based_multimarker_analysis_of_breast_cancer_samples
*  Depressed cancer patients 'ignored' (From Echo)
Depressed cancer patients 'ignored' From Echo. By staying on our website you agree to our use of cookies. Forgotten password / Forgotten email. Health News. National News. Depressed cancer patients 'ignored'. Cancer patients are more likely to suffer from major depression, figures show. The outcome with usual care is poor. "We've described a new approach to managing depressed cancer patients that is based on the short-comings of usual care and integrated with cancer care that really has quite spectacular effects in the good prognosis patients and also has efficacy in the poor prognosis patients.". Those with lung cancer had the highest prevalence of major depression 13.1% followed by patients with gynaecological cancers 10.9% and breast cancer 9.3%. At the time of screening, 73% of 1,538 patients diagnosed with depression for whom information about treatment was available were not receiving "potentially effective" therapy for their mental state. Patients randomly recruited to the programme had their progress ...
http://echo-news.co.uk/news/national/11436329.Depressed_cancer_patients__ignored_/?ref=var_0
*  Depressed cancer patients 'ignored' (From Haringey Independent)
Depressed cancer patients 'ignored' From Haringey Independent. Forgotten password / Forgotten email. Health News. National News. Depressed cancer patients 'ignored'. Cancer patients are more likely to suffer from major depression, figures show. The outcome with usual care is poor. "We've described a new approach to managing depressed cancer patients that is based on the short-comings of usual care and integrated with cancer care that really has quite spectacular effects in the good prognosis patients and also has efficacy in the poor prognosis patients.". What this programme does is get people back engaged with life and feeling more in control of their lives again. Those with lung cancer had the highest prevalence of major depression 13.1% followed by patients with gynaecological cancers 10.9% and breast cancer 9.3%. At the time of screening, 73% of 1,538 patients diagnosed with depression for whom information about treatment was available were not receiving "potentially effective" therapy for their mental st...
http://haringeyindependent.co.uk/news/national/11436329.Depressed_cancer_patients__ignored_/?ref=var_0
*  Can I Survive Acute Myeloid Leukemia (AML)? What Is My Prognosis?
Can I Survive Acute Myeloid Leukemia AML. Cancer. Health Library Explorer. Cancer. Conditions & Treatments. Adult Health Library. Diabetes. Men's Health. Mental Health Disorders. Oral Health. Women's Health. Pediatric Health Library. Diabetes Endocrinology. Test and Procedures. Children Ages 0-2. Children Ages 2-18. The chance that you will recover or have a recurrence depends on many factors, including the type of leukemia, how well it responds to treatment, and your age and general health. Before discussing your prognosis with you, your doctor will consider all the things that could affect your disease and treatment. To do that, the doctor will look at what researchers have found out over many years about thousands of people with leukemia. If your cancer is likely to respond well to treatment, your doctor will say you have a favorable prognosis. Some people find it easier to cope when they know their prognosis and the statistics for how well a treatment might work. Survival rates show the percentage of peop...
http://healthlibrary.nebraskamed.com/conditions/cancer/34,BAMLD5
*  Developing Predictive Indicators of Cell Maturation as Measures of Cell Therapy Product Efficacy and
... Safety. FDA U.S. Follow FDA. Vaccines, Blood & Biologics. Vaccines, Blood & Biologics. Vaccines, Blood & Biologics. Developing Predictive Indicators of Cell Maturation as Measures of Cell Therapy Product Efficacy and Safety Share. Both the cells and their host environment carry out this communication by releasing signaling molecules called growth factors. To ensure that cell and tissue therapy products manufactured outside an organism will work effectively after they are administered to a patient, we are trying to de-code the complex communications used by cells during maturation. This research program uses a simple organism as a model to study communication among cells. Promising candidates can be tested in human cells or in mouse models to establish whether the candidate proteins will serve as markers whose activity can help us to predict how the cells and tissues will behave in a patient. Developing markers that help us to predict cell fate, cell behavior, and cell survival is critical to our role in ...
http://fda.gov/BiologicsBloodVaccines/ScienceResearch/BiologicsResearchAreas/ucm127186.htm
*  Tallest Man Surgery at UVA Deemed a Success | Community Idea Stations
tallest man surgery at uva deemed a success community idea stations skip to main content join us on donate now home watch listen learn support contact about menu home watch listen learn support contact about stay search stay donate you are here home tallest man surgery at uva deemed a success august charles fishburne google plus one facebook like tweet widget tallest man surgery at uva deemed a success fishburne tallestman mp the world s tallest man has been given a good prognosis following surgery yesterday at the uva medical center for a rare condition that causes uncontrolled growth charles fishburne has a follow up science matters report view the discussion thread thanks to our sponsors sign up for newsletters the community idea stations shop wcve schedule promote your business media sponsorship contacts directions volunteer pressroom independent producers public notices files privacy policy employment television schedules wcve video productions facility rental...
http://ideastations.org/radio/news/tallest-man-surgery-uva-deemed-success?quicktabs_radiostorytabs=transcript
*  Prognosis
... please note your web browser does not have javascript enabled unless you enable javascript your ability to navigate and access the features of this website will be limited glossary prognosis prediction about the course or outcome of a disease or illness the likelihood of recovery from a disease or illness by american association for clinical chemistry...
https://labtestsonline.org/glossary/prognosis/
*  Prognosis: VT vs AP
prognosis vt vs ap september prognosis vt vs ap doug bowman hokiehaven com who has the advantage at each position doug bowman breaks down each side to see how logan thomas the hokies might fare today against austin peay more to continue reading this article you must be a member sign up now already a member click here to sign in...
https://mississippistate.rivals.com/barrier_noentry.asp?script=/content.asp&cid=1406414
*  Prognosis: Hokies vs Bearcats
prognosis hokies vs bearcats september prognosis hokies vs bearcats doug bowman hokiehaven com who has the advantage at each position doug bowman breaks down each side to see how punt returner safety kyshoen jarrett the hokies might fare today against cincinnati more to continue reading this article you must be a member sign up now already a member click here to sign in...
https://nebraska.rivals.com/barrier_noentry.asp?script=/content.asp&cid=1415547
*  ERI's poor prognosis - The Scotsman
... ....
http://scotsman.com/news/eri-s-poor-prognosis-1-901678
*  BLN: CNN tries to kill itself! The ER prognosis is grim.
bln cnn tries to kill itself the er prognosis is grim...
http://biglicknews.blogspot.com/2009/11/cnn-tries-to-kill-itself-er-prognosis.html
*  .. prognostic factor
prognostic factor prog nos tik fak ter a situation or condition or a characteristic of a patient that can be used to estimate the chance of recovery from a disease or the chance of the disease recurring coming back...
http://uchospitals.edu/online-library/content=GLOSCDR44246
*  Comments on Prognosis negative
Miami Herald http://miamiherald.typepad.com/gator clause/ 2013-11-19T22:33:58Z TypePad...
http://miamiherald.typepad.com/gator_clause/2013/11/prognosis-negative/comments/atom.xml
*  Nonlinear system
In mathematics, a 'nonlinear system of equations' is a set of simultaneous equation s in which the unknown s or the unknown functions in the case of differential equation s appear as variables of a polynomial of degree higher than one or in the argument of a function which is not a polynomial of degree one. In other words, in a nonlinear system of equations, the equation s to be solved cannot be written as a linear combination of the unknown variables or functions that appear in them. Definition Nonlinear algebraic equations Nonlinear recurrence relations Nonlinear differential equations Ordinary differential equations. Partial differential equations. Nonlinear algebraic equations. Systems of polynomial equations. Nevertheless, in the case of the systems with a finite number of complex solutions, these systems of polynomial equations are now well understood and efficient methods exist for solving them. Nonlinear differential equations. A system of differential equation s is said to be nonlinear if it is not a...
https://en.wikipedia.org/wiki/Nonlinear_system
*  Institute for Mathematics and its Applications (IMA) - Tomography through the Transport Equation
institute for mathematics and its applications ima tomography through the transport equation by d s anikonov acad sci vladivostok russia main navigation main content go to the u of m home page onestop myu search u of m web sites college of science and engineering home programs activities annual thematic program programs activities annual thematic program postdoctoral fellowships hot topics and special abel conferences public lectures new directions pi programs industrial programs seminars be an organizer annual hot topics pi summer pi conference applying to participate talk abstract tomography through the transport equation d s anikonov acad sci vladivostok russia the transport equation is considered as a mathematical model of passage of the radiation through a medium the report deals with the inverse problems of the transport equation these problems consist in determination of the coefficients of the transport equation or their partial characterization provided the intensity of the radiation on the boundary ...
http://ima.umn.edu/hpc/wkshp_abstracts/anikonov1.html
*  Benjamin Gompertz
... {{Infobox scientist name = Benjamin Gompertz image = gompertz.png image size = 200px caption = |birth date = |birth place = London, England |death date = 'Benjamin Gompertz' 5 March 1779 – 14 July 1865 was a British self-educated mathematician and actuary, who became a Fellow of the Royal Society. Gompertz is now best known for his Gompertz law of mortality, a demographic model published in 1825. Life Works Family See also References Notes External links. Of the German Jewish family of Gompertz of Emmerich, he was born in London, where his father and grandfather had been successful diamond merchants. 1 In line with his father's wishes, he entered the London Stock Exchange. He became a member of the Mathematical Society of Spitalfields, and served as its president when it was merged with the Astronomical Society of London. In 1819 he was elected a F.R.S., and in 1832 became a member of the council. The Astronomical Society was founded in 1820, and he was elected a member of the council in 1821. On the dea...
https://en.wikipedia.org/wiki/Benjamin_Gompertz
*  Numerical Methods for Partial Differential Equations - Wiley Online Library
... Skip to Main Content. Log in / Register. Log In. Password. Forgotten Password. Register. Institutional Login. Mathematics. Differential Equations. Numerical Methods for Partial Differential Equations. JOURNAL TOOLS. Get New Content Alerts. Get RSS feed. JOURNAL MENU. Journal Home. FIND ISSUES. Current Issue. All Issues. FIND ARTICLES. OnlineOpen. Author Guidelines. Submit an Article. ABOUT THIS JOURNAL. Permissions. Contact. SPECIAL FEATURES. Wiley Job Network. Jobs. Numerical Methods for Partial Differential Equations. Wiley Periodicals, Inc. ISI Journal Citation Reports Ranking: 2014: 121/255 Mathematics Applied. Online ISSN: 1098-2426. Associated Title s : Numerical Linear Algebra with Applications. Recently Published Issues. Current Issue: November 2015. Volume 31, Issue 6. September 2015. Volume 31, Issue 5. Volume 31, Issue 4. Volume 31, Issue 3. Volume 31, Issue 2. Special Issue: Third Special Issue on The Mathemat... Author Guidelines. Recently Published Articles. Two unconditionally stable and c...
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1098-2426
*  Gompertz–Makeham law of mortality
... parameters = \alpha > 0 real \beta > 0 real \lambda > 0 real. pdf = \alpha e {\beta x} + \lambda \cdot \exp -\lambda x-\frac{\alpha}{\beta} e {\beta x}-1. cdf = 1-\exp -\lambda x-\frac{\alpha}{\beta} e {\beta x}-1. The 'Gompertz–Makeham law' states that the human death rate is the sum of an age-independent component the Makeham term, named after William Makeham. and an age-dependent component the Gompertz function, named after Benjamin Gompertz,. The Gompertz–Makeham law of mortality describes the age dynamics of human mortality rather accurately in the age window from about 30 to 80 years of age. At more advanced ages, some studies have found that death rates increase more slowly – a phenomenon known as the late-life mortality deceleration – but more recent studies disagree. The decline in the human mortality rate before the 1950s was mostly due to a decrease in the age-independent Makeham mortality component, while the age-dependent Gompertz mortality component was surprisingly stable. 2011 Ageing and ...
https://en.wikipedia.org/wiki/Gompertz–Makeham_law_of_mortality
*  Matrix model
... mathematics and physics in theoretical physics a matrix model is a system usually a quantum mechanical system with matrix valued physical quantities see for example lax pair the old matrix models are relevant for string theory in two spacetime dimensions the new matrix model is a synonym for matrix theory a concept from algebraic logic biomedicine matrix population models are used to model wildlife and human population dynamics the matrix model of substance abuse treatment is a model developed by the matrix institute on addictions in the s to treat cocaine and methamphetamine addiction protein complexes a matrix model of protein complexes unrealistically predicts that all proteins in a complex interact with all other proteins mathematically a matrix model of a protein complex is a complete graph management and economics the term matrix model is used to describe matrix management where each worker in an organisation has two managers one functional managing their expertise the other executive managing thei...
https://en.wikipedia.org/wiki/Matrix_model
*  Ehrenpreis' fundamental principle
ehrenpreis fundamental principle ehrenpreis fundamental principle in mathematical analysis ehrenpreis fundamental principle introduced by leon ehrenpreis states http link springer com content pdf pdf every solution of a system in general overdetermined of homogeneous partial differential equation s with constant coefficient s can be represented as the integral with respect to an appropriate radon measure over the complex characteristic variety of the system references category mathematical analysis...
https://en.wikipedia.org/wiki/Ehrenpreis'_fundamental_principle
*  Nonlinear Elliptic and Parabolic Partial Differential Equations
... held at politecnico di milano dept of mathematics aula b edificio la nave milano via bonardi june the purpose of the workshop is to bring together specialists in the field of elliptic and parabolic nonlinear partial differential equations in order to emphasize future theoretical trends and their applications among other topics the workshop will focus on qualitative properties of solutions to elliptic equations regularity of solutions asymptotic behavior of solutions to parabolic equations new equations from mathematical physics and biology the workshop also aims to be a good state of art information for young researchers speakers program leaflet organization registration this conference is sponsored by gruppo nazionale per l analisi matematica la probabilitã e le sue applicazioni dipartimento di matematica politecnico di milano fondo di ricerca di ateneo analisi di problemi variazionali e differenziali prin aspetti geometrici delle equazioni alle derivate parziali e questioni connesse and prin metodi di ...
http://www2.mate.polimi.it/ocs/?cf=39
*  Proving a Probability Generating Function satisfies a partial differential Equation - Mathematics St
... ack Exchange. Proving a Probability Generating Function satisfies a partial differential Equation. If an animal is resting at time t, the probability it begins grazing in the interval between $t$ and $t+h$ is $\lambda h+o h $, and if it is grazing at time t, the probability it will begin resting between $t$ and $t+h$ is $\mu h+o h $. Let $X t $ denote the number of animals grazing at time $t\ge 0$ We need to show that the pgf $P\left t,s\right =E\left s \left Xt\right \right $ satisfies: $${\partial P\over \partial t}= \left 1-s\right \left \mu+\lambda s\right {\partial P\over \partial s}+N\lambda \left s-1\right P$$ The problem I have is in finding the forward Kolmogorov equations, since we need to adjust the birth and death coefficients, and I don't really know how to alter the baseline case. The transition intensities of the process $ X t _t$ are, for every $0\leqslant x\leqslant N$, $x\to x+1$ at rate $\lambda\cdot N-x $ this corresponds to the event that an animal resting at time $t$ begins to graze ...
http://math.stackexchange.com/questions/356622/proving-a-probability-generating-function-satisfies-a-partial-differential-equat
*  Modification of the simple mass balance equation for calculation of critical loads of acidity. - N
... ERC Open Research Archive. nerc.ac.uk. Modification of the simple mass balance equation for calculation of critical loads of acidity. Tools Tools Tools. RDF+XML BibTeX RDF+N-Triples JSON RefWorks Dublin Core Simple Metadata Refer METS Simple Metadata iShare HTML Citation ASCII Citation OpenURL ContextObject EndNote Dublin Core iShare OpenURL ContextObject in Span MODS MPEG-21 DIDL EP3 XML Reference Manager RDF+N3 Multiline CSV. 1995 Modification of the simple mass balance equation for calculation of critical loads of acidity. Mapping and modelling of critical loads for nitrogen - a workshop report. Abstract/Summary Over the last few years, the simple mass balance equation for the calculation of critical loads of acidity has been gradually modified as the underlying critical load concepts have developed and as problems with particular forms of the equation have been identified, through application in particular countries. The workshop was held to discuss problems which had been identified when the then cur...
http://nora.nerc.ac.uk/7285/
*  BISSELL Stain Trapper Tool 160-0057 | Deep Cleaner Parts
Deep Cleaner Parts. Carpet Cleaners. Carpet Cleaners Upright. Carpet & Floor Cleaning Formulas. Carpet & Floor Cleaning Formulas Upright. Attach this tool to your BISSELL carpet cleaner to spray, scrub and suction extra-gross, extra-stinky messes Messes are collected and stored in a separate, removable container that twists off for easy emptying and disposal Self-contained tool keeps pet and other liquid messes inside the tool and out of your machine Tool is compatible with the following BISSELL models: 5207, 9749, 7786 series, 47A2, 17N4, 36Z9 series, 8852 series, 7901, 9200 series Watch the stain trapper tool in action. 8852 Model Shown: 8852 Similar Models: 1210, 88522, 88523, 88524, 8852T, 9585. AutoCare ProHeat® 1425-6 Model Shown: 14256 Similar Models: 14254, 14255, 1425D, 1425F, 1425T. 86T3 Model Shown: 86T3 Similar Models: 86T32, 86T38, 86T3F, 86T3Q, 86T3V. 47A2 Model Shown: 47A2 Similar Models: 47A21, 47A22, 47A24, 47A26, 47A2R, 47A2T, 80R4. 17N4 Model Shown: 17N4 Similar Models: 17N42, 17N43, 17N45,...
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*  pde - energy norm for transport equation - Computational Science Stack Exchange
... current community. chat blog. Computational Science. . Computational Science Meta. your communities. Sign up or log in to customize your list. more stack exchange communities. Stack Exchange. Inbox. Reputation and Badges. sign up log in tour. help. Tour Start here for a quick overview of the site. Help Center Detailed answers to any questions you might have. Meta Discuss the workings and policies of this site. Computational Science beta. Questions. Tags. Users. Badges. Unanswered. Ask Question. Sign up. Computational Science Stack Exchange is a question and answer site for scientists using computers to solve scientific problems. It's 100% free, no registration required. energy norm for transport equation. up vote 1 down vote favorite. I asked this question before but did not have any luck with an answer. It might be a student level question but I need to understand that with possibly some help. I am considering the hyperbolic equation of the form $$u t+\frac{x}{T-t}u x=0$$ and some initial data $u x,...
http://scicomp.stackexchange.com/questions/4914/energy-norm-for-transport-equation
*  Stage 5 Mechanics mapping document :: Differential Equations in mechanics : nrich.maths.org
... nrich enriching mathematics Skip over navigation Main menu Search. accessibility contact Skip over navigation Terms and conditions. Home. Home Students. Guide and features Teachers. Guide and features. early years. Featured Early Years Foundation Stage; US Kindergarten Early years. primary. Featured UK Key Stage 1 2; US Grades 1-5 Primary teachers. secondary. Featured UK Key Stage 3-5; US Grades 6-12 Secondary teachers. primary lower. Featured UK Key Stage 1, US Grade 1 2 primary. primary. Featured UK Key Stage 2; US Grade 3-5. secondary lower. Featured UK Key Stages 3 4; US Grade 6-10 secondary. secondary upper. Featured UK Key Stage 4 5; US Grade 11 12. Topics. STEM. Science, Technology, Engineering and Mathematics. Events. Events. translate. Search by Topic. Resources tagged with Differential Equations in mechanics similar to Phase Space :. Filter by: Content type: ALL Problems Articles Games Stage: All Stage 1 2 Stage 2 3 Stage 3 4 Stage 4 5. Challenge level:. Other tags that relate to Phase Space 1s...
http://nrich.maths.org/public/leg.php?code=-650&cl=4&cldcmpid=7107
*  human biology - What biological systems are affected by Vitamin B6 (or B vitamins in general)? - Bio
