Ilex paraguariensis: A plant species of the family AQUIFOLIACEAE. An infusion of the leaves is commonly drunk in South America for stimulating effect in much the same manner as coffee is in other cultures.Ilex: A plant genus of the family AQUIFOLIACEAE. The common name of 'holly' usually refers to this genus but may sometimes refer to similar looking plants of the MAHONIA or QUERCUS genus.Chlorogenic Acid: A naturally occurring phenolic acid which is a carcinogenic inhibitor. It has also been shown to prevent paraquat-induced oxidative stress in rats. (From J Chromatogr A 1996;741(2):223-31; Biosci Biotechnol Biochem 1996;60(5):765-68).Plant Extracts: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.Glipizide: An oral hypoglycemic agent which is rapidly absorbed and completely metabolized.