Chromosome Walking
A technique with which an unknown region of a chromosome can be explored. It is generally used to isolate a locus of interest for which no probe is available but that is known to be linked to a gene which has been identified and cloned. A fragment containing a known gene is selected and used as a probe to identify other overlapping fragments which contain the same gene. The nucleotide sequences of these fragments can then be characterized. This process continues for the length of the chromosome.
Walking
Chromosome Mapping
Ganoderma
A genus of fungi in the family Ganodermataceae, order POLYPORALES, containing a dimitic hyphal system. It causes a white rot, and is a wood decomposer. Ganoderma lucidum (REISHI) is used in traditional Chinese medicine (MEDICINE, CHINESE TRADITIONAL).
Chromosomes
Cosmids
Physical Chromosome Mapping
Mapping of the linear order of genes on a chromosome with units indicating their distances by using methods other than genetic recombination. These methods include nucleotide sequencing, overlapping deletions in polytene chromosomes, and electron micrography of heteroduplex DNA. (From King & Stansfield, A Dictionary of Genetics, 5th ed)
Cloning, Molecular
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Genetic Markers
Base Sequence
Chromosome Banding
Staining of bands, or chromosome segments, allowing the precise identification of individual chromosomes or parts of chromosomes. Applications include the determination of chromosome rearrangements in malformation syndromes and cancer, the chemistry of chromosome segments, chromosome changes during evolution, and, in conjunction with cell hybridization studies, chromosome mapping.
X Chromosome
Restriction Mapping
Chromosome Aberrations
Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.
Sex Chromosomes
The homologous chromosomes that are dissimilar in the heterogametic sex. There are the X CHROMOSOME, the Y CHROMOSOME, and the W, Z chromosomes (in animals in which the female is the heterogametic sex (the silkworm moth Bombyx mori, for example)). In such cases the W chromosome is the female-determining and the male is ZZ. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
Chromosomes, Human, Pair 1
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
Nucleic Acid Hybridization
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
Chromosomes, Human
Very long DNA molecules and associated proteins, HISTONES, and non-histone chromosomal proteins (CHROMOSOMAL PROTEINS, NON-HISTONE). Normally 46 chromosomes, including two sex chromosomes are found in the nucleus of human cells. They carry the hereditary information of the individual.
Chromosomes, Bacterial
Chromosome Segregation
The orderly segregation of CHROMOSOMES during MEIOSIS or MITOSIS.
Chromosomes, Human, Pair 7
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
Chromosomes, Human, Pair 11
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
Chromosomes, Human, Pair 17
A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.
Amino Acid Sequence
Chromosomes, Human, Pair 6
Chromosomes, Human, Pair 9
Chromosomes, Human, Pair 21
A specific pair of GROUP G CHROMOSOMES of the human chromosome classification.
Chromosomes, Plant
Chromosomes, Fungal
Chromosomes, Human, 6-12 and X
The medium-sized, submetacentric human chromosomes, called group C in the human chromosome classification. This group consists of chromosome pairs 6, 7, 8, 9, 10, 11, and 12 and the X chromosome.
Chromosomes, Human, Pair 2
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
Chromosomes, Human, Pair 16
A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.
Chromosomes, Human, Pair 22
A specific pair of GROUP G CHROMOSOMES of the human chromosome classification.
Chromosome Pairing
The alignment of CHROMOSOMES at homologous sequences.
Chromosomes, Mammalian
Chromosomes, Human, Pair 13
A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.
Chromosomes, Human, Pair 4
A specific pair of GROUP B CHROMOSOMES of the human chromosome classification.
Chromosomes, Human, Pair 10
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
Chromosomes, Human, Y
Chromosomes, Human, Pair 8
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
Chromosomes, Human, Pair 19
A specific pair of GROUP F CHROMOSOMES of the human chromosome classification.