human biology - What biological systems are affected by Vitamin B6 or B vitamins in general. - Biology Stack Exchange. current community. chat blog. Biology. . Biology Meta. your communities. Sign up or log in to customize your list. more stack exchange communities. Stack Exchange. Inbox. Reputation and Badges. sign up log in tour. help. Tour Start here for a quick overview of the site. Help Center Detailed answers to any questions you might have. Meta Discuss the workings and policies of this site. Biology Questions. Tags. Users. Badges. Unanswered. Ask Question. Sign up. Biology Stack Exchange is a question and answer site for biology researchers, academics, and students. It's 100% free, no registration required. What biological systems are affected by Vitamin B6 or B vitamins in general. up vote 5 down vote favorite. B vitamins and particularly the B6 vitamin appears to the one of the main ingredients in energy drinks. There has been anecdotal evidence from people interested in dreaming that ingestion ...
http://biology.stackexchange.com/questions/2457/what-biological-systems-are-affected-by-vitamin-b6-or-b-vitamins-in-general/2514
*  JCI - Volume 117, Issue 12
... Clinical Medicine JCI This Month Current issue Past issues. The Journal of Clinical Investigation. Issue published December 3, 2007. Published December 3, 2007. Citation Information: J Clin Invest. doi: 10.1172/JCI34323. View: Text PDF. Text PDF. Abstract. Authors. Published December 3, 2007. Citation Information: J Clin Invest. doi: 10.1172/JCI34430. View: Text PDF. Text PDF. Abstract. Authors. Published December 3, 2007. Citation Information: J Clin Invest. doi: 10.1172/JCI33677. View: Text PDF. Text PDF. Abstract. Authors. David B. David B. Published December 3, 2007. Citation Information: J Clin Invest. doi: 10.1172/JCI33611. View: Text PDF. Text PDF. Abstract. Authors. David B. Published December 3, 2007. Citation Information: J Clin Invest. doi: 10.1172/JCI34288. View: Text PDF. Text PDF. Abstract. Authors. The concept that injury to the endothelium may precede airway fibrosis suggests that interventions to maintain vascular integrity may be important, especially in the case of lung transplantation...
http://jci.org/117/12
*  .. Clustering RabbitMQ on Windows .. A Trip to CQRS – New Views ..
Clustering RabbitMQ on Windows. It may not exactly be the NancyFX Super-Duper-Happy-Path™, but it comes closer to it than any other ServiceBus/Broker I’ve come across. However, the first time I laid eyes on the RabbitMQ guidance for Distribution, High Availability, and Clustering I started thinking that ... read more →. Development. .NET MassTransit RabbitMQ. A Trip to CQRS – New Views. The entire series is here: Intro Commands Events Authoritative Events New Views We finally have a reasonably flexible architecture to play with. read more →. Code · Development. .NET Architecture CQRS. A Trip to CQRS – Authoritative Events. The entire series is here: Intro Commands Events Authoritative Events New Views I left you in the previous post with a bit of a cliff-hanger, didn’t I. read more →. Code · Development. .NET Architecture CQRS. A Trip to CQRS – Events. The entire series is here: Intro Commands Events Authoritative Events New Views In my last post, the system was introduced to Commands in order to structur...
http://coding-insomnia.com/
*  2009 Foals - How are they doing - post pics
... Horse Forums. Horses. The Horse Forum. Horse Breeding. 2009 Foals - How are they doing - post pics. User Name. Password. Register Horses FAQ Calendar Search Today's Posts Mark Forums Read. 2009 Foals - How are they doing - post pics This is a discussion on 2009 Foals - How are they doing - post pics within the Horse Breeding forums, part of the Horse Breeds, Breeding, and Genetics category Foal fur 6month old colt. LinkBack Thread Tools. 07-25-2009, 01:50 PM. User. Horses. 2009 Foals - How are they doing - post pics Okay, I will start it. Had to take shots for registration and thought I would post a link - no more baby fur at four months - Here is Prospect's Danika - Filly by ES Donavan Hano out of Prospect's Atheana - CSHA Approved Clyde/Hackney born March 29, 2009 - currently standing at 13.3hh How are everyone else's babies doing - lets see some pics. 07-25-2009, 01:55 PM. User. Horses. 07-25-2009, 02:01 PM. User. Horses. 07-25-2009, 02:11 PM. User. Horses. 07-25-2009, 02:36 PM. User. Horses. Both bab...
http://horseforum.com/horse-breeding/2009-foals-how-they-doing-post-32429/
*  JCI - Growing a tumor stroma: a role for granulin and the bone marrow
... Reviews. Reviews View all reviews... Article tools. View PDF. Share this article. Top Abstract Background: systemic tumor instigation GRN+Sca1+cKit–CD45+ cells mediate systemic instigation Progranulin in human breast cancers Context and questions Conclusions References. Find articles by Bateman, A. PubMed. Google Scholar. Commentary See the related article beginning on page 784. Figure 1 The role of GRN + Sca-1 + cKit – BMCs in systemic instigation and the formation of tumor stroma. The Sca1 + cKit – BMCs accumulate at the responder tumor and stimulate reactive stroma formation ref. 7 report for the first time the mechanism by which Sca1 + cKit – BMCs instigate the formation of a reactive stroma in indolent responder tumors in mice. GRN + Sca1 + cKit – CD45 + cells mediate systemic instigation. BMCs from mice with instigator tumors were sorted into Sca1 + cKit –, Sca1 + cKit +, and Sca1 – cells and comixed with responder cancer cells before transplantation into mice that did not bear contralateral instig...
http://jci.org/articles/view/46088?key=d7dca6a27fa8539cece0
*  Chapman–Enskog theory
... 'Chapman–Enskog' theory presents accurate formulas for a multicomponent gas mixture under thermal and chemical equilibrium. In elastic gases the deviation from the Maxwell–Boltzmann distribution in the equilibrium is small and it can be treated as a perturbation. This method was aimed to obtain transport equations more general than the Euler equations. It is named for Sydney Chapman and David Enskog. Chapman–Enskog Expansion Mathematical Formulation See also Bibliography. Chapman–Enskog Expansion. Solutions to the Navier–Stokes equations can be used to describe many fluid-dynamical phenomena such as laminar flows, turbulence and solitons. Fundamentally, the Navier-Stokes equation is derived from the Boltzmann equation. If particular models of the microscopic collision process are applied, explicit formulas for the transport equations can be acquired. The term Chapman-Enskog Expansion denotes this derivation of the Navier-Stokes equation and its transport coefficients from the Boltzmann equation and certa...
https://en.wikipedia.org/wiki/Chapman–Enskog_theory
*  KLUEDO | Fachbereich Mathematik
Axel Klar 19. kinetic equations 2. CFL type conditions 1. Particle Methods 1. 19 search hits. search hits 1 to 10. An asymptotic preserving numerical scheme with respect to diffusion scalings for a linear transport equation is investigated. A discrete velocity model with spatial and velocity discretization based on a lattice Boltzmann method is considered in the low Mach number limit. An adaptive domain decomposition procedure for Boltzmann and Euler equations 1998. In this paper we present a domain decomposition approach for the coupling of Boltzmann and Euler equations. Particle methods are used for both equations. An Asymptotic-Induced Scheme for Nonstationary Transport Equations in the Diffusive Limit 1997. Axel Klar. An asymptotic-induced scheme for nonstationary transport equations with thediffusion scaling is developed. It is based on the asymptotic analysis of the diffusion limit ofthe transport equation. Convergence of Alternating Domain Decomposition Schemes for Kinetic and Aerodynamic Equations 199...
https://kluedo.ub.uni-kl.de/solrsearch/index/search/searchtype/collection/id/15997/start/0/rows/10/has_fulltextfq/true/author_facetfq/Axel Klar
*  Browsing Centre for Systems, Dynamics and Control by Title
... Site map. Browsing Centre for Systems, Dynamics and Control by Title. Centre for Systems, Dynamics and Control. Browsing Centre for Systems, Dynamics and Control by Title. Centre for Systems, Dynamics and Control. Browsing Centre for Systems, Dynamics and Control by Title. Browsing Centre for Systems, Dynamics and Control by Title. Cycling chaotic attractors in two models for dynamics with invariant subspaces . Ashwin, Peter ; Rucklidge, Alastair M. American Institute of Physics , 2004. Ashwin, Peter ; Sturman, Rob. Elsevier , 2003. Ashwin, Peter ; Borresen, Jon. Elsevier , 2005. Dynamics on networks of cluster states for globally coupled phase oscillators . Ashwin, Peter ; Orosz, G bor ; Wordsworth, John ; Townley, Stuart. Society for Industrial and Applied Mathematics , 2007. Systems of globally coupled phase oscillators can have robust attractors that are heteroclinic networks. Ashwin, Peter. We study properties of the dynamics underlying slow cluster oscillations in two systems of five globally cou...
https://ore.exeter.ac.uk/repository/handle/10036/19040/browse?order=ASC&rpp=20&sort_by=1&etal=-1&offset=8&type=title
*  Differential & Difference Equations | Mathematical Association of America
Differential & Difference Equations. Minicourses. You are here Home » Differential & Difference Equations Differential & Difference Equations. Paul s Online Math Notes: Modeling with Differential Equations Course Community COMAP Collection of ILAPs Course Community Epidemiology: Modeling Epidemics and Endemics Course Community Interactive Mathematics Course Community EqWorld Course Community Wolfram Alpha Course Community Interactive Math Programs Course Community Herd Immunity for Smallpox Course Community DESSolver v1.7 Course Community Wolfram Demonstrations: Search Runge-Kutta Course Community Phase Plotter Applet Course Community Six Portraits of a Linear System of ODEs Course Community Phase Plane of Two ODEs Course Community JOde: A Java Applet for Studying Ordinary Differential Equations Course Community Phase Protraits for ODEs and Autonomous Systems Course Community Diffusion, Fick s Law Course Community Laplace Transforms IDE Course Community Poles of the Laplace Transform and Behavior of Solutions...
http://maa.org/publications/periodicals/loci/differential-difference-equations-243?page=5
*  John's equation
... 'John's equation' is an ultrahyperbolic partial differential equation satisfied by the X-ray transform of a function. It is named after Fritz John. Given a function f\colon\mathbb{R} n \rightarrow \mathbb{R} with compact support the 'X-ray transform' is the integral over all lines in \mathbb{R} n. We will parameterise the lines by pairs of points x,y \in \mathbb{R} n, x \ne y on each line and define ' u ' as the ray transform where : u x,y = \int\limits {-\infty} {\infty} f x + t y-x dt. Such functions ' u ' are characterized by John's equations : \frac{\partial 2u}{\partial x i \partial y j} - \frac{\partial 2u}{\partial y i \partial x j}=0 which is proved by Fritz John for dimension three and by Kurusa for higher dimensions. In three-dimensional x-ray computerized tomography John's equation can be solved to fill in missing data, for example where the data is obtained from a point source traversing a curve, typically a helix. More generally an 'ultrahyperbolic' partial differential equation a term coine...
https://en.wikipedia.org/wiki/John's_equation
*  New insights into the surface / atmosphere exchange of particles based on recent advances in measur
... ement technology - NERC Open Research Archive. nerc.ac.uk. Help. Contact us. Home. About. Browse. Search. Statistics. NERC Staff Login. New insights into the surface / atmosphere exchange of particles based on recent advances in measurement technology. Tools Tools Tools. RDF+XML BibTeX RDF+N-Triples JSON RefWorks Dublin Core Simple Metadata Refer METS Simple Metadata iShare HTML Citation ASCII Citation OpenURL ContextObject EndNote Dublin Core iShare OpenURL ContextObject in Span MODS MPEG-21 DIDL EP3 XML Reference Manager RDF+N3 Multiline CSV. Nemitz, E. ; Phillips, G. J ; Thomas, R. ; di Marco, C. F ; Fowler, D. 2009 New insights into the surface / atmosphere exchange of particles based on recent advances in measurement technology. Eos, Transactions, American Geophysical Union, 90 52 Fall Meet. Su, Abstract A54D-02. Full text not available from this repository. Official URL: http://www.agu.org/meetings/fm09/waisfm09.html Abstract/Summary Dry deposition velocities of particles govern the deposition and a...
http://nora.nerc.ac.uk/9344/
*  How are internal models of unstable tasks formed? - CUED Publications database
how are internal models of unstable tasks formed cued publications database cued publications database home about browse by year browse by division login how are internal models of unstable tasks formed burdet e and franklin dw and osu r and tee kp and kawato m and milner te how are internal models of unstable tasks formed in unspecified pp full text not available from this repository abstract the results of recent studies suggest that humans can form internal models that they use in a feedforward manner to compensate for both stable and unstable dynamics to examine how internal models are formed we performed adaptation experiments in novel dynamics and measured the endpoint force trajectory and emg during learning analysis of reflex feedback and change of feedforward commands between consecutive trials suggested a unified model of motor learning which can coherently unify the learning processes observed in stable and unstable dynamics and reproduce available data on motor learning to our knowledge this algor...
http://publications.eng.cam.ac.uk/366409/
*  Series Solution to Ordinary Differential Equation Recurrence Relation - Who Posted?
series solution to ordinary differential equation recurrence relation who posted total posts who posted posts creebe show thread close window...
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*  How are these results on SD possible??? - AnabolicMinds.com
How are these results on SD possible??. News. Supplement News. Nutrition News. Weight Loss News. Training News. Men's Health News. Contest News. Research News. Forum. Supplement Forum. Nutrition Forum. Weight Loss Forum. Training Forum. Main Forum. Supplement Forum. Company Promotions. Nutrition Forum. Weight Loss Forum. Training Forum. Bodybuilding Forum. General Chat. 1RM Supplements. Island Supplements. Orbit Supplements. PHW Supplements. Strong Supplements. TF Supplements. TGB Supplements. Album Gallery. Member Gallery. Forum. How are these results on SD possible??. How are these results on SD possible??. How are these results on SD possible??. Being a former fat ****, I've always been one to be concerned about my weight... Whenever it goes up, even if I know I'm losing fat, I get worried, so when I stepped on the scale today on the last day of my superdrol cut I freaked out. I decided to go on a 1000 cal deficit with carbs less than 120g per day, and 10mg of superdrol. In 4 weeks, my waist dropped about ...
http://anabolicminds.com/forum/steroids/50362-how-these-results.html
*  Newest Unholy Dk Changes - How are you guys liking it ?? PVP
Newest Unholy Dk Changes - How are you guys liking it ?. PVP. Remember Me. Need an account. Register Now. Contact Us. Home. Forum. Rules. Forum Actions. Mark Forums Read. Videos. What's New. MMO-Champion. Forum. Class Discussions. Death Knight ». Newest Unholy Dk Changes - How are you guys liking it ?. PVP. . Thread: Newest Unholy Dk Changes - How are you guys liking it ?. PVP. Thread Tools. Show Printable Version. Email this Page. Subscribe to this Thread. 2013-01-31, 01:53 PM. #1. . a C e. View Profile. View Forum Posts. Private Message. View Started Threads. Mechagnome. Join Date Aug 2012 Location Dubai, Shiraz or Under The Trees of Mulgore Posts 601. Newest Unholy Dk Changes - How are you guys liking it ?. PVP. Will Dk be one of the top melee classes again after these changes and are they going to be competitive in 3v3 arenas. Reply With Quote. 2013-01-31, 03:11 PM. #2. . Bazookaberit. View Profile. View Forum Posts. Private Message. View Started Threads. High Overlord. Join Date May 2012 Posts 168. They ...
http://mmo-champion.com/threads/1257855-Newest-Unholy-Dk-Changes-How-are-you-guys-liking-it-PVP?p=20055122&viewfull=1
*  A Conventional Model of Process Mapping - NHS Institute for Innovation and Improvement
... This tool will help you to map the whole patient journey or diagnostic pathway with a range of people who represent the different roles involved. Mapping the whole patient journey will help you to look for opportunities for improvement by visualising how the whole patient journey currently works and identifying points of inefficiency. It also sparks good ideas and helps a team to know where to start to make improvements that will have the biggest impact for patients and staff. It will help staff understand how complicated the systems can be for patients, showing how many times the patient has to wait often unnecessarily and how many different people a patient meets. To get you started, here are some things to think about when starting to plan a mapping session: What is the purpose of the session. Remember, the process map will only be as good as the list of people who attend, there will be gaps in it if some staff do not attend. This can be useful if people do not usually work together. 1 Start with a hi...
http://institute.nhs.uk/index2.php?option=com_content&task=view&id=2222&pop=1&page=0&Itemid=5015
*  * UNANSWERED QUESTIONS: RESPONSE *
... Anthony J. anthonyp at scripps.edu. Previous message: * UNANSWERED QUESTIONS: RESPONSE * Next message: * UNANSWERED QUESTIONS: RESPONSE * Messages sorted by:. Each of these quest- ions highlights a contradiction *within* current views; for example, a everyone agrees that intracellular movements can be seen by low power light microscopy in living cells, yet most people also believe that there is a cytoskeleton, which would not permit such movements; I don't understand your conlusion. So it is in no way obvious that the presence of intracellular movement is inconsistent with a cytoskeleton. It is inconsistent if and only if the cytoskeleton is a rigid network whose effective pore size is smaller than the molecules that must diffuse through it. Biochemistry, immunofluorescence and genetic evidence all support the idea that these proteins have a portion outside the membrane and one inside, that the region inside assciates with proteins we consider part of the cytoskeleton, and that these associations are nec...
http://bio.net/bionet/mm/neur-sci/1996-June/024255.html
*  genetics - How are geneticists able to isolate gene functions? - Biology Stack Exchange
genetics - How are geneticists able to isolate gene functions. - Biology Stack Exchange. Biology. Biology Meta. more stack exchange communities. Stack Exchange. sign up log in tour. Tour Start here for a quick overview of the site. Help Center Detailed answers to any questions you might have. Biology Questions. Sign up. Biology Stack Exchange is a question and answer site for biology researchers, academics, and students. How are geneticists able to isolate gene functions. genetics genomics dna-sequencing share. LanceLafontaine Mar 29 '13 at 3:36. @LanceLafontaine if you have a more detailed answer, please submit it as an answer rather than a comment. up vote 3 down vote. @LanceLafontaine suggested a few ways above, but I would recommend reading this section in Alberts' Molecular Biology of the Cell, which gives a more descriptive overview of some approaches, but even that is not exhaustive. observe mutants, see what processes are disrupted, and map these back to particular mutations mutate a gene and see what...
http://biology.stackexchange.com/questions/7694/how-are-geneticists-able-to-isolate-gene-functions?answertab=active
*  We're so going to E-Hell... (3 new questions on post 15)
We're so going to E-Hell... 3 new questions on post 15. About. The Ehell Blog. Civilized Politics. Hells Bells. The Story Archives. "Where The Civil People Meet". News: All new forum theme. See Forum Announcements for more information. Home. Help. Search. Login. Register. October 06, 2015, 09:40:16 PM. 1 Hour 1 Day 1 Week 1 Month Forever. Login with username, password and session length. Etiquette Hell. Wedding Bliss and Blues. Gifts, Registries and Money. We're so going to E-Hell... 3 new questions on post 15. previous next Print. Pages: 1 2 4 5 6 7 8. Go Down. Author Topic: We're so going to E-Hell... 3 new questions on post 15 Read 15358 times. 0 Members and 1 Guest are viewing this topic. TurtleDove Super Hero. Posts: 6855. . Re: We're so going to E-Hell... 3 new questions on post 15 Reply #30 on: March 10, 2014, 04:09:05 PM. Quote from: Diane AKA Traska on March 10, 2014, 03:35:36 PM. Maybe it s just me, but I ve heard so many variations of We had a wonderful two weeks, Hawaii was great, I m sure the bea...
http://etiquettehell.com/smf/index.php?topic=132668.msg3117773
*  Engine tunes recommendation? - Page 2
03-28-2012, 04:29 PM # 23. 877 Rep. 12,155 Posts. Drives: BMW Join Date: Nov 2005 Location: Anaheim, CA. iTrader: 15. Quote: Originally Posted by M3PO. Appreciate 0. View Public Profile. Find More Posts by tom @ eas. 03-28-2012, 04:30 PM # 24. 40 Rep. 2,793 Posts. Drives: '08 IB E92 Join Date: Sep 2011 Location: OC. iTrader: 7. Quote: Originally Posted by Singletrack. Appreciate 0. View Public Profile. Find More Posts by M3PO. 03-28-2012, 04:37 PM # 25. 63 Rep. 5,278 Posts. iTrader: 3. The plausibility/ rationality check of the post – catalyst oxygen sensor covers four diagnostic strategies: -Diagnostic during fuel cut off, to verify if the signal is below a certain threshold while in fuel cut off P013E/ P014A -Diagnostic during fuel cut off, validation of the transition time P013A/ P013C -Diagnostic during re-injection after fuel cut off, validation of the signal gradient P013B/ P013D -Diagnostic during wide open throttle, to verify if the signal climbs above a certain threshold in WOT P0136/ P0156 Active Te...
http://m3post.com/forums/showthread.php?t=668354&page=2
*  Aiki Physical Model -- Structure & Dynamic - AikiWeb Aikido Forums
Aiki Physical Model -- Structure Dynamic - AikiWeb Aikido Forums. AikiWeb Aikido Forums. AikiWeb Aikido Forums. Aiki Physical Model -- Structure Dynamic. Erick Mead. Florida Aikikai Location: West Florida Join Date: Jun 2005 Posts: 2,553. Offline. Aiki Physical Model -- Structure Dynamic Two basic physical models seem appropriate for the human body. Cordially, Erick Mead 一隻狗可久里馬房但他也不是馬的. Erick Mead. View Public Profile. Find More Posts by Erick Mead. Visit Erick Mead's AikiBlog. 10-07-2009, 12:24 PM # 2. Dojo: Aozora Dojo Location: Birmingham, AL Join Date: Feb 2006 Posts: 1,508. I myself have lately been thinking of the dynamic as being like a basket of woven bamboo more or less a torsion tube with lots of flex, but also a lot of self-interference which acts to support the structure. Re: Aiki Physical Model -- Structure Dynamic With respect to the gyroscopics:. Quote: part quoted here http://www.aikiweb.c...
