Safety of probiotics that contain lactobacilli or bifidobacteria. (1/20)
Lactobacilli and bifidobacteria are extremely rare causes of infection in humans, as are probiotics based on these organisms. This lack of pathogenicity extends across all age groups and to immunocompromised individuals. Strains used for new probiotics should be chosen from the commensal flora of humans and should not carry intrinsic resistance to antibiotics that would prevent treatment of a rare probiotic infection. Vigilance regarding the detection of possible rare cases of infection due to probiotics should be maintained, and isolates should be sent to reference centers for molecular characterization and confirmation. (+info)Risk factors of development of gut-derived bacterial translocation in thermally injured rats. (2/20)
AIM: Studies have demonstrated that gut-derived bacterial translocation (BT) might play a role in the occurrence of sepsis and multiple organ dysfunction syndrome (MODS). Yet, no convincing overall analysis of risk factors for BT has been reported. The purpose of this study was to evaluate the related factors for the development of BT in burned rats. METHODS: Wistar rats were subjected to 30% third-degree burns. Then samples were taken on postburn d 1, 3, and 5. Incidence of BT and counts of mucosal bifidobacteria, fungi and E. coli, mucus sIgA, degree of injury to ileal mucosa, and plasma interleukin-6 were observed. Univariate analysis and multivariate logistic regression analysis were performed. RESULTS: The overall BT rate was 53.9% (69 in 128). The result of univariate analysis showed that the levels of plasma endotoxin and interleukin-6, the counts of mucosal fungi and E. coli, and the scores of ileum lesion were markedly increased in animals with BT compared with those without (P=0.000-0.005), while the levels of mucus sIgA and the counts of mucosal bifidobacteria were significantly reduced in animals with translocation compared with those without (P=0.000). There was a significant positive correlation between mucus sIgA and the counts of mucosal bifidobacteria (r=0.74, P=0.001). Moreover, there were strong negative correlations between scores of ileum-lesion and counts of bifidobacteria (r=-0.67, P=0.001). Multivariate logistic regression revealed that ileum lesion score (odds ratio [OR] 45.52, 95% confidence interval [CI] 5.25-394.80), and counts of mucosal bifidobacteria (OR 0.039, 95% CI 0.0032-0.48) were independent predictors of BT secondary to severe burns. CONCLUSION: Ileal lesion score and counts of mucosal bifidobacteria can be chosen as independent prognosis factors of the development of BT. Specific interventions targeting these high-risk factors might be implemented to attenuate BT, including strategies for repair of damaged intestinal mucosae and restoration of the balance of gastrointestinal flora. (+info)Bifidobacterial species differentially affect expression of cell surface markers and cytokines of dendritic cells harvested from cord blood. (3/20)
The gut microbiota may be important in the postnatal development of the immune system and hence may influence the prevalence of atopic diseases. Bifidobacteria are the most numerous bacteria in the guts of infants, and the presence or absence of certain species could be important in determining the geographic incidence of atopic diseases. We compared the fecal populations of bifidobacteria from children aged 25 to 35 days in Ghana (which has a low prevalence of atopy), New Zealand, and the United Kingdom (high-prevalence countries). Natal origin influenced the detection of bifidobacterial species in that fecal samples from Ghana almost all contained Bifidobacterium infantis whereas those of the other children did not. Choosing species on the basis of our bacteriological results, we tested bifidobacterial preparations for their effects on cell surface markers and cytokine production by dendritic cells harvested from cord blood. Species-specific effects on the expression of the dendritic-cell activation marker CD83 and the production of interleukin-10 (IL-10) were observed. Whereas CD83 expression was increased and IL-10 production was induced by Bifidobacterium bifidum, Bifidobacterium longum, and Bifidobacterium pseudocatenulatum, B. infantis failed to produce these effects. We concluded that B. infantis does not trigger the activation of dendritic cells to the degree necessary to initiate an immune response but that B. bifidum, B. longum, and B. pseudocatenulatum induce a Th2-driven immune response. A hypothesis is presented to link our observations to the prevalence of atopic diseases in different countries. (+info)Antimicrobial susceptibility of bifidobacteria. (4/20)
OBJECTIVES: The aim of our study was to analyse the antibiotic susceptibility of various strains of Bifidobacterium spp. to a wide range of antimicrobial agents. METHODS: Fifty strains belonging to eight species of bifidobacteria, isolated from humans, animals or probiotic products, were tested for susceptibility to 30 antibiotics by disc diffusion on Brucella agar supplemented with 5% laked sheep blood and vitamin K1 (1 mg/L). MICs of nine anti-anaerobe agents, including three new molecules (telithromycin, linezolid and gatifloxacin), were determined using the reference agar-dilution method. RESULTS: All strains of bifidobacteria, whatever the species, were sensitive to penicillins: penicillin G, amoxicillin (MIC(50) 0.06 mg/L), piperacillin, ticarcillin, imipenem and usually anti-Gram-positive antibiotics (macrolides, clindamycin, pristinamycin, vancomycin and teicoplanin). Susceptibility to cefalothin and cefotetan was variable. Most isolates (70%) were resistant to fusidic