http://aikiweb.com/forums/showthread.php?t=14741
*  Physiologically based pharmacokinetic modelling
... 'Physiologically based pharmacokinetic PBPK modeling' is a mathematical modeling technique for predicting the absorption, distribution, metabolism and excretion ADME of synthetic or natural chemical substances in humans and other animal species. Modelling inputs. Modelling metabolism. Uses of PBPK modeling Limits and extensions of PBPK modelling References Forums Software. 9 Compartments are usually defined by grouping organs or tissues with similar blood perfusion rate and lipid content 'i.e.' organs for which chemicals' concentration 'vs.' time profiles will be similar. In that case; for a generic compartment 'i', the differential equation for the quantity 'Q i ' of substance, which defines the rate of change in this quantity, is:. {dQ i \over dt} = F i C {art} - {{Q i} \over {P i V i}}. {dQ g \over dt} = F g C {art} - {{Q g} \over {P g V g}}. {dQ k \over dt} = F k C {art} - {{Q k} \over {P k V k}}. {dQ p \over dt} = F p C {art} - {{Q p} \over {P p V p}}. {dQ b \over dt} = F b C {art} - {{Q b} \over {P...
https://en.wikipedia.org/wiki/Physiologically_based_pharmacokinetic_modelling
*  Road mapping could be key to curing TB
... February 5, 2010 Road mapping could be key to curing TB February 5, 2010 The complex chain of metabolic events in bacteria that lead to fatal diseases such as tuberculosis TB may be better understood using mathematical models, according to an article published in the February issue of Microbiology Today. The classic approach to understanding biological functions in mammals and microbes alike has been based on the assumption that a single gene is primarily responsible for a single function - which can be inhibited by simply blocking the gene. Professor Johnjoe McFadden who works on TB at the University of Surrey likens metabolic pathways in cells to Britain's road network. "For example, we may identify a particular road, say the A45, that takes goods from Birmingham to Coventry and call it the BtoC road - or BtoC gene," he said. In truth, the 'road' or gene from BtoC isn't just the A45, but includes all those other routes." A good starting point to study functional pathways is a mathematical model of the ...
http://phys.org/news/2010-02-road-key-tb.html
*  Greg, How Are You? - The Slow Inexorable Ascent
Greg, How Are You. Greg, How Are You. Caretakers Corner Extrania Mail Call Picture PPL PLCS THNGS The Days Uncategorized. Commemorating Greg’s life by Dave Gross on Aug.12, 2012, under Uncategorized. 8 Comments. No Cell by greg on Jul.21, 2012, under The Days Yes, I am most remiss in my duties. At at that, I get to my laptop last thing in day. Medical first, guests first, getting some time away from my room second if possiible. 7 Comments. Rise and Shine Festival, GO. by greg on Jul.19, 2012, under Caretakers Corner, The Days http://thedolab.com/blog/event/rise-shine-gathering-a-conscious-living-event/. 2 Comments. by greg on Jul.15, 2012, under Uncategorized Summary : Slow and steady is gonna win this race. Very slow. Very steady. Day Transplant+67, post infusion. I have a spreadsheet of the days here. Bowels : Angry, angry, angry. Diarrhea day 50. It doesn t need saying but, this is getting really old. But they say good most days. Steroids at 50 mg twice a day. I did not get a bike. So I choose group therap...
http://greghowareyou.com/
*  Abiogenesis by Self-Organization (for the Origin of Life)
Abiogenesis by Self-Organization for the Origin of Life. Abiogenesis for the Origin of Life by Self-Organization. Is it possible that simple organic molecules could self-organize into a living, reproducing organism. Second, when enough of these molecules were concentrated together, they formed an interacting auto-catalytic system that jointly catalyzed their mutual reproduction. Life is a complex web of interactions where proteins are required for nucleic acid synthesis and nucleic acids are required for protein synthesis. Similarly, the metabolites that fuel it are the synthetic precursors for protein and nucleic acid synthesis, yet they require proteins for their own synthesis. The replicating closed auto-catalytic system described by Stuart A. Stuart Kaufmann The Origins of Order: Self-Organization and Selection in Evolution, p. 285 writes, ...this new view, which is based on the discovery of an expected phase transition from a collection of polymers which do not reproduce themselves to a slightly more com...
http://asa3.org/ASA/education/origins/cheme-lhtg.htm
*  Mixture theory
... is used to model multiphase systems using the principles of continuum mechanics generalised to several interpenetrable continua the basic assumption is that at any instant of time all phases are present at every material point and momentum and mass balance equations are postulated like other models mixture theory requires constitutive relations to close the system of equations krzysztof wilmanski extended the model by introducing a balance equation of porosity references category rheology category scientific modeling...
https://en.wikipedia.org/wiki/Mixture_theory
*  HPP model
... The 'HPP model' is a fundamental lattice gas automaton for the simulation of gases and liquids. It was a precursor to the lattice Boltzmann methods. From lattice gas automata, it is possible to derive the macroscopic Navier-Stokes equation s. Succi, section 2.3 describes the process Interest in lattice gas automaton methods levelled off in the early 1990s, due to rising interest in the lattice Boltzmann methods. Succi, section 2.6. History Model Collision Step. Transport Step. Shortcomings Notes References. The model can be used as a simple model for both the movement of gases and fluid. thumb|Visual examples of the four rules governing the HPP Model. In this model the lattice takes the form of a two-dimensional square grid, with particles capable of moving to any of the four adjacent grid points which share a common edge, and particles cannot move diagonally. Particles exist only on the grid points, never on the edges or surface of the lattice. Each particle has an associated direction from one grid poi...
https://en.wikipedia.org/wiki/HPP_model
*  How can I sort all my questions by date or by time when they where asked? - Meta Stack Exchange
How can I sort all my questions by date or by time when they where asked. - Meta Stack Exchange. Stack Exchange. Meta Stack Exchange. more stack exchange communities. Stack Exchange. Help Center Detailed answers to any questions you might have. What's Meta. Meta Stack Exchange Questions. What is meta. Meta Stack Exchange is where users like you discuss bugs, features, and support issues that affect the software powering all 150 Stack Exchange communities. How can I sort all my questions by date or by time when they where asked. This question already has an answer here: List of questions asked on account page 1 answer. How can I sort all my questions by date by time in that list that I get to after clicking on my user's name at the top of the screen right after the envelope icon. Update: I am sorry I forgot to mention that I want my questions to be sorted by the time they were asked, not by the time of their latest responds. And also, I would want to be able to see the oldest questions at the top of the li...
http://meta.stackexchange.com/questions/46703/how-can-i-sort-all-my-questions-by-date-or-by-time-when-they-where-asked
*  Characteristic equation
... may refer to characteristic equation calculus used to solve linear differential equations characteristic equation the equation obtained by equating to zero the characteristic polynomial of a matrix or of a linear mapping characteristic equation a polynomial used to solve a recurrence relation...
https://en.wikipedia.org/wiki/Characteristic_equation
*  Account Suspended
... This Account Has Been Suspended....
http://filmbitmez.com/cgi-sys/suspendedpage.cgi
*  Simple Tips that Make Moving Easier
......
http://lifehacker.com/5795111/simple-tips-that-make-moving-easier?tag=moving
*  Ways To Give
http://beverlyhospital.org/giving/ways-to-give/annual-giving
*  Ki-67 (protein)
'Antigen KI-67' also known as 'Ki-67' or 'MKI67' is a protein that in humans is encoded by the 'MKI67' gene antigen identified by monoclonal antibody Ki-67. Function Use as cell marker Antibody labeling MIB-1. Original Ki-67 antibody. Interactions See also Additional images References External links. Antigen KI-67 is a nuclear protein that is associated with and may be necessary for cellular proliferation. Furthermore, it is associated with ribosomal RNA transcription. Inactivation of antigen KI-67 leads to inhibition of ribosomal RNA synthesis. 4 Use as cell marker. Image:Ki-67 immunostain ing of a brain tumour with a high proliferative rate. The 'Ki-67' protein also known as 'MKI67' is a cellular marker for proliferation. 5 It is strictly associated with cell proliferation. Ki-67 protein is present during all active phases of the cell cycle G 1, S, G 2, and mitosis, but is absent from resting cells G 0. Antibody labeling. Ki-67 is an excellent marker to determine the growth fraction of a given cell populati...
https://en.wikipedia.org/wiki/Ki-67_(protein)
*  ki-67 protocol
... Previous Message. Next Message. From: carnek@dianon.com Kathy-Jean Carney by way of histonet To: histonet histonet@magicnet.net Reply-To:. Content-Type: text/plain; charset= us-ascii. Does anyone have a protocol for Ki-67 Zymed or Immunotech antibodies when tissue is fixed in Prefer. Our Immuno's are done by automation. We do not antigen retrieve with prefer, but is there something else we can do. We are getting all negative staining and I know some should be positive. Thanks Kathy. Previous Message. Next Message....
http://histosearch.com/histonet/Nov98/ki-67protocol.html
*  Waist Size and Body Mass Index Are Important Risk Factors for Sleep Disordered Breathing in Child
... ren - American Academy of Sleep Medicine AASM. SLEEP 2014. Waist Size and Body Mass Index Are Important Risk Factors for Sleep Disordered Breathing in Children. A study in the June 1 issue of the journal SLEEP found that waist circumference and body mass index BMI are consistent, independent risk factors for all severity levels of sleep disordered breathing SDB in children, suggesting that as with adult SDB, metabolic factors are important risk factors for childhood SDB. Results indicate that BMI and waist circumference, but not neck circumference, were significant and strong predictors of SDB at all severity levels primary snoring, mild SDB and moderate SDB. Nasal anatomic factors such as chronic sinusitis, rhinitis and nasal drain were significant predictors of mild SDB; minority status was associated with primary snoring and mild SDB. Overall, 1.2 percent of children had moderate SDB an apnea/hypopnea index of five or more breathing pauses per hour of sleep, 25 percent had mild SDB AHI of at least one ...
http://aasmnet.org/articles.aspx?id=1296
*  New Risk Factor for Dementia Discovered | dailyRx
New Risk Factor for Dementia Discovered. dailyRx. New Risk Factor for Dementia Discovered. Alzheimer's disease risk higher for people with high blood levels of ceramide. dailyRx News Looking for biomarkers of Alzheimer s disease AD may lead scientists to new treatments. Recent research discovered a new biomarker for AD ceramides in the blood. High levels of ceramides may mean higher risk of AD. The test looked at levels of ceramide in the blood. Researchers placed the women into categories based on the level of ceramide in their blood test low, middle and high levels of ceramide. Then they followed the women for up to nine years after the initial blood test and looked for how many women developed dementia or AD. Women with low levels of ceramide were eight times less likely to develop AD than those with the middle level of cermide. They were 10 times less likely to develop AD than women with the high level of ceramide. The researchers concluded that this easy, low-cost blood test could help in early detection...
http://dailyrx.com/alzheimers-disease-risk-higher-people-high-blood-levels-ceramide
*  JAMA Network | JAMA | Comparison of Novel Risk Markers for Improvement in Cardiovascular Risk Ass
Context Risk markers including coronary artery calcium, carotid intima–media thickness, ankle-brachial index, brachial flow–mediated dilation, high-sensitivity C-reactive protein CRP , and family history of coronary heart disease CHD have been reported to improve on the Framingham Risk Score FRS for prediction of CHD, but there are no direct comparisons of these markers for risk prediction in a single cohort. Objective We compared improvement in prediction of incident CHD/cardiovascular disease CVD of these 6 risk markers within intermediate-risk participants FRS 5%- 20% in the Multi-Ethnic Study of Atherosclerosis MESA. Conclusions Coronary artery calcium, ankle-brachial index, high-sensitivity CRP, and family history were independent predictors of incident CHD/CVD in intermediate-risk individuals. Risk markers that have shown promise in improving risk discrimination include carotid intima–media thickness CIMT , coronary artery calcium CAC scores, brachial flow–mediated dilation FMD , ankle-brachial index AB...
http://jama.jamanetwork.com/article.aspx?articleid=1352110
*  ADIPOGENIX, INC. | SBIR.gov
The STTR Program STTR Mission and Program Goals STTR Participating Agencies Three-Phase Program Competitive Opportunity for Small Business STTR Policy Directive Tibbetts Awards and Hall of Fame. PROGRAM/PHASE AWARD AMOUNT $ NUMBER OF AWARDS SBIR Phase I $499,560.00 6 SBIR Phase II $1,325,815.00 2. SBIR Phase I 1999 Department of Health and Human Services N/A Amount: $99,930.00 N/A. SBIR Phase I 2000 Department of Health and Human Services Anti-obesity drug development using human preadipocytes Amount: $0.00 N/A. SBIR Phase I 2001 Department of Health and Human Services Anti-obesity drug development using human preadipocytes Amount: $602,471.00 N/A. SBIR Phase II 2001 Department of Health and Human Services SECRETED PROTEIN FROM ADIPOCYTES AND PREADIPOCYTES Amount: $99,820.00 DESCRIPTION provided by applicant : Obesity is a well-established risk factor for a number of diseases, including type 2 diabetes and coronary heart disease. SBIR Phase I 2002 Department of Health and Human Services New Agents That Inhibi...
https://sbir.gov/sbirsearch/detail/72185?quicktabs_award-display-style=1
*  WHO | Biological risk factors and hazards
WHO. Biological risk factors and hazards. Skip to main content. Access Home Alt+0. Navigation Alt+1. Content Alt+2. Search Search the WHO .int site. Submit. Advanced search. Navigation Home. Health topics. Data. Media centre. Publications. Countries. Programmes. Governance. About WHO. Language عربي. 中文. English. Français. Русский. Español. RSS Feed. Youtube. Twitter. Facebook. Google +. iTunes. Play Store. Occupational health. Menu Occupational health. Topics. Activities. Collaborating centres network. Publications. Regions and partners. Links. . Biological risk factors and hazards Related sites Protecting health-care workers - preventing needlestick injuries tool kit. Joint WHO/ILO guidelines on post-exposure prophylaxis PEP to prevent HIV infection. HIV/AIDS site. Stop TB. Tuberculosis and HIV. AIRBORNE - A journey into the challenges and solutions to stopping MDR-TB and XDR-TB. SARS site. Injection safety pdf, 81kb. Guiding principles to ensure injection device security pdf, 99kb. Injection safety - SIGN. ...
http://who.int/occupational_health/topics/risks_biological/en/
*  Determining the Role of Subclinical Disease Testing in Patients at Intermediate Risk - NHLBI, NIH
... NHLBI Trials At NIH Clinical Center. Determining the Role of Subclinical Disease Testing in Patients at Intermediate Risk. TABLE OF CONTENTS. Background Review of Previous Recommendations Subclinical CVD and the Framingham Risk Score Subclinical Disease Testing: Study Design Review of Subclinical Disease Measures Clinical Screening Algorithms Population Considerations Interventions Outcomes Recommendations and Remaining Issues References Working Group Roster Planning Group Roster. The objective of the Working Group was to provide advice to the National Heart, Lung, and Blood Institute about research that is currently needed to inform clinical guidelines for the use of subclinical cardiovascular disease testing to identify persons at high risk for CVD and to target intervention. that is, a 10-year risk for coronary heart disease of 6-20%. Back to Table of Contents. Persons at intermediate risk have the greatest likelihood of having their estimated risk altered by subclinical disease testing. Coronary calc...
http://nhlbi.nih.gov/research/reports/2004-subclinical
*  The projected impact of population and high-risk strategies for risk-factor control on coronary hear
... t disease and stroke events - DRO. Home. Library. DRO home. . You are not logged in. Submit research. Contact DRO. DRO. The projected impact of population and high-risk strategies for risk-factor control on coronary heart disease and stroke events Vartiainen, Erkki, Laatikainen, Tiina, Philpot, Benjamin, Janus, Edward, Davis-Lameloise, Nathalie and Dunbar, James 2011, The projected impact of population and high-risk strategies for risk-factor control on coronary heart disease and stroke events, Medical journal of Australia, vol. 194, no. 1, pp. 10-15. Attached Files. Name Description MIMEType Size Downloads. Title. The projected impact of population and high-risk strategies for risk-factor control on coronary heart disease and stroke events. Author s. Vartiainen, Erkki Laatikainen, Tiina Philpot, Benjamin Janus, Edward Davis-Lameloise, Nathalie Dunbar, James. Journal name. Medical journal of Australia. Volume number. 194. Issue number. 1. Start page. 10. End page. 15. Publisher. Australasian Medical Publi...
http://dro.deakin.edu.au/view/DU:30032116
*  .. .. Health Library .. Preventing Cardiovascular Diseases .. Primary risk factors for chronic dis
Health Care Home / Health Information / Library / Diseases Conditions / Adult Health Library /. At the top of the CDC's list of primary risk factors for all chronic diseases are: smoking, poor nutrition, and sedentary lifestyle. Sticking to a heart-healthy diet. Following an appropriate exercise program. Eliminate all tobacco products. As soon as you stop smoking, your body begins to heal itself from the devastating effects of tobacco. Adhere to a heart-healthy diet. One aspect of managing your heart attack risk factors includes eating a heart-healthy diet, including appropriate levels of the following:. The food plate can help you eat a variety of foods while encouraging the right amount of calories and fat. To find more information about the Dietary Guidelines for Americans 2010 and to determine the appropriate dietary recommendations for your age, sex, and physical activity level, visit the Online Resources page for the links to the ChooseMyPlate.gov and 2010 Dietary Guidelines sites. M...
http://healthcare.utah.edu/healthlibrary/library/diseases/adult/doc.php?type=85&id=P00708
*  Other possible heart disease risk factors | womenshealth.gov
Other possible heart disease risk factors. womenshealth.gov. A project of the U.S. Department of Health and Human Services Office on Women's Health Skip Navigation. Skip top navigation Home. A-Z Health Topics. ePublications. News. About Us. Contact Us. Text size. Print. Skip left navigation Heart Health and Stroke. Heart disease and stroke prevention. Heart disease: Know your risk. Heart disease risk factors you can control. Heart disease risk factors you can't control. Other possible heart disease risk factors. Stroke: Know your risk. Signs of a heart attack. Signs of a stroke. Government in action on heart health and stroke. Heart Health and Stroke in Spanish en español. Subscribe to Heart Health and Stroke email updates. Enter email address. Submit. . Home. Heart Health and Stroke. Heart disease: Know your risk Heart Health and Stroke. Other possible heart disease risk factors. Related information Depression fact sheet. Stress and your health fact sheet. Depression, stress, and anxiety. Not enough sleep. L...
http://womenshealth.gov/heart-health-stroke/heart-disease-risk-factors/other-heart-disease-risk-factors.html
*  Psychological risk factors in patients with myocardial infarction
... redirect myocardial infarction risk factors...
https://en.wikipedia.org/wiki/Psychological_risk_factors_in_patients_with_myocardial_infarction
*  What are risk factors for heart disease? | Healthy Heart - Home
What are risk factors for heart disease. Healthy Heart - Home. What are risk factors for heart disease. Learn what conditions and behaviors might put you at risk. The Heart Truth. Posted: 11:16 AM EST Dec 29, 2011. Updated: 11:46 AM EST Jan 13, 2010. Risk factors are conditions or habits that make a person more likely to develop a disease. They can also increase the chances that an existing disease will get worse. Important risk factors for heart disease that you can do something about are:. High blood pressure. High blood cholesterol. Being physically inactive. Having a family history of early heart disease. Age 55 or older for women. Some risk factors, such as age and family history of early heart disease, can't be changed. For women, age becomes a risk factor at 55. After menopause, women are more apt to get heart disease, in part because their body's production of estrogen drops. Women who have gone through early menopause, either naturally or because they have had a hysterectomy, are twice as likely to d...
http://wfmz.com/lifestyle/healthy-heart/What-are-risk-factors-for-heart-disease/7223982?view=print
*  Cardiovascular Disease Risk Factors Prevalence Among Bayer's Employees in São Paulo, Brazil - Full
Cardiovascular Disease Risk Factors Prevalence Among Bayer's Employees in S o Paulo, Brazil - Full Text View - ClinicalTrials.gov. Find Studies Study Record Detail. Cardiovascular Disease Risk Factors Prevalence Among Bayer's Employees in S o Paulo, Brazil This study is ongoing, but not recruiting participants. ClinicalTrials.gov Identifier: NCT02055651 First received: January 24, 2014 Last updated: July 1, 2015 Last verified: July 2015 History of Changes. Objective: Evaluate Bayer employees' cardiovascular health according to the AHA definition and the acceptance to engage in lifestyle change programs. If the employee accepts to participate, after providing a written informed consent, he will be evaluated according to the AHA cardiovascular health metrics. After medical evaluation, employees will receive a printed feedback with their cardiovascular health score and will be referred to indicated lifestyle change programs healthy weight, smoking cessation, diabetes control, high blood pressure control, dyslipi...
https://clinicaltrials.gov/ct2/show/NCT02055651?term="High Blood Pressure"&lup_s=01/29/2014&lup_d=14&show_rss=Y&sel_rss=mod14
*  Increases in heart disease risk factors may decrease brain function
... News and Press Release Distribution, Since 1995. Deliver Your News to the World. Sign In Create a Free Account. Home. News. How We Work. Compare Services. FAQ. All. WebPost. WebPost PPC. WebRelease. Targeted Media. Wire Service. Increases in heart disease risk factors may decrease brain function. WEBWIRE. Thursday, May 02, 2013 NewMediaWire via Webwire Study Highlights: Increases in heart disease risk factors may decrease brain function. The association between the two was noted in young and middle-age adults as well as the elderly. Smoking and diabetes were especially linked with reduced brain function. EMBARGOED UNTIL 3 p.m. CT/4 p.m. ET, Thursday, May 2, 2013 DALLAS, May 2, 2013 — Brain function in adults as young as 35 may decline as their heart disease risk factors increase, according to new research in the American Heart Association journal Stroke. “Young adults may think the consequences of smoking or being overweight are years down the road, but they aren’t,” said Hanneke Joosten, M.D., lead auth...
http://webwire.com/ViewPressRel.asp?aId=174087
*  Heart disease risk factors - Heart - Body & Health
... Body Health Home. What is heart disease. Causes of heart disease. Symptoms of heart disease. Heart attack: Know the symptoms. Heart disease risk factors. Heart disease risk factors There are several risk factors that increase the risk of developing heart disease or the risk that heart disease will worsen. Some risk factors are things you can change: they are called modifiable risk factors. Things you can change include: Smoking : Smoking, including exposure to second-hand smoke, plays a role in the buildup of plaque in the arteries, reduces the oxygen in the blood, increases blood pressure, and increases the risk of heart disease. Physical inactivity : Low levels of physical activity are associated with a higher risk of heart disease. High blood pressure : High blood pressure - over 140/90 mm Hg for most people or over 130/80 mm Hg for those with diabetes - is associated with an increased risk for heart disease. High cholesterol : If you do not have cholesterol levels at target especially bad cholesterol...
http://bodyandhealth.canada.com/channel_section_details.asp?text_id=5400&channel_id=2104&relation_id=85907
*  Saturated Fat and Cardiometabolic Risk Factors, Coronary Heart Disease, Stroke, and Diabetes: a Fres
... h Look at the Evidence - Springer. Saturated Fat and Cardiometabolic Risk Factors, Coronary Heart Disease, Stroke, and Diabetes: a Fresh Look at the Evidence. Keywords Cardiovascular disease Diabetes mellitus Diet Nutrition Saturated fatty acids Fatty acids. CrossRef. PubMed. Am J Clin Nutr 77 5 :1146–1155. PubMed. Eur J Clin Nutr 63 Suppl 2 :S22–S33. CrossRef. PubMed. Micha R, Mozaffarian D 2009 Trans fatty acids: effects on metabolic syndrome, heart disease and diabetes. CrossRef. PubMed. CrossRef. PubMed. CrossRef. PubMed. Diabetes Care 27 3 :813–823. CrossRef. PubMed. CrossRef. PubMed. CrossRef. PubMed. Rasmussen BM et al 2006 Effects of dietary saturated, monounsaturated, and n-3 fatty acids on blood pressure in healthy subjects. Christiansen E et al 1997 Intake of a diet high in trans monounsaturated fatty acids or saturated fatty acids: effects on postprandial insulinemia and glycemia in obese patients with NIDDM. Salmeron J et al 2001 Dietary fat intake and risk of type 2 diabetes in women. Hardin...
http://link.springer.com/article/10.1007/s11745-010-3393-4
*  What are risk factors for heart disease? | Healthy Heart - Home
What are risk factors for heart disease. Healthy Heart - Home. View full site. Family. Weird News. Sports. SoFlo TASTE. Technology. Traffic. Travel. Submit a Tip. Email Sign-Up. Healthy Heart. What are risk factors for heart disease. Risk factors are conditions or habits that make a person more likely to develop a disease. Important risk factors for heart disease that you can do something about are:. High blood cholesterol. Having a family history of early heart disease. Age 55 or older for women. Some risk factors, such as age and family history of early heart disease, can't be changed. For women, age becomes a risk factor at 55. After menopause, women are more apt to get heart disease, in part because their body's production of estrogen drops. Women who have gone through early menopause, either naturally or because they have had a hysterectomy, are twice as likely to develop heart disease as women of the same age who have not yet gone through menopause. Another reason for the increasing risk is that middle ...
http://m.local10.com/healthy-heart/What-are-risk-factors-for-heart-disease/7223982
*  .. What are the Risk Factors for Heart Disease and Stroke in People with Diabetes?
Emilia.Cure. What are the Risk Factors for Heart Disease and Stroke in People with Diabetes. stumble. 31. 23. 12. 10. Get New Treatments Alerts:. Sign Up. The risk factors for heart disease and stroke for diabetic people include smoking, hypertension etc. According to the scientific studies, the risk of getting heart disease and stroke is as high as twice for those with diabetes than those without non-diabetics. Statistically, the ratio has been recorded as 2 persons for getting affected with these two ailments in every 3 diabetic patients. So, you can see that the risk is really high. On top of this, there are several other risk factors which aggravate the situation and result into critical consequences. These risk factors can be categorized as modifiable risk factors and non-modifiable risk factors. The modifiable risk factors are the ones, which you can control to enjoy a better health condition, whereas the non-modifiable risk factors are normally out of your control. The non-modifiable risk factors will ...
http://trialx.com/curetalk/2011/01/what-are-the-risk-factors-for-heart-disease-and-stroke-in-people-with-diabetes/
*  What are the risk factors for thymus cancer?
What are the risk factors for thymus cancer. Asian Pacific Languages. How can we help you. Learn About Cancer. Stay Healthy. Find Support & Treatment. Find Local ACS. Learn About Cancer. Thymus Cancer. What are the risk factors for thymus cancer. Share this Page Close. Push escape to close share window. Share. Save Saved this Article Close Push escape to close saved articles window. My Saved Articles. My ACS. Causes, Risk Factors, and Prevention TOPICS Document Topics What are the risk factors for thymus cancer. Do we know what causes thymus cancer. Can thymus cancer be prevented. What are the risk factors for thymus cancer. Do we know what causes thymus cancer. Can thymus cancer be prevented. Previous Topic What are the key statistics about thymus cancers. Next Topic Do we know what causes thymus cancer. What are the risk factors for thymus cancer. A risk factor is anything that affects your chance of getting a disease such as cancer. Different cancers have different risk factors. For example, exposing the s...
http://cancer.org/cancer/thymuscancer/detailedguide/thymus-cancer-risk-factors
*  Heart Disease Risk Factors News, Photos and Videos - Livebetteramerica.com
Heart Disease Risk Factors News, Photos and Videos - Livebetteramerica.com. FITNESS. FOOD. RECIPES. RELATIONSHIPS. VIDEO. Heart Disease Risk Factors. 6 Good Reasons To Lose Weight That Most People Never Consider. Posted 02.20.2013. Read More: Preventing Diabetes, Dieting Tips, Weight Loss Success, Preventing Obesity, When to Go on a Diet, Dieting Success, Weight Loss Success Stories, Heart Disease Risk Factors, Diet Inspiration, Video, Dieting, Losing Weight After 50, Obesity Cancer Risks, Diabetes Risks, Weight Loss, Heart Disease, Diabetes, Cancer, Causes of Diabesity, Reasons to Lose Weight, Diabetes Prevention, Losing Weight, Weight Loss Inspiration, Cancer Prevention, Heart Disease Risks, Obesity, Breast Cancer Risks, Diabesity, Preventing Heart Disease, Livebetteramerica-Fitness, Cancer Risks, Diabetes Risk Factors, News. Oh, it feels so good to lose weight. Read Whole Story. Why I Still Smoke. Posted 03.25.2013. Read More: Quitting Smoking Genetics, Cigarette Health Effects, Smoking, Relapse, Heart...
http://livebetteramerica.aol.com/tag/heart-disease-risk-factors/1
*  Impact of traditional cardiovascular disease risk factors on long-term cardiovascular outcome in adu
... lt survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Oncolink - Cancer Resources. Toggle navigation. Cancer Types. Cancer Types. Bone Cancers. Brain Tumors. Breast Cancer. Carcinoid & Neuroendocrine Tumors. Endocrine System Cancers. Gastrointestinal Cancers. Gynecologic Cancers. Head and Neck Cancers. Leukemia. Lung Cancers. Lymphomas. Metastatic Cancer. Multiple Myeloma. OncoLink Vet. Pediatric Cancers. Penile Cancer. Pheochromocytoma. Prostate Cancer. Sarcomas. Skin Cancers. Testicular Cancer. Thyroid Cancer. Urinary Tract Cancers. Patients. Cancer Treatment. Biologic Therapy. Bone Marrow Transplants. Chemotherapy. Clinical Trials. Complementary and Alternative Medicine. Gene Therapy. Getting Treatment. Start Here. Hormone Therapy. Hospital Helpers. Interventional Radiology. Procedures & Diagnostic Tests. Proton Therapy. Radiation. Surgery. Targeted Therapies. Vaccine Therapies. Risk and Prevention. Diet, Alcohol and Cancer. Environmental Factors UV Exposure, Radon, Radia...
http://oncolink.org/conferences/article.cfm?c=3&s=67&ss=346&id=2138
*  What are risk factors for heart disease? | Healthy Heart - Home
What are risk factors for heart disease. Healthy Heart - Home. Back To Mobile Site. Back To Mobile Site. Back To Mobile Site. Sign Up for Email Newsletters. RSS. More Local News. Seen on Local 10. Call Christina. Family. Local. › Healthy Heart. What are risk factors for heart disease. Risk factors are conditions or habits that make a person more likely to develop a disease. Important risk factors for heart disease that you can do something about are:. Some risk factors, such as age and family history of early heart disease, can't be changed. After menopause, women are more apt to get heart disease, in part because their body's production of estrogen drops. Women who have gone through early menopause, either naturally or because they have had a hysterectomy, are twice as likely to develop heart disease as women of the same age who have not yet gone through menopause. Another reason for the increasing risk is that middle age is a time when women tend to develop risk factors for heart disease. Family history of ...
http://local10.com/thats-life/healthy-heart/What-are-risk-factors-for-heart-disease/7223982
*  worried about high risk exposure
... ABOUT HIV/AIDS. What is HIV/AIDS. POZ Community Forums. HIV Prevention and Testing. worried about high risk exposure. HIV Prevention and Testing Am I Infected. Stats Total Posts: 675714 Total Topics: 52424 Online Today: 166 Online Ever: 585 January 07, 2014, 02:31:47 PM. Welcome to the "Am I Infected?" POZ forum. Anyone who needs to post more than three messages in the "Am I Infected?" forum -- including past, present and future POZ Forums members -- will need to subscribe, with secure payments made via PayPal. NOTE: HIV testing questions will still need to be posted in the "Am I Infected?" forum; attempts to post HIV symptoms or testing questions in any other forums will be considered violations of our rules of membership and subject to time-outs and permanent bans. so with that and me having zero symptoms i am aware symptoms or lack there of don t mean much what is the likely i got hiv from the exposure 2 years ago. Re: worried about high risk exposure Reply #1 on: July 04, 2013, 05:41:31 PM. Here s wh...
http://forums.poz.com/index.php?topic=49332.0
*  REASONS FOR INDIA’S GROWING CARDIOVASCULAR DISEASE EPIDEMIC PINPOINTED IN LARGEST-EVER RISK FACTOR
... STUDY | World Heart Federation. Press contacts REASONS FOR INDIA’S GROWING CARDIOVASCULAR DISEASE EPIDEMIC PINPOINTED IN LARGEST-EVER RISK FACTOR STUDY 19.04.2012 22:55 REASONS FOR INDIA’S GROWING CARDIOVASCULAR DISEASE EPIDEMIC PINPOINTED IN LARGEST-EVER RISK FACTOR STUDY. Dubai 20 April 2012 : The Indian Heart Watch IHW study has revealed the truth behind the prevalence, awareness, treatment and control of key risk factors that are driving the country’s growing cardiovascular disease CVD epidemic, in a first-of-a-kind presentation of data at the World Congress of Cardiology today. Seventy-nine per cent of men and 83 per cent of women were found to be physically inactive, while 51 per cent of men and 48 per cent of women were found to have high fat diets. Some 60 per cent of men and 57 per cent of women were found to have a low intake of fruit and vegetables, while 12 per cent of men and 0.5 per cent of women smoke. Overweight and obesity was reported in 41 per cent of men and 45 per cent of women....
http://world-heart-federation.org/press/releases/detail/article/reasons-for-indias-growing-cardiovascular-disease-epidemic-pinpointed-in-largest-ever-risk-factor/
*  Moffitt Cancer Center: Risk Factors
... Cancers We Treat. Find a Doctor. Clinical Trials Research. Patient Family. Cancers. Lung Cancer. Risk Factors. Risk Factors. Clinical Trials. Radiation Therapy. Lung Cancer Screening and Surveillance Program. Insurance Financial Information. Lung Cancer Risk Factors Through dedicated research, scientists have identified several risk factors for lung cancer. While some of these factors, like a patent’s genetics, can’t be changed, others can be diminished through lifestyle adjustments. Smoking is the number one risk factor for lung cancer. Cigarettes contain a number of carcinogens, and smoking introduces those toxins into the lungs. Inhaling another person’s smoke secondhand smoke exposure is also a known risk factor. While a person’s lung cancer risk goes up with the number of cigarettes they smoke per day and the number of years they have smoked, their risk can go down if they are able to stop smoking. Other lung cancer risk factors include: Exposure to radon, air pollution or other environmental hazard...
https://moffitt.org/cancers/lung-cancer/risk-factors/
*  .. Breast Cancer: Who Is at Risk?
← Join Our 2012 Denton Heart Walk Team. How Diabetes Affects Heart Health →. Breast Cancer: Who Is at Risk. October 8, 2012. Posted by. laicos. Some women are at higher risk for developing breast cancer than others. Anyone can get cancer, but some people have risk factors that may increase their chances. Certain risk factors, such as gender, are out of your control, and they do not necessarily mean you will get the disease. Even so, it is important to understand if you are at risk. According to the American Cancer Society, breast cancer is the second leading cause of cancer death in women. Some of the women had several risk factors but it’s still hard to know just how much they contributed. Risk Factors that are Out of Your Control. Breast cancer risk factors that women cannot change include:. Gender. Women are more likely to develop breast cancer than men. Age. The risk of developing breast cancer increases with age. Race / ethnicity. Family history of breast cancer. Age of first period and onset of menopaus...
http://blog.dentonregional.com/2012/10/08/breast-cancer-who-is-at-risk/
*  Phys.org - risk factors(... continued page 15)
Phys.org - risk factors ... Home risk factors. News tagged with risk factors. heart disease · patients · women · heart attack · cardiovascular disease. Patients at risk for complications after coronary artery fistula closure. Mar 23, 2010 in Diseases, Conditions, Syndromes. Infertile men have an increased risk of developing high grade prostate cancer, which is more likely to grow and spread quickly. Mar 22, 2010 in Cancer. Mar 16, 2010 in Diseases, Conditions, Syndromes. Mar 15, 2010 in Diseases, Conditions, Syndromes. Mar 03, 2010 in Diseases, Conditions, Syndromes. Individuals who were identified as being at increased risk of cardiovascular or cerebrovascular events based on screening for low ankle brachial index, a type of pressure measurement used in the diagnosis of peripheral artery ... Mar 01, 2010 in Diseases, Conditions, Syndromes. Nearly 40 different inherited risk factors which predispose to the disease have now been identified. Blacks more likely to have undiagnosed key stroke risk factor, have hi...
http://phys.org/tags/risk factors/page15.html
*  Go Red in February — Part 2: Heart disease risk factors - Lifestyle - The Lake News Online - Camd
Go Red in February Part 2: Heart disease risk factors - Lifestyle - The Lake News Online - Camdenton, MO. Go Red in February Part 2: Heart disease risk factors There are some risk factors for heart disease you can't control, such as age, gender and genetics. Having a family history of heart disease is another factor that increases risk. By Jennifer Bethurem. The Lake News Online. By Jennifer Bethurem. 4, 2013 at 1:44 PM Updated Feb 4, 2013 at 1:53 PM. By Jennifer Bethurem. 4, 2013 at 1:44 PM Updated Feb 4, 2013 at 1:53 PM Lake area. Go Red in February Part 7: Know your family history. Go Red in February Part 5: Controlling blood pressure... Lake Regional forum will address heart attacks, risk factors. There are some risk factors for heart disease you can't control, such as age, gender and genetics. Having a family history of heart disease is another factor that increases risk. Using tobacco increases your risk of heart disease, and the likelihood that you would not survive a heart attack. Stay active, eat hea...
http://lakenewsonline.com/article/20130204/LIFESTYLE/130209619/0/ENTERTAINMENTLIFE
*  Go Red in February — Part 2: Heart disease risk factors - Lifestyle - The Lake News Online - Camd
Go Red in February Part 2: Heart disease risk factors - Lifestyle - The Lake News Online - Camdenton, MO. newsletter. Go Red in February Part 2: Heart disease risk factors There are some risk factors for heart disease you can't control, such as age, gender and genetics. Having a family history of heart disease is another factor that increases risk. By Jennifer Bethurem. The Lake News Online. By Jennifer Bethurem. 4, 2013 at 1:44 PM Updated Feb 4, 2013 at 1:53 PM. By Jennifer Bethurem. 4, 2013 at 1:44 PM Updated Feb 4, 2013 at 1:53 PM Lake area. Go Red in February Part 7: Know your family history. Go Red in February Part 5: Controlling blood pressure... Lake Regional forum will address heart attacks, risk factors. There are some risk factors for heart disease you can't control, such as age, gender and genetics. Having a family history of heart disease is another factor that increases risk. Using tobacco increases your risk of heart disease, and the likelihood that you would not survive a heart attack. Stay act...
http://lakenewsonline.com/article/20130204/LIFESTYLE/130209619/0/Events
*  socioeconomic risk factors: Topics by WorldWideScience.org
Socioeconomic disparities in risk factors for cardiovascular disease. Conclusions Among Korean adults, men and women in lower socioeconomic position, as denoted by education, income, and somewhat less by occupation, experience significantly higher levels of morbidity and lower self-reported health status, even after controlling for standard behavioral risk factors. Science.gov United States Goulden, R; Ibrahim, T; Wolfson, C 2015-06-01 High socioeconomic status SES is generally associated with better health outcomes, but some research has linked it with an increased risk of multiple sclerosis MS. 2015-01-01 Background Socioeconomic inequalities in mortality can be explained by different groups of risk factors. Results Contextual variables associated with CVD risk factors included: remoteness of village with higher blood pressure and fasting blood sugar, high proportion of Yi minority with drinking, high literacy rate with a lower rate of smoking and a lower mean waist-hip ratio, and high average income with l...
http://worldwidescience.org/topicpages/s/socioeconomic risk factors.html
*  NewYork-Presbyterian/Queens - Heart Disease Prevention - Smoking and Cardiovascular Disease
... Heart Center Heart Disease Prevention - Smoking and Cardiovascular Disease According to the American Heart Association AHA, diseases caused by smoking kill more than 440,000 people in the United States each year; of that number, more than 135,000 deaths are cardiovascular related. Smokers not only have increased risk for lung disease, including lung cancer and emphysema, but also have increased risk for heart disease, stroke, and oral cancer. In posing health risks on the body's cardiovascular system, smoking: Causes immediate and long-term increases in blood pressure Causes immediate and long-term increases in heart rate Reduces cardiac output and coronary blood flow Reduces the amount of oxygen that reaches the body's tissues Changes the properties of blood vessels and blood cells allowing cholesterol and other fatty substances to build up Contributes to higher blood pressure and increased risk for blood clot formation Damages blood vessels Doubles the risk for ischemic stroke reduced blood flow to the...
http://nyhq.org/diw/content.asp?PageID=P06598&More=EVC&language=Korean
*  Study: 2 in 5 adults at risk for diabetes | WNOR FM99
Study: 2 in 5 adults at risk for diabetes. WNOR FM99. Listen Live. Search. Facebook. Twitter. Instagram. YouTube. RSS. Email. SMS. Tunein. Menu Home Media Photos. Stream FM99. Listen Live. Babe of the Day. Rumble Rumble on Demand. Stupid News. Videos. The Reach Around. Shelley s Puppies. On Air Rumble in the Morning. Shelley s Lunch Box. Eric Afternoons. Nikki Sixx. News Military. Music. Sports. Weird. Viral Videos. National. Entertainment. Events All Events. Helping Hand. Contests See All Contests. Football Challenge. Military Hero. Contest Rules. Connect Contact Us. Facebook. YouTube. Twitter. Text Club. FM99 Emails. Signup. Preferences. About Advertise with us. Contact Us. Jobs at FM99. Christmas Wish. Helping Hand. Home. News. Story. News Study: 2 in 5 adults at risk for diabetes. in National. DIABETES: Heidi Elbarky draws blood from a finger of her son, Omar, 8, to test his sugar level using OneTouch Ping that transfers the sugar level to Omar's insulin pump. More than 29 million people in the United Sta...
http://fm99.com/news/030030-study-2-in-5-adults-at-risk-for-diabetes/