acid. As expected, high resistance rates were observed for aminoglycosides. Metronidazole, an agent known for its anti-anaerobe activity, was ineffective against 38% of the strains. The newly commercialized molecules, telithromycin, linezolid and gatifloxacin, were active with MIC(50)S of 1 mg/L. The only variation in susceptibility observed among the different species concerned Bifidobacterium breve, which appeared to be generally more resistant. Potentially acquired resistance was only observed against tetracycline and minocycline, in 14% of the strains. CONCLUSIONS: With regard to a general concern about the safety of probiotics, such as potential transferability of resistance determinants, bifidobacteria, with their low natural and acquired resistance to 30 antibiotics, appear risk-free. (+info)Tetracycline resistance mediated by tet(W), tet(M), and tet(O) genes of Bifidobacterium isolates from humans. (5/20)
MICs of tetracyclines were determined for 86 human Bifidobacterium isolates and three environmental strains. The tet(O) gene was found to be absent in these isolates. tet(W) and tet(M) were found in 26 and 7%, respectively, of the Bifidobacterium isolates, and one isolate contained both genes. Chromosomal DNA hybridization showed that there was one chromosomal copy of tet(W) and/or tet(M). (+info)Effect of a fermented milk containing Bifidobacterium animalis DN-173 010 on the health-related quality of life and symptoms in irritable bowel syndrome in adults in primary care: a multicentre, randomized, double-blind, controlled trial. (6/20)
BACKGROUND: Health-related quality of life (HRQoL) has been rarely evaluated as a primary endpoint in the assessment of the effect of probiotics on the irritable bowel syndrome (IBS). AIM: To study the effects of fermented milk containing Bifidobacterium animalis DN-173 010 and yoghurt strains on the IBS in a multicentre, double-blind, controlled trial. METHODS: A total of 274 primary care adults with constipation-predominant IBS (Rome II) were randomized to consume for 6 weeks either the test fermented milk or a heat-treated yoghurt (control). HRQoL and digestive symptoms were assessed after 3 and 6 weeks on an intention-to-treat population of 267 subjects. RESULTS: The HRQoL discomfort score, the primary endpoint, improved (P < 0.001) in both groups at weeks 3 and 6. The responder rate for the HRQoL discomfort score was higher (65.2 vs. 47.7%, P < 0.005), as was the decrease in bloating score [0.56 +/- (s.d.)1.01 vs. 0.31 +/- 0.87, P = 0.03], at week 3 in the test vs. the control group. In those subjects with <3 stools/week, stool frequency increased (P < 0.001) over 6 weeks in the test vs. control group. CONCLUSIONS: This study suggests a beneficial effect of a probiotic food on discomfort HRQoL score and bloating in constipation-predominant IBS, and on stool frequency in subjects with <3 stools/week. (+info)Classification of a moderately oxygen-tolerant isolate from baby faeces as Bifidobacterium thermophilum. (7/20)
BACKGROUND: Bifidobacteria are found at varying prevalence in human microbiota and seem to play an important role in the human gastrointestinal tract (GIT). Bifidobacteria are highly adapted to the human GIT which is reflected in the genome sequence of a Bifidobacterim longum isolate. The competitiveness against other bacteria is not fully understood yet but may be related to the production of antimicrobial compounds such as bacteriocins. In a previous study, 34 Bifidobacterium isolates have been isolated from baby faeces among which six showed proteinaceous antilisterial activity against Listeria monocytogenes. In this study, one of these isolates, RBL67, was further identified and characterized. RESULTS: Bifidobacterium isolate RBL67 was classified and characterized using a polyphasic approach. RBL67 was classified as Bifidobacterium thermophilum based on phenotypic and DNA-DNA hybridization characteristics, although 16S rDNA analyses and partial groEL sequences showed higher homology with B. thermacidophilum subsp. porcinum and B. thermacidophilum subsp. thermacidophilum, respectively. RBL67 was moderately oxygen-tolerant and was able to grow at pH 4 and at a temperature of 47 degrees C. CONCLUSION: In order to assign RBL67 to a species, a polyphasic approach was used. This resulted in the classification of RBL67 as a Bifidobacterium thermophilum strain. To our knowledge, this is the first report about B. thermophilum isolated from baby faeces since the B. thermophilum strains were related to ruminants and swine faeces before. B. thermophilum was previously only isolated from animal sources and was therefore suggested to be used as differential species between animal and human contamination. Our findings may disapprove this suggestion and further studies are now conducted to determine whether B. thermophilum is distributed broader in human faeces. Furthermore, the postulated differentiation between human and animal strains by growth above 45 degrees C is no longer valid since B. thermophilum is able to grow at 47 degrees C. In our study, 16S rDNA and partial groEL sequence analysis were not able to clearly assign RBL67 to a species and were contradictory. Our study suggests that partial groEL sequences may not be reliable as a single tool for species differentiation. (+info)Bifidobacterium tsurumiense sp. nov., from hamster dental plaque. (8/20)
(+info)Bifidobacteriales are a group of Gram-positive, non-spore forming bacteria that are commonly found in the human gut microbiota. They are often considered to be beneficial or probiotic organisms due to their ability to produce short-chain fatty acids and other compounds that may have health benefits.