Matrix model: == Mathematics and physics ==Ki-67 (protein): Antigen KI-67 also known as Ki-67 or MKI67 is a protein that in humans is encoded by the MKI67 gene (antigen identified by monoclonal antibody Ki-67).QRISK: QRISK2 (the most recent version of QRISK) is a prediction algorithm for cardiovascular disease (CVD) that uses traditional risk factors (age, systolic blood pressure, smoking status and ratio of total serum cholesterol to high-density lipoprotein cholesterol) together with body mass index, ethnicity, measures of deprivation, family history, chronic kidney disease, rheumatoid arthritis, atrial fibrillation, diabetes mellitus, and antihypertensive treatment.Cancer biomarkers: A cancer biomarker refers to a substance or process that is indicative of the presence of cancer in the body. A biomarker may be a molecule secreted by a tumor or a specific response of the body to the presence of cancer.Breast cancer classification: Breast cancer classification divides breast cancer into categories according to different schemes, each based on different criteria and serving a different purpose. The major categories are the histopathological type, the grade of the tumor, the stage of the tumor, and the expression of proteins and genes.Progesterone receptor: The progesterone receptor (PR, also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3), is a protein found inside cells. It is activated by the steroid hormone progesterone.Evolution in Variable EnvironmentTemporal analysis of products: Temporal Analysis of Products (TAP), (TAP-2), (TAP-3) is an experimental technique for studyingBiomarkers of aging: Biomarkers of aging are biomarkers that better predict functional capacity at a later age than chronological age. Stated another way, biomarkers of aging would give the true "biological age", which may be different from the chronological age.Four Seasons Baltimore and Residences: Four Seasons Hotel Baltimore is currently a 22 story highrise hotel complex building which opened on November 14, 2011. The building's construction began back in 2007 and went through several changes.Hormone receptor positive breast tumor: A hormone-receptor-positive tumor is a tumor which consists of cells that express receptors for certain hormones. The term most commonly refers to estrogen receptor positive tumors (i.ABCD rating: ABCD rating, also called the Jewett staging system or the Whitmore-Jewett staging system, is a staging system for prostate cancer that uses the letters A, B, C, and D.Gene signature: A gene signature is a group of genes in a cell whose combined expression patternItadani H, Mizuarai S, Kotani H. Can systems biology understand pathway activation?Age adjustment: In epidemiology and demography, age adjustment, also called age standardization, is a technique used to allow populations to be compared when the age profiles of the populations are quite different.List of Parliamentary constituencies in Kent: The ceremonial county of Kent,Regression dilution: Regression dilution, also known as regression attenuation, is the biasing of the regression slope towards zero (or the underestimation of its absolute value), caused by errors in the independent variable.Global Risks Report: The Global Risks Report is an annual study published by the World Economic Forum ahead of the Forum’s Annual Meeting in Davos, Switzerland. Based on the work of the Global Risk Network, the report describes changes occurring in the global risks landscape from year to year and identifies the global risks that could play a critical role in the upcoming year.Prenatal nutrition: Nutrition and weight management before and during :pregnancy has a profound effect on the development of infants. This is a rather critical time for healthy fetal development as infants rely heavily on maternal stores and nutrient for optimal growth and health outcome later in life.China Biologic Products, Inc.Biological therapy for inflammatory bowel diseaseUnited States Army Biological Warfare Laboratories: The U.S.Coles PhillipsClonal Selection Algorithm: In artificial immune systems, Clonal selection algorithms are a class of algorithms inspired by the clonal selection theory of acquired immunity that explains how B and T lymphocytes improve their response to antigens over time called affinity maturation. These algorithms focus on the Darwinian attributes of the theory where selection is inspired by the affinity of antigen-antibody interactions, reproduction is inspired by cell division, and variation is inspired by somatic hypermutation.PSI Protein Classifier: PSI Protein Classifier is a program generalizing the results of both successive and independent iterations of the PSI-BLAST program. PSI Protein Classifier determines belonging of the found by PSI-BLAST proteins to the known families.Protein primary structure: The primary structure of a peptide or protein is the linear sequence of its amino acid structural units, and partly comprises its overall biomolecular structure. By convention, the primary structure of a protein is reported starting from the amino-terminal (N) end to the carboxyl-terminal (C) end.Biopesticide: Biopesticides, a contraction of 'biological pesticides', include several types of pest management intervention: through predatory, parasitic, or chemical relationships. The term has been associated historically with biological control - and by implication - the manipulation of living organisms.Ethyl groupMac OS X Server 1.0Interval boundary element method: Interval boundary element method is classical boundary element method with the interval parameters.
Cellular microarray: A cellular microarray is a laboratory tool that allows for the multiplex interrogation of living cells on the surface of a solid support. The support, sometimes called a "chip", is spotted with varying materials, such as antibodies, proteins, or lipids, which can interact with the cells, leading to their capture on specific spots.Lattice protein: Lattice proteins are highly simplified computer models of proteins which are used to investigate protein folding.List of systems biology conferences: Systems biology is a biological study field that focuses on the systematic study of complex interactions in biological systems, thus using a new perspective (integration instead of reduction) to study them. Particularly from year 2000 onwards, the term is used widely in the biosciences.Reaction coordinateSymmetry element: A symmetry element is a point of reference about which symmetry operations can take place. In particular, symmetry elements can be centers of inversion, axes of rotation and mirror planes.Proximity ligation assay: Proximity ligation assay (in situ PLA) is a technology that extends the capabilities of traditional immunoassays to include direct detection of proteins, protein interactions and modifications with high specificity and sensitivity. Protein targets can be readily detected and localized with single molecule resolution and objectively quantified in unmodified cells and tissues.Electronic oscillator: An electronic oscillator is an electronic circuit that produces a periodic, oscillating electronic signal, often a sine wave or a square wave. Oscillators convert direct current (DC) from a power supply to an alternating current signal.Biological network: A biological network is any network that applies to biological systems. A network is any system with sub-units that are linked into a whole, such as species units linked into a whole food web.Nencki Institute of Experimental Biology: The Nencki Institute of Experimental Biology is a Polish scientific research organization and a part of Polish Academy of Sciences headquartered in Warsaw, Poland. Founded in 1918, it is a leading institution in the country in the field of neurobiology, molecular biology and biochemistry.Silent mutation: Silent mutations are mutations in DNA that do not significantly alter the phenotype of the organism in which they occur. Silent mutations can occur in non-coding regions (outside of genes or within introns), or they may occur within exons.Extracellular: In cell biology, molecular biology and related fields, the word extracellular (or sometimes extracellular space) means "outside the cell". This space is usually taken to be outside the plasma membranes, and occupied by fluid.High-performance liquid chromatography: High-performance liquid chromatography (HPLC; formerly referred to as high-pressure liquid chromatography), is a technique in analytical chemistry used to separate, identify, and quantify each component in a mixture. It relies on pumps to pass a pressurized liquid solvent containing the sample mixture through a column filled with a solid adsorbent material.Burst kinetics: Burst kinetics is a form of enzyme kinetics that refers to an initial high velocity of enzymatic turnover when adding enzyme to substrate. This initial period of high velocity product formation is referred to as the "Burst Phase".Atomic mass: right |thumb|200px|Stylized [[lithium-7 atom: 3 protons, 4 neutrons, & 3 electrons (total electrons are ~1/4300th of the mass of the nucleus). It has a mass of 7.Protein–protein interactionOntario Genomics Institute: The Ontario Genomics Institute (OGI) is a not-for-profit organization that manages cutting-edge genomics research projects and platforms.The Ontario Genomics Institute OGI also helps scientists find paths to the marketplace for their discoveries and the products to which they lead, and it works through diverse outreach and educational activities to raise awareness and facilitate informed public dialogue about genomics and its social impacts.Phenotype microarray: The phenotype microarray approach is a technology for high-throughput phenotyping of cells.DNA binding site: DNA binding sites are a type of binding site found in DNA where other molecules may bind. DNA binding sites are distinct from other binding sites in that (1) they are part of a DNA sequence (e.Mature messenger RNA: Mature messenger RNA, often abbreviated as mature mRNA is a eukaryotic RNA transcript that has been spliced and processed and is ready for translation in the course of protein synthesis. Unlike the eukaryotic RNA immediately after transcription known as precursor messenger RNA, it consists exclusively of exons, with all introns removed.Mediated transportGeneralizability theory: Generalizability theory, or G Theory, is a statistical framework for conceptualizing, investigating, and designing reliable observations. It is used to determine the reliability (i.Spin–lattice relaxation in the rotating frame: Spin–lattice relaxation in the rotating frame is the mechanism by which Mxy, the transverse component of the magnetization vector, exponentially decays towards its equilibrium value of zero, under the influence of a radio frequency (RF) field in nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI). It is characterized by the spin–lattice relaxation time constant in the rotating frame, T1ρ.SEA Native Peptide LigationFERM domain: In molecular biology, the FERM domain (F for 4.1 protein, E for ezrin, R for radixin and M for moesin) is a widespread protein module involved in localising proteins to the plasma membrane.DNA condensation: DNA condensation refers to the process of compacting DNA molecules in vitro or in vivo. Mechanistic details of DNA packing are essential for its functioning in the process of gene regulation in living systems.Christian Zheng Sheng College: Christian Zheng Sheng College () is a private school in Hong Kong established by the Christian Zheng Sheng Association (ZSA). Its founder and principal is Chan Siu Cheuk (Alman Chan).Proteomics Standards Initiative: The Proteomics Standards Initiative (PSI) is a working group of Human Proteome Organization. It aims to define data standards for proteomics in order to facilitate data comparison, exchange and verification.Branching order of bacterial phyla (Gupta, 2001): There are several models of the Branching order of bacterial phyla, one of these was proposed in 2001 by Gupta based on conserved indels or protein, termed "protein signatures", an alternative approach to molecular phylogeny. Some problematic exceptions and conflicts are present to these conserved indels, however, they are in agreement with several groupings of classes and phyla.Immersive technologyCS-BLASTMBF BiosciencePlant Proteome Database: The Plant Proteome Database is a National Science Foundation-funded project to determine the biological function of each protein in plants.Sun Q, Zybailov B, Majeran W, Friso G, Olinares PD, van Wijk KJ.Database of protein conformational diversity: The Database of protein conformational diversity (PCDB) is a database of diversity of protein tertiary structures within protein domains as determined by X-ray crystallography. Proteins are inherently flexible and this database collects information on this subject for use in molecular research.Conference and Labs of the Evaluation Forum: The Conference and Labs of the Evaluation Forum (formerly Cross-Language Evaluation Forum), or CLEF, is an organization promoting research in multilingual information access (currently focusing on European languages). Its specific functions are to maintain an underlying framework for testing information retrieval systems and to create repositories of data for researchers to use in developing comparable standards.Flux (metabolism): Flux, or metabolic flux is the rate of turnover of molecules through a metabolic pathway. Flux is regulated by the enzymes involved in a pathway.DNA sequencer: A DNA sequencer is a scientific instrument used to automate the DNA sequencing process. Given a sample of DNA, a DNA sequencer is used to determine the order of the four bases: G (guanine), C (cytosine), A (adenine) and T (thymine).List of strains of Escherichia coli: Escherichia coli is a well studied bacterium that was first identified by Theodor Escherich, after whom it was later named.

(1/1056) Charybdotoxin and apamin block EDHF in rat mesenteric artery if selectively applied to the endothelium.

In rat mesenteric artery, endothelium-derived hyperpolarizing factor (EDHF) is blocked by a combination of apamin and charybdotoxin (ChTX). The site of action of these toxins has not been established. We compared the effects of ChTX and apamin applied selectively to the endothelium and to the smooth muscle. In isometrically mounted arteries, ACh (0.01-10 micrometers), in the presence of indomethacin (2.8 microM) and Nomega-nitro-L-arginine methyl ester (L-NAME) (100 microM), concentration dependently relaxed phenylephrine (PE)-stimulated tone (EC50 50 nM; n = 10). Apamin (50 nM) and ChTX (50 nM) abolished this relaxation (n = 5). In pressurized arteries, ACh (10 microM), applied intraluminally in the presence of indomethacin (2.8 microM) and L-NAME (100 microM), dilated both PE-stimulated (0.3-0.5 microM; n = 5) and myogenic tone (n = 3). Apamin (50 nM ) and ChTX (50 nM) applied intraluminally abolished ACh-induced dilatations. Bath superperfusion of apamin and ChTX did not affect ACh-induced dilatations of either PE-stimulated (n = 5) or myogenic tone (n = 3). This is the first demonstration that ChTX and apamin act selectively on the endothelium to block EDHF-mediated relaxation.  (+info)