Bifidobacteriales infections are relatively rare, but they can occur in individuals with weakened immune systems or underlying medical conditions. These infections can cause a variety of symptoms depending on the site of infection, including fever, chills, abdominal pain, diarrhea, and sepsis.
Bifidobacteriales infections are typically treated with antibiotics that are effective against Gram-positive bacteria, such as vancomycin or linezolid. However, the treatment of these infections can be complicated by the fact that many Bifidobacteriales species are resistant to multiple antibiotics.
It is important to note that while Bifidobacteriales are generally considered to be beneficial organisms, they can cause infections in certain individuals. Therefore, it is important to consult with a healthcare provider if you suspect that you may have a Bifidobacteriales infection.
Gardnerella vaginalis
List of MeSH codes (C01)
Bifidobacterium thermacidophilum
Bifidobacterium dentium
Bifidobacterium breve
Bifidus factor
Bifidobacterium adolescentis
Bifidobacterium bifidum
Bifidobacterium animalis
Bifidobacterium longum
Gardnerella vaginalis - Wikipedia
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The cervical microbiota in reproductive-age South African women with and without human papillomavirus infection - BugSigDB
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GARDNERELLA2
- A variety of diagnosis techniques are currently available for identifying Gardnerella Vaginalis such as the OSOM BV Blue assay, FemExam cards and nucleic acid amplification tests (NAATs), resulting in the determination of an ongoing BV infection. (wikipedia.org)
- This includes infections in the genera BIFIDOBACTERIUM and GARDNERELLA, in the family Bifidobacteriaceae. (lookformedical.com)
Bacteria9
- Infezioni Batteriche 18 domande Infections by bacteria, general or unspecified. (lookformedical.com)
- Infezioni Batteriche Dell'Occhio 5 domande Infections in the inner or external eye caused by microorganisms belonging to several families of bacteria. (lookformedical.com)
- Infezioni Da Batteri Gram-Negativi 1 quesito Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method. (lookformedical.com)
- Infezioni Da Batteri Gram-Positivi 2 domande Infections caused by bacteria that retain the crystal violet stain (positive) when treated by the gram-staining method. (lookformedical.com)
- Infezioni Da Actinomycetales 0 domande Infections with bacteria of the order ACTINOMYCETALES. (lookformedical.com)
- Actinomicosi 0 domande Infections with bacteria of the genus ACTINOMYCES. (lookformedical.com)
- Infezioni Da Nocardia 0 domande Infections with bacteria of the genus NOCARDIA. (lookformedical.com)
- Infezioni Da Staphylococcus 1 quesito Infections with bacteria of the genus STAPHYLOCOCCUS. (lookformedical.com)
- Infezioni Da Streptococcus 1 quesito Infections with bacteria of the genus STREPTOCOCCUS. (lookformedical.com)
Urinary2
- Fournier gangrene is usually secondary to perirectal or periurethral infections associated with local trauma, operative procedures, or urinary tract disease. (lookformedical.com)
- The bacterium has also been associated with bacteremia, urinary track infections, and neonatal meningitis. (up.ac.za)
Inflammation1
- Polmonite Batterica 1 quesito Inflammation of the lung parenchyma that is caused by bacterial infections. (lookformedical.com)
Symptoms1
- Although G. vaginalis is a major species present in bacterial vaginosis, it can also be isolated from women without any signs or symptoms of infection. (wikipedia.org)
Bifidobacteriaceae2
- This includes infections in the genera BIFIDOBACTERIUM and GARDNERELLA , in the family Bifidobacteriaceae. (nih.gov)
- A rod-shaped, gram-positive, non-acid-fast, non-spore-forming, non-motile bacterium that is a genus of the family Bifidobacteriaceae, order Bifidobacteriales, class ACTINOBACTERIA . (bvsalud.org)
Bacterial Infections2
- Infezioni Batteriche Del Sistema Nervoso Centrale 4 domande Bacterial infections of the brain, spinal cord, and meninges, including infections involving the perimeningeal spaces. (lookformedical.com)
- Polmonite Batterica 1 quesito Inflammation of the lung parenchyma that is caused by bacterial infections. (lookformedical.com)
Complications1
- It is estimated in 2018 that ~292 million individuals are chronically infected with hepatitis B virus (HBV) worldwide, [ 1 ] with nearly 887,000 annual deaths due to complications from chronic hepatitis B (CHB) infection like decompensated cirrhosis and hepatocellular carcinoma. (medscape.com)
20191
- Notably, the incidence of nosocomial carbapenem-resistant gram-negative bacilli infections decreased in 2019 (P = 0.046) and 2020 (P = 0.041) compared with that in the respective previous year. (bvsalud.org)
Genus5
- Listeriosis 0 domande Infections with bacteria of the genus LISTERIA. (lookformedical.com)
- Infezioni Da Staphylococcus 1 quesito Infections with bacteria of the genus STAPHYLOCOCCUS. (lookformedical.com)
- Polmonite Staphylococcus Aureus 0 domande Pneumonia caused by infections with bacteria of the genus STAPHYLOCOCCUS, usually with STAPHYLOCOCCUS AUREUS. (lookformedical.com)
- Infezioni Cutanee Stafilococciche 0 domande Infections to the skin caused by bacteria of the genus STAPHYLOCOCCUS. (lookformedical.com)
- Infezioni Da Streptococcus 1 quesito Infections with bacteria of the genus STREPTOCOCCUS. (lookformedical.com)
Threat to human health2
- Infections with S. enterica , which is a threat to human health, can alter the genomic, taxonomic, and functional traits of the gut microbiota. (biomedcentral.com)
- Introduction: The increasing prevalence of carbapenem-resistant gram-negative bacilli infection has emerged as a substantial threat to human health. (bvsalud.org)
Humans2
- Lactobacilli and bifidobacteria are extremely rare causes of infection in humans, as are probiotics based on these organisms. (nih.gov)
- Strains used for new probiotics should be chosen from the commensal flora of humans and should not carry intrinsic resistance to antibiotics that would prevent treatment of a rare probiotic infection. (nih.gov)
Order3
- Infections with BACTERIA of the order Bifidobacteriales. (nih.gov)
- Infezioni Da Actinomycetales 0 domande Infections with bacteria of the order ACTINOMYCETALES. (lookformedical.com)
- Lichtheimia ramosa (L. ramosa) is an opportunistic fungal pathogen of the order Mucorales that may result in a rare but serious mucormycosis infection. (bvsalud.org)
Human1
- Mouse models and human studies revealed that HBV infection is associated with significant alteration of gut microbiota, which differ depending on the stage of CHB disease progression. (medscape.com)
Chronic1
- Foruncolosi 0 domande A persistent skin infection marked by the presence of furuncles, often chronic and recurrent. (lookformedical.com)
Detection3
- Vigilance regarding the detection of possible rare cases of infection due to probiotics should be maintained, and isolates should be sent to reference centers for molecular characterization and confirmation. (nih.gov)
- Due to a lack of awareness of the infection, the standard care of amphotericin B treatment was delayed and not administered until the identification of L. ramosa by metagenomic next-generation sequencing (mNGS)-based pan-pathogen detection of the patient's peripheral blood sample. (bvsalud.org)
- Our study not only highlighted the clinical value of comprehensive mNGS in rapid pathogen detection but also raised awareness of recognizing lethal fungal infection early in immunocompromised hosts including pediatric cancer patients. (bvsalud.org)
Significant2
- Salmonella infections are a significant global public health threat and contribute to morbidity and mortality worldwide [ 3 ]. (biomedcentral.com)
- Results: The increase in the single room isolation (type A) and the resettlement of the same area placement (type B) resulted in a significant decrease in the nosocomial infection rate from 2.57% (50/1945) in 2017 to 0.87% (15/1720) in 2021 (P (bvsalud.org)
Early1
- Similarly, Campylobacter infections occur most often in early childhood into young adulthood, while Salmonella infections have higher rates in infants and people over 65 [ 2 ]. (biomedcentral.com)
Cases1
- We also reviewed the literature on L. ramosa infection cases reported worldwide between 2010 and 2022, with an analysis of clinical manifestation, prognosis, and epidemiological data. (bvsalud.org)
Highly1
- The infection is highly lethal, especially in immunocompromised hosts, and the incidence has been on the rise. (bvsalud.org)
Common1
- Impetigine 0 domande A common superficial bacterial infection caused by STAPHYLOCOCCUS AUREUS or group A beta-hemolytic streptococci. (lookformedical.com)
Negative2
- Infezioni Da Batteri Gram-Negativi 1 quesito Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method. (lookformedical.com)
- Conclusion: The integration of various placements for patients with carbapenem-resistant gram-negative bacilli infection with active screening has been demonstrated as an effective preventive strategy in the management of carbapenem-resistant gram-negative bacilli infection. (bvsalud.org)