(2/1056) Endothelium-dependent hyperpolarization in resting and depolarized mammary and coronary arteries of guinea-pigs.

1. The membrane potential responses in guinea-pig coronary and mammary arteries attributable to endothelium-derived nitric oxide (NO), prostaglandin (PG) and hyperpolarizing factor (EDHF), and to exogenous NO and the prostacyclin analogue, iloprost, were compared at rest and when depolarized with the thromboxane analogue, U46619. 2. In the coronary artery, stimulation of the endothelium with acetylcholine (ACh) evoked hyperpolarization attributable to NO and a PG with similar pD2s at rest and in the presence of U46619. However, in depolarized tissues, the pD2 of the response attributed to EDHF required a 10 fold lower concentration of ACh compared with at rest. 3. In the mammary artery, lower concentrations of ACh were required to evoke NO- and EDHF-dependent hyperpolarizations in depolarized mammary artery compared with at rest, while PG-dependent hyperpolarization did not occur until the concentration of ACh was increased some 10 fold both at rest and in U46619. 4. The smooth muscle of the coronary artery of guinea-pigs was some 4 fold more sensitive to exogenous NO and iloprost than was the mammary artery. 5. In conclusion, the membrane potential response in arteries at rest, that is, in the absence of constrictor, may be extrapolated to events in the presence of constrictor when NO and PG are under study. However, the sensitivity to ACh and the magnitude of the hyperpolarization attributed to EDHF obtained in tissues at rest may underestimate these parameters in depolarized tissues.  (+info)

(3/1056) Effects of Aspergillus fumigatus culture filtrate on antifungal activity of human phagocytes in vitro.

BACKGROUND: Aspergillus fumigatus can colonise the airways and the lungs with localised underlying conditions and occasionally invade the surrounding lung tissues even in subjects without systemic predisposing factors, presumably by escaping the local host defences. The aim of this study was to investigate the effects of A fumigatus culture filtrate (ACF) on the activities of human phagocytes--inhibition of germination of A fumigatus spores by alveolar macrophages (AMs) and hyphal damage by polymorphonuclear leucocytes (PMNs)--which are the critical host defences against A fumigatus. METHODS: Spores were incubated with AMs at a ratio of 1:1 in a medium containing different concentrations of ACF for 10 hours at 37 degrees C. Spore germination was visualised with light microscopy and the inhibition rate was calculated. The percentage of hyphal damage caused by PMNs pretreated with various concentrations of ACF was measured by a colorimetric tetrazolium metabolic assay. RESULTS: The inhibition rate of spore germination by AMs cultured with medium alone (control) was 90 (0.8)% whereas that by AMs cultured with the medium containing 10% ACF was significantly (p < 0.05) reduced to 41.7 (4.6)%. ACF suppressed the inhibition of spore germination in a dose dependent manner without altering the phagocytosing activity against the spores. The percentage of hyphal damage caused by PMNs pretreated with medium-199 (control) was 78.1 (2.3)% compared with 65.3 (2.8)% when PMNs were pretreated with 50% ACF (p < 0.05). CONCLUSIONS: A fumigatus releases biologically active substance(s) which suppress the inhibition of spore germination by AMs and also suppress PMN mediated hyphal damage, and thus may contribute to the pathogenicity of this fungus.  (+info)

(4/1056) Inhibition of the production of endothelium-derived hyperpolarizing factor by cannabinoid receptor agonists.

1. The endogenous cannabinoid, anandamide, has been reported to induce an 'endothelium-derived hyperpolarizing factor (EDHF)-like' relaxation in vitro. We therefore investigated the effects of cannabinoid CB1 receptor agonists; HU 210, delta9-tetrahydrocannabinol (delta9-THC) and anandamide, and a CB1 antagonist/inverse agonist, SR 141716A, on nitric oxide (NO) and EDHF-mediated relaxation in precontracted rings of porcine coronary, rabbit carotid and mesenteric arteries. 2. In rings of mesenteric artery HU 210 and delta9-THC induced endothelium- and cyclo-oxygenase-independent relaxations which were sensitive to SR 141716A. Anandamide (0.03-30 microM) induced a slowly developing, endothelium-independent relaxation which was abolished by diclofenac and was therefore mediated by cyclo-oxygenase product(s). None of the CB1 agonists tested affected the tone of precontracted rings of rabbit carotid or porcine coronary artery. 3. In endothelium-intact segments, HU 210, delta9-THC and anandamide did not affect NO-mediated responses but under conditions of continuous NO synthase/cyclo-oxygenase blockade, significantly inhibited acetylcholine and bradykinin-induced relaxations which are attributed to the production of EDHF. The effects of HU 210 and delta9-THC were not observed when experiments were performed in the presence of SR 141716A suggesting the involvement of the CB1 receptor. 4. In a patch clamp bioassay of EDHF production, HU 210 decreased the EDHF-mediated hyperpolarization of detector smooth muscle cells when applied to the donor segment but was without effect on the membrane potential of detector cells. The inhibition of EDHF production was unrelated to alterations in Ca2+ -signalling or cytochrome P450 activity. 5. These results suggest that the activation of endothelial CB1 receptors appears to be negatively coupled to the production of EDHF.  (+info)

(5/1056) Proinflammatory mediators chronically downregulate the formation of the endothelium-derived hyperpolarizing factor in arteries via a nitric oxide/cyclic GMP-dependent mechanism.

BACKGROUND: Endothelium-dependent dilator responses mediated by NO and endothelium-derived hyperpolarizing factor (EDHF) are altered in arteriosclerosis and sepsis. The possibility that proinflammatory mediators that stimulate the expression of inducible NO synthase (NOS II) affect the generation of EDHF was examined in isolated arteries. METHODS AND RESULTS: Under combined blockade of NOS and cyclooxygenase, EDHF-mediated relaxation elicited by several agonists was significantly attenuated in rabbit carotid and porcine coronary arteries exposed to cytokines and lipopolysaccharide. The blunted relaxation was coincident with NOS II expression and was prevented by inhibition of NOS II as well as of global protein synthesis. The NO donor CAS 1609 and 8-bromo-cGMP mimicked the proinflammatory mediator effect. In contrast, long-term blockade of endothelial NO generation increased the relaxation in carotid but not in coronary arteries. Proinflammatory mediators reduced the synthesis of EDHF assessed as hyperpolarization of vascular smooth muscle cells elicited by the effluent from bradykinin-stimulated coronary arteries. Proinflammatory mediators induced NOS II expression in cultured endothelial cells and decreased the expression of cytochrome P450 enzymes, which are the most probable candidates for the synthesis of EDHF. CONCLUSIONS: Proinflammatory mediators inhibit the formation of EDHF in isolated arteries. This impairment is coincident with NOS II expression in the arterial wall and seems to be mediated through the induced generation of NO, which downregulates the putative EDHF-forming enzyme. Thus, a decreased formation of EDHF may contribute to the endothelial dysfunction in arteriosclerosis and sepsis.  (+info)

(6/1056) A cytosolic factor is required for mitochondrial cytochrome c efflux during apoptosis.

Treatment of HL-60 cells with staurosporine (STS) induced mitochondrial cytochrome c efflux into the cytosol, which was followed by caspase-3 activation and apoptosis. Consistent with these observations, in vitro experiments demonstrated that, except for cytochrome c, the cytosol of HL-60 cells contained sufficient amounts of all factors required for caspase-3 activation. In contrast, treatment of HCW-2 cells (an apoptotic-resistant HL-60 subclone) with STS failed to induce significant amounts of mitochondrial cytochrome c efflux, caspase-3 activation, and apoptosis. In vitro assays strongly suggested that a lack of cytochrome c in the cytosol was the primary limiting factor for caspase-3 activation in HCW-2 cells. To explore the mechanism which regulates mitochondrial cytochrome c efflux, we developed an in vitro assay which showed that cytosolic extracts from STS-treated, but not untreated, HL-60 cells contained an activity, which we designated 'CIF' (cytochrome c-efflux inducing factor), which rapidly induced cytochrome c efflux from HL-60 mitochondria. In contrast, there was no detectable CIF activity in STS-treated HCW-2 cells although the mitochondria from HCW-2 cells were responsive to the CIF activity from STS-treated HL-60 cells. These experiments have identified a novel activity, CIF, which is required for cytochrome c efflux and they indicate that the absence of CIF is the biochemical explanation for the impaired ability of HCW-2 cells to activate caspase-3 and undergo apoptosis.  (+info)

(7/1056) Involvement of CB1 cannabinoid receptors in the EDHF-dependent vasorelaxation in rabbits.

1. It was recently suggested that an endogenous cannabinoid could represent an endothelium-derived hyperpolarizing factor (EDHF). The aim of the present study was to clarify whether CB1 cannabinoid receptors are involved in the nitric oxide (NO)- and prostanoid-independent vasodilation produced by acetylcholine in rabbits. 2. Pithed rabbits received indomethacin. Noradrenaline was infused to raise blood pressure, and vasodilation was elicited by bolus injections of acetylcholine. The NO-synthase inhibitor Nomega-nitro-L-arginine methylester inhibited the acetylcholine-evoked vasodilation by about 40%. The remaining vasodilation was unaffected by the CB1 cannabinoid receptor antagonist SR141716A, but was inhibited by the potassium channel blocker tetraethylammonium. In addition, the mixed CB1/CB2 cannabinoid receptor agonist WIN55212-2 did not elicit vasodilation. 3. No CB1 cannabinoid receptors were involved in the prostanoid- and NO-independent vasodilation produced by acetylcholine. An exogenous cannabinoid also did not cause vasodilation. Therefore, it is unlikely that an endogenous cannabinoid serves as an EDHF acting at smooth muscle CB1 cannabinoid receptors in the rabbit.  (+info)

(8/1056) Relationship between NaF- and thapsigargin-induced endothelium-dependent hyperpolarization in rat mesenteric artery.

1. In isolated rat mesenteric artery with endothelium, NaF caused slowly developing hyperpolarization. The hyperpolarizing effect was unchanged in the presence of N(G)-nitro-L-arginine (L-NOARG) and indomethacin, but was markedly reduced by high K+. In Ca2+ -free medium or in the presence of Ni2+, NaF failed to produce hyperpolarization. 2. NaF-induced hyperpolarization was substantially unaffected by deferoxamine, an Al3+ chelator, okadaic acid and calyculin A, phosphatase inhibitors, and preincubation with pertussis toxin, suggesting that neither the action of fluoroaluminates as a G protein activator nor inhibition of phosphatase activity contributes to the hyperpolarizing effect. 3. The selective inhibitors of the Ca2+ -pump ATPase of endoplasmic reticulum, thapsigargin and cyclopiazonic acid, elicited hyperpolarization, whose properties were very similar to those of NaF. When intracellular Ca2+ stores had been depleted with these inhibitors, NaF no longer generated hyperpolarization. 4. In Ca2+ -free medium, NaF (or thapsigargin) caused a transient increase in the cytosolic Ca2+ concentration ([Ca2+]i) in cultured porcine aortic endothelial cells, and subsequent application of thapsigargin (or NaF) failed to increase [Ca2+]i. 5. In arterial rings precontracted with phenylephrine, NaF produced endothelium-dependent relaxation followed by sustained contraction even in the presence of L-NOARG and indomethacin. The relaxant response was abolished by high K+ or cyclopiazonic acid. 6. These results indicate that NaF causes endothelium-dependent hyperpolarization, thereby leading to smooth muscle relaxation of rat mesenteric artery. This action appears to be mediated by the promotion of Ca2+ influx into endothelial cells that can be triggered by the emptying of intracellular Ca2+ stores, as proposed for those of thapsigargin and cyclopiazonic acid.  (+info)


What are the biological factors of Dissociative Identity Disorder?


What are the biological factors of Dissociative Identity Disorder? Identify the predisposing and precipitating factors
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do your own homework


Schizophrenia is generally seen as an outgrowth of both psychosocial stressors and biological factors.?


Schizophrenia is generally seen as an outgrowth of both psychosocial stressors and biological factors.  

1.  What is the evidence that both are involved?

2.  How is this reflected in the therapy provided to schizophrenics?
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1. I worked in mental health since 1987 and I know of numerous instances where someone who had schizophrenia didn't show symptoms until after a certain traumatic event in their lives. It is a typical part of treatment to ask about family history and many people with mental illness have relatives with mental illness. I have also noticed that a lot of people with serious mental illness had chaotic childhoods with history of abuse and proverty. In addition, it is fairly common for people in the military to develop signs of mental illness after combat experiences. 
2. Psychiatrists are interested in family history. If one family member with mental illness responded well to a certain treatment, it could be taken as a clue to what might work for another person from the same family. If the patient is being seen by a counselor, they are likely to discuss how the patient felt about their upbringing and certain events in their lives.


What causes some people to be taller or shorter than others?


In other words, what are some biological factors that cause the certain stature of certain people?
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Leg size


How common is it to die of shock itself?


I know shock can cause decreased blood pressure, hyperventilation, irregular body temperature and a number of other biological factors. I know shock is dangerous and needs to be treated by keeping the person warm etc. Just how often do people die not of the experience or injury itself but of health problems caused by shock?
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Hi Cloudy

Good question. If you're wonder if people die like rabbits from fear well yes and no but shock by itself can does kill often. In fact that is how a lot of us go when we are aged by way of infection, usually and our bodies just can't take the stress and we basic go into shock before the infection really kills us also in the very young. 

Basically shock is our body mechanisms of were we have depleted our body energy reserves and we go into what is known as the fight or flight mechanism and is now spinning out of control. Our bodies is doing some very amazing chemistry and if it works we live if doesn't well the animals of plains got us before we started doing things with the body. There is also a nasty stage that we go threw in certain conditions were we go threw shock and seem to be okay. Then all at once we start bleed out of part of our body. As far as I know we still don't why this happens on very rare occasions but it does. I never seen it nor heard of anyone seeing it in my many years in the Emergency and Health field.

Oh rabbit thing is really relate to fact that more often they faint and get eaten than died from fear but they can have heart attacks a little easier than we can if they are over breed. Who knows why they faint maybe it's so they fall down hole it their to stupid to climb down, who knows but someone is sure to get a million or two study that one. Why don't you try for it?

Time for Bed.
hope this helps
Matt E.


What causes people to look older or younger then their age?


(Sorry! This might not be in the right category)

I know lifestyle is a factor. 
Like whether or not you do drugs.
Whether or not you take care of your body (exercise, taking showers, lotion (haha))
And other things...

But what are the biological factors that deal with this? Like, what kinds of genes cause this?

BQ: What causes premature graying besides stress?
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It's all in the genes. If you have good genes then you can drink and take drugs, smoke or live the high life and still look young, albeit you may age inside and still die youngish. Genes dictate everything, whether you go bald early (look at the crown princes William and Harry, who are already looking like their father and their grandfather in this respect), when you go grey, whether you develop arthritis, wrinkles, etc etc. 
Scientists are finding out more and more about genes and our DNA make-up, such that in a few years time we'll be able to repair the genes that tell the body to wear out, allowing us to live even longer healthier lives. Not sure this would be a good thing though...
BQ. Premature greying is not caused by stress, but by the actions of enzymes on the hair follicles which provide the colouring. These are also dictated by genes, so those people that go white "overnight" will usually find so did their mother, and their grandmother, not because of their stressful job. Don't forget, some people inherit genes that their mother would rather not tell them about, so sometimes "stress" is blamed, when perhaps one should check whether the postman is also prematurely white!


What are some things a father can do that a mother can't?


BESIDES the obvious biological factors, like giving birth, what are some things fathers need to do that mothers can't?
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They can serve as a role model of how a man should treat his wife and children.

all the best.


WHY does it hurt when men get hit in the testicles?


I understand that it does hurt, but curiosity makes me ask Why. What makes the testicles so sensitive that hits cause so much pain? Why can a low blow reduce a man to tears? What biological factors make the scrotum so susceptible to pain?
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imagine two nuts getting crushed. that alone shall give you an inkling of the pain we endure.


what is a genetic predisposition to serotonin imbalance?


(cause: weight loss, over- exercising /vomiting)  

this question has to do with the biological factors that cause eating disorders/anorexia.
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I found a paper on this Nadia which outlines a whole lot of information (see below).
http://serendip.brynmawr.edu/bb/neuro/neuro98/202s98-paper3/Hirst3.html

Hope this helps